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Aliases for ARRDC2 Gene

Aliases for ARRDC2 Gene

  • Arrestin Domain Containing 2 2 3
  • Arrestin Domain-Containing Protein 2 3
  • CLONE24945 3
  • PP2703 3

External Ids for ARRDC2 Gene

Previous GeneCards Identifiers for ARRDC2 Gene

  • GC19P017979
  • GC19P018111
  • GC19P017677

Summaries for ARRDC2 Gene

GeneCards Summary for ARRDC2 Gene

ARRDC2 (Arrestin Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is ARRDC3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARRDC2 Gene

Genomics for ARRDC2 Gene

Regulatory Elements for ARRDC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARRDC2 Gene

18,001,132 bp from pter
18,014,102 bp from pter
12,971 bases
Plus strand

Genomic View for ARRDC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARRDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARRDC2 Gene

Proteins for ARRDC2 Gene

  • Protein details for ARRDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arrestin domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B2RBG9
    • O95895
    • Q6ZRV9
    • Q8WYG6

    Protein attributes for ARRDC2 Gene

    407 amino acids
    Molecular mass:
    44379 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ARRDC2 Gene


neXtProt entry for ARRDC2 Gene

Proteomics data for ARRDC2 Gene at MOPED

Post-translational modifications for ARRDC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARRDC2 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ARRDC2

No data available for DME Specific Peptides for ARRDC2 Gene

Domains for ARRDC2 Gene

Protein Domains for ARRDC2 Gene

Suggested Antigen Peptide Sequences for ARRDC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the arrestin family.
  • Belongs to the arrestin family.
genes like me logo Genes that share domains with ARRDC2: view

No data available for Gene Families for ARRDC2 Gene

Function for ARRDC2 Gene

Animal Model Products

miRNA for ARRDC2 Gene

miRTarBase miRNAs that target ARRDC2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARRDC2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for ARRDC2 Gene

Localization for ARRDC2 Gene

Subcellular locations from

Jensen Localization Image for ARRDC2 Gene COMPARTMENTS Subcellular localization image for ARRDC2 gene
Compartment Confidence
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ARRDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 23236378
GO:0031410 cytoplasmic vesicle IDA 23236378
genes like me logo Genes that share ontologies with ARRDC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARRDC2 Gene

Pathways for ARRDC2 Gene

SuperPathways for ARRDC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARRDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with ARRDC2: view

No data available for Pathways by source for ARRDC2 Gene

Transcripts for ARRDC2 Gene

Unigene Clusters for ARRDC2 Gene

Arrestin domain containing 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARRDC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARRDC2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10a · 10b
SP1: - -
SP2: - -
SP3: - -
SP4: - - - - -
SP5: - -

Relevant External Links for ARRDC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARRDC2 Gene

mRNA expression in normal human tissues for ARRDC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARRDC2 Gene

This gene is overexpressed in Muscle - Skeletal (6.0).

SOURCE GeneReport for Unigene cluster for ARRDC2 Gene Hs.515249

genes like me logo Genes that share expressions with ARRDC2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for ARRDC2 Gene

Orthologs for ARRDC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARRDC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARRDC2 35
  • 85.67 (n)
  • 91.4 (a)
  • 91 (a)
(Canis familiaris)
Mammalia ARRDC2 35
  • 87.22 (n)
  • 93.12 (a)
  • 93 (a)
(Mus musculus)
Mammalia Arrdc2 35
  • 79.12 (n)
  • 80.84 (a)
Arrdc2 16
Arrdc2 36
  • 81 (a)
(Pan troglodytes)
Mammalia ARRDC2 35
  • 99.26 (n)
  • 99.26 (a)
  • 99 (a)
(Monodelphis domestica)
Mammalia ARRDC2 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia ARRDC2 36
  • 69 (a)
(Gallus gallus)
Aves ARRDC2 35
  • 71.55 (n)
  • 68.18 (a)
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arrdc2 35
  • 64.1 (n)
  • 65.51 (a)
(Danio rerio)
Actinopterygii -- 35
arrdc2 35
  • 61.82 (n)
  • 60.84 (a)
arrdc2 36
  • 60 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11055 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001894 35
  • 46.53 (n)
  • 33.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1105 35
  • 46.02 (n)
  • 32.66 (a)
Vdup1 36
  • 27 (a)
(Caenorhabditis elegans)
Secernentea arrd-17 35
  • 40.02 (n)
  • 33.33 (a)
arrd-12 36
  • 21 (a)
arrd-16 36
  • 25 (a)
arrd-6 36
  • 21 (a)
Species with no ortholog for ARRDC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARRDC2 Gene

Gene Tree for ARRDC2 (if available)
Gene Tree for ARRDC2 (if available)

Paralogs for ARRDC2 Gene

Paralogs for ARRDC2 Gene

(3) SIMAP similar genes for ARRDC2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARRDC2: view

Variants for ARRDC2 Gene

Sequence variations from dbSNP and Humsavar for ARRDC2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs371135 -- 18,014,484(+) GTGGG(G/T)ttttt downstream-variant-500B
rs1046798 -- 18,013,954(+) CATTA(A/G)AGGGG utr-variant-3-prime
rs1046803 -- 18,014,034(+) CATTT(C/T)TGATA utr-variant-3-prime
rs1046806 -- 18,009,039(+) GCACC(A/G/T)GCCCT missense, reference
rs1108004 -- 18,002,620(+) AGAAG(C/T)TTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARRDC2 Gene

Variant ID Type Subtype PubMed ID
nsv911214 CNV Loss 21882294
nsv833772 CNV Gain+Loss 17160897
nsv911227 CNV Loss 21882294
dgv3767n71 CNV Loss 21882294
nsv470130 CNV Loss 18288195
dgv3769n71 CNV Loss 21882294
nsv2428 CNV Insertion 18451855

Relevant External Links for ARRDC2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARRDC2 Gene

Disorders for ARRDC2 Gene

Relevant External Links for ARRDC2

Genetic Association Database (GAD)

No disorders were found for ARRDC2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ARRDC2 Gene

Publications for ARRDC2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  5. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3

Products for ARRDC2 Gene

Sources for ARRDC2 Gene

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