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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ARNTL Gene

protein-coding GIFtS: 61
GCID: GC11P013299

aryl hydrocarbon receptor nuclear translocator-like

Explore 23 diseases affiliated with
ARNTL via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Aryl Hydrocarbon Receptor Nuclear Translocator-Like¹ ²		BHLH-PAS Protein JAP3² ³
BMAL1¹ ² ³ ⁵		PAS Domain-Containing Protein 3² ³
MOP3¹ ² ³		TIC² ⁵
PASD3¹ ² ³		BMAL1c²
BHLHe5¹		ARNT-Like Protein 1, Brain And Muscle²
JAP3¹ ²		Aryl Hydrocarbon Receptor Nuclear Translocator-Like Protein 1²
Basic-Helix-Loop-Helix-PAS Protein MOP3² ³		Basic-Helix-Loop-Helix-PAS Orphan MOP3²
Brain And Muscle ARNT-Like 1² ³		Member Of PAS Superfamily 3²
Class E Basic Helix-Loop-Helix Protein 5² ³		BHLHE5³
Member Of PAS Protein 3² ³

External Ids:	HGNC: 701¹	Entrez Gene: 406²	Ensembl: ENSG00000133794⁷	OMIM: 602550⁵	UniProtKB: O00327³

Export aliases for ARNTL gene to outside databases

Previous GC identifers: GC11P014570 GC11P014048 GC11P013338 GC11P013263 GC11P013255 GC11P012979

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARNTL:

The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This complex

binds an E-box upstream of the PER1 gene, activating this gene and possibly other circadian rhythym-associated genes.

Three transcript variants encoding two different isoforms have been found for this gene. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: BMAL1_HUMAN, O00327

Function: ARNTL-CLOCK heterodimers activate E-box element (5'-CACGTG-3') transcription of a number of proteins of the

circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins (By similarity)

Gene Wiki entry for ARNTL

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ARNTL gene promoter:
CREB p300 deltaCREB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ARNTL promoter sequence

Search SABiosciences Chromatin IP Primers for ARNTL

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARNTL

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15 Ensembl cytogenetic band: 11p15.2 HGNC cytogenetic band: 11p15

ARNTL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARNTL gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P013299: view genomic region (about GC identifiers)

Start:	13,298,199 bp from pter	End:	13,408,813 bp from pter
Size:	110,615 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BMAL1_HUMAN, O00327 (See protein sequence)

Recommended Name: Aryl hydrocarbon receptor nuclear translocator-like protein 1

Size: 626 amino acids; 68762 Da

Subunit: Interacts with CRY2 (By similarity). Component of the circadian clock oscillator which includes the CRY

proteins, CLOCK or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding

requires dimerization with another bHLH protein. Heterodimerization with CLOCK is required for E-box-dependent

transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and ARNTL.

Interaction with PER and CRY proteins requires translocation to the nucleus. Interaction of the CLOCK-ARNTL

heterodimer with PER or CRY inhibits transcription activation. Interacts with HSP90; with AHR in vitro, but not in

vivo. Part of a nuclear complex which also includes GNB2L1/RACK1 and PRKCA; GNB2L1 and PRKCA are recruited to the

complex in a circadian manner

Subcellular location: Nucleus (By similarity)

Miscellaneous: CLOCK-ARNTL double mutations within the PAS domains result in syngernistic desensitization to high

levels of CRY on repression of CLOCK-ARNTL transcriptional activity of PER1 and, disrupt circadian rhythmicity

1 PDB 3D structure from and Proteopedia for ARNTL:

4H10 (3D)

Secondary accessions: A2I2N6 A8K645 B5ME11 B7WPG7 D3DQW6 O00313 O00314 O00315 O00316 O00317 Q4G136

Q8IUT4 Q99631 Q99649

Alternative splicing: 9 isoforms: O00327-2 O00327-1 O00327-3 O00327-4 O00327-5 O00327-6 O00327-7 O00327-8

O00327-9

Explore the universe of human proteins at neXtProt for ARNTL: NX_O00327

Post-translational modifications:

Acetylated on Lys-538 upon dimerization with CLOCK. Acetylation facilitates CRY1-mediated repression (By similarity)¹

Phosphorylated upon dimerization with CLOCK (By similarity)¹

Sumoylated on Lys-259 upon dimerization with CLOCK (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O00327

ARNTL Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001025443.1 NP_001025444.1 NP_001169.3

ENSEMBL proteins:

ENSP00000434044 ENSP00000431566 ENSP00000433540 ENSP00000431488 ENSP00000434263

ENSP00000374357 ENSP00000385915 ENSP00000433571 ENSP00000436313 ENSP00000384517

ENSP00000385581 ENSP00000436721 ENSP00000434781 ENSP00000385897 ENSP00000436442

ENSP00000379718 ENSP00000354278 ENSP00000374358

Reactome Protein details: O00327
Human Recombinant Protein Products:

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	OriGene Purified Proteins (see all 3): ARNTL OriGene Protein Over-expression Lysate (see all 3): ARNTL OriGene Custom Protein Services for ARNTL
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	Novus Biologicals ARNTL Protein Novus Biologicals ARNTL Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ARNTL

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005667	transcription factor complex	IPI	9576906
GO:0005737	cytoplasm	IEA	--
GO:0016604	nuclear body	IEA	--

ARNTL for ontologies About GeneDecksing

ARNTL Antibody Products:

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	Novus Biologicals ARNTL Antibodies
	Abcam antibodies for ARNTL
	Uscn Antibodies for ARNTL
	ThermoFisher Antibody for ARNTL

Assay Products for ARNTL:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ARNTL
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ARNTL

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ARNTL for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR001610 PAC

IPR013767 PAS_fold

IPR000014 PAS

IPR011598 HLH_dom

IPR001067 Nuc_translocat

Graphical View of Domain Structure for InterPro Entry O00327

ProtoNet protein and cluster: O00327

5/6 Blocks protein families (see all 6):

IPB000014 PAS domain

IPB001067 Nuclear translocator signature

IPB001092 Basic helix-loop-helix dimerization domain bHLH

IPB001610 PAC motif

IPB013655 PAS fold-3

UniProtKB/Swiss-Prot: BMAL1_HUMAN, O00327

Similarity: Contains 1 bHLH (basic helix-loop-helix) domain

Similarity: Contains 1 PAC (PAS-associated C-terminal) domain

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: BMAL1_HUMAN, O00327

Function: ARNTL-CLOCK heterodimers activate E-box element (5'-CACGTG-3') transcription of a number of proteins of the

circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins (By similarity)

miRNA Products:		OriGene 3'-UTR Clone (see all 3): ARNTL Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARNTL
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate ARNTL (see all 15):
		hsa-miR-142-3p hsa-miR-203 hsa-miR-3163 hsa-miR-600 hsa-miR-548d-3p hsa-miR-548am hsa-miR-448 hsa-miR-200a

		SwitchGear 3'UTR luciferase reporter plasmid: ARNTL 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARNTL (see all 7) OriGene shRNA RFP: ARNTL OriGene siRNA: ARNTL
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Gene Editing
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		GenScript: all cDNA clones in your preferred vector (see all 3): ARNTL (NM_001030272)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ARNTL
		Search LifeMap BioReagents cell lines for ARNTL

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARNTL

Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000982	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity	ISS	--
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription	IEA	--
GO:0003677	DNA binding	IGI	9576906
GO:0003700	sequence-specific DNA binding transcription factor activity	--	--
GO:0004871	signal transducer activity	IEA	--

ARNTL for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ARNTL:

Increased G2M DNA content

Animal Models:
Mouse knock-outs for ARNTL: Arntl^tm1Bra Arntl^tm1.1Weit
15/18 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Arntl) (see all 18):

adipose tissue	behavior/neurological	cardiovascular system	cellular	embryogenesis
endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism	immune system
integument	mortality/aging	muscle	renal/urinary system	reproductive system

ARNTL for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Phosphorylation and Nuclear Translocation of the BMAL1:CLOCK/NPAS2 Heterodimer

Phosphorylation and Nuclear Translocation of the BMAL1:CLOCK/NPAS2 Heterodimer	1.00	Expression of BMAL1 (ARNTL).	0.33
Circadian Repression of Expression by REV-ERBA	0.75	Metabolic States and Circadian Oscillators	0.30
RORA Activates Circadian Expression	0.33

Circadian rhythm - mammal

	Circadian rhythm - mammal	1.00			Circadian Clock in Mammals	0.40
	Circadian Clock	0.41

Diurnally regulated genes with circadian orthologs

Diurnally regulated genes with circadian orthologs

1.00

Circadian rhythm pathway

Circadian rhythm pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ARNTL

	Metabolic States and Circadian Oscillators
	Circadian Clock in Mammals

2 BioSystems Pathways for ARNTL

	Diurnally regulated genes with circadian orthologs
	Circadian rhythm pathway

5 Reactome Pathways for ARNTL

	Phosphorylation and Nuclear Translocation of the BMAL1:CLOCK/NPAS2 Heterodimer
	Circadian Clock
	Expression of BMAL1 (ARNTL).
	Circadian Repression of Expression by REV-ERBA
	RORA Activates Circadian Expression

1 Kegg Pathway (Kegg details for ARNTL):

Circadian rhythm - mammal

ARNTL for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ARNTL

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/57 Interacting proteins for ARNTL (O00327³ ENSP00000374357⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 57)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CLOCK	O15516³, ENSP00000308741⁴	I2D: score=9 STRING: ENSP00000308741
EPAS1	Q99814³, ENSP00000263734⁴	I2D: score=6 STRING: ENSP00000263734
AHR	P35869³, ENSP00000242057⁴	I2D: score=4 STRING: ENSP00000242057
CRY1	Q16526³, ENSP00000008527⁴	I2D: score=4 STRING: ENSP00000008527
CSNK1E	P49674³, ENSP00000352929⁴	I2D: score=3 STRING: ENSP00000352929

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000060	protein import into nucleus, translocation	IEA	--
GO:0006351	transcription, DNA-dependent	--	--
GO:0006355	regulation of transcription, DNA-dependent	ISS	--
GO:0007623	circadian rhythm	TAS	9616112
GO:0032922	circadian regulation of gene expression	ISS	--

ARNTL for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ARNTL for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ARNTL
5 Novoseek chemical compound relationships for ARNTL gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
arylalkylamine	67.1	1	17645697 (1)
melatonin	52.3	8	18517031 (3), 16306190 (2), 16096739 (1), 17645697 (1) (see all 5)
lipid	0	1	19247803 (1)
nadph	0	2	11441146 (1)
alanine	0	1	15315827 (1)

Search CenterWatch for drugs/clinical trials and news about ARNTL / BMAL1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ARNTL gene (3 alternative transcripts):

NM_001030272.1 NM_001030273.1 NM_001178.4

Unigene Cluster for ARNTL:

Aryl hydrocarbon receptor nuclear translocator-like

Hs.65734 [show with all ESTs]

Unigene Representative Sequence: NM_001030273

18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):

ENST00000529050 ENST00000534544 ENST00000527998 ENST00000533520 ENST00000529825

ENST00000389707(uc001mkp.3 uc001mkr.3) ENST00000401424(uc001mko.3 uc001mks.3)

ENST00000529388 ENST00000530357 ENST00000480685 ENST00000403290 ENST00000403510(uc001mkv.1 uc009ygm.1 uc001mkw.3)

ENST00000482049 ENST00000531665 ENST00000485918 ENST00000403482(uc001mkx.3)

ENST00000497429 ENST00000534102

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		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate ARNTL (see all 15):
		hsa-miR-142-3p hsa-miR-203 hsa-miR-3163 hsa-miR-600 hsa-miR-548d-3p hsa-miR-548am hsa-miR-448 hsa-miR-200a

		SwitchGear 3'UTR luciferase reporter plasmid: ARNTL 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARNTL (see all 7) OriGene shRNA RFP: ARNTL OriGene siRNA: ARNTL
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARNTL

Additional cDNA sequence:

AB000812.1 AB000814.1 AB000815.1 AB000816.1 AF044288.1 AK095749.1 AK291510.1 AK315174.1

BC016674.1 BC031214.1 BC041129.1 U51627.1 U60415.1

15 DOTS entries:

DT.452294 DT.100779799 DT.92072036 DT.100779801 DT.95174579 DT.92476570 DT.100779797 DT.75160044

DT.120743446 DT.120743454 DT.120743461 DT.306098 DT.40132043 DT.95261008 DT.97843394

24/107 AceView cDNA sequences (see all 107):

AW001825 AI139380 BC041129 CA436366 BE045694 AW957136 CA307466 U60415

NM_001178 R13170 AI474036 BM695839 BE893718 BM904813 F09386 F04874

AK095749 F11728 AI648656 BU628193 BC016674 T10128 BM921924 AA348361

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for ARNTL (see all 14) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3	^	4	^	5	^	6a	·	6b	·	6c	·	6d	^	7a	·	7b	^	8	^	9a	·	9b	^	10	^	11	^	12a	·	12b	^	13	^	14a	·	14b	^	15a	·	15b	^
SP1:																							-		-		-				-
SP2:																							-		-		-				-
SP3:													-										-								-
SP4:													-										-		-		-				-
SP5:													-										-		-						-

ExUns:	16	^	17a	·	17b	·	17c	^	18a	·	18b	·	18c	^	19	^	20	^	21	^	22
SP1:									-				-
SP2:									-				-
SP3:									-				-
SP4:									-				-
SP5:									-				-

ECgene alternative splicing isoforms for ARNTL

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ARNTL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGATATTTC

About this image

ARNTL expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Eye

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ARNTL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARNTL

SOURCE GeneReport for Unigene cluster: Hs.65734

UniProtKB/Swiss-Prot: BMAL1_HUMAN, O00327

Tissue specificity: Highly expressed in the adult brain, skeletal muscle and heart

SABiosciences Expression via Pathway-Focused PCR Arrays including ARNTL:

Circadian Rhythms in human mouse rat

Prostate Cancer in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARNTL

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARNTL

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ARNTL gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ARNTL¹	aryl hydrocarbon receptor nuclear translocator-like	82.83(n) 94.24(a)		374115 NM_001001463.1 NP_001001463.1
lizard (Anolis carolinensis)	Reptilia	ARNTL⁶	--	92(a)	1 ↔ 1	GL343237.1(1455769-1479468)
African clawed frog (Xenopus laevis)	Amphibia	Xl.2098²	Xenopus laevis transcribed sequence with weak similarity more	73.86(n)		BG486314.1
zebrafish (Danio rerio)	Actinopterygii	AF144690.1²	--	75.97(n)		58098 AF144690.1
fruit fly (Drosophila melanogaster)	Insecta	cyc^{1 , 3}	circadian rhythm specific RNA polymerase II transcription more³ cycle¹	53(a)³ 54.82(n)¹ 54.82(a)¹		3 76C6³ 40162¹ NM_079444.2¹ NP_524168.2¹

ENSEMBL Gene Tree for ARNTL (if available)
TreeFam Gene Tree for ARNTL (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ARNTL gene

ARNT2² CLOCK² NPAS2² ARNT² EPAS1² HIF1A² NPAS3² SIM2²

SIM1² HIF3A² ARNTL2² NPAS1²

8 SIMAP similar genes for ARNTL using alignment to 12 protein entries: BMAL1_HUMAN (see all proteins):

ARNTL2 NPAS2 ARNT2 CLOCK ARNT AHRR

DKFZp686M216 MLX

ARNTL for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12282253^1,2	C,	--	12978088(+)	`TGTCAA/GTGAGC`	1	--	us2k¹		2		WA	120
rs74718007^1,2	F,	--	12979090(+)	`AGCGCG/TCGCGG`	1	--	us2k¹		1		NA	120
rs72867439^1,2	C,F,	--	12979120(+)	`CGTGCG/ACTCCT`	1	--	us2k¹		1		NA	120
rs11022744^1,2	C	--	12979217(+)	`CACAAC/GTGGCC`	1	--	us2k¹ tfbs³		2		NA	4
rs77896536^1,2	F,	--	12979719(+)	`CTTAAA/TGGGCC`	1	--	ut5¹		1		WA	118
rs12272728^1,2	C,	--	12979895(+)	`CCCACC/AGCCCT`	1	--	ut5¹		2		WA	120
rs75027398^1,2	C,	--	12981425(+)	`TGAAGC/TTGGTT`	1	--	ds500¹		2		WA	120
rs141318791^1,2		--	13297468(+)	`AAAGTC/TTAGTT`	3	--	us2k¹		0	--	--	--	--
rs150825443^1,2		--	13297492(+)	`TGCCAC/TCTACT`	3	--	us2k¹		0	--	--	--	--
rs139229996^1,2		--	13297540(+)	`AGTTTA/CCCCAT`	4	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ARNTL (13298199 - 13408813 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ARNTL
1 CNV: 71284
1 Indel: 71283

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ARNTL for disorders           About GeneDecksing

OMIM gene information: 602550    OMIM disorders: --

20/23 diseases for ARNTL (see all 23):    About MalaCards

bipolar i disorder schizoaffective disorder epithelial ovarian cancer mood disorder

mental disorders bipolar disorder pandas jaundice

ovarian cancer hyperlipidemia parkinson's disease aldosteronism

dementia colorectal cancer breast cancer hypertension

hypoxia prostatitis arthritis schizophrenia

Human Genome Epidemiology (HuGE) Navigator: ARNTL (20 documents)

Export disorders for ARNTL gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ARNTL gene, integrated from 9 sources (see all 151):
(articles sorted by number of sources associating them with ARNTL)

Utopia: connect your pdf to the dynamic
world of online information

cDNA cloning and tissue-specific expression of a novel basic helix- loop-helix/PAS protein (BMAL1) and identification of alternatively spliced variants with alternative translation initiation site usage. (PubMed id 9144434)^{1, 2, 3, 9} Ikeda M. and Nomura M. (1997)
Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. (PubMed id 9079689)^{1, 2, 3} Hogenesch J.B.... Bradfield C.A. (1997)
The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. (PubMed id 9576906)^{1, 2, 9} Hogenesch J.B.... Bradfield C.A. (1998)
Feedback repression is required for mammalian circadian clock function. (PubMed id 16474406)^{1, 2, 9} Sato T.K.... Hogenesch J.B. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Role of the CLOCK protein in the mammalian circadian mechanism. (PubMed id 9616112)^{1, 2} Gekakis N.... Weitz C.J. (1998)
Epigenetic inactivation of the circadian clock gene B MAL1 in hematologic malignancies. (PubMed id 19861541)^{1, 9} Taniguchi H....Esteller M. (2009)
Expression of clock genes Per1 and Bmal1 in total leu kocytes in health and Parkinson's disease. (PubMed id 19912323)^{1, 9} Cai Y....Chan P. (2010)
Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK. (PubMed id 18430226)^{1, 9} Langmesser S....Albrecht U. (2008)
ARNTL (BMAL1) and NPAS2 gene variants contribute to f ertility and seasonality. (PubMed id 20368993)^{1, 9} Kovanen L....Partonen T. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 406	HGNC: 701	AceView: ARNTL	Ensembl:ENSG00000133794	euGenes: HUgn406
ECgene: ARNTL	Kegg: 406	H-InvDB: ARNTL

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ARNTL	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ARNTL gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ARNTL gene:
Search GeneIP for patents involving ARNTL

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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ARNTL Gene

aryl hydrocarbon receptor nuclear translocator-like

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ARNTL (Gene Symbol)
Aryl Hydrocarbon Receptor Nuclear Translocator-Like
BMAL1
MOP3
PASD3
BHLHe5
JAP3
Basic-Helix-Loop-Helix-PAS Protein MOP3
Brain And Muscle ARNT-Like 1
Class E Basic Helix-Loop-Helix Protein 5
Member Of PAS Protein 3
BHLH-PAS Protein JAP3
PAS Domain-Containing Protein 3
TIC
BMAL1c
ARNT-Like Protein 1, Brain And Muscle
Aryl Hydrocarbon Receptor Nuclear Translocator-Like Protein 1
Basic-Helix-Loop-Helix-PAS Orphan MOP3
Member Of PAS Superfamily 3
BHLHE5

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ARNTL Gene

aryl hydrocarbon receptor nuclear translocator-like

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