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Aliases for ARPP19 Gene

Aliases for ARPP19 Gene

  • CAMP-Regulated Phosphoprotein, 19kDa 2 3
  • ARPP-19 3 4
  • ARPP16 3 6
  • CAMP-Regulated Phosphoprotein 19 3
  • Cyclic AMP Phosphoprotein, 19 KD 3
  • Endosulfine Alpha-Like 2
  • ARPP-16 3
  • ENSAL 3

External Ids for ARPP19 Gene

Previous GeneCards Identifiers for ARPP19 Gene

  • GC15M050627
  • GC15M052839
  • GC15M029670

Summaries for ARPP19 Gene

Entrez Gene Summary for ARPP19 Gene

  • The 19-kD cAMP-regulated phosphoprotein plays a role in regulating mitosis by inhibiting protein phosphatase-2A (PP2A; see MIM 176915) (summary by Gharbi-Ayachi et al., 2010 [PubMed 21164014]).[supplied by OMIM, Feb 2011]

GeneCards Summary for ARPP19 Gene

ARPP19 (CAMP-Regulated Phosphoprotein, 19kDa) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include receptor binding and potassium channel regulator activity. An important paralog of this gene is ENSA.

UniProtKB/Swiss-Prot for ARPP19 Gene

  • Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression.

Gene Wiki entry for ARPP19 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARPP19 Gene

Genomics for ARPP19 Gene

Regulatory Elements for ARPP19 Gene

Genomic Location for ARPP19 Gene

Start:
52,547,045 bp from pter
End:
52,569,883 bp from pter
Size:
22,839 bases
Orientation:
Minus strand

Genomic View for ARPP19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARPP19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPP19 Gene

Proteins for ARPP19 Gene

  • Protein details for ARPP19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56211-ARP19_HUMAN
    Recommended name:
    cAMP-regulated phosphoprotein 19
    Protein Accession:
    P56211
    Secondary Accessions:
    • B2R497
    • Q6IAM2
    • Q86TA6
    • Q9UD70

    Protein attributes for ARPP19 Gene

    Size:
    112 amino acids
    Molecular mass:
    12323 Da
    Quaternary structure:
    • Interacts (when phosphorylated at Ser-62) with PPP2R2D (By similarity). Interacts with SNCA.

    Alternative splice isoforms for ARPP19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARPP19 Gene

Proteomics data for ARPP19 Gene at MOPED

Post-translational modifications for ARPP19 Gene

  • Isoform ARPP-16 contains a N-acetylmethionine at position 1.
  • Phosphorylation at Ser-62 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A (By similarity). Phosphorylated by PKA.
  • Ubiquitination at Lys58 and Lys69
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARPP19 Gene

Domains for ARPP19 Gene

Protein Domains for ARPP19 Gene

Suggested Antigen Peptide Sequences for ARPP19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56211

UniProtKB/Swiss-Prot:

ARP19_HUMAN :
  • P56211
Family:
  • Belongs to the endosulfine family.
genes like me logo Genes that share domains with ARPP19: view

No data available for Gene Families for ARPP19 Gene

Function for ARPP19 Gene

Molecular function for ARPP19 Gene

UniProtKB/Swiss-Prot Function: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression.
UniProtKB/Swiss-Prot Induction: Expression may be regulated by miR-451.

Gene Ontology (GO) - Molecular Function for ARPP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004864 protein phosphatase inhibitor activity IEA --
GO:0005102 receptor binding IDA 9653196
GO:0008601 protein phosphatase type 2A regulator activity ISS --
GO:0015459 potassium channel regulator activity IDA 9653196
GO:0019212 phosphatase inhibitor activity ISS --
genes like me logo Genes that share ontologies with ARPP19: view

Phenotypes for ARPP19 Gene

GenomeRNAi human phenotypes for ARPP19:
genes like me logo Genes that share phenotypes with ARPP19: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARPP19

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARPP19 Gene

Localization for ARPP19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARPP19 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARPP19 Gene COMPARTMENTS Subcellular localization image for ARPP19 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ARPP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ARPP19: view

Pathways for ARPP19 Gene

genes like me logo Genes that share pathways with ARPP19: view

Pathways by source for ARPP19 Gene

1 Cell Signaling Technology pathway for ARPP19 Gene

Interacting Proteins for ARPP19 Gene

Gene Ontology (GO) - Biological Process for ARPP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IMP 21164014
GO:0000278 mitotic cell cycle TAS --
GO:0007067 mitotic nuclear division IMP 21164014
GO:0007212 dopamine receptor signaling pathway IEA --
GO:0034047 regulation of protein phosphatase type 2A activity ISS --
genes like me logo Genes that share ontologies with ARPP19: view

Transcripts for ARPP19 Gene

Unigene Clusters for ARPP19 Gene

CAMP-regulated phosphoprotein, 19kDa:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARPP19

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARPP19 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h · 6i
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - -
SP7: - - - - - -
SP8: - - - - - -
SP9: - - -
SP10: - -
SP11:

Relevant External Links for ARPP19 Gene

GeneLoc Exon Structure for
ARPP19
ECgene alternative splicing isoforms for
ARPP19

Expression for ARPP19 Gene

mRNA expression in normal human tissues for ARPP19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARPP19 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (5.0), Brain - Caudate (basal ganglia) (4.4), and Brain - Nucleus accumbens (basal ganglia) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ARPP19 Gene

SOURCE GeneReport for Unigene cluster for ARPP19 Gene Hs.512908

genes like me logo Genes that share expressions with ARPP19: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ARPP19 Gene

Orthologs for ARPP19 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARPP19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARPP19 35
  • 98.81 (n)
  • 100 (a)
ARPP19 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARPP19 35
  • 95.83 (n)
  • 99.11 (a)
ARPP19 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARPP19 35
  • 95.54 (n)
  • 100 (a)
ARPP19 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arpp19 35
  • 91.07 (n)
  • 99.11 (a)
Arpp19 16
Arpp19 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARPP19 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARPP19 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arpp19 35
  • 91.67 (n)
  • 99.11 (a)
chicken
(Gallus gallus)
Aves ARPP19 35
  • 85.42 (n)
  • 97.32 (a)
ARPP19 36
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Arpp19 35
tropical clawed frog
(Silurana tropicalis)
Amphibia arpp19 35
  • 77.88 (n)
  • 88.18 (a)
Str.1289 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2840 35
zebrafish
(Danio rerio)
Actinopterygii arpp19a 35
  • 71.11 (n)
  • 77.14 (a)
arpp19a 36
  • 74 (a)
OneToMany
arpp19b 36
  • 82 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta endos 36
  • 45 (a)
OneToMany
Species with no ortholog for ARPP19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARPP19 Gene

ENSEMBL:
Gene Tree for ARPP19 (if available)
TreeFam:
Gene Tree for ARPP19 (if available)

Paralogs for ARPP19 Gene

Paralogs for ARPP19 Gene

Selected SIMAP similar genes for ARPP19 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ARPP19 Gene

genes like me logo Genes that share paralogs with ARPP19: view

Variants for ARPP19 Gene

Sequence variations from dbSNP and Humsavar for ARPP19 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs3478 -- 52,551,245(+) ACAGT(C/T)AATGC utr-variant-3-prime
rs874815 -- 52,558,781(+) tcata(C/T)attaa intron-variant
rs1055746 -- 52,551,073(-) AAGAG(G/T)AGTTT utr-variant-3-prime
rs1055747 -- 52,550,864(-) AACTT(C/T)TTAAA utr-variant-3-prime
rs1061827 -- 52,547,485(-) AGTTG(A/G)AAAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ARPP19 Gene

Variant ID Type Subtype PubMed ID
nsv471245 CNV Gain 18288195
nsv833006 CNV Gain 17160897
esv1001541 CNV Gain 20482838

Relevant External Links for ARPP19 Gene

HapMap Linkage Disequilibrium report
ARPP19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARPP19 Gene

Disorders for ARPP19 Gene

No disorders were found for ARPP19 Gene.

No data available for UniProtKB/Swiss-Prot for ARPP19 Gene

Publications for ARPP19 Gene

  1. Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue. (PMID: 8120638) Brene S. … Persson H. (J. Neurosci. 1994) 3 4
  2. Alpha endosulfine is a novel molecule, structurally related to a family of phosphoproteins. (PMID: 8687439) Peyrollier K. … Bataille D. (Biochem. Biophys. Res. Commun. 1996) 2 3
  3. Human alpha-endosulfine, a possible regulator of sulfonylurea- sensitive K(ATP) channel: molecular cloning, expression and biological properties. (PMID: 9653196) Heron L. … Bataille D. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4
  4. Identification of okadaic-acid-induced genes by mRNA differential display in glioma cells. (PMID: 10754390) Chin L.S. … Murray S.F. (J. Biomed. Sci. 2000) 3 4
  5. ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated phosphoproteins. (PMID: 11279279) Dulubova I. … Nairn A.C. (J. Neurochem. 2001) 2 3

Products for ARPP19 Gene

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