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ARNTL2 Gene

protein-coding   GIFtS: 56
GCID: GC12P027485

Aryl Hydrocarbon Receptor Nuclear Translocator-Like 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Aryl Hydrocarbon Receptor Nuclear Translocator-Like 21 2     PASD92 3
BMAL22 3 5     bHLHe62 3
CLIF2 3 5     CYCLE-Like Factor2 3
Basic-Helix-Loop-Helix-PAS Protein MOP92 3     PAS Domain-Containing Protein 92 3
Brain And Muscle ARNT-Like 22 3     Aryl Hydrocarbon Receptor Nuclear Translocator-Like Protein 22
Class E Basic Helix-Loop-Helix Protein 62 3     Transcription Factor BMAL22
Member Of PAS Protein 92 3     BHLHE63
MOP92 3     

External Ids:    HGNC: 189841   Entrez Gene: 569382   Ensembl: ENSG000000291537   OMIM: 6145175   UniProtKB: Q8WYA13   

Export aliases for ARNTL2 gene to outside databases

Previous GC identifers: GC12P027846 GC12P027497 GC12P027386 GC12P027377 GC12P027255


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARNTL2 Gene:
This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily.
The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to
certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a
transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and
hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of
circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus,
hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been
described for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for ARNTL2 Gene:
ARNTL2 (aryl hydrocarbon receptor nuclear translocator-like 2) is a protein-coding gene. Diseases associated with ARNTL2 include hypoxia, and bipolar i disorder. GO annotations related to this gene include protein dimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ARNT2.

UniProtKB/Swiss-Prot: BMAL2_HUMAN, Q8WYA1
Function: ARNTL2-CLOCK heterodimers activate E-box element (5'-CACGTG-5') transcription. Also, in umbilical vein
endothelial cells, activates SERPINE1 through E-box sites. This transactivation is inhibited by PER2 and CRY1

Gene Wiki entry for ARNTL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_009714.18  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARNTL2 gene promoter:
         RORalpha1   POU2F1   AML1a   Zic1   Bach2   POU2F1a   Chx10   LCR-F1   C/EBPalpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ARNTL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARNTL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.2-p11.2   Ensembl cytogenetic band:  12p11.23   HGNC cytogenetic band: 12p12.2-p11.2

ARNTL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARNTL2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P027485:  view genomic region     (about GC identifiers)

Start:
27,485,787 bp from pter      End:
27,576,241 bp from pter
Size:
90,455 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: BMAL2_HUMAN, Q8WYA1 (See protein sequence)
Recommended Name: Aryl hydrocarbon receptor nuclear translocator-like protein 2  
Size: 636 amino acids; 70887 Da
Subunit: Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARNTL or
ARNTL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with CLOCK to form the
ARNTL2-CLOCK transactivator. Can form heterodimers or homodimers which interact directly with CLOCK to form the
transcription activator. Also interacts with NPAS2 and HIF1A
1 PDB 3D structure from and Proteopedia for ARNTL2:
2KDK (3D)    
Secondary accessions: B7Z429 F5H402 Q8WYA2 Q8WYA3 Q8WYA4 Q96J63 Q9H2M4 Q9NS70 Q9NYQ4 Q9NYQ5
Alternative splicing: 9 isoforms:  Q8WYA1-1   Q8WYA1-2   Q8WYA1-3   Q8WYA1-4   Q8WYA1-5   Q8WYA1-6   Q8WYA1-7   Q8WYA1-8   
Q8WYA1-9   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARNTL2: NX_Q8WYA1

Explore proteomics data for ARNTL2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARNTL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001234931.1  NP_001234932.1  NP_001234933.1  NP_001234934.1  NP_064568.3  

    ENSEMBL proteins: 
     ENSP00000442438   ENSP00000379238   ENSP00000438545   ENSP00000312247   ENSP00000261178  
     ENSP00000266503   ENSP00000400185   ENSP00000445836  
    Reactome Protein details: Q8WYA1

    ARNTL2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    5 InterPro protein domains:
     IPR001610 PAC
     IPR013767 PAS_fold
     IPR000014 PAS
     IPR011598 bHLH_dom
     IPR001067 Nuc_translocat

    Graphical View of Domain Structure for InterPro Entry Q8WYA1

    ProtoNet protein and cluster: Q8WYA1

    5 Blocks protein domains:
    IPB000014 PAS domain
    IPB001067 Nuclear translocator signature
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB001610 PAC motif
    IPB013767 PAS fold


    UniProtKB/Swiss-Prot: BMAL2_HUMAN, Q8WYA1
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain
    Similarity: Contains 1 PAC (PAS-associated C-terminal) domain
    Similarity: Contains 2 PAS (PER-ARNT-SIM) domains


    ARNTL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BMAL2_HUMAN, Q8WYA1
    Function: ARNTL2-CLOCK heterodimers activate E-box element (5'-CACGTG-5') transcription. Also, in umbilical vein
    endothelial cells, activates SERPINE1 through E-box sites. This transactivation is inhibited by PER2 and CRY1
    Induction: Constitutively expressed. Has no circadian rhythm expression pattern

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000982RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity IDA15147242
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity NAS11018023
    GO:0004871signal transducer activity IEA--
    GO:0005515protein binding ----
         
    ARNTL2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARNTL2
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    miRNA
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    miRTarBase miRNAs that target ARNTL2:
    hsa-mir-193b-3p (MIRT016419), hsa-mir-375 (MIRT019814), hsa-mir-192-5p (MIRT026501)

    Block miRNA regulation of human, mouse, rat ARNTL2 using miScript Target Protectors
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARNTL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BMAL2_HUMAN, Q8WYA1: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS11018023
    GO:0005667transcription factor complex IEA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IEA--

    ARNTL2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARNTL2 About    
    See pathways by source

    SuperPathContained pathways About
    1Circadian Clock
    Circadian Clock0.66
    BMAL1-CLOCK/NPAS2 Activates Circadian Expression0.66

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ARNTL2
        BMAL1:CLOCK,NPAS2 activates circadian gene expression



    ARNTL2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including ARNTL2: 
              Circadian Rhythms in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ARNTL2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for ARNTL2 (Q8WYA13 ENSP000002665034) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLOCKO155163, ENSP000003087414I2D: score=3 STRING: ENSP00000308741
    EPAS1Q998143, ENSP000002637344I2D: score=2 STRING: ENSP00000263734
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    SERPINE1ENSP000002230954STRING: ENSP00000223095
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated NAS11018023
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA12055078
    GO:0006366transcription from RNA polymerase II promoter IDA15147242
    GO:0007165signal transduction ----
    GO:0007623circadian rhythm IDA10864977

    ARNTL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARNTL2 (BMAL2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARNTL2 gene (5 alternative transcripts): 
    NM_001248002.1  NM_001248003.1  NM_001248004.1  NM_001248005.1  NM_020183.4  

    Unigene Clusters for ARNTL2:

    Aryl hydrocarbon receptor nuclear translocator-like 2
    Hs.434269  [show with all ESTs], Hs.445447  [show with all ESTs]
    Unigene Representative Sequences: BC043511, NM_020183
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000544915(uc001rht.2 uc001rhu.2 uc001rhv.2 uc001rhw.3 uc010sjp.2 uc009zji.2)
    ENST00000395901 ENST00000546179 ENST00000311001 ENST00000261178 ENST00000266503
    ENST00000457040 ENST00000539558 ENST00000542388
    miRNA
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    GenScript: all cDNA clones in your preferred vector: ARNTL2 (NM_020183)
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      QuantiTect SYBR Green Assays in human, mouse, rat ARNTL2
      QuantiFast Probe-based Assays in human, mouse, rat ARNTL2

    Additional mRNA sequence: 

    AB039921.1 AF231338.1 AF231339.1 AF246960.1 AF246961.1 AF246962.1 AF246963.1 AK296706.1 
    BC000172.3 BC125061.1 BC125062.1 

    10 DOTS entries:

    DT.107836  DT.97837830  DT.65285441  DT.100761003  DT.92420150  DT.95261667  DT.95344098  DT.100760999 
    DT.91705334  DT.92420148 

    8 AceView cDNA sequences:

    BC043511 BU568793 BI832376 CD629896 CD629900 CD629899 CD629895 CD629892 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARNTL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTGTACAGT
    ARNTL2 Expression
    About this image


    ARNTL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Lung (Respiratory System)
             Basal Cells Respiratory Bronchioles
    ARNTL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARNTL2 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.434269 Hs.445447

    UniProtKB/Swiss-Prot: BMAL2_HUMAN, Q8WYA1
    Tissue specificity: Expressed in fetal brain. Highly expressed in brain and placenta. Lower levels in heart,
    liver, thymus, kidney and lung. Located to endothelial cells and neuronal cells of the suprachiasmatic nucleus
    (SCN). Also detected in endothelial cells of the heart, lung and kidney. In the brain, specifically expressed in
    the thalamus, hippocampus and amygdala

        Pathway & Disease-focused RT2 Profiler PCR Array including ARNTL2: 
              Circadian Rhythms in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARNTL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARNTL2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arntl21 , 5 aryl hydrocarbon receptor nuclear translocator-like more1, 5 77.33(n)1
    73.08(a)1
      6 (77.70 cM)5
    2723221  NM_172309.11  NP_758513.11 
     1467960555 
    chicken
    (Gallus gallus)
    Aves ARNTL21 aryl hydrocarbon receptor nuclear translocator-like more 73.49(n)
    69.88(a)
      373925  NM_204133.1  NP_989464.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARNTL26
    aryl hydrocarbon receptor nuclear translocator-lik...
    67(a)
    1 ↔ 1
    5(91339610-91371405)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1420214742   -- 74.52(n)    142021474 
    zebrafish
    (Danio rerio)
    Actinopterygii arntl21 aryl hydrocarbon receptor nuclear translocator-like more 59.64(n)
    55.27(a)
      58099  NM_131578.1  NP_571653.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cyc3 circadian rhythm specific RNA
    polymerase II transcription more
    50(a)   3 76C6   --


    ENSEMBL Gene Tree for ARNTL2 (if available)
    TreeFam Gene Tree for ARNTL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARNTL2 gene
    ARNT22  CLOCK2  NPAS22  AHR2  ARNT2  EPAS12  NPAS32  HIF1A2  
    SIM22  SIM12  HIF3A2  ARNTL2  NPAS12  AHRR2  
    6 SIMAP similar genes for ARNTL2 using alignment to 2 protein entries:     BMAL2_HUMAN (see all proteins):
    ARNTL    CLOCK    NPAS2    ARNT    ARNT2    DKFZp686M216

    ARNTL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARNTL2 (see all 1894)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs113480131,2
    C--27259676(+) GTCACT/-TTTTT 5 -- int11Minor allele frequency- -:0.50NA 2
    rs634014611,2
    C--27289905(+) GTGTG-/TATATAT 5 -- int10--------
    rs123172911,2
    C,F--27289906(+) tgtgtG/Atatat 5 -- int12Minor allele frequency- A:0.50WA CSA 4
    rs350826631,2
    C,F--27299993(+) TACTCTT/-TTATC 5 -- int12Minor allele frequency- -:0.50NA CSA 4
    rs71375881,2
    C,F,A,H--27351543(+) CCGTGG/CTTCCT 5 -- us2k113Minor allele frequency- C:0.17NS EA NA WA 768
    rs110489721,2
    C,F--27351561(+) GATGGA/GCAAAG 5 -- us2k17Minor allele frequency- G:0.09NA EA 250
    rs1142600631,2
    F--27351595(+) TATTTG/TTTCTT 5 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1430774091,2
    --27351771(+) CAAATC/TATCCA 5 -- us2k10--------
    rs781334141,2
    --27351791(+) CTCACA/TTTTTT 5 -- us2k11Minor allele frequency- T:0.01EA 120
    rs2018574611,2
    --27351791(+) TCACA-/TTTTTT 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARNTL2 (27485787 - 27576241 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ARNTL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv271e199CNV Deletion23128226
    esv2745664CNV Deletion23290073
    esv272753CNV Insertion20981092
    esv270213CNV Insertion20981092
    nsv650CNV Insertion18451855
    nsv436825CNV Insertion17901297
    nsv469175CNV Loss19166990
    nsv898940CNV Loss21882294
    nsv832357CNV Gain17160897
    nsv521872CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614517    OMIM disorders: --

    14 diseases for ARNTL2:    
    About MalaCards
    hypoxia    bipolar i disorder    schizoaffective disorder    mood disorder
    fanconi's anemia    bipolar disorder    bronchiolitis    systemic lupus erythematosus
    lupus erythematosus    schizophrenia    parkinson's disease    colorectal cancer
    endotheliitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for ARNTL2:
    Systemic lupus erythematosus

    ARNTL2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARNTL2
    Human Genome Epidemiology (HuGE) Navigator: ARNTL2 (12 documents)

    Export disorders for ARNTL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARNTL2 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with ARNTL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The basic helix-loop-helix-PAS protein MOP9 is a brain-specific heterodimeric partner of circadian and hypoxia factors. (PubMed id 10864977)1, 2, 3 Hogenesch J.B.... Bradfield C.A. (J. Neurosci. 2000)
    2. cDNA cloning of a novel bHLH-PAS transcription factor superfamily gene, BMAL2; Its mRNA expression, subcellular distribution, and chromosomal localization. (PubMed id 10964693)1, 2, 3 Ikeda M.... Nomura M. (Biochem. Biophys. Res. Commun. 2000)
    3. PER2 variantion is associated with depression vulnerability. (PubMed id 19693801)1, 4 Lavebratt C....Forsell Y. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    4. Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. (PubMed id 20554694)1, 4 Kovanen L....Partonen T. (Alcohol Alcohol. 2010)
    5. Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance. (PubMed id 20174623)1, 4 Utge S.J....Paunio T. (PLoS ONE 2010)
    6. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. (PubMed id 20072116)1, 4 Soria V....Urretavizcaya M. (Neuropsychopharmacology 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. (PubMed id 19839995)1, 4 Mansour H.A....Nimgaonkar V.L. (Bipolar Disord 2009)
    9. NPAS2 and PER2 are linked to risk factors of the metabolic syndrome. (PubMed id 19470168)1, 4 Englund A....Partonen T. (J Circadian Rhythms 2009)
    10. Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm. (PubMed id 18228528)1, 4 Shi J....Liu C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56938 HGNC: 18984 AceView: ARNTL2.1 Ensembl:ENSG00000029153 euGenes: HUgn56938
    ECgene: ARNTL2 H-InvDB: ARNTL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ARNTL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ARNTL2 gene:
    Search GeneIP for patents involving ARNTL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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