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ARPC4 Gene

protein-coding   GIFtS: 59
GCID: GC03P009834

Actin Related Protein 2/3 Complex, Subunit 4, 20kDa

(Previous names: actin related protein 2/3 complex, subunit 4 (20 kD))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Actin Related Protein 2/3 Complex, Subunit 4, 20kDa1 2     Actin Related Protein 2/3 Complex, Subunit 4 (20 KD)1
Arp2/3 Protein Complex Subunit P201 2     Subunit 4 (20 KD)1
Arp2/3 Complex 20 KDa Subunit2 3     P20-ARC2
ARC202 3     Actin-Related Protein 2/3 Complex Subunit 42
Actin Related Protein 2/3 Complex1     p20-ARC3

External Ids:    HGNC: 7071   Entrez Gene: 100932   Ensembl: ENSG000002415537   OMIM: 6042265   UniProtKB: P599983   

Export aliases for ARPC4 gene to outside databases

Previous GC identifers: GC03P009763 GC03P009826 GC03P009809 GC03P009750 GC03P009775


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARPC4 Gene:
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin
polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20
subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing
results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene
and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a
fusion protein. (provided by RefSeq, Nov 2010)

GeneCards Summary for ARPC4 Gene:
ARPC4 (actin related protein 2/3 complex, subunit 4, 20kDa) is a protein-coding gene. Diseases associated with ARPC4 include shigellosis, and malaria. GO annotations related to this gene include actin filament binding and protein binding, bridging.

UniProtKB/Swiss-Prot: ARPC4_HUMAN, P59998
Function: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin
polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of
branched actin networks. Seems to contact the mother actin filament

Gene Wiki entry for ARPC4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARPC4 gene promoter:
         NF-1   CREB   HEN1   POU2F1   E2F-1   E2F   deltaCREB   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ARPC4 promoter sequence
   Search Chromatin IP Primers for ARPC4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARPC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.3   Ensembl cytogenetic band:  3p25.3   HGNC cytogenetic band: 3p25

ARPC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARPC4 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P009834:  view genomic region     (about GC identifiers)

Start:
9,834,179 bp from pter      End:
9,849,410 bp from pter
Size:
15,232 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ARPC4_HUMAN, P59998 (See protein sequence)
Recommended Name: Actin-related protein 2/3 complex subunit 4  
Size: 168 amino acids; 19667 Da
Subunit: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC,
ARPC4/p20-ARC and ARPC5/p16-ARC
Sequence caution: Sequence=AAH12596.3; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: C9JWM7 E7ETI0 F6TTL5 O15509 Q6P0W5 Q96QJ3
Alternative splicing: 4 isoforms:  P59998-1   P59998-2   P59998-3   P59998-4   (No experimental confirmation available. Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for ARPC4: NX_P59998

Explore proteomics data for ARPC4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys44
  • Modification sites at PhosphoSitePlus

  • See ARPC4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001020130.1  NP_001020131.1  NP_001185709.1  NP_005709.1  

    ENSEMBL proteins: 
     ENSP00000432235   ENSP00000380431   ENSP00000414751   ENSP00000395085   ENSP00000473435  
     ENSP00000388169   ENSP00000287613  
    Reactome Protein details: P59998

    ARPC4 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARPC: Actin related protein 2/3 complex subunits

    1 InterPro protein domain:
     IPR008384 ARPC4

    Graphical View of Domain Structure for InterPro Entry P59998

    ProtoNet protein and cluster: P59998

    1 Blocks protein domain: IPB008384 ARP23 complex 20 kDa subunit

    UniProtKB/Swiss-Prot: ARPC4_HUMAN, P59998
    Similarity: Belongs to the ARPC4 family


    ARPC4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARPC4_HUMAN, P59998
    Function: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin
    polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of
    branched actin networks. Seems to contact the mother actin filament

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11162547
    GO:0030674contributes to protein binding, bridging IPI11162547
    GO:0051015contributes to actin filament binding NAS11162547
         
    ARPC4 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ARPC4:
     Decreased focal adhesion (FA)   Increased cilium length after   Increased gamma-H2AX phosphory 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Arpc4):
     hematopoietic system  homeostasis/metabolism  integument  mortality/aging 

    ARPC4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARPC4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARPC4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARPC4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARPC4

    miRNA
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    Block miRNA regulation of human, mouse, rat ARPC4 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate ARPC4:
    hsa-miR-498 hsa-miR-149 hsa-miR-3199 hsa-miR-186* hsa-miR-155* hsa-miR-486-3p hsa-miR-621 hsa-miR-4294
    SwitchGear 3'UTR luciferase reporter plasmidARPC4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ARPC4
    Predesigned siRNA for gene silencing in human, mouse, rat ARPC4

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): ARPC4 (NM_001024959)
    Sino Biological Human cDNA Clone for ARPC4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARPC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARPC4

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARPC4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARPC4_HUMAN, P59998: Cytoplasm, cytoskeleton. Cell projection
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    mitochondrion2
    peroxisome2
    cytosol1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton ----
    GO:0005885Arp2/3 protein complex IDA11162547
    GO:0042995cell projection IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    ARPC4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARPC4 About   (see all 16)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    Cytoskeleton remodeling Slit Robo signaling0.92
    Neurophysiological process Receptor mediated axon growth repulsion0.41
    Pathogenic Escherichia coli infection0.43
    2Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils0.51
    3Cell adhesion Integrin mediated cell adhesion and migration
    Cell adhesion Integrin mediated cell adhesion and migration0.49
    Cytoskeleton remodeling Integrin outside in signaling0.37
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    Cytoskeleton remodeling Fibronectin binding integrins in cell motility0.32
    4Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.77
    Fcgamma receptor (FCGR) dependent phagocytosis0.77
    5G protein signaling RAC1 in cellular process
    G protein signaling RAC1 in cellular process0.37
    Cytoskeleton remodeling CDC42 in cellular processes0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ARPC4
        Salmonella Infection

    Selected GeneGo (Thomson Reuters) Pathways for ARPC4 (see all 14)
        Cytoskeleton remodeling CDC42 in cellular processes
    Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling Integrin outside-in signaling

    5 BioSystems Pathways for ARPC4
        B Cell Receptor Signaling Pathway
    Pathogenic Escherichia coli infection
    CDC42 signaling events
    ErbB1 downstream signaling
    RAC1 signaling pathway


    1 Reactome Pathway for ARPC4
        Regulation of actin dynamics for phagocytic cup formation


    Selected Kegg Pathways  (Kegg details for ARPC4) (see all 6):
        Fc gamma R-mediated phagocytosis
    Regulation of actin cytoskeleton
    Bacterial invasion of epithelial cells
    Pathogenic Escherichia coli infection
    Shigellosis


    ARPC4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including ARPC4: 
              Cytoskeleton Regulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ARPC4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARPC4 (P599983 ENSP000003804314) via UniProtKB, MINT, STRING, and/or I2D (see all 96)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTR3BQ9P1U13, ENSP000002560014I2D: score=9 STRING: ENSP00000256001
    ACTR2P611603, ENSP000003672204I2D: score=8 STRING: ENSP00000367220
    ARPC1AQ927473, ENSP000002629424I2D: score=6 STRING: ENSP00000262942
    ARPC5LQ9BPX53, ENSP000002594774I2D: score=4 STRING: ENSP00000259477
    CAP2P401233, ENSP000002299224I2D: score=4 STRING: ENSP00000229922
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030041actin filament polymerization IEA--
    GO:0034314Arp2/3 complex-mediated actin nucleation IEA--
    GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS--
    GO:0045010actin nucleation NAS11162547
    GO:0045087innate immune response TAS--

    ARPC4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARPC4

    2 DrugBank Compounds for ARPC4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one-- --target--10592235
    N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARPC4 gene (4 alternative transcripts): 
    NM_001024959.2  NM_001024960.2  NM_001198780.1  NM_005718.4  

    Unigene Cluster for ARPC4:

    Actin related protein 2/3 complex, subunit 4, 20kDa
    Hs.323342  [show with all ESTs]
    Unigene Representative Sequence: NM_001198793
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000498623 ENST00000397261(uc003btb.2 uc003bsz.2 uc021wsu.1)
    ENST00000479956 ENST00000417500 ENST00000440787 ENST00000467289 ENST00000485273
    ENST00000433034 ENST00000287613(uc003bta.2)
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate ARPC4:
    hsa-miR-498 hsa-miR-149 hsa-miR-3199 hsa-miR-186* hsa-miR-155* hsa-miR-486-3p hsa-miR-621 hsa-miR-4294
    SwitchGear 3'UTR luciferase reporter plasmidARPC4 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 4): ARPC4 (NM_001024959)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARPC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARPC4
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      QuantiFast Probe-based Assays in human, mouse, rat ARPC4

    Additional mRNA sequence: 

    AF006087.1 AF019888.1 BC012596.2 BC065423.1 

    Selected DOTS entries (see all 34):

    DT.92024454  DT.100839921  DT.100722357  DT.449750  DT.100879166  DT.100879150  DT.416860  DT.100721303 
    DT.100839926  DT.100879158  DT.120858139  DT.100839923  DT.97777847  DT.100879163  DT.100879164  DT.120858333 
    DT.99955319  DT.100038728  DT.100692232  DT.120858329  DT.100764756  DT.95267306  DT.97769339  DT.100702847 

    Selected AceView cDNA sequences (see all 645):

    BF589817 BQ932885 BM547583 BC009479 BQ055336 BM808570 BM547859 CD390116 
    BU620751 BX440587 AW517150 BU621249 CR603965 CR609085 AA366815 BP338685 
    CA495316 BM927852 BX425210 AI612891 CD108822 BX431542 AA577831 CA495372 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARPC4 expression in normal human tissues (normalized intensities)      ARPC4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTAGGACCT
    ARPC4 Expression
    About this image


    ARPC4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Negative 2 Thymocytes Thymus
    ARPC4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARPC4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.323342
        Pathway & Disease-focused RT2 Profiler PCR Array including ARPC4: 
              Cytoskeleton Regulators in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for ARPC4
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    QuantiFast Probe-based Assays in human, mouse, rat ARPC4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARPC4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARPC4 gene from Selected species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arpc41 , 5 actin related protein 2/3 complex, subunit 41, 5 92.06(n)1
    99.4(a)1
      6 (52.76 cM)5
    680891  NM_026552.31  NP_080828.11 
     1133781155 
    chicken
    (Gallus gallus)
    Aves ARPC41 actin related protein 2/3 complex, subunit 4, 20kDa 85.12(n)
    98.21(a)
      416051  NM_001257284.1  NP_001244213.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARPC46
    actin related protein 2/3 complex, subunit 4, 20kD...
    97(a)
    1 ↔ 1
    2(191275011-191284232)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.243612 Xenopus laevis transcribed sequence with strong similarity more 82.82(n)    CB197650.2 
    zebrafish
    (Danio rerio)
    Actinopterygii arpc42 actin related protein 2/3 complex, subunit 4 84.12(n)   114456  CD758497.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG59723
    Arpc41
    actin binding3
    Actin-related protein 2/3 complex, subunit 41
    82(a)3
    71.83(n)1
    82.14(a)1
      338641  NM_135152.41  NP_608996.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C35D10.163
    arx-61
    arx-61 77(a)3
    66.27(n)1
    76.79(a)1
      III(4950452-4951191)3
    1756501  NM_065619.41  NP_498020.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARC19(YKL013C)4
    ARC191
    Subunit of the ARP2/3 complex, which is required for more4
    ARC191
    60.08(n)1
    68.86(a)1
      11(418023-417508)4
    8538561, 4  NP_012912.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ARPC41 ARPC4 60.81(n)
    65.45(a)
      3770404  NM_001036555.2  NP_001031632.1 
    rice
    (Oryza sativa)
    Liliopsida Os.169082 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 71.26(n)    AK059137.1 


    ENSEMBL Gene Tree for ARPC4 (if available)
    TreeFam Gene Tree for ARPC4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARPC4 gene
    1 SIMAP similar gene for ARPC4 using alignment to 4 protein entries:     ARPC4_HUMAN (see all proteins):
    ARPC4-TTLL3

    ARPC4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ARPC4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834615CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARPC4
    DNA2.0 Custom Variant and Variant Library Synthesis for ARPC4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604226    OMIM disorders: --

    4 diseases for ARPC4:    About MalaCards
    shigellosis    malaria    pancreatic cancer    pancreatitis


    ARPC4 for disorders           About GeneDecksing


    Export disorders for ARPC4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARPC4 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with ARPC4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PubMed id 9230079)1, 2, 3 Welch M.D.... Mitchison T.J. (J. Cell Biol. 1997)
    2. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. (PubMed id 9359840)1, 2, 3 Machesky L.M.... Segal A.W. (Biochem. J. 1997)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    5. Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. (PubMed id 11741539)1, 2 Gournier H.... Welch M.D. (Mol. Cell 2001)
    6. An actin-filament-binding interface on the Arp2/3 complex is critical for nucleation and branch stability. (PubMed id 20404198)1, 9 Goley E.D....Welch M.D. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    7. Insertions within the actin core of actin-related protein 3 (Arp3) modulate branching nucleation by Arp2/3 complex. (PubMed id 23148219)1 Liu S.L....Nolen B.J. (J. Biol. Chem. 2013)
    8. Expression of the ARPC4 subunit of human Arp2/3 severely affects mycobacterium tuberculosis growth and suppresses immunogenic response in murine macrophages. (PubMed id 23894563)1 Ghosh A....Ranganathan A. (PLoS ONE 2013)
    9. Silencing of the ARP2/3 complex disturbs pancreatic cancer cell migration. (PubMed id 23267127)1 Rauhala H.E....Kallioniemi A. (Anticancer Res. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10093 HGNC: 707 AceView: ARPC4andTTLL3 Ensembl:ENSG00000241553 euGenes: HUgn10093
    ECgene: ARPC4 Kegg: 10093 H-InvDB: ARPC4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ARPC4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARPC4 gene:
    Search GeneIP for patents involving ARPC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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