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Aliases for ARNT Gene

Aliases for ARNT Gene

  • Aryl Hydrocarbon Receptor Nuclear Translocator 2 3 5
  • Class E Basic Helix-Loop-Helix Protein 2 3 4
  • Dioxin Receptor, Nuclear Translocator 3 4
  • HIF-1-Beta 3 4
  • HIF1-Beta 3 4
  • BHLHe2 3 4
  • Hypoxia-Inducible Factor 1, Beta Subunit 3
  • Hypoxia-Inducible Factor 1-Beta 4
  • ARNT Protein 4
  • HIF-1beta 3
  • HIF1BETA 3
  • HIF1B 3
  • TANGO 3

External Ids for ARNT Gene

Previous GeneCards Identifiers for ARNT Gene

  • GC01M148624
  • GC01M146529
  • GC01M147557
  • GC01M147998
  • GC01M147595
  • GC01M149048
  • GC01M122159

Summaries for ARNT Gene

Entrez Gene Summary for ARNT Gene

  • This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]

GeneCards Summary for ARNT Gene

ARNT (Aryl Hydrocarbon Receptor Nuclear Translocator) is a Protein Coding gene. Diseases associated with ARNT include hypoxia. Among its related pathways are Cellular Senescence and HIF-1-alpha transcription factor network. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIF3A.

UniProtKB/Swiss-Prot for ARNT Gene

  • Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.

Gene Wiki entry for ARNT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARNT Gene

Genomics for ARNT Gene

Regulatory Elements for ARNT Gene

Promoters for ARNT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARNT on UCSC Golden Path with GeneCards custom track

Genomic Location for ARNT Gene

Chromosome:
1
Start:
150,809,705 bp from pter
End:
150,876,768 bp from pter
Size:
67,064 bases
Orientation:
Minus strand

Genomic View for ARNT Gene

Genes around ARNT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARNT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARNT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARNT Gene

Proteins for ARNT Gene

  • Protein details for ARNT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27540-ARNT_HUMAN
    Recommended name:
    Aryl hydrocarbon receptor nuclear translocator
    Protein Accession:
    P27540
    Secondary Accessions:
    • B2R9H1
    • C4AMA1
    • F8WAP6
    • Q59ED4
    • Q5QP39
    • Q8NDC7

    Protein attributes for ARNT Gene

    Size:
    789 amino acids
    Molecular mass:
    86636 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with AHR, AHRR, HIF1A and EPAS1/HIF2A as well as with other bHLH proteins. Interacts with TACC3 (By similarity). Interacts with NOCA7. Heterodimer with HIF1A.
    SequenceCaution:
    • Sequence=BAD93114.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD38953.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARNT Gene

    Alternative splice isoforms for ARNT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARNT Gene

Proteomics data for ARNT Gene at MOPED

Post-translational modifications for ARNT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for ARNT (ARNT/HIF-1 beta)
  • Cell Signaling Technology (CST) Antibodies for ARNT (ARNT)

No data available for DME Specific Peptides for ARNT Gene

Domains & Families for ARNT Gene

Gene Families for ARNT Gene

Graphical View of Domain Structure for InterPro Entry

P27540

UniProtKB/Swiss-Prot:

ARNT_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Contains 1 PAC (PAS-associated C-terminal) domain.
  • Contains 2 PAS (PER-ARNT-SIM) domains.
genes like me logo Genes that share domains with ARNT: view

Function for ARNT Gene

Molecular function for ARNT Gene

GENATLAS Biochemistry:
aryl hydrocarbon receptor nuclear translocator,dioxin receptor translocator,constituvely expressed for activation of genes involved in metabolism,angiogenesis and apoptosis
UniProtKB/Swiss-Prot Function:
Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.

Gene Ontology (GO) - Molecular Function for ARNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9704006
GO:0008134 transcription factor binding IPI 7539918
genes like me logo Genes that share ontologies with ARNT: view
genes like me logo Genes that share phenotypes with ARNT: view

Animal Models for ARNT Gene

MGI Knock Outs for ARNT:

Animal Model Products

Transcription Factor Targets for ARNT Gene

Selected GeneGlobe predicted Target genes for ARNT
Targeted motifs for ARNT Gene
HOMER Transcription Factor Regulatory Elements motif ARNT
  • Consensus sequence: TBGCACGCAA Submotif: canonical Cell Type: MCF7

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for ARNT Gene

Localization for ARNT Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARNT Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARNT Gene COMPARTMENTS Subcellular localization image for ARNT gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ARNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090575 RNA polymerase II transcription factor complex IDA 7539918
genes like me logo Genes that share ontologies with ARNT: view

Pathways & Interactions for ARNT Gene

genes like me logo Genes that share pathways with ARNT: view

SIGNOR curated interactions for ARNT Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ARNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IDA 8756616
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030154 cell differentiation IEA --
GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress IDA 8089148
GO:0045648 positive regulation of erythrocyte differentiation IC 1448077
genes like me logo Genes that share ontologies with ARNT: view

Drugs & Compounds for ARNT Gene

(13) Drugs for ARNT Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(12) Additional Compounds for ARNT Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ARNT: view

Transcripts for ARNT Gene

Unigene Clusters for ARNT Gene

Aryl hydrocarbon receptor nuclear translocator:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARNT Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - - - - - - - - -
SP5: -
SP6: - - -
SP7: -
SP8:

ExUns: 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b · 23c · 23d
SP1:
SP2:
SP3:
SP4: - - - -
SP5:
SP6:
SP7:
SP8:

Relevant External Links for ARNT Gene

GeneLoc Exon Structure for
ARNT
ECgene alternative splicing isoforms for
ARNT

Expression for ARNT Gene

mRNA expression in normal human tissues for ARNT Gene

Protein differential expression in normal tissues from HIPED for ARNT Gene

This gene is overexpressed in Placenta (19.7), Heart (13.1), Ovary (9.6), and Blymphocyte (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARNT Gene



SOURCE GeneReport for Unigene cluster for ARNT Gene Hs.632446

genes like me logo Genes that share expression patterns with ARNT: view

Protein tissue co-expression partners for ARNT Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARNT Gene

Orthologs for ARNT Gene

This gene was present in the common ancestor of animals.

Orthologs for ARNT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARNT 36
  • 100 (a)
OneToOne
ARNT 35
  • 99.7 (n)
  • 99.61 (a)
cow
(Bos Taurus)
Mammalia ARNT 36
  • 96 (a)
OneToOne
ARNT 35
  • 93.62 (n)
  • 95.82 (a)
dog
(Canis familiaris)
Mammalia ARNT 35
  • 93.32 (n)
  • 95.44 (a)
ARNT 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arnt 16
Arnt 35
  • 89.69 (n)
  • 91.89 (a)
Arnt 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARNT 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARNT 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arnt 35
  • 89.04 (n)
  • 91.5 (a)
chicken
(Gallus gallus)
Aves ARNT 35
  • 76.36 (n)
  • 80.95 (a)
ARNT 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARNT 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arnt 35
  • 71.6 (n)
  • 75.17 (a)
zebrafish
(Danio rerio)
Actinopterygii arnt 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta tgo 37
  • 62 (a)
tgo 36
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea aha-1 36
  • 48 (a)
OneToMany
aha-1 37
  • 47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2012 36
  • 50 (a)
OneToMany
Species with no ortholog for ARNT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARNT Gene

ENSEMBL:
Gene Tree for ARNT (if available)
TreeFam:
Gene Tree for ARNT (if available)

Paralogs for ARNT Gene

Paralogs for ARNT Gene

genes like me logo Genes that share paralogs with ARNT: view

Variants for ARNT Gene

Sequence variations from dbSNP and Humsavar for ARNT Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs955156 -- 150,865,632(+) TTTAC(C/T)CTCTG intron-variant
rs1268831 -- 150,841,287(+) CTTAA(A/G)AATTC intron-variant
rs1272965 -- 150,877,235(+) ccagt(C/T)tgggc upstream-variant-2KB
rs2089081 -- 150,827,641(-) tttgt(A/G)cacag intron-variant
rs2089082 -- 150,827,614(-) TCATA(A/C)TAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARNT Gene

Variant ID Type Subtype PubMed ID
nsv872418 CNV Gain 21882294
nsv437169 CNV Loss 16327808
nsv2788 CNV Loss 18451855
nsv872420 CNV Loss 21882294
esv5926 CNV Gain 19470904
nsv2810 CNV Loss 18451855

Variation tolerance for ARNT Gene

Residual Variation Intolerance Score: 6.64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.16; 39.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARNT Gene

HapMap Linkage Disequilibrium report
ARNT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARNT Gene

Disorders for ARNT Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARNT Gene - From: GeneCards

Disorder Aliases PubMed IDs
hypoxia
- elite association - COSMIC cancer census association via MalaCards
Search ARNT in MalaCards View complete list of genes associated with diseases

Relevant External Links for ARNT

Genetic Association Database (GAD)
ARNT
Human Genome Epidemiology (HuGE) Navigator
ARNT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARNT
genes like me logo Genes that share disorders with ARNT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARNT Gene

Publications for ARNT Gene

  1. Aryl hydrocarbon receptor nuclear translocator (ARNT) gene as a positional and functional candidate for type 2 diabetes and prediabetic intermediate traits: Mutation detection, case-control studies, and gene expression analysis. (PMID: 18366646) Das S.K. … Elbein S.C. (BMC Med. Genet. 2008) 3 23 48 67
  2. HIF-1beta determines ABCA1 expression under hypoxia in human macrophages. (PMID: 19828131) Ugocsai P. … Schmitz G. (Int. J. Biochem. Cell Biol. 2010) 3 23
  3. Epidermal growth factor-activated aryl hydrocarbon receptor nuclear translocator/HIF-1{beta} signal pathway up-regulates cyclooxygenase-2 gene expression associated with squamous cell carcinoma. (PMID: 19203995) Chang K.Y. … Chen B.K. (J. Biol. Chem. 2009) 3 23
  4. Regulation of glucose metabolism-related genes and VEGF by HIF-1alpha and HIF-1beta, but not HIF-2alpha, in gastric cancer. (PMID: 19287200) Song I.S. … Kim N.S. (Exp. Mol. Med. 2009) 3 23
  5. Glucose and endoplasmic reticulum calcium channels regulate HIF-1beta via presenilin in pancreatic beta-cells. (PMID: 18174159) Dror V. … Johnson J.D. (J. Biol. Chem. 2008) 3 23

Products for ARNT Gene

Sources for ARNT Gene

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