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ARRDC1 Gene

protein-coding   GIFtS: 45
GCID: GC09P140500

Arrestin Domain Containing 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Arrestin Domain Containing 11 2
Alpha-Arrestin 11 2
Arrestin Domain-Containing Protein 12

External Ids:    HGNC: 286331   Entrez Gene: 927142   Ensembl: ENSG000001970707   UniProtKB: Q8N5I23   

Export aliases for ARRDC1 gene to outside databases

Previous GC identifers: GC09P135718 GC09P137775 GC09P139619 GC09P109962


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ARRDC1 Gene:
ARRDC1 (arrestin domain containing 1) is a protein-coding gene. An important paralog of this gene is TXNIP.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARRDC1 gene promoter:
         SRF   Pbx1a   Pax-5   SRF (504 AA)   Brachyury   Arnt   Max   c-Myb   Zic3   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARRDC1 promoter sequence
   Search Chromatin IP Primers for ARRDC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARRDC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

ARRDC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARRDC1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P140500:  view genomic region     (about GC identifiers)

Start:
140,500,096 bp from pter      End:
140,509,812 bp from pter
Size:
9,717 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ARRD1_HUMAN, Q8N5I2 (See protein sequence)
Recommended Name: Arrestin domain-containing protein 1  
Size: 433 amino acids; 45981 Da

Explore the universe of human proteins at neXtProt for ARRDC1: NX_Q8N5I2

Explore proteomics data for ARRDC1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARRDC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689498.1  
    ENSEMBL proteins: 
     ENSP00000360475   ENSP00000406247   ENSP00000435996   ENSP00000406833  

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    antibodies-online proteins for ARRDC1 (4 products) 

     
    antibodies-online peptides for ARRDC1

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    antibodies-online antibodies for ARRDC1 (27 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR014756 Ig_E-set
     IPR011022 Arrestin_C-like
     IPR011021 Arrestin-like_N

    Graphical View of Domain Structure for InterPro Entry Q8N5I2

    ProtoNet protein and cluster: Q8N5I2

    UniProtKB/Swiss-Prot: ARRD1_HUMAN, Q8N5I2
    Similarity: Belongs to the arrestin family


    Find genes that share domains with ARRDC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for ARRDC1:
     Increased HPV18 LCR reporter a 

         1 MGI phenotypic allele for Arrdc1 (no phenotypes)

    Find genes that share phenotypes with ARRDC1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Arrdc1tm1(KOMP)Vlcg for ARRDC1

       genOway: Develop your customized and physiologically relevant rodent model for ARRDC1

    miRNA
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    miRTarBase miRNAs that target ARRDC1:
    hsa-mir-326 (MIRT043649)

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    8 qRT-PCR Assays for microRNAs that regulate ARRDC1:
    hsa-miR-4324 hsa-miR-544b hsa-miR-124 hsa-miR-1283 hsa-miR-506 hsa-miR-1291 hsa-miR-3622a-5p hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidARRDC1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARRDC1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA--
    GO:0030904retromer complex ----
    GO:0031410cytoplasmic vesicle IDA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with ARRDC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARRDC1
    Interactions:

        Search GeneGlobe Interaction Network for ARRDC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for ARRDC1 (Q8N5I23 ENSP000003604754) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2E1P519653, ENSP000003037094I2D: score=1 STRING: ENSP00000303709
    PAHP004393I2D: score=1 
    UBE2E3Q969T43I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    NEDD4ENSP000003455304STRING: ENSP00000345530
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007034vacuolar transport ----

    Find genes that share ontologies with ARRDC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARRDC1 (ARRD1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARRDC1 gene: 
    NM_152285.2  

    Unigene Cluster for ARRDC1:

    Arrestin domain containing 1
    Hs.12999  [show with all ESTs]
    Unigene Representative Sequence: CR627251
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371421(uc004cns.3 uc004cnp.2) ENST00000483563 ENST00000431925
    ENST00000461627 ENST00000419386 ENST00000466367 ENST00000471125 ENST00000495220
    ENST00000491911(uc004cnx.2) ENST00000497877 ENST00000468983 ENST00000475658

    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate ARRDC1:
    hsa-miR-4324 hsa-miR-544b hsa-miR-124 hsa-miR-1283 hsa-miR-506 hsa-miR-1291 hsa-miR-3622a-5p hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidARRDC1 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARRDC1
    Addgene plasmids for ARRDC1 
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    Additional mRNA sequence: 

    AJ420420.1 AK001822.1 AK308376.1 BC032346.1 CR627251.1 

    18 DOTS entries:

    DT.452572  DT.445689  DT.100029336  DT.100885520  DT.95243574  DT.95243599  DT.100885527  DT.100894879 
    DT.121145228  DT.100805702  DT.100885506  DT.121145191  DT.75146938  DT.91748085  DT.91748089  DT.97846786 
    DT.97846787  DT.121145183 

    Selected AceView cDNA sequences (see all 340):

    BQ687239 BE328689 CR603444 AW593995 BG680157 AA278861 BX406038 CR595686 
    BI834876 CR603835 CR596578 CB242823 BU170266 BI962735 AW130957 CF529559 
    BG674324 BF063255 BQ688030 BM819008 CA312242 BQ574281 BM673943 BQ012260 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARRDC1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11
    SP1:                    -     -           -     -                                                                           
    SP2:                    -     -           -     -                       -                                                   
    SP3:                    -     -                                                                                             
    SP4:                    -     -           -     -                 -                                                         
    SP5:                          -           -     -                       -                                                   


    ECgene alternative splicing isoforms for ARRDC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARRDC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCAGTGAG
    ARRDC1 Expression
    About this image

    ARRDC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARRDC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.12999
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARRDC1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arrdc11 , 5 arrestin domain containing 11, 5 84.19(n)1
    85.58(a)1
      2 (16.84 cM)5
    2157051  NM_178408.31  NP_848495.21 
     249253525 
    chicken
    (Gallus gallus)
    Aves ARRDC11 arrestin domain containing 1 69.14(n)
    69.14(a)
      427772  NM_001031475.1  NP_001026646.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARRDC16
    arrestin domain containing 1
    65(a)
    1 ↔ 1
    GL344460.1(2124-8633)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480331052   -- 74.81(n)    48033105 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb7862 sbcb786 74.64(n)   378740  CK030025.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG187476
    CG11056
    (see all 12)
    --
    20(a)
    20(a)
    (see all 12)
    1 ↔ many
    1 ↔ many
    (see all 12)
    3R(3606712-3609123)
    3R(2889908-2892854)
    worm
    (Caenorhabditis elegans)
    Secernentea arrd-86
    arrd-206
    (see all 13)
    Protein ARRD-20 (arrd-20) mRNA, complete cds
    (see all 13)
    24(a)
    22(a)
    (see all 13)
    1 ↔ many
    1 ↔ many
    (see all 13)
    II(12065085-12067568) WBGene00012467
    V(3386491-3388156) WBGene00015440


    ENSEMBL Gene Tree for ARRDC1 (if available)
    TreeFam Gene Tree for ARRDC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARRDC1 gene
    TXNIP2  ARRDC32  ARRDC22  ARRDC42  

    Find genes that share paralogs with ARRDC1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARRDC1 (see all 303)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs713878511,2
    C--140498106(+) TTTTTT/-TGAAA 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs123413441,2
    C--140498172(+) gcaagC/Ttccgc 1 -- us2k10--------
    rs1848756751,2
    --140498190(+) ATTCAC/TGCCAT 1 -- us2k10--------
    rs1175528731,2
    F--140498230(+) GACCAC/TGGCGC 1 -- us2k11Minor allele frequency- T:0.06EA 120
    rs1447116881,2
    --140498234(+) ACGGCA/GCCTGT 1 -- us2k10--------
    rs1893368331,2
    --140498245(+) CACCAC/TGCCCG 1 -- us2k10--------
    rs745681941,2
    C--140498333(+) TGACCC/TCGTGA 1 -- us2k10--------
    rs126846801,2
    H--140498397(+) cccggG/TGAAAC 1 -- us2k10--------
    rs727651801,2
    C,F--140498452(+) GCTGTC/TCACAA 1 -- us2k11Minor allele frequency- T:0.08NA 120
    rs1478787821,2
    C--140498623(+) CCTGGC/TCCGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARRDC1 (140500096 - 140509812 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ARRDC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831762CNV Loss17160897
    dgv8462n71CNV Loss21882294
    nsv894669CNV Loss21882294
    nsv831763CNV Loss17160897
    dgv8463n71CNV Loss21882294
    nsv894670CNV Loss21882294
    dgv8412n71CNV Loss21882294
    nsv894387CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARRDC1
    DNA2.0 Custom Variant and Variant Library Synthesis for ARRDC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARRDC1 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with ARRDC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. I9-arrestin 1 (ARRDC1) and I^-arrestins cooperate to mediate Notch degradation in mammals. (PubMed id 23886940)1, 3 Puca L....Brou C. (J. Cell. Sci. 2013)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    4. Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein. (PubMed id 22315426)1 Nabhan J.F....Lu Q. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    5. Mammalian I+ arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with I^ arrestins. (PubMed id 23236378)1 Shea F.F....Alvarez C.E. (PLoS ONE 2012)
    6. Multiple interactions between the ESCRT machinery and arrestin-related proteins: implications for PPXY-dependent budding. (PubMed id 21191027)1 Rauch S. and Martin-Serrano J. (J. Virol. 2011)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 92714 HGNC: 28633 AceView: ARRDC1 Ensembl:ENSG00000197070 euGenes: HUgn92714
    ECgene: ARRDC1 H-InvDB: ARRDC1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARRDC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARRDC1 gene:
    Search GeneIP for patents involving ARRDC1

    GeneCards and IP:
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