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Aliases for ARMCX6 Gene

Aliases for ARMCX6 Gene

  • Armadillo Repeat Containing, X-Linked 6 2 3 5
  • Protein ARMCX6 3
  • GASP10 3

External Ids for ARMCX6 Gene

Previous GeneCards Identifiers for ARMCX6 Gene

  • GC0XM100676
  • GC0XM100756
  • GC0XM100870
  • GC0XM090660

Summaries for ARMCX6 Gene

GeneCards Summary for ARMCX6 Gene

ARMCX6 (Armadillo Repeat Containing, X-Linked 6) is a Protein Coding gene. An important paralog of this gene is ARMCX3.

Gene Wiki entry for ARMCX6 Gene

Additional gene information for ARMCX6 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARMCX6 Gene

Genomics for ARMCX6 Gene

Regulatory Elements for ARMCX6 Gene

Enhancers for ARMCX6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH101799 0.9 Ensembl ENCODE 12.4 -181.5 -181528 0.3 CTCF MAZ ZNF654 PKNOX1 TRIM22 ELF1 ZBTB40 RAD21 ZNF518A SMC3 ARMCX2 ARMCX6 ARMCX3 ARMCX3-AS1 GK4P NXF5
GH0XH101622 0.9 ENCODE 6.1 -5.4 -5350 2.6 ATF1 ZNF133 SIN3A ZNF366 ATF7 CREM IKZF2 EGR2 SP3 SMAD5 BEX5 ARMCX6 ARMCX3 ARMCX3-AS1
GH0XH101616 0.8 ENCODE 4.5 +0.3 326 1.8 GTF2F1 CTCF MXI1 ATF1 MAX DMAP1 RAD21 YY1 E2F1 ZFHX2 ARL13A ARMCX3 ARMCX6 GC0XM101605
GH0XH101619 1.1 FANTOM5 Ensembl ENCODE 0.7 -1.4 -1439 0.7 SIX4 PKNOX1 MAZ GLIS2 JUN ATF7 ARMCX3 BTK ARMCX6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARMCX6 on UCSC Golden Path with GeneCards custom track

Promoters for ARMCX6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247641 401 1600 GTF2F1 CTCF MXI1 ATF1 MAX DMAP1 RAD21 YY1 E2F1 POLR2A

Genomic Locations for ARMCX6 Gene

Genomic Locations for ARMCX6 Gene
chrX:101,615,118-101,618,001
(GRCh38/hg38)
Size:
2,884 bases
Orientation:
Minus strand
chrX:100,870,108-100,872,991
(GRCh37/hg19)

Genomic View for ARMCX6 Gene

Genes around ARMCX6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARMCX6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARMCX6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARMCX6 Gene

Proteins for ARMCX6 Gene

  • Protein details for ARMCX6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L4S7-ARMX6_HUMAN
    Recommended name:
    Protein ARMCX6
    Protein Accession:
    Q7L4S7
    Secondary Accessions:
    • Q9NWJ3

    Protein attributes for ARMCX6 Gene

    Size:
    300 amino acids
    Molecular mass:
    33019 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91387.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ARMCX6 Gene

Post-translational modifications for ARMCX6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARMCX6 Gene

No data available for DME Specific Peptides for ARMCX6 Gene

Domains & Families for ARMCX6 Gene

Gene Families for ARMCX6 Gene

Protein Domains for ARMCX6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ARMCX6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARMCX6: view

No data available for UniProtKB/Swiss-Prot for ARMCX6 Gene

Function for ARMCX6 Gene

genes like me logo Genes that share phenotypes with ARMCX6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARMCX6 Gene

Localization for ARMCX6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARMCX6 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARMCX6 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2
extracellular 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nuclear membrane (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARMCX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ARMCX6: view

Pathways & Interactions for ARMCX6 Gene

SuperPathways for ARMCX6 Gene

No Data Available

Interacting Proteins for ARMCX6 Gene

Gene Ontology (GO) - Biological Process for ARMCX6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ARMCX6 Gene

Drugs & Compounds for ARMCX6 Gene

No Compound Related Data Available

Transcripts for ARMCX6 Gene

Unigene Clusters for ARMCX6 Gene

Armadillo repeat containing, X-linked 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARMCX6 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f · 4g ^ 5a · 5b · 5c · 5d · 5e
SP1: - - - - - - -
SP2: -
SP3: - -
SP4: - - - - -
SP5: - - - -
SP6: - - - - - - - - -
SP7: - - -
SP8: - - - - -
SP9: - -

Relevant External Links for ARMCX6 Gene

GeneLoc Exon Structure for
ARMCX6
ECgene alternative splicing isoforms for
ARMCX6

Expression for ARMCX6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARMCX6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARMCX6 Gene

This gene is overexpressed in Urine (32.4) and Frontal cortex (26.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARMCX6 Gene



Protein tissue co-expression partners for ARMCX6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARMCX6 Gene:

ARMCX6

SOURCE GeneReport for Unigene cluster for ARMCX6 Gene:

Hs.83530

Evidence on tissue expression from TISSUES for ARMCX6 Gene

  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with ARMCX6: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARMCX6 Gene

Orthologs for ARMCX6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ARMCX6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARMCX6 33 34
  • 98.12 (n)
dog
(Canis familiaris)
Mammalia ARMCX6 33 34
  • 87.58 (n)
cow
(Bos Taurus)
Mammalia ARMCX6 33 34
  • 84.68 (n)
mouse
(Mus musculus)
Mammalia Armcx6 33 16 34
  • 78.67 (n)
rat
(Rattus norvegicus)
Mammalia Armcx6 33
  • 78.44 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 27 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 24 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 24 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ARMCX3 34
  • 17 (a)
OneToMany
Species where no ortholog for ARMCX6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARMCX6 Gene

ENSEMBL:
Gene Tree for ARMCX6 (if available)
TreeFam:
Gene Tree for ARMCX6 (if available)

Paralogs for ARMCX6 Gene

Paralogs for ARMCX6 Gene

(1) SIMAP similar genes for ARMCX6 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ARMCX6 Gene

genes like me logo Genes that share paralogs with ARMCX6: view

Variants for ARMCX6 Gene

Sequence variations from dbSNP and Humsavar for ARMCX6 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000095926 -- 101,616,613(+) GAGCC(C/T)GGCCC intron-variant, reference, missense
rs1000161830 -- 101,618,087(+) TCCCC(C/T)TCAAC upstream-variant-2KB
rs1000592055 -- 101,616,282(+) GCACT(C/G)CAAGT intron-variant, reference, missense
rs1004275555 -- 101,616,981(+) AGCTA(A/G)GAGGG intron-variant
rs1004656963 -- 101,617,281(+) CTCAT(A/G)CTCTA intron-variant, splice-donor-variant

Structural Variations from Database of Genomic Variants (DGV) for ARMCX6 Gene

Variant ID Type Subtype PubMed ID
nsv207 OTHER inversion 15895083
nsv499128 OTHER inversion 21111241
nsv522728 CNV gain 19592680
nsv524711 CNV gain 19592680
nsv7452 OTHER inversion 18451855

Variation tolerance for ARMCX6 Gene

Residual Variation Intolerance Score: 46.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.47; 64.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARMCX6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARMCX6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARMCX6 Gene

Disorders for ARMCX6 Gene

Relevant External Links for ARMCX6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARMCX6

No disorders were found for ARMCX6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARMCX6 Gene

Publications for ARMCX6 Gene

  1. The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2. (PMID: 22569362) López-Doménech G … Soriano E (Nature communications 2012) 2 3 60
  2. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter EE … Ponting CP (BMC evolutionary biology 2005) 2 3 60
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for ARMCX6 Gene

Sources for ARMCX6 Gene

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