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Aliases for ARPP21 Gene

Aliases for ARPP21 Gene

  • CAMP Regulated Phosphoprotein 21 2 3 5
  • Thymocyte CAMP-Regulated Phosphoprotein 3 4
  • R3H Domain Containing 3 2 3
  • ARPP-21 3 4
  • TARPP 3 4
  • Cyclic AMP-Regulated Phosphoprotein, 21 KD 3
  • CAMP-Regulated Phosphoprotein, 21kDa 2
  • CAMP Regulated Phosphoprotein 21kDa 3
  • CAMP-Regulated Phosphoprotein 21 3
  • R3HDM3 3
  • RCS 3

External Ids for ARPP21 Gene

Summaries for ARPP21 Gene

Entrez Gene Summary for ARPP21 Gene

  • This gene encodes a cAMP-regulated phosphoprotein. The encoded protein is enriched in the caudate nucleus and cerebellar cortex. A similar protein in mouse may be involved in regulating the effects of dopamine in the basal ganglia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

GeneCards Summary for ARPP21 Gene

ARPP21 (CAMP Regulated Phosphoprotein 21) is a Protein Coding gene. Diseases associated with ARPP21 include Suppurative Periapical Periodontitis. GO annotations related to this gene include nucleic acid binding and calmodulin binding. An important paralog of this gene is R3HDM1.

UniProtKB/Swiss-Prot for ARPP21 Gene

  • Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons.

Gene Wiki entry for ARPP21 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARPP21 Gene

Genomics for ARPP21 Gene

Regulatory Elements for ARPP21 Gene

Enhancers for ARPP21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G035662 1.4 FANTOM5 Ensembl ENCODE dbSUPER 34 +26.0 26038 5.2 JUND POLR2A SMARCA4 FOXP2 HNF4A FOS ARPP21 ARPP21-AS1 GC03P035745
GH03G035659 0.9 FANTOM5 dbSUPER 22 +21.0 20976 0.7 CTCF PKNOX1 SMC3 HNF4A ZBTB33 RAD21 ARPP21 ARPP21-AS1 GC03P035745
GH03G035676 0.9 Ensembl ENCODE dbSUPER 21.4 +39.9 39914 3.8 POLR2A SMARCA4 ARPP21 ARPP21-AS1 MIR128-2 GC03P035745
GH03G035674 0.6 dbSUPER 21.8 +36.5 36522 2.1 JUND CREB1 MAX HNF4A RAD21 YY1 ARPP21 ARPP21-AS1 GC03P035745
GH03G035668 0.6 dbSUPER 21.7 +32.5 32543 5.0 CTCF POLR2A SMARCA4 HNF4A MNT EP300 RAD21 ARPP21 ARPP21-AS1 GC03P035745
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARPP21 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARPP21 Gene

Chromosome:
3
Start:
35,638,945 bp from pter
End:
35,794,496 bp from pter
Size:
155,552 bases
Orientation:
Plus strand

Genomic View for ARPP21 Gene

Genes around ARPP21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARPP21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARPP21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPP21 Gene

Proteins for ARPP21 Gene

  • Protein details for ARPP21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBL0-ARP21_HUMAN
    Recommended name:
    cAMP-regulated phosphoprotein 21
    Protein Accession:
    Q9UBL0
    Secondary Accessions:
    • B4DG96
    • Q49AK3
    • Q49AS6
    • Q4G0V4
    • Q6NYC3
    • Q86V31
    • Q9UF93

    Protein attributes for ARPP21 Gene

    Size:
    812 amino acids
    Molecular mass:
    89196 Da
    Quaternary structure:
    • Interacts with CALM1.

    Alternative splice isoforms for ARPP21 Gene

neXtProt entry for ARPP21 Gene

Post-translational modifications for ARPP21 Gene

No data available for DME Specific Peptides for ARPP21 Gene

Domains & Families for ARPP21 Gene

Protein Domains for ARPP21 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ARPP21 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARPP21: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ARPP21 Gene

Function for ARPP21 Gene

Molecular function for ARPP21 Gene

UniProtKB/Swiss-Prot Function:
Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons.

Gene Ontology (GO) - Molecular Function for ARPP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0005516 calmodulin binding IEA --
genes like me logo Genes that share ontologies with ARPP21: view
genes like me logo Genes that share phenotypes with ARPP21: view

Animal Models for ARPP21 Gene

MGI Knock Outs for ARPP21:

Animal Model Products

CRISPR Products

miRNA for ARPP21 Gene

miRTarBase miRNAs that target ARPP21

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARPP21 Gene

Localization for ARPP21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARPP21 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARPP21 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 1
extracellular 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ARPP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ARPP21: view

Pathways & Interactions for ARPP21 Gene

SuperPathways for ARPP21 Gene

No Data Available

Interacting Proteins for ARPP21 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000187397%0d%0a9606.ENSP00000268379%0d%0a9606.ENSP00000265350%0d%0a9606.ENSP00000314343%0d%0a9606.ENSP00000292035%0d%0a9606.ENSP00000263205%0d%0a
Selected Interacting proteins: Q9UBL0-ARP21_HUMAN ENSP00000187397 for ARPP21 Gene via IID STRING

Gene Ontology (GO) - Biological Process for ARPP21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0034605 cellular response to heat IEA --
genes like me logo Genes that share ontologies with ARPP21: view

No data available for Pathways by source and SIGNOR curated interactions for ARPP21 Gene

Drugs & Compounds for ARPP21 Gene

No Compound Related Data Available

Transcripts for ARPP21 Gene

Unigene Clusters for ARPP21 Gene

CAMP-regulated phosphoprotein, 21kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARPP21 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b · 16c · 16d ^
SP1:
SP2:
SP3:
SP4: - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - -
SP10:
SP11: - - - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - -
SP13: - - - - -
SP14: - - - - - - -
SP15: - - - - -
SP16: - - -
SP17: - - - - - - - - - - - -
SP18: - - - - - - - - - - - - -
SP19: - -
SP20: - - - - - - - - - - - - - -
SP21: - - - - - - - - - - - - -
SP22: - -
SP23: -
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30: - - - - - - - - - -
SP31:
SP32:

ExUns: 17a · 17b · 17c · 17d · 17e ^ 18a · 18b · 18c · 18d · 18e ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b · 27c ^ 28a · 28b · 28c ^
SP1:
SP2: - - -
SP3: - - -
SP4:
SP5: - - - - -
SP6:
SP7:
SP8: - - - - -
SP9: - - - - - - - - - - -
SP10:
SP11: - - - - -
SP12:
SP13:
SP14: - - - - -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25: -
SP26:
SP27:
SP28:
SP29: - - -
SP30:
SP31:
SP32:

ExUns: 29a · 29b · 29c ^ 30a · 30b ^ 31a · 31b ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36a · 36b · 36c
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26: -
SP27: -
SP28:
SP29:
SP30:
SP31:
SP32:

Relevant External Links for ARPP21 Gene

GeneLoc Exon Structure for
ARPP21
ECgene alternative splicing isoforms for
ARPP21

Expression for ARPP21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARPP21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARPP21 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x14.6), Brain - Putamen (basal ganglia) (x11.7), and Brain - Caudate (basal ganglia) (x11.5).

Protein differential expression in normal tissues from HIPED for ARPP21 Gene

This gene is overexpressed in Neutrophil (49.9), Fetal Brain (12.1), and Adipocyte (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARPP21 Gene



NURSA nuclear receptor signaling pathways regulating expression of ARPP21 Gene:

ARPP21

SOURCE GeneReport for Unigene cluster for ARPP21 Gene:

Hs.475902

mRNA Expression by UniProt/SwissProt for ARPP21 Gene:

Q9UBL0-ARP21_HUMAN
Tissue specificity: Isoform 2 is expressed in brain. Isoform 1 is present in immature thymocytes (at protein level).

Evidence on tissue expression from TISSUES for ARPP21 Gene

  • Nervous system(5)
  • Lung(4.3)
  • Kidney(4.2)
  • Muscle(2.5)
genes like me logo Genes that share expression patterns with ARPP21: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARPP21 Gene

Orthologs for ARPP21 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARPP21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARPP21 35 34
  • 99.59 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ARPP21 35 34
  • 91.65 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ARPP21 35
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arpp21 34
  • 86.67 (n)
mouse
(Mus musculus)
Mammalia Arpp21 16 35 34
  • 86.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ARPP21 35
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARPP21 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARPP21 34 35
  • 80.6 (n)
lizard
(Anolis carolinensis)
Reptilia ARPP21 35
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii arpp21 35
  • 40 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta enc 35
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZK121.2 35
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 21 (a)
OneToMany
Species where no ortholog for ARPP21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARPP21 Gene

ENSEMBL:
Gene Tree for ARPP21 (if available)
TreeFam:
Gene Tree for ARPP21 (if available)

Paralogs for ARPP21 Gene

Paralogs for ARPP21 Gene

genes like me logo Genes that share paralogs with ARPP21: view

Variants for ARPP21 Gene

Sequence variations from dbSNP and Humsavar for ARPP21 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs193920911 Uncertain significance 35,729,432(+) GAATG(G/T)AATAG reference, missense
rs1000002310 -- 35,725,769(+) CTAGC(C/T)ACTTG intron-variant
rs1000052628 -- 35,683,504(+) TTTTT(A/T)AATTT intron-variant
rs1000063886 -- 35,650,132(+) TTTGA(C/T)ACCGT intron-variant
rs1000082330 -- 35,656,259(+) ATATA(A/G)TAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARPP21 Gene

Variant ID Type Subtype PubMed ID
dgv1367e212 CNV gain 25503493
dgv4717n100 CNV gain 25217958
dgv599n27 CNV gain 19166990
dgv8281n54 CNV gain 21841781
esv2752002 CNV gain 17911159
esv2763724 CNV gain 21179565
esv3303433 CNV mobile element insertion 20981092
esv3304909 CNV mobile element insertion 20981092
esv3348964 CNV insertion 20981092
esv3377520 CNV insertion 20981092
esv3383183 CNV insertion 20981092
esv3595840 CNV gain 21293372
esv3893681 CNV loss 25118596
nsv1139105 CNV deletion 24896259
nsv516510 CNV gain 19592680
nsv526191 CNV loss 19592680
nsv526436 CNV loss 19592680
nsv590055 CNV gain 21841781
nsv590060 CNV gain 21841781

Variation tolerance for ARPP21 Gene

Residual Variation Intolerance Score: 20.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.01; 74.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARPP21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARPP21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARPP21 Gene

Disorders for ARPP21 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARPP21 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
suppurative periapical periodontitis
  • apical abscess
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ARPP21

Genetic Association Database (GAD)
ARPP21
Human Genome Epidemiology (HuGE) Navigator
ARPP21
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARPP21
genes like me logo Genes that share disorders with ARPP21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARPP21 Gene

Publications for ARPP21 Gene

  1. Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue. (PMID: 8120638) Brene S. … Persson H. (J. Neurosci. 1994) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PMID: 15144186) Brill L.M. … Peters E.C. (Anal. Chem. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 64

Products for ARPP21 Gene

Sources for ARPP21 Gene

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