ARRB1 Gene
protein-coding GIFtS : 61 GCID: GC11 M074976
arrestin, beta 1 ARR1 )
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Aliasesfor ARRB1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Arrestin, Beta 1 1 2 ARR11 2 3 ARB12 Arrestin 22 Beta-Arrestin-11 Arrestin Beta-13
Export aliases for ARRB1 gene to outside databases Previous GC identifers: GC11M077303 GC11M076515 GC11M075199 GC11M074702 GC11M074654 GC11M071275
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Summariesfor ARRB1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ARRB1 : Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. (provided by RefSeq, Jan 2011) UniProtKB/Swiss-Prot: ARRB1_HUMAN, P49407 Function : Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating bothreceptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Involved in internalization of P2RY4 and UTP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 ands subsequent recycling. Involved in the degradation of cAMP by recruiting cAMP phosphodiesterases to ligand-activated receptors. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2). ERK1/2 activated by the beta-arrestin scaffold is largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Recruits c-Src/SRC to ADRB2 resulting in ERK activation. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Inhibits ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Is required for SP-stimulated endocytosis of NK1R and recruits c-Src/SRC to internalized NK1R resulting in ERK1/2 activation, which is required for the antiapoptotic effects of SP. Is involved in proteinase-activated F2RL1-mediated ERK activity. Acts as signaling scaffold for the AKT1 pathway. Is involved in alpha-thrombin-stimulated AKT1 signaling. Is involved in IGF1-stimulated AKT1 signaling leading to increased protection from apoptosis. Involved in activation of the p38 MAPK signaling pathway and in actin bundle formation. Involved in F2RL1-mediated cytoskeletal rearrangement and chemotaxis. Involved in AGTR1-mediated stress fiber formation by acting together with GNAQ to activate RHOA. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. May serve as nuclear messenger for GPCRs. Involved in OPRD1-stimulated transcriptional regulation by translocating to CDKN1B and FOS promoter regions and recruiting EP300 resulting in acetylation of histone H4. Involved in regulation of LEF1 transcriptional activity via interaction with DVL1 and/or DVL2 Also involved in regulation of receptors other than GPCRs. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Binds phosphoinositides. Binds inositolhexakisphosphate (InsP6) (By similarity). Involved in IL8-mediated granule release in neutrophils Gene Wiki entry for ARRB1 (Arrestin beta 1)
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Genomic Viewsfor ARRB1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_167190.1 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ARRB1 gene promoter:ER-alpha GR HFH-3 Elk-1 AML1a GR-beta FOXI1 SRY GR-alpha Other transcription factors Search SABiosciences Chromatin IP Primers for ARRB1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.4 HGNC cytogenetic band: 11q13 ARRB1 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11M074976: view genomic region
(about GC identifiers )
Start: 74,975,226 bp from pter End:
75,062,873 bp from pter
Size: 87,648 bases Orientation:
minus strand
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Proteinsfor ARRB1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ARRB1_HUMAN, P49407 See
protein sequence )Recommended Name: Size : 418 amino acids; 47066 DaSubunit : Monomer. Homodimer. Homooligomer; the self-association is mediated by InsP6-binding. Heterooligomer withARRB2; the association is mediated by InsP6-binding. Interacts with GPR143. Interacts with ADRB2 (phosphorylated). Interacts with CHRM2 (phosphorylated). Interacts with LHCGR. Interacts with CYTH2 and CASR. Interacts with AP2B1 (dephosphorylated at 'Tyr-737'); phosphorylation of AP2B1 at 'Tyr-737' disrupts the interaction. Interacts (dephosphorylated at Ser-412) with CLTC. Interacts with CCR2 and ADRBK1. Interacts with CRR5. Interacts with PTAFR (phosphorylated on serine residues). Interacts with CLTC and MAP2K3. Interacts with CREB1. Interacts with TRAF6. Interacts with IGF1R and MDM2. Interacts with C5AR1. Interacts with PDE4D. Interacts with SRC (via the SH3 domain and the protein kinase domain); the interaction is independent of the phosphorylation state of SRC C-terminus. Interacts with TACR1. Interacts with RAF1. Interacts with CHUK, IKBKB and MAP3K14. Interacts with DVL1; the interaction is enhanced by phosphorylation of DVL1. Interacts with DVL2; the interaction is enhanced by phosphorylation of DVL2. Interacts with IGF1R. Associates with MAP kinase p38. Part of a MAPK signaling complex consisting of TACR1, ARRB1, SRC, MAPK1 (activated) and MAPK3 (activated). Part of a MAPK signaling complex consisting of F2RL1, ARRB1, RAF1, MAPK1 (activated) and MAPK3 (activated) (By similarity). Interacts with MAP2K4/MKK4. Interacts with HCK and CXCR1 (phosphorylated)
Subcellular location : Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit (Probable). Cell projection,pseudopodium (By similarity). Cytoplasmic vesicle. Note=Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. The monomeric form is predominantly located in the nucleus. The oligomeric form is located in the cytoplasm. Translocates to the nucleus upon stimulation of OPRD1 (By similarity)
1 PDB 3D structure from :2IV8 (3D) Secondary accessions : B6V9G8 O75625 O75630 Q2PP20 Q9BTK8Alternative splicing : 2 isoforms : P49407-1 P49407-2 Explore the universe of human proteins at neXtProt for ARRB1: NX_P49407 Post-translational modifications:
Constitutively phosphorylated at Ser-412 in the cytoplasm. At the plasma membrane, is rapidly dephosphorylated, a process that is required for clathrin binding and ADRB2 endocytosis but not for ADRB2 binding and desensitization. Once internalized, is rephosphorylated1
The ubiquitination status appears to regulate the formation and trafficking of beta-arrestin-GPCR complexes and signaling. Ubiquitination appears to occur GPCR-specific. Ubiquitinated by MDM2; the ubiquitination is required for rapid internalization of ADRB2. Deubiquitinated by USP33; the deubiquitination leads to a dissociation of the beta-arrestin-GPCR complex. Stimulation of a class A GPCR, such as ADRB2, induces transient ubiquitination and subsequently promotes association with USP331
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P49407 ARRB1 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (2 alternative transcripts): NP_004032.2 NP_064647.1 ENSEMBL proteins: ENSP00000409581 ENSP00000353124 ENSP00000436530 ENSP00000433171 ENSP00000434196 ENSP00000436352 ENSP00000433137 ENSP00000377141 Reactome Protein details: P49407 Human Recombinant Protein Products: Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13 ): About this table
About GeneDecksing ARRB1 Antibody Products: Assay Products for ARRB1:
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Protein
Domains /for ARRB1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5/7 InterPro domains/families (see all 7 ):
Graphical View of Domain Structure for InterPro Entry P49407 ProtoNet protein and cluster: P49407
1 Blocks protein family : IPB000698 UniProtKB/Swiss-Prot: ARRB1_HUMAN, P49407 Domain : The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction the AP-2 complex subunit AP2B1 (By similarity).Binding to phosphorylated GPCRs induces a conformationanl change that exposes the motif to the surface Domain : The N-terminus binds InsP6 with low affinity (By similarity)Domain : The C-terminus binds InsP6 with high affinity (By similarity)Similarity : Belongs to the arrestin family
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Functionfor ARRB1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ARRB1_HUMAN, P49407 Function : Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating bothreceptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Involved in internalization of P2RY4 and UTP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 ands subsequent recycling. Involved in the degradation of cAMP by recruiting cAMP phosphodiesterases to ligand-activated receptors. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2). ERK1/2 activated by the beta-arrestin scaffold is largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Recruits c-Src/SRC to ADRB2 resulting in ERK activation. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Inhibits ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Is required for SP-stimulated endocytosis of NK1R and recruits c-Src/SRC to internalized NK1R resulting in ERK1/2 activation, which is required for the antiapoptotic effects of SP. Is involved in proteinase-activated F2RL1-mediated ERK activity. Acts as signaling scaffold for the AKT1 pathway. Is involved in alpha-thrombin-stimulated AKT1 signaling. Is involved in IGF1-stimulated AKT1 signaling leading to increased protection from apoptosis. Involved in activation of the p38 MAPK signaling pathway and in actin bundle formation. Involved in F2RL1-mediated cytoskeletal rearrangement and chemotaxis. Involved in AGTR1-mediated stress fiber formation by acting together with GNAQ to activate RHOA. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. May serve as nuclear messenger for GPCRs. Involved in OPRD1-stimulated transcriptional regulation by translocating to CDKN1B and FOS promoter regions and recruiting EP300 resulting in acetylation of histone H4. Involved in regulation of LEF1 transcriptional activity via interaction with DVL1 and/or DVL2 Also involved in regulation of receptors other than GPCRs. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Binds phosphoinositides. Binds inositolhexakisphosphate (InsP6) (By similarity). Involved in IL8-mediated granule release in neutrophils
Genatlas biochemistry entry for ARRB1 beta-arrestin 1,Ca2+ binding protein of the retinal red outer segments,widely expressed,binding to P-rhodopsin and inhibiting further G protein activation desensitized receptor-arrestin complex and sequestered through clathrin coated pits,also regulator of beta-adrenergic receptor A and involved in synaptic transmission in photoreceptor cells Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 5 )human mouse rat see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): ARRB1 (NM_004041 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARRB1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ARRB1
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARRB1
Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11 ): About this table
About GeneDecksing Animal Models: Arrb1 tm1Jse for ARRB18 MGI mutant phenotypes (inferred from 1 allele(MGI details for Arrb1) :About GeneDecksing
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Pathways & Interactionsfor ARRB1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/24 super-pathways (see all 24 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant 2 Clathrin derived vesicle budding 3 Platelet activation, signaling and aggregation 4 Activation of beta-arrestin-1-bound Src kinase 5 Development Angiotensin signaling via beta-Arrestin
Pathway sources See GeneCards unified pathways Show all pathways 2 3 2 2 5 5/22 (see all 22 )1 ARRB1 4 (Kegg details for ARRB1) :About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARRB1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/359 Interacting proteins for ARRB1 (P49407 1 , 2 , 3 ENSP00000377141 4 via UniProtKB, MINT, STRING , and/or I2D (see all 359 )About this table Gene Ontology (GO): 5/30 biological process terms (GO ID links to tree view) (see all 30 ): About this table
About GeneDecksing
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Drugs & Compoundsfor ARRB1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for ARRB1 9 Novoseek chemical compound relationships for ARRB1 gene About this table ARRB1
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Transcriptsfor ARRB1 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ARRB1 gene (2 alternative transcripts): NM_004041.4 NM_020251.3 Unigene Cluster for ARRB1:
Arrestin, beta 1 Hs.503284 [show with all ESTs ] Unigene Representative Sequence: NM_004041 13 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000420843 (uc001owe.2 uc001owf.2 ) ENST00000360025 ENST00000532447 ENST00000531012 ENST00000529741 ENST00000532525 ENST00000524400 ENST00000533609 ENST00000527385 ENST00000530086 ENST00000529280 ENST00000533255 ENST00000393505 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 5 )human mouse rat see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): ARRB1 (NM_004041 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARRB1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ARRB1
Additional cDNA sequence: AF084040.1 AF084940.1 AK074660.1 AK289718.1 AK293758.1 AL157484.1 BC003636.2 FJ348262.1 L04685.1
18 DOTS entries : DT.97839794 DT.95290767
DT.95077272 DT.100777614 DT.406001 DT.113437 DT.95239975 DT.120727057 DT.40297036 DT.85104858 DT.100688168 DT.120727023 DT.120727040 DT.120727066 DT.120727076 DT.120727079 DT.40193048 DT.40246233 24/265 AceView cDNA sequences (see all 265 ):
AA991658 AI274395 AI991686 AL550609 AI857697 BI489948 BX282347 CD516701 F03091 BF766189 AI682315 BF115243 AL547951 BM727743 AI432611 AI401658 BM924952 AW136216 CD629999 CD365532 BQ706648 CR620471 CR596009 BF766186 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ARRB1 (see all 6 ) About this scheme ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 SP1 : - - - - - - SP2 : - - - - - - - SP3 : - - SP4 : - SP5 :
ECgene alternative splicing isoforms for ARRB1
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Expression for ARRB1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ARRB1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AGGGCTTGGA
About this image ARRB1 expression in embryonic tissues and stem cells About this table See ARRB1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ARRB1 SOURCE GeneReport for Unigene cluster: Hs.503284 SABiosciences Expression via Pathway-Focused PCR Arrays including ARRB1 : Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARRB1
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Orthologsfor ARRB1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for ARRB1 gene from 3/19 species (see all 19 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
zebrafish Actinopterygii arrb11
arrestin, beta 1
76.63(n) 90.67(a)
553266 NM_001159822.1 NP_001153294.1
fruit fly Insecta krz1 3
kurtz1
65(a) 3 62.68(n) 1 65.9(a) 1
100E33 53554 1 NM_080249.4 1 NP_524988.1 1
worm Secernentea arr-11 3
beta-arrestin3 1
54(a) 3 57.84(n) 1 57.18(a) 1
180446 1 NM_075782.3 1 NP_508183.1 1
ENSEMBL Gene Tree for ARRB1 (if available)TreeFam Gene Tree for ARRB1 (if available)
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Paralogsfor ARRB1 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ARRB1 gene SAG 2 ARR3 2 ARRB2 2 6 SIMAP similar genes for ARRB1 using alignment to 7 protein entries: ARRB1_HUMAN (see all proteins ):ARRB2 DKFZp686L0365 ARR3 SAG DKFZp686J1593 DKFZp686I1383 About GeneDecksing
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Genomic Variantsfor ARRB1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 11 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for ARRB1 (74975226 - 75062873 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ARRB1: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor ARRB1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 107940
OMIM disorders : --19 : About MalaCards primary biliary cirrhosis nicotine dependence whim syndrome acute lymphoblastic leukemia multiple sclerosis lymphoblastic leukemia aldosteronism hematopoiesis pertussis ovarian cancer colorectal cancer thyroiditis leukemia lung cancer breast cancer glioblastoma retinitis pancreatitis neuronitis 7 Novoseek disease relationships for ARRB1 gene About this table
Human Genome Epidemiology (HuGE) Navigator: ARRB1 (6 documents) Export disorders for ARRB1 gene to outside databases
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Publicationsfor ARRB1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ARRB1 gene, integrated from 9 sources (see all 238 ):(articles sorted by number of sources associating them with ARRB1) Utopia : connect your pdf to the dynamic
Molecular analysis of human beta-arrestin-1: cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing. (PubMed id 8486659) 1 , 2 , 3, 9(1993) Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation. (PubMed id 16709866) 1 , 2 , 9(2006) beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. (PubMed id 15611106) 1 , 2 , 9(2005) {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. (PubMed id 15878855) 1 , 2 , 9(2005) Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2. (PubMed id 14711824) 1 , 2 , 9(2004) A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription. (PubMed id 16325578) 1 , 2 , 9(2005) Phosphorylation of key serine residues is required for internalization of the complement 5a (C5a) anaphylatoxin receptor via a beta-arrestin, dynamin, and clathrin-dependent pathway. (PubMed id 12464600) 1 , 2 , 9(2003) Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation. (PubMed id 16492667) 1 , 2 , 9(2006) Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. (PubMed id 9924018) 1 , 2 , 9(1999) Beta-arrestin1 phosphorylation by GRK5 regulates G pr otein-independent 5-HT4 receptor signalling. (PubMed id 19661922) 1 , 2 (2009)
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External Searches for ARRB1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ARRB1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ARRB1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing ARRB1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for ARRB1 Pharmacogenomics, SNPs, Pathways Wikipedia http://en.wikipedia.org/wiki/Arrestin
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About This Section Patent Information for ARRB1 gene: ARRB1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ARRB1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for ARRB1 OriGene shRNA RFP for ARRB1 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for ARRB1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ARRB1 OriGene 3'-UTR Clone for ARRB1 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ARRB1 OriGene Custom Protein Services for ARRB1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARRB1 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for ARRB1
Search Tocris compounds for ARRB1
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARRB1
ThermoFisher Antibodies for ARRB1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ARRB1
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and Proteopedia 
for ARRB1:
BioSystems Pathways for ARRB1 
PharmGKB Pathway for 
Kegg Pathways 
Browse Tocris compounds for 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
Curated
Microarrays
