Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARPC5 Gene

protein-coding   GIFtS: 61
GCID: GC01M183592

actin related protein 2/3 complex, subunit 5, 16kDa

(Previous names: actin related protein 2/3 complex, subunit 5 (16 kD) )
 Explore 4 diseases affiliated with
ARPC5 via our new
 Human Malady Compendium 
Biological research products
for ARPC5
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Actin Related Protein 2/3 Complex, Subunit 5, 16kDa1 2     Actin Related Protein 2/3 Complex, Subunit 5 (16 KD)1
ARC161 2 3     Actin-Related Protein 2/3 Complex Subunit 52
DJ127C7.31     Arp2/3 Protein Complex Subunit P162
P16-Arc1     P16-ARC1
Arp2/3 Complex 16 KDa Subunit2 3     

External Ids:    HGNC: 7081   Entrez Gene: 100922   Ensembl: ENSG000001627047   OMIM: 6042275   UniProtKB: O155113   

Export aliases for ARPC5 gene to outside databases

Previous GC identifers: GC01M181121 GC01M179023 GC01M180112 GC01M180834 GC01M180326 GC01M181859 GC01M154832


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARPC5:
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been
implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of
the protein encoded by this gene, the p16 subunit, has yet to be determined. Alternatively spliced transcript variants
encoding different isoforms have been observed for this gene. (provided by RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: ARPC5_HUMAN, O15511
Function: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and
together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks

Gene Wiki entry for ARPC5


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARPC5 gene promoter:
         AhR   Sox5   AML1a   Cdc5   NF-AT   C/EBPalpha   Arnt   NF-AT2   NF-AT1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARPC5 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARPC5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARPC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.3   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q

ARPC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARPC5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M183592:  view genomic region     (about GC identifiers)

Start:
183,592,401 bp from pter      End:
183,604,985 bp from pter
Size:
12,585 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ARPC5_HUMAN, O15511 (See protein sequence)
Recommended Name: Actin-related protein 2/3 complex subunit 5  
Size: 151 amino acids; 16320 Da
Subunit: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC,
ARPC4/p20-ARC and ARPC5/p16-ARC
Subcellular location: Cytoplasm, cytoskeleton. Cell projection
Secondary accessions: A6NEC4 Q6PG42
Alternative splicing: 2 isoforms:  O15511-1   O15511-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARPC5: NX_O15511

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15511

  • ARPC5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001257368.1  NP_005708.1  

    ENSEMBL proteins: 
     ENSP00000356504   ENSP00000352918   ENSP00000294742  
    Reactome Protein details: O15511
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: ARPC5
    OriGene Protein Over-expression Lysate: ARPC5
    OriGene Custom Protein Services for ARPC5 
    GenScript Custom Purified and Recombinant Proteins Services for ARPC5
    Novus Biologicals ARPC5 Proteins
    Novus Biologicals ARPC5 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for ARPC5
    Uscn Proteins for ARPC5

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton ----
    GO:0005885Arp2/3 protein complex TAS9230079
    GO:0015629actin cytoskeleton TAS9230079
    GO:0030027lamellipodium IEA--


    ARPC5 for ontologies           About GeneDecksing



    ARPC5 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ARPC5
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 2): ARPC5
    OriGene Custom Antibody Services for ARPC5 
    GenScript Custom Superior Antibodies Services for ARPC5
    Novus Biologicals ARPC5 Antibodies
    Abcam antibodies for ARPC5 
    Uscn Antibodies for ARPC5
    Search ThermoFisher Antibodies for ARPC5

    Assay Products for ARPC5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ARPC5
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ARPC5


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ARPC5 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR006789 ARP2/3_p16_Arc

    Graphical View of Domain Structure for InterPro Entry O15511

    ProtoNet protein and cluster: O15511

    1 Blocks protein family: IPB006789 ARP2/3 complex 16 kDa subunit (p16-Arc)

    UniProtKB/Swiss-Prot: ARPC5_HUMAN, O15511
    Similarity: Belongs to the ARPC5 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ARPC5_HUMAN, O15511
    Function: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and
    together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks

    miRNA
    Products:
        
    miRTarBase miRNAs that target ARPC5:
    hsa-mir-31 (MIRT004981)

    OriGene 3'-UTR Clone: ARPC5
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARPC5
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate ARPC5 (see all 37):
    hsa-miR-2052 hsa-miR-19b-2* hsa-miR-4328 hsa-miR-4272 hsa-miR-200a hsa-miR-30d hsa-miR-141 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidARPC5 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARPC5 (see all 7)
    OriGene shRNA RFP: ARPC5
    OriGene siRNA: ARPC5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARPC5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ARPC5

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARPC5 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARPC5
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ARPC5 (NM_005717)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARPC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARPC5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ARPC5
    Search LifeMap BioReagents cell lines for ARPC5

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARPC5

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005200structural constituent of cytoskeleton TAS9230079
    GO:0005515protein binding IPI11162547


    ARPC5 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ARPC5:
     Decreased focal adhesion (FA)  


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/17 super-pathways (see all 17About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell adhesion_Integrin-mediated cell adhesion and migration
    Cell adhesion_Integrin-mediated cell adhesion and migration1.00
    Cytoskeleton remodeling_Integrin outside-in signaling0.37
    Cell adhesion Integrin-mediated cell adhesion and migration1.00
    Cytoskeleton remodeling Integrin outside-in signaling0.37
    Cytoskeleton remodeling_Regulation of actin cytoskeleton by Rho GTPases0.49
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility0.32
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    Cytoskeleton remodeling_Fibronectin-binding integrins in cell motility0.32
    2G-protein signaling_RAC1 in cellular process
    G-protein signaling_RAC1 in cellular process1.00
    Cytoskeleton remodeling CDC42 in cellular processes0.37
    G-protein signaling RAC1 in cellular process1.00
    RAC1 signaling pathway0.34
    Cytoskeleton remodeling_CDC42 in cellular processes0.37
    CDC42 signaling events0.17
    3Regulation of actin dynamics for phagocytic cup formation
    Regulation of actin dynamics for phagocytic cup formation1.00
    Fcgamma receptor (FCGR) dependent phagocytosis0.80
    Role of myosins in phagosome formation0.80
    Branching and elongation of mother and daughter filaments0.29
    4Cytoskeleton remodeling Slit-Robo signaling
    Cytoskeleton remodeling Slit-Robo signaling1.00
    Cell adhesion_Cadherin-mediated cell adhesion0.28
    Development_Slit-Robo signaling0.92
    Cell adhesion Cadherin-mediated cell adhesion0.28
    5Immune response CD16 signaling in NK cells
    Immune response CD16 signaling in NK cells1.00
    Immune response_Role of DAP12 receptors in NK cells0.32
    Immune response_CD16 signaling in NK cells0.99
    Immune response Role of DAP12 receptors in NK cells0.32

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/13 EMD Millipore Pathways for ARPC5 (see all 13)
        Cytoskeleton remodeling Integrin outside-in signaling
    Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling CDC42 in cellular processes
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Immune response Role of DAP12 receptors in NK cells

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ARPC5
        Salmonella Infection

    5/14 GeneGo (Thomson Reuters) Pathways for ARPC5 (see all 14)
        Cytoskeleton remodeling CDC42 in cellular processes
    Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling Integrin outside-in signaling

    5/6 BioSystems Pathways for ARPC5 (see all 6
        Regulation of Actin Cytoskeleton
    Pathogenic Escherichia coli infection
    B Cell Receptor Signaling Pathway
    RAC1 signaling pathway
    CDC42 signaling events

    5/6        Reactome Pathways for ARPC5 (see all 6)
        Role of myosins in phagosome formation
    Branching and elongation of mother and daughter filaments
    Regulation of actin dynamics for phagocytic cup formation
    Fcgamma receptor (FCGR) dependent phagocytosis
    Immune System


    5         Kegg Pathways  (Kegg details for ARPC5):
        Fc gamma R-mediated phagocytosis
    Regulation of actin cytoskeleton
    Bacterial invasion of epithelial cells
    Pathogenic Escherichia coli infection
    Shigellosis


    ARPC5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARPC5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/39 Interacting proteins for ARPC5 (O155113 ENSP000003529184) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTR2P611603, ENSP000003672204I2D: score=3 STRING: ENSP00000367220
    MAPKAPK2P491373, ENSP000003560704I2D: score=3 STRING: ENSP00000356070
    ACTR3BQ9P1U13, ENSP000002560014I2D: score=2 STRING: ENSP00000256001
    ARPC1BO151433, ENSP000002527254I2D: score=2 STRING: ENSP00000252725
    EIF3HO153723, ENSP000002766824I2D: score=2 STRING: ENSP00000276682
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement TAS9230079
    GO:0030036actin cytoskeleton organization TAS9359840
    GO:0030833regulation of actin filament polymerization IEA--


    ARPC5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARPC5

    2 DrugBank Compounds for ARPC5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one-- --target--10592235
    N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about ARPC5 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARPC5 gene (2 alternative transcripts): 
    NM_001270439.1  NM_005717.3  

    Unigene Cluster for ARPC5:

    Actin related protein 2/3 complex, subunit 5, 16kDa
    Hs.518609  [show with all ESTs]
    Unigene Representative Sequence: BC034231
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367534 ENST00000462965(uc021pgb.1) ENST00000359856(uc001gql.3)
    ENST00000294742

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: ARPC5
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARPC5
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate ARPC5 (see all 37):
    hsa-miR-2052 hsa-miR-19b-2* hsa-miR-4328 hsa-miR-4272 hsa-miR-200a hsa-miR-30d hsa-miR-141 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidARPC5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARPC5 (see all 7)
    OriGene shRNA RFP: ARPC5
    OriGene siRNA: ARPC5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARPC5
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARPC5 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARPC5
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ARPC5 (NM_005717)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARPC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARPC5 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARPC5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARPC5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARPC5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARPC5

    Additional cDNA sequence: 

    AF006088.1 AF017807.1 AK129598.1 BC034231.1 BC057237.1 

    23 DOTS entries:

    DT.100855250  DT.452009  DT.100664916  DT.100664913  DT.91987547  DT.100871584  DT.100848067  DT.100664917 
    DT.121439947  DT.97860335  DT.95124056  DT.100664905  DT.100664903  DT.95164119  DT.100045599  DT.100676115 
    DT.121439949  DT.121439990  DT.418857  DT.91769832  DT.95164095  DT.95164096  DT.100664909 

    24/730 AceView cDNA sequences (see all 730):

    BM671273 BM838125 BU186286 BM457490 BM836765 AI935831 AI992112 AI872444 
    AA625401 BP376266 AI744392 AW105646 CA427477 BC034231 BP366812 CA307842 
    BQ027022 AW104908 AW780272 CA389124 BG679035 BE504357 AU141398 BM976332 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ARPC5    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b
    SP1:                    -     -                 -               
    SP2:                    -                       -               
    SP3:                    -     -                                 
    SP4:                                                            


    ECgene alternative splicing isoforms for ARPC5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARPC5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AACATCAAAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ARPC5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARPC5

    SOURCE GeneReport for Unigene cluster: Hs.518609
        SABiosciences Expression via Pathway-Focused PCR Array including ARPC5: 
              Cytoskeleton Regulators in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARPC5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARPC5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARPC5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARPC5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARPC5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARPC5 gene from 8/27 species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ARPC51 actin related protein 2/3 complex, subunit 5, 16kDa 82.78(n)
    95.36(a)
      429075  NM_001031561.1  NP_001026732.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARPC56
    ARPC56
    --
    94(a)
    93(a)
    1 ↔ many
    1 ↔ many
    AAWZ02037649(3027-12079)
    GL343203.1(4048542-4050950)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF547300.12   -- 79.73(n)    CF547300.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AY394953.12   -- 77.21(n)    AY394953.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta p16-ARC1 , 3 actin binding3
    CG9881-PA1
    53(a)3
    58.85(n)1
    53.79(a)1
      23A13
    334441  NM_134849.21  NP_608693.11 
    worm
    (Caenorhabditis elegans)
    Secernentea arx-76
    C46H11.36
    ARp2/3 compleX component family member (arx-7)
    Probable actin-related protein 2/3 complex subunit...
    38(a)
    34(a)
    many ↔ many
    many ↔ many
    I(3069234-3070142)
    I(5041492-5042055)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CRK6
    AT5G652746
    ARP2/3 complex 16 kDa subunit (p16-Arc)
    30(a)
    27(a)
    many ↔ many
    many ↔ many
    4(735753-736604)
    5(26085300-26085960)
    rice
    (Oryza sativa)
    Liliopsida --
    actin polymerization factor, putative, expressed
    25(a)
    1 → many
    11(20263435-20265444)


    ENSEMBL Gene Tree for ARPC5 (if available)
    TreeFam Gene Tree for ARPC5 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARPC5 gene
    ARPC5L2  
    1 SIMAP similar gene for ARPC5 using alignment to 3 protein entries:     ARPC5_HUMAN (see all proteins):
    ARPC5L

    ARPC5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/235 NCBI SNPs in ARPC5 are shown (see all 235    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs75171631,2
    C,F,--183594872(+) TAATAC/ACTATT 2 -- ds50016Minor allele frequency- A:0.11NA WA EA 500
    rs1432134081,2
    --183594927(+) GTTTTA/GAAGTG 2 -- ds50010--------
    rs1843549321,2
    --183594987(+) GGTAAA/GTACAA 2 -- ds50010--------
    rs27615741,2
    C,F,O,A,--183595037(+) TGGGAG/ATGAAT 2 -- ds500115Minor allele frequency- A:0.35NA EA CSA WA 867
    rs1508698881,2
    --183595042(+) GTGAAC/TGACTG 2 -- ds50010--------
    rs75421361,2
    C,F,A,--183595057(+) TGCTAA/GGCTAC 2 -- ds50016Minor allele frequency- G:0.11NA WA EA 496
    rs38561271,2
    C,F,A,--183595069(+) TTGCAC/GTTTCT 2 -- ds500111Minor allele frequency- G:0.20NA CSA WA EA 508
    rs75423041,2
    C,F,H,--183595180(+) TCATGA/CCTCTC 2 -- ds500117Minor allele frequency- C:0.10NS EA NA WA 2340
    rs1881756021,2
    --183595193(+) CTCTAC/TCATCT 2 -- ds50010--------
    rs1817600541,2
    --183595200(+) ATCTTA/GTATCT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for ARPC5 (183592401 - 183604985 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ARPC5: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARPC5
    DNA2.0 Custom Variant and Variant Library Synthesis for ARPC5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ARPC5 for disorders           About GeneDecksing

    OMIM gene information: 604227    OMIM disorders: --

    4 diseases for ARPC5:    About MalaCards
    lung squamous cell carcinoma    squamous cell carcinoma    shigellosis    carcinoma


    Export disorders for ARPC5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARPC5 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with ARPC5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PubMed id 9230079)1, 2, 3 Welch M.D.... Mitchison T.J. (1997)
    2. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. (PubMed id 9359840)1, 2, 3 Machesky L.M.... Segal A.W. (1997)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    6. Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. (PubMed id 11741539)1, 2 Gournier H.... Welch M.D. (2001)
    7. Identification of the p16-Arc subunit of the Arp 2/3 complex as a substrate of MAPK-activated protein kinase 2 by proteomic analysis. (PubMed id 12829704)1, 9 Singh S....McLeish K.R. (2003)
    8. Identification and characterisation of a novel human isoform of Arp2/3 complex subunit p16-ARC/ARPC5. (PubMed id 12451597)1, 9 Millard T.H....Machesky L.M. (2003)
    9. Insertions within the actin core of actin-related prot ein 3 (Arp3) modulate branching nucleation by Arp2/3 complex. (PubMed id 23148219)1 Liu S.L....Nolen B.J. (2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10092 HGNC: 708 AceView: ARPC5 Ensembl:ENSG00000162704 euGenes: HUgn10092
    ECgene: ARPC5 Kegg: 10092 H-InvDB: ARPC5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARPC5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARPC5 gene:
    Search GeneIP for patents involving ARPC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Small Molecules at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ARPC5
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for ARPC5   OriGene shRNA RFP for ARPC5  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARPC5   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARPC5  
     OriGene Protein Over-expression Lysate for ARPC5   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ARPC5   OriGene 3'-UTR Clone for ARPC5  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARPC5   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARPC5  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for ARPC5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ARPC5   OriGene Custom Protein Services for ARPC5  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARPC5
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARPC5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARPC5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARPC5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARPC5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARPC5
     GenScript Custom Purified and Recombinant Proteins Services for ARPC5 GenScript cDNA clones with any tag delivered in your preferred vector for ARPC5
     GenScript Custom Assay Services for ARPC5 GenScript Custom Superior Antibodies Services for ARPC5
     GenScript Custom overexpressing Cell Line Services for ARPC5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ARPC5 promoter
     Search Chromatin IP Primers for ARPC5
     RT2 qPCR Primer Assay in human, mouse, rat ARPC5
     GNC Network for ARPC5
     SABiosciences PCR Arrays including human, mouse, rat ARPC5
     Search Tocris compounds for ARPC5
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ARPC5 antibodies
     ARPC5 proteins
     ARPC5 lysates
     Antibodies for ARPC5
     See all of Abcam's Antibodies, Kits and Proteins for ARPC5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for ARPC5




     ARPC5 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ARPC5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARPC5
     SwitchGear 3'UTR luciferase reporter plasmids for ARPC5
     SwitchGear Promoter luciferase reporter plasmids for ARPC5
     Search ThermoFisher Antibodies for ARPC5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARPC5
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ARPC5 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4