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ARRB2 Gene

protein-coding   GIFtS: 65
GCID: GC17P004613

Arrestin, Beta 2


(Previous symbol: ARR2)
  See ARRB2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Arrestin, Beta 21 2     ARB22 3
ARR21 2 3     BARR22
Arrestin 31 2     beta-arrestin-22
Arrestin Beta-22 3     

External Ids:    HGNC: 7121   Entrez Gene: 4092   Ensembl: ENSG000001414807   OMIM: 1079415   UniProtKB: P321213   

Export aliases for ARRB2 gene to outside databases

Previous GC identifers: GC17P005040 GC17P004959 GC17P004564 GC17P004820 GC17P004560 GC17P004502


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARRB2 Gene:
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of
G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones,
neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit
beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may
play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated
from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors.
Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Mar 2012)

GeneCards Summary for ARRB2 Gene:
ARRB2 (arrestin, beta 2) is a protein-coding gene. Diseases associated with ARRB2 include whim syndrome. GO annotations related to this gene include ubiquitin protein ligase binding and receptor binding. An important paralog of this gene is SAG.

UniProtKB/Swiss-Prot: ARRB2_HUMAN, P32121
Function: Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both
receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to
the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding
appears to require additional receptor determinants exposed only in the active receptor conformation. The
beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs,
clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in
clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly
depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to
intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated
internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin
at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and
TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as
desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound
arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Mediates
endocytosis of CCR7 following ligation of CCL19 but not CCL21. Involved in internalization of P2RY1, P2RY4, P2RY6
and P2RY11 and ATP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of
OPRD1 and subsequent recycling or degradation. Involved in ubiquitination of IGF1R. Beta-arrestins function as
multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived
signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin
signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and
transits the intracellular compartment. Acts as signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2) and
MAPK10 (JNK3). ERK1/2 and JNK3 activated by the beta-arrestin scaffold are largely excluded from the nucleus and
confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Acts as
signaling scaffold for the AKT1 pathway. GPCRs for which the beta-arrestin-mediated signaling relies on both
ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the
beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective
beta-arrestin form (reciprocal regulation). Increases ERK1/2 signaling in AGTR1- and AVPR2-mediated activation
(reciprocal regulation). Involved in CCR7-mediated ERK1/2 signaling involving ligand CCL19. Is involved in
type-1A angiotensin II receptor/AGTR1-mediated ERK activity. Is involved in type-1A angiotensin II
receptor/AGTR1-mediated MAPK10 activity. Is involved in dopamine-stimulated AKT1 activity in the striatum by
disrupting the association of AKT1 with its negative regulator PP2A. Involved in AGTR1-mediated chemotaxis.
Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent
chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine
stimulation by interacting with and stabilizing CHUK. Suppresses UV-induced NF-kappa-B-dependent activation by
interacting with CHUK. The function is promoted by stimulation of ADRB2 and dephosphorylation of ARRB2. Involved
in p53/TP53-mediated apoptosis by regulating MDM2 and reducing the MDM2-mediated degradation of p53/TP53. May
serve as nuclear messenger for GPCRs. Upon stimulation of OR1D2, may be involved in regulation of gene expression
during the early processes of fertilization. Also involved in regulation of receptors other than GPCRs. Involved
in endocytosis of TGFBR2 and TGFBR3 and down-regulates TGF-beta signaling such as NF-kappa-B activation. Involved
in endocytosis of low-density lipoprotein receptor/LDLR. Involved in endocytosis of smoothened homolog/Smo, which
also requires ADRBK1. Involved in endocytosis of SLC9A5. Involved in endocytosis of ENG and subsequent
TGF-beta-mediated ERK activation and migration of epithelial cells. Involved in Toll-like receptor and IL-1
receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization
required for activation of NF-kappa-B and JUN. Involved in insulin resistance by acting as insulin-induced
signaling scaffold for SRC, AKT1 and INSR. Involved in regulation of inhibitory signaling of natural killer cells
by recruiting PTPN6 and PTPN11 to KIR2DL1. Involved in IL8-mediated granule release in neutrophils. Involved in
the internalization of the atypical chemokine receptor ACKR3

Gene Wiki entry for ARRB2 (Arrestin beta 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARRB2 gene promoter:
         COUP-TF1   COUP-TF   AP-1   ATF-2   COUP   c-Jun   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARRB2 promoter sequence
   Search Chromatin IP Primers for ARRB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARRB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13

ARRB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARRB2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P004613:  view genomic region     (about GC identifiers)

Start:
4,613,784 bp from pter      End:
4,624,795 bp from pter
Size:
11,012 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARRB2_HUMAN, P32121 (See protein sequence)
Recommended Name: Beta-arrestin-2  
Size: 409 amino acids; 46106 Da
Subunit: Homooligomer; the self-association is mediated by InsP6-binding (Probable). Heterooligomer with ARRB1;
the association is mediated by InsP6-binding. Interacts with ADRB2 AND CHRM2. Interacts with PDE4A. Interacts
with PDE4D. Interacts with MAPK10, MAPK1 and MAPK3. Interacts with DRD2. Interacts with FSHR. Interacts with
CLTC. Interacts with HTR2C. Interacts with CCR5. Interacts with CXCR4. Interacts with SRC. Interacts with DUSP16;
the interaction is interrupted by stimulation of AGTR1 and activation of MAPK10. Interacts with CHUK; the
interaction is enhanced stimulation of ADRB2. Interacts with RELA. Interacts with MDM2; the interaction is
enhanced by activation of GPCRs. Interacts with SLC9A5. Interacts with TRAF6. Interacts with IGF1R. Interacts
with ENG. Interacts with KIR2DL1, KIR2DL3 and KIR2DL4. Interacts with LDLR. Interacts with AP2B1. Interacts with
C5AR1. Interacts with RAF1. Interacts with MAP2K1. Interacts with MAPK1. Interacts with MAPK10; the interaction
enhances MAPK10 activation by MAP3K5. Interacts with MAP2K4; the interaction is enhanced by presence of MAP3K5
and MAPK10. Interacts with MAP3K5. Interacts with AKT1. Interacts with IKBKB and MAP3K14. Interacts with SMO
(activated). Interacts with GSK3A and GSK3B. Associates with protein phosphatase 2A (PP2A) (By similarity).
Interacts with DHX8; the interaction is detected in the nucleus upon OR1D2 stimulation. Interacts with GAPDHS;
the interaction is detected in the nucleus upon OR1D2 stimulation. Interacts with H2AFX; the interaction is
detected in the nucleus upon OR1D2 stimulation. Interacts with KIF14; the interaction is detected in the nucleus
upon OR1D2 stimulation. Interacts with RCC1; the interaction is detected in the nucleus upon OR1D2 stimulation.
Interacts with CXCR4; the interaction is dependent on C-terminal phosphorylation of CXCR4 and allows activation
of MAPK1 and MAPK3. Interacts with GPR143. Interacts with HCK and CXCR1 (phosphorylated). Interacts with ACKR3
and ACKR4
Secondary accessions: B4DLW0 B5B0C0 B7WPL3 D3DTK2 H0Y688 Q0Z8D3 Q2PP19 Q6ICT3 Q8N7Y2 Q9UEQ6
Alternative splicing: 5 isoforms:  P32121-1   P32121-3   P32121-2   P32121-4   P32121-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARRB2: NX_P32121

Explore proteomics data for ARRB2 at MOPED

Post-translational modifications: 

  • Phosphorylated at Thr-382 in the cytoplasm; probably dephosphorylated at the plasma membrane. The phosphorylation
    does not regulate internalization and recycling of ADRB2, interaction with clathrin or AP2B11
  • The ubiquitination status appears to regulate the formation and trafficking of beta-arrestin-GPCR complexes and
    signaling. Ubiquitination appears to occurr GPCR-specifc. Ubiquitinated by MDM2; the ubiquitination is required
    for rapid internalization of ADRB2. Deubiquitinated by USP33; the deubiquitination leads to a dissociation of the
    beta-arrestin-GPCR complex. Stimulation of a class A GPCR, such as ADRB2, induces transient ubiquitination and
    subsequently promotes association with USP33. Stimulation of a class B GPCR promotes a sustained ubiquitination1
  • Hydroxylation by PHD2 modulates the rate of internalization by slowing down recruitment to the plasma membrane and
    inhibiting subsequent co-internalization with class A receptors1
  • Ubiquitination2 at Lys78
  • Modification sites at PhosphoSitePlus

  • See ARRB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001244257.1  NP_001244258.1  NP_001244259.1  NP_001244260.1  NP_004304.1  NP_945355.1  

    ENSEMBL proteins: 
     ENSP00000269260   ENSP00000458371   ENSP00000466344   ENSP00000341895   ENSP00000465296  
     ENSP00000458946   ENSP00000370898   ENSP00000403701   ENSP00000465877   ENSP00000466857  
     ENSP00000460879   ENSP00000460607  
    Reactome Protein details: P32121

    ARRB2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for ARRB2
    OriGene Custom MassSpec
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    Novus Biologicals ARRB2 Proteins
    Novus Biologicals ARRB2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ARRB2 

    ARRB2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals ARRB2 Antibodies
    Abcam antibodies for ARRB2
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for ARRB2
    LSBio Antibodies in human, mouse, rat for ARRB2

    ARRB2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for ARRB2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ARRB2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR014756 Ig_E-set
     IPR011022 Arrestin_C-like
     IPR014753 Arrestin_N
     IPR000698 Arrestin
     IPR014752 Arrestin_C

    Graphical View of Domain Structure for InterPro Entry P32121

    ProtoNet protein and cluster: P32121

    1 Blocks protein domain: IPB000698 Arrestin

    UniProtKB/Swiss-Prot: ARRB2_HUMAN, P32121
    Domain: The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction the AP-2 complex subunit AP2B1 (By
    similarity)
    Similarity: Belongs to the arrestin family


    Find genes that share domains with ARRB2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARRB2_HUMAN, P32121
    Function: Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both
    receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to
    the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding
    appears to require additional receptor determinants exposed only in the active receptor conformation. The
    beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs,
    clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in
    clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly
    depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to
    intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated
    internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin
    at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and
    TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as
    desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound
    arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Mediates
    endocytosis of CCR7 following ligation of CCL19 but not CCL21. Involved in internalization of P2RY1, P2RY4, P2RY6
    and P2RY11 and ATP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of
    OPRD1 and subsequent recycling or degradation. Involved in ubiquitination of IGF1R. Beta-arrestins function as
    multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived
    signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin
    signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and
    transits the intracellular compartment. Acts as signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2) and
    MAPK10 (JNK3). ERK1/2 and JNK3 activated by the beta-arrestin scaffold are largely excluded from the nucleus and
    confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Acts as
    signaling scaffold for the AKT1 pathway. GPCRs for which the beta-arrestin-mediated signaling relies on both
    ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the
    beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective
    beta-arrestin form (reciprocal regulation). Increases ERK1/2 signaling in AGTR1- and AVPR2-mediated activation
    (reciprocal regulation). Involved in CCR7-mediated ERK1/2 signaling involving ligand CCL19. Is involved in
    type-1A angiotensin II receptor/AGTR1-mediated ERK activity. Is involved in type-1A angiotensin II
    receptor/AGTR1-mediated MAPK10 activity. Is involved in dopamine-stimulated AKT1 activity in the striatum by
    disrupting the association of AKT1 with its negative regulator PP2A. Involved in AGTR1-mediated chemotaxis.
    Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent
    chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine
    stimulation by interacting with and stabilizing CHUK. Suppresses UV-induced NF-kappa-B-dependent activation by
    interacting with CHUK. The function is promoted by stimulation of ADRB2 and dephosphorylation of ARRB2. Involved
    in p53/TP53-mediated apoptosis by regulating MDM2 and reducing the MDM2-mediated degradation of p53/TP53. May
    serve as nuclear messenger for GPCRs. Upon stimulation of OR1D2, may be involved in regulation of gene expression
    during the early processes of fertilization. Also involved in regulation of receptors other than GPCRs. Involved
    in endocytosis of TGFBR2 and TGFBR3 and down-regulates TGF-beta signaling such as NF-kappa-B activation. Involved
    in endocytosis of low-density lipoprotein receptor/LDLR. Involved in endocytosis of smoothened homolog/Smo, which
    also requires ADRBK1. Involved in endocytosis of SLC9A5. Involved in endocytosis of ENG and subsequent
    TGF-beta-mediated ERK activation and migration of epithelial cells. Involved in Toll-like receptor and IL-1
    receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization
    required for activation of NF-kappa-B and JUN. Involved in insulin resistance by acting as insulin-induced
    signaling scaffold for SRC, AKT1 and INSR. Involved in regulation of inhibitory signaling of natural killer cells
    by recruiting PTPN6 and PTPN11 to KIR2DL1. Involved in IL8-mediated granule release in neutrophils. Involved in
    the internalization of the atypical chemokine receptor ACKR3

         Genatlas biochemistry entry for ARRB2:
    beta-arrestin 2,Ca2+ binding protein of the retinal red outer segments,widely expressed,binding to P-rhodopsin and
    inhibiting further G protein activation desensitized receptor-arrestin complex and sequestered through clathrin
    coated pits,also regulator of beta-adrenergic receptor A and involved in synaptic transmission in photoreceptor
    cells

         Gene Ontology (GO): Selected molecular function terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664G-protein coupled receptor binding IPI10644702
    GO:0005102receptor binding IPI18604210
    GO:0005515protein binding IPI12958365
    GO:0019904protein domain specific binding IEA--
    GO:0031625ubiquitin protein ligase binding IPI15878855
         
    Find genes that share ontologies with ARRB2           About GenesLikeMe


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Arrb2):
     behavior/neurological  cellular  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  mortality/aging  nervous system  respiratory system 

    Find genes that share phenotypes with ARRB2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Arrb2tm1Rjl for ARRB2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARRB2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARRB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARRB2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARRB2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ARRB2:
    hsa-mir-615-3p (MIRT039876), hsa-mir-149-5p (MIRT045486), hsa-mir-330-5p (MIRT038258)

    Block miRNA regulation of human, mouse, rat ARRB2 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate ARRB2:
    hsa-miR-365 hsa-miR-4271 hsa-miR-491-3p hsa-miR-483-3p hsa-miR-199a-5p hsa-miR-199b-5p hsa-miR-155 hsa-miR-1825
    SwitchGear 3'UTR luciferase reporter plasmidARRB2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARRB2

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): ARRB2 (NM_004313)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARRB2

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARRB2

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12159) for ARRB2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARRB2_HUMAN, P32121: Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit (By similarity).
    Cytoplasmic vesicle. Note=Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytosol4
    cytoskeleton2
    endosome2
    endoplasmic reticulum1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA16820410
    GO:0005737cytoplasm IDA12958365
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--

    Find genes that share ontologies with ARRB2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARRB2 About   (see all 34)  
    See pathways by source

    SuperPathContained pathways About
    1ADP signalling through P2Y purinoceptor 12
    Thrombin signalling through proteinase activated receptors (PARs)0.69
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.34
    Development Angiotensin signaling via beta Arrestin0.39
    2MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    3Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    4Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 HD Domain Mutants in Cancer0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH1 in Cancer0.79
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH10.79
    Signaling by NOTCH0.64
    5beta-catenin independent WNT signaling
    beta-catenin independent WNT signaling0.79
    Signaling by Wnt0.79


    Find genes that share SuperPaths with ARRB2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ARRB2
        Chemokine Signaling
    NK1R-mediated Non-Apoptotic PCD
    cAMP Pathway

    2 Cell Signaling Technology (CST) Pathways for ARRB2
        Wnt / Hedgehog / Notch
    Tyrosine Kinases / Adaptors

    2 GeneGo (Thomson Reuters) Pathways for ARRB2
        Development Angiotensin signaling via beta-Arrestin
    Cytoskeleton remodeling RalA regulation pathway

    Selected BioSystems Pathways for ARRB2 (see all 16)
        Myometrial Relaxation and Contraction Pathways
    MAPK signaling pathway
    Calcium Regulation in the Cardiac Cell
    TGF-beta Receptor Signaling Pathway
    Wnt Signaling Pathway NetPath


    3 Reactome Pathways for ARRB2
        Thrombin signalling through proteinase activated receptors (PARs)
    WNT5A-dependent internalization of FZD4
    Activated NOTCH1 Transmits Signal to the Nucleus

    2 PharmGKB Pathways for ARRB2
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Diuretics Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for ARRB2) (see all 7):
        MAPK signaling pathway
    Chemokine signaling pathway
    Endocytosis
    Dopaminergic synapse
    Olfactory transduction

        Pathway & Disease-focused RT2 Profiler PCR Array including ARRB2: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ARRB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARRB2 (P321211, 2, 3 ENSP000002692604) via UniProtKB, MINT, STRING, and/or I2D (see all 785)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    ENSG00000232804P081073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 44):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001932regulation of protein phosphorylation ----
    GO:0001934positive regulation of protein phosphorylation ----
    GO:0002031G-protein coupled receptor internalization IMP12582207
    GO:0002032desensitization of G-protein coupled receptor protein signaling pathway by arrestin IMP12582207
    GO:0002092positive regulation of receptor internalization IMP--

    Find genes that share ontologies with ARRB2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARRB2

    10 Novoseek inferred chemical compound relationships for ARRB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    etorphine 54.6 3 12860981 (1), 16115983 (1)
    threonine 32.2 3 17363685 (2), 19846537 (1)
    serine 31 4 17363685 (2), 18096696 (1), 19846537 (1)
    morphine 28.9 14 19071087 (4), 19477204 (2), 16115983 (1), 15849022 (1)
    isoproterenol 19.9 2 16051698 (2)
    opiate 14.9 4 14969742 (3)
    dopamine 8.2 2 15849022 (1), 18768802 (1)
    glycogen 4.88 1 19366991 (1)
    tyrosine 4.86 1 19828694 (1)
    atp 0 3 15728711 (2)



    Find genes that share compounds with ARRB2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for ARRB2 gene (6 alternative transcripts): 
    NM_001257328.1  NM_001257329.1  NM_001257330.1  NM_001257331.1  NM_004313.3  NM_199004.1  

    Unigene Cluster for ARRB2:

    Arrestin, beta 2
    Hs.435811  [show with all ESTs]
    Unigene Representative Sequence: NM_001257328
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000269260(uc002fyj.3 uc002fyk.3 uc002fyl.3 uc010vsg.2 uc002fym.3 uc002fyn.3)
    ENST00000574502 ENST00000574954 ENST00000570718 ENST00000570739 ENST00000346341
    ENST00000572457 ENST00000574888 ENST00000575131 ENST00000571791 ENST00000572497
    ENST00000573886 ENST00000381488 ENST00000412477 ENST00000571428 ENST00000575877
    ENST00000576235 ENST00000572782
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    Additional mRNA sequence: 

    AB209786.1 AF106941.1 AK097542.1 AK290951.1 AK297059.1 AK297181.1 BC007427.2 BC039066.1 
    BC067368.1 BC095450.1 CR450310.1 CR749218.1 DQ664180.1 EU883572.1 NR_047516.1 Z11501.1 

    20 DOTS entries:

    DT.446214  DT.100795649  DT.100029380  DT.95260342  DT.95260334  DT.95260335  DT.120918219  DT.100029379 
    DT.101975712  DT.91826805  DT.92439000  DT.92439012  DT.100834184  DT.120918187  DT.120918230  DT.120918276 
    DT.92439001  DT.95260344  DT.40131620  DT.91690247 

    Selected AceView cDNA sequences (see all 275):

    BM684533 CR619621 CA448696 BQ212507 BQ437671 BM927095 CR591682 BU626617 
    BM919126 BU681734 AI333725 BM987156 AL565497 AI339422 BU541413 BQ925857 
    CR749218 CB140260 CR620652 BM851989 AI817214 CR609288 AW263034 BU185085 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARRB2 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16
    SP1:                                                                                -           -                                             
    SP2:                          -                                                                                                               
    SP3:              -     -     -                                                                                                               
    SP4:              -     -     -     -     -     -     -     -                                                                                 
    SP5:                    -     -                                                                                                               


    ECgene alternative splicing isoforms for ARRB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ARRB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ARRB2 Expression
    About this image

    ARRB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARRB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435811
        Pathway & Disease-focused RT2 Profiler PCR Array including ARRB2: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARRB2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arrb21 , 5 arrestin, beta 21, 5 88.97(n)1
    95.24(a)1
      11 (42.99 cM)5
    2168691  NM_001271358.11  NP_001258287.11 
     704326355 
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3980462 cone arrestin 72.97(n)    L40463.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc640072 similar to arrestin, beta 2 79.36(n)   394099  BC054595.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta krz3   -- 56(a)
    (best of 3)
      100E3   --
    worm
    (Caenorhabditis elegans)
    Secernentea arr-13 beta-arrestin 52(a)     --


    ENSEMBL Gene Tree for ARRB2 (if available)
    TreeFam Gene Tree for ARRB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARRB2 gene
    SAG2  ARR32  ARRB12  
    6 SIMAP similar genes for ARRB2 using alignment to 7 protein entries:     ARRB2_HUMAN (see all proteins):
    DKFZp686L0365    ARRB1    ARR3    DKFZp686J1593    SAG    DKFZp686I1383

    Find genes that share paralogs with ARRB2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for ARRB2 (see all 423)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs20894801,2
    C,F,H--4611799(+) TACTAC/G/TAGCTC 7 -- us2k122NS EA NA 2644
    rs770019781,2
    C,F--4611801(+) CTACAG/ACTCAT 7 -- us2k12Minor allele frequency- A:0.10CSA WA 120
    rs786087531,2
    C,F--4611810(+) ATAAAG/AGCAGT 7 -- us2k11Minor allele frequency- A:0.01NA 120
    rs762804131,2
    C,F--4611812(+) AAAGGC/AAGTGT 7 -- us2k12Minor allele frequency- A:0.07WA 120
    rs1470246001,2
    --4611813(+) AAGGCA/GGTGTA 7 -- us2k10--------
    rs1476738371,2
    --4611818(+) AGTGTA/TGACCC 7 -- us2k10--------
    rs1849792511,2
    --4611830(+) AAAAAC/GGAGCA 7 -- us2k10--------
    rs1422413641,2
    C--4611835(+) GGAGCA/CGCAGC 7 -- us2k10--------
    rs23261171,2
    C,F,H--4611839(+) CAGCAG/ACAAGA 7 -- us2k110Minor allele frequency- A:0.07NS EA NA WA CSA 663
    rs1461164221,2
    --4611843(+) AGCAAA/GATTTA 7 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARRB2 (4613784 - 4624795 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ARRB2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2328716CNV Deletion18987734
    esv2715557CNV Deletion23290073
    esv995819CNV Deletion20482838
    nsv833346CNV Loss17160897
    nsv111849CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 107941    OMIM disorders: --

    1 disease for ARRB2:    
    About MalaCards
    whim syndrome

    1 disease from the University of Copenhagen DISEASES database for ARRB2:
    Pain agnosia

    Find genes that share disorders with ARRB2           About GenesLikeMe

    6 Novoseek inferred disease relationships for ARRB2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinal degeneration 42.3 3 16835270 (3)
    retinopathy 19.5 2 8733141 (1)
    asthma allergic 15 1 12925697 (1)
    asthma 0 1 12925697 (1)
    tumors 0 1 12488444 (1)
    heart failure 0 2 8293560 (2)

    Genetic Association Database (GAD): ARRB2
    Human Genome Epidemiology (HuGE) Navigator: ARRB2 (19 documents)

    Export disorders for ARRB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARRB2 gene, integrated from 10 sources (see all 321):
    (articles sorted by number of sources associating them with ARRB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosome mapping of the human arrestin (SAG), beta-arrestin 2 (ARRB2), and beta-adrenergic receptor kinase 2 (ADRBK2) genes. (PubMed id 7695743)1, 3, 9 Calabrese G....De Blasi A. (Genomics 1994)
    2. Beta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2. (PubMed id 12488444)1, 2, 9 Wang P.... Pei G. (J. Biol. Chem. 2003)
    3. Beta-arrestins 1 and 2 are associated with nicotine dependence in European American smokers. (PubMed id 17579607)1, 4, 9 Sun D....Li M.D. (Mol. Psychiatry 2008)
    4. The coding-synonymous polymorphism rs1045280 (Ser280Ser) in beta-arrestin 2 (ARRB2) gene is associated with tardive dyskinesia in Chinese patients with schizophrenia. (PubMed id 19049562)1, 4, 9 Liou Y.J....Lai I.C. (Eur. J. Neurol. 2008)
    5. Possible association of beta-arrestin 2 gene with methamphetamine use disorder, but not schizophrenia. (PubMed id 17233643)1, 4, 9 Ikeda M....Iwata N. (Genes Brain Behav. 2007)
    6. Activity-dependent internalization of smoothened mediated by beta- arrestin 2 and GRK2. (PubMed id 15618519)1, 2, 9 Chen W.... Lefkowitz R.J. (Science 2004)
    7. Dynamic interaction between the dual specificity phosphatase MKP7 and the JNK3 scaffold protein beta-arrestin 2. (PubMed id 15888437)1, 2, 9 Willoughby E.A. and Collins M.K. (J. Biol. Chem. 2005)
    8. A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex. (PubMed id 19782076)1, 2, 9 Li X.... Baillie G.S. (FEBS Lett. 2009)
    9. Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis. (PubMed id 15635042)1, 2, 9 Hunton D.L.... Lefkowitz R.J. (Mol. Pharmacol. 2005)
    10. {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. (PubMed id 15878855)1, 2, 9 Girnita L.... Larsson O. (J. Biol. Chem. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 409 HGNC: 712 AceView: ARRB2 Ensembl:ENSG00000141480 euGenes: HUgn409
    ECgene: ARRB2 Kegg: 409 H-InvDB: ARRB2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARRB2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ARRB2 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Arrestin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARRB2 gene:
    Search GeneIP for patents involving ARRB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for ARRB2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARRB2
     SwitchGear 3'UTR luciferase reporter plasmids for ARRB2
     SwitchGear Promoter luciferase reporter plasmids for ARRB2
     ThermoFisher Antibodies for ARRB2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARRB2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARRB2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARRB2
     LSBio Antibodies in human, mouse, rat for ARRB2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for ARRB2
      Search eBioscience for proteins for ARRB2
      Search eBioscience for elisas for ARRB2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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