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ARPC1B Gene

protein-coding   GIFtS: 63
GCID: GC07P098971

Actin Related Protein 2/3 Complex, Subunit 1B, 41kDa

(Previous names: actin related protein 2/3 complex, subunit 1B (41 kD))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Actin Related Protein 2/3 Complex, Subunit 1B, 41kDa1 2     Actin Related Protein 2/3 Complex1
ARC412 3 5     Actin Related Protein 2/3 Complex, Subunit 1B (41 KD)1
ARP2/3 Protein Complex Subunit P411 2     Subunit 1A (41 KD)1
Arp2/3 Complex 41 KDa Subunit2 3     Actin-Related Protein 2/3 Complex Subunit 1B2
p41-ARC2 3     p40-ARC2

External Ids:    HGNC: 7041   Entrez Gene: 100952   Ensembl: ENSG000001304297   OMIM: 6042235   UniProtKB: O151433   

Export aliases for ARPC1B gene to outside databases

Previous GC identifers: GC07P097507 GC07P098569 GC07P098583 GC07P098616 GC07P098705 GC07P098810 GC07P098937 GC07P093608


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARPC1B Gene:
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2
family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two
proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated
in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling
and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions
of the complex to different cell types or developmental stages. This protein also has a role in centrosomal
homeostasis by being an activator and substrate of the Aurora A kinase. (provided by RefSeq, Mar 2011)

GeneCards Summary for ARPC1B Gene:
ARPC1B (actin related protein 2/3 complex, subunit 1B, 41kDa) is a protein-coding gene. GO annotations related to this gene include actin binding and structural constituent of cytoskeleton. An important paralog of this gene is ARPC1A.

UniProtKB/Swiss-Prot: ARC1B_HUMAN, O15143
Function: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and
together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks

Gene Wiki entry for ARPC1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARPC1B gene promoter:
         Nkx3-1   STAT1   Nkx3-1 v4   STAT1beta   Nkx3-1 v1   STAT1alpha   MZF-1   Nkx3-1 v2   Nkx3-1 v3   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): ARPC1B promoter sequence
   Search Chromatin IP Primers for ARPC1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARPC1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

ARPC1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARPC1B gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P098971:  view genomic region     (about GC identifiers)

Start:
98,971,872 bp from pter      End:
98,992,424 bp from pter
Size:
20,553 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 98,332,071-98,352,197     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARC1B_HUMAN, O15143 (See protein sequence)
Recommended Name: Actin-related protein 2/3 complex subunit 1B  
Size: 372 amino acids; 40950 Da
Subunit: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC,
ARPC4/p20-ARC and ARPC5/p16-ARC
Secondary accessions: Q9BU00

Explore the universe of human proteins at neXtProt for ARPC1B: NX_O15143

Explore proteomics data for ARPC1B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys18, Lys49, Lys82, Lys87, Lys110, Lys165, Lys341
  • Modification sites at PhosphoSitePlus

  • See ARPC1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005711.1  
    ENSEMBL proteins: 
     ENSP00000413173   ENSP00000398620   ENSP00000252725   ENSP00000410238   ENSP00000413067  
     ENSP00000408758   ENSP00000403324   ENSP00000398110   ENSP00000403211   ENSP00000388802  
     ENSP00000389631   ENSP00000408508   ENSP00000399955  

    ARPC1B Human Recombinant Protein Products:

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    Novus Biologicals ARPC1B Protein
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    Cloud-Clone Corp. Proteins for ARPC1B

     
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    Cloud-Clone Corp. ELISAs for ARPC1B
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    Search eBioscience for ELISAs for ARPC1B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARPC: Actin related protein 2/3 complex subunits
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR017383 ARPC2/3_su1
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry O15143

    ProtoNet protein and cluster: O15143

    1 Blocks protein domain: IPB001680 G-protein beta WD-40 repeat signature

    UniProtKB/Swiss-Prot: ARC1B_HUMAN, O15143
    Similarity: Belongs to the WD repeat ARPC1 family
    Similarity: Contains 6 WD repeats


    Find genes that share domains with ARPC1B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARC1B_HUMAN, O15143
    Function: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and
    together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005200structural constituent of cytoskeleton TAS9230079
    GO:0005515protein binding ----
         
    Find genes that share ontologies with ARPC1B           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ARPC1B:
     Decreased focal adhesion (FA)  

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Arpc1b):
     homeostasis/metabolism 

    Find genes that share phenotypes with ARPC1B           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARPC1B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARPC1B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARPC1B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARPC1B

    miRNA
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    miRTarBase miRNAs that target ARPC1B:
    hsa-mir-124-3p (MIRT002566)

    Block miRNA regulation of human, mouse, rat ARPC1B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARPC1B (see all 9):
    hsa-miR-1206 hsa-miR-634 hsa-miR-545 hsa-miR-124 hsa-miR-3658 hsa-miR-127-5p hsa-miR-330-3p hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidARPC1B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ARPC1B
    Predesigned siRNA for gene silencing in human, mouse, rat ARPC1B

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: ARPC1B (NM_005720)
    Sino Biological Human cDNA Clone for ARPC1B
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARPC1B

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARPC1B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARC1B_HUMAN, O15143: Cytoplasm, cytoskeleton

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton ----
    GO:0005885Arp2/3 protein complex TAS9230079
    GO:0015629actin cytoskeleton TAS9230079
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with ARPC1B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARPC1B About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    Cytoskeleton remodeling Slit Robo signaling0.92
    Neurophysiological process Receptor mediated axon growth repulsion0.41
    Pathogenic Escherichia coli infection0.43
    2Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils0.51
    3Cell adhesion Integrin mediated cell adhesion and migration
    Cell adhesion Integrin mediated cell adhesion and migration0.49
    Cytoskeleton remodeling Integrin outside in signaling0.37
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    Cytoskeleton remodeling Fibronectin binding integrins in cell motility0.32
    4G protein signaling RAC1 in cellular process
    G protein signaling RAC1 in cellular process0.37
    Cytoskeleton remodeling CDC42 in cellular processes0.37
    5CDC42 signaling events
    CDC42 signaling events0.34
    RAC1 signaling pathway0.34


    Find genes that share SuperPaths with ARPC1B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ARPC1B
        THC Differentiation Pathway
    Salmonella Infection

    Selected GeneGo (Thomson Reuters) Pathways for ARPC1B (see all 14)
        Cytoskeleton remodeling CDC42 in cellular processes
    Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling Integrin outside-in signaling

    5 BioSystems Pathways for ARPC1B
        B Cell Receptor Signaling Pathway
    Pathogenic Escherichia coli infection
    CDC42 signaling events
    ErbB1 downstream signaling
    RAC1 signaling pathway



    Selected Kegg Pathways  (Kegg details for ARPC1B) (see all 6):
        Fc gamma R-mediated phagocytosis
    Regulation of actin cytoskeleton
    Bacterial invasion of epithelial cells
    Pathogenic Escherichia coli infection
    Shigellosis

        Pathway & Disease-focused RT2 Profiler PCR Array including ARPC1B: 
              Cytoskeleton Regulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ARPC1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARPC1B (O151432, 3 ENSP000002527254) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WASP427682, 3, ENSP000003658914MINT-14050 I2D: score=2 STRING: ENSP00000365891
    WASLO004012, 3, ENSP000002230234MINT-15597 I2D: score=1 STRING: ENSP00000223023
    ACTR2P611603, ENSP000003672204I2D: score=2 STRING: ENSP00000367220
    ACTR3BQ9P1U13, ENSP000002560014I2D: score=2 STRING: ENSP00000256001
    PAK1Q131533, ENSP000002785684I2D: score=2 STRING: ENSP00000278568
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement TAS9230079
    GO:0030833regulation of actin filament polymerization IEA--

    Find genes that share ontologies with ARPC1B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARPC1B (ARC1B)

    2 DrugBank Compounds for ARPC1B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one-- --target--10592235
    N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARPC1B gene: 
    NM_005720.3  

    Unigene Cluster for ARPC1B:

    Actin related protein 2/3 complex, subunit 1B, 41kDa
    Hs.489284  [show with all ESTs]
    Unigene Representative Sequence: BM907771
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000443222 ENST00000414376 ENST00000252725(uc003upz.3) ENST00000455009
    ENST00000484375 ENST00000418347 ENST00000429246 ENST00000417330 ENST00000431816
    ENST00000427217 ENST00000458033 ENST00000484600 ENST00000451682 ENST00000474880
    ENST00000445924 ENST00000432343 ENST00000493403 ENST00000468337
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ARPC1B (see all 9):
    hsa-miR-1206 hsa-miR-634 hsa-miR-545 hsa-miR-124 hsa-miR-3658 hsa-miR-127-5p hsa-miR-330-3p hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidARPC1B 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: ARPC1B (NM_005720)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARPC1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARPC1B
    Primer
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    OriGene qPCR primer pairs and template standards for ARPC1B
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARPC1B
      QuantiTect SYBR Green Assays in human, mouse, rat ARPC1B
      QuantiFast Probe-based Assays in human, mouse, rat ARPC1B

    Additional mRNA sequence: 

    AF006084.1 AK314818.1 AY007111.1 BC002562.2 BC002988.1 BC007555.1 

    Selected DOTS entries (see all 34):

    DT.100885268  DT.448721  DT.100885265  DT.97857993  DT.100885252  DT.100885251  DT.100885257  DT.91724215 
    DT.121072413  DT.97860817  DT.100885240  DT.91768110  DT.100885249  DT.92032340  DT.100885239  DT.100039258 
    DT.95229983  DT.121072278  DT.121072158  DT.100843492  DT.121072351  DT.434580  DT.95229923  DT.100760456 

    Selected AceView cDNA sequences (see all 1160):

    CR617089 CF127489 BQ057985 CR601410 AA548554 BI862147 BM008663 BQ918733 
    CB216645 BU155636 CR606640 BI859735 BI838320 BM475580 BM970592 AU133699 
    BM767624 AW170155 BM742030 BM825676 BE276648 BU173102 AA633465 BE561020 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARPC1B (see all 21)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ·
    SP1:                                      -     -     -     -           -     -                                   -     -                                       
    SP2:                                      -     -     -     -           -     -                                   -     -                       -     -     -   
    SP3:                                                        -           -     -                                   -     -                                       
    SP4:                                      -     -                       -     -                                   -     -                                       
    SP5:                                      -     -           -           -     -                                   -     -                                       

    ExUns: 12d · 12e ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b · 15c · 15d ^ 16a · 16b · 16c
    SP1:                                                        -     -               
    SP2:                                                                              
    SP3:                                                                              
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for ARPC1B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARPC1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTGCTTCA
    ARPC1B Expression
    About this image


    ARPC1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Primitive Heart Tube Cells Primitive Heart Tube
             Heart Tube
     
     Intermediate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Mesonephric cells Mesonephros
             Mesonephros
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Kidney (Urinary System)
             Metanephros
     
     Gonad
             Mesonephric cells Mesonephros
    ARPC1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARPC1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.489284
        Pathway & Disease-focused RT2 Profiler PCR Array including ARPC1B: 
              Cytoskeleton Regulators in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARPC1B gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arpc1b1 , 5 actin related protein 2/3 complex, subunit 1B1, 5 88.8(n)1
    97.31(a)1
      5 (85.03 cM)5
    118671  NM_023142.21  NP_075631.21 
     1451142155 
    chicken
    (Gallus gallus)
    Aves ARPC1B1 actin related protein 2/3 complex, subunit 1B, 41kDa 85.09(n)
    88.62(a)
      416490  NM_001030632.1  NP_001025803.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia arx-3and3n122-prov2 actin related protein 2/3 complex, subunit 1B (41 kDa) 75.92(n)    BC045043.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC053229.12   -- 78.86(n)    BC053229.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sop23 actin filament-based process actin
    binding
    50(a)   34D6   --
    worm
    (Caenorhabditis elegans)
    Secernentea arx-36
    Protein ARX-3 (arx-3) mRNA, complete cds
    50(a)
    1 → many
    III(12052428-12058458) WBGene00000201
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARC406
    Subunit of the ARP2/3 complex, which is required f...
    36(a)
    1 → many
    II(685438-686592) YBR234C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ARPC1B1 ARPC1B 50.46(n)
    44.17(a)
      817687  NM_128686.2  NP_180688.1 
    rice
    (Oryza sativa)
    Liliopsida Os.184242 Oryza sativa (japonica cultivar-group) cDNA clone0 more 70.3(n)    AK073919.1 


    ENSEMBL Gene Tree for ARPC1B (if available)
    TreeFam Gene Tree for ARPC1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARPC1B gene
    ARPC1A2  
    2 SIMAP similar genes for ARPC1B using alignment to 14 protein entries:     ARC1B_HUMAN (see all proteins):
    ARPC1A    SEH1L

    Find genes that share paralogs with ARPC1B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARPC1B (see all 465)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs102553991,2
    C,F,A,H--98330073(+) AAGAGG/CGAGAC 1 -- us2k1 trp310Minor allele frequency- C:0.50NA WA CSA EA 369
    rs102709171,2
    C,F,A,H--98330163(+) GACCTG/TCCAGT 1 -- us2k123Minor allele frequency- T:0.48NS EA NA WA CSA 2349
    rs1139048741,2
    C,F--98330176(+) GAGGTG/TACCAG 1 -- us2k12Minor allele frequency- T:0.04WA 120
    rs733955951,2
    C,F--98330193(+) GGTTAC/TTTCTC 1 -- us2k12Minor allele frequency- T:0.04WA 120
    rs1401502341,2
    C--98970429(+) AGCAGA/GACAGG 1 -- us2k10--------
    rs1463697651,2
    --98970627(+) TAAAA-/CCCACC 1 -- us2k10--------
    rs2017692421,2
    C--98970627(+) CTAAAA/CCCACC 1 -- us2k10--------
    rs102587571,2
    C,F,A,H--98970675(+) AAATAT/CGCAGG 1 -- us2k127Minor allele frequency- C:0.49NS EA NA WA CSA 2711
    rs1503599971,2
    C--98970712(+) AAGTTC/TGAGCA 1 -- us2k10--------
    rs342117741,2
    C--98970723(+) CTTCC-/TGTGTG 1 -- us2k12Minor allele frequency- T:0.25NA 4

    HapMap Linkage Disequilibrium report for ARPC1B (98971872 - 98992424 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ARPC1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831068CNV Loss17160897
    nsv831069CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ARPC1B
    DNA2.0 Custom Variant and Variant Library Synthesis for ARPC1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604223    OMIM disorders: --


    Find genes that share disorders with ARPC1B           About GenesLikeMe


    Export disorders for ARPC1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARPC1B gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with ARPC1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PubMed id 9230079)1, 2, 3 Welch M.D.... Mitchison T.J. (J. Cell Biol. 1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    5. Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. (PubMed id 11741539)1, 2 Gournier H.... Welch M.D. (Mol. Cell 2001)
    6. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. (PubMed id 9359840)1, 3 Machesky L.M.... Segal A.W. (Biochem. J. 1997)
    7. p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate. (PubMed id 14749719)1, 9 Vadlamudi R.K....Kumar R. (EMBO Rep. 2004)
    8. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    9. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10095 HGNC: 704 AceView: ARPC1B Ensembl:ENSG00000130429 euGenes: HUgn10095
    ECgene: ARPC1B Kegg: 10095 H-InvDB: ARPC1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARPC1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARPC1B gene:
    Search GeneIP for patents involving ARPC1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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