Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ARPP19 Gene

protein-coding   GIFtS: 53
GCID: GC15M052839

CAMP-Regulated Phosphoprotein, 19kDa

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
CAMP-Regulated Phosphoprotein, 19kDa1 2     ARPP-162
ARPP-192 3     ENSAL2
ARPP162 5     CAMP-Regulated Phosphoprotein 192
Endosulfine Alpha-Like1     Cyclic AMP Phosphoprotein, 19 KD2

External Ids:    HGNC: 169671   Entrez Gene: 107762   Ensembl: ENSG000001289897   OMIM: 6054875   UniProtKB: P562113   

Export aliases for ARPP19 gene to outside databases

Previous GC identifers: GC15M050627 GC15M029670


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ARPP19 Gene:
The 19-kD cAMP-regulated phosphoprotein plays a role in regulating mitosis by inhibiting protein phosphatase-2A
(PP2A; see MIM 176915) (summary by Gharbi-Ayachi et al., 2010 (PubMed 21164014)).(supplied by OMIM, Feb 2011)

GeneCards Summary for ARPP19 Gene:
ARPP19 (cAMP-regulated phosphoprotein, 19kDa) is a protein-coding gene. GO annotations related to this gene include potassium channel regulator activity and receptor binding. An important paralog of this gene is ENSA.

UniProtKB/Swiss-Prot: ARP19_HUMAN, P56211
Function: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.
When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its
activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M
phase. May indirectly enhance GAP-43 expression

Gene Wiki entry for ARPP19 (ARPP-19) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARPP19 gene promoter:
         Sox5   AML1a   Cdc5   HNF-1A   Evi-1   FOXL1   POU2F1   HNF-1   POU2F1a   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ARPP19 promoter sequence
   Search Chromatin IP Primers for ARPP19

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARPP19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.2   Ensembl cytogenetic band:  15q21.2   HGNC cytogenetic band: 15q11.2

ARPP19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARPP19 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M052839:  view genomic region     (about GC identifiers)

Start:
52,839,242 bp from pter      End:
52,862,080 bp from pter
Size:
22,839 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ARP19_HUMAN, P56211 (See protein sequence)
Recommended Name: cAMP-regulated phosphoprotein 19  
Size: 112 amino acids; 12323 Da
Subunit: Interacts (when phosphorylated at Ser-62) with PPP2R2D (By similarity). Interacts with SNCA
Secondary accessions: B2R497 Q6IAM2 Q86TA6 Q9UD70
Alternative splicing: 2 isoforms:  P56211-1   P56211-2   (Contains a N-acetylmethionine at position 1 (By similarity))

Explore the universe of human proteins at neXtProt for ARPP19: NX_P56211

Explore proteomics data for ARPP19 at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-62 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and
    subsequent inactivation of PP2A (By similarity). Phosphorylated by PKA1
  • Isoform ARPP-16 contains a N-acetylmethionine at position 1 (By similarity)1
  • Ubiquitination2 at Lys58, Lys69
  • Modification sites at PhosphoSitePlus

  • See ARPP19 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006619.1  
    ENSEMBL proteins: 
     ENSP00000455625   ENSP00000249822   ENSP00000454234   ENSP00000457805   ENSP00000455986  
     ENSP00000455151   ENSP00000455610   ENSP00000454297   ENSP00000454612   ENSP00000457631  
     ENSP00000454341   ENSP00000457123  
    Reactome Protein details: P56211

    ARPP19 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ARPP19
    OriGene Protein Over-expression Lysate for ARPP19
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ARPP19
    GenScript Custom Purified and Recombinant Proteins Services for ARPP19
    Novus Biologicals ARPP19 Proteins
    Novus Biologicals ARPP19 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ARPP19

     
    Search eBioscience for Proteins for ARPP19 

    ARPP19 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for ARPP19  (ARPP-19)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ARPP19
    Novus Biologicals ARPP19 Antibody
    Search for Antibodies for ARPP19 at Abcam
    Cloud-Clone Corp. Antibodies for ARPP19
    Search ThermoFisher Antibodies for ARPP19
    Search LSBio for Antibodies for ARPP19

    ARPP19 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ARPP19
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ARPP19
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ARPP19
    Cloud-Clone Corp. CLIAs for ARPP19
    Search eBioscience for ELISAs for ARPP19 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR006760 Endosulphine

    Graphical View of Domain Structure for InterPro Entry P56211

    ProtoNet protein and cluster: P56211

    1 Blocks protein domain: IPB006760 cAMP-regulated phosphoprotein/endosulfine conserved region

    UniProtKB/Swiss-Prot: ARP19_HUMAN, P56211
    Similarity: Belongs to the endosulfine family


    Find genes that share domains with ARPP19           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARP19_HUMAN, P56211
    Function: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.
    When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its
    activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M
    phase. May indirectly enhance GAP-43 expression
    Induction: Expression may be regulated by miR-451

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004864protein phosphatase inhibitor activity IEA--
    GO:0005102receptor binding IDA9653196
    GO:0008601protein phosphatase type 2A regulator activity ISS--
    GO:0015459potassium channel regulator activity IDA9653196
    GO:0019212phosphatase inhibitor activity ISS--
         
    Find genes that share ontologies with ARPP19           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ARPP19:
     Increased cell number in G1, a 

         1 MGI phenotypic allele for Arpp19 (no phenotypes)

    Find genes that share phenotypes with ARPP19           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Arpp19tm1Lex for ARPP19

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARPP19
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARPP19

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARPP19
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARPP19

    miRNA
    Products:
        
    miRTarBase miRNAs that target ARPP19:
    hsa-mir-92a-3p (MIRT049208), hsa-mir-100-5p (MIRT048510), hsa-mir-320a (MIRT044725), hsa-mir-451a (MIRT016628), hsa-let-7b-5p (MIRT051971), hsa-mir-324-5p (MIRT043201)

    Block miRNA regulation of human, mouse, rat ARPP19 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARPP19 (see all 107):
    hsa-miR-4272 hsa-miR-15a hsa-miR-1304 hsa-miR-3116 hsa-miR-92b hsa-miR-490-5p hsa-miR-4324 hsa-miR-34c-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ARPP19
    Predesigned siRNA for gene silencing in human, mouse, rat ARPP19

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ARPP19

    Clone
    Products:
         
    OriGene clones in human, mouse for ARPP19 (see all 6)
    OriGene ORF clones in mouse, rat for ARPP19
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARPP19 (NM_006628)
    Sino Biological Human cDNA Clone for ARPP19
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARPP19
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARPP19

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ARPP19
    Browse ESI BIO Cell Lines and PureStem Progenitors for ARPP19 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARPP19


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ARP19_HUMAN, P56211: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with ARPP19           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ARPP19 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    2RNA Polymerase I Promoter Opening
    Mitotic Prophase0.56
    MASTL Facilitates Mitotic Progression0.00
    3Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32


    Find genes that share SuperPaths with ARPP19           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for ARPP19
        Cell Cycle / Checkpoint Control


    1 Reactome Pathway for ARPP19
        MASTL Facilitates Mitotic Progression


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARPP19
    Interactions:

        Search GeneGlobe Interaction Network for ARPP19

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARPP19 (P562113 ENSP000002498224) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IKBKGQ9Y6K93, ENSP000003586224I2D: score=1 STRING: ENSP00000358622
    PRKCGP051293I2D: score=2 
    DDX6ENSP000002640184STRING: ENSP00000264018
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    ANGEL2ENSP000003559294STRING: ENSP00000355929
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle IMP--
    GO:0000278mitotic cell cycle TAS--
    GO:0007067mitosis IMP--
    GO:0043086negative regulation of catalytic activity ISS--
    GO:0045722positive regulation of gluconeogenesis IDA9653196

    Find genes that share ontologies with ARPP19           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARPP19 (ARP19)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ARPP19 gene: 
    NM_006628.4  

    Unigene Cluster for ARPP19:

    CAMP-regulated phosphoprotein, 19kDa
    Hs.512908  [show with all ESTs]
    Unigene Representative Sequence: AL833077
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000566423(uc002ace.1) ENST00000249822(uc002acd.1) ENST00000561650
    ENST00000568196 ENST00000563277 ENST00000567669 ENST00000569723 ENST00000569281
    ENST00000564163 ENST00000563566 ENST00000561971 ENST00000565288 ENST00000567830

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ARPP19 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARPP19 (see all 107):
    hsa-miR-4272 hsa-miR-15a hsa-miR-1304 hsa-miR-3116 hsa-miR-92b hsa-miR-490-5p hsa-miR-4324 hsa-miR-34c-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ARPP19
    Predesigned siRNA for gene silencing in human, mouse, rat ARPP19
    Clone
    Products:
         
    OriGene clones in human, mouse for ARPP19 (see all 6)
    OriGene ORF clones in mouse, rat for ARPP19
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARPP19 (NM_006628)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARPP19
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARPP19
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ARPP19
    OriGene qSTAR qPCR primer pairs in human, mouse for ARPP19
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARPP19
      QuantiTect SYBR Green Assays in human, mouse, rat ARPP19
      QuantiFast Probe-based Assays in human, mouse, rat ARPP19

    Additional mRNA sequence: 

    AF084555.1 AJ223091.1 AK023195.1 AK123616.1 AK311751.1 AL833077.2 BC003418.1 BC100015.1 
    CR457132.1 

    Selected DOTS entries (see all 28):

    DT.100827137  DT.99985665  DT.92453292  DT.91834623  DT.92453299  DT.100827145  DT.100030805  DT.100722936 
    DT.100827134  DT.95164972  DT.121013627  DT.121013571  DT.97860182  DT.121013610  DT.121013626  DT.92453298 
    DT.100827139  DT.75103115  DT.91854733  DT.432747  DT.100827135  DT.100827138  DT.121013605  DT.121013616 

    Selected AceView cDNA sequences (see all 499):

    BQ226888 F08459 CR593448 AV715598 N70624 BP371605 AL707401 BU902230 
    BX331775 AA283769 BE697096 AI921243 CA450522 AJ714821 AK123616 BI548689 
    BP345218 CA306254 BE935959 CB150926 CB145794 AL135432 BC003418 BP347176 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARPP19 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h · 6i
    SP1:                                -     -           -           -                                                               
    SP2:                                -     -           -     -     -                                                               
    SP3:                                -     -           -     -     -                                                               
    SP4:                                -     -     -     -           -                                                               
    SP5:                                -     -           -     -     -                                                               


    ECgene alternative splicing isoforms for ARPP19

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ARPP19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCATTAACT
    ARPP19 Expression
    About this image


    ARPP19 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)
             Medulla Oblongata
    ARPP19 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARPP19 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.512908
        Custom PCR Arrays for ARPP19
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ARPP19
    OriGene qSTAR qPCR primer pairs in human, mouse for ARPP19
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARPP19
    QuantiTect SYBR Green Assays in human, mouse, rat ARPP19
    QuantiFast Probe-based Assays in human, mouse, rat ARPP19
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARPP19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ARPP19 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arpp191 , 5 cAMP-regulated phosphoprotein 191, 5 91.07(n)1
    99.11(a)1
      9 (42.25 cM)5
    590461  NM_001142655.11  NP_001136127.11 
     750376145 
    chicken
    (Gallus gallus)
    Aves ARPP191 cAMP-regulated phosphoprotein, 19kDa 85.42(n)
    97.32(a)
      768853  NM_001081707.1  NP_001075176.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Arpp192 similar to cyclic AMP phosphoprotein, 19 kD 77.85(n)    BC045060.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arpp19a1 cAMP-regulated phosphoprotein 19a 71.11(n)
    77.14(a)
      393603  NM_200630.1  NP_956924.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta endos6
    endosulfine
    45(a)
    1 → many
    3L(14022679-14024806)


    ENSEMBL Gene Tree for ARPP19 (if available)
    TreeFam Gene Tree for ARPP19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ARPP19 gene
    ENSA2  
    1 SIMAP similar gene for ARPP19 using alignment to 4 protein entries:     ARP19_HUMAN (see all proteins):
    ENSA

    Find genes that share paralogs with ARPP19           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for ARPP19
    PGOHUM00000240817 PGOHUM00000251404


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ARPP19 (see all 533)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs667785861,2
    C--32912654(-) TATTA-/TCTGTTT 1 -- int12Minor allele frequency- TC:0.25NA 4
    rs358845931,2
    C--32914368(+) TAAAA-/AC/C  
            
    ACAGT
    1 -- int10--------
    rs1883301191,2
    --52838961(+) ATGCAA/GGAGTC 1 -- ds50010--------
    rs757464871,2
    C,F--52838973(+) GTGGTG/AAGAAT 1 -- ds50011Minor allele frequency- A:0.02NA 120
    rs341972421,2
    C,F,H--52838988(+) ACTTCT/CGGCAA 1 -- ds500117Minor allele frequency- C:0.18NS EA NA 2224
    rs1401272491,2
    C--52838991(+) TCTGGA/CAATCA 1 -- ds50010--------
    rs1498123451,2
    --52839003(+) TCATTC/TAATCT 1 -- ds50010--------
    rs584357241,2
    C--52839295(+) AATGC-/AAAAAA 1 -- ds50011Minor allele frequency- A:0.00CSA 2
    rs596684471,2
    C--52839310(+) AAAAA-/A/AA  
            
    TCAAA
    1 -- ds50011NA 2
    rs31796581,2
    C--52839437(-) AATTTC/TTATTG 1 -- ut312Minor allele frequency- T:0.00NA 4

    HapMap Linkage Disequilibrium report for ARPP19 (52839242 - 52862080 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ARPP19:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1001541CNV Gain20482838
    nsv471245CNV Gain18288195
    nsv833006CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARPP19
    DNA2.0 Custom Variant and Variant Library Synthesis for ARPP19

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605487    OMIM disorders: --


    Find genes that share disorders with ARPP19           About GenesLikeMe


    Export disorders for ARPP19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ARPP19 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with ARPP19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A. (PubMed id 21164014)1, 2 Gharbi-Ayachi A.... Lorca T. (Science 2010)
    2. Conformation-specific binding of alpha-synuclein to novel protein partners detected by phage display and NMR spectroscopy. (PubMed id 17893145)1, 2 Woods W.S.... George J.M. (J. Biol. Chem. 2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated phosphoproteins. (PubMed id 11279279)1, 3 Dulubova I....Nairn A.C. (J. Neurochem. 2001)
    6. Identification of okadaic-acid-induced genes by mRNA differential display in glioma cells. (PubMed id 10754390)1, 2 Chin L.S.... Murray S.F. (J. Biomed. Sci. 2000)
    7. Human alpha-endosulfine, a possible regulator of sulfonylurea- sensitive K(ATP) channel: molecular cloning, expression and biological properties. (PubMed id 9653196)1, 2 Heron L.... Bataille D. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    8. Alpha endosulfine is a novel molecule, structurally related to a family of phosphoproteins. (PubMed id 8687439)1, 3 Peyrollier K....Bataille D. (Biochem. Biophys. Res. Commun. 1996)
    9. Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue. (PubMed id 8120638)1, 2 Brene S.... Persson H. (J. Neurosci. 1994)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10776 HGNC: 16967 AceView: ARPP-19 Ensembl:ENSG00000128989 euGenes: HUgn10776
    ECgene: ARPP19 H-InvDB: ARPP19

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ARPP19 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ARPP19 gene:
    Search GeneIP for patents involving ARPP19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ARPP19  
     OriGene qPCR primer pairs and template standards for ARPP19   OriGene Protein Over-expression Lysate for ARPP19  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ARPP19  
     OriGene qSTAR qPCR primer pairs in human, mouse for ARPP19   OriGene Purified Protein for ARPP19  
     OriGene ORF clones in mouse, rat for ARPP19   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ARPP19   OriGene Custom Protein Services for ARPP19  

     
     
     Block miRNA regulation of human, mouse, rat ARPP19 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ARPP19
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARPP19 Predesigned siRNA for gene silencing in human, mouse, rat ARPP19
     QuantiFast Probe-based Assays in human, mouse, rat ARPP19 QuantiTect SYBR Green Assays in human, mouse, rat ARPP19
     Custom PCR Arrays for ARPP19 Search Chromatin IP Primers for ARPP19
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARPP19  Search GeneGlobe Interaction Network for ARPP19
     Regulatory tfbs in ARPP19 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ARPP19 GenScript cDNA clones with any tag delivered in your preferred vector for ARPP19
     GenScript Custom Assay Services for ARPP19 GenScript Custom overexpressing Cell Line Services for ARPP19
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for ARPP19  (ARPP-19)

     Search Tocris compounds for ARPP19 (ARP19)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for ARPP19
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ARPP19 antibodies
     ARPP19 proteins
     ARPP19 lysates
     Search for Antibodies for ARPP19 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ARPP19
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ARPP19
     Antibodies for ARPP19
     ELISAs for ARPP19
     CLIAs for ARPP19



     Browse ESI BIO Cell Lines and PureStem Progenitors for ARPP19
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARPP19
     Browse SwitchGear 3'UTR luciferase reporter plasmids for ARPP19
     SwitchGear Promoter luciferase reporter plasmids for ARPP19
     Search ThermoFisher Antibodies for ARPP19
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARPP19
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARPP19
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARPP19
     Search LSBio for Antibodies for ARPP19
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for ARPP19
      Search eBioscience for proteins for ARPP19
      Search eBioscience for elisas for ARPP19
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ARPP19 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4