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Aliases for ARPC3 Gene

Aliases for ARPC3 Gene

  • Actin Related Protein 2/3 Complex, Subunit 3, 21kDa 2 3
  • Arp2/3 Complex 21 KDa Subunit 3 4
  • P21-Arc 3 4
  • ARC21 3 4
  • Actin Related Protein 2/3 Complex, Subunit 3 (21 KD) 2
  • Actin-Related Protein 2/3 Complex Subunit 3 3
  • ARP2/3 Protein Complex Subunit P21 3

External Ids for ARPC3 Gene

Summaries for ARPC3 Gene

Entrez Gene Summary for ARPC3 Gene

  • This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

GeneCards Summary for ARPC3 Gene

ARPC3 (Actin Related Protein 2/3 Complex, Subunit 3, 21kDa) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and Immune response CCR3 signaling in eosinophils. GO annotations related to this gene include actin binding and structural constituent of cytoskeleton.

UniProtKB/Swiss-Prot for ARPC3 Gene

  • Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks

Gene Wiki entry for ARPC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARPC3 Gene

Genomics for ARPC3 Gene

Genomic Location for ARPC3 Gene

Start:
110,434,825 bp from pter
End:
110,450,422 bp from pter
Size:
15,598 bases
Orientation:
Minus strand

Genomic View for ARPC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARPC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPC3 Gene

Regulatory Elements for ARPC3 Gene

Proteins for ARPC3 Gene

  • Protein details for ARPC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15145-ARPC3_HUMAN
    Recommended name:
    Actin-related protein 2/3 complex subunit 3
    Protein Accession:
    O15145
    Secondary Accessions:
    • O00554

    Protein attributes for ARPC3 Gene

    Size:
    178 amino acids
    Molecular mass:
    20547 Da
    Quaternary structure:
    • Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

neXtProt entry for ARPC3 Gene

Proteomics data for ARPC3 Gene at MOPED

Post-translational modifications for ARPC3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys14, Lys56, Lys158, and Lys171

Other Protein References for ARPC3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ARPC3 Gene

Domains for ARPC3 Gene

Gene Families for ARPC3 Gene

HGNC:
  • ARPC :Actin related protein 2/3 complex subunits

Protein Domains for ARPC3 Gene

UniProtKB/Swiss-Prot:

ARPC3_HUMAN
Family:
  • Belongs to the ARPC3 family.:
    • O15145
genes like me logo Genes that share domains with ARPC3: view

Function for ARPC3 Gene

Molecular function for ARPC3 Gene

GENATLAS Biochemistry: actin related protein 2/3 complex,subunit 3 (21kDa),localized to the lamellipodia of stationary and locomoting fibroblasts,inducing actin polymerization and potentially participating in lamellipodial protrusion
UniProtKB/Swiss-Prot Function: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks

Gene Ontology (GO) - Molecular Function for ARPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton IDA 11741539
GO:0005515 protein binding IPI 11162547
GO:0051015 contributes_to actin filament binding IDA 11741539
genes like me logo Genes that share ontologies with ARPC3: view
genes like me logo Genes that share phenotypes with ARPC3: view

Animal Models for ARPC3 Gene

MGI Knock Outs for ARPC3:

miRNA for ARPC3 Gene

miRTarBase miRNAs that target ARPC3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ARPC3 Gene

Localization for ARPC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARPC3 Gene

Cytoplasm, cytoskeleton. Cell projection.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARPC3 Gene COMPARTMENTS Subcellular localization image for ARPC3 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ARPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton --
GO:0005885 Arp2/3 protein complex IDA 11741539
GO:0005925 focal adhesion IDA 21423176
GO:0015629 actin cytoskeleton TAS 9230079
genes like me logo Genes that share ontologies with ARPC3: view

Pathways for ARPC3 Gene

genes like me logo Genes that share pathways with ARPC3: view

Gene Ontology (GO) - Biological Process for ARPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 9230079
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007411 axon guidance TAS --
GO:0030833 regulation of actin filament polymerization --
GO:0034314 Arp2/3 complex-mediated actin nucleation IDA 11741539
genes like me logo Genes that share ontologies with ARPC3: view

Transcripts for ARPC3 Gene

Unigene Clusters for ARPC3 Gene

Actin related protein 2/3 complex, subunit 3, 21kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARPC3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: - -
SP3: - -

Relevant External Links for ARPC3 Gene

GeneLoc Exon Structure for
ARPC3
ECgene alternative splicing isoforms for
ARPC3

Expression for ARPC3 Gene

mRNA expression in normal human tissues for ARPC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARPC3 Gene

This gene is overexpressed in Whole Blood (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ARPC3 Gene

SOURCE GeneReport for Unigene cluster for ARPC3 Gene Hs.524741

genes like me logo Genes that share expressions with ARPC3: view

Orthologs for ARPC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARPC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARPC3 36
  • 99.63 (n)
  • 99.44 (a)
ARPC3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARPC3 36
  • 94.76 (n)
  • 100 (a)
ARPC3 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARPC3 36
  • 94.76 (n)
  • 100 (a)
ARPC3 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arpc3 36
  • 86.7 (n)
  • 97.75 (a)
Arpc3 16
Arpc3 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 98 (a)
OneToMany
-- 37
  • 97 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ARPC3 37
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arpc3 36
  • 88.39 (n)
  • 97.75 (a)
chicken
(Gallus gallus)
Aves ARPC3 36
  • 83.71 (n)
  • 94.94 (a)
ARPC3 37
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARPC3 37
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arpc3 36
  • 79.03 (n)
  • 93.26 (a)
Str.10867 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8941 36
zebrafish
(Danio rerio)
Actinopterygii arpc3 36
  • 78.46 (n)
  • 87.08 (a)
arpc3 37
  • 87 (a)
OneToOne
gng3 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001712 36
  • 60.26 (n)
  • 64.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta Arpc3A 36
  • 62.34 (n)
  • 59.89 (a)
Arpc3A 37
  • 59 (a)
OneToMany
Arpc3B 37
  • 61 (a)
OneToMany
CG8936 38
  • 60 (a)
CG4560 38
  • 59 (a)
worm
(Caenorhabditis elegans)
Secernentea arx-5 36
  • 59.05 (n)
  • 55.43 (a)
arx-5 37
  • 52 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR584C 36
  • 51.06 (n)
  • 44.51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARC18 36
  • 52.99 (n)
  • 47.4 (a)
ARC18 37
  • 39 (a)
OneToOne
ARC18 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B07821g 36
  • 54.14 (n)
  • 48.55 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ARPC3 36
  • 53.61 (n)
  • 48.8 (a)
rice
(Oryza sativa)
Liliopsida Os02g0235000 36
  • 52.8 (n)
  • 45.6 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09572 36
  • 52.6 (n)
  • 47.4 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arc3 36
  • 55.43 (n)
  • 53.49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 60 (a)
OneToOne
Species with no ortholog for ARPC3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARPC3 Gene

ENSEMBL:
Gene Tree for ARPC3 (if available)
TreeFam:
Gene Tree for ARPC3 (if available)

Paralogs for ARPC3 Gene

genes like me logo Genes that share paralogs with ARPC3: view

No data available for Paralogs for ARPC3 Gene

Variants for ARPC3 Gene

Sequence variations from dbSNP and Humsavar for ARPC3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs14074 -- 110,434,961(-) TTTCT(G/T)CAGCA utr-variant-3-prime
rs1044490 -- 110,434,950(-) TTAAA(A/G)CTGGC utr-variant-3-prime
rs2339483 -- 110,448,793(+) GGGGG(G/T)GGTGG intron-variant
rs3759382 -- 110,451,678(-) AGTTC(C/T)GTGGA upstream-variant-2KB
rs3759383 -- 110,451,066(-) TTGAT(A/G)TTTCC upstream-variant-2KB

Relevant External Links for ARPC3 Gene

HapMap Linkage Disequilibrium report
ARPC3
Human Gene Mutation Database (HGMD)
ARPC3

No data available for Structural Variations from Database of Genomic Variants (DGV) for ARPC3 Gene

Disorders for ARPC3 Gene

No disorders were found for ARPC3 Gene.

No data available for UniProtKB/Swiss-Prot for ARPC3 Gene

Publications for ARPC3 Gene

  1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PMID: 9230079) Welch M.D. … Mitchison T.J. (J. Cell Biol. 1997) 2 3 4
  2. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. (PMID: 9359840) Machesky L.M. … Segal A.W. (Biochem. J. 1997) 2 3 4
  3. Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. (PMID: 11741539) Gournier H. … Welch M.D. (Mol. Cell 2001) 3 4
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ARPC3 Gene

  • Addgene plasmids for ARPC3

Sources for ARPC3 Gene

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