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Aliases for ARMT1 Gene

Aliases for ARMT1 Gene

  • Acidic Residue Methyltransferase 1 2 3 4
  • C6orf211 3 4
  • Chromosome 6 Open Reading Frame 211 2
  • UPF0364 Protein C6orf211 3
  • EC 2.1.1.- 4

External Ids for ARMT1 Gene

Previous HGNC Symbols for ARMT1 Gene

  • C6orf211

Summaries for ARMT1 Gene

GeneCards Summary for ARMT1 Gene

ARMT1 (Acidic Residue Methyltransferase 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ARMT1 Gene

  • O-methyltransferase that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Methylates PCNA, suggesting it is involved in the DNA damage response.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARMT1 Gene

Genomics for ARMT1 Gene

Genomic Location for ARMT1 Gene

151,452,258 bp from pter
151,470,101 bp from pter
17,844 bases
Plus strand

Genomic View for ARMT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARMT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARMT1 Gene

No data available for Regulatory Elements for ARMT1 Gene

Proteins for ARMT1 Gene

  • Protein details for ARMT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein-glutamate O-methyltransferase
    Protein Accession:
    Secondary Accessions:
    • Q96FC6
    • Q9UFY5

    Protein attributes for ARMT1 Gene

    441 amino acids
    Molecular mass:
    51172 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARMT1 Gene

Proteomics data for ARMT1 Gene at MOPED

Post-translational modifications for ARMT1 Gene

Other Protein References for ARMT1 Gene

No data available for DME Specific Peptides for ARMT1 Gene

Domains for ARMT1 Gene

Protein Domains for ARMT1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q9H993
  • Belongs to the ARMT1 family.
genes like me logo Genes that share domains with ARMT1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for ARMT1 Gene

Function for ARMT1 Gene

Molecular function for ARMT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate methyl ester.
UniProtKB/Swiss-Prot Function: O-methyltransferase that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Methylates PCNA, suggesting it is involved in the DNA damage response.

Enzyme Numbers (IUBMB) for ARMT1 Gene

Gene Ontology (GO) - Molecular Function for ARMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25732820
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity IDA 25732820
GO:0019899 enzyme binding IPI 25732820
GO:0051998 protein carboxyl O-methyltransferase activity IDA 25732820
genes like me logo Genes that share ontologies with ARMT1: view

Phenotypes for ARMT1 Gene

GenomeRNAi human phenotypes for ARMT1:
genes like me logo Genes that share phenotypes with ARMT1: view

miRNA for ARMT1 Gene

miRTarBase miRNAs that target ARMT1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ARMT1 Gene

Localization for ARMT1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ARMT1 Gene

Pathways for ARMT1 Gene

SuperPathways for ARMT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006479 protein methylation IDA 25732820
GO:0032259 methylation IDA 25732820
GO:2001020 regulation of response to DNA damage stimulus IMP 25732820
genes like me logo Genes that share ontologies with ARMT1: view

No data available for Pathways by source for ARMT1 Gene

Transcripts for ARMT1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ARMT1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - - -
SP2: - - - -
SP3: -
SP4: - - -

Relevant External Links for ARMT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARMT1 Gene

mRNA expression in normal human tissues for ARMT1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ARMT1 Gene

genes like me logo Genes that share expressions with ARMT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARMT1 Gene

Orthologs for ARMT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARMT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C6H6orf211 35
  • 99.55 (n)
  • 99.09 (a)
C6orf211 36
  • 99 (a)
(Bos Taurus)
Mammalia C9H6orf211 35
  • 86.39 (n)
  • 82.99 (a)
C9H6orf211 36
  • 83 (a)
(Canis familiaris)
Mammalia C1H6orf211 35
  • 88.13 (n)
  • 87.98 (a)
C6ORF211 36
  • 88 (a)
(Mus musculus)
Mammalia 1700052N19Rik 35
  • 79.35 (n)
  • 77.45 (a)
1700052N19Rik 16
1700052N19Rik 36
  • 77 (a)
(Monodelphis domestica)
Mammalia C6orf211 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia C6orf211 36
  • 69 (a)
(Rattus norvegicus)
Mammalia RGD1305235 35
  • 80.33 (n)
  • 78.59 (a)
(Gallus gallus)
Aves C6ORF211 35
  • 72.25 (n)
  • 68.4 (a)
C6orf211 36
  • 68 (a)
(Anolis carolinensis)
Reptilia C6orf211 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c6orf211 35
  • 65.58 (n)
  • 64.04 (a)
(Danio rerio)
Actinopterygii C20H6orf211 36
  • 56 (a)
zgc:110816 35
  • 61.07 (n)
  • 57.47 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010723 35
  • 47.08 (n)
  • 38.77 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11474 35
  • 45.77 (n)
  • 35.57 (a)
CG11474 36
  • 33 (a)
CG11475 36
  • 28 (a)
CG2921 36
  • 31 (a)
CG4161 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea F31D4.2 35
  • 50.83 (n)
  • 39.19 (a)
F31D4.2 36
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 28 (a)
-- 38
YMR027W 35
  • 46.78 (n)
  • 35.02 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C12859g 35
  • 46.7 (n)
  • 35.51 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07814 35
  • 43.22 (n)
  • 36.36 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC1393.13 35
  • 46.21 (n)
  • 35.21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for ARMT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARMT1 Gene

Gene Tree for ARMT1 (if available)
Gene Tree for ARMT1 (if available)

Paralogs for ARMT1 Gene

No data available for Paralogs for ARMT1 Gene

Variants for ARMT1 Gene

Sequence variations from dbSNP and Humsavar for ARMT1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs963193 -- 151,468,220(-) ACATG(A/C)CCATC intron-variant
rs1482065 -- 151,459,257(-) ATCCT(G/T)ATTTA intron-variant
rs3734801 -- 151,468,147(+) ATTTC(A/C)GTTTT intron-variant
rs3886419 -- 151,467,041(-) actcc(G/T)ggcct intron-variant
rs4035344 -- 151,462,942(+) GGGCC(A/G)TGTGG intron-variant

Relevant External Links for ARMT1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARMT1 Gene

Disorders for ARMT1 Gene

No disorders were found for ARMT1 Gene.

No data available for UniProtKB/Swiss-Prot for ARMT1 Gene

Publications for ARMT1 Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Human C6orf211 encodes Armt1, a protein carboxyl methyltransferase that targets PCNA and is linked to the DNA damage response. (PMID: 25732820) Perry J.J. … Hoelz D.J. (Cell Rep 2015) 3 4
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4

Products for ARMT1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ARMT1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ARMT1
    • Block miRNA regulation of ARMT1 using miScript Target Protectors

    Sources for ARMT1 Gene

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