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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARNTL2 Gene

protein-coding   GIFtS: 50
GCID: GC12P027485

aryl hydrocarbon receptor nuclear translocator-like 2
 Explore 12 diseases affiliated with
ARNTL2 via
MalaCards
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 Human Malady Compendium 
Biological research products
for ARNTL2    

Aliases
for ARNTL2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Aryl Hydrocarbon Receptor Nuclear Translocator-Like 21 2     Class E Basic Helix-Loop-Helix Protein 62 3
BMAL21 2 3     Member Of PAS Protein 92 3
CLIF1 2 3     CYCLE-Like Factor2 3
MOP91 2 3     PAS Domain-Containing Protein 92 3
PASD91 2 3     Aryl Hydrocarbon Receptor Nuclear Translocator-Like Protein 22
BHLHe61     Transcription Factor BMAL22
Basic-Helix-Loop-Helix-PAS Protein MOP92 3     BHLHE63
Brain And Muscle ARNT-Like 22 3     

External Ids:    HGNC: 189841   Entrez Gene: 569382   Ensembl: ENSG000000291537   OMIM: 6145175   UniProtKB: Q8WYA13   

Export aliases for ARNTL2 gene to outside databases

Previous GC identifers: GC12P027846 GC12P027497 GC12P027386 GC12P027377 GC12P027255


Summaries
for ARNTL2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ARNTL2:
This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The
PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain
environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally
active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors,
such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this
protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced
transcript variants encoding different isoforms have been described for this gene. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: BMAL2_HUMAN, Q8WYA1
Function: ARNTL2-CLOCK heterodimers activate E-box element (5'-CACGTG-5') transcription. Also, in umbilical vein
endothelial cells, activates SERPINE1 through E-box sites. This transactivation is inhibited by PER2 and CRY1

Gene Wiki entry for ARNTL2


Genomic Views
for ARNTL2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARNTL2 gene promoter:
         RORalpha1   POU2F1   AML1a   Zic1   Bach2   POU2F1a   Chx10   LCR-F1   C/EBPalpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ARNTL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARNTL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.2-p11.2   Ensembl cytogenetic band:  12p11.23   HGNC cytogenetic band: 12p12.2-p11.2

ARNTL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARNTL2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P027485:  view genomic region     (about GC identifiers)

Start:
 27,485,787 bp from pter      End:
 27,576,241 bp from pter
Size:
 90,455 bases      Orientation:
 plus strand

Proteins
for ARNTL2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BMAL2_HUMAN, Q8WYA1 (See protein sequence)
Recommended Name: Aryl hydrocarbon receptor nuclear translocator-like protein 2  
Size: 636 amino acids; 70887 Da
Subunit: Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARNTL or ARNTL2,
CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with CLOCK to form the ARNTL2-CLOCK
transactivator. Can form heterodimers or homodimers which interact directly with CLOCK to form the transcription
activator. Also interacts with NPAS2 and HIF1A
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for ARNTL2:
2KDK (3D)    
Secondary accessions: B7Z429 F5H402 Q8WYA2 Q8WYA3 Q8WYA4 Q96J63 Q9H2M4 Q9NS70 Q9NYQ4 Q9NYQ5
Alternative splicing: 9 isoforms:  Q8WYA1-1   Q8WYA1-2   Q8WYA1-3   Q8WYA1-4   Q8WYA1-5   Q8WYA1-6   Q8WYA1-7   Q8WYA1-8   
Q8WYA1-9   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARNTL2: NX_Q8WYA1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WYA1

    • ARNTL2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001234931.1  NP_001234932.1  NP_001234933.1  NP_001234934.1  NP_064568.3  

    ENSEMBL proteins: 
     ENSP00000442438   ENSP00000379238   ENSP00000438545   ENSP00000312247   ENSP00000261178  
     ENSP00000266503   ENSP00000400185   ENSP00000445836  

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    Novus Biologicals ARNTL2 Protein
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    Uscn Proteins for ARNTL2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS11018023
    GO:0005667transcription factor complex IEA--
    GO:0005737cytoplasm IEA--


    ARNTL2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ARNTL2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ARNTL2 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR001610 PAC
     IPR013767 PAS_fold
     IPR000014 PAS
     IPR011598 HLH_dom
     IPR001067 Nuc_translocat

    Graphical View of Domain Structure for InterPro Entry Q8WYA1

    ProtoNet protein and cluster: Q8WYA1

    5 Blocks protein families:
    IPB000014 PAS domain
    IPB001067 Nuclear translocator signature
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB001610 PAC motif
    IPB013767 PAS fold


    UniProtKB/Swiss-Prot: BMAL2_HUMAN, Q8WYA1
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain
    Similarity: Contains 1 PAC (PAS-associated C-terminal) domain
    Similarity: Contains 2 PAS (PER-ARNT-SIM) domains


    Function
    for ARNTL2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: BMAL2_HUMAN, Q8WYA1
    Function: ARNTL2-CLOCK heterodimers activate E-box element (5'-CACGTG-5') transcription. Also, in umbilical vein
    endothelial cells, activates SERPINE1 through E-box sites. This transactivation is inhibited by PER2 and CRY1
    Induction: Constitutively expressed. Has no circadian rhythm expression pattern

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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000982RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity IDA15147242
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS11018023
    GO:0004871signal transducer activity IEA--
    GO:0046983protein dimerization activity IEA--


    ARNTL2 for ontologies           About GeneDecksing



    Pathways & Interactions
    for ARNTL2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARNTL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for ARNTL2 (Q8WYA13 ENSP000002665034) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLOCKO155163, ENSP000003087414I2D: score=3 STRING: ENSP00000308741
    EPAS1Q998143, ENSP000002637344I2D: score=2 STRING: ENSP00000263734
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    SERPINE1ENSP000002230954STRING: ENSP00000223095
    NPAS2ENSP000003382834STRING: ENSP00000338283
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent ----
    GO:0006355regulation of transcription, DNA-dependent NAS11018023
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA12055078
    GO:0007623circadian rhythm IDA10864977
    GO:0009649entrainment of circadian clock NAS11018023


    ARNTL2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ARNTL2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARNTL2
    Search CenterWatch for drugs/clinical trials and news about ARNTL2 / BMAL2 

    Transcripts
    for ARNTL2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ARNTL2 gene (5 alternative transcripts): 
    NM_001248002.1  NM_001248003.1  NM_001248004.1  NM_001248005.1  NM_020183.4  

    Unigene Clusters for ARNTL2:

    Aryl hydrocarbon receptor nuclear translocator-like 2
    Hs.434269  [show with all ESTs], Hs.445447  [show with all ESTs]
    Unigene Representative Sequences: BC043511, NM_020183
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000544915(uc001rht.2 uc001rhu.2 uc001rhv.2 uc001rhw.3 uc010sjp.2 uc009zji.2)
    ENST00000395901 ENST00000546179 ENST00000311001 ENST00000261178 ENST00000266503
    ENST00000457040 ENST00000539558 ENST00000542388

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    Clone
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    Additional cDNA sequence: 

    AB039921.1 AF231338.1 AF231339.1 AF246960.1 AF246961.1 AF246962.1 AF246963.1 AK296706.1 
    BC000172.3 BC125061.1 BC125062.1 

    10 DOTS entries:

    DT.107836  DT.97837830  DT.65285441  DT.100761003  DT.92420150  DT.95261667  DT.95344098  DT.100760999 
    DT.91705334  DT.92420148 

    8 AceView cDNA sequences:

    BC043511 BU568793 BI832376 CD629896 CD629900 CD629899 CD629892 CD629895 

    GeneLoc Exon Structure


    Expression
    for ARNTL2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARNTL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTGTACAGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ARNTL2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Line H7 (WA07) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ARNTL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARNTL2

    SOURCE GeneReport for Unigene clusters: Hs.434269 Hs.445447

    UniProtKB/Swiss-Prot: BMAL2_HUMAN, Q8WYA1
    Tissue specificity: Expressed in fetal brain. Highly expressed in brain and placenta. Lower levels in heart, liver,
    thymus, kidney and lung. Located to endothelial cells and neuronal cells of the suprachiasmatic nucleus (SCN). Also
    detected in endothelial cells of the heart, lung and kidney. In the brain, specifically expressed in the thalamus,
    hippocampus and amygdala

        SABiosciences Expression via Pathway-Focused PCR Array including ARNTL2: 
              Circadian Rhythms in human mouse rat

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    In Situ
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    Orthologs
    for ARNTL2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ARNTL2 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ARNTL21 aryl hydrocarbon receptor nuclear translocator-like more 72.93(n)
    68.7(a)    		   373925  NM_204133.1  NP_989464.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ARNTL26
    		 --
    		 67(a)
    		 1 ↔ 1
    		 5(91339750-91367134)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia 1420214742   -- 74.52(n)    142021474 
    zebrafish
    (Danio rerio)    		 Actinopterygii arntl21 aryl hydrocarbon receptor nuclear translocator-like more 59.83(n)
    55.27(a)    		   58099  NM_131578.1  NP_571653.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta cyc3 circadian rhythm specific RNA polymerase II
    transcription more    		 50(a)   3 76C6   --


    ENSEMBL Gene Tree for ARNTL2 (if available)
    TreeFam Gene Tree for ARNTL2 (if available) 

    Paralogs
    for ARNTL2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARNTL2 gene
    ARNT22  CLOCK2  NPAS22  ARNT2  EPAS12  HIF1A2  NPAS32  SIM22  
    SIM12  HIF3A2  ARNTL2  NPAS12  
    6 SIMAP similar genes for ARNTL2 using alignment to 2 protein entries:     BMAL2_HUMAN (see all proteins):
    ARNTL    CLOCK    NPAS2    ARNT    ARNT2    DKFZp686M216

    ARNTL2 for paralogs           About GeneDecksing



    Genomic Variants
    for ARNTL2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1577 NCBI SNPs in ARNTL2 are shown (see all 1577)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs781334141,2
    		--27253219(+) CTCACA/TTTTTT 5 -- us2k11Minor allele frequency- T:0.01EA 120
    rs123191371,2
    		C,F,--27253406(+) GAGAGC/GAAGCA 5 -- us2k14Minor allele frequency- G:0.21WA CSA 124
    rs122995601,2
    		C,F,H,--27253638(+) CACAAT/CAGGAA 5 -- us2k110Minor allele frequency- C:0.16NS NA WA CSA 918
    rs118371971,2
    		H--27253774(+) GTTGTC/GAGGCT 5 -- us2k10--------
    rs123194961,2
    		C,F,H,--27253924(+) CACTTG/TTCTGG 5 -- us2k18Minor allele frequency- T:0.06NS NA WA 914
    rs715243391,2
    		C,F,--27255228(+) GCGCTG/TGGGGC 5 -- int11Minor allele frequency- T:0.33EA 120
    rs759667061,2
    		C,--27255301(+) GGCCG-/AAGCAT 5 -- int10--------
    rs784413021,2
    		--27255712(+) CGCAGG/ATGGGC 5 -- int11Minor allele frequency- A:0.01NA 120
    rs122963051,2
    		C,--27255757(+) CGCAGC/TCCGCT 5 -- int12Minor allele frequency- T:0.19NA WA 120
    rs757689721,2
    		C,F,--27255759(+) CAGCCC/AGCTCC 5 -- int11Minor allele frequency- A:0.05NA 120

    HapMap Linkage Disequilibrium report for ARNTL2 (27485787 - 27576241 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ARNTL2: --

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    Disorders / Diseases
    for ARNTL2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ARNTL2 for disorders           About GeneDecksing

    OMIM gene information: 614517    OMIM disorders: --

    12 diseases for ARNTL2:    About MalaCards
    hypoxia    bipolar i disorder    systemic lupus erythematosus    lupus erythematosus
    schizoaffective disorder    fanconi's anemia    mood disorder    bipolar disorder
    anemia    schizophrenia    neuronitis    alcoholism

    1 disease from the University of Copenhagen DISEASES database for ARNTL2:
    Systemic lupus erythematosus
    Human Genome Epidemiology (HuGE) Navigator: ARNTL2 (12 documents)

    Export disorders for ARNTL2 gene to outside databases

    Publications
    for ARNTL2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARNTL2 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with ARNTL2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The basic helix-loop-helix-PAS protein MOP9 is a brain-specific heterodimeric partner of circadian and hypoxia factors. (PubMed id 10864977)1, 2, 3 Hogenesch J.B.... Bradfield C.A. (2000)
    2. cDNA cloning of a novel bHLH-PAS transcription factor superfamily gene, BMAL2; Its mRNA expression, subcellular distribution, and chromosomal localization. (PubMed id 10964693)1, 2, 3 Ikeda M.... Nomura M. (2000)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Chicken pineal clock genes: implication of BMAL2 as a bidirectional regulator in circadian clock oscillation. (PubMed id 11554928)1, 2 Okano T.... Fukada Y. (2001)
    5. CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression. (PubMed id 11018023)1, 2 Maemura K.... Lee M.-E. (2000)
    6. ARNTL2 and SERPINE1: potential biomarkers for tumor ag gressiveness in colorectal cancer. (PubMed id 22198637)1 Mazzoccoli G....Piepoli A. (2012)
    7. Decreased expression of Bmal2 in patients with Parkin son's disease. (PubMed id 21658431)1 Ding H....Cai Y. (2011)
    8. CLOCK is suggested to associate with comorbid alcohol use and depressive disorders. (PubMed id 20180986)1 SjAPholm L.K....Partonen T. (2010)
    9. PER2 variantion is associated with depression vulnera bility. (PubMed id 19693801)1 Lavebratt C....Forsell Y. (2010)
    10. Circadian clock gene polymorphisms in alcohol use dis orders and alcohol consumption. (PubMed id 20554694)1 Kovanen L....Partonen T. (2010)

    External Searches for ARNTL2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ARNTL2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56938 HGNC: 18984 AceView: ARNTL2.1 Ensembl:ENSG00000029153 euGenes: HUgn56938
    ECgene: ARNTL2 H-InvDB: ARNTL2

    Other Databases showing ARNTL2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ARNTL2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARNTL2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ARNTL2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ARNTL2 gene:
    Search GeneIP for patents involving ARNTL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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