Aliases for ARPC1A Gene
- Actin Related Protein 2/3 Complex Subunit 1A 2 3 5
- SOP2-Like Protein 2 3 4
- Actin Binding Protein (Schizosaccharomyces Pombe Sop2-Like) 2 3
- Actin Related Protein 2/3 Complex Subunit 1A, 41kDa 2 3
- SOP2L 3 4
- Actin Related Protein 2/3 Complex, Subunit 1A (41 KD) 2
- Actin Related Protein 2/3 Complex, Subunit 1A, 41kDa 3
External Ids for ARPC1A Gene
Previous GeneCards Identifiers for ARPC1A Gene
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
GeneCards Summary for ARPC1A Gene
ARPC1A (Actin Related Protein 2/3 Complex Subunit 1A) is a Protein Coding gene. Diseases associated with ARPC1A include Radial Neuropathy and Boomerang Dysplasia. Among its related pathways are Bacterial invasion of epithelial cells and Regulation of actin dynamics for phagocytic cup formation. GO annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is ARPC1B.
UniProtKB/Swiss-Prot for ARPC1A Gene
Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.