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ARMCX5 Gene

protein-coding   GIFtS: 43
GCID: GC0XP101854

Armadillo Repeat Containing, X-Linked 5

  Search for ARMCX5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Armadillo Repeat Containing, X-Linked 51 2
GASP52
Armadillo Repeat-Containing X-Linked Protein 52

External Ids:    HGNC: 257721   Entrez Gene: 648602   Ensembl: ENSG000001259627   UniProtKB: Q6P1M93   

Export aliases for ARMCX5 gene to outside databases

Previous GC identifers: GC0XP101660 GC0XP091519


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ARMCX5 Gene:
ARMCX5 (armadillo repeat containing, X-linked 5) is a protein-coding gene. An important paralog of this gene is GPRASP2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011651.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARMCX5 gene promoter:
         Bach1   GR   TBP   Pax-6   SRY   TFIID   FOXJ2 (long isoform)   GR-alpha   FOXJ2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARMCX5 promoter sequence
   Search Chromatin IP Primers for ARMCX5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARMCX5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.1-q22.3   Ensembl cytogenetic band:  Xq22.1   HGNC cytogenetic band: Xq22.1-q22.3

ARMCX5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARMCX5 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP101854:  view genomic region     (about GC identifiers)

Start:
101,854,096 bp from pter      End:
101,859,087 bp from pter
Size:
4,992 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARMX5_HUMAN, Q6P1M9 (See protein sequence)
Recommended Name: Armadillo repeat-containing X-linked protein 5  
Size: 558 amino acids; 62346 Da
Secondary accessions: B3KU88 D3DX99 Q68DB4 Q9BVZ3 Q9H969

Explore the universe of human proteins at neXtProt for ARMCX5: NX_Q6P1M9

Explore proteomics data for ARMCX5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARMCX5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001161950.1  NP_001161951.1  NP_001161952.1  NP_001161954.1  NP_001161957.1  NP_073749.2  

    ENSEMBL proteins: 
     ENSP00000246174   ENSP00000473737   ENSP00000474720   ENSP00000474484   ENSP00000474470  
     ENSP00000361827   ENSP00000439001   ENSP00000446385   ENSP00000445851  

    ARMCX5 Human Recombinant Protein Products:

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    Cloud-Clone Corp. ELISAs for ARMCX5
    Cloud-Clone Corp. CLIAs for ARMCX5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARMC: Armadillo repeat containing

    3 InterPro protein domains:
     IPR011989 ARM-like
     IPR006911 ARM-rpt_dom
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q6P1M9

    ProtoNet protein and cluster: Q6P1M9

    UniProtKB/Swiss-Prot: ARMX5_HUMAN, Q6P1M9
    Similarity: Contains 3 ARM repeats


    ARMCX5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
         
    ARMCX5 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARMCX5
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARMCX5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARMCX5

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate ARMCX5:
    hsa-miR-3163 hsa-miR-4328 hsa-miR-891b
    SwitchGear 3'UTR luciferase reporter plasmidARMCX5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ARMCX5
    Predesigned siRNA for gene silencing in human, mouse, rat ARMCX5

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for ARMCX5

    Clone
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    OriGene clones in human, mouse for ARMCX5 (see all 27)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): ARMCX5 (NM_022838)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARMCX5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARMCX5

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARMCX5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARMCX5
    Interactions:

        Search GeneGlobe Interaction Network for ARMCX5

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ARMCX5 (ENSP000002461744) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARMCX5 (ARMX5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARMCX5 gene (6 alternative transcripts): 
    NM_001168478.1  NM_001168479.1  NM_001168480.1  NM_001168482.1  NM_001168485.1  NM_022838.3  

    Unigene Cluster for ARMCX5:

    Armadillo repeat containing, X-linked 5
    Hs.522729  [show with all ESTs]
    Unigene Representative Sequence: NM_001199818
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000246174(uc004ejg.3 uc022cax.1) ENST00000473968 ENST00000604957
    ENST00000477663 ENST00000479502 ENST00000372742 ENST00000537008(uc022caw.1)
    ENST00000541409 ENST00000536530(uc022caz.1 uc022cba.1 uc004ejh.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ARMCX5 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate ARMCX5:
    hsa-miR-3163 hsa-miR-4328 hsa-miR-891b
    SwitchGear 3'UTR luciferase reporter plasmidARMCX5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ARMCX5
    Predesigned siRNA for gene silencing in human, mouse, rat ARMCX5
    Clone
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    OriGene clones in human, mouse for ARMCX5 (see all 27)
    OriGene ORF clones in mouse, rat for ARMCX5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): ARMCX5 (NM_022838)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARMCX5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARMCX5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ARMCX5
    OriGene qSTAR qPCR primer pairs in human, mouse for ARMCX5
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ARMCX5
      QuantiTect SYBR Green Assays in human, mouse, rat ARMCX5
      QuantiFast Probe-based Assays in human, mouse, rat ARMCX5

    Additional mRNA sequence: 

    AK023031.1 AK092981.1 AK094646.1 AK096067.1 AK096692.1 AL832187.1 BC000792.1 BC013576.1 
    BC022066.2 BC047679.1 BC050678.1 BC058904.1 BC064983.1 

    23 DOTS entries:

    DT.99941501  DT.121305738  DT.91754972  DT.441264  DT.100027519  DT.100821796  DT.95263615  DT.95375602 
    DT.121305830  DT.121305856  DT.212424  DT.100784510  DT.121305832  DT.442728  DT.91963431  DT.97845890 
    DT.433306  DT.121305622  DT.95375599  DT.100784512  DT.121305708  DT.75152121  DT.97773899 

    Selected AceView cDNA sequences (see all 206):

    AK096692 AA992143 CD676934 AA336707 AA282402 AA622241 AA725145 NM_022838 
    AV727869 BQ949516 AI815557 CA950531 Z44856 T03673 AW293629 AK023031 
    BQ012171 AW014017 BQ954981 BC050678 CR596060 AL134721 BC064983 BF437080 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARMCX5 (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h · 6i ^ 7a ·
    SP1:                                            -                       -           -           -                                                               
    SP2:                                            -                       -           -           -                                                               
    SP3:                                            -                       -     -     -           -                 -     -     -     -     -     -     -         
    SP4:                                                                    -           -           -                 -     -     -     -     -     -     -         
    SP5:                                            -                       -     -     -           -                                                               

    ExUns: 7b · 7c · 7d
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for ARMCX5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARMCX5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAAAACTGG
    ARMCX5 Expression
    About this image

    ARMCX5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARMCX5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522729
        Custom PCR Arrays for ARMCX5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARMCX5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ARMCX5 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Armcx51 , 5 armadillo repeat containing, X-linked 51, 5 76.24(n)1
    61.58(a)1
      X (57.26 cM)5
    4944681  NM_001009575.51  NP_001009575.21 
     1357427335 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    28(a)
    1 → many
    1(12726364-12735694)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    26(a)
    1 → many
    5(95300984-95312074)
    zebrafish
    (Danio rerio)
    Actinopterygii ARMCX36
    armadillo repeat containing, X-linked 3
    21(a)
    1 → many
    25(19368321-19378457) ENSDARG00000062960


    ENSEMBL Gene Tree for ARMCX5 (if available)
    TreeFam Gene Tree for ARMCX5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARMCX5 gene
    GPRASP22  ARMCX12  BHLHB92  ARMCX22  GPRASP12  ARMCX62  ARMC102  ARMCX32  
    3 SIMAP similar genes for ARMCX5 using alignment to 3 protein entries:     ARMX5_HUMAN (see all proteins):
    ARMCX3    BHLHB9    ARMCX4

    ARMCX5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARMCX5 (see all 104)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1505561231,2
    --101821397(+) TCAAGA/GAAATC 3 -- us2k10--------
    rs1848391811,2
    --101821570(+) TTCACA/GCAGAG 6 -- us2k10--------
    rs1903876581,2
    --101821590(+) AGCTCG/TTATAG 6 -- us2k10--------
    rs1817081001,2
    --101821639(+) ATCACA/GCTACC 6 -- us2k10--------
    rs2001760241,2
    --101821681(+) ACCTT-/GTAG  
            
    AACAG
    6 -- us2k10--------
    rs1848876351,2
    --101821737(+) GAATAG/TAGAAC 6 -- us2k10--------
    rs1894424521,2
    --101822046(+) ACAAAG/TGGGAT 6 -- us2k10--------
    rs59457361,2
    C--101822097(+) tcatcA/C/Ggagtg 6 -- us2k11NA 2
    rs1851937971,2
    --101822191(+) ATTTAC/TGAGAA 6 -- us2k10--------
    rs1896642861,2
    --101822345(+) GATACC/TATCTC 6 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARMCX5 (101854096 - 101859087 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ARMCX5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv526716CNV Gain19592680

    Locus Specific Mutation Databases (LSDB): ARMCX5

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARMCX5
    DNA2.0 Custom Variant and Variant Library Synthesis for ARMCX5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARMCX5 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with ARMCX5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2. (PubMed id 22569362)1, 3 LA^pez-DomAcnech G....Soriano E. (Nat Commun 2012)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    3. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PubMed id 16221301)1, 3 Winter E.E. and Ponting C.P. (BMC Evol. Biol. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64860 HGNC: 25772 AceView: GPRASP1andARMCX5 Ensembl:ENSG00000125962 euGenes: HUgn64860
    ECgene: ARMCX5 H-InvDB: ARMCX5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARMCX5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARMCX5 gene:
    Search GeneIP for patents involving ARMCX5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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