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Aliases for ARPC1B Gene

Aliases for ARPC1B Gene

  • Actin Related Protein 2/3 Complex Subunit 1B 2 3 5
  • Actin Related Protein 2/3 Complex Subunit 1B, 41kDa 2 3
  • ARP2/3 Protein Complex Subunit P41 2 3
  • Arp2/3 Complex 41 KDa Subunit 3 4
  • P41-ARC 3 4
  • ARC41 3 4
  • Actin Related Protein 2/3 Complex, Subunit 1B (41 KD) 2
  • Actin Related Protein 2/3 Complex, Subunit 1B, 41kDa 3
  • Actin Related Protein 2/3 Complex 2
  • Subunit 1A (41 KD) 2
  • P40-ARC 3

External Ids for ARPC1B Gene

Previous GeneCards Identifiers for ARPC1B Gene

  • GC07P097507
  • GC07P098569
  • GC07P098583
  • GC07P098616
  • GC07P098705
  • GC07P098810
  • GC07P098937
  • GC07P093608
  • GC07P098971

Summaries for ARPC1B Gene

Entrez Gene Summary for ARPC1B Gene

  • This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011]

GeneCards Summary for ARPC1B Gene

ARPC1B (Actin Related Protein 2/3 Complex Subunit 1B) is a Protein Coding gene. Among its related pathways are Bacterial invasion of epithelial cells and Regulation of actin dynamics for phagocytic cup formation. GO annotations related to this gene include actin binding and structural constituent of cytoskeleton. An important paralog of this gene is ARPC1A.

UniProtKB/Swiss-Prot for ARPC1B Gene

  • Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

Gene Wiki entry for ARPC1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARPC1B Gene

Genomics for ARPC1B Gene

Regulatory Elements for ARPC1B Gene

Enhancers for ARPC1B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARPC1B on UCSC Golden Path with GeneCards custom track

Promoters for ARPC1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARPC1B on UCSC Golden Path with GeneCards custom track

Genomic Location for ARPC1B Gene

Chromosome:
7
Start:
99,374,249 bp from pter
End:
99,394,801 bp from pter
Size:
20,553 bases
Orientation:
Plus strand

Genomic View for ARPC1B Gene

Genes around ARPC1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARPC1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARPC1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPC1B Gene

Proteins for ARPC1B Gene

  • Protein details for ARPC1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15143-ARC1B_HUMAN
    Recommended name:
    Actin-related protein 2/3 complex subunit 1B
    Protein Accession:
    O15143
    Secondary Accessions:
    • Q9BU00

    Protein attributes for ARPC1B Gene

    Size:
    372 amino acids
    Molecular mass:
    40950 Da
    Quaternary structure:
    • Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

neXtProt entry for ARPC1B Gene

Proteomics data for ARPC1B Gene at MOPED

Post-translational modifications for ARPC1B Gene

  • Ubiquitination at Lys 49, Lys 82, Lys 87, Lys 110, and Lys 341
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARPC1B Gene

Domains & Families for ARPC1B Gene

Suggested Antigen Peptide Sequences for ARPC1B Gene

Graphical View of Domain Structure for InterPro Entry

O15143

UniProtKB/Swiss-Prot:

ARC1B_HUMAN :
  • Belongs to the WD repeat ARPC1 family.
  • Contains 6 WD repeats.
Family:
  • Belongs to the WD repeat ARPC1 family.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with ARPC1B: view

Function for ARPC1B Gene

Molecular function for ARPC1B Gene

UniProtKB/Swiss-Prot Function:
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

Gene Ontology (GO) - Molecular Function for ARPC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051015 contributes_to actin filament binding IDA 11741539
genes like me logo Genes that share ontologies with ARPC1B: view
genes like me logo Genes that share phenotypes with ARPC1B: view

Animal Models for ARPC1B Gene

MGI Knock Outs for ARPC1B:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARPC1B Gene

Localization for ARPC1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARPC1B Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARPC1B Gene COMPARTMENTS Subcellular localization image for ARPC1B gene
Compartment Confidence
cytoskeleton 5
extracellular 5
cytosol 4

Gene Ontology (GO) - Cellular Components for ARPC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005885 Arp2/3 protein complex IEA,IDA 11741539
genes like me logo Genes that share ontologies with ARPC1B: view

Pathways & Interactions for ARPC1B Gene

genes like me logo Genes that share pathways with ARPC1B: view

SIGNOR curated interactions for ARPC1B Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ARPC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 9230079
GO:0007411 axon guidance TAS --
GO:0030833 regulation of actin filament polymerization IEA --
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with ARPC1B: view

Drugs & Compounds for ARPC1B Gene

(2) Drugs for ARPC1B Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one Experimental Pharma Target 0
N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide Experimental Pharma Target 0
genes like me logo Genes that share compounds with ARPC1B: view

Transcripts for ARPC1B Gene

Unigene Clusters for ARPC1B Gene

Actin related protein 2/3 complex, subunit 1B, 41kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARPC1B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ·
SP1: - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - -
SP8: - - - - - - - - -
SP9: - - - - -
SP10: - - - - - -
SP11: - - - - - - -
SP12: - -
SP13:
SP14:
SP15: - - - -
SP16: - - - - - -
SP17: - -
SP18: - - - - - - - - -
SP19: - - - - - - - - - -
SP20:
SP21:

ExUns: 12d · 12e ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b · 15c · 15d ^ 16a · 16b · 16c
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21: -

Relevant External Links for ARPC1B Gene

GeneLoc Exon Structure for
ARPC1B
ECgene alternative splicing isoforms for
ARPC1B

Expression for ARPC1B Gene

mRNA expression in normal human tissues for ARPC1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARPC1B Gene

This gene is overexpressed in Whole Blood (x13.7).

Protein differential expression in normal tissues from HIPED for ARPC1B Gene

This gene is overexpressed in NK cells (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARPC1B Gene



SOURCE GeneReport for Unigene cluster for ARPC1B Gene Hs.489284

genes like me logo Genes that share expression patterns with ARPC1B: view

Protein tissue co-expression partners for ARPC1B Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ARPC1B Gene

Orthologs for ARPC1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARPC1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARPC1B 35
  • 90.57 (n)
  • 95.96 (a)
ARPC1B 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARPC1B 35
  • 90.05 (n)
  • 96.24 (a)
ARPC1B 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arpc1b 35
  • 88.8 (n)
  • 97.31 (a)
Arpc1b 16
Arpc1b 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARPC1B 35
  • 99.19 (n)
  • 99.73 (a)
ARPC1B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arpc1b 35
  • 88.89 (n)
  • 96.77 (a)
oppossum
(Monodelphis domestica)
Mammalia ARPC1B 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARPC1B 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARPC1B 35
  • 85.09 (n)
  • 88.62 (a)
ARPC1B 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arpc1b 35
  • 72.99 (n)
  • 84.28 (a)
African clawed frog
(Xenopus laevis)
Amphibia arx-3and3n122-prov 35
zebrafish
(Danio rerio)
Actinopterygii arpc1b 35
  • 74.73 (n)
  • 81.25 (a)
arpc1b 36
  • 81 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sop2 37
  • 50 (a)
Sop2 36
  • 49 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea arx-3 36
  • 50 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARC40 36
  • 36 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ARPC1B 35
  • 50.46 (n)
  • 44.17 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.12702 35
rice
(Oryza sativa)
Liliopsida Os.18424 35
Os02g0817200 35
  • 48.42 (n)
  • 42.46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10119 36
  • 51 (a)
OneToMany
Species with no ortholog for ARPC1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARPC1B Gene

ENSEMBL:
Gene Tree for ARPC1B (if available)
TreeFam:
Gene Tree for ARPC1B (if available)

Paralogs for ARPC1B Gene

Paralogs for ARPC1B Gene

genes like me logo Genes that share paralogs with ARPC1B: view

Variants for ARPC1B Gene

Sequence variations from dbSNP and Humsavar for ARPC1B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1045012 - 99,386,731(-) CCGCT(C/G)TTTTC reference, missense
rs1127839 -- 99,374,776(+) GGGCG(C/G)GGGAG utr-variant-5-prime
rs6955490 -- 99,376,965(+) ATGCC(A/G)GTAAA intron-variant, upstream-variant-2KB
rs13226604 -- 99,373,697(+) ctgca(A/G)cctct upstream-variant-2KB
rs13230430 -- 99,374,463(+) GCCCA(G/T)CGGCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ARPC1B Gene

Variant ID Type Subtype PubMed ID
nsv831068 CNV Loss 17160897
nsv831069 CNV Loss 17160897

Variation tolerance for ARPC1B Gene

Residual Variation Intolerance Score: 70.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.78; 58.07% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ARPC1B Gene

Disorders for ARPC1B Gene

Relevant External Links for ARPC1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARPC1B

No disorders were found for ARPC1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARPC1B Gene

Publications for ARPC1B Gene

  1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PMID: 9230079) Welch M.D. … Mitchison T.J. (J. Cell Biol. 1997) 2 3 4 67
  2. p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate. (PMID: 14749719) Vadlamudi R.K. … Kumar R. (EMBO Rep. 2004) 3 23
  3. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. (PMID: 9359840) Machesky L.M. … Segal A.W. (Biochem. J. 1997) 2 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for ARPC1B Gene

Sources for ARPC1B Gene

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