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Aliases for ARRDC1 Gene

Aliases for ARRDC1 Gene

  • Arrestin Domain Containing 1 2 3 5
  • Alpha-Arrestin 1 2

External Ids for ARRDC1 Gene

Previous GeneCards Identifiers for ARRDC1 Gene

  • GC09P135718
  • GC09P137775
  • GC09P139619
  • GC09P140500
  • GC09P109962

Summaries for ARRDC1 Gene

GeneCards Summary for ARRDC1 Gene

ARRDC1 (Arrestin Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is ARRDC4.

Additional gene information for ARRDC1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARRDC1 Gene

Genomics for ARRDC1 Gene

Regulatory Elements for ARRDC1 Gene

Enhancers for ARRDC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H137694 1.3 Ensembl ENCODE dbSUPER 16.9 +89.7 89669 1 GTF2F1 CTCF MXI1 ESRRA SAP130 ARID4B MAX RAD21 TEAD3 E2F1 EHMT1 ARRDC1 ARRDC1-AS1 SETP5 GC09P137764
GH09H137627 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.3 +23.8 23822 3 HDAC1 FOXA2 ETV1 SIN3A MAX BMI1 RFX5 ZNF121 ZNF316 POLR2A EHMT1 ARRDC1 DPH7 ZMYND19 LOC651337 ANAPC2 NDOR1 ENSG00000274841
GH09H137632 1.4 Ensembl ENCODE dbSUPER 12.3 +27.3 27252 1 INSM2 KLF17 ZNF2 ZNF121 ZNF366 ZSCAN5C FOS EGR2 TSHZ1 ZEB2 ZMYND19 ARRDC1 DPH7 EHMT1 ENSG00000274841
GH09H137678 1.3 Ensembl ENCODE dbSUPER 12.1 +74.4 74437 3 PKNOX1 TBL1XR1 MAX FEZF1 EBF1 ZKSCAN1 GATA3 POLR2A EED PATZ1 EHMT1 ZMYND19 ARRDC1-AS1 ARRDC1 EXD3 NOXA1 SETP5 GC09P137764
GH09H137682 1.2 Ensembl ENCODE dbSUPER 11.5 +77.1 77079 0 CTCF SP2 TSHZ1 ZIC2 OSR2 ZFHX2 GLIS2 ZNF366 GLIS1 ZBTB33 PNPLA7 ARRDC1-AS1 EHMT1 ARRDC1 ZMYND19 EXD3 NOXA1 SETP5 GC09P137764
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARRDC1 on UCSC Golden Path with GeneCards custom track

Promoters for ARRDC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000243237 -40 2001 SIN3A ZNF121 GLIS2 ELK1 ZNF143 ATF7 SP3 REST ZNF592 MBD2

Genomic Location for ARRDC1 Gene

Chromosome:
9
Start:
137,605,640 bp from pter
End:
137,615,360 bp from pter
Size:
9,721 bases
Orientation:
Plus strand

Genomic View for ARRDC1 Gene

Genes around ARRDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARRDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARRDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARRDC1 Gene

Proteins for ARRDC1 Gene

  • Protein details for ARRDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5I2-ARRD1_HUMAN
    Recommended name:
    Arrestin domain-containing protein 1
    Protein Accession:
    Q8N5I2

    Protein attributes for ARRDC1 Gene

    Size:
    433 amino acids
    Molecular mass:
    45981 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARRDC1 Gene

Post-translational modifications for ARRDC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARRDC1 Gene

Domains & Families for ARRDC1 Gene

Gene Families for ARRDC1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARRDC1 Gene

Suggested Antigen Peptide Sequences for ARRDC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N5I2

UniProtKB/Swiss-Prot:

ARRD1_HUMAN :
  • Belongs to the arrestin family.
Family:
  • Belongs to the arrestin family.
genes like me logo Genes that share domains with ARRDC1: view

Function for ARRDC1 Gene

Gene Ontology (GO) - Molecular Function for ARRDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23236378
genes like me logo Genes that share ontologies with ARRDC1: view
genes like me logo Genes that share phenotypes with ARRDC1: view

Animal Models for ARRDC1 Gene

MGI Knock Outs for ARRDC1:

Animal Model Products

CRISPR Products

miRNA for ARRDC1 Gene

miRTarBase miRNAs that target ARRDC1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ARRDC1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARRDC1 Gene

Localization for ARRDC1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARRDC1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
peroxisome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARRDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 23236378
GO:0031410 cytoplasmic vesicle IDA 23236378
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ARRDC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARRDC1 Gene

Pathways & Interactions for ARRDC1 Gene

SuperPathways for ARRDC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARRDC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ARRDC1 Gene

Drugs & Compounds for ARRDC1 Gene

No Compound Related Data Available

Transcripts for ARRDC1 Gene

Unigene Clusters for ARRDC1 Gene

Arrestin domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ARRDC1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ARRDC1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - -
SP8: - -
SP9:

Relevant External Links for ARRDC1 Gene

GeneLoc Exon Structure for
ARRDC1
ECgene alternative splicing isoforms for
ARRDC1

Expression for ARRDC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARRDC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARRDC1 Gene

This gene is overexpressed in Lung (25.1) and Urine (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARRDC1 Gene



NURSA nuclear receptor signaling pathways regulating expression of ARRDC1 Gene:

ARRDC1

SOURCE GeneReport for Unigene cluster for ARRDC1 Gene:

Hs.12999

Evidence on tissue expression from TISSUES for ARRDC1 Gene

  • Blood(4.3)
  • Liver(4.2)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with ARRDC1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARRDC1 Gene

Orthologs for ARRDC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARRDC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARRDC1 33 34
  • 97 (n)
dog
(Canis familiaris)
Mammalia ARRDC1 33 34
  • 86.54 (n)
cow
(Bos Taurus)
Mammalia ARRDC1 33 34
  • 86.4 (n)
mouse
(Mus musculus)
Mammalia Arrdc1 33 16 34
  • 84.19 (n)
rat
(Rattus norvegicus)
Mammalia Arrdc1 33
  • 83.29 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ARRDC1 34
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARRDC1 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARRDC1 33 34
  • 69.14 (n)
lizard
(Anolis carolinensis)
Reptilia ARRDC1 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arrdc1 33
  • 67.39 (n)
zebrafish
(Danio rerio)
Actinopterygii arrdc1b 33 34
  • 59.37 (n)
arrdc1a 34
  • 41 (a)
OneToMany
sbcb786 33
fruit fly
(Drosophila melanogaster)
Insecta CG1105 34
  • 20 (a)
OneToMany
CG18747 34
  • 20 (a)
OneToMany
CG14696 34
  • 19 (a)
OneToMany
CG18748 34
  • 19 (a)
OneToMany
CG2993 34
  • 19 (a)
OneToMany
CG18745 34
  • 18 (a)
OneToMany
CG18746 34
  • 18 (a)
OneToMany
CG4674 34
  • 18 (a)
OneToMany
CG10086 34
  • 17 (a)
OneToMany
CG18744 34
  • 17 (a)
OneToMany
CG2641 34
  • 17 (a)
OneToMany
CG3014 34
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea arrd-8 34
  • 24 (a)
OneToMany
arrd-20 34
  • 22 (a)
OneToMany
arrd-24 34
  • 22 (a)
OneToMany
arrd-5 34
  • 21 (a)
OneToMany
arrd-14 34
  • 20 (a)
OneToMany
arrd-7 34
  • 20 (a)
OneToMany
arrd-17 34
  • 19 (a)
OneToMany
arrd-21 34
  • 19 (a)
OneToMany
arrd-19 34
  • 18 (a)
OneToMany
arrd-18 34
  • 17 (a)
OneToMany
arrd-22 34
  • 17 (a)
OneToMany
arrd-11 34
  • 16 (a)
OneToMany
arrd-13 34
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
OneToMany
-- 34
  • 24 (a)
OneToMany
Species where no ortholog for ARRDC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARRDC1 Gene

ENSEMBL:
Gene Tree for ARRDC1 (if available)
TreeFam:
Gene Tree for ARRDC1 (if available)

Paralogs for ARRDC1 Gene

Paralogs for ARRDC1 Gene

genes like me logo Genes that share paralogs with ARRDC1: view

Variants for ARRDC1 Gene

Sequence variations from dbSNP and Humsavar for ARRDC1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000134992 -- 137,615,336(+) CTCCT(A/G)TAAAT nc-transcript-variant, utr-variant-3-prime
rs1000427898 -- 137,613,166(+) TAGGC(A/G)CTGGG intron-variant
rs1000485847 -- 137,604,363(+) CCCAC(C/T)CCCAA upstream-variant-2KB
rs1000846912 -- 137,610,361(+) CTGCC(C/T)CCTTT intron-variant, upstream-variant-2KB
rs1000876389 -- 137,610,109(+) CGCCC(A/G)GCCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARRDC1 Gene

Variant ID Type Subtype PubMed ID
dgv13012n54 CNV loss 21841781
dgv4180n106 CNV deletion 24896259
nsv1076229 CNV deletion 25765185
nsv616023 CNV loss 21841781
nsv831762 CNV loss 17160897
nsv831763 CNV loss 17160897
nsv951212 CNV deletion 24416366

Variation tolerance for ARRDC1 Gene

Residual Variation Intolerance Score: 19.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.05; 60.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARRDC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARRDC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARRDC1 Gene

Disorders for ARRDC1 Gene

Relevant External Links for ARRDC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARRDC1

No disorders were found for ARRDC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARRDC1 Gene

Publications for ARRDC1 Gene

  1. Α-arrestin 1 (ARRDC1) and β-arrestins cooperate to mediate Notch degradation in mammals. (PMID: 23886940) Puca L … Brou C (Journal of cell science 2013) 2 3 60
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3 60

Products for ARRDC1 Gene

Sources for ARRDC1 Gene

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