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Aliases for ARPC5 Gene

Aliases for ARPC5 Gene

  • Actin Related Protein 2/3 Complex Subunit 5 2 3 5
  • Actin Related Protein 2/3 Complex Subunit 5, 16kDa 2 3
  • Arp2/3 Protein Complex Subunit P16 2 3
  • Arp2/3 Complex 16 KDa Subunit 3 4
  • P16-Arc 3 4
  • ARC16 3 4
  • Actin Related Protein 2/3 Complex, Subunit 5 (16 KD) 2
  • Actin Related Protein 2/3 Complex, Subunit 5, 16kDa 3
  • DJ127C7.3 3

External Ids for ARPC5 Gene

Previous GeneCards Identifiers for ARPC5 Gene

  • GC01M181121
  • GC01M179023
  • GC01M180112
  • GC01M180834
  • GC01M180326
  • GC01M181859
  • GC01M154832

Summaries for ARPC5 Gene

Entrez Gene Summary for ARPC5 Gene

  • This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for ARPC5 Gene

ARPC5 (Actin Related Protein 2/3 Complex Subunit 5) is a Protein Coding gene. Diseases associated with ARPC5 include lung squamous cell carcinoma. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include actin filament binding and structural constituent of cytoskeleton. An important paralog of this gene is ARPC5L.

UniProtKB/Swiss-Prot for ARPC5 Gene

  • Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

Gene Wiki entry for ARPC5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARPC5 Gene

Genomics for ARPC5 Gene

Regulatory Elements for ARPC5 Gene

Promoters for ARPC5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARPC5 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARPC5 Gene

Chromosome:
1
Start:
183,620,846 bp from pter
End:
183,635,941 bp from pter
Size:
15,096 bases
Orientation:
Minus strand

Genomic View for ARPC5 Gene

Genes around ARPC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARPC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARPC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPC5 Gene

Proteins for ARPC5 Gene

  • Protein details for ARPC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15511-ARPC5_HUMAN
    Recommended name:
    Actin-related protein 2/3 complex subunit 5
    Protein Accession:
    O15511
    Secondary Accessions:
    • A6NEC4
    • Q6PG42

    Protein attributes for ARPC5 Gene

    Size:
    151 amino acids
    Molecular mass:
    16320 Da
    Quaternary structure:
    • Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

    Alternative splice isoforms for ARPC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARPC5 Gene

Proteomics data for ARPC5 Gene at MOPED

Post-translational modifications for ARPC5 Gene

  • Polyubiquitinated by RNF128 with Lys-63-linked chains, leading to proteasomal degradation.
  • Ubiquitination at Lys 3, Lys 60, Lys 67, Lys 100, Lys 108, Lys 112, and Lys 131
  • Modification sites at PhosphoSitePlus

Other Protein References for ARPC5 Gene

Antibody Products

No data available for DME Specific Peptides for ARPC5 Gene

Domains & Families for ARPC5 Gene

Gene Families for ARPC5 Gene

Protein Domains for ARPC5 Gene

Suggested Antigen Peptide Sequences for ARPC5 Gene

Graphical View of Domain Structure for InterPro Entry

O15511

UniProtKB/Swiss-Prot:

ARPC5_HUMAN :
  • Belongs to the ARPC5 family.
Family:
  • Belongs to the ARPC5 family.
genes like me logo Genes that share domains with ARPC5: view

Function for ARPC5 Gene

Molecular function for ARPC5 Gene

UniProtKB/Swiss-Prot Function:
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

Gene Ontology (GO) - Molecular Function for ARPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051015 contributes_to actin filament binding IDA 11741539
genes like me logo Genes that share ontologies with ARPC5: view
genes like me logo Genes that share phenotypes with ARPC5: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARPC5 Gene

Localization for ARPC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARPC5 Gene

Cytoplasm, cytoskeleton. Cell projection.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARPC5 Gene COMPARTMENTS Subcellular localization image for ARPC5 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ARPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9359840
GO:0005885 Arp2/3 protein complex IEA,IDA 11741539
genes like me logo Genes that share ontologies with ARPC5: view

Pathways & Interactions for ARPC5 Gene

genes like me logo Genes that share pathways with ARPC5: view

Gene Ontology (GO) - Biological Process for ARPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 9230079
GO:0007411 axon guidance TAS --
GO:0030833 regulation of actin filament polymerization IEA --
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with ARPC5: view

No data available for SIGNOR curated interactions for ARPC5 Gene

Drugs & Compounds for ARPC5 Gene

(2) Drugs for ARPC5 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one Experimental Pharma Target 0
N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide Experimental Pharma Target 0
genes like me logo Genes that share compounds with ARPC5: view

Transcripts for ARPC5 Gene

Unigene Clusters for ARPC5 Gene

Actin related protein 2/3 complex, subunit 5, 16kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARPC5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b
SP1: - - -
SP2: - -
SP3: - -
SP4:

Relevant External Links for ARPC5 Gene

GeneLoc Exon Structure for
ARPC5
ECgene alternative splicing isoforms for
ARPC5

Expression for ARPC5 Gene

mRNA expression in normal human tissues for ARPC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARPC5 Gene

This gene is overexpressed in Whole Blood (x9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARPC5 Gene



SOURCE GeneReport for Unigene cluster for ARPC5 Gene Hs.518609

genes like me logo Genes that share expression patterns with ARPC5: view

Protein tissue co-expression partners for ARPC5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARPC5 Gene

Orthologs for ARPC5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARPC5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARPC5 35
  • 93.82 (n)
  • 98.68 (a)
ARPC5 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARPC5 35
  • 92.05 (n)
  • 99.34 (a)
ARPC5 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arpc5 35
  • 91.83 (n)
  • 99.34 (a)
Arpc5 16
Arpc5 36
  • 99 (a)
OneToMany
Gm16372 36
  • 89 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ARPC5 35
  • 100 (n)
  • 100 (a)
ARPC5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arpc5 35
  • 92.94 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia ARPC5 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARPC5 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARPC5 35
  • 82.78 (n)
  • 95.36 (a)
ARPC5 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 94 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia arpc5 35
  • 75.78 (n)
  • 86 (a)
Str.319 35
zebrafish
(Danio rerio)
Actinopterygii arpc5a 35
  • 74.67 (n)
  • 84 (a)
arpc5a 36
  • 83 (a)
OneToMany
arpc5b 36
  • 81 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2688 35
fruit fly
(Drosophila melanogaster)
Insecta p16-ARC 37
  • 53 (a)
Arpc5 35
  • 58.85 (n)
  • 53.79 (a)
p16-ARC 36
  • 49 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008895 35
  • 33.33 (n)
  • 15.86 (a)
worm
(Caenorhabditis elegans)
Secernentea arx-7 35
  • 50 (n)
  • 42.67 (a)
arx-7 36
  • 41 (a)
ManyToMany
C46H11.3 36
  • 36 (a)
ManyToMany
Species with no ortholog for ARPC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARPC5 Gene

ENSEMBL:
Gene Tree for ARPC5 (if available)
TreeFam:
Gene Tree for ARPC5 (if available)

Paralogs for ARPC5 Gene

Paralogs for ARPC5 Gene

(1) SIMAP similar genes for ARPC5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARPC5: view

Variants for ARPC5 Gene

Sequence variations from dbSNP and Humsavar for ARPC5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2254972 -- 183,633,660(+) TAGCA(A/G)TCTCT intron-variant
rs2231236 -- 183,633,239(-) TTTTT(A/G)TATGT intron-variant
rs2231237 -- 183,633,220(-) TCATA(A/G)GAACC intron-variant
rs2231238 -- 183,632,941(-) AGGTA(A/T)AAATT intron-variant
rs2231239 -- 183,632,940(-) GGTAA(A/G)AATTT intron-variant

Variation tolerance for ARPC5 Gene

Residual Variation Intolerance Score: 46.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARPC5 Gene

HapMap Linkage Disequilibrium report
ARPC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARPC5 Gene

Disorders for ARPC5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARPC5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lung squamous cell carcinoma
  • epidermoid cell carcinoma of the lung
- elite association - COSMIC cancer census association via MalaCards
Search ARPC5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ARPC5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARPC5
genes like me logo Genes that share disorders with ARPC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARPC5 Gene

Publications for ARPC5 Gene

  1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PMID: 9230079) Welch M.D. … Mitchison T.J. (J. Cell Biol. 1997) 2 3 4 67
  2. Identification and characterisation of a novel human isoform of Arp2/3 complex subunit p16-ARC/ARPC5. (PMID: 12451597) Millard T.H. … Machesky L.M. (Cell Motil. Cytoskeleton 2003) 3 23
  3. Identification of the p16-Arc subunit of the Arp 2/3 complex as a substrate of MAPK-activated protein kinase 2 by proteomic analysis. (PMID: 12829704) Singh S. … McLeish K.R. (J. Biol. Chem. 2003) 3 23
  4. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. (PMID: 9359840) Machesky L.M. … Segal A.W. (Biochem. J. 1997) 2 3
  5. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3

Products for ARPC5 Gene

Sources for ARPC5 Gene

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