ARNT Gene protein-coding GIFtS : 68 GCID: GC01 M150782
Aryl Hydrocarbon Receptor Nuclear Translocator
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Aliasesfor ARNT gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
and/or 15 RNAdb )About This Section Aliases Aryl Hydrocarbon Receptor Nuclear Translocator 1 2 HIF1B2 Class E Basic Helix-Loop-Helix Protein 22 3 HIF1BETA2 Dioxin Receptor, Nuclear Translocator2 3 TANGO2 HIF-1-beta2 3 Hypoxia-Inducible Factor 1, Beta Subunit2 HIF1-beta2 3 BHLHE23 bHLHe22 3 ARNT Protein3 HIF-1beta2 Hypoxia-Inducible Factor 1-Beta3
Export aliases for ARNT gene to outside databases Previous GC identifers: GC01M148624 GC01M146529 GC01M147557 GC01M147998 GC01M147595 GC01M149048 GC01M122159
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Summariesfor ARNT gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ARNT Gene: The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobioticmetabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding ofligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of theligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs throughbinding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for theseenzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required forreceptor function. The encoded protein has also been identified as the beta subunit of a heterodimerictranscription factor, hypoxia-inducible factor 1. A t(1;12)(q21;p13) translocation, which results in a TEL-ARNTfusion protein, is associated with acute myeloblastic leukemia. Alternative splicing results in multipletranscript variants. (provided by RefSeq, Oct 2010) GeneCards Summary for ARNT Gene: ARNT (aryl hydrocarbon receptor nuclear translocator) is a protein-coding gene. Diseases associated with ARNT include hypoxia estrogen-receptor negative breast cancer related super-pathways are Cellular response to hypoxia and Metabolism of xenobiotics by cytochrome P450 . GO annotations related to this gene include protein heterodimerization activity and sequence-specific DNA binding transcription factor activity . An important paralog of this gene is ARNT2 . UniProtKB/Swiss-Prot: ARNT_HUMAN, P27540 Function : Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-bindingsubunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiatestranscription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A orEPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia Gene Wiki entry for ARNT (Aryl hydrocarbon receptor nuclear translocator) Gene
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Genomic Viewsfor ARNT gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 73) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NT_004487.19 NC_018912.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ARNT gene promoter:AP-1 ATF-2 c-Jun C/EBPalpha Other transcription factors Search SABiosciences Chromatin IP Primers for ARNT Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21 ARNT Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M150782: view genomic region
(about GC identifiers )
Start: 150,782,181 bp from pter End:
150,849,244 bp from pter
Size: 67,064 bases Orientation:
minus strand
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Proteinsfor ARNT gene
(According to
UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MAXQB
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Cloud-Clone Corp. ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Cloud-Clone Corp. ,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
LSBio ,
Abcam , and/or
Cloud-Clone Corp. )
About This Section UniProtKB/Swiss-Prot: ARNT_HUMAN, P27540 See
protein sequence )Recommended Name: Size : 789 amino acids; 86636 DaSubunit : Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with AHR,AHRR, HIF1A and EPAS1/HIF2A as well as with other bHLH proteins. Interacts with TACC3 (By similarity). Interactswith NOCA7. Heterodimer with HIF1A
Subcellular location : NucleusSequence caution : Sequence=CAD38953.1; Type=Erroneous initiation; Note=Translation N-terminally extended;6/16 PDB 3D structures from (see all 16 ):1D7G (3D) 1X0O (3D) 2A24 (3D) 2ARN (3D) 2B02 (3D) 2HV1 (3D) Secondary accessions : C4AMA1 Q5QP39 Q8NDC7Alternative splicing : 3 isoforms : P27540-1 P27540-2 P27540-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ARNT: NX_P27540 Explore proteomics data for ARNT at MOPED Post-translational modifications:
View modification sites using PhosphoSitePlus View neXtProt modification sites for NX_P27540 ARNT Protein expression data from MOPED1 2 3 : About this image REFSEQ proteins (3 alternative transcripts): NP_001184254.1 NP_001659.1 NP_848514.1 ENSEMBL proteins: ENSP00000351407 ENSP00000425899 ENSP00000346372 ENSP00000423851 ENSP00000427571 ENSP00000425363 Reactome Protein details: P27540 Human Recombinant Protein Products for ARNT: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing ARNT Antibody Products: Assay Products for ARNT:
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Protein
Domains /for ARNT gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section HGNC Gene Families: bHLH: Basic helix-loop-helix proteins 5/6 InterPro protein domains (see all 6 ):
Graphical View of Domain Structure for InterPro Entry P27540 ProtoNet protein and cluster: P27540
5 Blocks protein domains : IPB000014 IPB001067 IPB001092 IPB001610 IPB013655 UniProtKB/Swiss-Prot: ARNT_HUMAN, P27540 Similarity : Contains 1 bHLH (basic helix-loop-helix) domainSimilarity : Contains 1 PAC (PAS-associated C-terminal) domainSimilarity : Contains 2 PAS (PER-ARNT-SIM) domainsAbout GeneDecksing
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Functionfor ARNT gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
genOway ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
Vector BioLabs ,
and Sirion Biotech ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: ARNT_HUMAN, P27540 Function : Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-bindingsubunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiatestranscription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A orEPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia
Genatlas biochemistry entry for ARNT aryl hydrocarbon receptor nuclear translocator,dioxin receptor translocator,constituvely expressed for activationof genes involved in metabolism,angiogenesis and apoptosis Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000989 transcription factor binding transcription factor activity
-- -- GO:0003677 DNA binding
-- -- GO:0003700 sequence-specific DNA binding transcription factor activity
TAS 10777486 GO:0003705 contributes to RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIDA 7539918 GO:0003713 transcription coactivator activity
IEA --
About GeneDecksing Phenotypes: 15/17 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Arnt) (see all 17 ):About GeneDecksing Animal Models: MGI mouse knock-outs for ARNT: Arnt tm1.2Gonz Arnt tm1Mcs Arnt tm1Oha Cell Line GenScript Custom overexpressing Cell Line Services for ARNT Search LifeMap BioReagents cell lines for ARNT In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARNT
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Pathways & Interactionsfor ARNT gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene) .
About This Section SuperPaths for ARNT About (see all 20 ) See pathways by source SuperPath Contained pathways About 1 Cellular response to hypoxia 2 Drug metabolism - cytochrome P450 3 Translation Insulin regulation of translation 4 Development PDGF signaling via STATs and NF-kB 5 Signaling events mediated by VEGFR1 and VEGFR2
Pathways by source See SuperPaths Show all pathways 3 2 2 3 5/7 (see all 7 )4 1 ARNT 4 (Kegg details for ARNT) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARNT STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/111 Interacting proteins for ARNT (P27540 1 , 2 , 3 ENSP00000351407 4 via UniProtKB, MINT, STRING , and/or I2D (see all 111 )Interactant Interaction Details GeneCard External ID(s) AHR P35869 1 , 3 ENSP00000242057 4 EBI-80809,EBI-80780 I2D:
score=10 STRING: ENSP00000242057 SMAD9 O15198 2 , 3 MINT-62088 I2D:
score=3 HIF1A Q16665 1 , 3 ENSP00000338018 4 EBI-80809,EBI-447269 I2D:
score=12 STRING: ENSP00000338018 NCOA7 Q8NI08 1 , 3 ENSP00000357341 4 EBI-80809,EBI-80799 I2D:
score=1 STRING: ENSP00000357341 NCOR2 Q9Y618 1 , 3 ENSP00000348551 4 EBI-80809,EBI-80830 I2D:
score=2 STRING: ENSP00000348551
About this table Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20 ): About this table
About GeneDecksing
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Drugs & Compoundsfor ARNT gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek ,
Ligands according to IUPHAR ,
and Drugs according to DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for ARNT 10/25 Novoseek inferred chemical compound relationships for ARNT gene (see all 25 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
tcdd
85
36
11452142 (4), 8396713 (3), 8145729 (3), 9783729 (2) (see
all 17 )
vegf
63.1
40
9950871 (5), 19020709 (4), 20122829 (2), 19287200 (2) (see
all 17 )
alpha-naphthoflavone
56.3
6
8034660 (3)
3-methylcholanthrene
54
2
9783729 (1), 11768231 (1)
cocl2
54
1
11394885 (1)
oxygen
44.8
18
11927290 (1), 18635960 (1), 9822602 (1), 10864977 (1) (see
all 16 )
geldanamycin
38
3
10409767 (2)
beta-naphthoflavone
37.2
1
11595506 (1)
hydrocarbons
36.8
6
10409767 (1), 14672759 (1), 9211913 (1), 7526149 (1) (see
all 5 )
benzo(a)pyrene
34.4
5
19539049 (1), 19428948 (1)
ARNT
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Transcriptsfor ARNT gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , KenesGroup ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Sirion Biotech ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ARNT gene (4 alternative transcripts): NM_001197325.1 NM_001668.3 NM_178427.2 NM_178426.1 Unigene Cluster for ARNT:
Aryl hydrocarbon receptor nuclear translocator Hs.632446 [show with all ESTs ] Unigene Representative Sequence: NM_001668 12 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000358595 (uc010pck.2 uc001evr.2 uc001evs.2 uc009wmd.2 uc009wmb.2 uc009wmc.2 uc009wme.2 uc010pcl.2 )ENST00000471844 ENST00000354396 ENST00000515192 ENST00000505755 ENST00000510273 ENST00000478972 ENST00000512296 ENST00000468970 ENST00000497108 ENST00000505979 ENST00000504358 Primer human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat
Additional mRNA sequence: AB209877.1 AF001307.1 AK290177.1 AK291705.1 AK293027.1 AK304772.1 AK313780.1 AK315812.1 AL834279.1 BC028362.1 BC041121.1 M69238.1
16 DOTS entries : DT.314972 DT.97775620
DT.99999712 DT.100817994 DT.100817997 DT.307072 DT.91775236 DT.95174379 DT.97769983 DT.97805283 DT.100644213 DT.121612109 DT.307073 DT.92015158 DT.95215706 DT.40128863 24/688 AceView cDNA sequences (see all 688 ):
BE466622 CA413729 CK823703 AW149301 CA441772 AI470663 AW196744 AW577517 AA468880 BU948385 AI090277 AI379501 AL542246 CD367075 AA013462 BU740218 AL547908 BU623346 AA588426 AA653814 BQ548724 BM725764 AI433255 AI650987 GeneLoc Exon Structure 5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ARNT (see all 8 ) About this scheme ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ SP1 : - - - - SP2 : - - - - SP3 : - - - - SP4 : - - - - - - - - - - - - - SP5 : -
ExUns: 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b · 23c · 23d SP1 : SP2 : SP3 : SP4 : - - - - SP5 :
ECgene alternative splicing isoforms for ARNT
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Expression for ARNT gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ARNT expression in normal human tissues
(normalized intensities) ARNT embryonic expression: see See probesets specificity/sensitivity at GeneAnnot About this image BioGPS 2/3 CGAP TAG: -- About this image
ARNT expression in embryonic tissues and stem cells About this table LifeMap ,
the Embryonic Development and Stem Cells Database 5/29 selected tissues (see all 29 ) fully expand See ARNT Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ARNT SOURCE GeneReport for Unigene cluster: Hs.632446 SABiosciences Expression via Pathway-Focused PCR Arrays including ARNT (see all 9 ): Primer human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARNT
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Orthologsfor ARNT gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for ARNT gene from 7/16 species (see all 16 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Arnt1 5
aryl hydrocarbon receptor nuclear translocator1, 5
89.69(n) 1 91.89(a) 1
3 (40.74 cM) 5 11863 1 NM_001037737.2 1 NP_001032826.1 1 95434388 5
chicken Aves ARNT1
aryl hydrocarbon receptor nuclear translocator
76.49(n) 81.34(a)
374026 NM_204200.1 NP_989531.1
lizard Reptilia ARNT6
aryl hydrocarbon receptor nuclear translocator
79(a)
1 ↔ 1
GL343893.1(6854-47998)
African clawed frog Amphibia BC061940.12
--
78.84(n)
BC061940.1
zebrafish Actinopterygii arnt6
aryl hydrocarbon receptor nuclear translocator
56(a)
1 ↔ 1
16(5510608-5554436)
fruit fly Insecta tgo1 3
tracheal system development (sensumore 3 1
62(a) 3 54.57(n) 1 50.48(a) 1
85C23 41084 1 NM_169254.1 1 NP_731308.1 1
worm Secernentea aha-11 3
aryl hydrocarbon receptor nuclear3 1
47(a) 3 53.44(n) 1 51.09(a) 1
I(10202213-10205044)3 172889 1 NM_060286.3 1 NP_492687.1 1
ENSEMBL Gene Tree for ARNT (if available)TreeFam Gene Tree for ARNT (if available)
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Paralogsfor ARNT gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ARNT gene ARNT2 2 CLOCK 2 NPAS2 2 EPAS1 2 NPAS3 2 HIF1A 2 SIM2 2 SIM1 2 HIF3A 2 ARNTL 2 NPAS1 2 ARNTL2 2 6 SIMAP similar genes for ARNT using alignment to 9 protein entries: ARNT_HUMAN (see all proteins ):DKFZp686M216 ARNT2 NPAS2 ARNTL2 ARNTL CLOCK About GeneDecksing
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Genomic Variantsfor ARNT gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 1 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for ARNT (150782181 - 150849244 bp)
Structural Variations Database of Genomic Variants (DGV) 6 variations for ARNT : About this table SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing ARNT
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Disorders
/ Diseasesfor ARNT gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Conferences by KenesGroup ,
Novoseek , Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section OMIM gene information: 126110
OMIM disorders : --20/35 (see all 35 ): About MalaCards hypoxia estrogen-receptor negative breast cancer neuromuscular disease endometriosis insulinoma leukemia vitiligo pituitary adenoma esophageal adenocarcinoma cytochrome p450 gastric cancer retinoblastoma infertility acute lymphoblastic leukemia lymphoblastic leukemia breast cancer hypertension adenoma endotheliitis neuroblastoma About GeneDecksing Congresses - knowledge worth sharing: Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015 10/14 Novoseek inferred disease relationships for ARNT gene (see all 14 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
endometriosis
19.5
9
16084889 (4), 10724351 (2), 11452142 (1), 11393538 (1) (see
all 5 )
tumors
15.8
6
11457733 (1), 19145330 (1), 11309328 (1), 19339211 (1) (see
all 5 )
cancer
14.1
2
11457733 (1), 15479785 (1)
breast cancer
8.75
6
11309328 (3), 16567799 (1), 12761348 (1)
carcinoma
4.5
2
10928066 (1)
gastric cancer
3.05
6
19287200 (2), 15199114 (1), 19738050 (1)
solid tumor
0.498
1
9223322 (1)
leukemia
0
2
16547490 (1), 14766942 (1)
herpes simplex
0
1
10545212 (1)
shock
0
3
8396713 (2), 9498548 (1)
Genetic Association Database (GAD): ARNT Human Genome Epidemiology (HuGE) Navigator: ARNT (34 documents) Export disorders for ARNT gene to outside databases
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Publicationsfor ARNT gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ARNT gene, integrated from 9 sources (see all 364 ):(articles sorted by number of sources associating them with ARNT) Utopia : connect your pdf to the dynamic
Aryl hydrocarbon receptor nuclear translocator (ARNT) gene as a positional and functional candidate for type 2 diabetes and prediabetic intermediate traits: Mutation detection, case-control studies, and gene expression analysis. (PubMed id 18366646) 1 , 4, 9(2008) The contribution of genetic variations of aryl hydrocarbon receptor pathway genes to male factor infertility. (PubMed id 17559847) 1 , 4, 9(2007) The aryl hydrocarbon receptor nuclear translocator gene polymorphism in patients with recurrent miscarriage. (PubMed id 16364012) 1 , 4, 9(2006) Analysis of the AhR, ARNT, and AhRR gene polymorphisms: genetic contribution to endometriosis susceptibility and severity. (PubMed id 16084889) 1 , 4, 9(2005) Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor. (PubMed id 1317062) 1 , 2 , 9(1992) Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. (PubMed id 7539918) 1 , 2 , 9(1995) Human arylhydrocarbon receptor repressor (AHRR) gene: genomic structure and analysis of polymorphism in endometriosis. (PubMed id 11393538) 1 , 4, 9(2001) Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168) 1 , 4(2010) Genetic Variation in the Bioactivation Pathway for Po lycyclic Hydrocarbons and Heterocyclic Amines in Relation to Risk of Colorectal Neoplasia. (PubMed id 21081473) 1 , 4(2010) Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891) 1 , 4(2010)
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About This Section Patent Information for ARNT gene: ARNT GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ARNT gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , LSBio , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Sirion Biotech , Cell lines from GenScript , and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory ,
genOway )About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARNT QIAGEN SeqTarget long-range PCR primers for resequencing ARNT QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for ARNT
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARNT
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ARNT
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