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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARMCX6 Gene

protein-coding   GIFtS: 45
GCID: GC0XM100870

Armadillo Repeat Containing, X-Linked 6

  Search for ARMCX6
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Armadillo Repeat Containing, X-Linked 61 2
Protein ARMCX62

External Ids:    HGNC: 260941   Entrez Gene: 544702   Ensembl: ENSG000001989607   UniProtKB: Q7L4S73   
ORGUL members:         
NONCODE14:n409315 n409316      

Export aliases for ARMCX6 gene to outside databases

Previous GC identifers: GC0XM100676 GC0XM100756 GC0XM090660


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ARMCX6 Gene: 
ARMCX6 (armadillo repeat containing, X-linked 6) is a protein-coding gene, and is affiliated with the lncRNA class. An important paralog of this gene is GPRASP2.

Gene Wiki entry for ARMCX6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_011651.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARMCX6 gene promoter:
         Spz1   IRF-1   FOXL1   GATA-1   Gfi-1   C/EBPalpha   N-Myc   HOXA5   FOXO4   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARMCX6 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARMCX6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARMCX6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq21.33-q22.3   Ensembl cytogenetic band:  Xq22.1   HGNC cytogenetic band: Xq21.33-q22.3

ARMCX6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARMCX6 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM100870:  view genomic region     (about GC identifiers)

Start:
100,870,108 bp from pter      End:
100,872,991 bp from pter
Size:
2,884 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARMX6_HUMAN, Q7L4S7 (See protein sequence)
Recommended Name: Protein ARMCX6  
Size: 300 amino acids; 33019 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=BAA91387.1; Type=Erroneous initiation;
Secondary accessions: Q9NWJ3

Explore the universe of human proteins at neXtProt for ARMCX6: NX_Q7L4S7

Explore proteomics data for ARMCX6 at MOPED 

ARMCX6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

ARMCX6 Protein Expression

REFSEQ proteins (3 alternative transcripts): 
NP_001009584.1  NP_001171697.1  NP_061880.2  

ENSEMBL proteins: 
 ENSP00000354708   ENSP00000444537   ENSP00000440648  

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--

ARMCX6 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
ARMC: Armadillo repeat containing

1 InterPro protein domain:
 IPR006911 ARM-rpt_dom

Graphical View of Domain Structure for InterPro Entry Q7L4S7

ProtoNet protein and cluster: Q7L4S7


ARMCX6 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
     1 GenomeRNAi human phenotype for ARMCX6:
 Increased HPV18 LCR reporter a 

Animal Models:
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SwitchGear 3'UTR luciferase reporter plasmidARMCX6 3' UTR sequence
Inhib. RNA
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section




Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARMCX6

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ARMCX6 (ARMX6)

Search CenterWatch for drugs/clinical trials and news about ARMCX6 / ARMX6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ARMCX6 gene (3 alternative transcripts): 
NM_001009584.1  NM_001184768.1  NM_019007.3  

Unigene Cluster for ARMCX6:

Armadillo repeat containing, X-linked 6
Hs.83530  [show with all ESTs]
Unigene Representative Sequence: AK097018
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000497931 ENST00000361910(uc022cam.1 uc004ehx.3 uc004ehy.3)
ENST00000462302 ENST00000467089 ENST00000495964 ENST00000494624 ENST00000539247(uc022cal.1 uc022can.1)
ENST00000538627
miRNA
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hsa-miR-140-3p hsa-miR-330-3p hsa-miR-3682-3p hsa-miR-548s hsa-miR-3941
SwitchGear 3'UTR luciferase reporter plasmidARMCX6 3' UTR sequence
Inhib. RNA
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                     Customized lentivirus expression plasmids for stable overexpression of ARMCX6 
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Additional mRNA sequence: 

AK000818.1 AK097018.1 BC007677.2 L20773.1 NR_033669.1 NR_033670.1 

13 DOTS entries:

DT.100790239  DT.100790242  DT.95246160  DT.91778181  DT.95292616  DT.100676201  DT.95292629  DT.91778173 
DT.95292602  DT.100790237  DT.100790238  DT.95182675  DT.121309545 

24/249 AceView cDNA sequences (see all 249):

BM129575 BM423848 NM_019007 CR624030 BI753457 AA278520 CA418753 BI756446 
AA031351 CR591698 BE745597 BM129309 BM726818 CN480798 AI589343 AI570656 
AA583833 AI079916 AI198773 BE675984 AV718299 AI368779 CR614615 W73865 

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ARMCX6 (see all 9)    About this scheme

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f · 4g ^ 5a · 5b · 5c · 5d · 5e
SP1:              -                 -     -                       -     -     -     -                                 
SP2:              -                                                                                                   
SP3:              -                       -                                                                           
SP4:              -                 -     -                                   -     -                                 
SP5:                                                              -     -     -     -                                 


ECgene alternative splicing isoforms for ARMCX6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ARMCX6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGGTGAGGGG
ARMCX6 Expression
About this image


See ARMCX6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARMCX6

SOURCE GeneReport for Unigene cluster: Hs.83530
    SABiosciences Custom PCR Arrays for ARMCX6
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARMCX6

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ARMCX6 gene from 4/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Armcx61 , 5 armadillo repeat containing, X-linked 61, 5 78.67(n)1
70(a)1
  X (56.25 cM)5
2780971  NM_001007578.21  NP_001007579.11 
 1347484615 
chicken
(Gallus gallus)
Aves --
--
23(a)
1 → many
1(12726364-12735694)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
24(a)
1 → many
5(95300984-95312074)
zebrafish
(Danio rerio)
Actinopterygii ARMC106
armadillo repeat containing 10
17(a)
1 → many
25(19368324-19378456)


ENSEMBL Gene Tree for ARMCX6 (if available)
TreeFam Gene Tree for ARMCX6 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for ARMCX6 gene
GPRASP22  ARMCX12  BHLHB92  ARMCX22  GPRASP12  ARMCX52  ARMC102  ARMCX32  
1 SIMAP similar gene for ARMCX6 using alignment to 1 protein entry:     ARMX6_HUMAN:
ARMCX3

ARMCX6 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for ARMCX6
PGOHUM00000241910


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/77 SNPs in ARMCX6 are shown (see all 77)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2014960811,2
--100870904(+) CTGAAA/GCGGAC 16 A V mis1 int10--------
rs2007590861,2
C--100870913(+) ACTTGA/GCAAGC 16 A V mis1 int10--------
rs353191861,2
C,F--100871148(+) ATGGCT/CATTGA 16 /S /G mis1 int11Minor allele frequency- C:0.10NA 3026
rs1497628671,2
C,F--100871156(+) TGATAT/CCCTGG 16 /D /G mis1 int11Minor allele frequency- C:0.00NA 3224
rs2000765521,2
--100871191(+) GGCTCA/GGCAAA 16 A syn1 int10--------
rs617438311,2
C,F--100871236(+) AGGTCC/TAGAAC 16 L syn1 int12Minor allele frequency- T:0.00NS NA 4624
rs2013098191,2
C--100871264(+) AATTTC/TGAGCA 16 Q R mis1 int10--------
rs2004271791,2
C--100871273(+) CACTCC/GAAGTA 16 S W mis1 int10--------
rs1996394471,2
--100871284(+) TTTTTA/GTGTTC 16 H syn1 int10--------
rs115393071,2
H--100871315(-) ACACCC/AAATAA 16 /Q /P mis1 int1 ese34Minor allele frequency- A:0.00NS EA 402

HapMap Linkage Disequilibrium report for ARMCX6 (100870108 - 100872991 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for ARMCX6:    About this table     
Variant IDTypeSubtypePubMed ID
nsv522728CNV Gain19592680
nsv524711CNV Gain19592680
nsv499128OTHER Inversion21111241
nsv207OTHER Inversion15895083
nsv7452OTHER Inversion18451855


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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for ARMCX6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ARMCX6)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
  6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (2006)
  7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 54470 HGNC: 26094 AceView: ARMCX6 Ensembl:ENSG00000198960 euGenes: HUgn54470
ECgene: ARMCX6 H-InvDB: ARMCX6

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for ARMCX6 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for ARMCX6 gene:
Search GeneIP for patents involving ARMCX6

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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