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Aliases for ARPC5 Gene

Aliases for ARPC5 Gene

  • Actin Related Protein 2/3 Complex, Subunit 5, 16kDa 2 3
  • Arp2/3 Protein Complex Subunit P16 2 3
  • Arp2/3 Complex 16 KDa Subunit 3 4
  • P16-Arc 3 4
  • ARC16 3 4
  • Actin Related Protein 2/3 Complex, Subunit 5 (16 KD) 2
  • Actin-Related Protein 2/3 Complex Subunit 5 3
  • DJ127C7.3 3

External Ids for ARPC5 Gene

Summaries for ARPC5 Gene

Entrez Gene Summary for ARPC5 Gene

  • This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for ARPC5 Gene

ARPC5 (Actin Related Protein 2/3 Complex, Subunit 5, 16kDa) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and Regulation of actin cytoskeleton. GO annotations related to this gene include actin binding and structural constituent of cytoskeleton. An important paralog of this gene is ARPC5L.

UniProtKB/Swiss-Prot for ARPC5 Gene

  • Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks

Gene Wiki entry for ARPC5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARPC5 Gene

Genomics for ARPC5 Gene

Genomic Location for ARPC5 Gene

Start:
183,620,846 bp from pter
End:
183,635,941 bp from pter
Size:
15,096 bases
Orientation:
Minus strand

Genomic View for ARPC5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARPC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPC5 Gene

Regulatory Elements for ARPC5 Gene

Proteins for ARPC5 Gene

  • Protein details for ARPC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15511-ARPC5_HUMAN
    Recommended name:
    Actin-related protein 2/3 complex subunit 5
    Protein Accession:
    O15511
    Secondary Accessions:
    • A6NEC4
    • Q6PG42

    Protein attributes for ARPC5 Gene

    Size:
    151 amino acids
    Molecular mass:
    16320 Da
    Quaternary structure:
    • Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC

    Alternative splice isoforms for ARPC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARPC5 Gene

Proteomics data for ARPC5 Gene at MOPED

Post-translational modifications for ARPC5 Gene

  • Polyubiquitinated by RNF128 with Lys-63-linked chains, leading to proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys3, Lys60, Lys67, Lys100, Lys108, Lys112, and Lys131

Other Protein References for ARPC5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ARPC5 Gene

Domains for ARPC5 Gene

Gene Families for ARPC5 Gene

HGNC:
  • ARPC :Actin related protein 2/3 complex subunits

Protein Domains for ARPC5 Gene

UniProtKB/Swiss-Prot:

ARPC5_HUMAN
Family:
  • Belongs to the ARPC5 family.:
    • O15511
genes like me logo Genes that share domains with ARPC5: view

Function for ARPC5 Gene

Molecular function for ARPC5 Gene

UniProtKB/Swiss-Prot Function: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks

Gene Ontology (GO) - Molecular Function for ARPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton IDA 11741539
GO:0005515 protein binding IPI 11162547
GO:0051015 contributes_to actin filament binding IDA 11741539
genes like me logo Genes that share ontologies with ARPC5: view

Phenotypes for ARPC5 Gene

GenomeRNAi human phenotypes for ARPC5:
genes like me logo Genes that share phenotypes with ARPC5: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARPC5 Gene

Localization for ARPC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARPC5 Gene

Cytoplasm, cytoskeleton. Cell projection.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARPC5 Gene COMPARTMENTS Subcellular localization image for ARPC5 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ARPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9359840
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton --
GO:0005885 Arp2/3 protein complex IDA 11741539
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with ARPC5: view

Pathways for ARPC5 Gene

genes like me logo Genes that share pathways with ARPC5: view

Gene Ontology (GO) - Biological Process for ARPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 9230079
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007411 axon guidance TAS --
GO:0016477 cell migration IMP 22378351
GO:0030036 actin cytoskeleton organization TAS 9359840
genes like me logo Genes that share ontologies with ARPC5: view

Transcripts for ARPC5 Gene

Unigene Clusters for ARPC5 Gene

Actin related protein 2/3 complex, subunit 5, 16kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARPC5 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b
SP1: - - -
SP2: - -
SP3: - -
SP4:

Relevant External Links for ARPC5 Gene

GeneLoc Exon Structure for
ARPC5
ECgene alternative splicing isoforms for
ARPC5

Expression for ARPC5 Gene

mRNA expression in normal human tissues for ARPC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARPC5 Gene

This gene is overexpressed in Whole Blood (9.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ARPC5 Gene

SOURCE GeneReport for Unigene cluster for ARPC5 Gene Hs.518609

genes like me logo Genes that share expressions with ARPC5: view

Orthologs for ARPC5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARPC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARPC5 36
  • 100 (n)
  • 100 (a)
ARPC5 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARPC5 36
  • 93.82 (n)
  • 98.68 (a)
ARPC5 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARPC5 36
  • 92.05 (n)
  • 99.34 (a)
ARPC5 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arpc5 36
  • 91.83 (n)
  • 99.34 (a)
Arpc5 16
Arpc5 37
  • 99 (a)
OneToMany
Gm16372 37
  • 89 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ARPC5 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARPC5 37
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arpc5 36
  • 92.94 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves ARPC5 36
  • 82.78 (n)
  • 95.36 (a)
ARPC5 37
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 94 (a)
OneToMany
-- 37
  • 94 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia arpc5 36
  • 75.78 (n)
  • 86 (a)
Str.319 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2688 36
zebrafish
(Danio rerio)
Actinopterygii arpc5a 36
  • 74.67 (n)
  • 84 (a)
arpc5a 37
  • 83 (a)
OneToMany
arpc5b 37
  • 81 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008895 36
  • 33.33 (n)
  • 15.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta Arpc5 36
  • 58.85 (n)
  • 53.79 (a)
p16-ARC 37
  • 49 (a)
OneToMany
p16-ARC 38
  • 53 (a)
worm
(Caenorhabditis elegans)
Secernentea arx-7 36
  • 50 (n)
  • 42.67 (a)
arx-7 37
  • 41 (a)
ManyToMany
C46H11.3 37
  • 36 (a)
ManyToMany
Species with no ortholog for ARPC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARPC5 Gene

ENSEMBL:
Gene Tree for ARPC5 (if available)
TreeFam:
Gene Tree for ARPC5 (if available)

Paralogs for ARPC5 Gene

Paralogs for ARPC5 Gene

Selected SIMAP similar genes for ARPC5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARPC5: view

Variants for ARPC5 Gene

Sequence variations from dbSNP and Humsavar for ARPC5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs11755 -- 183,627,001(-) ACTGC(C/T)AAGTT utr-variant-3-prime
rs2231236 -- 183,633,239(-) TTTTT(A/G)TATGT intron-variant
rs2231237 -- 183,633,220(-) TCATA(A/G)GAACC intron-variant
rs2231238 -- 183,632,941(-) AGGTA(A/T)AAATT intron-variant
rs2231239 -- 183,632,940(-) GGTAA(A/G)AATTT intron-variant

Relevant External Links for ARPC5 Gene

HapMap Linkage Disequilibrium report
ARPC5

No data available for Structural Variations from Database of Genomic Variants (DGV) for ARPC5 Gene

Disorders for ARPC5 Gene

(1) University of Copenhagen DISEASES for ARPC5 Gene

genes like me logo Genes that share disorders with ARPC5: view

No data available for UniProtKB/Swiss-Prot for ARPC5 Gene

Publications for ARPC5 Gene

  1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PMID: 9230079) Welch M.D. … Mitchison T.J. (J. Cell Biol. 1997) 2 3 4
  2. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. (PMID: 9359840) Machesky L.M. … Segal A.W. (Biochem. J. 1997) 2 3 4
  3. Identification and characterisation of a novel human isoform of Arp2/3 complex subunit p16-ARC/ARPC5. (PMID: 12451597) Millard T.H. … Machesky L.M. (Cell Motil. Cytoskeleton 2003) 3 23
  4. Identification of the p16-Arc subunit of the Arp 2/3 complex as a substrate of MAPK-activated protein kinase 2 by proteomic analysis. (PMID: 12829704) Singh S. … McLeish K.R. (J. Biol. Chem. 2003) 3 23
  5. Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. (PMID: 11741539) Gournier H. … Welch M.D. (Mol. Cell 2001) 3 4

Products for ARPC5 Gene

Sources for ARPC5 Gene

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