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ARNT Gene

protein-coding GIFtS: 68

GC01M149048

aryl hydrocarbon receptor nuclear translocator
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
BHLHE2 ^³
HIF-1beta ^¹, ²
HIF1B ^²
HIF1BETA ^²
OTTHUMP00000032943 ^²
TANGO ^²
bHLHe2 ^¹, ², ³

Descriptions
ARNT protein ^³
Class E basic helix-loop-helix protein 2 ^³
Dioxin receptor, nuclear translocator ^², ³
HIF-1 beta ^³
Hypoxia-inducible factor 1 beta ^³
aryl hydrocarbon receptor nuclear translocator ^²
hypoxia-inducible factor 1, beta subunit ^²

External Ids
HGNC: 700¹
Entrez Gene: 405²
UniProtKB: P27540³
Ensembl: ENSG00000143437⁷

Search outside databases for aliases for ARNT gene

Previous GC identifers: GC01M148624 GC01M146529 GC01M147557 GC01M147998 GC01M147595

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ARNT:

The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate

in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat

shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons,

results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes

involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to

xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a

protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor

function. The encoded protein has also been identified as the beta subunit of a heterodimeric

transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which

results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Three

alternatively spliced variants encoding different isoforms have been described for this gene.

[provided by RefSeq]

UniProtKB/Swiss-Prot: ARNT_HUMAN, P27540

Function: Required for activity of the Ah (dioxin) receptor. This protein is required for the

ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The

complex then initiates transcription of genes involved in the activation of PAH procarcinogens.

The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive

response to hypoxia

Gene Wiki entry for ARNT (Aryl_hydrocarbon_receptor_nuclear_translocator)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ARNT gene

Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.2 HGNC cytogenetic band: 1q21

ARNT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M149048: (about GC identifiers)

Start:	149,048,810 bp from pter
End:	149,115,815 bp from pter
Size:	67,006 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ARNT_HUMAN, P27540 (See protein sequence)

Recommended Name: Aryl hydrocarbon receptor nuclear translocator

Size: 789 amino acids; 86636 Da

Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer

with AHR, AHRR, HIF1A and EPAS1/HIF2A as well as with other bHLH proteins. Interacts with TACC3

(By similarity). Interacts with NOCA7

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1D7G (3D)

1X0O (3D)

2A24 (3D)

2ARN (3D)

2B02 (3D)

2HV1 (3D)

2K7S (3D)

3F1N (3D)

3F1O (3D)

3F1P (3D)

Secondary accessions: Q5QP39 Q8NDC7

Alternative splicing: 3 isoforms: P27540-1 P27540-2 P27540-3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001659.1 NP_848513.1 NP_848514.1

ENSEMBL proteins:

ENSP00000315637 ENSP00000345426 ENSP00000351407 ENSP00000346372 ENSP00000357971

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (HIF1 beta, ARNT+ARNT2)
	Human Recombinant Proteins from Abnova (ARNT)

OriGene Purified Recombinant Human Protein: ARNT

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	1317062

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Antibodies for ARNT:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of ARNT
	Sigma-Aldrich Antibodies for ARNT
	R&D Systems Antibodies for ARNT
	Cell Signaling Technology (CST) Antibodies for ARNT (HIF1-beta)
	Antibodies from Abcam (HIF1 beta, ARNT+ARNT2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ARNT)
	Novus Biologicals Antibodies for ARNT

Assays for ARNT:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P27540

ProtoNet protein and cluster: P27540

5 Blocks protein families:

IPB000014 PAS domain

IPB001067 Nuclear translocator signature

IPB001092 Basic helix-loop-helix dimerization domain bHLH

IPB001610 PAC motif

IPB013655 PAS fold-3

UniProtKB/Swiss-Prot: ARNT_HUMAN, P27540

Similarity: Contains 1 basic helix-loop-helix (bHLH) domain

Similarity: Contains 1 PAC (PAS-associated C-terminal) domain

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ARNT)
		Millipore RNAi Products for the Analysis of ARNT Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (ARNT)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_178426

Applied Biosystems Silencer® siRNAs for ARNT

Sigma-Aldrich siRNA for ARNT

Sigma-Aldrich shRNA for ARNT

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ARNT
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001668
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001668
untagged cDNA clones in CMV expression vector (see all 3): NM_001668

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001668

UniProtKB/Swiss-Prot: ARNT_HUMAN, P27540

Function: Required for activity of the Ah (dioxin) receptor. This protein is required for the

ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The

complex then initiates transcription of genes involved in the activation of PAH procarcinogens.

The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive

response to hypoxia

Genatlas biochemistry entry for ARNT:

aryl hydrocarbon receptor nuclear translocator,dioxin receptor translocator,constituvely expressed

for activation of genes involved in metabolism,angiogenesis and apoptosis

15/17 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Arnt) (see all 17 ):

	cellular	craniofacial	embryogenesis	endocrine/exocrine gland
growth/size	hematopoietic system	homeostasis/metabolism	immune system	lethality-prenatal/perinatal
liver/biliary system	nervous system	normal	renal/urinary system	reproductive system

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003705	contributes to RNA polymerase II transcription factor activity, enhancer binding	IDA	7539918 8756616
GO:0003713	transcription coactivator activity	TAS	1317062
GO:0004871	signal transducer activity	IEA	--
GO:0017162	aryl hydrocarbon receptor binding	IPI	9079689
GO:0043565	contributes to sequence-specific DNA binding	IDA	7539918

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for ARNT (Your Favorite Gene powered by Ingenuity) (see all 6 )

Hypoxia Signaling in the Cardiovascular System
Aryl Hydrocarbon Receptor Signaling
Renal Cell Carcinoma Signaling
Xenobiotic Metabolism Signaling
HIF1&alpha

GeneDecks ARNT for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ARNT

5/80 Interacting proteins for ARNT (ENSP00000315637³ P27540^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 80 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NCOA7	Q8NI08¹	STRING (score=.728) EBI-80809, EBI-80799
NCOR2	Q9Y618¹	EBI-80809, EBI-80830
SMAD9	O15198²	MINT-62088
AHR	ENSP00000242057³	STRING (score=.999)
EPAS1	ENSP00000263734³	STRING (score=.999)

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5/12 Gene Ontology (GO) biological process terms (links to tree view) (see all 12 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IDA	8756616
GO:0001938	positive regulation of endothelial cell proliferation	IC	8756616
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0007165	signal transduction	IEA	--
GO:0010575	positive regulation vascular endothelial growth factor production	IDA	8756616

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ARNT
10/17 Novoseek chemical compound relationships for ARNT gene (see all 17 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tcdd	85.36	36	11452142 (4), 8396713 (3), 8145729 (3), 9783729 (2) (see all 17)
alpha-naphthoflavone	57.19	6	8034660 (3)
cocl2	55.11	1	11394885 (1)
3-methylcholanthrene	55.09	2	9783729 (1), 11768231 (1)
oxygen	44.99	18	11927290 (1), 18635960 (1), 9822602 (1), 10864977 (1) (see all 16)
hydrocarbons	38.73	6	10409767 (1), 14672759 (1), 9211913 (1), 7526149 (1) (see all 5)
cobalt	33.59	5	14762718 (1), 12752442 (1), 7836384 (1)
benzo(a)pyrene	23.67	3	19428948 (1)
iron	12.19	2	11739637 (1), 10777486 (1)
oligonucleotide	7.25	2	16204079 (1), 10777486 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ARNT)
		Millipore RNAi Products for the Analysis of ARNT Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (ARNT)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_178426

Sigma-Aldrich siRNA for ARNT

Sigma-Aldrich shRNA for ARNT

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001668 NM_178426 NM_178427

REFSEQ mRNAs for ARNT gene (3 alternative transcripts):

NM_001668.2 NM_178426.1 NM_178427.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001668 NM_178426 NM_178427

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001668
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001668
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001668

Additional cDNA sequence:

AB209877.1 AF001307.1 AK290177.1 AK291705.1 AK293027.1 AK304772.1 AK313780.1 AK315812.1

AL834279.1 BC028362.1 BC041121.1 M69238.1

16 DOTS entries:

DT.314972 DT.97775620 DT.99999712 DT.100817994 DT.307072 DT.91775236 DT.95174379 DT.97769983

DT.97805283 DT.100644213 DT.121612109 DT.307073 DT.92015158 DT.95215706 DT.100817997 DT.40128863

24/688 AceView cDNA sequences (see all 688 ):

N40225 CR614321 CA398154 AI637657 AW515464 CA412969 AI624460 CA427214

CD367075 AI433255 BQ010187 AI354599 AI809867 BU623346 CA397425 AL544431

AW148958 AI697689 BI838004 AW103582 AI074346 AI074954 BF724341 BQ130109

highest scoring ESTs for ARNT:

AF001307 M69238 AI768497 AL042842 AL603187 BG718295 BI602601 BM476736 BQ354044 W47196

Unigene Cluster for ARNT:

Aryl hydrocarbon receptor nuclear translocator

Hs.632446 [show with all ESTs]

Unigene Representative Sequence: NM_001668

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ARNT (see all 8 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	^	10	^	11a	·	11b	^	12a	·	12b	·	12c	^	13a	·	13b	^	14	^	15	^	16	^	17	^
SP1:																			-						-										-		-
SP2:							-												-						-										-
SP3:							-												-						-										-
SP4:							-												-						-								-		-		-		-		-		-		-		-		-		-
SP5:							-

ExUns:	18	^	19	^	20	^	21a	·	21b	^	22	^	23a	·	23b	·	23c	·	23d
SP1:
SP2:
SP3:
SP4:	-		-		-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for ARNT

5 Ensembl transcripts including schematic representations:

ENST00000322733 ENST00000342710 ENST00000358595 ENST00000354396 ENST00000368975

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ARNT expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ARNT

¹ / ² / ³

15 probe-sets matching ARNT gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35968_s_at²^{, 3}	U95-A	1	1.00	1.00	0.56	0.93	AF001307	1.00	0.90	0.95	1
52811_at²^{, 3}	U95-B	1	1.00	1.00	0.78	1.14	AI768497	0.80	1.00	0.91	1
35967_at²^{, 3}	U95-A	2	1.00	0.97	0.85	1.07	M69238	1.00	0.90	0.95	1
54673_s_at²^{, 3}	U95-B	2	1.00	0.97	0.72	1.70	AL042842	0.80	1.00	0.91	1
63275_i_at²^{, 3}	U95-C	1	0.67	1.00	0.82	0.25	W47196	0.80	1.00	0.91	1
218221_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL042842	0.80	1.00	0.91	1
230619_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI768497	0.80	1.00	0.91	1
210828_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF001307	1.00	0.90	0.95	1
218222_x_at²^{, 3}	U133-A	2	1.00	0.95	--	--	NM_001668	0.60	1.00	0.82	1
233724_at*²^{, 3}	U133-B	NULL	0.00	0.00	--	--	AL137290	0.20	1.00	0.72	1
218221_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
230619_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210828_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
218222_x_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--
233724_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

GeneDecks ARNT for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.632446
Expression variation in blood from EXPOLDB for ARNT

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ARNT gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ARNT¹	--	aryl hydrocarbon receptor nuclear translocator	93.32(n) 95.44(a)	483185 XM_540303.2 XP_540303.2
chimpanzee (Pan troglodytes)	ARNT¹	--	aryl hydrocarbon receptor nuclear translocator	99.7(n) 99.62(a)	457279 XM_001170422.1 XP_001170422.1
cow (Bos taurus)	ARNT¹	--	aryl hydrocarbon receptor nuclear translocator	93.62(n) 95.82(a)	281010 NM_173993.1 NP_776418.1
rat (Rattus norvegicus)	Arnt¹	--	aryl hydrocarbon receptor nuclear translocator	89.04(n) 91.5(a)	25242 NM_012780.1 NP_036912.1
mouse (Mus musculus)	Arnt^{1, 5}	3 (47.90 cM)⁵	aryl hydrocarbon receptor nuclear translocator^{1, 5}	89.69(n)¹ 91.89(a)¹	11863¹ NM_001037737.1¹ NP_001032826.1¹ AA959037⁵ AK028546⁵ (see all 19)

About this table Species with no ortholog for ARNT

ENSEMBL Gene Tree for ARNT

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ARNT gene

ARNT2² ARNTL² ARNTL2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/357 NCBI SNPs in ARNT are shown (see all 357 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 100)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs7515228^1,2	C,F,H	149116483(+)	`TAAACT/ATCACA`	3	--	ng3¹		10	EU EA WA NS MN CSAM	948
	rs10305751^1,2	C,F,H	149050082(-)	`TAGCCG/ATCCCA`	3	--	ut3¹ ese³		11	NS EU EA WA	1046
	rs10305741^1,2	C,F,H	149056488(-)	`AGAGAT/GGGACT`	3	E/D	mis¹ int¹		15	NS EU EA WA	1470
	rs7517566^1,2	C,F,H	149116659(+)	`GCAATG/AGATGA`	3	--	ng3¹		19	EU EA WA NS NA MN CSAM	1592
	rs2275237^1,2	C,F,H	149052435(-)	`AGCTCC/TTGAGA`	3	P/L	mis¹ int¹ ese³		9	EA EU WA	2310
	rs2229175^1,2	C,F,H	149062399(-)	`GTTCCG/AGTCTA`	3	Q/R	mis¹ int¹ ese³		10	MN CSAM EA EU WA	880
--	rs10305645^1,2	C,F	149117529(-)	`GAAAAT/-GGAAG`	3	--	ng3¹		1	NS	170
--	rs11552229^1,2	C,F	149050609(-)	`GAAACA/GTGTGA`	3	--	ut3¹		3	NA	142
	rs10305649^1,2	F,H	149115727(-)	`GTTCGG/TTGGCG`	3	--	ut5¹ ese³		5	NS EU EA WA	592
	rs10305755^1,2	F,H	149049666(-)	`TAGTCA/GTAGGG`	3	--	ut3¹ ese³		5	NS EU EA WA	586

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HapMap Linkage Disequilibrium images for ARNT (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 126110

10/14 Novoseek disease relationships for ARNT gene (see all 14 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
endometriosis	21.70	9	16084889 (4), 10724351 (2), 11452142 (1), 11393538 (1) (see all 5)
tumors	16.30	6	11457733 (1), 19145330 (1), 11309328 (1), 19339211 (1) (see all 5)
cancer	13.03	2	11457733 (1), 15479785 (1)
breast cancer	8.44	6	11309328 (3), 16567799 (1), 12761348 (1)
carcinoma	4.63	2	10928066 (1)
inflammation	4.15	1	15884793 (1)
solid tumor	2.87	1	9223322 (1)
shock	0.00	3	8396713 (2), 9498548 (1)
gastric cancer	0.00	5	19287200 (2), 15199114 (1)
ovarian cancer	0.00	1	11756572 (1)

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Genetic Association Database: ARNT
Human Genome Epidemiology Navigator: ARNT (14 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/304 PubMed articles for ARNT gene (see all 304 ):

The aryl hydrocarbon receptor nuclear translocator gene polymorphism in patients with recurrent miscarriage. (PubMed id 16364012)^{1, 3, 6} Sullivan A.E....Silver R.M. (2006)
Analysis of the AhR, ARNT, and AhRR gene polymorphisms: genetic contribution to endometriosis susceptibility and severity. (PubMed id 16084889)^{1, 3, 6} Tsuchiya M.... Ikenoue T. (2005)
Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor. (PubMed id 1317062)^{1, 3, 4} Reyes H.... Hankinson O. (1992)
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. (PubMed id 7539918)^{1, 3, 4} Wang G.L.... Semenza G.L. (1995)
Human arylhydrocarbon receptor repressor (AHRR) gene: genomic structure and analysis of polymorphism in endometriosis. (PubMed id 11393538)^{1, 3, 6} Watanabe T....Inazawa J. (2001)
Characterization of the aryl hydrocarbon receptor repressor gene and association of its Pro185Ala polymorphism with micropenis. (PubMed id 11835227)^{3, 6} Fujita H....Kosaki K. (2002)
Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex. (PubMed id 10395741)^{3, 4} Nguyen T.A.... Safe S. (1999)
Cloning of a factor required for activity of the Ah (dioxin) receptor. (PubMed id 1852076)^{3, 4} Hoffman E.C.... Hankinson O. (1991)
The aryl hydrocarbon receptor nuclear transporter is modulated by the SUMO-1 conjugation system. (PubMed id 12354770)^{1, 3} Tojo M....Nakao M. (2002)
Aryl hydrocarbon receptor nuclear translocator (ARNT) gene as a positional and functional candidate for type 2 diabetes and prediabetic intermediate traits: Mutation detection, case-control studies, and gene expression analysis. (PubMed id 18366646)^{1, 3} Das S.K....Elbein S.C. (2008)

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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 405	HGNC: 700	AceView: CTSKandARNT	Ensembl:ENSG00000143437	euGenes: HUgn405
ECgene: ARNT	H-InvDB: ARNT

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ARNT	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/arnt/

Licensable Technologies for ARNT
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ARNT:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ARNT-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ARNT		Antibodies for ARNT
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ARNT		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ARNT)
	Antibodies (ARNT)
	Chimera RNAi (ARNT)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for ARNT (HIF1-beta)

	Recombinant Proteins (HIF1 beta, ARNT+ARNT2)
	Antibodies (HIF1 beta, ARNT+ARNT2)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for ARNT

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ARNT

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Random Gene From GIFtS :

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ARNT Gene at Home site.
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ARNT Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for ARNT

Summaries
for ARNT

Genomic Location
for ARNT

Proteins
for ARNT

Protein Domains/
Families
for ARNT

Gene Function
for ARNT

Pathways & Interactions
for ARNT

Drugs & Compounds
for ARNT

Transcripts
for ARNT

Expression
for ARNT

Orthologs
for ARNT

Paralogs
for ARNT

SNPs/Variants
for ARNT

Disorders & Mutations
for ARNT

Medical News
for ARNT

Publications
for ARNT

Search for ARNT

Genome Databases showing ARNT

Other Databases showing ARNT

Specialized Databases showing ARNT

Licensable Technologies
for ARNT

Services
for ARNT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ARNT Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor ARNT

Summariesfor ARNT

Genomic Locationfor ARNT

Proteinsfor ARNT

Protein Domains/Familiesfor ARNT

Gene Functionfor ARNT

Pathways & Interactionsfor ARNT

Drugs & Compoundsfor ARNT

Transcriptsfor ARNT

Expression for ARNT

Orthologsfor ARNT

Paralogsfor ARNT

SNPs/Variantsfor ARNT

Disorders & Mutationsfor ARNT

Medical Newsfor ARNT

Publicationsfor ARNT

Search for ARNT

Genome Databases showing ARNT

Other Databases showing ARNT

Specialized Databases showing ARNT

Licensable Technologiesfor ARNT

Servicesfor ARNT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ARNT

Summaries
for ARNT

Genomic Location
for ARNT

Proteins
for ARNT

Protein Domains/
Families
for ARNT

Gene Function
for ARNT

Pathways & Interactions
for ARNT

Drugs & Compounds
for ARNT

Transcripts
for ARNT

Expression
for ARNT

Orthologs
for ARNT

Paralogs
for ARNT

SNPs/Variants
for ARNT

Disorders & Mutations
for ARNT

Medical News
for ARNT

Publications
for ARNT

Licensable Technologies
for ARNT

Services
for ARNT