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Aliases for ARPC2 Gene

Aliases for ARPC2 Gene

  • Actin Related Protein 2/3 Complex Subunit 2 2 3 5
  • Arp2/3 Complex 34 KDa Subunit 3 4
  • P34-Arc 3 4
  • ARC34 3 4
  • Actin Related Protein 2/3 Complex, Subunit 2 (34 KD) 2
  • Actin Related Protein 2/3 Complex, Subunit 2, 34kDa 3
  • Actin Related Protein 2/3 Complex Subunit 2, 34kDa 2
  • Actin-Related Protein 2/3 Complex Subunit 2 3
  • Testis Tissue Sperm-Binding Protein Li 53e 3
  • ARP2/3 Protein Complex Subunit 34 3
  • PNAS-139 3
  • PRO2446 3

External Ids for ARPC2 Gene

Previous GeneCards Identifiers for ARPC2 Gene

  • GC02P217097
  • GC02P217803
  • GC02P219045
  • GC02P219284
  • GC02P218907
  • GC02P218790
  • GC02P219081
  • GC02P210935

Summaries for ARPC2 Gene

Entrez Gene Summary for ARPC2 Gene

  • This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARPC2 Gene

ARPC2 (Actin Related Protein 2/3 Complex Subunit 2) is a Protein Coding gene. Among its related pathways are Immune System and Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include actin filament binding and kinesin binding.

UniProtKB/Swiss-Prot for ARPC2 Gene

  • Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.

Gene Wiki entry for ARPC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARPC2 Gene

Genomics for ARPC2 Gene

Regulatory Elements for ARPC2 Gene

Enhancers for ARPC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F218180 0.9 ENCODE 15.3 -36.0 -36049 1.6 ELF3 ARID4B SIN3A ZSCAN9 DNMT3B ZNF48 CHAMP1 RARA SLC30A9 ZNF766 ENSG00000261338 ARPC2 GPBAR1 AAMP FAM134A CXCR1 HMGB1P9
GH02F218186 1 Ensembl ENCODE 12.2 -29.7 -29655 2.5 ELF3 CTCF MXI1 SAP130 MAX RAD21 RFXANK PATZ1 ZNF143 SMC3 ENSG00000261338 ARPC2 PNKD AAMP GPBAR1 HMGB1P9 CXCR1
GH02F218269 1.1 ENCODE 10.3 +55.5 55546 7.1 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ENSG00000261338 RNF25 LOC105373878 BCS1L AAMP ARPC2 STK36 PNKD TMBIM1 MIR6513
GH02F218168 1 Ensembl ENCODE 10.8 -47.6 -47569 1.9 CTCF ZNF654 RFX1 ZNF133 CEBPB TRIM22 EBF1 RAD21 RELA YY1 ARPC2 CXCR1 HMGB1P9
GH02F218366 1.3 FANTOM5 ENCODE 8.3 +152.8 152782 6.8 HDGF TBP HDAC1 ATF1 CBX3 TBL1XR1 CREB3L1 RAD21 ZBTB40 ETS1 SLC11A1 ENSG00000261338 ARPC2 CXCR2 CXCR1 CATIP PNKD CNOT9 TMBIM1 USP37
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARPC2 on UCSC Golden Path with GeneCards custom track

Promoters for ARPC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000607581 806 3401 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207

Genomic Location for ARPC2 Gene

Chromosome:
2
Start:
218,217,094 bp from pter
End:
218,254,356 bp from pter
Size:
37,263 bases
Orientation:
Plus strand

Genomic View for ARPC2 Gene

Genes around ARPC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARPC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARPC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPC2 Gene

Proteins for ARPC2 Gene

  • Protein details for ARPC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15144-ARPC2_HUMAN
    Recommended name:
    Actin-related protein 2/3 complex subunit 2
    Protein Accession:
    O15144
    Secondary Accessions:
    • Q92801
    • Q9P1D4

    Protein attributes for ARPC2 Gene

    Size:
    300 amino acids
    Molecular mass:
    34333 Da
    Quaternary structure:
    • Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.
    SequenceCaution:
    • Sequence=AAC50874.1; Type=Frameshift; Positions=14; Evidence={ECO:0000305}; Sequence=AAF71122.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ARPC2 Gene

Post-translational modifications for ARPC2 Gene

  • Ubiquitination at Lys 65, Lys 127, Lys 269, Lys 275, and Lys 295
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for ARPC2
  • Cloud-Clone Corp. Antibodies for ARPC2

No data available for DME Specific Peptides for ARPC2 Gene

Domains & Families for ARPC2 Gene

Gene Families for ARPC2 Gene

Protein Domains for ARPC2 Gene

Graphical View of Domain Structure for InterPro Entry

O15144

UniProtKB/Swiss-Prot:

ARPC2_HUMAN :
  • Belongs to the ARPC2 family.
Family:
  • Belongs to the ARPC2 family.
genes like me logo Genes that share domains with ARPC2: view

Function for ARPC2 Gene

Molecular function for ARPC2 Gene

GENATLAS Biochemistry:
actin related protein 2/3 complex,subunit 2 (34kDa),localized to the lamellipodia of stationary and locomoting fibroblasts,inducing actin polymerization and potentially participating in lamellipodial protrusion
UniProtKB/Swiss-Prot Function:
Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.

Gene Ontology (GO) - Molecular Function for ARPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton IDA 11741539
GO:0005515 protein binding IPI 11162547
GO:0051015 contributes_to actin filament binding IDA 11741539
genes like me logo Genes that share ontologies with ARPC2: view
genes like me logo Genes that share phenotypes with ARPC2: view

Animal Models for ARPC2 Gene

MGI Knock Outs for ARPC2:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ARPC2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARPC2 Gene

Localization for ARPC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARPC2 Gene

Cytoplasm, cytoskeleton. Cell projection. Cell junction, synapse, synaptosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARPC2 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
plasma membrane 2
nucleus 2
golgi apparatus 2
endosome 2

Gene Ontology (GO) - Cellular Components for ARPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA --
GO:0005768 endosome IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ARPC2: view

Pathways & Interactions for ARPC2 Gene

genes like me logo Genes that share pathways with ARPC2: view

Gene Ontology (GO) - Biological Process for ARPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 9230079
GO:0010592 positive regulation of lamellipodium assembly IMP 18560548
GO:0030833 regulation of actin filament polymerization IEA --
GO:0030838 positive regulation of actin filament polymerization IEA --
GO:0034314 Arp2/3 complex-mediated actin nucleation IEA,IDA 11741539
genes like me logo Genes that share ontologies with ARPC2: view

No data available for SIGNOR curated interactions for ARPC2 Gene

Drugs & Compounds for ARPC2 Gene

(3) Drugs for ARPC2 Gene - From: DrugBank and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one Experimental Pharma Target 0
N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide Experimental Pharma Target 0
CK-636 Pharma Arp2/3 complex inhibitor 0

(1) ApexBio Compounds for ARPC2 Gene

Compound Action Cas Number
CK-636 Arp2/3 complex inhibitor 442632-72-6
genes like me logo Genes that share compounds with ARPC2: view

Transcripts for ARPC2 Gene

Unigene Clusters for ARPC2 Gene

Actin related protein 2/3 complex, subunit 2, 34kDa:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ARPC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARPC2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13
SP1: - - - - - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - -
SP7: -
SP8: - -
SP9:
SP10: - - - - - - - -
SP11: - - - - -
SP12: - - - -

Relevant External Links for ARPC2 Gene

GeneLoc Exon Structure for
ARPC2
ECgene alternative splicing isoforms for
ARPC2

Expression for ARPC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARPC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARPC2 Gene

This gene is overexpressed in Whole Blood (x6.8).

Protein differential expression in normal tissues from HIPED for ARPC2 Gene

This gene is overexpressed in Lymph node (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARPC2 Gene



Protein tissue co-expression partners for ARPC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARPC2 Gene:

ARPC2

SOURCE GeneReport for Unigene cluster for ARPC2 Gene:

Hs.529303
genes like me logo Genes that share expression patterns with ARPC2: view

No data available for mRNA Expression by UniProt/SwissProt for ARPC2 Gene

Orthologs for ARPC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARPC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARPC2 34 35
  • 99.78 (n)
cow
(Bos Taurus)
Mammalia ARPC2 34 35
  • 96.11 (n)
dog
(Canis familiaris)
Mammalia ARPC2 34 35
  • 95.46 (n)
rat
(Rattus norvegicus)
Mammalia Arpc2 34
  • 94.33 (n)
mouse
(Mus musculus)
Mammalia Arpc2 34 16 35
  • 94.22 (n)
oppossum
(Monodelphis domestica)
Mammalia ARPC2 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARPC2 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARPC2 34 35
  • 85.56 (n)
lizard
(Anolis carolinensis)
Reptilia ARPC2 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arpc2 34
  • 78.64 (n)
Str.2022 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8128 34
zebrafish
(Danio rerio)
Actinopterygii arpc2 34 35
  • 76.85 (n)
Dr.26857 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9084 34
fruit fly
(Drosophila melanogaster)
Insecta Arc-p34 36 35
  • 75 (a)
Arpc2 34
  • 67.12 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta ARPC2_ANOGA 34
  • 65.77 (n)
worm
(Caenorhabditis elegans)
Secernentea Y6D11A.2 36
  • 70 (a)
arx-4 34 35
  • 68.23 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARC35 35 37
  • 32 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons DIS2 34
  • 41.61 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10350 35
  • 70 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU03050 34
  • 56.77 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arc2 34
  • 55.21 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5746 34
Species where no ortholog for ARPC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARPC2 Gene

ENSEMBL:
Gene Tree for ARPC2 (if available)
TreeFam:
Gene Tree for ARPC2 (if available)

Paralogs for ARPC2 Gene

No data available for Paralogs for ARPC2 Gene

Variants for ARPC2 Gene

Sequence variations from dbSNP and Humsavar for ARPC2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10169718 -- 218,238,857(+) TGAGT(A/G)TAGAA intron-variant
rs10171347 -- 218,251,075(+) aggca(A/G)tccac intron-variant
rs10171570 -- 218,251,324(+) ctctt(A/G)cctca intron-variant
rs10171820 -- 218,242,564(+) tttgg(C/T)agaca intron-variant
rs10178462 -- 218,218,630(+) CTGGT(G/T)AACTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ARPC2 Gene

Variant ID Type Subtype PubMed ID
esv3594330 CNV gain 21293372
nsv1013137 CNV gain 25217958

Variation tolerance for ARPC2 Gene

Residual Variation Intolerance Score: 26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARPC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARPC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARPC2 Gene

Disorders for ARPC2 Gene

Relevant External Links for ARPC2

Genetic Association Database (GAD)
ARPC2
Human Genome Epidemiology (HuGE) Navigator
ARPC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARPC2

No disorders were found for ARPC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARPC2 Gene

Publications for ARPC2 Gene

  1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PMID: 9230079) Welch M.D. … Mitchison T.J. (J. Cell Biol. 1997) 2 3 4 64
  2. Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk. (PMID: 19861958) Festen E.A. … Weersma R.K. (Am. J. Gastroenterol. 2010) 3 46 64
  3. Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. (PMID: 18836448) Franke A. … Schreiber S. (Nat. Genet. 2008) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4 64

Products for ARPC2 Gene

Sources for ARPC2 Gene

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