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Aliases for ARRDC2 Gene

Aliases for ARRDC2 Gene

  • Arrestin Domain Containing 2 2 3 5
  • Arrestin Domain-Containing Protein 2 3
  • CLONE24945 3
  • PP2703 3

External Ids for ARRDC2 Gene

Previous GeneCards Identifiers for ARRDC2 Gene

  • GC19P017979
  • GC19P018111
  • GC19P017677
  • GC19P018123
  • GC19P018180
  • GC19P018300
  • GC19P018332

Summaries for ARRDC2 Gene

GeneCards Summary for ARRDC2 Gene

ARRDC2 (Arrestin Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is ARRDC3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARRDC2 Gene

Genomics for ARRDC2 Gene

Regulatory Elements for ARRDC2 Gene

Enhancers for ARRDC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F018029 0.5 ENCODE 12.4 +28.6 28590 1.3 PKNOX1 ARID4B SIN3A FEZF1 ZNF121 FOS DEK TSHZ1 ZNF623 KAT8 ARRDC2 ENSG00000269191 LOC440514 LOC646666
GH19F018048 1.4 FANTOM5 Ensembl ENCODE 11.5 +48.2 48162 1.8 HDGF ATF1 YBX1 ZNF48 RAD21 YY1 ZNF335 ZNF121 SMARCA5 USF2 ARRDC2 IFI30 RPS18P13 MAST3
GH19F018300 1.6 FANTOM5 Ensembl ENCODE 9.3 +303.4 303374 8.2 CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 NFYC TBX21 ENSG00000268030 UPF1 COLGALT1 JUND LSM4 ANO8 PGPEP1 IL12RB1 ARRDC2 SSBP4
GH19F018043 1.6 FANTOM5 Ensembl ENCODE 8.4 +44.2 44160 3.2 HDGF PKNOX1 SIN3A ARID4B DMAP1 ZNF2 ZNF766 ZNF143 FOS KLF13 UPF1 ENSG00000268030 MVB12A ENSG00000268199 ENSG00000268938 ARRDC2 IFI30 JUND GC19P019191 RPS18P13
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ARRDC2 on UCSC Golden Path with GeneCards custom track

Promoters for ARRDC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000344594 668 2401 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for ARRDC2 Gene

18,001,132 bp from pter
18,014,102 bp from pter
12,971 bases
Plus strand

Genomic View for ARRDC2 Gene

Genes around ARRDC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARRDC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARRDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARRDC2 Gene

Proteins for ARRDC2 Gene

  • Protein details for ARRDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arrestin domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B2RBG9
    • O95895
    • Q6ZRV9
    • Q8WYG6

    Protein attributes for ARRDC2 Gene

    407 amino acids
    Molecular mass:
    44379 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ARRDC2 Gene


neXtProt entry for ARRDC2 Gene

Post-translational modifications for ARRDC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARRDC2 Gene

No data available for DME Specific Peptides for ARRDC2 Gene

Domains & Families for ARRDC2 Gene

Gene Families for ARRDC2 Gene

Protein Domains for ARRDC2 Gene

Suggested Antigen Peptide Sequences for ARRDC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the arrestin family.
  • Belongs to the arrestin family.
genes like me logo Genes that share domains with ARRDC2: view

Function for ARRDC2 Gene

genes like me logo Genes that share phenotypes with ARRDC2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARRDC2 Gene

Localization for ARRDC2 Gene

Subcellular locations from

Jensen Localization Image for ARRDC2 Gene COMPARTMENTS Subcellular localization image for ARRDC2 gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ARRDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 23236378
GO:0031410 cytoplasmic vesicle IDA 23236378
genes like me logo Genes that share ontologies with ARRDC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARRDC2 Gene

Pathways & Interactions for ARRDC2 Gene

SuperPathways for ARRDC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARRDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with ARRDC2: view

No data available for Pathways by source and SIGNOR curated interactions for ARRDC2 Gene

Transcripts for ARRDC2 Gene

Unigene Clusters for ARRDC2 Gene

Arrestin domain containing 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARRDC2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10a · 10b
SP1: - -
SP2: - -
SP3: - -
SP4: - - - - -
SP5: - -

Relevant External Links for ARRDC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARRDC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARRDC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARRDC2 Gene

This gene is overexpressed in Muscle - Skeletal (x6.0).

NURSA nuclear receptor signaling pathways regulating expression of ARRDC2 Gene:


SOURCE GeneReport for Unigene cluster for ARRDC2 Gene:

genes like me logo Genes that share expression patterns with ARRDC2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ARRDC2 Gene

Orthologs for ARRDC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARRDC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARRDC2 34 35
  • 99.26 (n)
(Canis familiaris)
Mammalia ARRDC2 34 35
  • 87.22 (n)
(Bos Taurus)
Mammalia ARRDC2 34 35
  • 85.67 (n)
(Mus musculus)
Mammalia Arrdc2 34 16 35
  • 79.12 (n)
(Monodelphis domestica)
Mammalia ARRDC2 35
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia ARRDC2 35
  • 69 (a)
(Gallus gallus)
Aves ARRDC2 34 35
  • 71.55 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia arrdc2 34
  • 64.1 (n)
(Danio rerio)
Actinopterygii arrdc2 34 35
  • 61.82 (n)
-- 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11055 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001894 34
  • 46.53 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1105 34
  • 46.02 (n)
Vdup1 35
  • 27 (a)
(Caenorhabditis elegans)
Secernentea arrd-17 34
  • 40.02 (n)
arrd-16 35
  • 25 (a)
arrd-12 35
  • 21 (a)
arrd-6 35
  • 21 (a)
Species where no ortholog for ARRDC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARRDC2 Gene

Gene Tree for ARRDC2 (if available)
Gene Tree for ARRDC2 (if available)

Paralogs for ARRDC2 Gene

Paralogs for ARRDC2 Gene

(3) SIMAP similar genes for ARRDC2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARRDC2: view

Variants for ARRDC2 Gene

Sequence variations from dbSNP and Humsavar for ARRDC2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10405164 -- 18,006,390(+) gaggc(C/T)gaggc intron-variant, upstream-variant-2KB
rs10405650 -- 18,014,390(+) TCTAT(C/T)CTCAG downstream-variant-500B
rs10411508 -- 17,999,765(+) TAGCC(A/G)AGGAG upstream-variant-2KB
rs10423375 -- 18,006,433(+) cagcc(C/G)ggcca intron-variant, upstream-variant-2KB
rs10423598 -- 18,006,517(+) GGCAG(A/G)CTGAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ARRDC2 Gene

Variant ID Type Subtype PubMed ID
esv3643828 CNV gain 21293372
esv3643829 CNV gain 21293372
nsv2428 CNV insertion 18451855
nsv470130 CNV loss 18288195
nsv833772 CNV gain+loss 17160897

Variation tolerance for ARRDC2 Gene

Residual Variation Intolerance Score: 57.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.03; 84.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARRDC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARRDC2 Gene

Disorders for ARRDC2 Gene

Relevant External Links for ARRDC2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARRDC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARRDC2 Gene

Publications for ARRDC2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  4. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3 64
  5. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3 64

Products for ARRDC2 Gene

Sources for ARRDC2 Gene

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