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ARPC5 Gene

protein-coding   GIFtS: 63
GCID: GC01M183592

Actin Related Protein 2/3 Complex, Subunit 5, 16kDa

(Previous names: actin related protein 2/3 complex, subunit 5 (16 kD))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Actin Related Protein 2/3 Complex, Subunit 5, 16kDa1 2     Actin-Related Protein 2/3 Complex Subunit 52
Arp2/3 Protein Complex Subunit P161 2     dJ127C7.32
Arp2/3 Complex 16 KDa Subunit2 3     p16-Arc2
ARC162 3     p16-ARC3
Actin Related Protein 2/3 Complex, Subunit 5 (16 KD)1     

External Ids:    HGNC: 7081   Entrez Gene: 100922   Ensembl: ENSG000001627047   OMIM: 6042275   UniProtKB: O155113   

Export aliases for ARPC5 gene to outside databases

Previous GC identifers: GC01M181121 GC01M179023 GC01M180112 GC01M180834 GC01M180326 GC01M181859 GC01M154832


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARPC5 Gene:
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been
implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact
role of the protein encoded by this gene, the p16 subunit, has yet to be determined. Alternatively spliced
transcript variants encoding different isoforms have been observed for this gene. (provided by RefSeq, Jul 2012)

GeneCards Summary for ARPC5 Gene:
ARPC5 (actin related protein 2/3 complex, subunit 5, 16kDa) is a protein-coding gene. Diseases associated with ARPC5 include lung squamous cell carcinoma, and shigellosis. GO annotations related to this gene include actin binding and structural constituent of cytoskeleton. An important paralog of this gene is ARPC5L.

UniProtKB/Swiss-Prot: ARPC5_HUMAN, O15511
Function: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and
together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks

Gene Wiki entry for ARPC5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARPC5 gene promoter:
         AhR   Sox5   AML1a   Cdc5   NF-AT   C/EBPalpha   Arnt   NF-AT2   NF-AT1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARPC5 promoter sequence
   Search Chromatin IP Primers for ARPC5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARPC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.3   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q

ARPC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARPC5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M183592:  view genomic region     (about GC identifiers)

Start:
183,592,401 bp from pter      End:
183,604,985 bp from pter
Size:
12,585 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARPC5_HUMAN, O15511 (See protein sequence)
Recommended Name: Actin-related protein 2/3 complex subunit 5  
Size: 151 amino acids; 16320 Da
Subunit: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC,
ARPC4/p20-ARC and ARPC5/p16-ARC
Secondary accessions: A6NEC4 Q6PG42
Alternative splicing: 2 isoforms:  O15511-1   O15511-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARPC5: NX_O15511

Explore proteomics data for ARPC5 at MOPED

Post-translational modifications: 

  • Polyubiquitinated by RNF128 with 'Lys-63'-linked chains, leading to proteasomal degradation1
  • Ubiquitination2 at Lys3, Lys60, Lys67, Lys100, Lys108, Lys112, Lys131
  • Modification sites at PhosphoSitePlus

  • See ARPC5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001257368.1  NP_005708.1  

    ENSEMBL proteins: 
     ENSP00000356504   ENSP00000352918   ENSP00000294742  
    Reactome Protein details: O15511

    ARPC5 Human Recombinant Protein Products:

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    Novus Biologicals ARPC5 Proteins
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    ARPC5 Antibody Products:

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    ARPC5 Assay Products:

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    Cloud-Clone Corp. ELISAs for ARPC5
    Cloud-Clone Corp. CLIAs for ARPC5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARPC: Actin related protein 2/3 complex subunits

    1 InterPro protein domain:
     IPR006789 ARP2/3_p16_Arc

    Graphical View of Domain Structure for InterPro Entry O15511

    ProtoNet protein and cluster: O15511

    1 Blocks protein domain: IPB006789 ARP2/3 complex 16 kDa subunit (p16-Arc)

    UniProtKB/Swiss-Prot: ARPC5_HUMAN, O15511
    Similarity: Belongs to the ARPC5 family


    ARPC5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARPC5_HUMAN, O15511
    Function: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and
    together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005200structural constituent of cytoskeleton TAS9230079
    GO:0005515protein binding IPI11162547
         
    ARPC5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ARPC5:
     Decreased focal adhesion (FA)  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARPC5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARPC5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARPC5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARPC5

    miRNA
    Products:
        
    miRTarBase miRNAs that target ARPC5:
    hsa-mir-133a-3p (MIRT021705), hsa-mir-26b-5p (MIRT030269), hsa-mir-30a-5p (MIRT028673), hsa-mir-125a-5p (MIRT021283), hsa-mir-1 (MIRT024056), hsa-mir-10a-5p (MIRT025613), hsa-mir-31-5p (MIRT004981), hsa-mir-22-3p (MIRT006195)

    Block miRNA regulation of human, mouse, rat ARPC5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARPC5 (see all 37):
    hsa-miR-2052 hsa-miR-19b-2* hsa-miR-4328 hsa-miR-4272 hsa-miR-200a hsa-miR-30d hsa-miR-141 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidARPC5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARPC5

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: ARPC5 (NM_005717)
    Sino Biological Human cDNA Clone for ARPC5
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARPC5

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARPC5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARPC5_HUMAN, O15511: Cytoplasm, cytoskeleton. Cell projection
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS9359840
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton ----
    GO:0005885Arp2/3 protein complex TAS9230079
    GO:0015629actin cytoskeleton TAS9230079

    ARPC5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARPC5 About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    Cytoskeleton remodeling Slit Robo signaling0.92
    Neurophysiological process Receptor mediated axon growth repulsion0.41
    Pathogenic Escherichia coli infection0.43
    2Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    3Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils0.51
    4Cell adhesion Integrin mediated cell adhesion and migration
    Cell adhesion Integrin mediated cell adhesion and migration0.49
    Cytoskeleton remodeling Integrin outside in signaling0.37
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    Cytoskeleton remodeling Fibronectin binding integrins in cell motility0.32
    5Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.77
    Fcgamma receptor (FCGR) dependent phagocytosis0.77

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ARPC5
        Salmonella Infection

    Selected GeneGo (Thomson Reuters) Pathways for ARPC5 (see all 14)
        Cytoskeleton remodeling CDC42 in cellular processes
    Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling Integrin outside-in signaling

    Selected BioSystems Pathways for ARPC5 (see all 6)
        Regulation of Actin Cytoskeleton
    B Cell Receptor Signaling Pathway
    Pathogenic Escherichia coli infection
    CDC42 signaling events
    ErbB1 downstream signaling


    1 Reactome Pathway for ARPC5
        Regulation of actin dynamics for phagocytic cup formation


    Selected Kegg Pathways  (Kegg details for ARPC5) (see all 6):
        Fc gamma R-mediated phagocytosis
    Regulation of actin cytoskeleton
    Bacterial invasion of epithelial cells
    Pathogenic Escherichia coli infection
    Shigellosis


    ARPC5 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including ARPC5: 
              Cytoskeleton Regulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ARPC5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARPC5 (O155113 ENSP000003529184) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTR2P611603, ENSP000003672204I2D: score=3 STRING: ENSP00000367220
    MAPKAPK2P491373, ENSP000003560704I2D: score=3 STRING: ENSP00000356070
    ACTR3BQ9P1U13, ENSP000002560014I2D: score=2 STRING: ENSP00000256001
    ARPC1BO151433, ENSP000002527254I2D: score=2 STRING: ENSP00000252725
    EIF3HO153723, ENSP000002766824I2D: score=2 STRING: ENSP00000276682
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement TAS9230079
    GO:0030036actin cytoskeleton organization TAS9359840
    GO:0030833regulation of actin filament polymerization IEA--
    GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS--
    GO:0045087innate immune response TAS--

    ARPC5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARPC5

    2 DrugBank Compounds for ARPC5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one-- --target--10592235
    N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARPC5 gene (2 alternative transcripts): 
    NM_001270439.1  NM_005717.3  

    Unigene Cluster for ARPC5:

    Actin related protein 2/3 complex, subunit 5, 16kDa
    Hs.518609  [show with all ESTs]
    Unigene Representative Sequence: BC034231
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367534 ENST00000462965(uc021pgb.1) ENST00000359856(uc001gql.3)
    ENST00000294742 ENST00000602490
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ARPC5 (see all 37):
    hsa-miR-2052 hsa-miR-19b-2* hsa-miR-4328 hsa-miR-4272 hsa-miR-200a hsa-miR-30d hsa-miR-141 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidARPC5 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat ARPC5

    Additional mRNA sequence: 

    AF006088.1 AF017807.1 AK129598.1 BC034231.1 BC057237.1 

    Selected DOTS entries (see all 25):

    DT.100855250  DT.452009  DT.100664916  DT.100664913  DT.100871584  DT.91987547  DT.100848067  DT.121439947 
    DT.100664917  DT.97860335  DT.95124056  DT.100664903  DT.100664905  DT.95164119  DT.100045599  DT.100676115 
    DT.121439949  DT.121439990  DT.418857  DT.91769832  DT.95164095  DT.95164096  DT.100045609  DT.100649604 

    Selected AceView cDNA sequences (see all 730):

    AW780272 BI859965 AI001040 CD678989 BP372950 BP374299 AW073928 BE463632 
    BQ008261 BQ010364 AA296737 AI439240 CR591569 AI865273 AI148784 BP377129 
    CB108491 AI754981 BF197656 BE044080 AI612735 BP374020 AI628910 AA599091 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ARPC5    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b
    SP1:                    -     -                 -               
    SP2:                    -                       -               
    SP3:                    -     -                                 
    SP4:                                                            


    ECgene alternative splicing isoforms for ARPC5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARPC5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACATCAAAC
    ARPC5 Expression
    About this image


    ARPC5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Thymus (Hematopoietic System)
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    ARPC5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARPC5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.518609
        Pathway & Disease-focused RT2 Profiler PCR Array including ARPC5: 
              Cytoskeleton Regulators in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat ARPC5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARPC5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARPC5 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arpc51 , 5 actin related protein 2/3 complex, subunit 51, 5 91.83(n)1
    99.34(a)1
      1 (65.02 cM)5
    677711  NM_026369.21  NP_080645.21 
     1527665425 
    chicken
    (Gallus gallus)
    Aves ARPC51 actin related protein 2/3 complex, subunit 5, 16kDa 82.78(n)
    95.36(a)
      429075  NM_001031561.1  NP_001026732.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Actin-related protein 2/3 complex subunit 5
    94(a)
    94(a)
    1 ↔ many
    1 ↔ many
    GL343203.1(4048542-4052283)
    AAWZ02037649(3027-15174)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF547300.12   -- 79.73(n)    CF547300.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AY394953.12   -- 77.21(n)    AY394953.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta p16-ARC3
    Arpc51
    actin binding3
    Actin-related protein 2/3 complex, subunit 51
    53(a)3
    58.85(n)1
    53.79(a)1
      23A13
    334441  NM_134849.31  NP_608693.11 
    worm
    (Caenorhabditis elegans)
    Secernentea arx-71 arx-7 50(n)
    42.67(a)
      171882  NM_058698.3  NP_491099.1 


    ENSEMBL Gene Tree for ARPC5 (if available)
    TreeFam Gene Tree for ARPC5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARPC5 gene
    ARPC5L2  
    1 SIMAP similar gene for ARPC5 using alignment to 3 protein entries:     ARPC5_HUMAN (see all proteins):
    ARPC5L

    ARPC5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARPC5 (see all 206)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs75171631,2
    C,F--183594872(+) TAATAC/ACTATT 2 -- ds50016Minor allele frequency- A:0.11NA WA EA 500
    rs1432134081,2
    --183594927(+) GTTTTA/GAAGTG 2 -- ds50010--------
    rs1843549321,2
    --183594987(+) GGTAAA/GTACAA 2 -- ds50010--------
    rs27615741,2
    C,F,O,A--183595037(+) TGGGAG/ATGAAT 2 -- ds500115Minor allele frequency- A:0.35NA EA CSA WA 867
    rs1508698881,2
    --183595042(+) GTGAAC/TGACTG 2 -- ds50010--------
    rs75421361,2
    C,F,A--183595057(+) TGCTAA/GGCTAC 2 -- ds50016Minor allele frequency- G:0.11NA WA EA 496
    rs38561271,2
    C,F,A--183595069(+) TTGCAC/GTTTCT 2 -- ds500111Minor allele frequency- G:0.20NA CSA WA EA 508
    rs75423041,2
    C,F,H--183595180(+) TCATGA/CCTCTC 2 -- ds500117Minor allele frequency- C:0.10NS EA NA WA 2340
    rs1881756021,2
    --183595193(+) CTCTAC/TCATCT 2 -- ds50010--------
    rs1817600541,2
    --183595200(+) ATCTTA/GTATCT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for ARPC5 (183592401 - 183604985 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ARPC5: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARPC5
    DNA2.0 Custom Variant and Variant Library Synthesis for ARPC5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604227    OMIM disorders: --

    6 diseases for ARPC5:    
    About MalaCards
    lung squamous cell carcinoma    shigellosis    congenital hypothyroidism    hypothyroidism
    squamous cell carcinoma    malaria

    1 disease from the University of Copenhagen DISEASES database for ARPC5:
    Congenital hypothyroidism

    ARPC5 for disorders           About GeneDecksing


    Export disorders for ARPC5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARPC5 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with ARPC5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PubMed id 9230079)1, 2, 3 Welch M.D.... Mitchison T.J. (J. Cell Biol. 1997)
    2. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. (PubMed id 9359840)1, 2, 3 Machesky L.M.... Segal A.W. (Biochem. J. 1997)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    6. Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. (PubMed id 11741539)1, 2 Gournier H.... Welch M.D. (Mol. Cell 2001)
    7. Identification of the p16-Arc subunit of the Arp 2/3 complex as a substrate of MAPK-activated protein kinase 2 by proteomic analysis. (PubMed id 12829704)1, 9 Singh S....McLeish K.R. (J. Biol. Chem. 2003)
    8. Identification and characterisation of a novel human isoform of Arp2/3 complex subunit p16-ARC/ARPC5. (PubMed id 12451597)1, 9 Millard T.H....Machesky L.M. (Cell Motil. Cytoskeleton 2003)
    9. Insertions within the actin core of actin-related protein 3 (Arp3) modulate branching nucleation by Arp2/3 complex. (PubMed id 23148219)1 Liu S.L....Nolen B.J. (J. Biol. Chem. 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10092 HGNC: 708 AceView: ARPC5 Ensembl:ENSG00000162704 euGenes: HUgn10092
    ECgene: ARPC5 Kegg: 10092 H-InvDB: ARPC5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARPC5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARPC5 gene:
    Search GeneIP for patents involving ARPC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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