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Aliases for ARPC1B Gene

Aliases for ARPC1B Gene

  • Actin Related Protein 2/3 Complex Subunit 1B 2 3 5
  • ARP2/3 Protein Complex Subunit P41 2 3
  • Arp2/3 Complex 41 KDa Subunit 3 4
  • P41-ARC 3 4
  • ARC41 3 4
  • Actin Related Protein 2/3 Complex, Subunit 1A (41 KD) 2
  • Actin Related Protein 2/3 Complex, Subunit 1B (41 KD) 2
  • Actin Related Protein 2/3 Complex, Subunit 1B, 41kDa 3
  • Actin Related Protein 2/3 Complex Subunit 1B, 41kDa 2
  • Actin-Related Protein 2/3 Complex Subunit 1B 3
  • P40-ARC 3

External Ids for ARPC1B Gene

Previous GeneCards Identifiers for ARPC1B Gene

  • GC07P097507
  • GC07P098569
  • GC07P098583
  • GC07P098616
  • GC07P098705
  • GC07P098810
  • GC07P098937
  • GC07P093608
  • GC07P098971

Summaries for ARPC1B Gene

Entrez Gene Summary for ARPC1B Gene

  • This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011]

GeneCards Summary for ARPC1B Gene

ARPC1B (Actin Related Protein 2/3 Complex Subunit 1B) is a Protein Coding gene. Among its related pathways are Immune response CCR3 signaling in eosinophils and Innate Immune System. GO annotations related to this gene include actin binding and structural constituent of cytoskeleton. An important paralog of this gene is ENSG00000284292.

UniProtKB/Swiss-Prot for ARPC1B Gene

  • Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

Gene Wiki entry for ARPC1B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARPC1B Gene

Genomics for ARPC1B Gene

Regulatory Elements for ARPC1B Gene

Enhancers for ARPC1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G099371 1.8 FANTOM5 Ensembl ENCODE dbSUPER 17.1 -1.5 -1499 1.6 ATF1 MLX ZFP64 ARID4B DMAP1 ZNF48 SP5 MXD4 NFYC MIER2 ARPC1B ATP5J2 PILRB CPSF4 PTCD1 PIR48819
GH07G099373 1.8 FANTOM5 ENCODE dbSUPER 15.8 +4.1 4060 9.0 HDGF PKNOX1 CREB3L1 AGO1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 TRRAP TMEM225B ARPC1B ZNF394 BUD31 GPC2 LOC100131859 ZNF789 PILRA ATP5J2
GH07G099324 1.2 ENCODE 20.4 -45.6 -45611 7.3 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 NFYC MEF2D ARPC1B BUD31 PDAP1 TRRAP MBLAC1 ENSG00000242798 TMEM225B CPSF4 CYP3A5 ATP5J2
GH07G099140 1.7 FANTOM5 ENCODE dbSUPER 11.3 -231.4 -231387 4.7 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 DMAP1 ZNF766 ZNF548 KLF13 ZSCAN25 LOC100131859 RPS3AP26 ZNF655 LOC101927550 SMURF1 LOC100419643 TRRAP ARPC1B COPS6
GH07G099207 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.6 -164.2 -164232 5.9 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 ZNF121 FOS SMURF1 ARPC1B TRIM4 PDAP1 BUD31 ARPC1A FAM200A ZNF655 PTCD1 KPNA7
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARPC1B on UCSC Golden Path with GeneCards custom track

Promoters for ARPC1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000215660 751 2001 HDGF CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF143 FOS

Genomic Location for ARPC1B Gene

Chromosome:
7
Start:
99,374,249 bp from pter
End:
99,394,801 bp from pter
Size:
20,553 bases
Orientation:
Plus strand

Genomic View for ARPC1B Gene

Genes around ARPC1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARPC1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARPC1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPC1B Gene

Proteins for ARPC1B Gene

  • Protein details for ARPC1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15143-ARC1B_HUMAN
    Recommended name:
    Actin-related protein 2/3 complex subunit 1B
    Protein Accession:
    O15143
    Secondary Accessions:
    • Q9BU00

    Protein attributes for ARPC1B Gene

    Size:
    372 amino acids
    Molecular mass:
    40950 Da
    Quaternary structure:
    • Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

neXtProt entry for ARPC1B Gene

Post-translational modifications for ARPC1B Gene

  • Ubiquitination at posLast=4949, posLast=8282, Lys87, Lys110, and posLast=341341
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ARPC1B Gene

Domains & Families for ARPC1B Gene

Suggested Antigen Peptide Sequences for ARPC1B Gene

Graphical View of Domain Structure for InterPro Entry

O15143

UniProtKB/Swiss-Prot:

ARC1B_HUMAN :
  • Belongs to the WD repeat ARPC1 family.
Family:
  • Belongs to the WD repeat ARPC1 family.
genes like me logo Genes that share domains with ARPC1B: view

Function for ARPC1B Gene

Molecular function for ARPC1B Gene

UniProtKB/Swiss-Prot Function:
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

Gene Ontology (GO) - Molecular Function for ARPC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton TAS,IDA 11741539
GO:0032403 protein complex binding IEA --
GO:0051015 contributes_to actin filament binding IDA 11741539
genes like me logo Genes that share ontologies with ARPC1B: view
genes like me logo Genes that share phenotypes with ARPC1B: view

Animal Models for ARPC1B Gene

MGI Knock Outs for ARPC1B:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARPC1B Gene

Localization for ARPC1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARPC1B Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARPC1B gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 4

Gene Ontology (GO) - Cellular Components for ARPC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005885 Arp2/3 protein complex IEA,IDA 11741539
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with ARPC1B: view

Pathways & Interactions for ARPC1B Gene

genes like me logo Genes that share pathways with ARPC1B: view

SIGNOR curated interactions for ARPC1B Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ARPC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 9230079
GO:0030833 regulation of actin filament polymerization IEA --
GO:0032355 response to estradiol IEA --
GO:0034314 Arp2/3 complex-mediated actin nucleation IEA,IDA 11741539
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
genes like me logo Genes that share ontologies with ARPC1B: view

Drugs & Compounds for ARPC1B Gene

(2) Drugs for ARPC1B Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one Experimental Pharma Target 0
N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide Experimental Pharma Target 0
genes like me logo Genes that share compounds with ARPC1B: view

Transcripts for ARPC1B Gene

Unigene Clusters for ARPC1B Gene

Actin related protein 2/3 complex, subunit 1B, 41kDa:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARPC1B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ·
SP1: - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - -
SP8: - - - - - - - - -
SP9: - - - - -
SP10: - - - - - -
SP11: - - - - - - -
SP12: - -
SP13:
SP14:
SP15: - - - -
SP16: - - - - - -
SP17: - -
SP18: - - - - - - - - -
SP19: - - - - - - - - - -
SP20:
SP21:

ExUns: 12d · 12e ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b · 15c · 15d ^ 16a · 16b · 16c
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21: -

Relevant External Links for ARPC1B Gene

GeneLoc Exon Structure for
ARPC1B
ECgene alternative splicing isoforms for
ARPC1B

Expression for ARPC1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARPC1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARPC1B Gene

This gene is overexpressed in Whole Blood (x13.7).

Protein differential expression in normal tissues from HIPED for ARPC1B Gene

This gene is overexpressed in NK cells (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARPC1B Gene



Protein tissue co-expression partners for ARPC1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARPC1B Gene:

ARPC1B

SOURCE GeneReport for Unigene cluster for ARPC1B Gene:

Hs.489284

Evidence on tissue expression from TISSUES for ARPC1B Gene

  • Blood(4)
  • Liver(4)
  • Lung(4)
  • Skin(4)
genes like me logo Genes that share expression patterns with ARPC1B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARPC1B Gene

Orthologs for ARPC1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARPC1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARPC1B 34 35
  • 99.19 (n)
cow
(Bos Taurus)
Mammalia ARPC1B 34 35
  • 90.57 (n)
dog
(Canis familiaris)
Mammalia ARPC1B 34 35
  • 90.05 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ARPC1B 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arpc1b 34
  • 88.89 (n)
mouse
(Mus musculus)
Mammalia Arpc1b 34 16 35
  • 88.8 (n)
oppossum
(Monodelphis domestica)
Mammalia ARPC1B 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARPC1B 34 35
  • 85.09 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia arpc1b 34
  • 72.99 (n)
African clawed frog
(Xenopus laevis)
Amphibia arx-3and3n122-prov 34
zebrafish
(Danio rerio)
Actinopterygii arpc1b 34 35
  • 74.73 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sop2 36 35
  • 50 (a)
worm
(Caenorhabditis elegans)
Secernentea arx-3 35
  • 50 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARC40 35
  • 36 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ARPC1B 34
  • 50.46 (n)
rice
(Oryza sativa)
Liliopsida Os02g0817200 34
  • 48.42 (n)
Os.18424 34
barley
(Hordeum vulgare)
Liliopsida Hv.12702 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10119 35
  • 51 (a)
OneToMany
Species where no ortholog for ARPC1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARPC1B Gene

ENSEMBL:
Gene Tree for ARPC1B (if available)
TreeFam:
Gene Tree for ARPC1B (if available)

Paralogs for ARPC1B Gene

Paralogs for ARPC1B Gene

genes like me logo Genes that share paralogs with ARPC1B: view

Variants for ARPC1B Gene

Sequence variations from dbSNP and Humsavar for ARPC1B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000067653 -- 99,393,494(+) GGTGG(A/G)GGCGG intron-variant
rs1000078522 -- 99,393,737(+) CTGCC(C/G)CCACC intron-variant
rs1000195668 -- 99,382,117(+) GGGCT(A/G)GTGGG intron-variant
rs1000240346 -- 99,387,886(+) CAGAG(C/T)GAGAC intron-variant
rs1000649885 -- 99,387,519(+) GATCA(C/T)CTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARPC1B Gene

Variant ID Type Subtype PubMed ID
nsv1124247 CNV deletion 24896259
nsv831068 CNV loss 17160897
nsv831069 CNV loss 17160897
nsv951379 CNV deletion 24416366

Variation tolerance for ARPC1B Gene

Residual Variation Intolerance Score: 70.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.78; 58.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARPC1B Gene

Human Gene Mutation Database (HGMD)
ARPC1B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARPC1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARPC1B Gene

Disorders for ARPC1B Gene

Relevant External Links for ARPC1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARPC1B

No disorders were found for ARPC1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARPC1B Gene

Publications for ARPC1B Gene

  1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PMID: 9230079) Welch M.D. … Mitchison T.J. (J. Cell Biol. 1997) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate. (PMID: 14749719) Vadlamudi R.K. … Kumar R. (EMBO Rep. 2004) 3 22 64
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4 64
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64

Products for ARPC1B Gene

Sources for ARPC1B Gene

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