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ARPC3 Gene

protein-coding   GIFtS: 65
GCID: GC12M110872

Actin Related Protein 2/3 Complex, Subunit 3, 21kDa

(Previous names: actin related protein 2/3 complex, subunit 3 (21 kD))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Actin Related Protein 2/3 Complex, Subunit 3, 21kDa1 2     Actin-Related Protein 2/3 Complex Subunit 32
Arp2/3 Complex 21 KDa Subunit2 3     ARP2/3 Protein Complex Subunit P212
ARC212 3     p21-Arc2
Actin Related Protein 2/3 Complex, Subunit 3 (21 KD)1     p21-ARC3

External Ids:    HGNC: 7061   Entrez Gene: 100942   Ensembl: ENSG000001112297   OMIM: 6042255   UniProtKB: O151453   
ORGUL members:         

Export aliases for ARPC3 gene to outside databases

Previous GC identifers: GC12M109896 GC12M110668 GC12M110714 GC12M109284 GC12M109335 GC12M107890


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARPC3 Gene:
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been
conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively
spliced transcript variants have been found for this gene. (provided by RefSeq, Dec 2013)

GeneCards Summary for ARPC3 Gene:
ARPC3 (actin related protein 2/3 complex, subunit 3, 21kDa) is a protein-coding gene. Diseases associated with ARPC3 include shigellosis, and wiskott-aldrich syndrome. GO annotations related to this gene include actin binding and structural constituent of cytoskeleton.

UniProtKB/Swiss-Prot: ARPC3_HUMAN, O15145
Function: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and
together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks

Gene Wiki entry for ARPC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARPC3 gene promoter:
         GR   NRSF form 1   AP-4   AP-2gamma   c-Ets-1   E2F-1   E2F   GR-alpha   MRF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARPC3 promoter sequence
   Search Chromatin IP Primers for ARPC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARPC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.11   Ensembl cytogenetic band:  12q24.11   HGNC cytogenetic band: 12q24

ARPC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARPC3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M110872:  view genomic region     (about GC identifiers)

Start:
110,872,630 bp from pter      End:
110,888,227 bp from pter
Size:
15,598 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ARPC3_HUMAN, O15145 (See protein sequence)
Recommended Name: Actin-related protein 2/3 complex subunit 3  
Size: 178 amino acids; 20547 Da
Subunit: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC,
ARPC4/p20-ARC and ARPC5/p16-ARC
Secondary accessions: O00554

Explore the universe of human proteins at neXtProt for ARPC3: NX_O15145

Explore proteomics data for ARPC3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys14, Lys56, Lys158, Lys171
  • Modification sites at PhosphoSitePlus

  • See ARPC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001265485.1  NP_001274151.1  

    ENSEMBL proteins: 
     ENSP00000228825   ENSP00000413221   ENSP00000446598  
    Reactome Protein details: O15145

    ARPC3 Human Recombinant Protein Products:

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    ARPC3 Antibody Products:

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    ARPC3 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARPC: Actin related protein 2/3 complex subunits

    1 InterPro protein domain:
     IPR007204 ARP2/3_p21-Arc

    Graphical View of Domain Structure for InterPro Entry O15145

    ProtoNet protein and cluster: O15145

    1 Blocks protein domain: IPB007204 ARP2/3 complex

    UniProtKB/Swiss-Prot: ARPC3_HUMAN, O15145
    Similarity: Belongs to the ARPC3 family


    ARPC3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARPC3_HUMAN, O15145
    Function: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and
    together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks

         Genatlas biochemistry entry for ARPC3:
    actin related protein 2/3 complex,subunit 3 (21kDa),localized to the lamellipodia of stationary and locomoting
    fibroblasts,inducing actin polymerization and potentially participating in lamellipodial protrusion

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005200structural constituent of cytoskeleton TAS9230079
    GO:0005515protein binding IPI11162547
         
    ARPC3 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for ARPC3:
     Decreased focal adhesion (FA)   Increased cell death HMECs cel  Synthetic lethal with Ras  Synthetic lethal with c-Myc af 

         7 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Arpc3):
     behavior/neurological  cellular  embryogenesis  growth/size/body  homeostasis/metabolism 
     mortality/aging  nervous system 

    ARPC3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Arpc3tm1Jtak for ARPC3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARPC3
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARPC3

    miRNA
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    miRTarBase miRNAs that target ARPC3:
    hsa-mir-155-5p (MIRT020984), hsa-mir-25-3p (MIRT050237)

    Block miRNA regulation of human, mouse, rat ARPC3 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate ARPC3:
    hsa-miR-3163 hsa-miR-493*
    SwitchGear 3'UTR luciferase reporter plasmidARPC3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARPC3

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    GenScript: all cDNA clones in your preferred vector: ARPC3 (NM_005719)
    Sino Biological Human cDNA Clone for ARPC3
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    In Situ Assay
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARPC3_HUMAN, O15145: Cytoplasm, cytoskeleton. Cell projection
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton ----
    GO:0005885Arp2/3 protein complex IEA--
    GO:0015629actin cytoskeleton TAS9230079
    GO:0030027lamellipodium IEA--

    ARPC3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARPC3 About   (see all 18)  
    See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    Cytoskeleton remodeling Slit Robo signaling0.92
    Neurophysiological process Receptor mediated axon growth repulsion0.41
    Pathogenic Escherichia coli infection0.43
    2Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils0.51
    3Cell adhesion Integrin mediated cell adhesion and migration
    Cell adhesion Integrin mediated cell adhesion and migration0.49
    Cytoskeleton remodeling Integrin outside in signaling0.37
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    Cytoskeleton remodeling Fibronectin binding integrins in cell motility0.32
    4Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.77
    Fcgamma receptor (FCGR) dependent phagocytosis0.77
    5G protein signaling RAC1 in cellular process
    G protein signaling RAC1 in cellular process0.37
    Cytoskeleton remodeling CDC42 in cellular processes0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ARPC3
        BRCA1 Pathway
    DNA Repair Mechanisms
    Salmonella Infection

    Selected GeneGo (Thomson Reuters) Pathways for ARPC3 (see all 14)
        Cytoskeleton remodeling CDC42 in cellular processes
    Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling Integrin outside-in signaling

    5 BioSystems Pathways for ARPC3
        B Cell Receptor Signaling Pathway
    Pathogenic Escherichia coli infection
    CDC42 signaling events
    ErbB1 downstream signaling
    RAC1 signaling pathway


    1 Reactome Pathway for ARPC3
        Regulation of actin dynamics for phagocytic cup formation


    Selected Kegg Pathways  (Kegg details for ARPC3) (see all 6):
        Fc gamma R-mediated phagocytosis
    Regulation of actin cytoskeleton
    Bacterial invasion of epithelial cells
    Pathogenic Escherichia coli infection
    Shigellosis


    ARPC3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including ARPC3: 
              Cytoskeleton Regulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ARPC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARPC3 (O151452, 3 ENSP000002288254) via UniProtKB, MINT, STRING, and/or I2D (see all 215)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement TAS9230079
    GO:0030833regulation of actin filament polymerization ----
    GO:0034314Arp2/3 complex-mediated actin nucleation IEA--
    GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS--
    GO:0045087innate immune response TAS--

    ARPC3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARPC3

    2 DrugBank Compounds for ARPC3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one-- --target--10592235
    N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARPC3 gene (2 alternative transcripts): 
    NM_001278556.1  NM_001287222.1  

    Unigene Cluster for ARPC3:

    Actin related protein 2/3 complex, subunit 3, 21kDa
    Hs.524741  [show with all ESTs]
    Unigene Representative Sequence: BU943983
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000228825(uc001tqq.3) ENST00000467622 ENST00000426440 ENST00000476566
    ENST00000547365 ENST00000548878 ENST00000471641 ENST00000475777 ENST00000549408

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate ARPC3:
    hsa-miR-3163 hsa-miR-493*
    SwitchGear 3'UTR luciferase reporter plasmidARPC3 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF004561.1 AF006086.1 AK297309.1 AK311789.1 AL357196.1 BC067747.1 BC078162.1 CR407667.1 
    DQ328220.1 

    Selected DOTS entries (see all 28):

    DT.95290197  DT.100666390  DT.95162379  DT.97862620  DT.100666385  DT.95162376  DT.121216052  DT.100666386 
    DT.121216159  DT.120690346  DT.121216120  DT.92453362  DT.121216080  DT.100666384  DT.92453363  DT.86859893 
    DT.95162377  DT.92453385  DT.92453365  DT.92453380  DT.95208892  DT.121216092  DT.121216104  DT.121216216 

    Selected AceView cDNA sequences (see all 983):

    BU579698 BQ306497 BM820404 AI280926 CD370180 BM786709 CR595174 BM090590 
    BI822586 BM090818 BM841042 AI904688 Z38852 CA308584 AI298479 AW087296 
    BM474970 CA310195 BM504981 T33935 BU507226 AA844001 CA426261 CR611961 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ARPC3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                      -                           
    SP2:                    -                 -                           
    SP3:                    -     -                                       


    ECgene alternative splicing isoforms for ARPC3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARPC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTTACTTG
    ARPC3 Expression
    About this image


    ARPC3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    ARPC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARPC3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524741
        Pathway & Disease-focused RT2 Profiler PCR Array including ARPC3: 
              Cytoskeleton Regulators in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARPC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARPC3 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arpc31 , 5 actin related protein 2/3 complex, subunit 31, 5 86.7(n)1
    97.75(a)1
      5 (62.34 cM)5
    563781  NM_019824.31  NP_062798.11 
     1223918785 
    chicken
    (Gallus gallus)
    Aves ARPC31 actin related protein 2/3 complex, subunit 3, 21kDa 83.71(n)
    94.94(a)
      416837  NM_001277486.1  NP_001264415.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARPC36
    actin related protein 2/3 complex, subunit 3, 21kD...
    91(a)
    1 ↔ 1
    LGb(2148701-2154261)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC056034.12   -- 80.51(n)    BC056034.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gng32 Transcribed sequence with moderate similarity to protein more 79.52(n)    57091539 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG89363
    Arpc3A1
    actin filament organization actin
    binding3
    Actin-related protein 2/3 complex, subunit 3A1
    60(a)
    (best of 2)3
    62.34(n)1
    59.89(a)1
      15E33
    419171  NM_142241.21  NP_650498.31 
    worm
    (Caenorhabditis elegans)
    Secernentea arx-51 arx-5 59.05(n)
    55.43(a)
      176697  NM_067266.3  NP_499667.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARC18(YLR370C)4
    ARC181
    Subunit of the ARP2/3 complex, which is required for more4
    ARC181
    52.99(n)1
    47.4(a)1
      12(862254-861718)4
    8510851, 4  NP_013474.31  NP_013474.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ARPC31 ARPC3 53.61(n)
    48.8(a)
      842338  NM_001084274.1  NP_001077743.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g02350001 Os02g0235000 52.8(n)
    45.6(a)
      4328824  NM_001052919.2  NP_001046384.2 


    ENSEMBL Gene Tree for ARPC3 (if available)
    TreeFam Gene Tree for ARPC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARPC3 gene

    ARPC3 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for ARPC3
    PGOHUM00000242364 PGOHUM00000242431 PGOHUM00000245198 PGOHUM00000247668 PGOHUM00000243491


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARPC3 (see all 360)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1888613871,2
    --110872227(+) ACAGGC/TGTGAT 1 -- ds50010--------
    rs110656381,2
    C,F,H--110872240(+) ACTGCG/ACCTGG 1 -- ds500112Minor allele frequency- A:0.01NS EA NA 1762
    rs1155853331,2
    C,F--110872320(+) TGATAT/CATGCT 1 -- ds50011Minor allele frequency- C:0.05WA 118
    rs558331461,2
    C,F--110872335(+) CATGGA/GTGAAT 1 -- ds50015Minor allele frequency- G:0.22WA CSA NA 244
    rs1414604231,2
    --110872590(+) CTTCAC/TGTATA 1 -- ds50010--------
    rs1854451811,2
    --110872605(+) AAAAAA/TAGTGA 1 -- ds50010--------
    rs792464571,2
    F--110872607(+) AAAAAG/CTGAAT 1 -- ds50011Minor allele frequency- C:0.01EA 120
    rs140741,2
    C--110872766(-) TTTCTG/TCAGCA 1 -- ut31 ese32Minor allele frequency- T:0.00NA 4
    rs1452778821,2
    --110872823(+) TTCTTC/GATCAA 1 -- ut310--------
    rs1476368121,2
    --110872864(+) TCTTCG/TGTATA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ARPC3 (110872630 - 110888227 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ARPC3: --
    Human Gene Mutation Database (HGMD): ARPC3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARPC3
    DNA2.0 Custom Variant and Variant Library Synthesis for ARPC3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604225    OMIM disorders: --

    4 diseases for ARPC3:    
    About MalaCards
    shigellosis    wiskott-aldrich syndrome    keratosis    malaria


    ARPC3 for disorders           About GeneDecksing


    Export disorders for ARPC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARPC3 gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with ARPC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PubMed id 9230079)1, 2, 3 Welch M.D.... Mitchison T.J. (J. Cell Biol. 1997)
    2. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. (PubMed id 9359840)1, 2, 3 Machesky L.M.... Segal A.W. (Biochem. J. 1997)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    5. Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. (PubMed id 11741539)1, 2 Gournier H.... Welch M.D. (Mol. Cell 2001)
    6. Insertions within the actin core of actin-related protein 3 (Arp3) modulate branching nucleation by Arp2/3 complex. (PubMed id 23148219)1 Liu S.L....Nolen B.J. (J. Biol. Chem. 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Proteomic analysis of I+4I^1 integrin adhesion complexes reveals I+-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (Proteomics 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10094 HGNC: 706 AceView: ARPC3andANAPC7 Ensembl:ENSG00000111229 euGenes: HUgn10094
    ECgene: ARPC3 Kegg: 10094 H-InvDB: ARPC3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ARPC3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ARPC3 gene:
    Search GeneIP for patents involving ARPC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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