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Aliases for ARRDC1 Gene

Aliases for ARRDC1 Gene

  • Arrestin Domain Containing 1 2 3 5
  • Alpha-Arrestin 1 2

External Ids for ARRDC1 Gene

Previous GeneCards Identifiers for ARRDC1 Gene

  • GC09P135718
  • GC09P137775
  • GC09P139619
  • GC09P140500
  • GC09P109962

Summaries for ARRDC1 Gene

GeneCards Summary for ARRDC1 Gene

ARRDC1 (Arrestin Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is ARRDC3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARRDC1 Gene

Genomics for ARRDC1 Gene

Regulatory Elements for ARRDC1 Gene

Promoters for ARRDC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARRDC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARRDC1 Gene

Chromosome:
9
Start:
137,605,640 bp from pter
End:
137,615,360 bp from pter
Size:
9,721 bases
Orientation:
Plus strand

Genomic View for ARRDC1 Gene

Genes around ARRDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARRDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARRDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARRDC1 Gene

Proteins for ARRDC1 Gene

  • Protein details for ARRDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5I2-ARRD1_HUMAN
    Recommended name:
    Arrestin domain-containing protein 1
    Protein Accession:
    Q8N5I2

    Protein attributes for ARRDC1 Gene

    Size:
    433 amino acids
    Molecular mass:
    45981 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARRDC1 Gene

Proteomics data for ARRDC1 Gene at MOPED

Post-translational modifications for ARRDC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARRDC1 Gene

Antibody Products

No data available for DME Specific Peptides for ARRDC1 Gene

Domains & Families for ARRDC1 Gene

Protein Domains for ARRDC1 Gene

Suggested Antigen Peptide Sequences for ARRDC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N5I2

UniProtKB/Swiss-Prot:

ARRD1_HUMAN :
  • Belongs to the arrestin family.
Family:
  • Belongs to the arrestin family.
genes like me logo Genes that share domains with ARRDC1: view

No data available for Gene Families for ARRDC1 Gene

Function for ARRDC1 Gene

genes like me logo Genes that share phenotypes with ARRDC1: view

Animal Models for ARRDC1 Gene

MGI Knock Outs for ARRDC1:

Animal Model Products

miRNA for ARRDC1 Gene

miRTarBase miRNAs that target ARRDC1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARRDC1 Gene

Localization for ARRDC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARRDC1 Gene COMPARTMENTS Subcellular localization image for ARRDC1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ARRDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 23236378
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ARRDC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARRDC1 Gene

Pathways & Interactions for ARRDC1 Gene

SuperPathways for ARRDC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARRDC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ARRDC1 Gene

Drugs & Compounds for ARRDC1 Gene

No Compound Related Data Available

Transcripts for ARRDC1 Gene

Unigene Clusters for ARRDC1 Gene

Arrestin domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARRDC1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - -
SP8: - -
SP9:

Relevant External Links for ARRDC1 Gene

GeneLoc Exon Structure for
ARRDC1
ECgene alternative splicing isoforms for
ARRDC1

Expression for ARRDC1 Gene

mRNA expression in normal human tissues for ARRDC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARRDC1 Gene

This gene is overexpressed in Lung (25.1) and Urine (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARRDC1 Gene



SOURCE GeneReport for Unigene cluster for ARRDC1 Gene Hs.12999

genes like me logo Genes that share expression patterns with ARRDC1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ARRDC1 Gene

Orthologs for ARRDC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARRDC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARRDC1 35
  • 86.4 (n)
  • 89.15 (a)
ARRDC1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARRDC1 35
  • 86.54 (n)
  • 88.63 (a)
ARRDC1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arrdc1 35
  • 84.19 (n)
  • 85.58 (a)
Arrdc1 16
Arrdc1 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARRDC1 35
  • 97 (n)
  • 96.51 (a)
ARRDC1 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arrdc1 35
  • 83.29 (n)
  • 86.31 (a)
oppossum
(Monodelphis domestica)
Mammalia ARRDC1 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARRDC1 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARRDC1 35
  • 69.14 (n)
  • 69.14 (a)
ARRDC1 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARRDC1 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arrdc1 35
  • 67.39 (n)
  • 65.77 (a)
zebrafish
(Danio rerio)
Actinopterygii arrdc1b 35
  • 59.37 (n)
  • 58.81 (a)
sbcb786 35
arrdc1a 36
  • 41 (a)
OneToMany
arrdc1b 36
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10086 36
  • 17 (a)
OneToMany
CG1105 36
  • 20 (a)
OneToMany
CG14696 36
  • 19 (a)
OneToMany
CG18744 36
  • 17 (a)
OneToMany
CG18745 36
  • 18 (a)
OneToMany
CG18746 36
  • 18 (a)
OneToMany
CG18747 36
  • 20 (a)
OneToMany
CG18748 36
  • 19 (a)
OneToMany
CG2641 36
  • 17 (a)
OneToMany
CG2993 36
  • 19 (a)
OneToMany
CG3014 36
  • 16 (a)
OneToMany
CG4674 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea arrd-11 36
  • 16 (a)
OneToMany
arrd-13 36
  • 16 (a)
OneToMany
arrd-14 36
  • 20 (a)
OneToMany
arrd-17 36
  • 19 (a)
OneToMany
arrd-18 36
  • 17 (a)
OneToMany
arrd-19 36
  • 18 (a)
OneToMany
arrd-20 36
  • 22 (a)
OneToMany
arrd-21 36
  • 19 (a)
OneToMany
arrd-22 36
  • 17 (a)
OneToMany
arrd-24 36
  • 22 (a)
OneToMany
arrd-5 36
  • 21 (a)
OneToMany
arrd-7 36
  • 20 (a)
OneToMany
arrd-8 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToMany
-- 36
  • 24 (a)
OneToMany
Species with no ortholog for ARRDC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARRDC1 Gene

ENSEMBL:
Gene Tree for ARRDC1 (if available)
TreeFam:
Gene Tree for ARRDC1 (if available)

Paralogs for ARRDC1 Gene

Paralogs for ARRDC1 Gene

genes like me logo Genes that share paralogs with ARRDC1: view

Variants for ARRDC1 Gene

Sequence variations from dbSNP and Humsavar for ARRDC1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_048335 -
rs1475495 -- 137,613,803(-) GGTGG(A/G)GACCC intron-variant
rs821312 -- 137,612,163(-) TGGAC(A/G)ATCAG intron-variant, utr-variant-5-prime
rs821313 -- 137,611,757(-) CTCCA(C/T)ATGCA intron-variant, utr-variant-5-prime
rs2260127 -- 137,603,643(+) TTTCT(G/T)TTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ARRDC1 Gene

Variant ID Type Subtype PubMed ID
nsv894387 CNV Gain 21882294
dgv8412n71 CNV Loss 21882294
nsv831762 CNV Loss 17160897
nsv831763 CNV Loss 17160897
dgv8462n71 CNV Loss 21882294
nsv894669 CNV Loss 21882294
nsv894670 CNV Loss 21882294
dgv8463n71 CNV Loss 21882294

Variation tolerance for ARRDC1 Gene

Residual Variation Intolerance Score: 19.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.05; 60.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARRDC1 Gene

HapMap Linkage Disequilibrium report
ARRDC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARRDC1 Gene

Disorders for ARRDC1 Gene

Relevant External Links for ARRDC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARRDC1

No disorders were found for ARRDC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARRDC1 Gene

Publications for ARRDC1 Gene

  1. I9-arrestin 1 (ARRDC1) and I^-arrestins cooperate to mediate Notch degradation in mammals. (PMID: 23886940) Puca L. … Brou C. (J. Cell. Sci. 2013) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. CHIP-MYTH: a novel interactive proteomics method for the assessment of agonist-dependent interactions of the human I^a88-adrenergic receptor. (PMID: 24561123) Kittanakom S. … Stagljar I. (Biochem. Biophys. Res. Commun. 2014) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3

Products for ARRDC1 Gene

Sources for ARRDC1 Gene

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