Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ARNT2 Gene

protein-coding GIFtS: 60
GCID: GC15P080696

aryl-hydrocarbon receptor nuclear translocator 2

Explore 8 diseases affiliated with
ARNT2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Aryl-Hydrocarbon Receptor Nuclear Translocator 2¹ ²		ARNT Protein 2² ³
BHLHe1¹		Aryl Hydrocarbon Receptor Nuclear Translocator 2²
KIAA0307¹ ³		BHLHE1³
Class E Basic Helix-Loop-Helix Protein 1² ³

External Ids:	HGNC: 16876¹	Entrez Gene: 9915²	Ensembl: ENSG00000172379⁷	OMIM: 606036⁵	UniProtKB: Q9HBZ2³

Export aliases for ARNT2 gene to outside databases

Previous GC identifers: GC15M076819 GC15P073853 GC15P078272 GC15P078412 GC15P078484 GC15P057454

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARNT2:

This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors.

The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with

the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli.

Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this

complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar

protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins,

suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of

neurogenesis, respectively. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ARNT2_HUMAN, Q9HBZ2

Function: Specifically recognizes the xenobiotic response element (XRE)

Gene Wiki entry for ARNT2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ARNT2 gene promoter:
E2F-4 E2F-3a E2F-5 E2F-2 NF-kappaB S8 E2F E2F-1 Pax-4a NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ARNT2 promoter sequence

Search SABiosciences Chromatin IP Primers for ARNT2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARNT2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24 Ensembl cytogenetic band: 15q25.1 HGNC cytogenetic band: 15q25.1

ARNT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARNT2 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P080696: view genomic region (about GC identifiers)

Start:	80,696,692 bp from pter	End:	80,890,278 bp from pter
Size:	193,587 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ARNT2_HUMAN, Q9HBZ2 (See protein sequence)

Recommended Name: Aryl hydrocarbon receptor nuclear translocator 2

Size: 717 amino acids; 78691 Da

Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer with the aryl hydrocarbon

receptor (AHR) or the SIM1 protein. Interacts with TACC3 (By similarity)

Subcellular location: Nucleus (Potential)

Sequence caution: Sequence=AAH36099.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;

Sequence=BAA20766.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: B4DIS7 O15024 Q8IYC2

Alternative splicing: 2 isoforms: Q9HBZ2-1 Q9HBZ2-2

Explore the universe of human proteins at neXtProt for ARNT2: NX_Q9HBZ2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9HBZ2

ARNT2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055677.3

ENSEMBL proteins:

ENSP00000307479 ENSP00000453651 ENSP00000453792 ENSP00000452961

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: ARNT2 OriGene Protein Over-expression Lysate: ARNT2 OriGene Custom Protein Services for ARNT2
	GenScript Custom Purified and Recombinant Proteins Services for ARNT2
	Novus Biologicals ARNT2 Proteins Novus Biologicals ARNT2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ARNT2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	12239177
GO:0005667	transcription factor complex	IEA	--
GO:0005737	cytoplasm	IEA	--

ARNT2 for ontologies About GeneDecksing

ARNT2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for ARNT2
	GenScript Custom Superior Antibodies Services for ARNT2
	Novus Biologicals ARNT2 Antibodies
	Search for Antibodies for ARNT2 at Abcam
	Uscn Antibodies for ARNT2
	Search ThermoFisher Antibodies for ARNT2

Assay Products for ARNT2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ARNT2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ARNT2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ARNT2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR001610 PAC

IPR013767 PAS_fold

IPR000014 PAS

IPR011598 HLH_dom

IPR001067 Nuc_translocat

Graphical View of Domain Structure for InterPro Entry Q9HBZ2

ProtoNet protein and cluster: Q9HBZ2

5 Blocks protein families:

IPB000014 PAS domain

IPB001067 Nuclear translocator signature

IPB001092 Basic helix-loop-helix dimerization domain bHLH

IPB001610 PAC motif

IPB013655 PAS fold-3

UniProtKB/Swiss-Prot: ARNT2_HUMAN, Q9HBZ2

Similarity: Contains 1 bHLH (basic helix-loop-helix) domain

Similarity: Contains 1 PAC (PAS-associated C-terminal) domain

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ARNT2_HUMAN, Q9HBZ2

Function: Specifically recognizes the xenobiotic response element (XRE)

miRNA Products:		OriGene 3'-UTR Clone: ARNT2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARNT2
		8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate ARNT2 (see all 30):
		hsa-miR-323-3p hsa-miR-34b* hsa-miR-376b hsa-miR-181c hsa-miR-181a-2* hsa-miR-766 hsa-miR-23a hsa-miR-3941

		SwitchGear 3'UTR luciferase reporter plasmid: ARNT2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARNT2 (see all 7) OriGene shRNA RFP: ARNT2 OriGene siRNA: ARNT2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARNT2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ARNT2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARNT2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARNT2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ARNT2 (NM_014862)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARNT2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARNT2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ARNT2
		Search LifeMap BioReagents cell lines for ARNT2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARNT2

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	ISS	--
GO:0004871	signal transducer activity	IEA	--
GO:0017162	aryl hydrocarbon receptor binding	ISS	--
GO:0046982	protein heterodimerization activity	ISS	--

ARNT2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ARNT2:

Cell cycle / mitosis defect

Animal Models:
Mouse knock-outs for ARNT2: Arnt2^tm1Mcs Arnt2^tm1Yfk
5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Arnt2):

cellular

endocrine/exocrine gland

homeostasis/metabolism

mortality/aging

nervous system

ARNT2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Transcription factors in neurogenesis

Transcription factors in neurogenesis

1.00

Renal cell carcinoma

Renal cell carcinoma

1.00

Pathways in cancer

Pathways in cancer

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for ARNT2

Transcription factors in neurogenesis

2 Kegg Pathways (Kegg details for ARNT2):

	Pathways in cancer
	Renal cell carcinoma

ARNT2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ARNT2

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

5/13 Interacting proteins for ARNT2 (Q9HBZ2^{2, 3} ENSP00000307479⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
USP7	Q93009²^,³, ENSP00000343535⁴	MINT-2867865 I2D: score=3 STRING: ENSP00000343535
NPAS4	Q8IUM7³, ENSP00000311196⁴	I2D: score=2 STRING: ENSP00000311196
SIM2	Q14190³, ENSP00000290399⁴	I2D: score=2 STRING: ENSP00000290399
AHR	P35869³, ENSP00000242057⁴	I2D: score=1 STRING: ENSP00000242057
EPAS1	Q99814³, ENSP00000263734⁴	I2D: score=1 STRING: ENSP00000263734

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IDA	12239177
GO:0001701	in utero embryonic development	ISS	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IDA	11782478
GO:0007417	central nervous system development	ISS	--

ARNT2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ARNT2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ARNT2
1 Novoseek chemical compound relationship for ARNT2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
oxygen	10.9	2	11811994 (1), 10873592 (1)

Search CenterWatch for drugs/clinical trials and news about ARNT2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ARNT2 gene:

NM_014862.3

Unigene Cluster for ARNT2:

Aryl-hydrocarbon receptor nuclear translocator 2

Hs.459070 [show with all ESTs]

Unigene Representative Sequence: NM_014862

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000529181(uc002bfq.3) ENST00000303329(uc002bfr.3) ENST00000533983(uc010unm.2 uc002bfs.3)

ENST00000527771 ENST00000525103 ENST00000531595 ENST00000558849 ENST00000525505

miRNA Products:		OriGene 3'-UTR Clone: ARNT2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARNT2
		8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate ARNT2 (see all 30):
		hsa-miR-323-3p hsa-miR-34b* hsa-miR-376b hsa-miR-181c hsa-miR-181a-2* hsa-miR-766 hsa-miR-23a hsa-miR-3941

		SwitchGear 3'UTR luciferase reporter plasmid: ARNT2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARNT2 (see all 7) OriGene shRNA RFP: ARNT2 OriGene siRNA: ARNT2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARNT2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARNT2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARNT2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ARNT2 (NM_014862)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARNT2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARNT2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARNT2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ARNT2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARNT2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARNT2

Additional cDNA sequence:

AB002305.1 AK295763.1 AL110093.1 BC029293.1 BC036099.1 BC051335.1 BX538026.1 BX647212.1

9 DOTS entries:

DT.101981868 DT.216679 DT.100821451 DT.121016476 DT.121016479 DT.100821443 DT.100821445 DT.100821453

DT.121016525

24/204 AceView cDNA sequences (see all 204):

AI633840 AW050840 AW593174 N22010 BM973448 CB156438 BU176478 AL138048

AV725685 AU133084 AL602530 CB153341 Z46000 BF433011 BM665694 BU735782

BC029293 BX478704 BC051335 BC036099 BQ876829 CB152951 AW269362 CA439137

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ARNT2 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14	^	15a	·	15b	^	16	^	17	^	18	^	19	^	20	^	21a	·	21b
SP1:					-		-																		-
SP2:																									-
SP3:
SP4:					-		-
SP5:							-

ECgene alternative splicing isoforms for ARNT2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ARNT2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCCACCTGG

About this image

ARNT2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ARNT2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARNT2

SOURCE GeneReport for Unigene cluster: Hs.459070

SABiosciences Custom PCR Arrays for ARNT2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARNT2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ARNT2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARNT2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARNT2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARNT2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ARNT2 gene from 6/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ARNT2¹	aryl-hydrocarbon receptor nuclear translocator 2	82.45(n) 95.39(a)		415481 XM_413854.3 XP_413854.2
lizard (Anolis carolinensis)	Reptilia	ARNT2⁶	--	85(a)	1 ↔ 1	GL343332.1(569919-621323)
African clawed frog (Xenopus laevis)	Amphibia	AY331399.1²	--	78.29(n)		AY331399.1
zebrafish (Danio rerio)	Actinopterygii	AF219989.1²	--	75.79(n)		64277 AF219989.1
fruit fly (Drosophila melanogaster)	Insecta	tgo³	tracheal system development (sensu Insecta) RNA more	63(a)		85C2 --
worm (Caenorhabditis elegans)	Secernentea	aha-1³	aryl hydrocarbon receptor nuclear translocator	48(a)		I(10202213-10205044) --

ENSEMBL Gene Tree for ARNT2 (if available)
TreeFam Gene Tree for ARNT2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ARNT2 gene

CLOCK² NPAS2² ARNT² EPAS1² HIF1A² NPAS3² SIM2² SIM1²

ARNTL² HIF3A² ARNTL2² NPAS1²

4 SIMAP similar genes for ARNT2 using alignment to 3 protein entries: ARNT2_HUMAN (see all proteins):

DKFZp686M216 ARNT ARNTL ARNTL2

ARNT2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145379118^1,2	C,F,	probable-non-pathogenic	80872845(+)	`AACCAG/TAGTCA`	2	Q H	mis¹		2		NA EU	5873
rs2278703^1,2	C,F,A,H,	--	80694883(-)	`TCACTG/TCCCCC`	1	--	us2k¹		23		EA NS NA WA CSA	3845
rs190313040^1,2		--	80694906(+)	`TTTATA/GGGCTA`	1	--	us2k¹		0	--	--	--	--
rs2278702^1,2	C,F,A,H,	--	80694922(-)	`TCTGGT/AGGCCC`	1	--	us2k¹		26		EA NS NA WA CSA	4258
rs74027756^1,2	C,	--	80695017(+)	`TGGAGT/AGAGTG`	1	--	us2k¹		2		WA	120
rs2278701^1,2	C,F,H,	--	80695115(-)	`ACCCCG/AAAAAG`	1	--	us2k¹		20		EA NS NA CSA WA	3833
rs62008793^1,2	C,F,	--	80695135(+)	`AGAGGC/GTGAAT`	1	--	us2k¹		4		NA EA	244
rs147829036^1,2		--	80695186(+)	`TGATAA/CGGGGC`	1	--	us2k¹		0	--	--	--	--
rs142404991^1,2		--	80695205(+)	`GGGCCA/TTAGCT`	1	--	us2k¹		0	--	--	--	--
rs71455333^1,2	C,	--	80695218(+)	`ACCCTG/-GGTTT`	1	--	us2k¹		1		NA	2

HapMap Linkage Disequilibrium report for ARNT2 (80696692 - 80890278 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ARNT2
1 CNV: 0787

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARNT2

DNA2.0 Custom Variant and Variant Library Synthesis for ARNT2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ARNT2 for disorders           About GeneDecksing

OMIM gene information: 606036    OMIM disorders: --

8 diseases for ARNT2:    About MalaCards

hypoxia orofacial cleft renal cell carcinoma breast cancer

ataxia neuroblastoma carcinoma neuronitis

Human Genome Epidemiology (HuGE) Navigator: ARNT2 (2 documents)

Export disorders for ARNT2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ARNT2 gene, integrated from 9 sources (see all 36):
(articles sorted by number of sources associating them with ARNT2)

Utopia: connect your pdf to the dynamic
world of online information

Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2): structure, gene mapping, polymorphisms, and candidate evaluation for human orofacial clefts. (PubMed id 12210012)^{1, 2, 9} Barrow L.L.... Murray J.C. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis. (PubMed id 11247670)^{1, 3} Wines M.E.... Holdener B.C. (2001)
Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)^{1, 2} Nagase T.... Ohara O. (1997)
Separate necdin domains bind ARNT2 and HIF1alpha and repress transcription. (PubMed id 17826745)^{1, 9} Friedman E.R. and Fan C.M. (2007)
Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cells. (PubMed id 12239177)^{1, 9} Stolze I....Fandrey J. (2002)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Replication and extension of association between commo n genetic variants in SIM1 and human adiposity. (PubMed id 21512513)¹ Swarbrick M.M....Hsueh W.C. (2011)
siRNA-mediated knockdown of aryl hydrocarbon receptor nuclear translocator 2 affects hypoxia-inducible factor-1 regulatory signaling and metabolism in human breast cancer cells. (PubMed id 21945317)¹ Qin X.Y....Sone H. (2011)
Activation of the aryl hydrocarbon receptor reveals d istinct requirements for IL-22 and IL-17 production by human T helper cells. (PubMed id 20706985)¹ Ramirez J.M....Chizzolini C. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9915	HGNC: 16876	AceView: ARNT2	Ensembl:ENSG00000172379	euGenes: HUgn9915
ECgene: ARNT2	Kegg: 9915	H-InvDB: ARNT2

(According to HUGE)
About This Section

HUGE: KIAA0307

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ARNT2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ARNT2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ARNT2 gene:
Search GeneIP for patents involving ARNT2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for ARNT2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARNT2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARNT2
	OriGene Protein Over-expression Lysate for ARNT2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for ARNT2		OriGene 3'-UTR Clone for ARNT2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARNT2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARNT2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for ARNT2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ARNT2		OriGene Custom Protein Services for ARNT2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARNT2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARNT2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARNT2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARNT2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARNT2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARNT2

	GenScript Custom Purified and Recombinant Proteins Services for ARNT2		GenScript cDNA clones with any tag delivered in your preferred vector for ARNT2
	GenScript Custom Assay Services for ARNT2		GenScript Custom Superior Antibodies Services for ARNT2
	GenScript Custom overexpressing Cell Line Services for ARNT2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in ARNT2 promoter
	Search Chromatin IP Primers for ARNT2
	RT² qPCR Primer Assay in human, mouse, rat ARNT2
	Search GNC Networks for ARNT2
	SABiosciences Custom PCR Arrays for ARNT2

Search Tocris compounds for ARNT2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	ARNT2 antibodies
	ARNT2 proteins
	ARNT2 lysates

	Search for Antibodies for ARNT2 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for ARNT2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

ARNT2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for ARNT2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARNT2

	SwitchGear 3'UTR luciferase reporter plasmids for ARNT2
	SwitchGear Promoter luciferase reporter plasmids for ARNT2

Search ThermoFisher Antibodies for ARNT2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARNT2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ARNT2 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

ARNT2 Gene

aryl-hydrocarbon receptor nuclear translocator 2

Aliases
for ARNT2 gene

Summaries
for ARNT2 gene

Genomic Views
for ARNT2 gene

Proteins
for ARNT2 gene

Protein Domains /
Families
for ARNT2 gene

Function
for ARNT2 gene

Pathways & Interactions
for ARNT2 gene

Drugs & Compounds
for ARNT2 gene

Transcripts
for ARNT2 gene

Expression
for ARNT2 gene

Orthologs
for ARNT2 gene

Paralogs
for ARNT2 gene

Genomic Variants
for ARNT2 gene

Disorders / Diseases
for ARNT2 gene

Publications
for ARNT2 gene

External Searches for ARNT2 gene

Genome Databases showing ARNT2 gene

Other Databases showing ARNT2 gene

Specialized Databases showing ARNT2 gene

Intellectual Property
for ARNT2 gene

Products
for ARNT2 gene

View Random Gene

Advanced Search

Export list of displayed genes

ARNT2 Gene

aryl-hydrocarbon receptor nuclear translocator 2

Aliasesfor ARNT2 gene

Summariesfor ARNT2 gene

Genomic Viewsfor ARNT2 gene

Proteinsfor ARNT2 gene

Protein Domains /Familiesfor ARNT2 gene

Functionfor ARNT2 gene

Pathways & Interactionsfor ARNT2 gene

Drugs & Compoundsfor ARNT2 gene

Transcriptsfor ARNT2 gene

Expression for ARNT2 gene

Orthologsfor ARNT2 gene

Paralogsfor ARNT2 gene

Genomic Variantsfor ARNT2 gene

Disorders / Diseasesfor ARNT2 gene

Publicationsfor ARNT2 gene

External Searches for ARNT2 gene

Genome Databases showing ARNT2 gene

Other Databases showing ARNT2 gene

Specialized Databases showing ARNT2 gene

Intellectual Propertyfor ARNT2 gene

Productsfor ARNT2 gene

View Random Gene

Aliases
for ARNT2 gene

Summaries
for ARNT2 gene

Genomic Views
for ARNT2 gene

Proteins
for ARNT2 gene

Protein Domains /
Families
for ARNT2 gene

Function
for ARNT2 gene

Pathways & Interactions
for ARNT2 gene

Drugs & Compounds
for ARNT2 gene

Transcripts
for ARNT2 gene

Expression
for ARNT2 gene

Orthologs
for ARNT2 gene

Paralogs
for ARNT2 gene

Genomic Variants
for ARNT2 gene

Disorders / Diseases
for ARNT2 gene

Publications
for ARNT2 gene

Intellectual Property
for ARNT2 gene

Products
for ARNT2 gene