Aliases for ARNT2 Gene
External Ids for ARNT2 Gene
Previous GeneCards Identifiers for ARNT2 Gene
This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting additional roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. [provided by RefSeq, Dec 2013]
GeneCards Summary for ARNT2 Gene
ARNT2 (Aryl-Hydrocarbon Receptor Nuclear Translocator 2) is a Protein Coding gene. Diseases associated with ARNT2 include hypothalamic insufficiency-secondary microcephaly-visual impairment-urinary anomalies and webb-dattani syndrome. Among its related pathways are Pathways in cancer and Development HGF signaling pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and signal transducer activity. An important paralog of this gene is AHRR.
UniProtKB/Swiss-Prot for ARNT2 Gene
Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function (PubMed:24022475). Specifically recognizes the xenobiotic response element (XRE).