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Aliases for ARRDC2 Gene

Aliases for ARRDC2 Gene

  • Arrestin Domain Containing 2 2 3 5
  • Arrestin Domain-Containing Protein 2 3
  • CLONE24945 3
  • PP2703 3

External Ids for ARRDC2 Gene

Previous GeneCards Identifiers for ARRDC2 Gene

  • GC19P017979
  • GC19P018111
  • GC19P017677
  • GC19P018123
  • GC19P018180
  • GC19P018300
  • GC19P018332
  • GC19P018706
  • GC19P019015

Summaries for ARRDC2 Gene

GeneCards Summary for ARRDC2 Gene

ARRDC2 (Arrestin Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is ARRDC3.

Additional gene information for ARRDC2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARRDC2 Gene

Genomics for ARRDC2 Gene

Regulatory Elements for ARRDC2 Gene

Enhancers for ARRDC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H018019 2 FANTOM5 Ensembl ENCODE dbSUPER 19.4 +21.5 21466 5.6 HDGF MLX ARNT ARID4B SIN3A YY1 SLC30A9 ZNF766 ZNF207 ZNF143 ARRDC2 IFI30 ENSG00000268030 GTPBP3 COMP UBA52 LRRC25 JUND FCHO1 MAP1S
GH19H018300 2.1 FANTOM5 Ensembl ENCODE dbSUPER 9.3 +303.4 303374 8.2 HDGF PKNOX1 FOXA2 ARNT SIN3A ARID4B DMAP1 ZBTB7B YY1 SLC30A9 ENSG00000268030 UPF1 KIAA1683 ENSG00000268938 NR2C2AP MEF2B JUND LSM4 COLGALT1 ENSG00000269191
GH19H018012 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +15.1 15115 6.7 PKNOX1 MLX ZFP64 ARID4B DMAP1 ZNF121 ATF7 SP5 PPARG KAT8 IFI30 ARRDC2 JAK3 COMP JUND FCHO1 IL12RB1 LRRC25 MAP1S LOC440514
GH19H018048 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.6 +48.1 48124 1.7 KLF1 MAX YBX1 RAD21 YY1 NCOR1 REST FOXA1 GABPA JUND ARRDC2 IFI30 RPS18P13 MAST3
GH19H018029 1.3 ENCODE dbSUPER 12.4 +28.6 28590 1.3 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 YY1 FOS DEK TSHZ1 REST ARRDC2 ENSG00000269191 LOC440514 LOC646666
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARRDC2 on UCSC Golden Path with GeneCards custom track

Promoters for ARRDC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107989 568 1801 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A YY1 SLC30A9 ZNF143 ZNF207

Genomic Locations for ARRDC2 Gene

Genomic Locations for ARRDC2 Gene
chr19:18,001,132-18,014,102
(GRCh38/hg38)
Size:
12,971 bases
Orientation:
Plus strand
chr19:18,111,941-18,124,911
(GRCh37/hg19)

Genomic View for ARRDC2 Gene

Genes around ARRDC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARRDC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARRDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARRDC2 Gene

Proteins for ARRDC2 Gene

  • Protein details for ARRDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBH0-ARRD2_HUMAN
    Recommended name:
    Arrestin domain-containing protein 2
    Protein Accession:
    Q8TBH0
    Secondary Accessions:
    • B2RBG9
    • O95895
    • Q6ZRV9
    • Q8WYG6

    Protein attributes for ARRDC2 Gene

    Size:
    407 amino acids
    Molecular mass:
    44379 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ARRDC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARRDC2 Gene

Post-translational modifications for ARRDC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARRDC2 Gene

No data available for DME Specific Peptides for ARRDC2 Gene

Domains & Families for ARRDC2 Gene

Gene Families for ARRDC2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARRDC2 Gene

Suggested Antigen Peptide Sequences for ARRDC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TBH0

UniProtKB/Swiss-Prot:

ARRD2_HUMAN :
  • Belongs to the arrestin family.
Family:
  • Belongs to the arrestin family.
genes like me logo Genes that share domains with ARRDC2: view

Function for ARRDC2 Gene

Phenotypes From GWAS Catalog for ARRDC2 Gene

genes like me logo Genes that share phenotypes with ARRDC2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARRDC2 Gene

Localization for ARRDC2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARRDC2 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARRDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 23236378
GO:0031410 cytoplasmic vesicle IDA 23236378
genes like me logo Genes that share ontologies with ARRDC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARRDC2 Gene

Pathways & Interactions for ARRDC2 Gene

SuperPathways for ARRDC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARRDC2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ARRDC2 Gene

Drugs & Compounds for ARRDC2 Gene

No Compound Related Data Available

Transcripts for ARRDC2 Gene

Unigene Clusters for ARRDC2 Gene

Arrestin domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARRDC2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10a · 10b
SP1: - -
SP2: - -
SP3: - -
SP4: - - - - -
SP5: - -
SP6:
SP7:
SP8:

Relevant External Links for ARRDC2 Gene

GeneLoc Exon Structure for
ARRDC2
ECgene alternative splicing isoforms for
ARRDC2

Expression for ARRDC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARRDC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARRDC2 Gene

This gene is overexpressed in Muscle - Skeletal (x6.0).

NURSA nuclear receptor signaling pathways regulating expression of ARRDC2 Gene:

ARRDC2

SOURCE GeneReport for Unigene cluster for ARRDC2 Gene:

Hs.515249

Evidence on tissue expression from TISSUES for ARRDC2 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with ARRDC2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARRDC2 Gene

Orthologs for ARRDC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARRDC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARRDC2 33 34
  • 99.26 (n)
dog
(Canis familiaris)
Mammalia ARRDC2 33 34
  • 87.22 (n)
cow
(Bos Taurus)
Mammalia ARRDC2 33 34
  • 85.67 (n)
mouse
(Mus musculus)
Mammalia Arrdc2 33 16 34
  • 79.12 (n)
oppossum
(Monodelphis domestica)
Mammalia ARRDC2 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARRDC2 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARRDC2 33 34
  • 71.55 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia arrdc2 33
  • 64.1 (n)
zebrafish
(Danio rerio)
Actinopterygii arrdc2 33 34
  • 61.82 (n)
-- 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11055 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001894 33
  • 46.53 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1105 33
  • 46.02 (n)
Vdup1 34
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea arrd-17 33
  • 40.02 (n)
arrd-16 34
  • 25 (a)
ManyToMany
arrd-12 34
  • 21 (a)
ManyToMany
arrd-6 34
  • 21 (a)
ManyToMany
Species where no ortholog for ARRDC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARRDC2 Gene

ENSEMBL:
Gene Tree for ARRDC2 (if available)
TreeFam:
Gene Tree for ARRDC2 (if available)

Paralogs for ARRDC2 Gene

Paralogs for ARRDC2 Gene

(3) SIMAP similar genes for ARRDC2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARRDC2: view

Variants for ARRDC2 Gene

Sequence variations from dbSNP and Humsavar for ARRDC2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000006638 -- 18,014,097(+) TGGAG(A/G)AAGAA utr-variant-3-prime
rs1000181924 -- 18,000,697(+) GAAAA(A/C)ACAGA upstream-variant-2KB
rs1000234080 -- 18,000,589(+) ACTCT(-/GTC)TTAAA upstream-variant-2KB
rs1000305372 -- 18,005,568(+) GCGGC(C/T)GGGCA intron-variant
rs1000376211 -- 18,014,399(+) AGAGA(C/G)TGGGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ARRDC2 Gene

Variant ID Type Subtype PubMed ID
nsv833772 CNV gain+loss 17160897
nsv470130 CNV loss 18288195
nsv2428 CNV insertion 18451855
esv3643829 CNV gain 21293372
esv3643828 CNV gain 21293372

Variation tolerance for ARRDC2 Gene

Residual Variation Intolerance Score: 57.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.03; 84.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARRDC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARRDC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARRDC2 Gene

Disorders for ARRDC2 Gene

Relevant External Links for ARRDC2

Genetic Association Database (GAD)
ARRDC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARRDC2

No disorders were found for ARRDC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARRDC2 Gene

Publications for ARRDC2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  4. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3 60
  5. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3 60

Products for ARRDC2 Gene

Sources for ARRDC2 Gene

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