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ARPC2 Gene

protein-coding   GIFtS: 67
GCID: GC02P219081

Actin Related Protein 2/3 Complex, Subunit 2, 34kDa

(Previous names: actin related protein 2/3 complex, subunit 2 (34 kD))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Actin Related Protein 2/3 Complex, Subunit 2, 34kDa1 2     Actin-Related Protein 2/3 Complex Subunit 22
ARC342 3 5     ARP2/3 Protein Complex Subunit 342
Arp2/3 Complex 34 KDa Subunit2 3     p34-Arc2
Actin Related Protein 2/3 Complex, Subunit 2 (34 KD)1     p34-ARC3
PNAS-1392     

External Ids:    HGNC: 7051   Entrez Gene: 101092   Ensembl: ENSG000001634667   OMIM: 6042245   UniProtKB: O151443   

Export aliases for ARPC2 gene to outside databases

Previous GC identifers: GC02P217097 GC02P217803 GC02P219045 GC02P219284 GC02P218907 GC02P218790 GC02P210935


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARPC2 Gene:
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been
implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact
role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced
variants have been characterized to date. Additional alternatively spliced variants have been described but their
full length nature has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for ARPC2 Gene:
ARPC2 (actin related protein 2/3 complex, subunit 2, 34kDa) is a protein-coding gene. Diseases associated with ARPC2 include diffuse scleroderma, and shigellosis. GO annotations related to this gene include actin binding and kinesin binding.

UniProtKB/Swiss-Prot: ARPC2_HUMAN, O15144
Function: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin
polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of
branched actin networks. Seems to contact the mother actin filament

Gene Wiki entry for ARPC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARPC2 gene promoter:
         FOXF2   RelA   NF-kappaB   NF-kappaB1   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARPC2 promoter sequence
   Search Chromatin IP Primers for ARPC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARPC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.1   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q36.1

ARPC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARPC2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P219081:  view genomic region     (about GC identifiers)

Start:
219,081,817 bp from pter      End:
219,119,079 bp from pter
Size:
37,263 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARPC2_HUMAN, O15144 (See protein sequence)
Recommended Name: Actin-related protein 2/3 complex subunit 2  
Size: 300 amino acids; 34333 Da
Subunit: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC,
ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of
SHANK3 with the Arp2/3 complex
Sequence caution: Sequence=AAC50874.1; Type=Frameshift; Positions=14; Sequence=AAF71122.1; Type=Erroneous
initiation; Note=Translation N-terminally extended;
Secondary accessions: Q92801 Q9P1D4

Explore the universe of human proteins at neXtProt for ARPC2: NX_O15144

Explore proteomics data for ARPC2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys65, Lys127, Lys269, Lys275, Lys295
  • Modification sites at PhosphoSitePlus

  • See ARPC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_005722.1  NP_690601.1  

    ENSEMBL proteins: 
     ENSP00000327137   ENSP00000401070   ENSP00000396475   ENSP00000412632   ENSP00000295685  
     ENSP00000411612  
    Reactome Protein details: O15144

    ARPC2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARPC: Actin related protein 2/3 complex subunits

    1 InterPro protein domain:
     IPR007188 P34-arc

    Graphical View of Domain Structure for InterPro Entry O15144

    ProtoNet protein and cluster: O15144

    1 Blocks protein domain: IPB007188 Arp2/3 complex

    UniProtKB/Swiss-Prot: ARPC2_HUMAN, O15144
    Similarity: Belongs to the ARPC2 family


    ARPC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARPC2_HUMAN, O15144
    Function: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin
    polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of
    branched actin networks. Seems to contact the mother actin filament

         Genatlas biochemistry entry for ARPC2:
    actin related protein 2/3 complex,subunit 2 (34kDa),localized to the lamellipodia of stationary and locomoting
    fibroblasts,inducing actin polymerization and potentially participating in lamellipodial protrusion

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005200structural constituent of cytoskeleton TAS9230079
    GO:0005515protein binding IPI11162547
    GO:0019894kinesin binding IEA--
    GO:0035650AP-1 adaptor complex binding IEA--
         
    ARPC2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ARPC2:
     Decreased focal adhesion (FA)   Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Arpc2):
     adipose tissue  growth/size/body  homeostasis/metabolism  integument  mortality/aging 
     skeleton 

    ARPC2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARPC2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARPC2
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    miRNA
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    miRTarBase miRNAs that target ARPC2:
    hsa-mir-93-5p (MIRT048830), hsa-mir-149-5p (MIRT045659), hsa-mir-17-5p (MIRT050988), hsa-mir-20a-5p (MIRT050616), hsa-mir-92a-3p (MIRT049237)

    Block miRNA regulation of human, mouse, rat ARPC2 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate ARPC2:
    hsa-miR-1184 hsa-miR-544 hsa-miR-891b hsa-miR-518a-5p hsa-miR-548b-3p hsa-miR-888 hsa-miR-1205
    SwitchGear 3'UTR luciferase reporter plasmidARPC2 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for ARPC2
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARPC2_HUMAN, O15144: Cytoplasm, cytoskeleton. Cell projection. Cell junction, synapse, synaptosome (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    golgi apparatus4
    endosome2
    nucleus2
    plasma membrane2

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005768endosome IEA--
    GO:0005794Golgi apparatus IDA--
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton ----

    ARPC2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARPC2 About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    Cytoskeleton remodeling Slit Robo signaling0.92
    Neurophysiological process Receptor mediated axon growth repulsion0.41
    Pathogenic Escherichia coli infection0.43
    2Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils0.51
    3Cell adhesion Integrin mediated cell adhesion and migration
    Cell adhesion Integrin mediated cell adhesion and migration0.49
    Cytoskeleton remodeling Integrin outside in signaling0.37
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    Cytoskeleton remodeling Fibronectin binding integrins in cell motility0.32
    4Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.77
    Fcgamma receptor (FCGR) dependent phagocytosis0.77
    5G protein signaling RAC1 in cellular process
    G protein signaling RAC1 in cellular process0.37
    Cytoskeleton remodeling CDC42 in cellular processes0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected GeneGo (Thomson Reuters) Pathways for ARPC2 (see all 14)
        Cytoskeleton remodeling CDC42 in cellular processes
    Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling Integrin outside-in signaling

    5 BioSystems Pathways for ARPC2
        B Cell Receptor Signaling Pathway
    Pathogenic Escherichia coli infection
    CDC42 signaling events
    ErbB1 downstream signaling
    RAC1 signaling pathway


    1 Reactome Pathway for ARPC2
        Regulation of actin dynamics for phagocytic cup formation


    Selected Kegg Pathways  (Kegg details for ARPC2) (see all 6):
        Fc gamma R-mediated phagocytosis
    Regulation of actin cytoskeleton
    Bacterial invasion of epithelial cells
    Pathogenic Escherichia coli infection
    Shigellosis


    ARPC2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including ARPC2: 
              Cytoskeleton Regulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ARPC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARPC2 (O151441, 2, 3 ENSP000002956854) via UniProtKB, MINT, STRING, and/or I2D (see all 194)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=3 STRING: ENSP00000349467
    CALM2P621583, ENSP000002722984I2D: score=3 STRING: ENSP00000272298
    CALM3P621583, ENSP000002912954I2D: score=3 STRING: ENSP00000291295
    CORO1BQ9BR761, 3, ENSP000003402114EBI-352356,EBI-351152 I2D: score=3 STRING: ENSP00000340211
    ARPC1AQ927473, ENSP000002629424I2D: score=6 STRING: ENSP00000262942
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement TAS9230079
    GO:0010592positive regulation of lamellipodium assembly IMP18560548
    GO:0030833regulation of actin filament polymerization ----
    GO:0030838positive regulation of actin filament polymerization IEA--
    GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS--

    ARPC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for ARPC2

    2 DrugBank Compounds for ARPC2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one-- --target--10592235
    N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARPC2 gene (2 alternative transcripts): 
    NM_005731.3  NM_152862.2  

    Unigene Cluster for ARPC2:

    Actin related protein 2/3 complex, subunit 2, 34kDa
    Hs.529303  [show with all ESTs]
    Unigene Representative Sequence: BF240734
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000315717(uc002vhd.3) ENST00000420104 ENST00000489598 ENST00000491780
    ENST00000420201 ENST00000478612 ENST00000480062 ENST00000414983 ENST00000295685(uc002vhe.3)
    ENST00000465395 ENST00000471355 ENST00000472753 ENST00000484961 ENST00000470146
    ENST00000477992(uc002vhf.3) ENST00000462034 ENST00000456575 ENST00000487321

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    hsa-miR-1184 hsa-miR-544 hsa-miR-891b hsa-miR-518a-5p hsa-miR-548b-3p hsa-miR-888 hsa-miR-1205
    SwitchGear 3'UTR luciferase reporter plasmidARPC2 3' UTR sequence
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    Additional mRNA sequence: 

    AF006085.1 AF279893.1 AK290268.1 BC000590.2 BT006898.1 U50523.1 

    Selected DOTS entries (see all 39):

    DT.97856683  DT.100801439  DT.91780855  DT.95260472  DT.100801444  DT.100801440  DT.103135  DT.100869812 
    DT.100869813  DT.120982542  DT.320157  DT.97760165  DT.95260449  DT.100039611  DT.120982521  DT.95318670 
    DT.100869814  DT.100869818  DT.120982493  DT.120982558  DT.320161  DT.91938977  DT.95284481  DT.97766961 

    Selected AceView cDNA sequences (see all 865):

    BM911689 BE276652 BG575409 AA586851 AA188712 BX396762 BM758099 N57236 
    W93488 AI184556 BG030134 AI760217 AW327851 BQ671712 N35362 AW328357 
    AI718730 CB157871 BM967364 CB138036 CF127757 AI304484 AI348449 BQ019643 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARPC2 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13
    SP1:        -     -                             -     -     -                       -     -                                         -         
    SP2:                                                                                -     -                                         -         
    SP3:                                            -     -     -                       -     -                                                   
    SP4:                                      -     -     -     -                       -     -                                                   
    SP5:        -     -                                   -     -                                                                                 


    ECgene alternative splicing isoforms for ARPC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARPC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGAGTTCA
    ARPC2 Expression
    About this image


    ARPC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    ARPC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARPC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.529303
        Pathway & Disease-focused RT2 Profiler PCR Array including ARPC2: 
              Cytoskeleton Regulators in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARPC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARPC2 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arpc21 , 5 actin related protein 2/3 complex, subunit 21, 5 94.22(n)1
    99.33(a)1
      1 (38.49 cM)5
    767091  NM_029711.11  NP_083987.11 
     742364975 
    chicken
    (Gallus gallus)
    Aves ARPC21 actin related protein 2/3 complex, subunit 2, 34kDa 85.56(n)
    94.67(a)
      429041  XM_426598.4  XP_426598.2 
    lizard
    (Anolis carolinensis)
    Reptilia ARPC26
    actin related protein 2/3 complex, subunit 2, 34kD...
    73(a)
    1 ↔ 1
    1(88909849-88940355)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.81282 Xenopus laevis, Similar to actin related protein 2/3 more 79.59(n)    BC041545.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.268572 Danio rerio cDNA clone MGC77769 IMAGE7001086, complete more 79.59(n)    BC064304.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Arc-p343
    Arpc21
    regulation of actin polymerization
    and/or depolymerization more3
    Actin-related protein 2/3 complex, subunit 21
    75(a)3
    67.12(n)1
    75.76(a)1
      38C63
    353111  NM_136189.31  NP_610033.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y6D11A.23
    arx-41
    arx-41 70(a)3
    68.23(n)1
    70.9(a)1
      III(862298-865250)3
    1752471  NM_171077.51  NP_741088.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARC35(YNR035C)4 Subunit of the ARP2/3 complex, which is required for more   --   14(694047-693019) 855771  NP_014433.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons DIS21 DIS2 41.61(n)
    29.02(a)
      839965  NM_102820.2  NP_564364.1 


    ENSEMBL Gene Tree for ARPC2 (if available)
    TreeFam Gene Tree for ARPC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for ARPC2 (see all 831)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs796422251,2
    C--219079835(+) AAAGAA/GAGAAA 1 -- us2k10--------
    rs75870381,2
    C,F,H--219079878(+) gaaagA/Ggatta 1 -- us2k1 trp37Minor allele frequency- G:0.10NS EA NA CSA 420
    rs1390294321,2
    C--219079912(+) TTGTGA/GAAGAG 1 -- us2k10--------
    rs1861829601,2
    --219080023(+) TATTTC/TAGTTC 1 -- us2k10--------
    rs75872831,2
    C,F,H--219080150(+) ccagcC/Gtgccc 2 -- us2k115Minor allele frequency- G:0.01NS EA NA WA CSA 556
    rs116950321,2
    H--219080329(+) gagacA/Cccatc 2 -- us2k10--------
    rs64360441,2
    C--219080503(+) agggcG/Atggtg 2 -- us2k111Minor allele frequency- A:0.07NA WA CSA EA 372
    rs1918568301,2
    --219080610(+) GCACTC/TCAGCC 2 -- us2k10--------
    rs1840965051,2
    C--219080661(+) TTAAGC/TTAGCG 2 -- us2k10--------
    rs1167282141,2
    C,F--219080668(+) AGCGTA/GTAATT 2 -- us2k11Minor allele frequency- G:0.04WA 118

    HapMap Linkage Disequilibrium report for ARPC2 (219081817 - 219119079 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ARPC2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARPC2
    DNA2.0 Custom Variant and Variant Library Synthesis for ARPC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604224    OMIM disorders: --

    8 diseases for ARPC2:    
    About MalaCards
    diffuse scleroderma    shigellosis    scleroderma    wiskott-aldrich syndrome
    ulcerative colitis    inflammatory bowel disease    obesity    malaria


    ARPC2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARPC2
    Human Genome Epidemiology (HuGE) Navigator: ARPC2 (2 documents)

    Export disorders for ARPC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARPC2 gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with ARPC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PubMed id 9230079)1, 2, 3 Welch M.D.... Mitchison T.J. (J. Cell Biol. 1997)
    2. Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk. (PubMed id 19861958)1, 4 Festen E.A....Weersma R.K. (Am. J. Gastroenterol. 2010)
    3. Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. (PubMed id 18836448)1, 4 Franke A....Schreiber S. (Nat. Genet. 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    6. Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. (PubMed id 11741539)1, 2 Gournier H.... Welch M.D. (Mol. Cell 2001)
    7. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. (PubMed id 9359840)1, 3 Machesky L.M.... Segal A.W. (Biochem. J. 1997)
    8. Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13. (PubMed id 8812419)1, 2 Couch F.J.... Simard J. (Genomics 1996)
    9. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    10. Insertions within the actin core of actin-related protein 3 (Arp3) modulate branching nucleation by Arp2/3 complex. (PubMed id 23148219)1 Liu S.L....Nolen B.J. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10109 HGNC: 705 AceView: ARPC2 Ensembl:ENSG00000163466 euGenes: HUgn10109
    ECgene: ARPC2 Kegg: 10109 H-InvDB: ARPC2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ARPC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ARPC2 gene:
    Search GeneIP for patents involving ARPC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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