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Aliases for ARPC4 Gene

Aliases for ARPC4 Gene

  • Actin Related Protein 2/3 Complex, Subunit 4, 20kDa 2 3
  • Arp2/3 Protein Complex Subunit P20 2 3
  • Arp2/3 Complex 20 KDa Subunit 3 4
  • P20-ARC 3 4
  • ARC20 3 4
  • Actin Related Protein 2/3 Complex, Subunit 4 (20 KD) 2
  • Actin-Related Protein 2/3 Complex Subunit 4 3
  • Actin Related Protein 2/3 Complex 2
  • Subunit 4 (20 KD) 2

External Ids for ARPC4 Gene

Previous GeneCards Identifiers for ARPC4 Gene

  • GC03P009763
  • GC03P009826
  • GC03P009809
  • GC03P009750
  • GC03P009834
  • GC03P009775

Summaries for ARPC4 Gene

Entrez Gene Summary for ARPC4 Gene

  • This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. [provided by RefSeq, Nov 2010]

GeneCards Summary for ARPC4 Gene

ARPC4 (Actin Related Protein 2/3 Complex, Subunit 4, 20kDa) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and Immune response CCR3 signaling in eosinophils. GO annotations related to this gene include actin filament binding and protein binding, bridging.

UniProtKB/Swiss-Prot for ARPC4 Gene

  • Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament

Gene Wiki entry for ARPC4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARPC4 Gene

Genomics for ARPC4 Gene

Regulatory Elements for ARPC4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARPC4 Gene

Start:
9,792,495 bp from pter
End:
9,807,726 bp from pter
Size:
15,232 bases
Orientation:
Plus strand

Genomic View for ARPC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARPC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPC4 Gene

Proteins for ARPC4 Gene

  • Protein details for ARPC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59998-ARPC4_HUMAN
    Recommended name:
    Actin-related protein 2/3 complex subunit 4
    Protein Accession:
    P59998
    Secondary Accessions:
    • C9JWM7
    • E7ETI0
    • F6TTL5
    • O15509
    • Q6P0W5
    • Q96QJ3

    Protein attributes for ARPC4 Gene

    Size:
    168 amino acids
    Molecular mass:
    19667 Da
    Quaternary structure:
    • Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC
    SequenceCaution:
    • Sequence=AAH12596.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARPC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARPC4 Gene

Proteomics data for ARPC4 Gene at MOPED

Post-translational modifications for ARPC4 Gene

  • Ubiquitination at Lys44
  • Modification sites at PhosphoSitePlus

Other Protein References for ARPC4 Gene

No data available for DME Specific Peptides for ARPC4 Gene

Domains for ARPC4 Gene

Gene Families for ARPC4 Gene

HGNC:
  • ARPC :Actin related protein 2/3 complex subunits

Protein Domains for ARPC4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ARPC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59998

UniProtKB/Swiss-Prot:

ARPC4_HUMAN :
  • P59998
Family:
  • Belongs to the ARPC4 family.
genes like me logo Genes that share domains with ARPC4: view

Function for ARPC4 Gene

Molecular function for ARPC4 Gene

UniProtKB/Swiss-Prot Function: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament

Gene Ontology (GO) - Molecular Function for ARPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton IDA 11741539
GO:0005515 protein binding IPI 11162547
GO:0019899 enzyme binding IPI 23921388
GO:0030674 contributes_to protein binding, bridging IPI 11162547
GO:0051015 contributes_to actin filament binding NAS 11162547
genes like me logo Genes that share ontologies with ARPC4: view
genes like me logo Genes that share phenotypes with ARPC4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ARPC4 Gene

Localization for ARPC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARPC4 Gene

Cytoplasm, cytoskeleton. Cell projection.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARPC4 Gene COMPARTMENTS Subcellular localization image for ARPC4 gene
Compartment Confidence
cytoskeleton 4
mitochondrion 2
peroxisome 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ARPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005885 Arp2/3 protein complex IDA 11162547
GO:0015629 actin cytoskeleton --
GO:0042995 cell projection IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ARPC4: view

Pathways for ARPC4 Gene

genes like me logo Genes that share pathways with ARPC4: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ARPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007411 axon guidance TAS --
GO:0030041 actin filament polymerization IEA --
GO:0034314 Arp2/3 complex-mediated actin nucleation IDA 11741539
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
genes like me logo Genes that share ontologies with ARPC4: view

Transcripts for ARPC4 Gene

Unigene Clusters for ARPC4 Gene

Actin related protein 2/3 complex, subunit 4, 20kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARPC4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARPC4 Gene

No ASD Table

Relevant External Links for ARPC4 Gene

GeneLoc Exon Structure for
ARPC4
ECgene alternative splicing isoforms for
ARPC4

Expression for ARPC4 Gene

mRNA expression in normal human tissues for ARPC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARPC4 Gene

This gene is overexpressed in Whole Blood (7.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARPC4 Gene

SOURCE GeneReport for Unigene cluster for ARPC4 Gene Hs.323342

genes like me logo Genes that share expressions with ARPC4: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ARPC4 Gene

Orthologs for ARPC4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARPC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARPC4 35
  • 99.82 (n)
  • 100 (a)
ARPC4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARPC4 35
  • 94.25 (n)
  • 99.4 (a)
ARPC4 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARPC4 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arpc4 35
  • 92.06 (n)
  • 99.4 (a)
Arpc4 16
Arpc4 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARPC4 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARPC4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arpc4 35
  • 92.46 (n)
  • 99.4 (a)
chicken
(Gallus gallus)
Aves ARPC4 35
  • 85.12 (n)
  • 98.21 (a)
ARPC4 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARPC4 36
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24361 35
tropical clawed frog
(Silurana tropicalis)
Amphibia arpc4 35
  • 82.54 (n)
  • 98.21 (a)
zebrafish
(Danio rerio)
Actinopterygii arpc4 35
  • 83.53 (n)
  • 97.62 (a)
arpc4 36
  • 87 (a)
OneToMany
arpc4l 36
  • 98 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001306 35
  • 75 (n)
  • 86.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta Arc-p20 36
  • 82 (a)
OneToOne
Arpc4 35
  • 71.83 (n)
  • 82.14 (a)
CG5972 37
  • 82 (a)
worm
(Caenorhabditis elegans)
Secernentea arx-6 35
  • 66.27 (n)
  • 76.79 (a)
arx-6 36
  • 76 (a)
OneToOne
C35D10.16 37
  • 77 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL092C 35
  • 63.07 (n)
  • 68.26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARC19 35
  • 60.08 (n)
  • 68.86 (a)
ARC19 36
  • 67 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E18217g 35
  • 62.67 (n)
  • 68.86 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ARPC4 35
  • 60.81 (n)
  • 65.45 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.3712 35
corn
(Zea mays)
Liliopsida Zm.12074 35
rice
(Oryza sativa)
Liliopsida Os.16908 35
Os03g0848300 35
  • 66.06 (n)
  • 69.09 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01918 35
  • 65.08 (n)
  • 72.02 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arc4 35
  • 60.52 (n)
  • 67.86 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6747 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6209 36
  • 85 (a)
OneToOne
Species with no ortholog for ARPC4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARPC4 Gene

ENSEMBL:
Gene Tree for ARPC4 (if available)
TreeFam:
Gene Tree for ARPC4 (if available)

Paralogs for ARPC4 Gene

Selected SIMAP similar genes for ARPC4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ARPC4: view

No data available for Paralogs for ARPC4 Gene

Variants for ARPC4 Gene

Structural Variations from Database of Genomic Variants (DGV) for ARPC4 Gene

Variant ID Type Subtype PubMed ID
nsv834615 CNV Loss 17160897

Relevant External Links for ARPC4 Gene

HapMap Linkage Disequilibrium report
ARPC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for ARPC4 Gene

Disorders for ARPC4 Gene

No disorders were found for ARPC4 Gene.

No data available for UniProtKB/Swiss-Prot for ARPC4 Gene

Publications for ARPC4 Gene

  1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PMID: 9230079) Welch M.D. … Mitchison T.J. (J. Cell Biol. 1997) 2 3 4
  2. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. (PMID: 9359840) Machesky L.M. … Segal A.W. (Biochem. J. 1997) 2 3 4
  3. Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. (PMID: 11741539) Gournier H. … Welch M.D. (Mol. Cell 2001) 3 4
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4
  5. An actin-filament-binding interface on the Arp2/3 complex is critical for nucleation and branch stability. (PMID: 20404198) Goley E.D. … Welch M.D. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 23

Products for ARPC4 Gene

Sources for ARPC4 Gene

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