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ARR3 Gene

protein-coding   GIFtS: 58
GCID: GC0XP069488

Arrestin 3, Retinal (X-Arrestin)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Arrestin 3, Retinal (X-Arrestin)1 2     C-arrestin2 3
Arrestin 41 2     X-arrestin2 3
Cone Arrestin2 3     cArr2 3
Retinal Cone Arrestin-32 3     arrestin-C2
ARRX2 3     CAR3

External Ids:    HGNC: 7101   Entrez Gene: 4072   Ensembl: ENSG000001205007   OMIM: 3017705   UniProtKB: P365753   

Export aliases for ARR3 gene to outside databases

Previous GC identifers: GC0XP065666 GC0XP066965 GC0XP067721 GC0XP068354 GC0XP069271 GC0XP069404 GC0XP063309


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ARR3 Gene:
ARR3 (arrestin 3, retinal (X-arrestin)) is a protein-coding gene. Diseases associated with ARR3 include retinal vasculitis, and vasculitis. GO annotations related to this gene include opsin binding and phosphoprotein binding. An important paralog of this gene is SAG.

UniProtKB/Swiss-Prot: ARRC_HUMAN, P36575
Function: May play a role in an as yet undefined retina-specific signal transduction. Could binds to
photoactivated-phosphorylated red/green opsins

Gene Wiki entry for ARR3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_011651.18  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARR3 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   Tal-1beta   E2F-1   E2F   ARP-1   AP-2alpha isoform 4   AP-2alpha   ITF-2   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARR3 promoter sequence
   Search Chromatin IP Primers for ARR3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xcen-q21   Ensembl cytogenetic band:  Xq13.1   HGNC cytogenetic band: Xq13.1

ARR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARR3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP069488:  view genomic region     (about GC identifiers)

Start:
69,488,155 bp from pter      End:
69,501,690 bp from pter
Size:
13,536 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARRC_HUMAN, P36575 (See protein sequence)
Recommended Name: Arrestin-C  
Size: 388 amino acids; 42778 Da
Subunit: Interacts with CXCR4; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and
modulates the calcium ion mobilization activity of CXCR4
2 PDB 3D structures from and Proteopedia for ARR3:
1XEH (3D)        2A34 (3D)    
Secondary accessions: B5B0B9 Q5JT23 Q5JT24 Q6IBF5 Q96EN2
Alternative splicing: 2 isoforms:  P36575-1   P36575-2   

Explore the universe of human proteins at neXtProt for ARR3: NX_P36575

Explore proteomics data for ARR3 at MOPED


See ARR3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_004303.2  
ENSEMBL proteins: 
 ENSP00000363619   ENSP00000425505   ENSP00000311538  

ARR3 Human Recombinant Protein Products:

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Cloud-Clone Corp. ELISAs for ARR3
Cloud-Clone Corp. CLIAs for ARR3


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Selected InterPro protein domains (see all 7):
 IPR014756 Ig_E-set
 IPR011022 Arrestin_C-like
 IPR014753 Arrestin_N
 IPR000698 Arrestin
 IPR014752 Arrestin_C

Graphical View of Domain Structure for InterPro Entry P36575

ProtoNet protein and cluster: P36575

1 Blocks protein domain: IPB000698 Arrestin

UniProtKB/Swiss-Prot: ARRC_HUMAN, P36575
Similarity: Belongs to the arrestin family


ARR3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ARRC_HUMAN, P36575
Function: May play a role in an as yet undefined retina-specific signal transduction. Could binds to
photoactivated-phosphorylated red/green opsins

     Genatlas biochemistry entry for ARR3:
X arrestin,expressed in the red-,green-,blue-sensitive cone photoreceptors modulator of cone phototransduction

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002046opsin binding IEA--
GO:0005515protein binding IPI16189514
GO:0051219phosphoprotein binding IEA--
     
ARR3 for ontologies           About GeneDecksing


Phenotypes:
     1 MGI mutant phenotype (inferred from 1 allele(MGI details for Arr3):
 vision/eye 

ARR3 for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARR3
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARR3

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARR3
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARR3

miRNA
Products:
    
miRTarBase miRNAs that target ARR3:
hsa-mir-132-3p (MIRT021808)

Block miRNA regulation of human, mouse, rat ARR3 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate ARR3
SwitchGear 3'UTR luciferase reporter plasmidARR3 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat ARR3

Gene Editing
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GenScript: all cDNA clones in your preferred vector: ARR3 (NM_004312)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARR3

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARR3


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol3
nucleus1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001750photoreceptor outer segment IEA--
GO:0005737cytoplasm TAS8224247
GO:0045202synapse IEA--

ARR3 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ARR3 About    
See pathways by source

SuperPathContained pathways About
1The phototransduction cascade
Visual signal transduction- Cones0.39
2Visual Cycle in Retinal Rods
Visual Cycle in Retinal Rods
3Thromboxane A2 receptor signaling
Thromboxane A2 receptor signaling
4CXCR4-mediated signaling events
CXCR4-mediated signaling events

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ARR3
    Visual Cycle in Retinal Rods

3 BioSystems Pathways for ARR3
    Visual signal transduction- Cones
Thromboxane A2 receptor signaling
CXCR4-mediated signaling events


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARR3
Interactions:

    GeneGlobe Interaction Network for ARR3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for ARR3 (P365751, 2, 3 ENSP000003115384) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
InteractantInteraction Details
GeneCardExternal ID(s)
CAPNS1P046322, 3, ENSP000002465334MINT-64400 I2D: score=5 STRING: ENSP00000246533
RNASE6Q930912, 3, ENSP000003020464MINT-64402 I2D: score=5 STRING: ENSP00000302046
MAP2K7O147332, 3, ENSP000003810664MINT-64399 I2D: score=4 STRING: ENSP00000381066
ZNF496Q96IT11, 2, 3, ENSP000002947534EBI-718116,EBI-743906 MINT-67526 I2D: score=6 STRING: ENSP00000294753
OPN1MWP040013, ENSP000003589514I2D: score=1 STRING: ENSP00000358951
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Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001932regulation of protein phosphorylation IEA--
GO:0006897endocytosis IEA--
GO:0007165signal transduction IEA--
GO:0007601visual perception IEA--

ARR3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ARR3 (ARRC)

4 Novoseek inferred chemical compound relationships for ARR3 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
calcium 42.3 60 9144337 (3), 11350736 (3), 14623314 (2), 12970324 (2) (see all 18)
threonine 8.91 1 9694886 (1)
retinoic acid 7.31 5 11980849 (2), 12601020 (1)
arachidonic acid 5.7 1 9144337 (1)



ARR3 for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ARR3 gene: 
NM_004312.2  

Unigene Cluster for ARR3:

Arrestin 3, retinal (X-arrestin)
Hs.308  [show with all ESTs]
Unigene Representative Sequence: NM_004312
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000374495(uc004dya.3) ENST00000477379 ENST00000480877 ENST00000307959(uc004dyb.2)

miRNA
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SwitchGear 3'UTR luciferase reporter plasmidARR3 3' UTR sequence
Inhib. RNA
Products:
     
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Predesigned siRNA for gene silencing in human, mouse, rat ARR3
Clone
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GenScript: all cDNA clones in your preferred vector: ARR3 (NM_004312)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARR3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARR3
Primer
Products:
    
OriGene qPCR primer pairs and template standards for ARR3
OriGene qSTAR qPCR primer pairs in human, mouse for ARR3
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARR3
  QuantiTect SYBR Green Assays in human, mouse, rat ARR3
  QuantiFast Probe-based Assays in human, mouse, rat ARR3

Additional mRNA sequence: 

AF033105.1 BC012096.1 CR456849.1 EU883571.1 U03626.1 

3 DOTS entries:

DT.440760  DT.95363472  DT.87046551 

Selected AceView cDNA sequences (see all 26):

BU740536 BU165421 BU733263 BM707744 BM713285 CR456849 BC012096 BG472156 
BM714746 BM725277 BM676400 U03626 AW954890 NM_004312 BM722855 AA047869 
AF033105 AL712046 AA019125 AA019124 AA053939 H38026 AA317479 BQ637477 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ARR3    About this scheme

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1:                                -                                             
SP2:                    -           -                                             
SP3:                                                                              
SP4:                                                                              


ECgene alternative splicing isoforms for ARR3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ARR3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGGCCGCTAG
ARR3 Expression
About this image


ARR3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Eye (Sensory Organs)    fully expand to see all 10 entries
         Mature L Cone Cells Outer Nuclear Layer
         Retina
         Photoreceptor-like cells
         corneal epithelial basal cells   
 
 Neurons
         Mature L Cone Cells Outer Nuclear Layer
 
 NULL (Sensory Organs)    fully expand to see all 3 entries
         Photoreceptor-like cells
 
 Epithelial Cells (Uncategorized)
         corneal epithelial basal cells   
ARR3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ARR3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.308

UniProtKB/Swiss-Prot: ARRC_HUMAN, P36575
Tissue specificity: Inner and outer segments, and the inner plexiform regions of the retina

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARR3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for ARR3 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Arr31 , 5 arrestin 3, retinal1, 5 85.65(n)1
83.69(a)1
  X (43.72 cM)5
1707351  NM_133205.31  NP_573468.11 
 1006054975 
chicken
(Gallus gallus)
Aves ARR31 arrestin 3, retinal 71.55(n)
70.16(a)
  769109  NM_001097533.1  NP_001091002.1 
lizard
(Anolis carolinensis)
Reptilia ARR36
arrestin 3, retinal (X-arrestin)
63(a)
1 ↔ 1
GL344027.1(4609-18806)
zebrafish
(Danio rerio)
Actinopterygii arr3a1 arrestin 3a, retinal (X-arrestin) 64.18(n)
60.74(a)
  436678  NM_001002405.1  NP_001002405.1 
fruit fly
(Drosophila melanogaster)
Insecta Arr13 deactivation of rhodopsin mediated
signaling metarhodopsin more
41(a)
(best of 2)
  36D3   --
worm
(Caenorhabditis elegans)
Secernentea arr-16
Protein ARR-1 (arr-1) mRNA, complete cds
41(a)
1 → many
X(950782-954233) WBGene00000195


ENSEMBL Gene Tree for ARR3 (if available)
TreeFam Gene Tree for ARR3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ARR3 gene
SAG2  ARRB22  ARRB12  
6 SIMAP similar genes for ARR3 using alignment to 2 protein entries:     ARRC_HUMAN (see all proteins):
ARRB1    ARRB2    DKFZp686I1383    DKFZp686J1593    SAG    DKFZp686L0365

ARR3 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ARR3 (see all 231)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs59368701,2
C,F,A,H--69486376(+) attcaT/Ctgagc 1 -- us2k17Minor allele frequency- C:0.27NS EA NA CSA 423
rs1388876061,2
--69486528(+) AGTAGA/GAAGAG 1 -- us2k10--------
rs9464511,2
C--69486614(-) AATGAC/TTAGTG 1 -- us2k18Minor allele frequency- T:0.00WA NA CSA 12
rs1503891161,2
--69486737(+) TGACTC/TTTCGC 1 -- us2k10--------
rs726288641,2
C--69486740(+) CTTTTC/TGCCTT 1 -- us2k10--------
rs1380246381,2
--69486742(+) TTTCGC/TCTTCC 1 -- us2k10--------
rs1841677891,2
--69486749(+) TTCCTC/TGCAGA 1 -- us2k10--------
rs1888655631,2
--69486847(+) TGCACC/TATCTG 1 -- us2k10--------
rs1909005911,2
--69486882(+) ATAGTA/GACTAA 1 -- us2k10--------
rs1825840821,2
--69486897(+) CCAGGA/CCCTGA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for ARR3 (69488155 - 69501690 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for ARR3:    About this table    
Variant IDTypeSubtypePubMed ID
nsv525258CNV Gain19592680
esv1584074OTHER Inversion17803354

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing ARR3
DNA2.0 Custom Variant and Variant Library Synthesis for ARR3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 301770    OMIM disorders: --

13 diseases for ARR3:    
About MalaCards
retinal vasculitis    vasculitis    parathyroid adenoma    retinitis
rheumatic disease    retinoblastoma    behcet's disease    leber congenital amaurosis
retinal degeneration    retinitis pigmentosa    adenoma    breast cancer
neuronitis


ARR3 for disorders           About GeneDecksing

2 Novoseek inferred disease relationships for ARR3 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma 31.7 6 11980849 (2), 15363854 (2), 12601020 (1)
tumors 4.5 1 12970324 (1)


Export disorders for ARR3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ARR3 gene, integrated from 10 sources (see all 83):
(articles sorted by number of sources associating them with ARR3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. X-arrestin: a new retinal arrestin mapping to the X chromosome. (PubMed id 8224247)1, 2, 3, 9 Murakami A.... Inana G. (FEBS Lett. 1993)
  2. Cone arrestin identified by targeting expression of a functional family. (PubMed id 8308033)1, 2, 9 Craft C.M.... Wiechmann A.F. (J. Biol. Chem. 1994)
  3. Isolation and characterization of the human X-arrestin gene. (PubMed id 9931451)1, 2, 9 Sakuma H.... Inana G. (Gene 1998)
  4. Immunolocalization of X-arrestin in human cone photoreceptors. (PubMed id 8612728)1, 2, 9 Sakuma H.... McLaren M.J. (FEBS Lett. 1996)
  5. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. Identification and light-dependent translocation of a cone-specific antigen, cone arrestin, recognized by monoclonal antibody 7G6. (PubMed id 12824223)1, 9 Zhang H....Baehr W. (amp 2003)
  8. Cone arrestin binding to JNK3 and Mdm2: conformational preference and localization of interaction sites. (PubMed id 17680991)1, 9 Song X....Gurevich V.V. (J. Neurochem. 2007)
  9. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. (PubMed id 17620599)1, 9 Xiao K....Lefkowitz R.J. (Proc. Natl. Acad. Sci. U.S.A. 2007)
  10. Loss of cone molecular markers in rhodopsin-mutant human retinas with retinitis pigmentosa. (PubMed id 11063754)1, 9 John S.K....Milam A.H. (Mol. Vis. 2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 407 HGNC: 710 AceView: ARR3 Ensembl:ENSG00000120500 euGenes: HUgn407
ECgene: ARR3 H-InvDB: ARR3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ARR3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ARR3 gene:
Search GeneIP for patents involving ARR3

GeneCards and IP:
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