Aliases for ARPC4 Gene
External Ids for ARPC4 Gene
Previous GeneCards Identifiers for ARPC4 Gene
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. [provided by RefSeq, Nov 2010]
GeneCards Summary for ARPC4 Gene
ARPC4 (Actin Related Protein 2/3 Complex Subunit 4) is a Protein Coding gene. Among its related pathways are Bacterial invasion of epithelial cells and Regulation of actin dynamics for phagocytic cup formation. GO annotations related to this gene include enzyme binding and structural constituent of cytoskeleton.
UniProtKB/Swiss-Prot for ARPC4 Gene
Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.