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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARPC5L Gene

protein-coding   GIFtS: 51
GCID: GC09P127624

actin related protein 2/3 complex, subunit 5-like

 Explore 1 disease affiliated with
ARPC5L via our new
 Human Malady Compendium 
Biological research products
for ARPC5L
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Actin Related Protein 2/3 Complex, Subunit 5-Like1 2
ARC16-21 2 3
Arp2/3 Complex 16 KDa Subunit 22 3
MGC30381
Actin-Related Protein 2/3 Complex Subunit 5-Like Protein2

External Ids:    HGNC: 233661   Entrez Gene: 818732   Ensembl: ENSG000001369507   UniProtKB: Q9BPX53   

Export aliases for ARPC5L gene to outside databases

Previous GC identifers: GC09P123007 GC09P124703 GC09P126664 GC09P097243


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ARP5L_HUMAN, Q9BPX5
Function: May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and
together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARPC5L gene promoter:
         AML1a   Pax-2   Pax-2a   c-Ets-1   C/EBPalpha   GATA-2   PPAR-gamma1   Pax-2b   ZID   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARPC5L promoter sequence
   Search SABiosciences Chromatin IP Primers for ARPC5L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARPC5L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.3   Ensembl cytogenetic band:  9q33.3   HGNC cytogenetic band: 9q34.11

ARPC5L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARPC5L gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P127624:  view genomic region     (about GC identifiers)

Start:
127,624,409 bp from pter      End:
127,640,003 bp from pter
Size:
15,595 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ARP5L_HUMAN, Q9BPX5 (See protein sequence)
Recommended Name: Actin-related protein 2/3 complex subunit 5-like protein  
Size: 153 amino acids; 16941 Da
Subunit: May be a component of the Arp2/3 complex in which it may replace ARPC5
Subcellular location: Cytoplasm, cytoskeleton (By similarity)
Secondary accessions: Q7Z523

Explore the universe of human proteins at neXtProt for ARPC5L: NX_Q9BPX5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BPX5

  • ARPC5L Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_112240.1  
    ENSEMBL proteins: 
     ENSP00000345361   ENSP00000259477  

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    Uscn Proteins for ARPC5L

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--


    ARPC5L for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ARPC5L for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR006789 ARP2/3_p16_Arc

    Graphical View of Domain Structure for InterPro Entry Q9BPX5

    ProtoNet protein and cluster: Q9BPX5

    1 Blocks protein family: IPB006789 ARP2/3 complex 16 kDa subunit (p16-Arc)

    UniProtKB/Swiss-Prot: ARP5L_HUMAN, Q9BPX5
    Similarity: Belongs to the ARPC5 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ARP5L_HUMAN, Q9BPX5
    Function: May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and
    together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks

    miRNA
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    miRTarBase miRNAs that target ARPC5L:
    hsa-mir-335 (MIRT003229)

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    Inhib. RNA
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--


    ARPC5L for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ARPC5L:
     Synthetic lethal with Ras 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Pathogenic Escherichia coli infection
    Pathogenic Escherichia coli infection1.00
    Pathogenic Escherichia coli infection0.98
    2Shigellosis
    Shigellosis1.00
    3Fc gamma R-mediated phagocytosis
    Fc gamma R-mediated phagocytosis1.00
    4Bacterial invasion of epithelial cells
    Bacterial invasion of epithelial cells1.00
    5Regulation of Actin Cytoskeleton
    Regulation of actin cytoskeleton0.58

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for ARPC5L 
        Pathogenic Escherichia coli infection


    5         Kegg Pathways  (Kegg details for ARPC5L):
        Fc gamma R-mediated phagocytosis
    Regulation of actin cytoskeleton
    Bacterial invasion of epithelial cells
    Pathogenic Escherichia coli infection
    Shigellosis


    ARPC5L for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARPC5L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/28 Interacting proteins for ARPC5L (Q9BPX52, 3 ENSP000002594774) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TTLL3Q9Y4R72, 3MINT-65307 I2D: score=1 
    ACTR3BQ9P1U13, ENSP000002560014I2D: score=2 STRING: ENSP00000256001
    ARPC4P599983, ENSP000003804314I2D: score=4 STRING: ENSP00000380431
    ARRB2P321213I2D: score=1 
    ARPC1AENSP000002629424STRING: ENSP00000262942
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030833regulation of actin filament polymerization IEA--


    ARPC5L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARPC5L
    Search CenterWatch for drugs/clinical trials and news about ARPC5L / ARP5L 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARPC5L gene: 
    NM_030978.1  

    Unigene Cluster for ARPC5L:

    Actin related protein 2/3 complex, subunit 5-like
    Hs.132499  [show with all ESTs]
    Unigene Representative Sequence: BX537659
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000353214(uc004boz.1) ENST00000259477(uc004bpa.4) ENST00000465124


    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ARPC5L:
    hsa-miR-214 hsa-miR-761
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    Inhib. RNA
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    Additional cDNA sequence: 

    AF087842.1 AK023881.1 AK056174.1 AK308570.1 AK315604.1 BC000018.1 BC000798.1 BC002418.1 
    BC031388.1 BX537659.1 

    15 DOTS entries:

    DT.416875  DT.100819915  DT.100768563  DT.100743148  DT.65288492  DT.100819913  DT.95111382  DT.100027785 
    DT.121155942  DT.92433014  DT.121155894  DT.121155913  DT.91880829  DT.100819909  DT.40200342 

    24/320 AceView cDNA sequences (see all 320):

    CB321624 AK056174 T12577 AV650981 BU681496 AI820034 CR590465 BQ638847 
    AA933861 BM792380 BM973276 CR604261 AW405870 BE408017 AI433449 CR611360 
    BU740511 AV651487 BF593743 AI186765 AA652963 AU141352 BQ957120 CR616144 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ARPC5L (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b
    SP1:                          -     -     -     -                                 
    SP2:                                      -                                       
    SP3:        -     -     -     -     -     -     -     -                           
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for ARPC5L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARPC5L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATCTGCTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ARPC5L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARPC5L

    SOURCE GeneReport for Unigene cluster: Hs.132499
        SABiosciences Custom PCR Arrays for ARPC5L
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARPC5L gene from 9/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arpc5l1 , 5 actin related protein 2/3 complex, subunit 5-like1, 5 91.72(n)1
    96.73(a)1
      2 (24.42 cM)5
    741921  NM_028809.11  NP_083085.11 
     390080765 
    chicken
    (Gallus gallus)
    Aves F1P1S6_CHICK6
    Actin-related protein 2/3 complex subunit 5
    78(a)
    1 ↔ 1
    17(10302550-10305300)
    lizard
    (Anolis carolinensis)
    Reptilia ARPC5L6
    --
    86(a)
    1 ↔ 1
    GL344194.1(5842-9738)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX743620.12   -- 74.1(n)    BX743620.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc658812 hypothetical protein MGC65881 75.09(n)   393550  BC056697.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta p16-ARC6
    p16-ARC
    47(a)
    1 → many
    2L(2580291-2581114)
    worm
    (Caenorhabditis elegans)
    Secernentea arx-76
    C46H11.36
    ARp2/3 compleX component family member (arx-7)
    Probable actin-related protein 2/3 complex subunit...
    34(a)
    30(a)
    many ↔ many
    many ↔ many
    I(3069234-3070142)
    I(5041492-5042055)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CRK6
    AT5G652746
    ARP2/3 complex 16 kDa subunit (p16-Arc)
    32(a)
    30(a)
    many ↔ many
    many ↔ many
    4(735753-736604)
    5(26085300-26085960)
    rice
    (Oryza sativa)
    Liliopsida --
    actin polymerization factor, putative, expressed
    27(a)
    1 → many
    11(20263435-20265444)


    ENSEMBL Gene Tree for ARPC5L (if available)
    TreeFam Gene Tree for ARPC5L (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARPC5L gene
    ARPC52  
    1 SIMAP similar gene for ARPC5L using alignment to 1 protein entry:     ARP5L_HUMAN:
    ARPC5

    ARPC5L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/195 NCBI SNPs in ARPC5L are shown (see all 195    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1920633211,2
    --127629640(+) GTCTCA/GAATTC 1 -- us2k10--------
    rs1411273061,2
    C,--127629779(+) TTTCC-/CTCTCAA 1 -- us2k10--------
    rs1835735841,2
    --127629977(+) AATTTC/TTGCTG 1 -- us2k10--------
    rs772350401,2
    --127630029(+) TGGAAC/TTGTAT 1 -- us2k12Minor allele frequency- T:0.12CSA WA 120
    rs2010248691,2
    C--127630087(+) CTTTTC/TTTTTT 1 -- us2k10--------
    rs573435941,2
    C--127630088(+) TTTTT-/TGAGAC 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs2015803211,2
    --127630091(+) CTTTT-/CTTTTT 1 -- us2k10--------
    rs625833821,2
    --127630117(+) GAGTTC/TTGCTC 1 -- us2k10--------
    rs1866302731,2
    --127630323(+) CCTCAA/GGTGAT 1 -- us2k10--------
    rs1400697051,2
    --127630327(+) AGGTGA/TTCCGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARPC5L (127624409 - 127640003 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ARPC5L: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARPC5L
    DNA2.0 Custom Variant and Variant Library Synthesis for ARPC5L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ARPC5L for disorders           About GeneDecksing

    1 disease for ARPC5L:    About MalaCards
    shigellosis


    Export disorders for ARPC5L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARPC5L gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with ARPC5L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    2. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81873 HGNC: 23366 AceView: ARPC5L Ensembl:ENSG00000136950 euGenes: HUgn81873
    ECgene: ARPC5L Kegg: 81873 H-InvDB: ARPC5L

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARPC5L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARPC5L gene:
    Search GeneIP for patents involving ARPC5L

    GeneCards and IP:
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