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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARPP21 Gene

protein-coding   GIFtS: 51
GCID: GC03P035680

CAMP-Regulated Phosphoprotein, 21kDa

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CAMP-Regulated Phosphoprotein, 21kDa1 2     R3HDM32
R3H Domain Containing 31 2     RCS2
Thymocyte CAMP-Regulated Phosphoprotein2 3     CAMP-Regulated Phosphoprotein 212
ARPP-212 3     Cyclic AMP-Regulated Phosphoprotein, 21 KD2
TARPP2 3     

External Ids:    HGNC: 169681   Entrez Gene: 107772   Ensembl: ENSG000001729957   OMIM: 6054885   UniProtKB: Q9UBL03   

Export aliases for ARPP21 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARPP21 Gene:
This gene encodes a cAMP-regulated phosphoprotein. The encoded protein is enriched in the caudate nucleus and
cerebellar cortex. A similar protein in mouse may be involved in regulating the effects of dopamine in the basal
ganglia. Alternate splicing results in multiple transcript variants. (provided by RefSeq, Jun 2012)

GeneCards Summary for ARPP21 Gene: 
ARPP21 (cAMP-regulated phosphoprotein, 21kDa) is a protein-coding gene. Diseases associated with ARPP21 include periapical periodontitis, and kidney cancer. GO annotations related to this gene include calmodulin binding and molecular_function. An important paralog of this gene is R3HDM2.

UniProtKB/Swiss-Prot: ARP21_HUMAN, Q9UBL0
Function: Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in
neurons (By similarity)

Gene Wiki entry for ARPP21 (ARPP-21) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ARPP21
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ARPP21 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARPP21

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARPP21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.3   Ensembl cytogenetic band:  3p22.3   HGNC cytogenetic band: 3p24.3

ARPP21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARPP21 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P035680:  view genomic region     (about GC identifiers)

Start:
35,680,437 bp from pter      End:
35,835,988 bp from pter
Size:
155,552 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARP21_HUMAN, Q9UBL0 (See protein sequence)
Recommended Name: cAMP-regulated phosphoprotein 21  
Size: 812 amino acids; 89196 Da
Subunit: Interacts with CALM1 (By similarity)
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: B4DG96 Q49AK3 Q49AS6 Q4G0V4 Q6NYC3 Q86V31 Q9UF93
Alternative splicing: 6 isoforms:  Q9UBL0-1   Q9UBL0-2   Q9UBL0-3   Q9UBL0-4   Q9UBL0-5   Q9UBL0-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARPP21: NX_Q9UBL0

Explore proteomics data for ARPP21 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation at Ser-56 favors interaction with CALM1 (By similarity)
  • UniProtKB: Isoform 1 is methylated by CARM1 in immature thymocytes (Probable)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UBL0

  • ARPP21 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARPP21 Protein Expression
    REFSEQ proteins (8 alternative transcripts): 
    NP_001020239.1  NP_001020240.1  NP_001254545.1  NP_001254546.1  NP_001254547.1  NP_001254548.1  NP_057384.2  NP_938409.1  

    ENSEMBL proteins: 
     ENSP00000411644   ENSP00000412411   ENSP00000398598   ENSP00000405276   ENSP00000409808  
     ENSP00000187397   ENSP00000396324   ENSP00000409331   ENSP00000415134   ENSP00000413005  
     ENSP00000401602   ENSP00000417838   ENSP00000390151   ENSP00000379742   ENSP00000389754  
     ENSP00000412341   ENSP00000390169   ENSP00000412326   ENSP00000379741   ENSP00000406964  
     ENSP00000397720   ENSP00000410171   ENSP00000399482   ENSP00000408271   ENSP00000396116  
     ENSP00000412233   ENSP00000414351   ENSP00000337792  

    Human Recombinant Protein Products for ARPP21: 
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    OriGene Protein Over-expression Lysate for ARPP21
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    Novus Biologicals ARPP21 Lysates
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ARPP21 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005737cytoplasm IEA--

    ARPP21 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for ARPP21 
    Cloud-Clone Corp. CLIAs for ARPP21


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001374 R3H_ss-bd
     IPR024771 SUZ

    Graphical View of Domain Structure for InterPro Entry Q9UBL0

    ProtoNet protein and cluster: Q9UBL0

    UniProtKB/Swiss-Prot: ARP21_HUMAN, Q9UBL0
    Similarity: Contains 1 R3H domain
    Similarity: Contains 1 SUZ domain


    ARPP21 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARP21_HUMAN, Q9UBL0
    Function: Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in
    neurons (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003676nucleic acid binding IEA--
    GO:0005516calmodulin binding IEA--
         
    ARPP21 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Arpp21):
     nervous system 

    ARPP21 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Arpp21tm1Lex for ARPP21

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ARPP21 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ARPP21

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    miRNA
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    hsa-miR-194* hsa-miR-548k hsa-miR-15a hsa-miR-128 hsa-miR-502-3p hsa-miR-877* hsa-miR-183* hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): ARPP21 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARPP21


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARPP21

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5 Interacting proteins for ARPP21 (Q9UBL03 ENSP000001873974) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583I2D: score=3 
    CALM2P621583I2D: score=3 
    CALM3P621583I2D: score=3 
    TERF1ENSP000002766034STRING: ENSP00000276603
    TERF2IPENSP000003000864STRING: ENSP00000300086
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0034605cellular response to heat IEA--

    ARPP21 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARPP21 (ARP21)

    Search CenterWatch for drugs/clinical trials and news about ARPP21 / ARP21

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARPP21 gene (8 alternative transcripts): 
    NM_001025068.1  NM_001025069.1  NM_001267616.1  NM_001267617.1  NM_001267618.1  NM_001267619.1  NM_016300.4  NM_198399.1  

    Unigene Cluster for ARPP21:

    CAMP-regulated phosphoprotein, 21kDa
    Hs.475902  [show with all ESTs]
    Unigene Representative Sequence: NM_001267616
    18/37 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 37):
    ENST00000450234 ENST00000428373(uc003cfz.3) ENST00000421492 ENST00000444190(uc003cga.3 uc011axy.2 uc003cgf.3 uc003cgg.3)
    ENST00000449196 ENST00000187397(uc003cgb.3) ENST00000452563 ENST00000438577
    ENST00000414496 ENST00000419330 ENST00000427542 ENST00000474696 ENST00000412048(uc003cgc.3 uc003cgd.3 uc011axx.2)
    ENST00000396482 ENST00000432682 ENST00000432450 ENST00000413378 ENST00000417925


    miRNA
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    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate ARPP21 (see all 36):
    hsa-miR-194* hsa-miR-548k hsa-miR-15a hsa-miR-128 hsa-miR-502-3p hsa-miR-877* hsa-miR-183* hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): ARPP21 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARPP21

    Additional mRNA sequence: 

    AF112220.1 AK055064.1 AK057559.1 AK289649.1 AK289868.1 AK294484.1 AL133109.1 BC017805.1 
    BC031106.1 BC036399.1 BC041385.1 BC051828.1 BC066651.1 

    24/26 DOTS entries (see all 26):

    DT.100018569  DT.120925919  DT.91657204  DT.444005  DT.75100497  DT.91749854  DT.101972307  DT.455208 
    DT.92419856  DT.99931705  DT.100813480  DT.120925878  DT.120925908  DT.120925859  DT.120925870  DT.120925951 
    DT.95207814  DT.105934  DT.120925928  DT.97835534  DT.100749419  DT.86844264  DT.92424608  DT.97809076 

    24/131 AceView cDNA sequences (see all 131):

    BG185183 BC051828 BG196103 AA984183 NM_016300 BX092571 AA425364 H44077 
    BU181069 AI651350 AK093648 AL119615 BG219525 AF112220 AA425570 BG200683 
    AA426561 BX094489 N46772 BC066651 AX748241 BG220012 AI269073 BU741999 

    GeneLoc Exon Structure

    5/32 Alternative Splicing Database (ASD) splice patterns (SP) for ARPP21 (see all 32)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b · 16c · 16d ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:              -     -     -     -     -     -     -     -     -     -           -     -     -     -     -                 -                             -   
    SP5:                    -     -     -     -     -     -     -     -     -           -     -     -     -     -                 -                             -   

    ExUns: 17a · 17b · 17c · 17d · 17e ^ 18a · 18b · 18c · 18d · 18e ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b · 27c ^ 28a · 28b · 28c ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                  -     -           -                                       
    SP3:                                                                                                  -     -           -                                       
    SP4:                                                                                                                                                            
    SP5:  -     -     -     -     -                                                                                                                                 

    ExUns: 29a · 29b · 29c ^ 30a · 30b ^ 31a · 31b ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36a · 36b · 36c
    SP1:                                                        -     -                           
    SP2:                                                                                          
    SP3:                                                                                          
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for ARPP21

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARPP21 expression in normal human tissues (normalized intensities)      ARPP21 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTTACCAC
    ARPP21 Expression
    About this image


    ARPP21 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 28 entries
             Thalamus
             Olfactory Bulb   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 8 entries
             Mononuclear Myocytes Hyoid Arch Muscles
             cavities and their linings/intraembryonic coelom/diaphragm   
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Telencephalon
             brain/midbrain/lateral wall   
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Autopod
             limb/hindlimb/hind-paw   
     
     Thymus (Hematopoietic System)    fully expand to see all 3 entries
             Double Negative 3 Thymocytes Thymus
             Thymus

    See ARPP21 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARPP21

    SOURCE GeneReport for Unigene cluster: Hs.475902

    UniProtKB/Swiss-Prot: ARP21_HUMAN, Q9UBL0
    Tissue specificity: Isoform 2 is expressed in brain. Isoform 1 is present in immature thymocytes (at protein
    level)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ARPP21 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arpp211 , 5 cyclic AMP-regulated phosphoprotein, 211, 5 86.49(n)1
    87.24(a)1
      9 (62.46 cM)5
    741001  NM_033264.21  NP_150289.11 
     1120650915 
    chicken
    (Gallus gallus)
    Aves ARPP211 cAMP-regulated phosphoprotein, 21kDa 80.11(n)
    82.62(a)
      428459  XM_426019.3  XP_426019.2 
    lizard
    (Anolis carolinensis)
    Reptilia ARPP216
    cAMP-regulated phosphoprotein, 21kDa
    73(a)
    1 ↔ 1
    6(42606196-42783108)
    zebrafish
    (Danio rerio)
    Actinopterygii arpp216
    cyclic AMP-regulated phosphoprotein, 21
    33(a)
    1 ↔ 1
    19(44489208-44520022)
    fruit fly
    (Drosophila melanogaster)
    Insecta enc6
    encore
    7(a)
    1 → many
    3L(3818679-3842326)
    worm
    (Caenorhabditis elegans)
    Secernentea ZK121.26
    Protein ZK121.2
    20(a)
    1 → many
    III(5341690-5344273)


    ENSEMBL Gene Tree for ARPP21 (if available)
    TreeFam Gene Tree for ARPP21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARPP21 gene
    R3HDM22  R3HDM12  
    4 SIMAP similar genes for ARPP21 using alignment to 14 protein entries:     ARP21_HUMAN (see all proteins):
    ARPP-21    R3HDM    R3HDM1    R3HDM2

    ARPP21 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2762 SNPs in ARPP21 are shown (see all 2762)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1420363111,2
    C--35678763(+) CTTTG-/AAAAAA 1 -- us2k10--------
    rs76352851,2
    A--35678819(+) GTTTGA/TCAATA 1 -- us2k10--------
    rs76133351,2
    A--35678852(+) TGTTTC/TGTTCT 1 -- us2k10--------
    rs76249591,2
    A--35678857(+) CGTTCC/TTTCAC 1 -- us2k10--------
    rs76135081,2
    A--35678867(+) CATAGG/TCACTG 1 -- us2k10--------
    rs1874247611,2
    --35678869(+) TAGGCA/CCTGGA 1 -- us2k10--------
    rs1454241821,2
    C--35678875(+) CTGGAA/GTATGT 1 -- us2k10--------
    rs76353631,2
    A,H--35678877(+) GGAGTA/GTGTAC 1 -- us2k14Minor allele frequency- G:0.00NS EA 398
    rs76353851,2
    A--35678931(+) TATAGA/GACTGG 1 -- us2k10--------
    rs1155886711,2
    F--35678946(+) CATTTA/TAAAAA 1 -- us2k11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for ARPP21 (35680437 - 35835988 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ARPP21:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv267712CNV Insertion20981092
    esv269187CNV Insertion20981092
    nsv876691CNV Loss21882294
    nsv876690CNV Loss21882294
    nsv526191CNV Loss19592680
    nsv526436CNV Loss19592680
    dgv599n27CNV Gain19166990
    esv2752002CNV Gain17911159
    nsv516510CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605488    OMIM disorders: --

    6 diseases for ARPP21:    About MalaCards
    periapical periodontitis    kidney cancer    tuberous sclerosis    periodontitis
    alzheimer's disease    neuronitis

    1 disease from the University of Copenhagen DISEASES database for ARPP21:
    Tuberous sclerosis

    ARPP21 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): ARPP21
    Human Genome Epidemiology (HuGE) Navigator: ARPP21 (0 documents)

    Export disorders for ARPP21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARPP21 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with ARPP21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue. (PubMed id 8120638)1, 2, 3 Brene S.... Persson H. (1994)
    2. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    6. Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    8. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PubMed id 21116278)1 Furney S.J....Lovestone S. (2010)
    9. A genome-wide study of common SNPs and CNVs in cognit ive performance in the CANTAB. (PubMed id 19734545)1 Need A.C....Goldstein D.B. (2009)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10777 HGNC: 16968 AceView: ARPP-21 Ensembl:ENSG00000172995 euGenes: HUgn10777
    ECgene: ARPP21 H-InvDB: ARPP21

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARPP21 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARPP21 gene:
    Search GeneIP for patents involving ARPP21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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