Aliases for ARPC4 Gene
External Ids for ARPC4 Gene
Previous GeneCards Identifiers for ARPC4 Gene
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. [provided by RefSeq, Nov 2010]
GeneCards Summary for ARPC4 Gene
ARPC4 (Actin Related Protein 2/3 Complex Subunit 4) is a Protein Coding gene. Among its related pathways are Bacterial invasion of epithelial cells and Endocytosis. GO annotations related to this gene include enzyme binding and structural constituent of cytoskeleton.
UniProtKB/Swiss-Prot for ARPC4 Gene
Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.