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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARPC3 Gene

protein-coding   GIFtS: 61
GCID: GC12M110872

actin related protein 2/3 complex, subunit 3, 21kDa

(Previous names: actin related protein 2/3 complex, subunit 3 (21 kD) )
 Explore 3 diseases affiliated with
ARPC3 via our new
 Human Malady Compendium 
Biological research products
for ARPC3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Actin Related Protein 2/3 Complex, Subunit 3, 21kDa1 2     Actin Related Protein 2/3 Complex, Subunit 3 (21 KD)1
ARC211 2 3     Actin-Related Protein 2/3 Complex Subunit 32
P21-Arc1     ARP2/3 Protein Complex Subunit P212
Arp2/3 Complex 21 KDa Subunit2 3     P21-ARC1

External Ids:    HGNC: 7061   Entrez Gene: 100942   Ensembl: ENSG000001112297   OMIM: 6042255   UniProtKB: O151453   

Export aliases for ARPC3 gene to outside databases

Previous GC identifers: GC12M109896 GC12M110668 GC12M110714 GC12M109284 GC12M109335 GC12M107890


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARPC3:
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been
implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of
the protein encoded by this gene, the p21 subunit, has yet to be determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ARPC3_HUMAN, O15145
Function: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and
together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks

Gene Wiki entry for ARPC3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009775.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARPC3 gene promoter:
         GR   NRSF form 1   AP-4   AP-2gamma   c-Ets-1   E2F-1   E2F   GR-alpha   MRF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARPC3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARPC3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARPC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.11   Ensembl cytogenetic band:  12q24.11   HGNC cytogenetic band: 12q24

ARPC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARPC3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M110872:  view genomic region     (about GC identifiers)

Start:
110,872,630 bp from pter      End:
110,888,227 bp from pter
Size:
15,598 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ARPC3_HUMAN, O15145 (See protein sequence)
Recommended Name: Actin-related protein 2/3 complex subunit 3  
Size: 178 amino acids; 20547 Da
Subunit: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC,
ARPC4/p20-ARC and ARPC5/p16-ARC
Subcellular location: Cytoplasm, cytoskeleton. Cell projection
Secondary accessions: O00554

Explore the universe of human proteins at neXtProt for ARPC3: NX_O15145

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15145

  • ARPC3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005710.1  
    ENSEMBL proteins: 
     ENSP00000228825   ENSP00000413221   ENSP00000446598  
    Reactome Protein details: O15145
    Human Recombinant Protein Products: 
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    Uscn Proteins for ARPC3

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton ----
    GO:0005885Arp2/3 protein complex TAS9230079
    GO:0015629actin cytoskeleton TAS9230079
    GO:0030027lamellipodium IEA--


    ARPC3 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ARPC3 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007204 ARP2/3_p21-Arc

    Graphical View of Domain Structure for InterPro Entry O15145

    ProtoNet protein and cluster: O15145

    1 Blocks protein family: IPB007204 ARP2/3 complex

    UniProtKB/Swiss-Prot: ARPC3_HUMAN, O15145
    Similarity: Belongs to the ARPC3 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ARPC3_HUMAN, O15145
    Function: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and
    together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks

         Genatlas biochemistry entry for ARPC3:
    actin related protein 2/3 complex,subunit 3 (21kDa),localized to the lamellipodia of stationary and locomoting
    fibroblasts,inducing actin polymerization and potentially participating in lamellipodial protrusion

    miRNA
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    hsa-miR-3163 hsa-miR-493*
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARPC3

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005200structural constituent of cytoskeleton TAS9230079
    GO:0005515protein binding IPI11162547


    ARPC3 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for ARPC3:
     Decreased focal adhesion (FA)   Increased cell death HMECs cel  Synthetic lethal with Ras  Synthetic lethal with c-Myc af 

    Animal Models:
         Mouse knock-out Arpc3tm1Jtak for ARPC3
         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Arpc3):
     cellular  embryogenesis  growth/size  homeostasis/metabolism  mortality/aging 

    ARPC3 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/19 super-pathways (see all 19About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell adhesion_Integrin-mediated cell adhesion and migration
    Cell adhesion_Integrin-mediated cell adhesion and migration1.00
    Cytoskeleton remodeling_Integrin outside-in signaling0.37
    Cell adhesion Integrin-mediated cell adhesion and migration1.00
    Cytoskeleton remodeling Integrin outside-in signaling0.37
    Cytoskeleton remodeling_Regulation of actin cytoskeleton by Rho GTPases0.49
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility0.32
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    Cytoskeleton remodeling_Fibronectin-binding integrins in cell motility0.32
    2G-protein signaling_RAC1 in cellular process
    G-protein signaling_RAC1 in cellular process1.00
    Cytoskeleton remodeling CDC42 in cellular processes0.37
    G-protein signaling RAC1 in cellular process1.00
    RAC1 signaling pathway0.34
    Cytoskeleton remodeling_CDC42 in cellular processes0.37
    CDC42 signaling events0.17
    3Regulation of actin dynamics for phagocytic cup formation
    Regulation of actin dynamics for phagocytic cup formation1.00
    Fcgamma receptor (FCGR) dependent phagocytosis0.80
    Role of myosins in phagosome formation0.80
    Branching and elongation of mother and daughter filaments0.29
    4Cytoskeleton remodeling Slit-Robo signaling
    Cytoskeleton remodeling Slit-Robo signaling1.00
    Cell adhesion_Cadherin-mediated cell adhesion0.28
    Development_Slit-Robo signaling0.92
    Cell adhesion Cadherin-mediated cell adhesion0.28
    5Immune response CD16 signaling in NK cells
    Immune response CD16 signaling in NK cells1.00
    Immune response_Role of DAP12 receptors in NK cells0.32
    Immune response_CD16 signaling in NK cells0.99
    Immune response Role of DAP12 receptors in NK cells0.32

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/13 EMD Millipore Pathways for ARPC3 (see all 13)
        Cytoskeleton remodeling Integrin outside-in signaling
    Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling CDC42 in cellular processes
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Immune response Role of DAP12 receptors in NK cells

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ARPC3
        BRCA1 Pathway
    DNA Repair Mechanisms
    Salmonella Infection

    5/14 GeneGo (Thomson Reuters) Pathways for ARPC3 (see all 14)
        Cytoskeleton remodeling CDC42 in cellular processes
    Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling Integrin outside-in signaling

    5 BioSystems Pathways for ARPC3 
        B Cell Receptor Signaling Pathway
    Pathogenic Escherichia coli infection
    CDC42 signaling events
    RAC1 signaling pathway
    ErbB1 downstream signaling

    5/6        Reactome Pathways for ARPC3 (see all 6)
        Role of myosins in phagosome formation
    Branching and elongation of mother and daughter filaments
    Regulation of actin dynamics for phagocytic cup formation
    Fcgamma receptor (FCGR) dependent phagocytosis
    Immune System


    5         Kegg Pathways  (Kegg details for ARPC3):
        Fc gamma R-mediated phagocytosis
    Regulation of actin cytoskeleton
    Bacterial invasion of epithelial cells
    Pathogenic Escherichia coli infection
    Shigellosis


    ARPC3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARPC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/175 Interacting proteins for ARPC3 (O151452, 3 ENSP000002288254) via UniProtKB, MINT, STRING, and/or I2D (see all 175)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement TAS9230079
    GO:0030833regulation of actin filament polymerization IEA--


    ARPC3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARPC3

    2 DrugBank Compounds for ARPC3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one-- --target--10592235
    N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about ARPC3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARPC3 gene: 
    NM_005719.2  

    Unigene Cluster for ARPC3:

    Actin related protein 2/3 complex, subunit 3, 21kDa
    Hs.524741  [show with all ESTs]
    Unigene Representative Sequence: BU943983
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000228825(uc001tqq.3) ENST00000488941 ENST00000467622 ENST00000426440
    ENST00000476566 ENST00000547365 ENST00000548878 ENST00000471641 ENST00000475777
    ENST00000549408

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    Additional cDNA sequence: 

    AF004561.1 AF006086.1 AK297309.1 AK311789.1 AL357196.1 BC067747.1 BC078162.1 CR407667.1 
    DQ328220.1 

    24/28 DOTS entries (see all 28):

    DT.95290197  DT.100666390  DT.95162379  DT.97862620  DT.100666385  DT.95162376  DT.121216052  DT.100666386 
    DT.121216159  DT.120690346  DT.121216120  DT.92453362  DT.121216080  DT.100666384  DT.92453363  DT.86859893 
    DT.95162377  DT.92453385  DT.92453365  DT.92453380  DT.95208892  DT.121216092  DT.121216104  DT.121216216 

    24/983 AceView cDNA sequences (see all 983):

    AI130955 AA593738 BQ230788 BM840260 BM783382 BU786140 R23930 BF109961 
    CB240918 BG574858 BQ005152 T30859 CD674462 BQ882141 CD246073 BQ071452 
    AI373621 AV654736 AI203712 BC002941 BM825147 BQ893969 BM503327 BM781474 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ARPC3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                      -                           
    SP2:                    -                 -                           
    SP3:                    -     -                                       


    ECgene alternative splicing isoforms for ARPC3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARPC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTTTACTTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ARPC3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARPC3

    SOURCE GeneReport for Unigene cluster: Hs.524741
        SABiosciences Expression via Pathway-Focused PCR Array including ARPC3: 
              Cytoskeleton Regulators in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARPC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARPC3 gene from 10/34 species (see all 34)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arpc31 , 5 actin related protein 2/3 complex, subunit 31, 5 86.7(n)1
    97.75(a)1
      5 (62.34 cM)5
    563781  NM_019824.31  NP_062798.11 
     1223918785 
    chicken
    (Gallus gallus)
    Aves ARPC31 actin related protein 2/3 complex, subunit 3, 21kDa 83.71(n)
    94.94(a)
      416837  XM_415128.3  XP_415128.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARPC36
    --
    90(a)
    1 ↔ 1
    LGb(2151687-2153991)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC056034.12   -- 80.51(n)    BC056034.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gng32 Transcribed sequence with moderate similarity to protein more 79.52(n)    57091539 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG89363
    Arpc3B1
    actin filament organization actin binding3
    Arpc3B1
    60(a)
    (best of 2)3
    61.46(n)1
    61.85(a)1
      15E33
    326961  NM_132965.21  NP_573193.11 
    worm
    (Caenorhabditis elegans)
    Secernentea arx-51 Protein ARX-5 59.05(n)
    55.43(a)
      176697  NM_067266.2  NP_499667.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARC18(YLR370C)4
    ARC181
    Subunit of the ARP2/3 complex, which is required for more4
    Arc18p1
    52.99(n)1
    47.4(a)1
      12(862254-861718)4
    8510851, 4  NP_013474.31  NP_013474.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ARPC31 actin-related protein C3 53.54(n)
    49.09(a)
      842338  NM_104730.2  NP_564757.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g02350001 hypothetical protein 53.17(n)
    47.93(a)
      4328824  NM_001052919.2  NP_001046384.2 


    ENSEMBL Gene Tree for ARPC3 (if available)
    TreeFam Gene Tree for ARPC3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARPC3 gene

    ARPC3 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for ARPC3
    PGOHUM00000242364 PGOHUM00000242431 PGOHUM00000245198 PGOHUM00000247668 PGOHUM00000243491


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/268 NCBI SNPs in ARPC3 are shown (see all 268    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1888613871,2
    --110872227(+) ACAGGC/TGTGAT 1 -- ds50010--------
    rs110656381,2
    C,F,H,--110872240(+) ACTGCG/ACCTGG 1 -- ds500112Minor allele frequency- A:0.01NS EA NA 1762
    rs1155853331,2
    F,--110872320(+) TGATAT/CATGCT 1 -- ds50011Minor allele frequency- C:0.05WA 118
    rs558331461,2
    C,F,--110872335(+) CATGGA/GTGAAT 1 -- ds50015Minor allele frequency- G:0.22WA CSA NA 244
    rs1414604231,2
    --110872590(+) CTTCAC/TGTATA 1 -- ds50010--------
    rs1854451811,2
    --110872605(+) AAAAAA/TAGTGA 1 -- ds50010--------
    rs792464571,2
    --110872607(+) AAAAAG/CTGAAT 1 -- ds50011Minor allele frequency- C:0.01EA 120
    rs140741,2
    C--110872766(-) TTTCTG/TCAGCA 1 -- ut31 ese32Minor allele frequency- T:0.00NA 4
    rs1452778821,2
    --110872823(+) TTCTTC/GATCAA 1 -- ut310--------
    rs1476368121,2
    --110872864(+) TCTTCG/TGTATA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ARPC3 (110872630 - 110888227 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ARPC3: --
    Human Gene Mutation Database (HGMD): ARPC3

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARPC3
    DNA2.0 Custom Variant and Variant Library Synthesis for ARPC3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ARPC3 for disorders           About GeneDecksing

    OMIM gene information: 604225    OMIM disorders: --

    3 diseases for ARPC3:    About MalaCards
    wiskott-aldrich syndrome    shigellosis    keratosis


    Export disorders for ARPC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARPC3 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with ARPC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PubMed id 9230079)1, 2, 3 Welch M.D.... Mitchison T.J. (1997)
    2. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. (PubMed id 9359840)1, 2, 3 Machesky L.M.... Segal A.W. (1997)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    5. Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. (PubMed id 11741539)1, 2 Gournier H.... Welch M.D. (2001)
    6. Insertions within the actin core of actin-related prot ein 3 (Arp3) modulate branching nucleation by Arp2/3 complex. (PubMed id 23148219)1 Liu S.L....Nolen B.J. (2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10094 HGNC: 706 AceView: ARPC3andANAPC7 Ensembl:ENSG00000111229 euGenes: HUgn10094
    ECgene: ARPC3 Kegg: 10094 H-InvDB: ARPC3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARPC3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARPC3 gene:
    Search GeneIP for patents involving ARPC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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