Aliases for ARPIN Gene
External Ids for ARPIN Gene
Previous HGNC Symbols for ARPIN Gene
GeneCards Summary for ARPIN Gene
ARPIN (Actin Related Protein 2/3 Complex Inhibitor) is a Protein Coding gene. An important paralog of this gene is C15orf38-AP3S2.
UniProtKB/Swiss-Prot for ARPIN Gene
Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.