ARMCX4 Gene
protein-coding GIFtS: 38
GCID: GC0XP100673
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armadillo repeat containing, X-linked 4(Previous names: chromosome X open reading frame 35, armadillo repeat containing,...)
(Previous symbol: CXorf35)
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Aliases
for ARMCX4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Armadillo Repeat Containing, X-Linked 41 2 | | CXorf351 2 | | Armadillo Repeat Containing, X-Linked 4 Pseudogene1 2 | | MGC400531 | | Chromosome X Open Reading Frame 351 | | Armadillo Repeat-Containing X-Linked Protein 42 |
| External Ids: | HGNC: 286151 | Entrez Gene: 1001317552 | Ensembl: ENSG000001964407 | UniProtKB: Q5H9R43 | | ORGUL members: | |
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| NONCODE:n385793 | |
Export aliases for ARMCX4 gene to outside databasesPrevious GC identifers: GC0XP100546 GC0XP100627 GC0XU901218 GC0XP100561 GC0XP090479
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Summaries
for ARMCX4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ARMCX4:
The product of this gene belongs to the armadillo repeat-containing family of proteins, which interact with otherproteins in a variety of cellular processes. The function of this family member is currently unknown. Alternativesplicing of this gene results in multiple transcript variants. (provided by RefSeq, Jan 2012)
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Genomic Views
for ARMCX4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011651.17
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ARMCX4
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARMCX4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARMCX4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq22.1 Ensembl cytogenetic band: Xq22.1 HGNC cytogenetic band: Xq22ARMCX4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP100673: view genomic region
(about GC identifiers)
Start:
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100,673,266 bp from pter |
End:
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100,788,446 bp from pter |
Size:
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115,181 bases |
Orientation:
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plus strand |
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Proteins
for ARMCX4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ARMX4_HUMAN, Q5H9R4 (See
protein sequence)Recommended Name: Armadillo repeat-containing X-linked protein 4 Size: 360 amino acids; 39406 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: A8K928 B3KXA4 Q5H9K8 Q8N8D6Alternative splicing: 2 isoforms: Q5H9R4-1 Q5H9R4-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ARMCX4: NX_Q5H9R4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5H9R4
ARMCX4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001243084.1
ENSEMBL proteins: ENSP00000424452 ENSP00000422573 ENSP00000425302 ENSP00000423440 ENSP00000426585 ENSP00000423927 ENSP00000404304
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
ARMCX4 for ontologies About GeneDecksing
ARMCX4 Antibody Products:
Assay Products for ARMCX4: |
Protein
Domains /
Families
for ARMCX4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q5H9R4 |
Function
for ARMCX4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARMCX4 |
1 GenomeRNAi human phenotype for ARMCX4:
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Pathways & Interactions
for ARMCX4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARMCX4
|
Drugs & Compounds
for ARMCX4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ARMCX4
Search CenterWatch for drugs/clinical trials and news about ARMCX4 / ARMX4 
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Transcripts
for ARMCX4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for ARMCX4 gene (2 alternative transcripts): NM_152583.2 NM_001256155.1 Unigene Cluster for ARMCX4: Armadillo repeat containing, X-linked 4 Hs.729062 [show with all ESTs]Unigene Representative Sequence: NR_02840710 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000433011(uc004eho.2) ENST00000430461 ENST00000453574 ENST00000431677
ENST00000445416(uc022caj.1) ENST00000452188(uc004ehp.2 uc004ehr.2 uc004ehs.2)
ENST00000455331 ENST00000442270(uc004eht.2) ENST00000354842 ENST00000423738
Additional cDNA sequence: AK096955.1 AK125041.1 AK126987.1 AK292543.1 AL050285.1 AY726601.1 BC032236.1 BC036206.1 CR933662.1 NR_028407.2 NR_045861.1 NR_045862.1 NR_045863.1 NR_045864.1 15 DOTS entries: DT.211474 DT.95361872 DT.100812315 DT.95255657 DT.100653257 DT.91679582 DT.40249069 DT.70104777 DT.91749742 DT.101982813 DT.121297393 DT.75123992 DT.102829343 DT.100648462 DT.121309545
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ARMCX4 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · | 10b |
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| SP1: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | - | | - | | - | | - | | | | | | - | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ARMCX4
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Expression
for ARMCX4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARMCX4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCCAGGACA
About this image
See ARMCX4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARMCX4
SOURCE GeneReport for Unigene cluster: Hs.729062
SABiosciences Custom PCR Arrays for ARMCX4
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ARMCX4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARMCX4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARMCX4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARMCX4 |
Orthologs
for ARMCX4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for ARMCX4 (if available)
TreeFam Gene Tree for ARMCX4 (if available) |
Paralogs
for ARMCX4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ARMCX4 gene
- GPRASP22 ARMCX12 BHLHB92 ARMCX22 GPRASP12 ARMCX52 ARMCX62 ARMC102
- ARMCX32
5 SIMAP similar genes for ARMCX4 using alignment to 4 protein entries: ARMX4_HUMAN (see all proteins):DKFZp686P06199 ARMCX3 ARMC10 ARMCX1 ARMCX5
ARMCX4 for paralogs About GeneDecksing
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Genomic Variants
for ARMCX4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ARMCX4 (100673266 - 100788446 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for ARMCX4
3 CNVs: 96855 96856 83653
3 Indels: 83652 96854 103267
Locus Specific Mutation Databases (LSDB): ARMCX4
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for ARMCX4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ARMCX4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARMCX4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ARMCX4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)1, 2 Bechtel S.... Schupp I. (2007)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
- The armadillo family of structural proteins. (PubMed id 9770300)1 Hatzfeld M. (1999)
- A repeating amino acid motif shared by proteins with diverse cellular roles. (PubMed id 7907279)1 Peifer M....Reynolds A.B. (1994)
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External Searches for ARMCX4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing ARMCX4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing ARMCX4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ARMCX4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ARMCX4 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for ARMCX4 gene:
Search GeneIP for patents involving ARMCX4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ARMCX4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARMCX4 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARMCX4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARMCX4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARMCX4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARMCX4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARMCX4 |
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 |  |  |  | |
| | | | Search Tocris compounds for ARMCX4 |
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 | | | ARMCX4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARMCX4 |
|  |  |  | | | | Search ThermoFisher Antibodies for ARMCX4 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARMCX4 |
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