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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ARPC1B Gene

protein-coding GIFtS: 64
GCID: GC07P098971

actin related protein 2/3 complex, subunit 1B, 41kDa

(Previous names: actin related protein 2/3 complex, subunit 1B (41 kD) )

Explore 8 diseases affiliated with
ARPC1B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Actin Related Protein 2/3 Complex, Subunit 1B, 41kDa¹ ²		Arp2/3 Complex 41 KDa Subunit² ³
ARC41¹ ² ³ ⁵		Actin Related Protein 2/3 Complex, Subunit 1B (41 KD)¹
P41-ARC¹		Actin-Related Protein 2/3 Complex Subunit 1B²
P40-ARC¹		ARP2/3 Protein Complex Subunit P41²

External Ids:	HGNC: 704¹	Entrez Gene: 10095²	Ensembl: ENSG00000130429⁷	OMIM: 604223⁵	UniProtKB: O15143³

Export aliases for ARPC1B gene to outside databases

Previous GC identifers: GC07P097507 GC07P098569 GC07P098583 GC07P098616 GC07P098705 GC07P098810 GC07P098937 GC07P093608

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARPC1B:

This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2

family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two

proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in

the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and

maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the

complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by

being an activator and substrate of the Aurora A kinase. (provided by RefSeq, Mar 2011)

UniProtKB/Swiss-Prot: ARC1B_HUMAN, O15143

Function: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and

together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks

Gene Wiki entry for ARPC1B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ARPC1B gene promoter:
Nkx3-1 STAT1 Nkx3-1 v4 STAT1beta Nkx3-1 v1 STAT1alpha MZF-1 Nkx3-1 v2 Nkx3-1 v3 MRF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): ARPC1B promoter sequence

Search SABiosciences Chromatin IP Primers for ARPC1B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARPC1B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q

ARPC1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARPC1B gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P098971: view genomic region (about GC identifiers)

Start:	98,971,872 bp from pter	End:	98,992,424 bp from pter
Size:	20,553 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 98,332,102-98,352,197

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ARC1B_HUMAN, O15143 (See protein sequence)

Recommended Name: Actin-related protein 2/3 complex subunit 1B

Size: 372 amino acids; 40950 Da

Subunit: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC,

ARPC4/p20-ARC and ARPC5/p16-ARC

Subcellular location: Cytoplasm, cytoskeleton

Secondary accessions: Q9BU00

Explore the universe of human proteins at neXtProt for ARPC1B: NX_O15143

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O15143

ARPC1B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005711.1

ENSEMBL proteins:

ENSP00000413173 ENSP00000398620 ENSP00000252725 ENSP00000410238 ENSP00000413067

ENSP00000408758 ENSP00000403324 ENSP00000398110 ENSP00000403211 ENSP00000388802

ENSP00000389631 ENSP00000412164 ENSP00000408508 ENSP00000399955

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	Uscn Proteins for ARPC1B

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005856	cytoskeleton	--	--
GO:0005885	Arp2/3 protein complex	TAS	9230079
GO:0015629	actin cytoskeleton	TAS	9230079

ARPC1B for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ARPC1B for domains About GeneDecksing

4 InterPro domains/families:

IPR017383 ARPC2/3_su1

IPR001680 WD40_repeat

IPR017986 WD40_repeat_dom

IPR015943 WD40/YVTN_repeat-like_dom

Graphical View of Domain Structure for InterPro Entry O15143

ProtoNet protein and cluster: O15143

1 Blocks protein family: IPB001680 G-protein beta WD-40 repeat signature

UniProtKB/Swiss-Prot: ARC1B_HUMAN, O15143

Similarity: Belongs to the WD repeat ARPC1 family

Similarity: Contains 6 WD repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ARC1B_HUMAN, O15143

Function: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and

together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks

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		SwitchGear 3'UTR luciferase reporter plasmid: ARPC1B 3' UTR sequence

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARPC1B

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--
GO:0005200	structural constituent of cytoskeleton	TAS	9230079

ARPC1B for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ARPC1B:

Decreased focal adhesion (FA)

Animal Models:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Arpc1b):

homeostasis/metabolism

ARPC1B for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell adhesion_Integrin-mediated cell adhesion and migration

Cell adhesion_Integrin-mediated cell adhesion and migration	1.00	Cytoskeleton remodeling_Integrin outside-in signaling	0.37
Cell adhesion Integrin-mediated cell adhesion and migration	1.00	Cytoskeleton remodeling Integrin outside-in signaling	0.37
Cytoskeleton remodeling_Regulation of actin cytoskeleton by Rho GTPases	0.49	Cytoskeleton remodeling Fibronectin-binding integrins in cell motility	0.32
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases	0.49	Cytoskeleton remodeling_Fibronectin-binding integrins in cell motility	0.32

G-protein signaling_RAC1 in cellular process

G-protein signaling_RAC1 in cellular process	1.00	Cytoskeleton remodeling CDC42 in cellular processes	0.37
G-protein signaling RAC1 in cellular process	1.00	RAC1 signaling pathway	0.34
Cytoskeleton remodeling_CDC42 in cellular processes	0.37	CDC42 signaling events	0.17

Cytoskeleton remodeling Slit-Robo signaling

	Cytoskeleton remodeling Slit-Robo signaling	1.00			Cell adhesion_Cadherin-mediated cell adhesion	0.28
	Development_Slit-Robo signaling	0.92			Cell adhesion Cadherin-mediated cell adhesion	0.28

Immune response CD16 signaling in NK cells

	Immune response CD16 signaling in NK cells	1.00			Immune response_Role of DAP12 receptors in NK cells	0.32
	Immune response_CD16 signaling in NK cells	0.99			Immune response Role of DAP12 receptors in NK cells	0.32

Immune response _CCR3 signaling in eosinophils

	Immune response _CCR3 signaling in eosinophils	1.00			Inhibitory action of Lipoxins on neutrophil migration	0.51
	Immune response CCR3 signaling in eosinophils	1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/13 EMD Millipore Pathways for ARPC1B (see all 13)

	Cytoskeleton remodeling Integrin outside-in signaling
	Immune response CD16 signaling in NK cells
	Cytoskeleton remodeling CDC42 in cellular processes
	Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
	Immune response Role of DAP12 receptors in NK cells

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ARPC1B

	THC Differentiation Pathway
	Salmonella Infection

5/14 GeneGo (Thomson Reuters) Pathways for ARPC1B (see all 14)

	Cytoskeleton remodeling CDC42 in cellular processes
	Immune response CD16 signaling in NK cells
	Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
	Neurophysiological process Receptor-mediated axon growth repulsion
	Cytoskeleton remodeling Integrin outside-in signaling

5 BioSystems Pathways for ARPC1B

	Pathogenic Escherichia coli infection
	B Cell Receptor Signaling Pathway
	RAC1 signaling pathway
	ErbB1 downstream signaling
	CDC42 signaling events

5 Kegg Pathways (Kegg details for ARPC1B):

	Fc gamma R-mediated phagocytosis
	Regulation of actin cytoskeleton
	Bacterial invasion of epithelial cells
	Pathogenic Escherichia coli infection
	Shigellosis

ARPC1B for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ARPC1B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/38 Interacting proteins for ARPC1B (O15143^{2, 3} ENSP00000252725⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 38)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
WAS	P42768²^,³, ENSP00000365891⁴	MINT-14050 I2D: score=2 STRING: ENSP00000365891
WASL	O00401²^,³, ENSP00000223023⁴	MINT-15597 I2D: score=1 STRING: ENSP00000223023
ACTR2	P61160³, ENSP00000367220⁴	I2D: score=2 STRING: ENSP00000367220
ACTR3B	Q9P1U1³, ENSP00000256001⁴	I2D: score=2 STRING: ENSP00000256001
PAK1	Q13153³, ENSP00000278568⁴	I2D: score=2 STRING: ENSP00000278568

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006928	cellular component movement	TAS	9230079
GO:0030833	regulation of actin filament polymerization	IEA	--

ARPC1B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ARPC1B

2 DrugBank Compounds for ARPC1B About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
(2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one	--	--	target	--	10592235
N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide	--	--	target	--	10592235

Search CenterWatch for drugs/clinical trials and news about ARPC1B / ARC1B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ARPC1B gene:

NM_005720.3

Unigene Cluster for ARPC1B:

Actin related protein 2/3 complex, subunit 1B, 41kDa

Hs.489284 [show with all ESTs]

Unigene Representative Sequence: BM907771

18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):

ENST00000443222 ENST00000414376 ENST00000252725(uc003upz.3) ENST00000484600

ENST00000455009 ENST00000484375 ENST00000418347 ENST00000429246 ENST00000417330

ENST00000431816 ENST00000427217 ENST00000458033 ENST00000451682 ENST00000451694

ENST00000474880 ENST00000445924 ENST00000432343 ENST00000493403

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		hsa-miR-1206 hsa-miR-634 hsa-miR-545 hsa-miR-124 hsa-miR-3658 hsa-miR-127-5p hsa-miR-330-3p hsa-miR-506

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Additional cDNA sequence:

AF006084.1 AK314818.1 AY007111.1 BC002562.2 BC002988.1 BC007555.1

24/34 DOTS entries (see all 34):

DT.100885268 DT.448721 DT.100885265 DT.97857993 DT.100885252 DT.100885251 DT.100885257 DT.91724215

DT.121072413 DT.97860817 DT.100885240 DT.91768110 DT.100885249 DT.92032340 DT.100885239 DT.100039258

DT.95229983 DT.121072278 DT.121072158 DT.100843492 DT.121072351 DT.434580 DT.95229923 DT.100760456

24/1160 AceView cDNA sequences (see all 1160):

BG685816 AI672103 BM782586 AA313239 BM767716 BQ669457 CR607425 BG489270

AF006084 AI955698 BQ008759 BG750483 BQ924626 BX438949 AI650428 BC002562

BU501205 CD743069 AA356777 AA306535 BM836004 BQ668491 BG577041 BQ670574

GeneLoc Exon Structure

5/21 Alternative Splicing Database (ASD) splice patterns (SP) for ARPC1B (see all 21) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	^	7	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	·	11c	^	12a	·	12b	·	12c	·
SP1:													-		-		-		-				-		-												-		-
SP2:													-		-		-		-				-		-												-		-								-		-		-
SP3:																			-				-		-												-		-
SP4:													-		-								-		-												-		-
SP5:													-		-				-				-		-												-		-

ExUns:	12d	·	12e	^	13	^	14a	·	14b	·	14c	^	15a	·	15b	·	15c	·	15d	^	16a	·	16b	·	16c
SP1:																			-		-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for ARPC1B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ARPC1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACTGCTTCA

About this image

ARPC1B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Reproductive System

Mesonephros

Mesonephric cells

Reproductive System

Kidney

Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ARPC1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARPC1B

SOURCE GeneReport for Unigene cluster: Hs.489284

SABiosciences Expression via Pathway-Focused PCR Array including ARPC1B:

Cytoskeleton Regulators in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARPC1B gene from 8/29 species (see all 29) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Arpc1b^{1 , 5}	actin related protein 2/3 complex, subunit 1B^{1, 5}	88.8(n)¹ 97.31(a)¹		5 (85.03 cM)⁵ 11867¹ NM_023142.2¹ NP_075631.2¹ 145114215⁵
chicken (Gallus gallus)	Aves	ARPC1B¹	actin related protein 2/3 complex, subunit 1B, 41kDa	85.09(n) 88.62(a)		416490 NM_001030632.1 NP_001025803.1
African clawed frog (Xenopus laevis)	Amphibia	arx-3and3n122-prov²	actin related protein 2/3 complex, subunit 1B (41 kDa)	75.92(n)		BC045043.1
zebrafish (Danio rerio)	Actinopterygii	BC053229.1²	--	78.86(n)		BC053229.1
fruit fly (Drosophila melanogaster)	Insecta	Sop2³	actin filament-based process actin binding	50(a)		34D6 --
worm (Caenorhabditis elegans)	Secernentea	arx-3⁶	ARp2/3 compleX component family member (arx-3)	50(a)	possible ortholog	III(12052328-12058358)
thale cress (Arabidopsis thaliana)	eudicotyledons	ARPC1B¹	actin-related protein C1B	50.46(n) 44.17(a)		817687 NM_128686.2 NP_180688.1
rice (Oryza sativa)	Liliopsida	Os.18424²	Oryza sativa (japonica cultivar-group) cDNA clone0 more	70.3(n)		AK073919.1

ENSEMBL Gene Tree for ARPC1B (if available)
TreeFam Gene Tree for ARPC1B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ARPC1B gene

ARPC1A²

2 SIMAP similar genes for ARPC1B using alignment to 15 protein entries: ARC1B_HUMAN (see all proteins):

ARPC1A SEH1L

ARPC1B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113904874^1,2	C,	--	98330176(+)	`GAGGTG/TACCAG`	1	--	us2k¹		2		WA	120
rs73395595^1,2	C,	--	98330193(+)	`GGTTAC/TTTCTC`	1	--	us2k¹		2		WA	120
rs41279845^1,2		--	98351712(+)	`TCCAAC/TCCAGC`	1	--	ds500¹		0	--	--	--	--
rs4729534^1,2	C,F,A,H	--	98351833(+)	`CCGTTC/TTGCCT`	1	--	ds500¹		8		NS EA NA	626
rs11764955^1,2	H	--	98351927(+)	`GGGAAA/GCGGGG`	1	--	ds500¹		0	--	--	--	--
rs1062889^1,2	C	--	98351974(+)	`TGTTTC/TTGGGG`	1	--	ds500¹ ese³		2		NA	4
rs704798^1,2	C,F,A,H,	--	98352026(+)	`GAGGGA/G/TACAGA`	1	--	ds500¹ trp³		9		MN NA WA CSA	432
rs1044936^1,2	C,A,H	--	98352044(+)	`CTTTTC/TTTACC`	1	--	ds500¹		5		NS EA NA	422
rs1044979^1,2	C,H	--	98352074(+)	`TTTTTC/TTTAAA`	1	--	ut3¹ trp³		4		NS EA	420
rs200789467^1,2	C	--	98352094(+)	`TTATTA/GAAAAA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ARPC1B (98971872 - 98992424 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ARPC1B
2 CNVs: 4547 4548

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARPC1B

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ARPC1B for disorders           About GeneDecksing

OMIM gene information: 604223    OMIM disorders: --

8 diseases for ARPC1B:    About MalaCards

chronic lymphocytic leukemia lymphocytic leukemia shigellosis choroiditis

gastric cancer leukemia melanoma malaria

Export disorders for ARPC1B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ARPC1B gene, integrated from 9 sources (see all 39):
(articles sorted by number of sources associating them with ARPC1B)

Utopia: connect your pdf to the dynamic
world of online information

The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PubMed id 9230079)^{1, 2, 3} Welch M.D.... Mitchison T.J. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{1, 2} Gevaert K.... Vandekerckhove J. (2003)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)
Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. (PubMed id 11741539)^{1, 2} Gournier H.... Welch M.D. (2001)
Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. (PubMed id 9359840)^{1, 3} Machesky L.M.... Segal A.W. (1997)
p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate. (PubMed id 14749719)^{1, 9} Vadlamudi R.K....Kumar R. (2004)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10095	HGNC: 704	AceView: ARPC1B	Ensembl:ENSG00000130429	euGenes: HUgn10095
ECgene: ARPC1B	Kegg: 10095	H-InvDB: ARPC1B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ARPC1B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ARPC1B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ARPC1B gene:
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GeneCards and IP:
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ARPC1B Gene

actin related protein 2/3 complex, subunit 1B, 41kDa

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ARPC1B Gene

actin related protein 2/3 complex, subunit 1B, 41kDa

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