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Aliases for ARPP19 Gene

Aliases for ARPP19 Gene

  • CAMP Regulated Phosphoprotein 19 2 3 5
  • ARPP-19 3 4
  • CAMP-Regulated Phosphoprotein, 19kDa 2
  • CAMP-Regulated Phosphoprotein 19kDa 3
  • CAMP-Regulated Phosphoprotein 19 3
  • Cyclic AMP Phosphoprotein, 19 KD 3
  • Endosulfine Alpha-Like 2
  • ARPP-16 3
  • ARPP16 3
  • ENSAL 3

External Ids for ARPP19 Gene

Previous GeneCards Identifiers for ARPP19 Gene

  • GC15M050627
  • GC15M052839
  • GC15M029670

Summaries for ARPP19 Gene

Entrez Gene Summary for ARPP19 Gene

  • The 19-kD cAMP-regulated phosphoprotein plays a role in regulating mitosis by inhibiting protein phosphatase-2A (PP2A; see MIM 176915) (summary by Gharbi-Ayachi et al., 2010 [PubMed 21164014]).[supplied by OMIM, Feb 2011]

GeneCards Summary for ARPP19 Gene

ARPP19 (CAMP Regulated Phosphoprotein 19) is a Protein Coding gene. Among its related pathways are Mitotic Prophase and Cell Cycle, Mitotic. GO annotations related to this gene include receptor binding and protein phosphatase inhibitor activity. An important paralog of this gene is ENSA.

UniProtKB/Swiss-Prot for ARPP19 Gene

  • Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression.

Gene Wiki entry for ARPP19 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARPP19 Gene

Genomics for ARPP19 Gene

Regulatory Elements for ARPP19 Gene

Enhancers for ARPP19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F052565 0.2 ENCODE 42.8 +2.3 2336 4.9 HDGF PKNOX1 CREB3L1 ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 YY1 ARPP19 MYO5A
GH15F052551 0.8 Ensembl ENCODE 42.4 +18.0 17983 1.8 ZNF146 ARPP19 MYO5A
GH15F052557 1.1 Ensembl ENCODE 42.3 +11.2 11201 3.2 HDAC1 PKNOX1 CBX3 CHAMP1 ZFHX2 PRDM10 TRIM24 ZSCAN29 ZNF600 FOS ARPP19 MYO5A
GH15F052503 1.3 FANTOM5 Ensembl ENCODE 30.2 +65.2 65216 2.5 PKNOX1 JUNB ZFHX2 RAD51 CBX5 IKZF1 TCF7 FOS CREM SPI1 ARPP19 EEF1B2P1 GC15M056102
GH15F052479 1.2 FANTOM5 Ensembl ENCODE 27.5 +87.5 87483 5.2 SIX4 TBP PKNOX1 MXI1 TBL1XR1 JUN MAX POLR2A NFYB EED ARPP19 MYO5A ENSG00000259709 MAPK6 EEF1B2P1 GC15M056102
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ARPP19 on UCSC Golden Path with GeneCards custom track

Promoters for ARPP19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000408117 1783 3001 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2

Genomic Location for ARPP19 Gene

Chromosome:
15
Start:
52,547,045 bp from pter
End:
52,569,883 bp from pter
Size:
22,839 bases
Orientation:
Minus strand

Genomic View for ARPP19 Gene

Genes around ARPP19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARPP19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARPP19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPP19 Gene

Proteins for ARPP19 Gene

  • Protein details for ARPP19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56211-ARP19_HUMAN
    Recommended name:
    cAMP-regulated phosphoprotein 19
    Protein Accession:
    P56211
    Secondary Accessions:
    • B2R497
    • Q6IAM2
    • Q86TA6
    • Q9UD70

    Protein attributes for ARPP19 Gene

    Size:
    112 amino acids
    Molecular mass:
    12323 Da
    Quaternary structure:
    • Interacts (when phosphorylated at Ser-62) with PPP2R2D (By similarity). Interacts with SNCA.

    Alternative splice isoforms for ARPP19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARPP19 Gene

Post-translational modifications for ARPP19 Gene

  • Isoform ARPP-16 contains a N-acetylmethionine at position 1.
  • Phosphorylation at Ser-62 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A (By similarity). Phosphorylated by PKA.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARPP19 Gene

Domains & Families for ARPP19 Gene

Protein Domains for ARPP19 Gene

Suggested Antigen Peptide Sequences for ARPP19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56211

UniProtKB/Swiss-Prot:

ARP19_HUMAN :
  • Belongs to the endosulfine family.
Family:
  • Belongs to the endosulfine family.
genes like me logo Genes that share domains with ARPP19: view

No data available for Gene Families for ARPP19 Gene

Function for ARPP19 Gene

Molecular function for ARPP19 Gene

UniProtKB/Swiss-Prot Function:
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression.
UniProtKB/Swiss-Prot Induction:
Expression may be regulated by miR-451.

Gene Ontology (GO) - Molecular Function for ARPP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004864 protein phosphatase inhibitor activity IEA,IBA --
GO:0005102 receptor binding IDA 9653196
GO:0015459 potassium channel regulator activity IDA 9653196
GO:0019212 phosphatase inhibitor activity ISS --
GO:0019888 protein phosphatase regulator activity ISS --
genes like me logo Genes that share ontologies with ARPP19: view
genes like me logo Genes that share phenotypes with ARPP19: view

Animal Model Products

miRNA for ARPP19 Gene

miRTarBase miRNAs that target ARPP19

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARPP19 Gene

Localization for ARPP19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARPP19 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARPP19 Gene COMPARTMENTS Subcellular localization image for ARPP19 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ARPP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IBA --
genes like me logo Genes that share ontologies with ARPP19: view

Pathways & Interactions for ARPP19 Gene

genes like me logo Genes that share pathways with ARPP19: view

Pathways by source for ARPP19 Gene

1 Cell Signaling Technology pathway for ARPP19 Gene

Gene Ontology (GO) - Biological Process for ARPP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IMP 21164014
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IMP 21164014
GO:0007212 dopamine receptor signaling pathway IEA --
GO:0034047 regulation of protein phosphatase type 2A activity IEA --
genes like me logo Genes that share ontologies with ARPP19: view

No data available for SIGNOR curated interactions for ARPP19 Gene

Transcripts for ARPP19 Gene

Unigene Clusters for ARPP19 Gene

CAMP-regulated phosphoprotein, 19kDa:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARPP19 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h · 6i
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - -
SP7: - - - - - -
SP8: - - - - - -
SP9: - - -
SP10: - -
SP11:

Relevant External Links for ARPP19 Gene

GeneLoc Exon Structure for
ARPP19
ECgene alternative splicing isoforms for
ARPP19

Expression for ARPP19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARPP19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARPP19 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x5.0), Brain - Caudate (basal ganglia) (x4.4), and Brain - Nucleus accumbens (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for ARPP19 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.4) and Fetal Brain (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARPP19 Gene



Protein tissue co-expression partners for ARPP19 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARPP19 Gene:

ARPP19

SOURCE GeneReport for Unigene cluster for ARPP19 Gene:

Hs.512908
genes like me logo Genes that share expression patterns with ARPP19: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ARPP19 Gene

Orthologs for ARPP19 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARPP19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARPP19 34 35
  • 98.81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ARPP19 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARPP19 34 35
  • 95.83 (n)
dog
(Canis familiaris)
Mammalia ARPP19 34 35
  • 95.54 (n)
rat
(Rattus norvegicus)
Mammalia Arpp19 34
  • 91.67 (n)
mouse
(Mus musculus)
Mammalia Arpp19 34 16 35
  • 91.07 (n)
oppossum
(Monodelphis domestica)
Mammalia ARPP19 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARPP19 34 35
  • 85.42 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia arpp19 34
  • 77.88 (n)
Str.1289 34
African clawed frog
(Xenopus laevis)
Amphibia Arpp19 34
zebrafish
(Danio rerio)
Actinopterygii arpp19b 35
  • 82 (a)
OneToMany
arpp19a 34 35
  • 71.11 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2840 34
fruit fly
(Drosophila melanogaster)
Insecta endos 35
  • 45 (a)
OneToMany
Species where no ortholog for ARPP19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARPP19 Gene

ENSEMBL:
Gene Tree for ARPP19 (if available)
TreeFam:
Gene Tree for ARPP19 (if available)

Paralogs for ARPP19 Gene

Paralogs for ARPP19 Gene

(1) SIMAP similar genes for ARPP19 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ARPP19 Gene

genes like me logo Genes that share paralogs with ARPP19: view

Variants for ARPP19 Gene

Sequence variations from dbSNP and Humsavar for ARPP19 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1055746 -- 52,551,073(-) AAGAG(G/T)AGTTT utr-variant-3-prime
rs1055747 -- 52,550,864(-) AACTT(C/T)TTAAA utr-variant-3-prime
rs10600080 -- 52,552,584(+) CTCAC(-/A)AAAAA intron-variant
rs1061827 -- 52,547,485(-) AGTTG(A/G)AAAAA utr-variant-3-prime
rs10709933 -- 52,562,885(+) AGAAG(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARPP19 Gene

Variant ID Type Subtype PubMed ID
esv1001541 CNV gain 20482838
esv3581707 CNV loss 25503493
esv3636488 CNV loss 21293372
nsv1047775 CNV gain 25217958
nsv471245 CNV gain 18288195
nsv833006 CNV gain 17160897

Variation tolerance for ARPP19 Gene

Residual Variation Intolerance Score: 45.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARPP19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARPP19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARPP19 Gene

Disorders for ARPP19 Gene

Relevant External Links for ARPP19

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARPP19

No disorders were found for ARPP19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARPP19 Gene

Publications for ARPP19 Gene

  1. The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A. (PMID: 21164014) Gharbi-Ayachi A. … Lorca T. (Science 2010) 3 4 64
  2. Conformation-specific binding of alpha-synuclein to novel protein partners detected by phage display and NMR spectroscopy. (PMID: 17893145) Woods W.S. … George J.M. (J. Biol. Chem. 2007) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated phosphoproteins. (PMID: 11279279) Dulubova I. … Nairn A.C. (J. Neurochem. 2001) 2 3 64

Products for ARPP19 Gene

Sources for ARPP19 Gene

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