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Aliases for ARRDC1 Gene

Aliases for ARRDC1 Gene

  • Arrestin Domain Containing 1 2 3
  • Alpha-Arrestin 1 2

External Ids for ARRDC1 Gene

Previous GeneCards Identifiers for ARRDC1 Gene

  • GC09P135718
  • GC09P137775
  • GC09P139619
  • GC09P140500
  • GC09P109962

Summaries for ARRDC1 Gene

GeneCards Summary for ARRDC1 Gene

ARRDC1 (Arrestin Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is ARRDC3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARRDC1 Gene

Genomics for ARRDC1 Gene

Regulatory Elements for ARRDC1 Gene

Genomic Location for ARRDC1 Gene

Start:
137,605,640 bp from pter
End:
137,615,360 bp from pter
Size:
9,721 bases
Orientation:
Plus strand

Genomic View for ARRDC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARRDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARRDC1 Gene

Proteins for ARRDC1 Gene

  • Protein details for ARRDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5I2-ARRD1_HUMAN
    Recommended name:
    Arrestin domain-containing protein 1
    Protein Accession:
    Q8N5I2
    Secondary Accessions:

    Protein attributes for ARRDC1 Gene

    Size:
    433 amino acids
    Molecular mass:
    45981 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARRDC1 Gene

Proteomics data for ARRDC1 Gene at MOPED

Post-translational modifications for ARRDC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARRDC1 Gene

No data available for DME Specific Peptides for ARRDC1 Gene

Domains for ARRDC1 Gene

Protein Domains for ARRDC1 Gene

Suggested Antigen Peptide Sequences for ARRDC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N5I2

UniProtKB/Swiss-Prot:

ARRD1_HUMAN :
  • Q8N5I2
Family:
  • Belongs to the arrestin family.
genes like me logo Genes that share domains with ARRDC1: view

No data available for Gene Families for ARRDC1 Gene

Function for ARRDC1 Gene

Phenotypes for ARRDC1 Gene

GenomeRNAi human phenotypes for ARRDC1:
genes like me logo Genes that share phenotypes with ARRDC1: view

miRNA for ARRDC1 Gene

miRTarBase miRNAs that target ARRDC1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARRDC1 Gene

Localization for ARRDC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARRDC1 Gene COMPARTMENTS Subcellular localization image for ARRDC1 gene
Compartment Confidence
endosome 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ARRDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 23236378
GO:0031410 cytoplasmic vesicle IDA 23236378
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ARRDC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARRDC1 Gene

Pathways for ARRDC1 Gene

SuperPathways for ARRDC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARRDC1 Gene

None

No data available for Pathways by source for ARRDC1 Gene

Transcripts for ARRDC1 Gene

Unigene Clusters for ARRDC1 Gene

Arrestin domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARRDC1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - -
SP8: - -
SP9:

Relevant External Links for ARRDC1 Gene

GeneLoc Exon Structure for
ARRDC1
ECgene alternative splicing isoforms for
ARRDC1

Expression for ARRDC1 Gene

mRNA expression in normal human tissues for ARRDC1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARRDC1 Gene

SOURCE GeneReport for Unigene cluster for ARRDC1 Gene Hs.12999

genes like me logo Genes that share expressions with ARRDC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARRDC1 Gene

Orthologs for ARRDC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARRDC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARRDC1 35
  • 97 (n)
  • 96.51 (a)
ARRDC1 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARRDC1 35
  • 86.4 (n)
  • 89.15 (a)
ARRDC1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARRDC1 35
  • 86.54 (n)
  • 88.63 (a)
ARRDC1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arrdc1 35
  • 84.19 (n)
  • 85.58 (a)
Arrdc1 16
Arrdc1 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARRDC1 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARRDC1 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arrdc1 35
  • 83.29 (n)
  • 86.31 (a)
chicken
(Gallus gallus)
Aves ARRDC1 35
  • 69.14 (n)
  • 69.14 (a)
ARRDC1 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARRDC1 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arrdc1 35
  • 67.39 (n)
  • 65.77 (a)
zebrafish
(Danio rerio)
Actinopterygii arrdc1a 36
  • 41 (a)
OneToMany
arrdc1b 35
  • 59.37 (n)
  • 58.81 (a)
arrdc1b 36
  • 55 (a)
OneToMany
sbcb786 35
fruit fly
(Drosophila melanogaster)
Insecta CG10086 36
  • 17 (a)
OneToMany
CG1105 36
  • 20 (a)
OneToMany
CG14696 36
  • 19 (a)
OneToMany
CG18744 36
  • 17 (a)
OneToMany
CG18745 36
  • 18 (a)
OneToMany
CG18746 36
  • 18 (a)
OneToMany
CG18747 36
  • 20 (a)
OneToMany
CG18748 36
  • 19 (a)
OneToMany
CG2641 36
  • 17 (a)
OneToMany
CG2993 36
  • 19 (a)
OneToMany
CG3014 36
  • 16 (a)
OneToMany
CG4674 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea arrd-11 36
  • 16 (a)
OneToMany
arrd-13 36
  • 16 (a)
OneToMany
arrd-14 36
  • 20 (a)
OneToMany
arrd-17 36
  • 19 (a)
OneToMany
arrd-18 36
  • 17 (a)
OneToMany
arrd-19 36
  • 18 (a)
OneToMany
arrd-20 36
  • 22 (a)
OneToMany
arrd-21 36
  • 19 (a)
OneToMany
arrd-22 36
  • 17 (a)
OneToMany
arrd-24 36
  • 22 (a)
OneToMany
arrd-5 36
  • 21 (a)
OneToMany
arrd-7 36
  • 20 (a)
OneToMany
arrd-8 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToMany
-- 36
  • 24 (a)
OneToMany
Species with no ortholog for ARRDC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARRDC1 Gene

ENSEMBL:
Gene Tree for ARRDC1 (if available)
TreeFam:
Gene Tree for ARRDC1 (if available)

Paralogs for ARRDC1 Gene

Paralogs for ARRDC1 Gene

genes like me logo Genes that share paralogs with ARRDC1: view

Variants for ARRDC1 Gene

Sequence variations from dbSNP and Humsavar for ARRDC1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs821312 -- 137,612,163(-) TGGAC(A/G)ATCAG intron-variant, utr-variant-5-prime
rs821313 -- 137,611,757(-) CTCCA(C/T)ATGCA intron-variant, utr-variant-5-prime
rs1475495 -- 137,613,803(-) GGTGG(A/G)GACCC intron-variant
rs2260127 -- 137,603,643(+) TTTCT(G/T)TTTTT upstream-variant-2KB
rs2282020 -- 137,612,856(-) CCGAC(A/G)GCCCA intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ARRDC1 Gene

Variant ID Type Subtype PubMed ID
nsv894387 CNV Gain 21882294
dgv8412n71 CNV Loss 21882294
nsv831762 CNV Loss 17160897
nsv831763 CNV Loss 17160897
dgv8462n71 CNV Loss 21882294
nsv894669 CNV Loss 21882294
nsv894670 CNV Loss 21882294
dgv8463n71 CNV Loss 21882294

Relevant External Links for ARRDC1 Gene

HapMap Linkage Disequilibrium report
ARRDC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARRDC1 Gene

Disorders for ARRDC1 Gene

No disorders were found for ARRDC1 Gene.

No data available for UniProtKB/Swiss-Prot for ARRDC1 Gene

Publications for ARRDC1 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. I9-arrestin 1 (ARRDC1) and I^-arrestins cooperate to mediate Notch degradation in mammals. (PMID: 23886940) Puca L. … Brou C. (J. Cell. Sci. 2013) 2 3
  4. CHIP-MYTH: a novel interactive proteomics method for the assessment of agonist-dependent interactions of the human I^a88-adrenergic receptor. (PMID: 24561123) Kittanakom S. … Stagljar I. (Biochem. Biophys. Res. Commun. 2014) 3
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4

Products for ARRDC1 Gene

Sources for ARRDC1 Gene

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