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Aliases for ARPC1B Gene

Aliases for ARPC1B Gene

  • Actin Related Protein 2/3 Complex, Subunit 1B, 41kDa 2 3
  • ARC41 3 4 6
  • ARP2/3 Protein Complex Subunit P41 2 3
  • Arp2/3 Complex 41 KDa Subunit 3 4
  • P41-ARC 3 4
  • Actin Related Protein 2/3 Complex, Subunit 1B (41 KD) 2
  • Actin-Related Protein 2/3 Complex Subunit 1B 3
  • Actin Related Protein 2/3 Complex 2
  • Subunit 1A (41 KD) 2
  • P40-ARC 3

External Ids for ARPC1B Gene

Summaries for ARPC1B Gene

Entrez Gene Summary for ARPC1B Gene

  • This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011]

GeneCards Summary for ARPC1B Gene

ARPC1B (Actin Related Protein 2/3 Complex, Subunit 1B, 41kDa) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and Immune response CCR3 signaling in eosinophils. GO annotations related to this gene include actin binding and structural constituent of cytoskeleton. An important paralog of this gene is ARPC1A.

UniProtKB/Swiss-Prot for ARPC1B Gene

  • Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks

Gene Wiki entry for ARPC1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARPC1B Gene

Genomics for ARPC1B Gene

Genomic Location for ARPC1B Gene

Start:
99,374,249 bp from pter
End:
99,394,801 bp from pter
Size:
20,553 bases
Orientation:
Plus strand

Genomic View for ARPC1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARPC1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPC1B Gene

Regulatory Elements for ARPC1B Gene

Proteins for ARPC1B Gene

  • Protein details for ARPC1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15143-ARC1B_HUMAN
    Recommended name:
    Actin-related protein 2/3 complex subunit 1B
    Protein Accession:
    O15143
    Secondary Accessions:
    • Q9BU00

    Protein attributes for ARPC1B Gene

    Size:
    372 amino acids
    Molecular mass:
    40950 Da
    Quaternary structure:
    • Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC

neXtProt entry for ARPC1B Gene

Proteomics data for ARPC1B Gene at MOPED

Post-translational modifications for ARPC1B Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys18, Lys49, Lys82, Lys87, Lys110, Lys165, and Lys341

No data available for DME Specific Peptides for ARPC1B Gene

Domains for ARPC1B Gene

Gene Families for ARPC1B Gene

HGNC:
  • ARPC :Actin related protein 2/3 complex subunits
  • WDR :WD repeat domain containing

UniProtKB/Swiss-Prot:

ARC1B_HUMAN
Family:
  • Belongs to the WD repeat ARPC1 family.:
    • O15143
Similarity:
  • Contains 6 WD repeats.:
    • O15143
genes like me logo Genes that share domains with ARPC1B: view

Function for ARPC1B Gene

Molecular function for ARPC1B Gene

UniProtKB/Swiss-Prot Function: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks

Gene Ontology (GO) - Molecular Function for ARPC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding --
GO:0005200 structural constituent of cytoskeleton IDA 11741539
GO:0005515 protein binding --
GO:0051015 contributes_to actin filament binding IDA 11741539
genes like me logo Genes that share ontologies with ARPC1B: view

Phenotypes for ARPC1B Gene

MGI mutant phenotypes for ARPC1B:
inferred from 1 alleles
GenomeRNAi human phenotypes for ARPC1B:
genes like me logo Genes that share phenotypes with ARPC1B: view

miRNA for ARPC1B Gene

miRTarBase miRNAs that target ARPC1B

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARPC1B Gene

Localization for ARPC1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARPC1B Gene

Cytoplasm, cytoskeleton.

Gene Ontology (GO) - Cellular Components for ARPC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton --
GO:0005885 Arp2/3 protein complex IDA 11741539
GO:0005925 focal adhesion IDA 21423176
GO:0015629 actin cytoskeleton TAS 9230079
genes like me logo Genes that share ontologies with ARPC1B: view

Pathways for ARPC1B Gene

genes like me logo Genes that share pathways with ARPC1B: view

Gene Ontology (GO) - Biological Process for ARPC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 9230079
GO:0030833 regulation of actin filament polymerization --
GO:0034314 Arp2/3 complex-mediated actin nucleation IDA 11741539
genes like me logo Genes that share ontologies with ARPC1B: view

Compounds for ARPC1B Gene

(2) Drugbank Compounds for ARPC1B Gene

genes like me logo Genes that share compounds with ARPC1B: view

Transcripts for ARPC1B Gene

Unigene Clusters for ARPC1B Gene

Actin related protein 2/3 complex, subunit 1B, 41kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARPC1B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ·
SP1: - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - -
SP8: - - - - - - - - -
SP9: - - - - -
SP10: - - - - - -
SP11: - - - - - - -
SP12: - -
SP13:
SP14:
SP15: - - - -
SP16: - - - - - -
SP17: - -
SP18: - - - - - - - - -
SP19: - - - - - - - - - -
SP20:
SP21:

ExUns: 12d · 12e ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b · 15c · 15d ^ 16a · 16b · 16c
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21: -

Relevant External Links for ARPC1B Gene

GeneLoc Exon Structure for
ARPC1B
ECgene alternative splicing isoforms for
ARPC1B

Expression for ARPC1B Gene

mRNA expression in normal human tissues for ARPC1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARPC1B Gene

This gene is overexpressed in Whole Blood (13.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARPC1B Gene

SOURCE GeneReport for Unigene cluster for ARPC1B Gene Hs.489284

genes like me logo Genes that share expressions with ARPC1B: view

Orthologs for ARPC1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARPC1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARPC1B 36
  • 99.19 (n)
  • 99.73 (a)
ARPC1B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARPC1B 36
  • 90.57 (n)
  • 95.96 (a)
ARPC1B 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARPC1B 36
  • 90.05 (n)
  • 96.24 (a)
ARPC1B 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arpc1b 36
  • 88.8 (n)
  • 97.31 (a)
Arpc1b 16
Arpc1b 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARPC1B 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARPC1B 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arpc1b 36
  • 88.89 (n)
  • 96.77 (a)
chicken
(Gallus gallus)
Aves ARPC1B 36
  • 85.09 (n)
  • 88.62 (a)
ARPC1B 37
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia arx-3and3n122-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia arpc1b 36
  • 72.99 (n)
  • 84.28 (a)
zebrafish
(Danio rerio)
Actinopterygii arpc1b 36
  • 74.73 (n)
  • 81.25 (a)
arpc1b 37
  • 81 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sop2 37
  • 49 (a)
OneToMany
Sop2 38
  • 50 (a)
worm
(Caenorhabditis elegans)
Secernentea arx-3 37
  • 50 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARC40 37
  • 36 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ARPC1B 36
  • 50.46 (n)
  • 44.17 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.12702 36
rice
(Oryza sativa)
Liliopsida Os.18424 36
Os02g0817200 36
  • 48.42 (n)
  • 42.46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10119 37
  • 51 (a)
OneToMany
Species with no ortholog for ARPC1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARPC1B Gene

ENSEMBL:
Gene Tree for ARPC1B (if available)
TreeFam:
Gene Tree for ARPC1B (if available)

Paralogs for ARPC1B Gene

Paralogs for ARPC1B Gene

genes like me logo Genes that share paralogs with ARPC1B: view

Variants for ARPC1B Gene

Sequence variations from dbSNP and Humsavar for ARPC1B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs4765 -- 99,386,776(+) CACAA(C/T)GGGCA reference, synonymous-codon
rs757779 -- 99,393,244(-) ACCTG(A/G)GCTGC intron-variant
rs1045012 - 99,386,731(-) CCGCT(C/G)TTTTC missense, reference
rs1127839 -- 99,374,776(+) GGGCG(C/G)GGGAG utr-variant-5-prime
rs2057905 -- 99,387,512(-) GATCC(A/G)CCCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARPC1B Gene

Variant ID Type Subtype PubMed ID
nsv831068 CNV Loss 17160897
nsv831069 CNV Loss 17160897

Relevant External Links for ARPC1B Gene

HapMap Linkage Disequilibrium report
ARPC1B

Disorders for ARPC1B Gene

No disorders were found for ARPC1B Gene.

No data available for UniProtKB/Swiss-Prot for ARPC1B Gene

Publications for ARPC1B Gene

  1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PMID: 9230079) Welch M.D. … Mitchison T.J. (J. Cell Biol. 1997) 2 3 4
  2. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. (PMID: 9359840) Machesky L.M. … Segal A.W. (Biochem. J. 1997) 2 3
  3. p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate. (PMID: 14749719) Vadlamudi R.K. … Kumar R. (EMBO Rep. 2004) 3 23
  4. Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. (PMID: 11741539) Gournier H. … Welch M.D. (Mol. Cell 2001) 3 4
  5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4

Products for ARPC1B Gene

Sources for ARPC1B Gene

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