Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ARPP21 Gene

Aliases for ARPP21 Gene

  • CAMP-Regulated Phosphoprotein, 21kDa 2 3
  • Thymocyte CAMP-Regulated Phosphoprotein 3 4
  • R3H Domain Containing 3 2 3
  • ARPP-21 3 4
  • TARPP 3 4
  • Cyclic AMP-Regulated Phosphoprotein, 21 KD 3
  • CAMP-Regulated Phosphoprotein 21 3
  • R3HDM3 3
  • RCS 3

External Ids for ARPP21 Gene

Summaries for ARPP21 Gene

Entrez Gene Summary for ARPP21 Gene

  • This gene encodes a cAMP-regulated phosphoprotein. The encoded protein is enriched in the caudate nucleus and cerebellar cortex. A similar protein in mouse may be involved in regulating the effects of dopamine in the basal ganglia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

GeneCards Summary for ARPP21 Gene

ARPP21 (CAMP-Regulated Phosphoprotein, 21kDa) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and calmodulin binding. An important paralog of this gene is R3HDM1.

UniProtKB/Swiss-Prot for ARPP21 Gene

  • Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons.

Gene Wiki entry for ARPP21 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARPP21 Gene

Genomics for ARPP21 Gene

Genomic Location for ARPP21 Gene

Start:
35,638,945 bp from pter
End:
35,794,496 bp from pter
Size:
155,552 bases
Orientation:
Plus strand

Genomic View for ARPP21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARPP21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPP21 Gene

No data available for Regulatory Elements for ARPP21 Gene

Proteins for ARPP21 Gene

  • Protein details for ARPP21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBL0-ARP21_HUMAN
    Recommended name:
    cAMP-regulated phosphoprotein 21
    Protein Accession:
    Q9UBL0
    Secondary Accessions:
    • B4DG96
    • Q49AK3
    • Q49AS6
    • Q4G0V4
    • Q6NYC3
    • Q86V31
    • Q9UF93

    Protein attributes for ARPP21 Gene

    Size:
    812 amino acids
    Molecular mass:
    89196 Da
    Quaternary structure:
    • Interacts with CALM1.

    Alternative splice isoforms for ARPP21 Gene

neXtProt entry for ARPP21 Gene

Proteomics data for ARPP21 Gene at MOPED

Post-translational modifications for ARPP21 Gene

No data available for DME Specific Peptides for ARPP21 Gene

Domains for ARPP21 Gene

Protein Domains for ARPP21 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

ARP21_HUMAN
Domain:
  • Contains 1 R3H domain.:
    • Q9UBL0
  • Contains 1 SUZ domain.:
    • Q9UBL0
genes like me logo Genes that share domains with ARPP21: view

No data available for Gene Families for ARPP21 Gene

Function for ARPP21 Gene

Molecular function for ARPP21 Gene

UniProtKB/Swiss-Prot Function: Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons.

Gene Ontology (GO) - Molecular Function for ARPP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0005516 calmodulin binding IEA --
genes like me logo Genes that share ontologies with ARPP21: view

Phenotypes for ARPP21 Gene

MGI mutant phenotypes for ARPP21:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ARPP21: view

Animal Models for ARPP21 Gene

MGI Knock Outs for ARPP21:

miRNA for ARPP21 Gene

miRTarBase miRNAs that target ARPP21

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ARPP21 Gene

Localization for ARPP21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARPP21 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARPP21 Gene COMPARTMENTS Subcellular localization image for ARPP21 gene
Compartment Confidence
nucleus 3
cytosol 2
chloroplast 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ARPP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ARPP21: view

Pathways for ARPP21 Gene

SuperPathways for ARPP21 Gene

No Data Available

Interacting Proteins for ARPP21 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000187397%0d%0a9606.ENSP00000268379%0d%0a9606.ENSP00000203407%0d%0a9606.ENSP00000249269%0d%0a9606.ENSP00000276603%0d%0a9606.ENSP00000300086%0d%0a
Selected Interacting proteins: ENSP00000187397 Q9UBL0-ARP21_HUMAN for ARPP21 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for ARPP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0034605 cellular response to heat IEA --
genes like me logo Genes that share ontologies with ARPP21: view

No data available for Pathways by source for ARPP21 Gene

Transcripts for ARPP21 Gene

Unigene Clusters for ARPP21 Gene

CAMP-regulated phosphoprotein, 21kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARPP21 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b · 16c · 16d ^
SP1:
SP2:
SP3:
SP4: - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - -
SP10:
SP11: - - - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - -
SP13: - - - - -
SP14: - - - - - - -
SP15: - - - - -
SP16: - - -
SP17: - - - - - - - - - - - -
SP18: - - - - - - - - - - - - -
SP19: - -
SP20: - - - - - - - - - - - - - -
SP21: - - - - - - - - - - - - -
SP22: - -
SP23: -
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30: - - - - - - - - - -
SP31:
SP32:

ExUns: 17a · 17b · 17c · 17d · 17e ^ 18a · 18b · 18c · 18d · 18e ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b · 27c ^ 28a · 28b · 28c ^
SP1:
SP2: - - -
SP3: - - -
SP4:
SP5: - - - - -
SP6:
SP7:
SP8: - - - - -
SP9: - - - - - - - - - - -
SP10:
SP11: - - - - -
SP12:
SP13:
SP14: - - - - -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25: -
SP26:
SP27:
SP28:
SP29: - - -
SP30:
SP31:
SP32:

ExUns: 29a · 29b · 29c ^ 30a · 30b ^ 31a · 31b ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36a · 36b · 36c
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26: -
SP27: -
SP28:
SP29:
SP30:
SP31:
SP32:

Relevant External Links for ARPP21 Gene

GeneLoc Exon Structure for
ARPP21
ECgene alternative splicing isoforms for
ARPP21

Expression for ARPP21 Gene

mRNA expression in normal human tissues for ARPP21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARPP21 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (14.6), Brain - Putamen (basal ganglia) (11.7), and Brain - Caudate (basal ganglia) (11.5).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ARPP21 Gene

SOURCE GeneReport for Unigene cluster for ARPP21 Gene Hs.475902

mRNA Expression by UniProt/SwissProt for ARPP21 Gene

Q9UBL0-ARP21_HUMAN
Tissue specificity: Isoform 2 is expressed in brain. Isoform 1 is present in immature thymocytes (at protein level).
genes like me logo Genes that share expressions with ARPP21: view

Orthologs for ARPP21 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARPP21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARPP21 36
  • 99.59 (n)
  • 99.75 (a)
ARPP21 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARPP21 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARPP21 36
  • 91.65 (n)
  • 93.7 (a)
ARPP21 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arpp21 36
  • 86.37 (n)
  • 87.24 (a)
Arpp21 16
Arpp21 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARPP21 37
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARPP21 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arpp21 36
  • 86.67 (n)
  • 87.5 (a)
chicken
(Gallus gallus)
Aves ARPP21 36
  • 80.6 (n)
  • 82.46 (a)
ARPP21 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARPP21 37
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii arpp21 37
  • 40 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta enc 37
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZK121.2 37
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 21 (a)
OneToMany
Species with no ortholog for ARPP21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARPP21 Gene

ENSEMBL:
Gene Tree for ARPP21 (if available)
TreeFam:
Gene Tree for ARPP21 (if available)

Paralogs for ARPP21 Gene

Paralogs for ARPP21 Gene

genes like me logo Genes that share paralogs with ARPP21: view

Variants for ARPP21 Gene

Sequence variations from dbSNP and Humsavar for ARPP21 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs3092 -- 35,642,677(-) TTAGG(A/G)ATTTG intron-variant
rs3302 -- 35,685,733(-) AAATA(A/G)TATAA utr-variant-3-prime, intron-variant
rs875524 -- 35,738,675(+) ACCAT(C/T)ATCAC intron-variant
rs876159 -- 35,739,242(-) AGACA(A/C)AGGAC intron-variant
rs895736 -- 35,658,553(-) ATTGC(A/G)TATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARPP21 Gene

Variant ID Type Subtype PubMed ID
nsv876690 CNV Loss 21882294
nsv876691 CNV Loss 21882294
nsv526191 CNV Loss 19592680
esv267712 CNV Insertion 20981092
nsv526436 CNV Loss 19592680
nsv516510 CNV Gain 19592680
esv2752002 CNV Gain 17911159
dgv599n27 CNV Gain 19166990
esv269187 CNV Insertion 20981092

Relevant External Links for ARPP21 Gene

HapMap Linkage Disequilibrium report
ARPP21

Disorders for ARPP21 Gene

(1) University of Copenhagen DISEASES for ARPP21 Gene

Relevant External Links for ARPP21

Genetic Association Database (GAD)
ARPP21
Human Genome Epidemiology (HuGE) Navigator
ARPP21
genes like me logo Genes that share disorders with ARPP21: view

No data available for UniProtKB/Swiss-Prot for ARPP21 Gene

Publications for ARPP21 Gene

  1. Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue. (PMID: 8120638) Brene S. … Persson H. (J. Neurosci. 1994) 2 3 4
  2. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PMID: 15144186) Brill L.M. … Peters E.C. (Anal. Chem. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ARPP21 Gene

Sources for ARPP21 Gene

Back to Top

Content