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Aliases for ARPC5 Gene

Aliases for ARPC5 Gene

  • Actin Related Protein 2/3 Complex Subunit 5 2 3 5
  • Arp2/3 Protein Complex Subunit P16 2 3
  • Arp2/3 Complex 16 KDa Subunit 3 4
  • P16-Arc 3 4
  • ARC16 3 4
  • Actin Related Protein 2/3 Complex, Subunit 5 (16 KD) 2
  • Actin Related Protein 2/3 Complex, Subunit 5, 16kDa 3
  • Actin Related Protein 2/3 Complex Subunit 5, 16kDa 2
  • Actin-Related Protein 2/3 Complex Subunit 5 3
  • DJ127C7.3 3

External Ids for ARPC5 Gene

Previous GeneCards Identifiers for ARPC5 Gene

  • GC01M181121
  • GC01M179023
  • GC01M180112
  • GC01M180834
  • GC01M180326
  • GC01M181859
  • GC01M154832

Summaries for ARPC5 Gene

Entrez Gene Summary for ARPC5 Gene

  • This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for ARPC5 Gene

ARPC5 (Actin Related Protein 2/3 Complex Subunit 5) is a Protein Coding gene. Among its related pathways are Immune response CCR3 signaling in eosinophils and Innate Immune System. GO annotations related to this gene include actin filament binding and structural constituent of cytoskeleton. An important paralog of this gene is ARPC5L.

UniProtKB/Swiss-Prot for ARPC5 Gene

  • Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

Gene Wiki entry for ARPC5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARPC5 Gene

Genomics for ARPC5 Gene

Regulatory Elements for ARPC5 Gene

Enhancers for ARPC5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G183602 1.9 FANTOM5 Ensembl ENCODE dbSUPER 30.2 +29.2 29241 8.2 HDGF PKNOX1 FOXA2 ATF1 ZNF133 YBX1 YY1 ZNF121 GATA2 ELK1 NCF2 ARPC5 RGL1 APOBEC4 SMG7 GC01M183620
GH01G183632 1.4 ENCODE dbSUPER 19.8 +1.2 1223 4.6 CREB3L1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 MEF2D NCF2 ARPC5 ENSG00000271387 GC01M183630
GH01G183622 1.3 Ensembl ENCODE dbSUPER 19.4 +12.9 12876 1.3 GTF2F1 TBP CTCF MXI1 ARID4B MAX RAD21 RELA RFX5 FOXK2 ARPC5 GC01M183620 GC01M183630
GH01G183588 1.5 FANTOM5 ENCODE dbSUPER 13.4 +45.8 45807 2.8 HDGF TBP PKNOX1 TBL1XR1 BMI1 ZBTB40 ZNF23 EGR1 ZNF207 RELB NCF2 ARPC5 SMG7-AS1 SMG7 LOC100526839
GH01G183651 1.1 Ensembl ENCODE 17.2 -17.0 -17023 2.8 TBP PKNOX1 ARID4B BMI1 ZNF2 RAD21 ZBTB40 SCRT2 ZNF143 RELB ARPC5 APOBEC4 RGL1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARPC5 on UCSC Golden Path with GeneCards custom track

Promoters for ARPC5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000016877 1341 4401 CREB3L1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 MEF2D

Genomic Location for ARPC5 Gene

Chromosome:
1
Start:
183,620,846 bp from pter
End:
183,635,941 bp from pter
Size:
15,096 bases
Orientation:
Minus strand

Genomic View for ARPC5 Gene

Genes around ARPC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARPC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARPC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPC5 Gene

Proteins for ARPC5 Gene

  • Protein details for ARPC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15511-ARPC5_HUMAN
    Recommended name:
    Actin-related protein 2/3 complex subunit 5
    Protein Accession:
    O15511
    Secondary Accessions:
    • A6NEC4
    • Q6PG42

    Protein attributes for ARPC5 Gene

    Size:
    151 amino acids
    Molecular mass:
    16320 Da
    Quaternary structure:
    • Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

    Alternative splice isoforms for ARPC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARPC5 Gene

Post-translational modifications for ARPC5 Gene

  • Polyubiquitinated by RNF128 with Lys-63-linked chains, leading to proteasomal degradation.
  • Ubiquitination at posLast=33, Lys60, posLast=6767, Lys100, posLast=108108, posLast=112112, and posLast=131131
  • Modification sites at PhosphoSitePlus

Other Protein References for ARPC5 Gene

Antibody Products

  • Abcam antibodies for ARPC5
  • Santa Cruz Biotechnology (SCBT) Antibodies for ARPC5

No data available for DME Specific Peptides for ARPC5 Gene

Domains & Families for ARPC5 Gene

Gene Families for ARPC5 Gene

Protein Domains for ARPC5 Gene

Suggested Antigen Peptide Sequences for ARPC5 Gene

Graphical View of Domain Structure for InterPro Entry

O15511

UniProtKB/Swiss-Prot:

ARPC5_HUMAN :
  • Belongs to the ARPC5 family.
Family:
  • Belongs to the ARPC5 family.
genes like me logo Genes that share domains with ARPC5: view

Function for ARPC5 Gene

Molecular function for ARPC5 Gene

UniProtKB/Swiss-Prot Function:
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

Gene Ontology (GO) - Molecular Function for ARPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton TAS,IDA 11741539
GO:0005515 protein binding IPI 11162547
GO:0051015 contributes_to actin filament binding IDA 11741539
genes like me logo Genes that share ontologies with ARPC5: view
genes like me logo Genes that share phenotypes with ARPC5: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARPC5 Gene

Localization for ARPC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARPC5 Gene

Cytoplasm, cytoskeleton. Cell projection.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARPC5 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
endosome 2
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ARPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm TAS 9359840
GO:0005768 endosome IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ARPC5: view

Pathways & Interactions for ARPC5 Gene

genes like me logo Genes that share pathways with ARPC5: view

Gene Ontology (GO) - Biological Process for ARPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 9230079
GO:0014909 smooth muscle cell migration IEA --
GO:0016477 cell migration IMP 22378351
GO:0021769 orbitofrontal cortex development IEA --
GO:0030011 maintenance of cell polarity IEA --
genes like me logo Genes that share ontologies with ARPC5: view

No data available for SIGNOR curated interactions for ARPC5 Gene

Drugs & Compounds for ARPC5 Gene

(2) Drugs for ARPC5 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one Experimental Pharma Target 0
N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide Experimental Pharma Target 0
genes like me logo Genes that share compounds with ARPC5: view

Transcripts for ARPC5 Gene

Unigene Clusters for ARPC5 Gene

Actin related protein 2/3 complex, subunit 5, 16kDa:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARPC5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b
SP1: - - -
SP2: - -
SP3: - -
SP4:

Relevant External Links for ARPC5 Gene

GeneLoc Exon Structure for
ARPC5
ECgene alternative splicing isoforms for
ARPC5

Expression for ARPC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARPC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARPC5 Gene

This gene is overexpressed in Whole Blood (x9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARPC5 Gene



Protein tissue co-expression partners for ARPC5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARPC5 Gene:

ARPC5

SOURCE GeneReport for Unigene cluster for ARPC5 Gene:

Hs.518609

Evidence on tissue expression from TISSUES for ARPC5 Gene

  • Nervous system(4.8)
  • Blood(4.7)
  • Liver(4.4)
  • Skin(4.4)
  • Intestine(3.5)
  • Lung(3.3)
  • Kidney(2.4)
  • Gall bladder(2.2)
  • Lymph node(2.1)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with ARPC5: view

Primer Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARPC5 Gene

Orthologs for ARPC5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARPC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARPC5 35 34
  • 100 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARPC5 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARPC5 35 34
  • 93.82 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arpc5 34
  • 92.94 (n)
dog
(Canis familiaris)
Mammalia ARPC5 35 34
  • 92.05 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Arpc5 16 35 34
  • 91.83 (n)
Gm16372 35
  • 89 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ARPC5 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARPC5 35 34
  • 82.78 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 94 (a)
OneToMany
-- 35
  • 94 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia arpc5 34
  • 75.78 (n)
Str.319 34
zebrafish
(Danio rerio)
Actinopterygii arpc5b 35
  • 81 (a)
OneToMany
arpc5a 35 34
  • 74.67 (n)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2688 34
fruit fly
(Drosophila melanogaster)
Insecta Arpc5 34
  • 58.85 (n)
p16-ARC 36 35
  • 53 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008895 34
  • 33.33 (n)
worm
(Caenorhabditis elegans)
Secernentea arx-7 34 35
  • 50 (n)
C46H11.3 35
  • 36 (a)
ManyToMany
Species where no ortholog for ARPC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARPC5 Gene

ENSEMBL:
Gene Tree for ARPC5 (if available)
TreeFam:
Gene Tree for ARPC5 (if available)

Paralogs for ARPC5 Gene

Paralogs for ARPC5 Gene

(1) SIMAP similar genes for ARPC5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARPC5: view

Variants for ARPC5 Gene

Sequence variations from dbSNP and Humsavar for ARPC5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000194118 -- 183,634,762(+) ACACG(C/G)ATTCC intron-variant, upstream-variant-2KB
rs1000349050 -- 183,628,334(+) TCAGA(-/T)TTTTT intron-variant
rs1000356554 -- 183,632,926(+) TATTT(C/T)TTCAC intron-variant
rs1000691769 -- 183,634,980(+) ACAGT(C/T)CCATC intron-variant, upstream-variant-2KB
rs1000899543 -- 183,632,072(+) CCAAA(G/T)AAATT intron-variant

Variation tolerance for ARPC5 Gene

Residual Variation Intolerance Score: 46.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARPC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARPC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARPC5 Gene

Disorders for ARPC5 Gene

Relevant External Links for ARPC5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARPC5

No disorders were found for ARPC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARPC5 Gene

Publications for ARPC5 Gene

  1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PMID: 9230079) Welch M.D. … Mitchison T.J. (J. Cell Biol. 1997) 2 3 4 64
  2. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. (PMID: 9359840) Machesky L.M. … Segal A.W. (Biochem. J. 1997) 2 3 4 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Identification and characterisation of a novel human isoform of Arp2/3 complex subunit p16-ARC/ARPC5. (PMID: 12451597) Millard T.H. … Machesky L.M. (Cell Motil. Cytoskeleton 2003) 3 22 64

Products for ARPC5 Gene

Sources for ARPC5 Gene

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