Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ARNTL Gene

Aliases for ARNTL Gene

  • Aryl Hydrocarbon Receptor Nuclear Translocator-Like 2 3
  • BMAL1 3 4 6
  • Class E Basic Helix-Loop-Helix Protein 5 3 4
  • Basic-Helix-Loop-Helix-PAS Protein MOP3 3 4
  • PAS Domain-Containing Protein 3 3 4
  • Brain And Muscle ARNT-Like 1 3 4
  • Member Of PAS Protein 3 3 4
  • BHLH-PAS Protein JAP3 3 4
  • BHLHe5 3 4
  • PASD3 3 4
  • MOP3 3 4
  • TIC 3 6
  • Aryl Hydrocarbon Receptor Nuclear Translocator-Like Protein 1 3
  • Basic-Helix-Loop-Helix-PAS Orphan MOP3 3
  • ARNT-Like Protein 1, Brain And Muscle 3
  • Member Of PAS Superfamily 3 3
  • BMAL1c 3
  • JAP3 3

External Ids for ARNTL Gene

Previous GeneCards Identifiers for ARNTL Gene

  • GC11P014570
  • GC11P014048
  • GC11P013338
  • GC11P013263
  • GC11P013255
  • GC11P013299
  • GC11P012979

Summaries for ARNTL Gene

Entrez Gene Summary for ARNTL Gene

  • The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for ARNTL Gene

ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator-Like) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include protein heterodimerization activity and bHLH transcription factor binding. An important paralog of this gene is AHRR.

UniProtKB/Swiss-Prot for ARNTL Gene

  • Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots circa (about) and diem (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for timegivers). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5-CACGTG-3) within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK NPAS2-ARNTL/BMAL1 ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. ARNTL/BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway. Plays a role in normal pancreatic beta-cell function; regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NFE2L2/NRF2 and its targets SESN2, PRDX3, CCLC and CCLM. Negatively regulates the mTORC1 signaling pathway; regulates the expression of MTOR and DEPTOR. Controls diurnal oscillations of Ly6C inflammatory monocytes; rhythmic recruitment of the PRC2 complex imparts diurnal variation to chemokine expression that is necessary to sustain Ly6C monocyte rhythms. Regulates the expression of HSD3B2, STAR, PTGS2, CYP11A1, CYP19A1 and LHCGR in the ovary and also the genes involved in hair growth. Plays an important role in adult hippocampal neurogenesis by regulating the timely entry of neural stem/progenitor cells (NSPCs) into the cell cycle and the number of cell divisions that take place prior to cell-cycle exit. Regulates the circadian expression of CIART and KLF11. The CLOCK-ARNTL/BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The NPAS2-ARNTL/BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina.

Gene Wiki entry for ARNTL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARNTL Gene

Genomics for ARNTL Gene

Regulatory Elements for ARNTL Gene

Genomic Location for ARNTL Gene

Start:
13,276,652 bp from pter
End:
13,387,266 bp from pter
Size:
110,615 bases
Orientation:
Plus strand

Genomic View for ARNTL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARNTL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARNTL Gene

Proteins for ARNTL Gene

  • Protein details for ARNTL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00327-BMAL1_HUMAN
    Recommended name:
    Aryl hydrocarbon receptor nuclear translocator-like protein 1
    Protein Accession:
    O00327
    Secondary Accessions:
    • A2I2N6
    • A8K645
    • B5ME11
    • B7WPG7
    • D3DQW6
    • O00313
    • O00314
    • O00315
    • O00316
    • O00317
    • Q4G136
    • Q8IUT4
    • Q99631
    • Q99649

    Protein attributes for ARNTL Gene

    Size:
    626 amino acids
    Molecular mass:
    68762 Da
    Quaternary structure:
    • Component of the circadian clock oscillator which includes the CRY1/2 proteins, CLOCK or NPAS2, ARNTL/BMAL1 or ARNTL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER1/2/3 proteins. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerization with CLOCK is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and ARNTL/BMAL1. Part of a nuclear complex which also includes GNB2L1/RACK1 and PRKCA; GNB2L1 and PRKCA are recruited to the complex in a circadian manner. Interacts with NPAS2, HDDX4, SUMO3, OGT, EED, EZH2, SUZ12, BHLHE40/DEC1, BHLHE41/DEC2, ID1, ID2, ID3, MTA1 and SIRT1. Interacts with RELB and the interaction is enhanced in the presence of CLOCK. Interacts with PER1, PER2, CRY1 and CRY2 and this interaction requires a translocation to the nucleus. Interaction of the CLOCK-ARNTL/BMAL1 heterodimer with PER or CRY inhibits transcription activation. Interaction of the CLOCK-ARNTL/BMAL1 with CRY1 is independent of DNA but with PER2 is off DNA. The CLOCK-ARNTL/BMAL1 heterodimer interacts with GSK3B (By similarity). Interacts with CLOCK, HSP90, CIART, KAT2B and EP300. Interacts with AHR in vitro. Interacts with KDM5A. Interacts with KMT2A in a circadian manner (By similarity). Interacts with PRKCG (By similarity). Interacts with UBE3A (By similarity). Interacts with MAGEL2 (By similarity). Interacts with NCOA2 (By similarity). Interacts with THRAP3 (By similarity).
    Miscellaneous:
    • CLOCK-ARNTL/BMAL1 double mutations within the PAS domains result in synergistic desensitization to high levels of CRY on repression of CLOCK-ARNTL/BMAL1 transcriptional activity of PER1 and, disrupt circadian rhythmicity

    Three dimensional structures from OCA and Proteopedia for ARNTL Gene

    Alternative splice isoforms for ARNTL Gene

neXtProt entry for ARNTL Gene

Proteomics data for ARNTL Gene at MOPED

Post-translational modifications for ARNTL Gene

  • Acetylated on Lys-538 upon dimerization with CLOCK. Acetylation facilitates CRY1-mediated repression. Deacetylated by SIRT1, which may result in decreased protein stabilty.
  • O-glycosylated; contains O-GlcNAc. O-glycosylation by OGT prevents protein degradation by inhibiting ubiquitination. It also stabilizes the CLOCK-ARNTL/BMAL1 heterodimer thereby increasing CLOCK-ARNTL/BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2/3 and CRY1/2.
  • Phosphorylated upon dimerization with CLOCK. Phosphorylation enhances the transcriptional activity, alters the subcellular localization and decreases the stability of the CLOCK-ARNTL/BMAL1 heterodimer by promoting its degradation. Phosphorylation shows circadian variations in the liver with a peak between CT10 to CT14. Phosphorylation at Ser-90 by CK2 is essential for its nuclear localization, its interaction with CLOCK and controls CLOCK nuclear entry.
  • Sumoylated on Lys-259 upon dimerization with CLOCK. Predominantly conjugated to poly-SUMO2/3 rather than SUMO1 and the level of these conjugates undergo rhythmic variation, peaking at CT9-CT12. Sumoylation localizes it exclusively to the PML body and promotes its ubiquitination in the PML body, ubiquitin-dependent proteasomal degradation and the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer.
  • Ubiquitinated, leading to its proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARNTL Gene

Domains for ARNTL Gene

Gene Families for ARNTL Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

Graphical View of Domain Structure for InterPro Entry

O00327

UniProtKB/Swiss-Prot:

BMAL1_HUMAN :
  • O00327
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Contains 1 PAC (PAS-associated C-terminal) domain.
  • Contains 2 PAS (PER-ARNT-SIM) domains.
genes like me logo Genes that share domains with ARNTL: view

Function for ARNTL Gene

Molecular function for ARNTL Gene

UniProtKB/Swiss-Prot EnzymeRegulation: The redox state of the cell can modulate the transcriptional activity of the CLOCK-ARNTL/BMAL1 and NPAS2-ARNTL/BMAL1 heterodimers; NADH and NADPH enhance the DNA-binding activity of the heterodimers.
UniProtKB/Swiss-Prot Function: Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots circa (about) and diem (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for timegivers). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5-CACGTG-3) within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK NPAS2-ARNTL/BMAL1 ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. ARNTL/BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway. Plays a role in normal pancreatic beta-cell function; regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NFE2L2/NRF2 and its targets SESN2, PRDX3, CCLC and CCLM. Negatively regulates the mTORC1 signaling pathway; regulates the expression of MTOR and DEPTOR. Controls diurnal oscillations of Ly6C inflammatory monocytes; rhythmic recruitment of the PRC2 complex imparts diurnal variation to chemokine expression that is necessary to sustain Ly6C monocyte rhythms. Regulates the expression of HSD3B2, STAR, PTGS2, CYP11A1, CYP19A1 and LHCGR in the ovary and also the genes involved in hair growth. Plays an important role in adult hippocampal neurogenesis by regulating the timely entry of neural stem/progenitor cells (NSPCs) into the cell cycle and the number of cell divisions that take place prior to cell-cycle exit. Regulates the circadian expression of CIART and KLF11. The CLOCK-ARNTL/BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The NPAS2-ARNTL/BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina.

Gene Ontology (GO) - Molecular Function for ARNTL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding ISS --
GO:0000982 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity ISS --
GO:0001046 core promoter sequence-specific DNA binding IEA --
GO:0001047 core promoter binding ISS --
GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription IEA --
genes like me logo Genes that share ontologies with ARNTL: view
genes like me logo Genes that share phenotypes with ARNTL: view

Animal Models for ARNTL Gene

MGI Knock Outs for ARNTL:

miRNA for ARNTL Gene

miRTarBase miRNAs that target ARNTL
Targeting motifs for ARNTL Gene
HOMER Transcription Factor Regulatory Elements motif ARNTL
  • Consensus sequence: GNCACGTG Submotif: canonical Cell Type: Liver GeoId: GSE39860

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for ARNTL Gene

Localization for ARNTL Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARNTL Gene

Nucleus. Cytoplasm. Nucleus, PML body. Note=Shuttles between the nucleus and the cytoplasm and this nucleocytoplasmic shuttling is essential for the nuclear accumulation of CLOCK, target gene transcription and the degradation of the CLOCK-ARNTL/BMAL1 heterodimer. The sumoylated form localizes in the PML body. Sequestered to the cytoplasm in the presence of ID2. {ECO:0000250 UniProtKB:Q9WTL8}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARNTL Gene COMPARTMENTS Subcellular localization image for ARNTL gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ARNTL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 24005054
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IPI 9576906
GO:0005737 cytoplasm --
GO:0016604 nuclear body --
genes like me logo Genes that share ontologies with ARNTL: view

Pathways for ARNTL Gene

genes like me logo Genes that share pathways with ARNTL: view

Gene Ontology (GO) - Biological Process for ARNTL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IEA --
GO:0006355 regulation of transcription, DNA-templated ISS --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0007165 signal transduction IEA --
GO:0007283 spermatogenesis ISS --
genes like me logo Genes that share ontologies with ARNTL: view

Compounds for ARNTL Gene

(5) Novoseek inferred chemical compound relationships for ARNTL Gene

Compound -log(P) Hits PubMed IDs
arylalkylamine 67.1 1
melatonin 52.3 8
lipid 0 1
nadph 0 1
alanine 0 1
genes like me logo Genes that share compounds with ARNTL: view

Transcripts for ARNTL Gene

Unigene Clusters for ARNTL Gene

Aryl hydrocarbon receptor nuclear translocator-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARNTL Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - - - - -
SP5: - - - -
SP6: - -
SP7:
SP8: - - - -
SP9:
SP10:
SP11: -
SP12: -
SP13:
SP14: - - - - - -

ExUns: 16 ^ 17a · 17b · 17c ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21 ^ 22
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: - -
SP6: - -
SP7: - -
SP8: -
SP9: -
SP10: - -
SP11:
SP12:
SP13: -
SP14:

Relevant External Links for ARNTL Gene

GeneLoc Exon Structure for
ARNTL
ECgene alternative splicing isoforms for
ARNTL

Expression for ARNTL Gene

mRNA expression in normal human tissues for ARNTL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ARNTL Gene

SOURCE GeneReport for Unigene cluster for ARNTL Gene Hs.65734

mRNA Expression by UniProt/SwissProt for ARNTL Gene

O00327-BMAL1_HUMAN
Tissue specificity: Hair follicles (at protein level). Highly expressed in the adult brain, skeletal muscle and heart.
genes like me logo Genes that share expressions with ARNTL: view

No data available for mRNA differential expression in normal tissues for ARNTL Gene

Orthologs for ARNTL Gene

This gene was present in the common ancestor of animals.

Orthologs for ARNTL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARNTL 35
  • 99.73 (n)
  • 100 (a)
ARNTL 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARNTL 35
  • 94.08 (n)
  • 98.72 (a)
ARNTL 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARNTL 35
  • 92.91 (n)
  • 98.88 (a)
ARNTL 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arntl 35
  • 91.31 (n)
  • 98.4 (a)
Arntl 16
Arntl 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARNTL 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Arntl 35
  • 91.09 (n)
  • 98.4 (a)
chicken
(Gallus gallus)
Aves ARNTL 35
  • 82.83 (n)
  • 94.24 (a)
ARNTL 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARNTL 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2098 35
tropical clawed frog
(Silurana tropicalis)
Amphibia arntl 35
  • 75.55 (n)
  • 89.05 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
arntl1a 36
  • 85 (a)
OneToMany
arntl1b 36
  • 81 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005655 35
  • 54.83 (n)
  • 56.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta cyc 35
  • 56.01 (n)
  • 57.72 (a)
cyc 36
  • 51 (a)
OneToMany
cyc 37
  • 53 (a)
Species with no ortholog for ARNTL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARNTL Gene

ENSEMBL:
Gene Tree for ARNTL (if available)
TreeFam:
Gene Tree for ARNTL (if available)

Paralogs for ARNTL Gene

Paralogs for ARNTL Gene

genes like me logo Genes that share paralogs with ARNTL: view

Variants for ARNTL Gene

Sequence variations from dbSNP and Humsavar for ARNTL Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs719342 -- 13,373,652(+) TAGGC(A/G)TGTGC intron-variant
rs895682 -- 13,323,685(-) GAGCC(A/G)AGATG intron-variant
rs895683 -- 13,323,464(-) aggag(C/T)aaggc intron-variant
rs895684 -- 13,323,438(-) TTTTG(A/T)AGGAA intron-variant
rs895685 -- 13,323,404(-) ATGTT(A/G)GGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARNTL Gene

Variant ID Type Subtype PubMed ID
esv24912 CNV Loss 19812545
esv26686 CNV Gain 19812545

Relevant External Links for ARNTL Gene

HapMap Linkage Disequilibrium report
ARNTL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARNTL Gene

Disorders for ARNTL Gene

Relevant External Links for ARNTL

Genetic Association Database (GAD)
ARNTL
Human Genome Epidemiology (HuGE) Navigator
ARNTL
genes like me logo Genes that share disorders with ARNTL: view

No data available for UniProtKB/Swiss-Prot for ARNTL Gene

Publications for ARNTL Gene

  1. cDNA cloning and tissue-specific expression of a novel basic helix- loop-helix/PAS protein (BMAL1) and identification of alternatively spliced variants with alternative translation initiation site usage. (PMID: 9144434) Ikeda M. … Nomura M. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 23
  2. The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. (PMID: 9576906) Hogenesch J.B. … Bradfield C.A. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4 23
  3. Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors. (PMID: 11441146) Rutter J. … McKnight S.L. (Science 2001) 3 4 23
  4. Histone acetyltransferase-dependent chromatin remodeling and the vascular clock. (PMID: 14645221) Curtis A.M. … McNamara P. (J. Biol. Chem. 2004) 3 4 23
  5. Feedback repression is required for mammalian circadian clock function. (PMID: 16474406) Sato T.K. … Hogenesch J.B. (Nat. Genet. 2006) 3 4 23

Products for ARNTL Gene

Sources for ARNTL Gene

Back to Top

Content