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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARPC1A Gene

protein-coding   GIFtS: 60
GCID: GC07P098923

Actin Related Protein 2/3 Complex, Subunit 1A, 41kDa

(Previous names: actin related protein 2/3 complex, subunit 1A (41 kD))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Actin Related Protein 2/3 Complex, Subunit 1A, 41kDa1 2     Actin Related Protein 2/3 Complex, Subunit 1A (41 KD)1
SOP2-Like Protein1 2 3     Arc402
SOP2L2 3 5     SOP2Hs2
Actin Binding Protein (Schizosaccharomyces Pombe Sop2-Like)1 2     Actin-Related Protein 2/3 Complex Subunit 1A2

External Ids:    HGNC: 7031   Entrez Gene: 105522   Ensembl: ENSG000002416857   OMIM: 6042205   UniProtKB: Q927473   

Export aliases for ARPC1A gene to outside databases

Previous GC identifers: GC07P097458 GC07P098521 GC07P098534 GC07P098568 GC07P098761 GC07P093559


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARPC1A Gene:
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2
family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two
proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated
in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling
and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions
of the complex to different cell types or developmental stages. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2010)

GeneCards Summary for ARPC1A Gene: 
ARPC1A (actin related protein 2/3 complex, subunit 1A, 41kDa) is a protein-coding gene. Diseases associated with ARPC1A include boomerang dysplasia, and lattice corneal dystrophy, and among its related super-pathways are Development Slit-Robo signaling and Immune response CCR3 signaling in eosinophils. GO annotations related to this gene include actin binding. An important paralog of this gene is ARPC1B.

UniProtKB/Swiss-Prot: ARC1A_HUMAN, Q92747
Function: Probably functions as component of the Arp2/3 complex which is involved in regulation of actin
polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of
branched actin networks

Gene Wiki entry for ARPC1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARPC1A gene promoter:
         AhR   SREBP-1c   Arnt   SREBP-1b   AREB6   POU2F1   SREBP-1a   POU2F1a   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ARPC1A promoter sequence
   Search SABiosciences Chromatin IP Primers for ARPC1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARPC1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

ARPC1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARPC1A gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P098923:  view genomic region     (about GC identifiers)

Start:
98,923,496 bp from pter      End:
98,985,787 bp from pter
Size:
62,292 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 98,283,446-98,323,834     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARC1A_HUMAN, Q92747 (See protein sequence)
Recommended Name: Actin-related protein 2/3 complex subunit 1A  
Size: 370 amino acids; 41569 Da
Subunit: Probable component of the Arp2/3 complex in which it may replace ARPC1B
Subcellular location: Cytoplasm, cytoskeleton (Probable)
Secondary accessions: A4D276 D6W5S1 Q7Z5U8 Q86WU5 Q8IXQ0

Explore the universe of human proteins at neXtProt for ARPC1A: NX_Q92747

Explore proteomics data for ARPC1A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92747

  • ARPC1A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARPC1A Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001177925.1  NP_006400.2  

    ENSEMBL proteins: 
     ENSP00000412879   ENSP00000262942   ENSP00000408711   ENSP00000408578  
    Reactome Protein details: Q92747
    Human Recombinant Protein Products for ARPC1A: 
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    Cloud-Clone Corp. Proteins for ARPC1A 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton ----
    GO:0015629actin cytoskeleton TAS8978670

    ARPC1A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ARPC: Actin related protein 2/3 complex subunits
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR017383 ARPC2/3_su1
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q92747

    ProtoNet protein and cluster: Q92747

    1 Blocks protein domain: IPB001680 G-protein beta WD-40 repeat signature

    UniProtKB/Swiss-Prot: ARC1A_HUMAN, Q92747
    Similarity: Belongs to the WD repeat ARPC1 family
    Similarity: Contains 6 WD repeats


    ARPC1A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARC1A_HUMAN, Q92747
    Function: Probably functions as component of the Arp2/3 complex which is involved in regulation of actin
    polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of
    branched actin networks

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding ----
         
    ARPC1A for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARPC1A:
     Decreased Tat-dependent transc  Increased peripheral focal adh 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ARPC1A 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ARPC1A About   (see all 15)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development Slit-Robo signaling
    Development Slit-Robo signaling0.92
    Pathogenic Escherichia coli infection0.43
    Cytoskeleton remodeling Slit-Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    2Immune response CCR3 signaling in eosinophils
    Immune response CCR3 signaling in eosinophils0.51
    Inhibitory action of Lipoxins on neutrophil migration0.51
    3Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Integrin-mediated cell adhesion and migration0.49
    Cytoskeleton remodeling Integrin outside-in signaling0.37
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility0.32
    4Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.80
    Fcgamma receptor (FCGR) dependent phagocytosis0.80
    5Immune System
    Immune System0.56
    Innate Immune System0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/13 EMD Millipore Pathways for ARPC1A (see all 13)
        Cytoskeleton remodeling Integrin outside-in signaling
    Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling CDC42 in cellular processes
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Immune response Role of DAP12 receptors in NK cells


    5/14 GeneGo (Thomson Reuters) Pathways for ARPC1A (see all 14)
        Cytoskeleton remodeling CDC42 in cellular processes
    Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling Integrin outside-in signaling

    1 BioSystems Pathway for ARPC1A
        Pathogenic Escherichia coli infection


    4        Reactome Pathways for ARPC1A
        Regulation of actin dynamics for phagocytic cup formation
    Fcgamma receptor (FCGR) dependent phagocytosis
    Immune System
    Innate Immune System


    5/6         Kegg Pathways  (Kegg details for ARPC1A) (see all 6):
        Fc gamma R-mediated phagocytosis
    Regulation of actin cytoskeleton
    Bacterial invasion of epithelial cells
    Pathogenic Escherichia coli infection
    Shigellosis


    ARPC1A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARPC1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/78 Interacting proteins for ARPC1A (Q927473 ENSP000002629424) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTR2P611603, ENSP000003672204I2D: score=7 STRING: ENSP00000367220
    ACTR3BQ9P1U13, ENSP000002560014I2D: score=7 STRING: ENSP00000256001
    AARSD1Q9BTE63I2D: score=3 
    MYO1EQ129653, ENSP000002882354I2D: score=3 STRING: ENSP00000288235
    PTGES3L-AARSD1Q9BTE63I2D: score=3 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030036actin cytoskeleton organization TAS8978670
    GO:0030833regulation of actin filament polymerization IEA--
    GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS--
    GO:0045087innate immune response TAS--

    ARPC1A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARPC1A (ARC1A)

    Search CenterWatch for drugs/clinical trials and news about ARPC1A / ARC1A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARPC1A gene (2 alternative transcripts): 
    NM_001190996.1  NM_006409.3  

    Unigene Cluster for ARPC1A:

    Actin related protein 2/3 complex, subunit 1A, 41kDa
    Hs.124126  [show with all ESTs]
    Unigene Representative Sequence: NM_001190996
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000441989 ENST00000262942(uc003upx.2 uc003upy.2) ENST00000432786
    ENST00000471960 ENST00000463009 ENST00000477240 ENST00000432884(uc011kit.2)

    miRNA
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    Additional mRNA sequence: 

    AB209059.1 AK223015.1 BC006445.1 BC039594.1 BC047889.1 BC054027.1 Y08999.1 

    24/25 DOTS entries (see all 25):

    DT.118915  DT.100854337  DT.100854311  DT.100854339  DT.100854340  DT.99940694  DT.92454422  DT.95278412 
    DT.121054645  DT.121054663  DT.100854326  DT.101970044  DT.121054582  DT.121461824  DT.100768114  DT.100854333 
    DT.121054644  DT.121054662  DT.121462228  DT.92018573  DT.92064363  DT.92454421  DT.95278418  DT.95300095 

    24/653 AceView cDNA sequences (see all 653):

    BQ684654 BU682205 BG024835 BM997441 CB049293 AA018344 BM692682 CR595042 
    AA599290 BU627116 AA761659 BI518623 BQ422409 AA082551 CR613605 BQ684448 
    BU784505 CR621448 AW276179 BE349395 AI086506 BU579636 CF145224 BC047889 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARPC1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAAACTGTG
    ARPC1A Expression
    About this image


    See ARPC1A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARPC1A

    SOURCE GeneReport for Unigene cluster: Hs.124126
        SABiosciences Custom PCR Arrays for ARPC1A
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARPC1A gene from 9/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arpc1a1 , 5 actin related protein 2/3 complex, subunit 1A1, 5 90.81(n)1
    98.65(a)1
      5 (85.00 cM)5
    564431  NM_019767.21  NP_062741.11 
     1450838305 
    chicken
    (Gallus gallus)
    Aves ARPC1A1 actin related protein 2/3 complex, subunit 1A, 41kDa 83.69(n)
    95.95(a)
      770269  NM_001079495.1  NP_001072963.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARPC1A6
    Uncharacterized protein
    95(a)
    1 ↔ 1
    GL343725.1(187661-199313)
    African clawed frog
    (Xenopus laevis)
    Amphibia arpc1a-prov2 actin related protein 2/3 complex, subunit 1A, 41kDa 78.97(n)    BC041267.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arpc1a2 actin related protein 2/3 complex, subunit 1A 79.22(n)   394243  AY398313.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sop21 , 3 actin filament-based process actin
    binding3
    Suppressor of profilin 21
    58(a)3
    59.6(n)1
    59.31(a)1
      34D63
    347931  NM_057248.41  NP_476596.11 
    worm
    (Caenorhabditis elegans)
    Secernentea arx-31 Protein ARX-3 58.12(n)
    57.75(a)
      3565442  NM_067169.3  NP_499570.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARC40(YBR234C)4
    ARC401
    Subunit of the ARP2/3 complex, which is required for more4
    Arc40p1
    45.73(n)1
    40.63(a)1
      2(686592-685438)4
    8525361, 4  NP_009793.11, 4 
    corn
    (Zea mays)
    Liliopsida AY105528.12   -- 71.66(n)    AY105528.1 


    ENSEMBL Gene Tree for ARPC1A (if available)
    TreeFam Gene Tree for ARPC1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARPC1A gene
    ARPC1B2  
    1 SIMAP similar gene for ARPC1A using alignment to 5 protein entries:     ARC1A_HUMAN (see all proteins):
    ARPC1B

    ARPC1A for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for ARPC1A
    PGOHUM00000234760 PGOHUM00000240511 PGOHUM00000238151 PGOHUM00000245618 PGOHUM00000235652


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/844 SNPs in ARPC1A are shown (see all 844)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs69534761,2
    C,F,A,H--98921600(+) tggcaG/Ccagtg 2 -- us2k110Minor allele frequency- C:0.49NA WA CSA EA 370
    rs1474470831,2
    --98921696(+) TTAGAG/TTCTCA 2 -- us2k10--------
    rs570255111,2
    C,F--98921779(+) GCCCCC/TACTGA 2 -- us2k12Minor allele frequency- T:0.11WA 120
    rs1400247521,2
    --98921948(+) CTGCAC/GTAACT 2 -- us2k10--------
    rs102744071,2
    C,A,H--98922090(+) cgtctG/Atacta 2 -- us2k12Minor allele frequency- A:0.00CSA 2
    rs1932941901,2
    --98922139(+) GTAGTC/TCCAGC 2 -- us2k10--------
    rs125394801,2
    C,F,H--98922222(+) actgcG/Actcca 2 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1842641481,2
    --98922243(+) CAGAGA/CAAGGC 2 -- us2k10--------
    rs1895744561,2
    --98922317(+) CTCACC/GTTACA 2 -- us2k10--------
    rs1809449731,2
    --98922368(+) TGGCGC/TTGGGC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARPC1A (98923496 - 98985787 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ARPC1A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv5863CNV Insertion18451855
    nsv831068CNV Loss17160897
    nsv831069CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing ARPC1A:
    Pancreatic Cancer
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ARPC1A
    DNA2.0 Custom Variant and Variant Library Synthesis for ARPC1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604220    OMIM disorders: --

    7 diseases for ARPC1A:    About MalaCards
    boomerang dysplasia    lattice corneal dystrophy    corneal dystrophy    shigellosis
    crohn's disease    pancreatic cancer    pancreatitis


    ARPC1A for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARPC1A
    Human Genome Epidemiology (HuGE) Navigator: ARPC1A (3 documents)

    Export disorders for ARPC1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARPC1A gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with ARPC1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fission yeast Sop2p: a novel and evolutionarily conserved protein that interacts with Arp3p and modulates profilin function. (PubMed id 8978670)1, 2, 3 Balasubramanian M.K.... Gould K.L. (1996)
    2. Eight common genetic variants associated with serum D HEAS levels suggest a key role in ageing mechanisms. (PubMed id 21533175)1, 4 Zhai G....Wallaschofski H. (2011)
    3. Fucosyltransferase 2 (FUT2) non-secretor status is as sociated with Crohn's disease. (PubMed id 20570966)1, 4 McGovern D.P....Rotter J.I. (2010)
    4. Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients. (PubMed id 17072959)1, 4 Piepoli A....Perri F. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    7. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PubMed id 9230079)1, 3 Welch M.D.... Mitchison T.J. (1997)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10552 HGNC: 703 AceView: ARPC1A Ensembl:ENSG00000241685 euGenes: HUgn10552
    ECgene: ARPC1A Kegg: 10552 H-InvDB: ARPC1A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARPC1A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARPC1A gene:
    Search GeneIP for patents involving ARPC1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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