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Aliases for ARR3 Gene

Aliases for ARR3 Gene

  • Arrestin 3, Retinal (X-Arrestin) 2 3
  • Retinal Cone Arrestin-3 3 4
  • Cone Arrestin 3 4
  • Arrestin 4 2 3
  • C-Arrestin 3 4
  • X-Arrestin 3 4
  • ARRX 3 4
  • CArr 3 4
  • Arrestin-C 3
  • CAR 4

External Ids for ARR3 Gene

Summaries for ARR3 Gene

GeneCards Summary for ARR3 Gene

ARR3 (Arrestin 3, Retinal (X-Arrestin)) is a Protein Coding gene. Diseases associated with ARR3 include retinal vasculitis and leber congenital amaurosis. Among its related pathways are CXCR4-mediated signaling events and Thromboxane A2 receptor signaling. GO annotations related to this gene include phosphoprotein binding and opsin binding. An important paralog of this gene is ARRB2.

UniProtKB/Swiss-Prot for ARR3 Gene

  • May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins

Gene Wiki entry for ARR3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARR3 Gene

Genomics for ARR3 Gene

Genomic Location for ARR3 Gene

Start:
70,268,305 bp from pter
End:
70,281,993 bp from pter
Size:
13,689 bases
Orientation:
Plus strand

Genomic View for ARR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARR3 Gene

Proteins for ARR3 Gene

  • Protein details for ARR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36575-ARRC_HUMAN
    Recommended name:
    Arrestin-C
    Protein Accession:
    P36575
    Secondary Accessions:
    • B5B0B9
    • Q5JT23
    • Q5JT24
    • Q6IBF5
    • Q96EN2

    Protein attributes for ARR3 Gene

    Size:
    388 amino acids
    Molecular mass:
    42778 Da
    Quaternary structure:
    • Interacts with CXCR4; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates the calcium ion mobilization activity of CXCR4.

    Three dimensional structures from OCA and Proteopedia for ARR3 Gene

    Alternative splice isoforms for ARR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARR3 Gene

Proteomics data for ARR3 Gene at MOPED

Post-translational modifications for ARR3 Gene

No Post-translational modifications

Other Protein References for ARR3 Gene

No data available for DME Specific Peptides for ARR3 Gene

Domains for ARR3 Gene

Protein Domains for ARR3 Gene

UniProtKB/Swiss-Prot:

ARRC_HUMAN
Family:
  • Belongs to the arrestin family.:
    • P36575
genes like me logo Genes that share domains with ARR3: view

No data available for Gene Families for ARR3 Gene

Function for ARR3 Gene

Molecular function for ARR3 Gene

GENATLAS Biochemistry: X arrestin,expressed in the red-,green-,blue-sensitive cone photoreceptors modulator of cone phototransduction
UniProtKB/Swiss-Prot Function: May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins

Gene Ontology (GO) - Molecular Function for ARR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002046 opsin binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0051219 phosphoprotein binding IEA --
genes like me logo Genes that share ontologies with ARR3: view

Phenotypes for ARR3 Gene

MGI mutant phenotypes for ARR3:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ARR3: view

miRNA for ARR3 Gene

miRTarBase miRNAs that target ARR3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARR3 Gene

Localization for ARR3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARR3 Gene COMPARTMENTS Subcellular localization image for ARR3 gene
Compartment Confidence
cytosol 3
nucleus 1

Gene Ontology (GO) - Cellular Components for ARR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001750 photoreceptor outer segment IEA --
GO:0001917 photoreceptor inner segment IDA 23704327
GO:0005737 cytoplasm TAS 8224247
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with ARR3: view

Pathways for ARR3 Gene

genes like me logo Genes that share pathways with ARR3: view

Pathways by source for ARR3 Gene

Gene Ontology (GO) - Biological Process for ARR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001932 regulation of protein phosphorylation IEA --
GO:0006897 endocytosis IEA --
GO:0007165 signal transduction IEA --
GO:0007601 visual perception IEA --
genes like me logo Genes that share ontologies with ARR3: view

Compounds for ARR3 Gene

(4) Novoseek inferred chemical compound relationships for ARR3 Gene

Compound -log(P) Hits PubMed IDs
calcium 42.3 28
threonine 8.91 1
retinoic acid 7.31 3
arachidonic acid 5.7 1
genes like me logo Genes that share compounds with ARR3: view

Transcripts for ARR3 Gene

Unigene Clusters for ARR3 Gene

Arrestin 3, retinal (X-arrestin):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARR3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: -
SP2: - -
SP3:
SP4:

Relevant External Links for ARR3 Gene

GeneLoc Exon Structure for
ARR3
ECgene alternative splicing isoforms for
ARR3

Expression for ARR3 Gene

mRNA expression in normal human tissues for ARR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARR3 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (4.8) and Colon - Transverse (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ARR3 Gene

SOURCE GeneReport for Unigene cluster for ARR3 Gene Hs.308

mRNA Expression by UniProt/SwissProt for ARR3 Gene

P36575-ARRC_HUMAN
Tissue specificity: Inner and outer segments, and the inner plexiform regions of the retina
genes like me logo Genes that share expressions with ARR3: view

Orthologs for ARR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARR3 36
  • 99.66 (n)
  • 99.74 (a)
ARR3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARR3 36
  • 88.14 (n)
  • 84.54 (a)
ARR3 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARR3 36
  • 88.14 (n)
  • 86.34 (a)
ARR3 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arr3 36
  • 85.65 (n)
  • 83.69 (a)
Arr3 16
Arr3 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARR3 37
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARR3 37
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arr3 36
  • 85.47 (n)
  • 83.42 (a)
chicken
(Gallus gallus)
Aves ARR3 36
  • 71.55 (n)
  • 70.16 (a)
ARR3 37
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARR3 37
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii arr3a 36
  • 64.18 (n)
  • 60.74 (a)
arr3a 37
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Arr1 37
  • 41 (a)
ManyToMany
Arr2 37
  • 35 (a)
ManyToMany
CG32683 37
  • 15 (a)
ManyToMany
krz 37
  • 39 (a)
ManyToMany
Arr2 38
  • 37 (a)
Arr1 38
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea arr-1 37
  • 41 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10346 37
  • 46 (a)
OneToMany
Species with no ortholog for ARR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARR3 Gene

ENSEMBL:
Gene Tree for ARR3 (if available)
TreeFam:
Gene Tree for ARR3 (if available)

Paralogs for ARR3 Gene

Paralogs for ARR3 Gene

Selected SIMAP similar genes for ARR3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARR3: view

Variants for ARR3 Gene

Sequence variations from dbSNP and Humsavar for ARR3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs946451 -- 70,266,764(-) AATGA(C/T)TAGTG upstream-variant-2KB
rs1199473 -- 70,270,712(+) GGCTG(C/T)CATTT intron-variant
rs1401168 -- 70,273,049(-) AATGC(A/G)CTAAT intron-variant
rs1416568 -- 70,272,958(-) GAATG(A/G)ATAAC intron-variant
rs1572732 -- 70,276,378(-) AATAC(A/G)AAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARR3 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
nsv525258 CNV Gain 19592680

Relevant External Links for ARR3 Gene

HapMap Linkage Disequilibrium report
ARR3

Disorders for ARR3 Gene

(2) Novoseek inferred disease relationships for ARR3 Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 31.7 5
tumors 4.5 1
genes like me logo Genes that share disorders with ARR3: view

No data available for UniProtKB/Swiss-Prot for ARR3 Gene

Publications for ARR3 Gene

  1. X-arrestin: a new retinal arrestin mapping to the X chromosome. (PMID: 8224247) Murakami A. … Inana G. (FEBS Lett. 1993) 2 3 4 23
  2. Cone arrestin identified by targeting expression of a functional family. (PMID: 8308033) Craft C.M. … Wiechmann A.F. (J. Biol. Chem. 1994) 3 4 23
  3. Immunolocalization of X-arrestin in human cone photoreceptors. (PMID: 8612728) Sakuma H. … McLaren M.J. (FEBS Lett. 1996) 3 4 23
  4. Isolation and characterization of the human X-arrestin gene. (PMID: 9931451) Sakuma H. … Inana G. (Gene 1998) 3 4 23
  5. Loss of cone molecular markers in rhodopsin-mutant human retinas with retinitis pigmentosa. (PMID: 11063754) John S.K. … Milam A.H. (Mol. Vis. 2000) 3 23

Products for ARR3 Gene

Sources for ARR3 Gene

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