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Aliases for ARPC4 Gene

Aliases for ARPC4 Gene

  • Actin Related Protein 2/3 Complex Subunit 4 2 3 5
  • Actin Related Protein 2/3 Complex, Subunit 4 (20 KD) 2 2
  • Arp2/3 Protein Complex Subunit P20 2 3
  • Arp2/3 Complex 20 KDa Subunit 3 4
  • P20-ARC 3 4
  • ARC20 3 4
  • Actin Related Protein 2/3 Complex, Subunit 4, 20kDa 3
  • Actin Related Protein 2/3 Complex Subunit 4, 20kDa 2
  • Actin-Related Protein 2/3 Complex Subunit 4 3

External Ids for ARPC4 Gene

Previous GeneCards Identifiers for ARPC4 Gene

  • GC03P009763
  • GC03P009826
  • GC03P009809
  • GC03P009750
  • GC03P009834
  • GC03P009775

Summaries for ARPC4 Gene

Entrez Gene Summary for ARPC4 Gene

  • This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. [provided by RefSeq, Nov 2010]

GeneCards Summary for ARPC4 Gene

ARPC4 (Actin Related Protein 2/3 Complex Subunit 4) is a Protein Coding gene. Among its related pathways are Immune System and Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include enzyme binding and structural constituent of cytoskeleton.

UniProtKB/Swiss-Prot for ARPC4 Gene

  • Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.

Gene Wiki entry for ARPC4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARPC4 Gene

Genomics for ARPC4 Gene

Regulatory Elements for ARPC4 Gene

Enhancers for ARPC4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F010201 1 FANTOM5 Ensembl ENCODE 14 +412.0 412027 6.7 HDGF PKNOX1 ARNT MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRAK2 TATDN2 VHL GHRLOS ARPC4 FANCD2OS GHRL SEC13 CAMK1 ARPC4-TTLL3
GH03F009861 1.1 FANTOM5 Ensembl ENCODE 12.2 +71.2 71201 5.0 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF48 ZNF143 KLF13 IL17RC JAGN1 CIDEC TADA3 IL17RE ARPC4 RNU6-882P TTLL3 ARPC4-TTLL3 CAMK1
GH03F009870 0.2 ENCODE 10.4 +78.7 78671 1.1 HDAC1 ATF1 PKNOX1 ARNT FEZF1 RAD21 YY1 ZNF121 GATA2 SCRT2 JAGN1 IL17RE RPUSD3 IL17RC RNU6-882P TTLL3 FANCD2 ARPC4 ARPC4-TTLL3 TADA3
GH03F009896 0.8 Ensembl ENCODE 10.3 +107.7 107713 8.2 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YBX1 YY1 SLC30A9 CBX5 RAD18 THUMPD3-AS1 IL17RC GHRLOS JAGN1 ENSG00000269982 CRELD1 PRRT3-AS1 CYCSP10 FANCD2
GH03F009975 0.5 Ensembl ENCODE 10.1 +185.7 185719 4.8 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A ZNF2 FOS KLF13 SMARCB1 THUMPD3-AS1 FANCD2 ENSG00000269894 BRK1 PRRT3 CIDECP IL17RE RPUSD3 VHL JAGN1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ARPC4 on UCSC Golden Path with GeneCards custom track

Promoters for ARPC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001357009 605 2601 HDGF ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1

Genomic Location for ARPC4 Gene

Chromosome:
3
Start:
9,792,495 bp from pter
End:
9,807,726 bp from pter
Size:
15,232 bases
Orientation:
Plus strand

Genomic View for ARPC4 Gene

Genes around ARPC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARPC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARPC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPC4 Gene

Proteins for ARPC4 Gene

  • Protein details for ARPC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59998-ARPC4_HUMAN
    Recommended name:
    Actin-related protein 2/3 complex subunit 4
    Protein Accession:
    P59998
    Secondary Accessions:
    • C9JWM7
    • E7ETI0
    • F6TTL5
    • O15509
    • Q6P0W5
    • Q96QJ3

    Protein attributes for ARPC4 Gene

    Size:
    168 amino acids
    Molecular mass:
    19667 Da
    Quaternary structure:
    • Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.
    SequenceCaution:
    • Sequence=AAH12596.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARPC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARPC4 Gene

Post-translational modifications for ARPC4 Gene

  • Ubiquitination at Lys 44
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARPC4 Gene

Domains & Families for ARPC4 Gene

Gene Families for ARPC4 Gene

Protein Domains for ARPC4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ARPC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59998

UniProtKB/Swiss-Prot:

ARPC4_HUMAN :
  • Belongs to the ARPC4 family.
Family:
  • Belongs to the ARPC4 family.
genes like me logo Genes that share domains with ARPC4: view

Function for ARPC4 Gene

Molecular function for ARPC4 Gene

UniProtKB/Swiss-Prot Function:
Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.

Gene Ontology (GO) - Molecular Function for ARPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton IDA 11741539
GO:0005515 protein binding IPI 11162547
GO:0019899 enzyme binding IPI 23921388
GO:0030674 contributes_to protein binding, bridging IPI 11162547
GO:0051015 contributes_to actin filament binding NAS,IDA 11162547
genes like me logo Genes that share ontologies with ARPC4: view
genes like me logo Genes that share phenotypes with ARPC4: view

Animal Models for ARPC4 Gene

MGI Knock Outs for ARPC4:

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARPC4 Gene

Localization for ARPC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARPC4 Gene

Cytoplasm, cytoskeleton. Cell projection.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARPC4 Gene COMPARTMENTS Subcellular localization image for ARPC4 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
cytosol 4

Gene Ontology (GO) - Cellular Components for ARPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005885 Arp2/3 protein complex IDA 9230079
GO:0015629 actin cytoskeleton IEA --
genes like me logo Genes that share ontologies with ARPC4: view

Pathways & Interactions for ARPC4 Gene

genes like me logo Genes that share pathways with ARPC4: view

Gene Ontology (GO) - Biological Process for ARPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030041 actin filament polymerization IEA --
GO:0034314 Arp2/3 complex-mediated actin nucleation IDA 11741539
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0045010 actin nucleation NAS 11162547
GO:0048013 ephrin receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with ARPC4: view

No data available for SIGNOR curated interactions for ARPC4 Gene

Drugs & Compounds for ARPC4 Gene

(2) Drugs for ARPC4 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one Experimental Pharma Target 0
N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide Experimental Pharma Target 0
genes like me logo Genes that share compounds with ARPC4: view

Transcripts for ARPC4 Gene

Unigene Clusters for ARPC4 Gene

Actin related protein 2/3 complex, subunit 4, 20kDa:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARPC4 Gene

No ASD Table

Relevant External Links for ARPC4 Gene

GeneLoc Exon Structure for
ARPC4
ECgene alternative splicing isoforms for
ARPC4

Expression for ARPC4 Gene

mRNA expression in normal human tissues for ARPC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARPC4 Gene

This gene is overexpressed in Whole Blood (x7.3).

Protein differential expression in normal tissues from HIPED for ARPC4 Gene

This gene is overexpressed in NK cells (10.1) and Tlymphocyte (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARPC4 Gene



Protein tissue co-expression partners for ARPC4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARPC4 Gene:

ARPC4

SOURCE GeneReport for Unigene cluster for ARPC4 Gene:

Hs.323342
genes like me logo Genes that share expression patterns with ARPC4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ARPC4 Gene

Orthologs for ARPC4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARPC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARPC4 34 35
  • 99.82 (n)
dog
(Canis familiaris)
Mammalia ARPC4 35
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARPC4 35
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARPC4 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARPC4 34 35
  • 94.25 (n)
rat
(Rattus norvegicus)
Mammalia Arpc4 34
  • 92.46 (n)
mouse
(Mus musculus)
Mammalia Arpc4 34 16 35
  • 92.06 (n)
chicken
(Gallus gallus)
Aves ARPC4 34 35
  • 85.12 (n)
lizard
(Anolis carolinensis)
Reptilia ARPC4 35
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arpc4 34
  • 82.54 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24361 34
zebrafish
(Danio rerio)
Actinopterygii arpc4l 35
  • 98 (a)
OneToMany
arpc4 34 35
  • 83.53 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5972 36
  • 82 (a)
Arc-p20 35
  • 82 (a)
OneToOne
Arpc4 34
  • 71.83 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001306 34
  • 75 (n)
worm
(Caenorhabditis elegans)
Secernentea C35D10.16 36
  • 77 (a)
arx-6 34 35
  • 66.27 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL092C 34
  • 63.07 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E18217g 34
  • 62.67 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARC19 34 35
  • 60.08 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ARPC4 34
  • 60.81 (n)
rice
(Oryza sativa)
Liliopsida Os03g0848300 34
  • 66.06 (n)
Os.16908 34
barley
(Hordeum vulgare)
Liliopsida Hv.3712 34
corn
(Zea mays)
Liliopsida Zm.12074 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6209 35
  • 85 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU01918 34
  • 65.08 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arc4 34
  • 60.52 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6747 34
Species where no ortholog for ARPC4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARPC4 Gene

ENSEMBL:
Gene Tree for ARPC4 (if available)
TreeFam:
Gene Tree for ARPC4 (if available)

Paralogs for ARPC4 Gene

(1) SIMAP similar genes for ARPC4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ARPC4: view

No data available for Paralogs for ARPC4 Gene

Variants for ARPC4 Gene

Sequence variations from dbSNP and Humsavar for ARPC4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1056428 -- 9,806,641(+) TTCTC(C/G/T)CCTAT intron-variant, utr-variant-3-prime
rs1056460 -- 9,806,852(+) CAAAA(A/G)CCGGG intron-variant, utr-variant-3-prime
rs1056470 -- 9,806,864(+) AACCT(C/T)TGGCT intron-variant, utr-variant-3-prime
rs1056494 -- 9,806,947(+) TGCCA(A/G)AGGTG intron-variant, utr-variant-3-prime
rs1056502 -- 9,806,976(+) AGCTT(C/T)CTGGC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ARPC4 Gene

Variant ID Type Subtype PubMed ID
nsv1010768 CNV gain 25217958
nsv834615 CNV loss 17160897

Variation tolerance for ARPC4 Gene

Residual Variation Intolerance Score: 42.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARPC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARPC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARPC4 Gene

Disorders for ARPC4 Gene

Relevant External Links for ARPC4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARPC4

No disorders were found for ARPC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARPC4 Gene

Publications for ARPC4 Gene

  1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PMID: 9230079) Welch M.D. … Mitchison T.J. (J. Cell Biol. 1997) 2 3 4 64
  2. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. (PMID: 9359840) Machesky L.M. … Segal A.W. (Biochem. J. 1997) 2 3 4 64
  3. An actin-filament-binding interface on the Arp2/3 complex is critical for nucleation and branch stability. (PMID: 20404198) Goley E.D. … Welch M.D. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4 64

Products for ARPC4 Gene

Sources for ARPC4 Gene

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