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Aliases for ARPP19 Gene

Aliases for ARPP19 Gene

  • CAMP Regulated Phosphoprotein 19 2 3 5
  • ARPP-19 3 4
  • CAMP-Regulated Phosphoprotein, 19kDa 2
  • CAMP-Regulated Phosphoprotein 19kDa 3
  • CAMP-Regulated Phosphoprotein 19 3
  • Cyclic AMP Phosphoprotein, 19 KD 3
  • Endosulfine Alpha-Like 2
  • ARPP-16 3
  • ARPP16 3
  • ENSAL 3

External Ids for ARPP19 Gene

Previous GeneCards Identifiers for ARPP19 Gene

  • GC15M050627
  • GC15M052839
  • GC15M029670

Summaries for ARPP19 Gene

Entrez Gene Summary for ARPP19 Gene

  • The 19-kD cAMP-regulated phosphoprotein plays a role in regulating mitosis by inhibiting protein phosphatase-2A (PP2A; see MIM 176915) (summary by Gharbi-Ayachi et al., 2010 [PubMed 21164014]).[supplied by OMIM, Feb 2011]

GeneCards Summary for ARPP19 Gene

ARPP19 (CAMP Regulated Phosphoprotein 19) is a Protein Coding gene. Among its related pathways are DNA Damage and Cell Cycle, Mitotic. GO annotations related to this gene include receptor binding and protein phosphatase inhibitor activity. An important paralog of this gene is ENSA.

UniProtKB/Swiss-Prot for ARPP19 Gene

  • Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression.

Gene Wiki entry for ARPP19 Gene

Additional gene information for ARPP19 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARPP19 Gene

Genomics for ARPP19 Gene

Regulatory Elements for ARPP19 Gene

Enhancers for ARPP19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H052565 1.1 ENCODE 42.8 +2.3 2336 4 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 ZBTB7B ARPP19 ENSG00000259935 MYO5A
GH15H052557 1.1 Ensembl ENCODE 42.3 +11.2 11201 3 PKNOX1 NFRKB BATF RAD21 CHAMP1 CBX5 FOS ATF7 RUNX3 IKZF2 ARPP19 MYO5A
GH15H052503 1.2 FANTOM5 Ensembl ENCODE 30.2 +65.1 65105 2 PKNOX1 JUNB BATF ZFHX2 EGR1 IKZF1 FOS IKZF2 CREM PRDM4 ARPP19 EEF1B2P1 GC15M057001
GH15H052480 1.6 FANTOM5 Ensembl ENCODE dbSUPER 19.3 +87.1 87110 4 SIX4 PKNOX1 TBL1XR1 JUN MAX BATF RFX5 POLR2A EED SMC3 ARPP19 MYO5A ENSG00000259709 MAPK6 EEF1B2P1 GC15M057001
GH15H052551 0.7 Ensembl ENCODE 42.4 +17.9 17883 1 POLR2A NR2F1 ARPP19 MYO5A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARPP19 on UCSC Golden Path with GeneCards custom track

Promoters for ARPP19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000076750 1583 2601 HDGF PKNOX1 MLX ARNT ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2

Genomic Location for ARPP19 Gene

Chromosome:
15
Start:
52,547,045 bp from pter
End:
52,569,883 bp from pter
Size:
22,839 bases
Orientation:
Minus strand

Genomic View for ARPP19 Gene

Genes around ARPP19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARPP19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARPP19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPP19 Gene

Proteins for ARPP19 Gene

  • Protein details for ARPP19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56211-ARP19_HUMAN
    Recommended name:
    cAMP-regulated phosphoprotein 19
    Protein Accession:
    P56211
    Secondary Accessions:
    • B2R497
    • Q6IAM2
    • Q86TA6
    • Q9UD70

    Protein attributes for ARPP19 Gene

    Size:
    112 amino acids
    Molecular mass:
    12323 Da
    Quaternary structure:
    • Interacts (when phosphorylated at Ser-62) with PPP2R2D (By similarity). Interacts with SNCA.

    Alternative splice isoforms for ARPP19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARPP19 Gene

Post-translational modifications for ARPP19 Gene

  • Phosphorylation at Ser-62 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A (By similarity). Phosphorylated by PKA.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARPP19 Gene

Domains & Families for ARPP19 Gene

Gene Families for ARPP19 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARPP19 Gene

Suggested Antigen Peptide Sequences for ARPP19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56211

UniProtKB/Swiss-Prot:

ARP19_HUMAN :
  • Belongs to the endosulfine family.
Family:
  • Belongs to the endosulfine family.
genes like me logo Genes that share domains with ARPP19: view

Function for ARPP19 Gene

Molecular function for ARPP19 Gene

UniProtKB/Swiss-Prot Function:
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression.
UniProtKB/Swiss-Prot Induction:
Expression may be regulated by miR-451.

Phenotypes From GWAS Catalog for ARPP19 Gene

Gene Ontology (GO) - Molecular Function for ARPP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004864 protein phosphatase inhibitor activity IBA,IEA --
GO:0005102 receptor binding IDA 9653196
GO:0015459 potassium channel regulator activity IDA 9653196
GO:0019212 phosphatase inhibitor activity ISS --
GO:0019888 protein phosphatase regulator activity ISS --
genes like me logo Genes that share ontologies with ARPP19: view
genes like me logo Genes that share phenotypes with ARPP19: view

Animal Model Products

CRISPR Products

miRNA for ARPP19 Gene

miRTarBase miRNAs that target ARPP19

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ARPP19
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARPP19 Gene

Localization for ARPP19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARPP19 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARPP19 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ARPP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IBA --
genes like me logo Genes that share ontologies with ARPP19: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ARPP19 Gene

Pathways & Interactions for ARPP19 Gene

genes like me logo Genes that share pathways with ARPP19: view

Pathways by source for ARPP19 Gene

1 Cell Signaling Technology pathway for ARPP19 Gene

Gene Ontology (GO) - Biological Process for ARPP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IMP 21164014
GO:0000278 mitotic cell cycle IMP 21164014
GO:0007049 cell cycle IEA --
GO:0007212 dopamine receptor signaling pathway IEA --
GO:0035308 negative regulation of protein dephosphorylation IBA --
genes like me logo Genes that share ontologies with ARPP19: view

No data available for SIGNOR curated interactions for ARPP19 Gene

Drugs & Compounds for ARPP19 Gene

No Compound Related Data Available

Transcripts for ARPP19 Gene

Unigene Clusters for ARPP19 Gene

CAMP-regulated phosphoprotein, 19kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ARPP19
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ARPP19 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h · 6i
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - -
SP7: - - - - - -
SP8: - - - - - -
SP9: - - -
SP10: - -
SP11:

Relevant External Links for ARPP19 Gene

GeneLoc Exon Structure for
ARPP19
ECgene alternative splicing isoforms for
ARPP19

Expression for ARPP19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARPP19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARPP19 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x5.0), Brain - Caudate (basal ganglia) (x4.4), and Brain - Nucleus accumbens (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for ARPP19 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.4) and Fetal Brain (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARPP19 Gene



Protein tissue co-expression partners for ARPP19 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARPP19 Gene:

ARPP19

SOURCE GeneReport for Unigene cluster for ARPP19 Gene:

Hs.512908

Evidence on tissue expression from TISSUES for ARPP19 Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with ARPP19: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARPP19 Gene

Orthologs for ARPP19 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARPP19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARPP19 33 34
  • 98.81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ARPP19 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARPP19 33 34
  • 95.83 (n)
dog
(Canis familiaris)
Mammalia ARPP19 33 34
  • 95.54 (n)
rat
(Rattus norvegicus)
Mammalia Arpp19 33
  • 91.67 (n)
mouse
(Mus musculus)
Mammalia Arpp19 33 16 34
  • 91.07 (n)
oppossum
(Monodelphis domestica)
Mammalia ARPP19 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARPP19 33 34
  • 85.42 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia arpp19 33
  • 77.88 (n)
Str.1289 33
African clawed frog
(Xenopus laevis)
Amphibia Arpp19 33
zebrafish
(Danio rerio)
Actinopterygii arpp19b 34
  • 82 (a)
OneToMany
arpp19a 33 34
  • 71.11 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2840 33
fruit fly
(Drosophila melanogaster)
Insecta endos 34
  • 45 (a)
OneToMany
Species where no ortholog for ARPP19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARPP19 Gene

ENSEMBL:
Gene Tree for ARPP19 (if available)
TreeFam:
Gene Tree for ARPP19 (if available)

Paralogs for ARPP19 Gene

Paralogs for ARPP19 Gene

(1) SIMAP similar genes for ARPP19 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ARPP19 Gene

genes like me logo Genes that share paralogs with ARPP19: view

Variants for ARPP19 Gene

Sequence variations from dbSNP and Humsavar for ARPP19 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000156086 -- 52,563,784(+) GACGA(A/T)TAACT intron-variant
rs1000253271 -- 52,547,312(+) AGCAT(C/T)AACTG utr-variant-3-prime
rs1000266096 -- 52,558,174(+) AGACT(A/G)GGCAC intron-variant
rs1000318232 -- 52,569,082(+) GGAGC(A/C)CGCCT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000438929 -- 52,563,625(+) GTCTA(G/T)TATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARPP19 Gene

Variant ID Type Subtype PubMed ID
esv1001541 CNV gain 20482838
esv3581707 CNV loss 25503493
esv3636488 CNV loss 21293372
nsv1047775 CNV gain 25217958
nsv471245 CNV gain 18288195
nsv833006 CNV gain 17160897

Variation tolerance for ARPP19 Gene

Residual Variation Intolerance Score: 45.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARPP19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARPP19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARPP19 Gene

Disorders for ARPP19 Gene

Relevant External Links for ARPP19

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARPP19

No disorders were found for ARPP19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARPP19 Gene

Publications for ARPP19 Gene

  1. The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A. (PMID: 21164014) Gharbi-Ayachi A … Lorca T (Science (New York, N.Y.) 2010) 3 4 60
  2. Conformation-specific binding of alpha-synuclein to novel protein partners detected by phage display and NMR spectroscopy. (PMID: 17893145) Woods WS … George JM (The Journal of biological chemistry 2007) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated phosphoproteins. (PMID: 11279279) Dulubova I … Nairn AC (Journal of neurochemistry 2001) 2 3 60

Products for ARPP19 Gene

Sources for ARPP19 Gene

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