ARPC4-TTLL3 Gene
protein-coding GIFtS: 22
GCID: GC03P009838
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ARPC4-TTLL3 readthrough
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Aliases
for ARPC4-TTLL3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ARPC4-TTLL3 Readthrough1 2 | | ARPC4-TTLL3 Fusion Protein2 | | ARPC4-TTLL3 Read-Through Transcript2 |
Export aliases for ARPC4-TTLL3 gene to outside databasesPrevious GC identifer: GC03U901686 |
Summaries
for ARPC4-TTLL3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ARPC4-TTLL3:
This locus represents naturally occurring read-through transcription between the neighboring ARPC4 (actin relatedprotein 2/3 complex, subunit 4) and TTLL3 (tubulin tyrosine ligase-like family, member 3) genes. The read-throughtranscript encodes a fusion protein that shares sequence identity with each individual gene product. (provided byRefSeq, Nov 2010)
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Genomic Views
for ARPC4-TTLL3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ARPC4-TTLL3
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARPC4-TTLL3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARPC4-TTLL3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p Ensembl cytogenetic band: 3p25.3 HGNC cytogenetic band: 3p25.3ARPC4-TTLL3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P009838: view genomic region
(about GC identifiers)
Start:
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9,834,798 bp from pter |
End:
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9,877,085 bp from pter |
Size:
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42,288 bases |
Orientation:
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plus strand |
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Proteins
for ARPC4-TTLL3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/TrEMBL: H7C0A3 (See
protein sequence)Recommended Name: Protein ARPC4-TTLL3 Size: 167 amino acids; 19400 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered aspreliminary dataARPC4-TTLL3 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001185722.1
ENSEMBL proteins: ENSP00000380427 ENSP00000393764
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005856 | cytoskeleton |
-- | -- |
ARPC4-TTLL3 for ontologies About GeneDecksing
ARPC4-TTLL3 Antibody Products:
Assay Products for ARPC4-TTLL3: |
Protein
Domains /
Families
for ARPC4-TTLL3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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ARPC4-TTLL3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry H7C0A3ProtoNet protein and cluster: H7C0A3 |
Function
for ARPC4-TTLL3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARPC4-TTLL3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004835 | tubulin-tyrosine ligase activity |
-- | -- |
ARPC4-TTLL3 for ontologies About GeneDecksing
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Pathways & Interactions
for ARPC4-TTLL3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARPC4-TTLL3
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006464 | cellular protein modification process |
-- | -- | | GO:0030041 | actin filament polymerization |
-- | -- |
ARPC4-TTLL3 for ontologies About GeneDecksing
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Drugs & Compounds
for ARPC4-TTLL3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ARPC4-TTLL3
Search CenterWatch for drugs/clinical trials and news about ARPC4-TTLL3 
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Transcripts
for ARPC4-TTLL3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for ARPC4-TTLL3 gene: NM_001198793.1 2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000397256 ENST00000453882
GeneLoc Exon Structure
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Expression
for ARPC4-TTLL3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARPC4-TTLL3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image SABiosciences Custom PCR Arrays for ARPC4-TTLL3
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat ARPC4-TTLL3 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARPC4-TTLL3 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARPC4-TTLL3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARPC4-TTLL3 |
Orthologs
for ARPC4-TTLL3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for ARPC4-TTLL3 gene from 4/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TTLL31 |
tubulin tyrosine ligase-like family, member 3 |
69.54(n)
68.71(a) |
|
416052 XM_414391.3 XP_414391.3 |
lizard
(Anolis carolinensis) |
Reptilia |
TTLL36 |
-- |
51(a) |
1 → many |
2(191298565-191314384) |
zebrafish
(Danio rerio) |
Actinopterygii |
ttll36 |
tubulin tyrosine ligase-like family, member 3 |
33(a) |
1 → many |
6(40260172-40287060) |
fruit fly
(Drosophila melanogaster) |
Insecta |
TTLL3B6TTLL3A6 |
Tubulin tyrosine ligase-like 3A |
20(a)18(a) |
possible orthologpossible ortholog |
2L(6732866-6736149) 2L(6736449-6740176) |
ENSEMBL Gene Tree for ARPC4-TTLL3 (if available)
TreeFam Gene Tree for ARPC4-TTLL3 (if available) |
Paralogs
for ARPC4-TTLL3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ARPC4-TTLL3 gene
- TTLL102 TTLL42 TTLL32 TTLL12 TTLL52 TTLL112 TTLL92 TTLL72
- TTLL62 TTL2 TTLL82 TTLL22 TTLL132
2 SIMAP similar genes for ARPC4-TTLL3 using alignment to 1 protein entry: H7C0A3_HUMAN:TTLL3 ARPC4
ARPC4-TTLL3 for paralogs About GeneDecksing
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Genomic Variants
for ARPC4-TTLL3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for ARPC4-TTLL3 (9834798 - 9877085 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ARPC4-TTLL3: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for ARPC4-TTLL3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ARPC4-TTLL3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for ARPC4-TTLL3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ARPC4-TTLL3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (2010)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for ARPC4-TTLL3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing ARPC4-TTLL3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing ARPC4-TTLL3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ARPC4-TTLL3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
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About This Section
| Patent Information for ARPC4-TTLL3 gene:
Search GeneIP for patents involving ARPC4-TTLL3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ARPC4-TTLL3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARPC4-TTLL3 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARPC4-TTLL3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARPC4-TTLL3 | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARPC4-TTLL3 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARPC4-TTLL3 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARPC4-TTLL3 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARPC4-TTLL3 |
|  |  |  | | | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARPC4-TTLL3 |
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