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Aliases for ARPC3 Gene

Aliases for ARPC3 Gene

  • Actin Related Protein 2/3 Complex Subunit 3 2 3 5
  • Arp2/3 Complex 21 KDa Subunit 3 4
  • P21-Arc 3 4
  • ARC21 3 4
  • Actin Related Protein 2/3 Complex, Subunit 3 (21 KD) 2
  • Actin Related Protein 2/3 Complex, Subunit 3, 21kDa 3
  • Actin Related Protein 2/3 Complex Subunit 3, 21kDa 2
  • Actin-Related Protein 2/3 Complex Subunit 3 3
  • ARP2/3 Protein Complex Subunit P21 3

External Ids for ARPC3 Gene

Previous GeneCards Identifiers for ARPC3 Gene

  • GC12M109896
  • GC12M110668
  • GC12M110714
  • GC12M109284
  • GC12M109335
  • GC12M110872
  • GC12M107890

Summaries for ARPC3 Gene

Entrez Gene Summary for ARPC3 Gene

  • This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

GeneCards Summary for ARPC3 Gene

ARPC3 (Actin Related Protein 2/3 Complex Subunit 3) is a Protein Coding gene. Among its related pathways are BRCA1 Pathway and Immune response CCR3 signaling in eosinophils. GO annotations related to this gene include actin filament binding and structural constituent of cytoskeleton.

UniProtKB/Swiss-Prot for ARPC3 Gene

  • Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

Gene Wiki entry for ARPC3 Gene

Additional gene information for ARPC3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARPC3 Gene

Genomics for ARPC3 Gene

Regulatory Elements for ARPC3 Gene

Enhancers for ARPC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H110078 1.9 FANTOM5 Ensembl ENCODE dbSUPER 22.9 +370.8 370784 1 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B DMAP1 YY1 ZNF766 CBX5 ARPC3 IFT81 RNU4-32P ALKBH2 UBE3B C12orf76 RAD9B GIT2 GC12P110058
GH12H110574 1.9 FANTOM5 Ensembl ENCODE dbSUPER 18.5 -126.8 -126755 6 HDGF PKNOX1 FOXA2 MLX ARID4B DMAP1 YBX1 YY1 ZNF766 ZNF207 FAM216A GPN3 ARPC3 TCTN1 GLTP PPTC7 ATP2A2 VPS29
GH12H110269 1.5 Ensembl ENCODE dbSUPER 22.3 +180.2 180230 2 FOXA2 ATF1 SIN3A FEZF1 TCF12 GATA2 ATF7 FOS DEK SMARCA4 ARPC3 C12orf76 FAM216A GLTP GC12P110274 GC12P110258
GH12H110536 1.4 Ensembl ENCODE dbSUPER 23.6 -87.6 -87599 2 INSM2 FEZF1 RAD21 YY1 ZNF366 SCRT2 ZNF391 EGR2 ZNF362 TSHZ1 ARPC3 GLTP GPN3 VPS29 PPTC7
GH12H110279 1.4 ENCODE dbSUPER 22.8 +167.6 167602 5 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 GPN3 ARPC3 ANAPC7 IFT81 ATP2A2 GC12M110365 RN7SL769P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARPC3 on UCSC Golden Path with GeneCards custom track

Promoters for ARPC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000057326 422 1601 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for ARPC3 Gene

Chromosome:
12
Start:
110,434,825 bp from pter
End:
110,450,422 bp from pter
Size:
15,598 bases
Orientation:
Minus strand

Genomic View for ARPC3 Gene

Genes around ARPC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARPC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARPC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPC3 Gene

Proteins for ARPC3 Gene

  • Protein details for ARPC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15145-ARPC3_HUMAN
    Recommended name:
    Actin-related protein 2/3 complex subunit 3
    Protein Accession:
    O15145
    Secondary Accessions:
    • O00554

    Protein attributes for ARPC3 Gene

    Size:
    178 amino acids
    Molecular mass:
    20547 Da
    Quaternary structure:
    • Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

neXtProt entry for ARPC3 Gene

Post-translational modifications for ARPC3 Gene

  • Ubiquitination at Lys14, Lys56, posLast=158158, and posLast=171171
  • Modification sites at PhosphoSitePlus

Other Protein References for ARPC3 Gene

No data available for DME Specific Peptides for ARPC3 Gene

Domains & Families for ARPC3 Gene

Gene Families for ARPC3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ARPC3 Gene

Graphical View of Domain Structure for InterPro Entry

O15145

UniProtKB/Swiss-Prot:

ARPC3_HUMAN :
  • Belongs to the ARPC3 family.
Family:
  • Belongs to the ARPC3 family.
genes like me logo Genes that share domains with ARPC3: view

Function for ARPC3 Gene

Molecular function for ARPC3 Gene

GENATLAS Biochemistry:
actin related protein 2/3 complex,subunit 3 (21kDa),localized to the lamellipodia of stationary and locomoting fibroblasts,inducing actin polymerization and potentially participating in lamellipodial protrusion
UniProtKB/Swiss-Prot Function:
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

Phenotypes From GWAS Catalog for ARPC3 Gene

Gene Ontology (GO) - Molecular Function for ARPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton IDA 11741539
GO:0005515 protein binding IPI 11162547
GO:0051015 contributes_to actin filament binding IDA 11741539
genes like me logo Genes that share ontologies with ARPC3: view
genes like me logo Genes that share phenotypes with ARPC3: view

Animal Models for ARPC3 Gene

MGI Knock Outs for ARPC3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ARPC3
  • Applied Biological Materials Clones for ARPC3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARPC3 Gene

Localization for ARPC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARPC3 Gene

Cytoplasm, cytoskeleton. Cell projection.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARPC3 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
nucleus 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ARPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005885 Arp2/3 protein complex IDA,IEA 11741539
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with ARPC3: view

Pathways & Interactions for ARPC3 Gene

genes like me logo Genes that share pathways with ARPC3: view

Gene Ontology (GO) - Biological Process for ARPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 9230079
GO:0030833 regulation of actin filament polymerization IEA --
GO:0034314 Arp2/3 complex-mediated actin nucleation IDA,IEA 11741539
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0048013 ephrin receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with ARPC3: view

No data available for SIGNOR curated interactions for ARPC3 Gene

Drugs & Compounds for ARPC3 Gene

(3) Drugs for ARPC3 Gene - From: DrugBank and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one Experimental Pharma Target 0
N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide Experimental Pharma Target 0
CK-636 Pharma Arp2/3 complex inhibitor 0

(1) ApexBio Compounds for ARPC3 Gene

Compound Action Cas Number
CK-636 Arp2/3 complex inhibitor 442632-72-6
genes like me logo Genes that share compounds with ARPC3: view

Drug Products

Transcripts for ARPC3 Gene

Unigene Clusters for ARPC3 Gene

Actin related protein 2/3 complex, subunit 3, 21kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ARPC3
  • Applied Biological Materials Clones for ARPC3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ARPC3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: - -
SP3: - -

Relevant External Links for ARPC3 Gene

GeneLoc Exon Structure for
ARPC3
ECgene alternative splicing isoforms for
ARPC3

Expression for ARPC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARPC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARPC3 Gene

This gene is overexpressed in Whole Blood (x6.7).

Protein differential expression in normal tissues from HIPED for ARPC3 Gene

This gene is overexpressed in Tlymphocyte (6.9) and Spleen (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARPC3 Gene



Protein tissue co-expression partners for ARPC3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARPC3 Gene:

ARPC3

SOURCE GeneReport for Unigene cluster for ARPC3 Gene:

Hs.524741

Evidence on tissue expression from TISSUES for ARPC3 Gene

  • Nervous system(4.9)
  • Blood(4.4)
  • Liver(4.4)
  • Skin(4.3)
  • Pancreas(3.9)
  • Lung(3.7)
  • Spleen(2.7)
  • Intestine(2.6)
  • Heart(2.3)
  • Kidney(2.3)
  • Bone marrow(2.1)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with ARPC3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARPC3 Gene

Orthologs for ARPC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARPC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARPC3 33 34
  • 99.63 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 98 (a)
OneToMany
-- 34
  • 97 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ARPC3 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARPC3 33 34
  • 94.76 (n)
dog
(Canis familiaris)
Mammalia ARPC3 33 34
  • 94.76 (n)
rat
(Rattus norvegicus)
Mammalia Arpc3 33
  • 88.39 (n)
mouse
(Mus musculus)
Mammalia Arpc3 33 16 34
  • 86.7 (n)
chicken
(Gallus gallus)
Aves ARPC3 33 34
  • 83.71 (n)
lizard
(Anolis carolinensis)
Reptilia ARPC3 34
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arpc3 33
  • 79.03 (n)
Str.10867 33
zebrafish
(Danio rerio)
Actinopterygii arpc3 33 34
  • 78.46 (n)
gng3 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8941 33
fruit fly
(Drosophila melanogaster)
Insecta Arpc3A 33 34
  • 62.34 (n)
Arpc3B 34
  • 61 (a)
OneToMany
CG8936 35
  • 60 (a)
CG4560 35
  • 59 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001712 33
  • 60.26 (n)
worm
(Caenorhabditis elegans)
Secernentea arx-5 33 34
  • 59.05 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B07821g 33
  • 54.14 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARC18 33 34 36
  • 52.99 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR584C 33
  • 51.06 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ARPC3 33
  • 53.61 (n)
rice
(Oryza sativa)
Liliopsida Os02g0235000 33
  • 52.8 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 60 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arc3 33
  • 55.43 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09572 33
  • 52.6 (n)
Species where no ortholog for ARPC3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARPC3 Gene

ENSEMBL:
Gene Tree for ARPC3 (if available)
TreeFam:
Gene Tree for ARPC3 (if available)

Paralogs for ARPC3 Gene

genes like me logo Genes that share paralogs with ARPC3: view

No data available for Paralogs for ARPC3 Gene

Variants for ARPC3 Gene

Sequence variations from dbSNP and Humsavar for ARPC3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000120781 -- 110,442,375(+) GGCTG(A/C)GGCGG intron-variant
rs1000137416 -- 110,447,591(+) AACAT(C/G)GTGAA intron-variant
rs1000210057 -- 110,447,448(+) TTCTG(G/T)TCCTT intron-variant
rs1000485991 -- 110,441,065(+) GTCTT(C/G)ATCTC intron-variant
rs1000535968 -- 110,445,676(+) GAAGG(A/G)ATAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARPC3 Gene

Variant ID Type Subtype PubMed ID
nsv976651 CNV duplication 23825009

Variation tolerance for ARPC3 Gene

Residual Variation Intolerance Score: 69.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARPC3 Gene

Human Gene Mutation Database (HGMD)
ARPC3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARPC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARPC3 Gene

Disorders for ARPC3 Gene

Relevant External Links for ARPC3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARPC3

No disorders were found for ARPC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARPC3 Gene

Publications for ARPC3 Gene

  1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PMID: 9230079) Welch MD … Mitchison TJ (The Journal of cell biology 1997) 2 3 4 60
  2. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. (PMID: 9359840) Machesky LM … Segal AW (The Biochemical journal 1997) 2 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K … Vandekerckhove J (Nature biotechnology 2003) 3 4 60
  5. Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. (PMID: 11741539) Gournier H … Welch MD (Molecular cell 2001) 3 4 60

Products for ARPC3 Gene

  • Addgene plasmids for ARPC3

Sources for ARPC3 Gene

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