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Aliases for ARPC4-TTLL3 Gene

Aliases for ARPC4-TTLL3 Gene

  • ARPC4-TTLL3 Readthrough 2 3

External Ids for ARPC4-TTLL3 Gene

Previous GeneCards Identifiers for ARPC4-TTLL3 Gene

  • GC03U901686
  • GC03P009838

Summaries for ARPC4-TTLL3 Gene

Entrez Gene Summary for ARPC4-TTLL3 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring ARPC4 (actin related protein 2/3 complex, subunit 4) and TTLL3 (tubulin tyrosine ligase-like family, member 3) genes. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Nov 2010]

GeneCards Summary for ARPC4-TTLL3 Gene

ARPC4-TTLL3 (ARPC4-TTLL3 Readthrough) is a Protein Coding gene. Among its related pathways are CDC42 signaling events and CDC42 signaling events. An important paralog of this gene is TTLL8.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARPC4-TTLL3 Gene

Genomics for ARPC4-TTLL3 Gene

Genomic Location for ARPC4-TTLL3 Gene

Start:
9,792,548 bp from pter
End:
9,836,356 bp from pter
Size:
43,809 bases
Orientation:
Plus strand

Genomic View for ARPC4-TTLL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARPC4-TTLL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPC4-TTLL3 Gene

No data available for Regulatory Elements for ARPC4-TTLL3 Gene

Proteins for ARPC4-TTLL3 Gene

  • Protein details for ARPC4-TTLL3 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0A6YYG9
    Recommended name:
    Protein ARPC4-TTLL3
    Protein Accession:
    A0A0A6YYG9
    Secondary Accessions:

    Protein attributes for ARPC4-TTLL3 Gene

    Size:
    625 amino acids
    Molecular mass:
    71719 Da
    Quaternary structure:
    No Data Available
  • Protein details for ARPC4-TTLL3 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    F8WCF6
    Recommended name:
    Protein ARPC4-TTLL3
    Protein Accession:
    F8WCF6
    Secondary Accessions:

    Protein attributes for ARPC4-TTLL3 Gene

    Size:
    181 amino acids
    Molecular mass:
    21059 Da
    Quaternary structure:
    No Data Available
  • Protein details for ARPC4-TTLL3 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    F8WE39
    Recommended name:
    Protein ARPC4-TTLL3
    Protein Accession:
    F8WE39
    Secondary Accessions:

    Protein attributes for ARPC4-TTLL3 Gene

    Size:
    47 amino acids
    Molecular mass:
    5236 Da
    Quaternary structure:
    No Data Available
  • Protein details for ARPC4-TTLL3 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H7C0A3
    Recommended name:
    Protein ARPC4-TTLL3
    Protein Accession:
    H7C0A3
    Secondary Accessions:

    Protein attributes for ARPC4-TTLL3 Gene

    Size:
    167 amino acids
    Molecular mass:
    19400 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARPC4-TTLL3 Gene

Proteomics data for ARPC4-TTLL3 Gene at MOPED

Post-translational modifications for ARPC4-TTLL3 Gene

No Post-translational modifications

Other Protein References for ARPC4-TTLL3 Gene

No data available for DME Specific Peptides for ARPC4-TTLL3 Gene

Domains for ARPC4-TTLL3 Gene

Protein Domains for ARPC4-TTLL3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARPC4-TTLL3: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ARPC4-TTLL3 Gene

Function for ARPC4-TTLL3 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ARPC4-TTLL3 Gene

Localization for ARPC4-TTLL3 Gene

Gene Ontology (GO) - Cellular Components for ARPC4-TTLL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005885 Arp2/3 protein complex --
GO:0015629 actin cytoskeleton --
genes like me logo Genes that share ontologies with ARPC4-TTLL3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for ARPC4-TTLL3 Gene

Pathways for ARPC4-TTLL3 Gene

genes like me logo Genes that share pathways with ARPC4-TTLL3: view

Pathways by source for ARPC4-TTLL3 Gene

3 BioSystems pathways for ARPC4-TTLL3 Gene

Interacting Proteins for ARPC4-TTLL3 Gene

Gene Ontology (GO) - Biological Process for ARPC4-TTLL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process --
GO:0030041 actin filament polymerization --
GO:0034314 Arp2/3 complex-mediated actin nucleation --
genes like me logo Genes that share ontologies with ARPC4-TTLL3: view

Transcripts for ARPC4-TTLL3 Gene

mRNA/cDNA for ARPC4-TTLL3 Gene

(1) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ARPC4-TTLL3 Gene

No ASD Table

Relevant External Links for ARPC4-TTLL3 Gene

GeneLoc Exon Structure for
ARPC4-TTLL3
ECgene alternative splicing isoforms for
ARPC4-TTLL3

Expression for ARPC4-TTLL3 Gene

mRNA expression in normal human tissues for ARPC4-TTLL3 Gene

Integrated Proteomics: protein expression from PaxDb for ARPC4-TTLL3 Gene

genes like me logo Genes that share expressions with ARPC4-TTLL3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARPC4-TTLL3 Gene

Orthologs for ARPC4-TTLL3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARPC4-TTLL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 62 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 53 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 52 (a)
OneToMany
TTLL3 35
  • 88.68 (n)
  • 91.22 (a)
mouse
(Mus musculus)
Mammalia Ttll3 36
  • 46 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 35 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 39 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 31 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ttll3 36
  • 34 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta TTLL3A 36
  • 20 (a)
ManyToMany
TTLL3B 36
  • 22 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBY1 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for ARPC4-TTLL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARPC4-TTLL3 Gene

ENSEMBL:
Gene Tree for ARPC4-TTLL3 (if available)
TreeFam:
Gene Tree for ARPC4-TTLL3 (if available)

Paralogs for ARPC4-TTLL3 Gene

Selected SIMAP similar genes for ARPC4-TTLL3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARPC4-TTLL3: view

Variants for ARPC4-TTLL3 Gene

Sequence variations from dbSNP and Humsavar for ARPC4-TTLL3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs35800067 -- 9,807,893(+) GGGCT(G/T)TTGAA intron-variant
rs142667926 -- 9,807,674(+) ATTGG(A/C)TAGTA intron-variant
rs150578434 -- 9,807,679(+) ATAGT(A/G)CTAGA intron-variant
rs192385914 -- 9,807,930(+) CCTTG(C/T)CTTGA intron-variant
rs370027885 -- 9,807,842(+) CTGCT(A/G)CACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARPC4-TTLL3 Gene

Variant ID Type Subtype PubMed ID
nsv834615 CNV Loss 17160897
nsv237238 CNV Loss 16902084
nsv819644 CNV Gain 19587683

Relevant External Links for ARPC4-TTLL3 Gene

HapMap Linkage Disequilibrium report
ARPC4-TTLL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARPC4-TTLL3 Gene

Disorders for ARPC4-TTLL3 Gene

No disorders were found for ARPC4-TTLL3 Gene.

No data available for UniProtKB/Swiss-Prot for ARPC4-TTLL3 Gene

Publications for ARPC4-TTLL3 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for ARPC4-TTLL3 Gene

Sources for ARPC4-TTLL3 Gene

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