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Aliases for ARPC1A Gene

Aliases for ARPC1A Gene

  • Actin Related Protein 2/3 Complex, Subunit 1A, 41kDa 2 3
  • SOP2-Like Protein 2 3 4
  • SOP2L 3 4 6
  • Actin Binding Protein (Schizosaccharomyces Pombe Sop2-Like) 2 3
  • Actin Related Protein 2/3 Complex, Subunit 1A (41 KD) 2
  • Actin-Related Protein 2/3 Complex Subunit 1A 3
  • Epididymis Luminal Protein 68 3
  • HEL-68 3
  • SOP2Hs 3
  • Arc40 3

External Ids for ARPC1A Gene

Summaries for ARPC1A Gene

Entrez Gene Summary for ARPC1A Gene

  • This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for ARPC1A Gene

ARPC1A (Actin Related Protein 2/3 Complex, Subunit 1A, 41kDa) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and Immune response CCR3 signaling in eosinophils. GO annotations related to this gene include actin binding. An important paralog of this gene is ARPC1B.

UniProtKB/Swiss-Prot for ARPC1A Gene

  • Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks

Gene Wiki entry for ARPC1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARPC1A Gene

Genomics for ARPC1A Gene

Genomic Location for ARPC1A Gene

Start:
99,325,873 bp from pter
End:
99,388,164 bp from pter
Size:
62,292 bases
Orientation:
Plus strand

Genomic View for ARPC1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARPC1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARPC1A Gene

Regulatory Elements for ARPC1A Gene

Proteins for ARPC1A Gene

  • Protein details for ARPC1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92747-ARC1A_HUMAN
    Recommended name:
    Actin-related protein 2/3 complex subunit 1A
    Protein Accession:
    Q92747
    Secondary Accessions:
    • A4D276
    • B4DLQ7
    • D6W5S1
    • Q7Z5U8
    • Q86WU5
    • Q8IXQ0

    Protein attributes for ARPC1A Gene

    Size:
    370 amino acids
    Molecular mass:
    41569 Da
    Quaternary structure:
    • Probable component of the Arp2/3 complex in which it may replace ARPC1B

    Alternative splice isoforms for ARPC1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARPC1A Gene

Proteomics data for ARPC1A Gene at MOPED

Post-translational modifications for ARPC1A Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys63, Lys87, Lys165, and Lys290

Other Protein References for ARPC1A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ARPC1A Gene

Domains for ARPC1A Gene

Gene Families for ARPC1A Gene

HGNC:
  • ARPC :Actin related protein 2/3 complex subunits
  • WDR :WD repeat domain containing

Suggested Antigen Peptide Sequences for ARPC1A Gene

Graphical View of Domain Structure for InterPro Entry

Q92747

UniProtKB/Swiss-Prot:

ARC1A_HUMAN
Family:
  • Belongs to the WD repeat ARPC1 family.:
    • Q92747
Similarity:
  • Contains 6 WD repeats.:
    • Q92747
genes like me logo Genes that share domains with ARPC1A: view

Function for ARPC1A Gene

Molecular function for ARPC1A Gene

UniProtKB/Swiss-Prot Function: Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks

Gene Ontology (GO) - Molecular Function for ARPC1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding TAS 8978670
GO:0005515 protein binding --
GO:0051015 actin filament binding IBA --
genes like me logo Genes that share ontologies with ARPC1A: view

Phenotypes for ARPC1A Gene

GenomeRNAi human phenotypes for ARPC1A:
genes like me logo Genes that share phenotypes with ARPC1A: view

miRNA for ARPC1A Gene

miRTarBase miRNAs that target ARPC1A

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARPC1A Gene

Localization for ARPC1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARPC1A Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARPC1A Gene COMPARTMENTS Subcellular localization image for ARPC1A gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ARPC1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton --
GO:0005885 Arp2/3 protein complex IBA --
GO:0015629 actin cytoskeleton TAS 8978670
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ARPC1A: view

Pathways for ARPC1A Gene

genes like me logo Genes that share pathways with ARPC1A: view

Gene Ontology (GO) - Biological Process for ARPC1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007411 axon guidance TAS --
GO:0030036 actin cytoskeleton organization TAS 8978670
GO:0030833 regulation of actin filament polymerization --
GO:0034314 Arp2/3 complex-mediated actin nucleation IBA --
genes like me logo Genes that share ontologies with ARPC1A: view

Transcripts for ARPC1A Gene

Unigene Clusters for ARPC1A Gene

Actin related protein 2/3 complex, subunit 1A, 41kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARPC1A Gene

No ASD Table

Relevant External Links for ARPC1A Gene

GeneLoc Exon Structure for
ARPC1A
ECgene alternative splicing isoforms for
ARPC1A

Expression for ARPC1A Gene

mRNA expression in normal human tissues for ARPC1A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARPC1A Gene

SOURCE GeneReport for Unigene cluster for ARPC1A Gene Hs.124126

genes like me logo Genes that share expressions with ARPC1A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARPC1A Gene

Orthologs for ARPC1A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARPC1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARPC1A 35
  • 99.55 (n)
  • 100 (a)
ARPC1A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARPC1A 35
  • 91.53 (n)
  • 99.73 (a)
ARPC1A 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARPC1A 35
  • 94.59 (n)
  • 100 (a)
ARPC1A 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arpc1a 35
  • 90.81 (n)
  • 98.65 (a)
Arpc1a 16
Arpc1a 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARPC1A 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARPC1A 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arpc1a 35
  • 90.99 (n)
  • 98.92 (a)
chicken
(Gallus gallus)
Aves ARPC1A 35
  • 83.69 (n)
  • 95.95 (a)
ARPC1A 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARPC1A 36
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia arpc1a-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76015 35
zebrafish
(Danio rerio)
Actinopterygii arpc1a 35
  • 77.66 (n)
  • 90.54 (a)
arpc1a 36
  • 91 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008908 35
  • 57.83 (n)
  • 57.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta Arpc1 35
  • 59.54 (n)
  • 58.97 (a)
Sop2 36
  • 55 (a)
OneToMany
Sop2 37
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea arx-3 35
  • 58.1 (n)
  • 57.82 (a)
arx-3 36
  • 55 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL022W 35
  • 50.93 (n)
  • 43.11 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARC40 35
  • 45.73 (n)
  • 40.63 (a)
ARC40 36
  • 36 (a)
OneToMany
ARC40 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F10615g 35
  • 49.16 (n)
  • 40.95 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02781 35
  • 50.86 (n)
  • 45.14 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arc1 35
  • 52.3 (n)
  • 47.99 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3148 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10119 36
  • 56 (a)
OneToMany
Species with no ortholog for ARPC1A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARPC1A Gene

ENSEMBL:
Gene Tree for ARPC1A (if available)
TreeFam:
Gene Tree for ARPC1A (if available)

Paralogs for ARPC1A Gene

Paralogs for ARPC1A Gene

Selected SIMAP similar genes for ARPC1A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ARPC1A: view

Variants for ARPC1A Gene

Sequence variations from dbSNP and Humsavar for ARPC1A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs14431 -- 99,366,159(-) CTTAA(A/G)GAGAA utr-variant-3-prime
rs740160 -- 99,360,257(+) TGTCT(C/T)GACTG intron-variant
rs956295 -- 99,361,058(+) GTTTA(A/G)AATCT intron-variant
rs1052296 -- 99,366,187(+) TTGTC(A/C)CACTA utr-variant-3-prime
rs2107705 -- 99,329,036(-) GGCGT(A/G)AGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARPC1A Gene

Variant ID Type Subtype PubMed ID
nsv831068 CNV Loss 17160897
nsv5863 CNV Insertion 18451855
nsv831069 CNV Loss 17160897

Relevant External Links for ARPC1A Gene

HapMap Linkage Disequilibrium report
ARPC1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARPC1A Gene

Disorders for ARPC1A Gene

Relevant External Links for ARPC1A

Genetic Association Database (GAD)
ARPC1A
Human Genome Epidemiology (HuGE) Navigator
ARPC1A
genes like me logo Genes that share disorders with ARPC1A: view

No data available for UniProtKB/Swiss-Prot for ARPC1A Gene

Publications for ARPC1A Gene

  1. Fission yeast Sop2p: a novel and evolutionarily conserved protein that interacts with Arp3p and modulates profilin function. (PMID: 8978670) Balasubramanian M.K. … Gould K.L. (EMBO J. 1996) 2 3 4
  2. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PMID: 9230079) Welch M.D. … Mitchison T.J. (J. Cell Biol. 1997) 2 3
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ARPC1A Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Copy Number PCR Panels: for ARPC1A
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ARPC1A
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ARPC1A
    • Block miRNA regulation of ARPC1A using miScript Target Protectors

    Sources for ARPC1A Gene

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