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ARPC1A Gene

protein-coding   GIFtS: 61
GCID: GC07P098923

Actin Related Protein 2/3 Complex, Subunit 1A, 41kDa

(Previous names: actin related protein 2/3 complex, subunit 1A (41 kD))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Actin Related Protein 2/3 Complex, Subunit 1A, 41kDa1 2     Arc402
SOP2-Like Protein1 2 3     HEL-682
SOP2L2 3 5     SOP2Hs2
Actin Binding Protein (Schizosaccharomyces Pombe Sop2-Like)1 2     Actin-Related Protein 2/3 Complex Subunit 1A2
Actin Related Protein 2/3 Complex, Subunit 1A (41 KD)1     Epididymis Luminal Protein 682

External Ids:    HGNC: 7031   Entrez Gene: 105522   Ensembl: ENSG000002416857   OMIM: 6042205   UniProtKB: Q927473   

Export aliases for ARPC1A gene to outside databases

Previous GC identifers: GC07P097458 GC07P098521 GC07P098534 GC07P098568 GC07P098761 GC07P093559


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARPC1A Gene:
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2
family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two
proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated
in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling
and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions
of the complex to different cell types or developmental stages. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2010)

GeneCards Summary for ARPC1A Gene:
ARPC1A (actin related protein 2/3 complex, subunit 1A, 41kDa) is a protein-coding gene. Diseases associated with ARPC1A include boomerang dysplasia, and lattice corneal dystrophy. GO annotations related to this gene include actin binding. An important paralog of this gene is ARPC1B.

UniProtKB/Swiss-Prot: ARC1A_HUMAN, Q92747
Function: Probably functions as component of the Arp2/3 complex which is involved in regulation of actin
polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of
branched actin networks

Gene Wiki entry for ARPC1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARPC1A gene promoter:
         AhR   SREBP-1c   Arnt   SREBP-1b   AREB6   POU2F1   SREBP-1a   POU2F1a   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ARPC1A promoter sequence
   Search Chromatin IP Primers for ARPC1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARPC1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

ARPC1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARPC1A gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P098923:  view genomic region     (about GC identifiers)

Start:
98,923,496 bp from pter      End:
98,985,787 bp from pter
Size:
62,292 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 98,283,446-98,323,834     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARC1A_HUMAN, Q92747 (See protein sequence)
Recommended Name: Actin-related protein 2/3 complex subunit 1A  
Size: 370 amino acids; 41569 Da
Subunit: Probable component of the Arp2/3 complex in which it may replace ARPC1B
Secondary accessions: A4D276 D6W5S1 Q7Z5U8 Q86WU5 Q8IXQ0

Explore the universe of human proteins at neXtProt for ARPC1A: NX_Q92747

Explore proteomics data for ARPC1A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys63, Lys87, Lys165, Lys290
  • Modification sites at PhosphoSitePlus

  • See ARPC1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001177925.1  NP_006400.2  

    ENSEMBL proteins: 
     ENSP00000412879   ENSP00000262942   ENSP00000408711   ENSP00000408578  
    Reactome Protein details: Q92747

    ARPC1A Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARPC: Actin related protein 2/3 complex subunits
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR017383 ARPC2/3_su1
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q92747

    ProtoNet protein and cluster: Q92747

    1 Blocks protein domain: IPB001680 G-protein beta WD-40 repeat signature

    UniProtKB/Swiss-Prot: ARC1A_HUMAN, Q92747
    Similarity: Belongs to the WD repeat ARPC1 family
    Similarity: Contains 6 WD repeats


    ARPC1A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARC1A_HUMAN, Q92747
    Function: Probably functions as component of the Arp2/3 complex which is involved in regulation of actin
    polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of
    branched actin networks

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding ----
         
    ARPC1A for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARPC1A:
     Decreased Tat-dependent transc  Increased peripheral focal adh 

    Animal Models:
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    miRTarBase miRNAs that target ARPC1A:
    hsa-mir-1274a (MIRT035843), hsa-mir-423-5p (MIRT038032), hsa-let-7i-5p (MIRT046551)

    Block miRNA regulation of human, mouse, rat ARPC1A using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARC1A_HUMAN, Q92747: Cytoplasm, cytoskeleton (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus2
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton ----
    GO:0015629actin cytoskeleton TAS8978670
    GO:0070062extracellular vesicular exosome IDA19056867

    ARPC1A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARPC1A About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    Cytoskeleton remodeling Slit Robo signaling0.92
    Neurophysiological process Receptor mediated axon growth repulsion0.41
    Pathogenic Escherichia coli infection0.43
    2Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils0.51
    3Cell adhesion Integrin mediated cell adhesion and migration
    Cell adhesion Integrin mediated cell adhesion and migration0.49
    Cytoskeleton remodeling Integrin outside in signaling0.37
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    Cytoskeleton remodeling Fibronectin binding integrins in cell motility0.32
    4Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.77
    Fcgamma receptor (FCGR) dependent phagocytosis0.77
    5G protein signaling RAC1 in cellular process
    G protein signaling RAC1 in cellular process0.37
    Cytoskeleton remodeling CDC42 in cellular processes0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected GeneGo (Thomson Reuters) Pathways for ARPC1A (see all 14)
        Cytoskeleton remodeling CDC42 in cellular processes
    Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling Integrin outside-in signaling

    1 BioSystems Pathway for ARPC1A
        Pathogenic Escherichia coli infection


    1 Reactome Pathway for ARPC1A
        Regulation of actin dynamics for phagocytic cup formation


    Selected Kegg Pathways  (Kegg details for ARPC1A) (see all 6):
        Fc gamma R-mediated phagocytosis
    Regulation of actin cytoskeleton
    Bacterial invasion of epithelial cells
    Pathogenic Escherichia coli infection
    Shigellosis


    ARPC1A for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARPC1A
    Interactions:

        Search GeneGlobe Interaction Network for ARPC1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARPC1A (Q927473 ENSP000002629424) via UniProtKB, MINT, STRING, and/or I2D (see all 110)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTR3BQ9P1U13, ENSP000002560014I2D: score=7 STRING: ENSP00000256001
    AARSD1Q9BTE63I2D: score=3 
    MYO1EQ129653, ENSP000002882354I2D: score=3 STRING: ENSP00000288235
    PAFAH1B1P430343, ENSP000003803784I2D: score=3 STRING: ENSP00000380378
    PTGES3L-AARSD1Q9BTE63I2D: score=3 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030036actin cytoskeleton organization TAS8978670
    GO:0030833regulation of actin filament polymerization IEA--
    GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS--
    GO:0045087innate immune response TAS--

    ARPC1A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARPC1A (ARC1A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARPC1A gene (2 alternative transcripts): 
    NM_001190996.1  NM_006409.3  

    Unigene Cluster for ARPC1A:

    Actin related protein 2/3 complex, subunit 1A, 41kDa
    Hs.124126  [show with all ESTs]
    Unigene Representative Sequence: NM_001190996
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000441989 ENST00000262942(uc003upx.2 uc003upy.2) ENST00000432786
    ENST00000471960 ENST00000463009 ENST00000477240 ENST00000432884(uc011kit.2)

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      QuantiFast Probe-based Assays in human, mouse, rat ARPC1A

    Additional mRNA sequence: 

    AB209059.1 AK223015.1 BC006445.1 BC039594.1 BC047889.1 BC054027.1 Y08999.1 

    Selected DOTS entries (see all 25):

    DT.118915  DT.100854337  DT.100854311  DT.100854339  DT.100854340  DT.99940694  DT.92454422  DT.95278412 
    DT.121054645  DT.121054663  DT.100854326  DT.101970044  DT.121054582  DT.121461824  DT.100768114  DT.100854333 
    DT.121054644  DT.121054662  DT.121462228  DT.92018573  DT.92064363  DT.92454421  DT.95278418  DT.95300095 

    Selected AceView cDNA sequences (see all 653):

    CR614310 AA761659 AI597606 CB215253 BU784505 BM851386 BE349395 BQ422409 
    CR606734 BM996460 AI918184 CA437688 BG681307 AI695893 BI905789 BU682205 
    BU627116 BQ684654 AI140822 BQ002099 AA365006 CR623383 BM459660 AU116954 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARPC1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAAACTGTG
    ARPC1A Expression
    About this image

    ARPC1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARPC1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.124126
        Custom PCR Arrays for ARPC1A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARPC1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARPC1A gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arpc1a1 , 5 actin related protein 2/3 complex, subunit 1A1, 5 90.81(n)1
    98.65(a)1
      5 (85.00 cM)5
    564431  NM_019767.21  NP_062741.11 
     1450838305 
    chicken
    (Gallus gallus)
    Aves ARPC1A1 actin related protein 2/3 complex, subunit 1A, 41kDa 83.69(n)
    95.95(a)
      770269  NM_001079495.2  NP_001072963.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARPC1A6
    actin related protein 2/3 complex, subunit 1A, 41k...
    95(a)
    1 ↔ 1
    GL343725.1(187661-199313)
    African clawed frog
    (Xenopus laevis)
    Amphibia arpc1a-prov2 actin related protein 2/3 complex, subunit 1A, 41kDa 78.97(n)    BC041267.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arpc1a2 actin related protein 2/3 complex, subunit 1A 79.22(n)   394243  AY398313.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sop23
    Arpc11
    actin filament-based process actin
    binding3
    Actin-related protein 2/3 complex, subunit 11
    58(a)3
    59.54(n)1
    58.97(a)1
      34D63
    347931  NM_057248.41  NP_476596.11 
    worm
    (Caenorhabditis elegans)
    Secernentea arx-31 arx-3 58.1(n)
    57.82(a)
      3565442  NM_067169.4  NP_499570.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARC40(YBR234C)4
    ARC401
    Subunit of the ARP2/3 complex, which is required for more4
    ARC401
    45.73(n)1
    40.63(a)1
      2(686592-685438)4
    8525361, 4  NP_009793.11, 4 
    corn
    (Zea mays)
    Liliopsida AY105528.12   -- 71.66(n)    AY105528.1 


    ENSEMBL Gene Tree for ARPC1A (if available)
    TreeFam Gene Tree for ARPC1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARPC1A gene
    ARPC1B2  
    1 SIMAP similar gene for ARPC1A using alignment to 5 protein entries:     ARC1A_HUMAN (see all proteins):
    ARPC1B

    ARPC1A for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for ARPC1A
    PGOHUM00000234760 PGOHUM00000240511 PGOHUM00000238151 PGOHUM00000245618 PGOHUM00000235652


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARPC1A (see all 844)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs69534761,2
    C,F,A,H--98921600(+) tggcaG/Ccagtg 2 -- us2k110Minor allele frequency- C:0.49NA WA CSA EA 370
    rs1474470831,2
    --98921696(+) TTAGAG/TTCTCA 2 -- us2k10--------
    rs570255111,2
    C,F--98921779(+) GCCCCC/TACTGA 2 -- us2k12Minor allele frequency- T:0.11WA 120
    rs1400247521,2
    --98921948(+) CTGCAC/GTAACT 2 -- us2k10--------
    rs102744071,2
    C,A,H--98922090(+) cgtctG/Atacta 2 -- us2k12Minor allele frequency- A:0.00CSA 2
    rs1932941901,2
    --98922139(+) GTAGTC/TCCAGC 2 -- us2k10--------
    rs125394801,2
    C,F,H--98922222(+) actgcG/Actcca 2 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1842641481,2
    --98922243(+) CAGAGA/CAAGGC 2 -- us2k10--------
    rs1895744561,2
    --98922317(+) CTCACC/GTTACA 2 -- us2k10--------
    rs1809449731,2
    --98922368(+) TGGCGC/TTGGGC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARPC1A (98923496 - 98985787 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ARPC1A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5863CNV Insertion18451855
    nsv831068CNV Loss17160897
    nsv831069CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing ARPC1A:
    Pancreatic Cancer
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ARPC1A
    DNA2.0 Custom Variant and Variant Library Synthesis for ARPC1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604220    OMIM disorders: --

    9 diseases for ARPC1A:    
    About MalaCards
    boomerang dysplasia    lattice corneal dystrophy    shigellosis    corneal dystrophy
    crohn's disease    pancreatic cancer    pancreatitis    hiv-1
    malaria


    ARPC1A for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARPC1A
    Human Genome Epidemiology (HuGE) Navigator: ARPC1A (3 documents)

    Export disorders for ARPC1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for ARPC1A gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with ARPC1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fission yeast Sop2p: a novel and evolutionarily conserved protein that interacts with Arp3p and modulates profilin function. (PubMed id 8978670)1, 2, 3 Balasubramanian M.K.... Gould K.L. (EMBO J. 1996)
    2. Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. (PubMed id 21533175)1, 4 Zhai G....Wallaschofski H. (PLoS Genet. 2011)
    3. Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease. (PubMed id 20570966)1, 4 McGovern D.P....Rotter J.I. (Hum. Mol. Genet. 2010)
    4. Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients. (PubMed id 17072959)1, 4 Piepoli A....Perri F. (World J. Gastroenterol. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    7. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PubMed id 9230079)1, 3 Welch M.D.... Mitchison T.J. (J. Cell Biol. 1997)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 10552 HGNC: 703 AceView: ARPC1A Ensembl:ENSG00000241685 euGenes: HUgn10552
    ECgene: ARPC1A Kegg: 10552 H-InvDB: ARPC1A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ARPC1A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ARPC1A gene:
    Search GeneIP for patents involving ARPC1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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