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Aliases for ARPC5L Gene

Aliases for ARPC5L Gene

  • Actin Related Protein 2/3 Complex Subunit 5 Like 2 3 5
  • Arp2/3 Complex 16 KDa Subunit 2 3 4
  • ARC16-2 3 4
  • Actin-Related Protein 2/3 Complex Subunit 5-Like Protein 3
  • Actin Related Protein 2/3 Complex Subunit 5-Like 2

External Ids for ARPC5L Gene

Previous GeneCards Identifiers for ARPC5L Gene

  • GC09P123007
  • GC09P124703
  • GC09P126664
  • GC09P127624
  • GC09P097243

Summaries for ARPC5L Gene

GeneCards Summary for ARPC5L Gene

ARPC5L (Actin Related Protein 2/3 Complex Subunit 5 Like) is a Protein Coding gene. Among its related pathways are Development Slit-Robo signaling and Bacterial invasion of epithelial cells. GO annotations related to this gene include actin binding. An important paralog of this gene is ARPC5.

UniProtKB/Swiss-Prot for ARPC5L Gene

  • May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARPC5L Gene

Genomics for ARPC5L Gene

Regulatory Elements for ARPC5L Gene

Enhancers for ARPC5L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G124839 1.2 Ensembl ENCODE dbSUPER 23.9 -21.5 -21478 2.6 CTCF KLF1 KLF17 RAD21 ZFHX2 EGR1 SMC3 ZNF143 EGR2 ZBTB7A ARPC5L RPL35 GOLGA1 OLFML2A WDR38 PIR55692
GH09G124897 0.9 ENCODE 26.8 +35.8 35755 1.0 TBP FOXA2 RAD21 RARA CREM MIXL1 THAP11 CEBPB KAT8 MIER3 ARPC5L RPL35 WDR38 RPSAP76 RABEPK GOLGA1 GC09M124888 RNU4-82P GC09P124941
GH09G124860 1.4 ENCODE dbSUPER 15 -0.9 -873 6.5 PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZBTB7B SLC30A9 ZNF143 ZNF207 ARPC5L GOLGA1 RABEPK RPL35 WDR38
GH09G124866 1.4 ENCODE dbSUPER 14.2 +8.6 8586 8.0 HDGF PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 YBX1 ARPC5L NR6A1 ENSG00000236643 SCAI GC09M124888 RNU4-82P
GH09G124851 1.3 ENCODE dbSUPER 14.5 -9.2 -9197 2.5 PKNOX1 ATF1 CREB3L1 AGO1 ARID4B SIN3A ZNF2 ZNF48 ZBTB7B YY1 ARPC5L OLFML2A WDR38 PIR55692
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARPC5L on UCSC Golden Path with GeneCards custom track

Promoters for ARPC5L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000241360 -230 1801 PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZBTB7B SLC30A9 ZNF143 ZNF207

Genomic Location for ARPC5L Gene

Chromosome:
9
Start:
124,862,130 bp from pter
End:
124,877,733 bp from pter
Size:
15,604 bases
Orientation:
Plus strand

Genomic View for ARPC5L Gene

Genes around ARPC5L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARPC5L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARPC5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPC5L Gene

Proteins for ARPC5L Gene

  • Protein details for ARPC5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BPX5-ARP5L_HUMAN
    Recommended name:
    Actin-related protein 2/3 complex subunit 5-like protein
    Protein Accession:
    Q9BPX5
    Secondary Accessions:
    • Q7Z523

    Protein attributes for ARPC5L Gene

    Size:
    153 amino acids
    Molecular mass:
    16941 Da
    Quaternary structure:
    • May be a component of the Arp2/3 complex in which it may replace ARPC5.

neXtProt entry for ARPC5L Gene

Post-translational modifications for ARPC5L Gene

  • Ubiquitination at Lys69, Lys83, and Lys89
  • Modification sites at PhosphoSitePlus

Other Protein References for ARPC5L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARPC5L Gene

Domains & Families for ARPC5L Gene

Gene Families for ARPC5L Gene

Protein Domains for ARPC5L Gene

Suggested Antigen Peptide Sequences for ARPC5L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BPX5

UniProtKB/Swiss-Prot:

ARP5L_HUMAN :
  • Belongs to the ARPC5 family.
Family:
  • Belongs to the ARPC5 family.
genes like me logo Genes that share domains with ARPC5L: view

Function for ARPC5L Gene

Molecular function for ARPC5L Gene

UniProtKB/Swiss-Prot Function:
May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

Gene Ontology (GO) - Molecular Function for ARPC5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 16169070
GO:0051015 actin filament binding IBA --
genes like me logo Genes that share ontologies with ARPC5L: view

Phenotypes for ARPC5L Gene

MGI mutant phenotypes for ARPC5L:
inferred from 1 alleles
GenomeRNAi human phenotypes for ARPC5L:
genes like me logo Genes that share phenotypes with ARPC5L: view

Animal Models for ARPC5L Gene

MGI Knock Outs for ARPC5L:

Animal Model Products

CRISPR Products

miRNA for ARPC5L Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARPC5L Gene

Localization for ARPC5L Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARPC5L Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARPC5L gene
Compartment Confidence
extracellular 5
cytoskeleton 3
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ARPC5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA,IEA --
GO:0005856 cytoskeleton IEA --
GO:0005885 Arp2/3 protein complex IBA --
GO:0005925 focal adhesion IDA 21423176
GO:0015629 actin cytoskeleton IEA --
genes like me logo Genes that share ontologies with ARPC5L: view

Pathways & Interactions for ARPC5L Gene

genes like me logo Genes that share pathways with ARPC5L: view

Pathways by source for ARPC5L Gene

Gene Ontology (GO) - Biological Process for ARPC5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0016477 cell migration IBA --
GO:0030833 regulation of actin filament polymerization IEA --
GO:0034314 Arp2/3 complex-mediated actin nucleation IBA --
genes like me logo Genes that share ontologies with ARPC5L: view

No data available for SIGNOR curated interactions for ARPC5L Gene

Drugs & Compounds for ARPC5L Gene

No Compound Related Data Available

Transcripts for ARPC5L Gene

Unigene Clusters for ARPC5L Gene

Actin related protein 2/3 complex, subunit 5-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARPC5L Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b
SP1: - - - -
SP2: -
SP3: - - - - - - - -
SP4:
SP5:
SP6:

Relevant External Links for ARPC5L Gene

GeneLoc Exon Structure for
ARPC5L
ECgene alternative splicing isoforms for
ARPC5L

Expression for ARPC5L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARPC5L Gene

Protein differential expression in normal tissues from HIPED for ARPC5L Gene

This gene is overexpressed in Tlymphocyte (11.3) and NK cells (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARPC5L Gene



Protein tissue co-expression partners for ARPC5L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARPC5L Gene:

ARPC5L

SOURCE GeneReport for Unigene cluster for ARPC5L Gene:

Hs.132499

Evidence on tissue expression from TISSUES for ARPC5L Gene

  • Nervous system(4.5)
  • Liver(4.2)
  • Lung(2.7)
genes like me logo Genes that share expression patterns with ARPC5L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARPC5L Gene

Orthologs for ARPC5L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARPC5L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC739553 34
  • 100 (n)
ARPC5L 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARPC5L 35 34
  • 95.21 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ARPC5L 35 34
  • 93.9 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARPC5L 35
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arpc5l 34
  • 92.59 (n)
mouse
(Mus musculus)
Mammalia Arpc5l 16 35 34
  • 91.72 (n)
oppossum
(Monodelphis domestica)
Mammalia ARPC5L 35
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARPC5L 35
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARPC5L 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arpc5l 34
  • 74.34 (n)
zebrafish
(Danio rerio)
Actinopterygii arpc5la 34 35
  • 74 (n)
arpc5lb 35
  • 72 (a)
OneToMany
zgc65881 34
fruit fly
(Drosophila melanogaster)
Insecta p16-ARC 35
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea arx-7 35
  • 38 (a)
ManyToMany
C46H11.3 35
  • 32 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARC15 37
Species where no ortholog for ARPC5L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARPC5L Gene

ENSEMBL:
Gene Tree for ARPC5L (if available)
TreeFam:
Gene Tree for ARPC5L (if available)

Paralogs for ARPC5L Gene

Paralogs for ARPC5L Gene

(1) SIMAP similar genes for ARPC5L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARPC5L: view

Variants for ARPC5L Gene

Sequence variations from dbSNP and Humsavar for ARPC5L Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000070012 -- 124,876,698(+) GCTCT(C/T)GGGAC intron-variant, nc-transcript-variant
rs1000199376 -- 124,874,615(+) TGGGA(A/G)AGGCT intron-variant
rs1000368212 -- 124,868,841(+) TCTCC(C/T)GGGGG upstream-variant-2KB, utr-variant-5-prime
rs1000408117 -- 124,873,867(+) AGTGA(C/G)TTGGC intron-variant
rs1000527160 -- 124,871,304(+) ACCTC(A/G)GATAG intron-variant, nc-transcript-variant, utr-variant-5-prime

Variation tolerance for ARPC5L Gene

Residual Variation Intolerance Score: 45.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARPC5L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARPC5L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARPC5L Gene

Disorders for ARPC5L Gene

Relevant External Links for ARPC5L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARPC5L

No disorders were found for ARPC5L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARPC5L Gene

Publications for ARPC5L Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for ARPC5L Gene

Sources for ARPC5L Gene

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