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Aliases for ARPC2 Gene

Aliases for ARPC2 Gene

  • Actin Related Protein 2/3 Complex, Subunit 2, 34kDa 2 3
  • ARC34 3 4 6
  • Arp2/3 Complex 34 KDa Subunit 3 4
  • P34-Arc 3 4
  • Actin Related Protein 2/3 Complex, Subunit 2 (34 KD) 2
  • Actin-Related Protein 2/3 Complex Subunit 2 3
  • ARP2/3 Protein Complex Subunit 34 3
  • PNAS-139 3
  • PRO2446 3

External Ids for ARPC2 Gene

Previous GeneCards Identifiers for ARPC2 Gene

  • GC02P217097
  • GC02P217803
  • GC02P219045
  • GC02P219284
  • GC02P218907
  • GC02P218790
  • GC02P219081
  • GC02P210935

Summaries for ARPC2 Gene

Entrez Gene Summary for ARPC2 Gene

  • This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARPC2 Gene

ARPC2 (Actin Related Protein 2/3 Complex, Subunit 2, 34kDa) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and Immune response CCR3 signaling in eosinophils. GO annotations related to this gene include actin binding and kinesin binding.

UniProtKB/Swiss-Prot for ARPC2 Gene

  • Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament

Gene Wiki entry for ARPC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARPC2 Gene

Genomics for ARPC2 Gene

Regulatory Elements for ARPC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARPC2 Gene

Start:
218,217,094 bp from pter
End:
218,254,356 bp from pter
Size:
37,263 bases
Orientation:
Plus strand

Genomic View for ARPC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARPC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPC2 Gene

Proteins for ARPC2 Gene

  • Protein details for ARPC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15144-ARPC2_HUMAN
    Recommended name:
    Actin-related protein 2/3 complex subunit 2
    Protein Accession:
    O15144
    Secondary Accessions:
    • Q92801
    • Q9P1D4

    Protein attributes for ARPC2 Gene

    Size:
    300 amino acids
    Molecular mass:
    34333 Da
    Quaternary structure:
    • Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.
    SequenceCaution:
    • Sequence=AAC50874.1; Type=Frameshift; Positions=14; Evidence={ECO:0000305}; Sequence=AAF71122.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ARPC2 Gene

Proteomics data for ARPC2 Gene at MOPED

Post-translational modifications for ARPC2 Gene

  • Ubiquitination at Lys65, Lys127, Lys269, Lys275, and Lys295
  • Modification sites at PhosphoSitePlus

Other Protein References for ARPC2 Gene

No data available for DME Specific Peptides for ARPC2 Gene

Domains for ARPC2 Gene

Gene Families for ARPC2 Gene

HGNC:
  • ARPC :Actin related protein 2/3 complex subunits

Protein Domains for ARPC2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O15144

UniProtKB/Swiss-Prot:

ARPC2_HUMAN :
  • O15144
Family:
  • Belongs to the ARPC2 family.
genes like me logo Genes that share domains with ARPC2: view

Function for ARPC2 Gene

Molecular function for ARPC2 Gene

GENATLAS Biochemistry: actin related protein 2/3 complex,subunit 2 (34kDa),localized to the lamellipodia of stationary and locomoting fibroblasts,inducing actin polymerization and potentially participating in lamellipodial protrusion
UniProtKB/Swiss-Prot Function: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament

Gene Ontology (GO) - Molecular Function for ARPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton IDA 11741539
GO:0005515 protein binding IPI 11162547
GO:0019894 kinesin binding IEA --
GO:0035650 AP-1 adaptor complex binding IEA --
GO:0051015 contributes_to actin filament binding IDA 11741539
genes like me logo Genes that share ontologies with ARPC2: view
genes like me logo Genes that share phenotypes with ARPC2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARPC2 Gene

Localization for ARPC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARPC2 Gene

Cytoplasm, cytoskeleton. Cell projection. Cell junction, synapse, synaptosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARPC2 Gene COMPARTMENTS Subcellular localization image for ARPC2 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
golgi apparatus 4
endosome 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ARPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005768 endosome IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton --
genes like me logo Genes that share ontologies with ARPC2: view

Pathways for ARPC2 Gene

genes like me logo Genes that share pathways with ARPC2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ARPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 9230079
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007411 axon guidance TAS --
GO:0010592 positive regulation of lamellipodium assembly IMP 18560548
GO:0030833 regulation of actin filament polymerization --
genes like me logo Genes that share ontologies with ARPC2: view

Transcripts for ARPC2 Gene

Unigene Clusters for ARPC2 Gene

Actin related protein 2/3 complex, subunit 2, 34kDa:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARPC2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARPC2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13
SP1: - - - - - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - -
SP7: -
SP8: - -
SP9:
SP10: - - - - - - - -
SP11: - - - - -
SP12: - - - -

Relevant External Links for ARPC2 Gene

GeneLoc Exon Structure for
ARPC2
ECgene alternative splicing isoforms for
ARPC2

Expression for ARPC2 Gene

mRNA expression in normal human tissues for ARPC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARPC2 Gene

This gene is overexpressed in Whole Blood (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARPC2 Gene

SOURCE GeneReport for Unigene cluster for ARPC2 Gene Hs.529303

genes like me logo Genes that share expressions with ARPC2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ARPC2 Gene

Orthologs for ARPC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARPC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARPC2 35
  • 99.78 (n)
  • 100 (a)
ARPC2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARPC2 35
  • 96.11 (n)
  • 99.67 (a)
ARPC2 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARPC2 35
  • 95.46 (n)
  • 99.28 (a)
ARPC2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arpc2 35
  • 94.22 (n)
  • 99.33 (a)
Arpc2 16
Arpc2 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARPC2 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARPC2 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arpc2 35
  • 94.33 (n)
  • 99.67 (a)
chicken
(Gallus gallus)
Aves ARPC2 35
  • 85.56 (n)
  • 94.67 (a)
ARPC2 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARPC2 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8128 35
tropical clawed frog
(Silurana tropicalis)
Amphibia arpc2 35
  • 78.64 (n)
  • 92.28 (a)
Str.2022 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9084 35
zebrafish
(Danio rerio)
Actinopterygii arpc2 35
  • 76.85 (n)
  • 88.59 (a)
arpc2 36
  • 88 (a)
OneToOne
Dr.26857 35
African malaria mosquito
(Anopheles gambiae)
Insecta ARPC2_ANOGA 35
  • 65.77 (n)
  • 75.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta Arc-p34 36
  • 74 (a)
OneToOne
Arpc2 35
  • 67.12 (n)
  • 75.76 (a)
Arc-p34 37
  • 75 (a)
worm
(Caenorhabditis elegans)
Secernentea arx-4 35
  • 68.23 (n)
  • 70.9 (a)
arx-4 36
  • 70 (a)
OneToOne
Y6D11A.2 37
  • 70 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARC35 36
  • 32 (a)
OneToOne
ARC35 38
thale cress
(Arabidopsis thaliana)
eudicotyledons DIS2 35
  • 41.61 (n)
  • 29.02 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03050 35
  • 56.77 (n)
  • 50.85 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arc2 35
  • 55.21 (n)
  • 50.17 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5746 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10350 36
  • 70 (a)
OneToOne
Species with no ortholog for ARPC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARPC2 Gene

ENSEMBL:
Gene Tree for ARPC2 (if available)
TreeFam:
Gene Tree for ARPC2 (if available)

Paralogs for ARPC2 Gene

No data available for Paralogs for ARPC2 Gene

Variants for ARPC2 Gene

Sequence variations from dbSNP and Humsavar for ARPC2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs11879 -- 218,239,445(+) TTTAA(G/T)GATGA reference, missense
rs13147 -- 218,249,898(+) GCCGA(G/T)AAAAA reference, missense
rs15405 -- 218,234,390(+) AATCC(A/G)GAATC reference, synonymous-codon
rs15406 -- 218,228,832(+) CTTCA(G/T)GCACA reference, missense
rs907981 -- 218,252,434(+) AACCT(A/G)GTCTC intron-variant

Relevant External Links for ARPC2 Gene

HapMap Linkage Disequilibrium report
ARPC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARPC2 Gene

Disorders for ARPC2 Gene

Relevant External Links for ARPC2

Genetic Association Database (GAD)
ARPC2
Human Genome Epidemiology (HuGE) Navigator
ARPC2
genes like me logo Genes that share disorders with ARPC2: view

No data available for UniProtKB/Swiss-Prot for ARPC2 Gene

Publications for ARPC2 Gene

  1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PMID: 9230079) Welch M.D. … Mitchison T.J. (J. Cell Biol. 1997) 2 3 4
  2. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. (PMID: 9359840) Machesky L.M. … Segal A.W. (Biochem. J. 1997) 2 3
  3. Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. (PMID: 11741539) Gournier H. … Welch M.D. (Mol. Cell 2001) 3 4
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ARPC2 Gene

Sources for ARPC2 Gene

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