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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARMCX3 Gene

protein-coding   GIFtS: 49
GCID: GC0XP100878

armadillo repeat containing, X-linked 3

 Explore 2 diseases affiliated with
ARMCX3 via our new
 Human Malady Compendium 
Biological research products
for ARMCX3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Armadillo Repeat Containing, X-Linked 31 2     Arm Protein Lost In Epithelial Cancers, X Chromosome, 32
ALEX31 2 3 5     Armadillo Repeat-Containing X-Linked Protein 32
ARM Protein Lost In Epithelial Cancers On Chromosome X 32 3     DJ545K15.21
1200004E24Rik2     Protein ALEX33

External Ids:    HGNC: 240651   Entrez Gene: 515662   Ensembl: ENSG000001024017   OMIM: 3003645   UniProtKB: Q9UH623   

Export aliases for ARMCX3 gene to outside databases

Previous GC identifers: GC0XP099650 GC0XP100684 GC0XP100764 GC0XP090685


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARMCX3:
This gene encodes a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded
protein contains a potential N-terminal transmembrane domain and a single Armadillo (arm) repeat. Other proteins
containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene
is closely localized with other family members on the X chromosome. Three transcript variants encoding the same
protein have been identified for this gene. (provided by RefSeq, Jul 2008)

Gene Wiki entry for ARMCX3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011651.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARMCX3 gene promoter:
         N-Myc   FOXO4   HOXA5   IRF-1   Gfi-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARMCX3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARMCX3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARMCX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.1   Ensembl cytogenetic band:  Xq22.1   HGNC cytogenetic band: Xq22.1

ARMCX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARMCX3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP100878:  view genomic region     (about GC identifiers)

Start:
100,877,787 bp from pter      End:
100,882,833 bp from pter
Size:
5,047 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ARMX3_HUMAN, Q9UH62 (See protein sequence)
Recommended Name: Armadillo repeat-containing X-linked protein 3  
Size: 379 amino acids; 42501 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: Q53HC6 Q7LCF5 Q9NPE4

Explore the universe of human proteins at neXtProt for ARMCX3: NX_Q9UH62

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UH62

  • ARMCX3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_057691.1  NP_808816.1  NP_808817.1  

    ENSEMBL proteins: 
     ENSP00000340672   ENSP00000454483   ENSP00000457997   ENSP00000454251   ENSP00000439032  

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    Uscn Proteins for ARMCX3

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031307integral to mitochondrial outer membrane IEA--


    ARMCX3 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ARMCX3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR006911 ARM-rpt_dom
     IPR011989 ARM-like
     IPR000225 Armadillo
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9UH62

    ProtoNet protein and cluster: Q9UH62

    UniProtKB/Swiss-Prot: ARMX3_HUMAN, Q9UH62
    Similarity: Contains 3 ARM repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----


    ARMCX3 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARMCX3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/6 Interacting proteins for ARMCX3 (Q9UH622, 3 ENSP000003406724) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLTCQ006102, 3MINT-65733 I2D: score=5 
    IMMTQ168912, 3MINT-65734 I2D: score=5 
    GPN1Q9HCN43, ENSP000002647184I2D: score=1 STRING: ENSP00000264718
    RPAP2Q8IXW53, ENSP000003593684I2D: score=1 STRING: ENSP00000359368
    MAF1Q9H0633, ENSP000003186044I2D: score=2 STRING: ENSP00000318604
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0034613cellular protein localization IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--


    ARMCX3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARMCX3
    Search CenterWatch for drugs/clinical trials and news about ARMCX3 / ARMX3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARMCX3 gene (3 alternative transcripts): 
    NM_016607.3  NM_177947.2  NM_177948.2  

    Unigene Cluster for ARMCX3:

    Armadillo repeat containing, X-linked 3
    Hs.592225  [show with all ESTs]
    Unigene Representative Sequence: CR933656
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341189(uc004ehz.1 uc004eia.1 uc004eib.1) ENST00000471229
    ENST00000491568 ENST00000479298 ENST00000477980 ENST00000467808 ENST00000537169(uc004eic.1)


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    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate ARMCX3 (see all 31):
    hsa-miR-548j hsa-miR-3128 hsa-miR-548i hsa-miR-488 hsa-miR-624 hsa-miR-27b* hsa-miR-548a-5p hsa-miR-548d-5p
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    Additional cDNA sequence: 

    AB039669.1 AF211175.1 AK222655.1 AK291225.1 AY359079.1 BC005194.1 BX647802.1 CR933656.1 
    XR_158967.1 XR_159547.1 XR_172407.1 

    15 DOTS entries:

    DT.91752916  DT.101983942  DT.100010857  DT.100824241  DT.100824238  DT.121307595  DT.100824240  DT.91897020 
    DT.100708259  DT.121307559  DT.95267174  DT.121307561  DT.75169236  DT.91752923  DT.95251256 

    24/286 AceView cDNA sequences (see all 286):

    NM_177948 AW438622 CA425071 AL541156 CR626124 BM723876 BP364667 AY359079 
    BG413377 T31517 AA905223 BC005194 AI419816 AI417989 CF265017 AL540615 
    BX642632 BE350974 AI417034 AL043064 CR616317 BM907377 AA195089 NM_177947 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ARMCX3 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g
    SP1:                          -     -                 -     -                                                                     
    SP2:                          -                       -     -                                                                     
    SP3:                                -                 -     -                                                                     
    SP4:                                                  -     -                                                                     
    SP5:                          -     -     -           -     -                                                                     


    ECgene alternative splicing isoforms for ARMCX3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARMCX3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    ARMCX3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ARMCX3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARMCX3

    SOURCE GeneReport for Unigene cluster: Hs.592225
        SABiosciences Custom PCR Arrays for ARMCX3
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ARMCX3 gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ARMC106
    Uncharacterized protein
    39(a)
    1 → many
    1(13884450-13891606)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    46(a)
    1 → many
    5(95306234-95312068)
    zebrafish
    (Danio rerio)
    Actinopterygii CR391963.36
    --
    27(a)
    1 → many
    25(19368324-19378456)


    ENSEMBL Gene Tree for ARMCX3 (if available)
    TreeFam Gene Tree for ARMCX3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARMCX3 gene
    ARMCX42  GPRASP22  ARMCX12  BHLHB92  ARMCX22  GPRASP12  ARMCX52  ARMCX62  
    ARMC102  
    7 SIMAP similar genes for ARMCX3 using alignment to 3 protein entries:     ARMX3_HUMAN (see all proteins):
    DKFZp686P06199    ARMCX4    ARMCX2    ARMC10    ARMCX6    ARMCX1
    ARMCX5

    ARMCX3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/77 NCBI SNPs in ARMCX3 are shown (see all 77    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22312081,2
    C,--90685235(+) GCTCTC/TCTATT 1 -- ds50010--------
    rs22312101,2
    C,--90685800(+) ATTATC/GGAAGA 1 -- nc-transcript-variant0--------
    rs558416411,2
    --90686015(+) CGGGCC/GGGCCT 1 -- nc-transcript-variant0--------
    rs128467641,2
    C--90686112(+) CTTGAA/GGGCGT 1 -- nc-transcript-variant0--------
    rs617408281,2
    C,F--90688885(+) CTTGCT/CGAACA 1 -- us2k12Minor allele frequency- C:0.00NS NA 3594
    rs1877506081,2
    --100876288(+) TCCCCA/GTAAGT 2 -- us2k10--------
    rs1931145001,2
    --100876587(+) CCTTAA/GCCAAC 3 -- us2k10--------
    rs1855235101,2
    --100877011(+) TTGGTG/TGCAAG 3 -- us2k10--------
    rs1899970581,2
    --100877054(+) TGAGGA/GGATGT 3 -- us2k10--------
    rs27528901,2
    C,F,O,A,H,--100877238(+) ATTCTT/CTATTT 3 -- us2k118Minor allele frequency- C:0.76NS EA NA WA CSA 1956

    HapMap Linkage Disequilibrium report for ARMCX3 (100877787 - 100882833 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ARMCX3
         2 Inversions: 0662 37339
    Locus Specific Mutation Databases (LSDB): ARMCX3

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARMCX3
    DNA2.0 Custom Variant and Variant Library Synthesis for ARMCX3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ARMCX3 for disorders           About GeneDecksing

    OMIM gene information: 300364    OMIM disorders: --

    2 diseases for ARMCX3:    About MalaCards
    choroiditis    carcinoma


    Export disorders for ARMCX3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARMCX3 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with ARMCX3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas. (PubMed id 11162520)1, 2, 3 Kurochkin I.V....Nomura H. (2001)
    2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
    3. The armadillo repeat-containing protein, ARMCX3, phys ically and functionally interacts with the developmental regulatory factor Sox1 0. (PubMed id 19304657)1, 3 Mou Z....Gardner P.D. (2009)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    8. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51566 HGNC: 24065 AceView: ARMCX3 Ensembl:ENSG00000102401 euGenes: HUgn51566
    ECgene: ARMCX3 H-InvDB: ARMCX3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARMCX3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ARMCX3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARMCX3 gene:
    Search GeneIP for patents involving ARMCX3

    GeneCards and IP:
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