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Aliases for ARMT1 Gene

Aliases for ARMT1 Gene

  • Acidic Residue Methyltransferase 1 2 3 4 5
  • C6orf211 3 4
  • Protein-Glutamate O-Methyltransferase 3
  • Chromosome 6 Open Reading Frame 211 2
  • UPF0364 Protein C6orf211 3
  • EC 2.1.1.- 4

External Ids for ARMT1 Gene

Previous HGNC Symbols for ARMT1 Gene

  • C6orf211

Summaries for ARMT1 Gene

GeneCards Summary for ARMT1 Gene

ARMT1 (Acidic Residue Methyltransferase 1) is a Protein Coding gene. GO annotations related to this gene include enzyme binding and protein carboxyl O-methyltransferase activity.

UniProtKB/Swiss-Prot for ARMT1 Gene

  • O-methyltransferase that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Methylates PCNA, suggesting it is involved in the DNA damage response.

Additional gene information for ARMT1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARMT1 Gene

Genomics for ARMT1 Gene

Regulatory Elements for ARMT1 Gene

Enhancers for ARMT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H151497 1.4 FANTOM5 Ensembl ENCODE 11.2 +46.5 46544 3.2 ELF3 FOXA2 ARID4B DMAP1 RAD21 RARA YY1 CREM MIXL1 THAP11 RMND1 ARMT1 RNU6-813P CCDC170 ZBTB2 GC06M151579
GH06H151492 1.2 FANTOM5 ENCODE 11.3 +41.8 41846 2.4 ELF3 TBP FOXA2 ZSCAN4 ARID4B SIN3A DMAP1 ZSCAN9 HMG20B ZNF680 RMND1 CCDC170 HSPA8P15 ZBTB2 ARMT1 ESR1 GC06M151579
GH06H151501 1 Ensembl ENCODE 10.6 +49.9 49910 1.8 SOX13 FOXA2 TEAD1 NFIA JUN HMG20A JUND RCOR2 TCF7 FOSL2 RMND1 ARMT1 CCDC170 GC06M151579
GH06H151399 0.7 ENCODE 11.4 -52.3 -52268 1.3 SMARCE1 RFX1 DPF2 FOXA1 ZNF217 CTBP1 GATA3 ZNF316 MTA1 FOS RMND1 ARMT1 AKAP12 ZBTB2 HSPA8P15
GH06H151413 0.5 ENCODE 11.6 -38.2 -38189 0.9 LEF1 RBAK MAFK RMND1 HSPA8P15 ZBTB2 ARMT1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARMT1 on UCSC Golden Path with GeneCards custom track

Promoters for ARMT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000205316 43 3000 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610 GLIS1

Genomic Locations for ARMT1 Gene

Genomic Locations for ARMT1 Gene
17,844 bases
Plus strand

Genomic View for ARMT1 Gene

Genes around ARMT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARMT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARMT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARMT1 Gene

Proteins for ARMT1 Gene

  • Protein details for ARMT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein-glutamate O-methyltransferase
    Protein Accession:
    Secondary Accessions:
    • Q96FC6
    • Q9UFY5

    Protein attributes for ARMT1 Gene

    441 amino acids
    Molecular mass:
    51172 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARMT1 Gene

Post-translational modifications for ARMT1 Gene

Other Protein References for ARMT1 Gene

No data available for DME Specific Peptides for ARMT1 Gene

Domains & Families for ARMT1 Gene

Gene Families for ARMT1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARMT1 Gene


Suggested Antigen Peptide Sequences for ARMT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ARMT1 family.
  • Belongs to the ARMT1 family.
genes like me logo Genes that share domains with ARMT1: view

Function for ARMT1 Gene

Molecular function for ARMT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate methyl ester.
UniProtKB/Swiss-Prot Function:
O-methyltransferase that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Methylates PCNA, suggesting it is involved in the DNA damage response.

Enzyme Numbers (IUBMB) for ARMT1 Gene

Phenotypes From GWAS Catalog for ARMT1 Gene

Gene Ontology (GO) - Molecular Function for ARMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25732820
GO:0008168 methyltransferase activity IEA --
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity IDA 25732820
GO:0016740 transferase activity IEA --
GO:0019899 enzyme binding IPI 25732820
genes like me logo Genes that share ontologies with ARMT1: view
genes like me logo Genes that share phenotypes with ARMT1: view

miRNA for ARMT1 Gene

miRTarBase miRNAs that target ARMT1

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARMT1 Gene

Localization for ARMT1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARMT1 gene
Compartment Confidence
cytosol 3
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ARMT1 Gene

Pathways & Interactions for ARMT1 Gene

SuperPathways for ARMT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006479 protein methylation IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0032259 methylation IDA,IEA 25732820
GO:2001020 regulation of response to DNA damage stimulus IMP 25732820
genes like me logo Genes that share ontologies with ARMT1: view

No data available for Pathways by source and SIGNOR curated interactions for ARMT1 Gene

Drugs & Compounds for ARMT1 Gene

No Compound Related Data Available

Transcripts for ARMT1 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARMT1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - - -
SP2: - - - -
SP3: -
SP4: - - -

Relevant External Links for ARMT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARMT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARMT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARMT1 Gene

This gene is overexpressed in Breast (6.7), Oral epithelium (6.3), and Lymph node (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARMT1 Gene

Protein tissue co-expression partners for ARMT1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARMT1 Gene:


Evidence on tissue expression from TISSUES for ARMT1 Gene

  • Liver(4.2)
  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with ARMT1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARMT1 Gene

Orthologs for ARMT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARMT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C6H6orf211 33
  • 99.55 (n)
C6orf211 34
  • 99 (a)
(Canis familiaris)
Mammalia C1H6orf211 33
  • 88.13 (n)
C6ORF211 34
  • 88 (a)
(Bos Taurus)
Mammalia C9H6orf211 33 34
  • 86.39 (n)
(Rattus norvegicus)
Mammalia RGD1305235 33
  • 80.33 (n)
(Mus musculus)
Mammalia 1700052N19Rik 33 34
  • 79.35 (n)
Armt1 16
(Ornithorhynchus anatinus)
Mammalia C6orf211 34
  • 69 (a)
(Monodelphis domestica)
Mammalia C6orf211 34
  • 65 (a)
(Gallus gallus)
Aves C6ORF211 33
  • 72.25 (n)
C6orf211 34
  • 68 (a)
(Anolis carolinensis)
Reptilia C6orf211 34
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c6orf211 33
  • 65.58 (n)
(Danio rerio)
Actinopterygii zgc:110816 33
  • 61.07 (n)
C20H6orf211 34
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010723 33
  • 47.08 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11474 33 34
  • 45.77 (n)
CG2921 34
  • 31 (a)
CG4161 34
  • 29 (a)
CG11475 34
  • 28 (a)
(Caenorhabditis elegans)
Secernentea F31D4.2 33 34
  • 50.83 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YMR027W 33
  • 46.78 (n)
-- 34
  • 28 (a)
-- 36
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C12859g 33
  • 46.7 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC1393.13 33
  • 46.21 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07814 33
  • 43.22 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
Species where no ortholog for ARMT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARMT1 Gene

Gene Tree for ARMT1 (if available)
Gene Tree for ARMT1 (if available)

Paralogs for ARMT1 Gene

No data available for Paralogs for ARMT1 Gene

Variants for ARMT1 Gene

Sequence variations from dbSNP and Humsavar for ARMT1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs3736175 Benign 151,452,029(+) CGGAA(A/G)AGAAG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000014192 -- 151,461,229(+) GAGTT(C/T)GTGTG intron-variant
rs1000066432 -- 151,461,587(+) AATCA(C/T)TTGAA intron-variant
rs1000180898 -- 151,458,153(+) TATGA(A/G)ATCTG intron-variant
rs1000286355 -- 151,452,337(+) TCCGC(G/T)GGCCC upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ARMT1 Gene

Variant ID Type Subtype PubMed ID
nsv1016522 CNV gain 25217958
esv3576236 CNV gain 25503493

Variation tolerance for ARMT1 Gene

Residual Variation Intolerance Score: 47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.56; 64.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARMT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARMT1 Gene

Disorders for ARMT1 Gene

Relevant External Links for ARMT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARMT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARMT1 Gene

Publications for ARMT1 Gene

  1. Human C6orf211 encodes Armt1, a protein carboxyl methyltransferase that targets PCNA and is linked to the DNA damage response. (PMID: 25732820) Perry JJ … Hoelz DJ (Cell reports 2015) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for ARMT1 Gene

Sources for ARMT1 Gene

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