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Aliases for ARPIN Gene

Aliases for ARPIN Gene

  • Actin-Related Protein 2/3 Complex Inhibitor 2 3
  • Arp2/3 Inhibition Protein 3 4
  • C15orf38 3 4
  • Chromosome 15 Open Reading Frame 38 2
  • UPF0552 Protein C15orf38 3
  • C15orf38, 6
  • Arpin 3

External Ids for ARPIN Gene

Previous HGNC Symbols for ARPIN Gene

  • C15orf38

Summaries for ARPIN Gene

GeneCards Summary for ARPIN Gene

ARPIN (Actin-Related Protein 2/3 Complex Inhibitor) is a Protein Coding gene. An important paralog of this gene is C15orf38-AP3S2.

UniProtKB/Swiss-Prot for ARPIN Gene

  • Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARPIN Gene

Genomics for ARPIN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARPIN Gene

Start:
89,895,006 bp from pter
End:
89,912,990 bp from pter
Size:
17,985 bases
Orientation:
Minus strand

Genomic View for ARPIN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARPIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPIN Gene

No data available for Regulatory Elements for ARPIN Gene

Proteins for ARPIN Gene

  • Protein details for ARPIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6K5-ARPIN_HUMAN
    Recommended name:
    Arpin
    Protein Accession:
    Q7Z6K5
    Secondary Accessions:
    • E2QRD5

    Protein attributes for ARPIN Gene

    Size:
    226 amino acids
    Molecular mass:
    24943 Da
    Quaternary structure:
    • Associates with the Arp2/3 complex. Interacts with ARPC2; enhanced by activated RAC1. Interacts with ARPC5; the interaction is dependent on RAC1.

    Alternative splice isoforms for ARPIN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARPIN Gene

Proteomics data for ARPIN Gene at MOPED

Post-translational modifications for ARPIN Gene

  • Ubiquitination at Lys367
  • Modification sites at PhosphoSitePlus

Other Protein References for ARPIN Gene

No data available for DME Specific Peptides for ARPIN Gene

Domains for ARPIN Gene

Protein Domains for ARPIN Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q7Z6K5

UniProtKB/Swiss-Prot:

ARPIN_HUMAN :
  • Q7Z6K5
Domain:
  • The acidic C-terminus is necessary and sufficient to inhibit ARP2/3 complex activity.
Family:
  • Belongs to the Arpin family.
genes like me logo Genes that share domains with ARPIN: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for ARPIN Gene

Function for ARPIN Gene

Molecular function for ARPIN Gene

UniProtKB/Swiss-Prot Function: Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.

Gene Ontology (GO) - Molecular Function for ARPIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ARPIN: view

Phenotypes for ARPIN Gene

GenomeRNAi human phenotypes for ARPIN:
genes like me logo Genes that share phenotypes with ARPIN: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ARPIN Gene

Localization for ARPIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARPIN Gene

Cell projection, lamellipodium. Note=Colocalized with the WAVE complex at lamelliupodium tip. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for ARPIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030027 lamellipodium ISS --
genes like me logo Genes that share ontologies with ARPIN: view

No data available for Subcellular locations from COMPARTMENTS for ARPIN Gene

Pathways for ARPIN Gene

SuperPathways for ARPIN Gene

No Data Available

Interacting Proteins for ARPIN Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000350075%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000386394%0d%0a
Selected Interacting proteins: ENSP00000350075 Q7Z6K5-ARPIN_HUMAN for ARPIN Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for ARPIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030336 negative regulation of cell migration IMP 24132237
GO:0033058 directional locomotion IMP 24132237
GO:0051126 negative regulation of actin nucleation IDA 24132237
GO:2000393 negative regulation of lamellipodium morphogenesis IMP 24132237
genes like me logo Genes that share ontologies with ARPIN: view

No data available for Pathways by source for ARPIN Gene

Transcripts for ARPIN Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARPIN

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARPIN Gene

No ASD Table

Relevant External Links for ARPIN Gene

GeneLoc Exon Structure for
ARPIN
ECgene alternative splicing isoforms for
ARPIN

Expression for ARPIN Gene

mRNA expression in normal human tissues for ARPIN Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ARPIN Gene

genes like me logo Genes that share expressions with ARPIN: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARPIN Gene

Orthologs for ARPIN Gene

This gene was present in the common ancestor of chordates.

Orthologs for ARPIN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AP3S2 36
  • 56 (a)
OneToMany
LOC100170757 35
  • 98.97 (n)
  • 98.67 (a)
cow
(Bos Taurus)
Mammalia ARPIN 35
  • 88.35 (n)
  • 91.15 (a)
C21H15orf38 36
  • 91 (a)
OneToMany
dog
(Canis familiaris)
Mammalia C3H15orf38 35
  • 87.76 (n)
  • 87.61 (a)
C3H15orf38 36
  • 71 (a)
OneToMany
mouse
(Mus musculus)
Mammalia 2610034B18Rik 35
  • 84.51 (n)
  • 88.5 (a)
2610034B18Rik 36
  • 88 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
ManyToMany
-- 36
  • 73 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 72 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia RGD1311021 35
  • 85.4 (n)
  • 89.38 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c15orf38 35
  • 62.96 (n)
  • 64.89 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2502 35
zebrafish
(Danio rerio)
Actinopterygii C18H15orf38 36
  • 59 (a)
OneToMany
Dr.15865 35
zgc:112432 35
  • 59.29 (n)
  • 58.85 (a)
Species with no ortholog for ARPIN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARPIN Gene

ENSEMBL:
Gene Tree for ARPIN (if available)
TreeFam:
Gene Tree for ARPIN (if available)

Paralogs for ARPIN Gene

Paralogs for ARPIN Gene

Selected SIMAP similar genes for ARPIN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARPIN: view

Variants for ARPIN Gene

Relevant External Links for ARPIN Gene

HapMap Linkage Disequilibrium report
ARPIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for ARPIN Gene

Disorders for ARPIN Gene

No disorders were found for ARPIN Gene.

No data available for UniProtKB/Swiss-Prot for ARPIN Gene

Publications for ARPIN Gene

  1. Inhibitory signalling to the Arp2/3 complex steers cell migration. (PMID: 24132237) Dang I. … Gautreau A. (Nature 2013) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for ARPIN Gene

Sources for ARPIN Gene

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