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Aliases for ARMCX2 Gene

Aliases for ARMCX2 Gene

  • Armadillo Repeat Containing, X-Linked 2 2 3
  • ALEX2 3 4 6
  • ARM Protein Lost In Epithelial Cancers On Chromosome X 2 3 4
  • KIAA0512 4 6
  • Armadillo Repeat-Containing X-Linked Protein 2 3
  • Armadillo Repeat Protein ALEX2 3
  • Protein ALEX2 4
  • GASP9 3

External Ids for ARMCX2 Gene

Summaries for ARMCX2 Gene

Entrez Gene Summary for ARMCX2 Gene

  • This gene encodes a protein containing a potential N-terminal transmembrane domain and multiple armadillo (arm) repeats. Proteins containing arm repeats are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is located in a cluster of related genes on chromosome X. There is a pseudogene for this gene on chromosome 7. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2013]

GeneCards Summary for ARMCX2 Gene

ARMCX2 (Armadillo Repeat Containing, X-Linked 2) is a Protein Coding gene. An important paralog of this gene is ARMCX6.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARMCX2 Gene

Genomics for ARMCX2 Gene

Genomic Location for ARMCX2 Gene

Start:
101,655,281 bp from pter
End:
101,659,891 bp from pter
Size:
4,611 bases
Orientation:
Minus strand

Genomic View for ARMCX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARMCX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARMCX2 Gene

Regulatory Elements for ARMCX2 Gene

Proteins for ARMCX2 Gene

  • Protein details for ARMCX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L311-ARMX2_HUMAN
    Recommended name:
    Armadillo repeat-containing X-linked protein 2
    Protein Accession:
    Q7L311
    Secondary Accessions:
    • O60267
    • Q5H9D9

    Protein attributes for ARMCX2 Gene

    Size:
    632 amino acids
    Molecular mass:
    65683 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA25438.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ARMCX2 Gene

Proteomics data for ARMCX2 Gene at MOPED

Post-translational modifications for ARMCX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARMCX2 Gene

Domains for ARMCX2 Gene

Gene Families for ARMCX2 Gene

HGNC:
  • ARMC :Armadillo repeat containing

Protein Domains for ARMCX2 Gene

UniProtKB/Swiss-Prot:

ARMX2_HUMAN
Similarity:
  • Contains 3 ARM repeats.:
    • Q7L311
genes like me logo Genes that share domains with ARMCX2: view

Function for ARMCX2 Gene

Gene Ontology (GO) - Molecular Function for ARMCX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ARMCX2: view

Phenotypes for ARMCX2 Gene

GenomeRNAi human phenotypes for ARMCX2:
genes like me logo Genes that share phenotypes with ARMCX2: view

miRNA for ARMCX2 Gene

miRTarBase miRNAs that target ARMCX2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARMCX2 Gene

Localization for ARMCX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARMCX2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARMCX2 Gene COMPARTMENTS Subcellular localization image for ARMCX2 gene
Compartment Confidence
extracellular 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ARMCX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ARMCX2: view

Pathways for ARMCX2 Gene

SuperPathways for ARMCX2 Gene

No Data Available

Interacting Proteins for ARMCX2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000328631%0d%0a9606.ENSP00000224237%0d%0a
Selected Interacting proteins: Q7L311-ARMX2_HUMAN ENSP00000328631 for ARMCX2 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for ARMCX2 Gene

None

No data available for Pathways by source for ARMCX2 Gene

Transcripts for ARMCX2 Gene

Unigene Clusters for ARMCX2 Gene

Armadillo repeat containing, X-linked 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARMCX2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8a · 8b · 8c · 8d ·
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - -
SP10: - - - - -
SP11: - - - - - - -
SP12: - - - - - - - -
SP13: - - - - - - -
SP14: - - - - - - - -
SP15: - - - - - -
SP16: - - - - - - - - - - - - - - -
SP17: - - - - - - - - - -
SP18: - - - - - - - - - -
SP19: - - - - - -
SP20: - - - - - - - - - -
SP21: - - - - - - - - - - -
SP22: - - - - - -
SP23: - - - - - - - - -
SP24: - - - - - - - - - - - -
SP25: - - - - - - - - - -
SP26: - - - - - -
SP27: -
SP28:
SP29: - - - - - - - - - - - - - -

ExUns: 8e · 8f · 8g · 8h · 8i · 8j · 8k · 8l · 8m · 8n · 8o · 8p · 8q · 8r · 8s
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:

Relevant External Links for ARMCX2 Gene

GeneLoc Exon Structure for
ARMCX2
ECgene alternative splicing isoforms for
ARMCX2

Expression for ARMCX2 Gene

mRNA expression in normal human tissues for ARMCX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ARMCX2 Gene

SOURCE GeneReport for Unigene cluster for ARMCX2 Gene Hs.48924

mRNA Expression by UniProt/SwissProt for ARMCX2 Gene

Q7L311-ARMX2_HUMAN
Tissue specificity: Expressed at high levels ovary, heart, testis, prostate, brain, spleen and colon. Expressed at very low levels in liver and thymus. Not expressed in peripheral blood leukocytes. Not expressed in pancreas and ovarian carcinomas.
genes like me logo Genes that share expressions with ARMCX2: view

Orthologs for ARMCX2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ARMCX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARMCX2 36
  • 99.58 (n)
  • 99.37 (a)
ARMCX2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARMCX2 36
  • 87.43 (n)
  • 86.88 (a)
ARMCX2 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARMCX2 36
  • 86.77 (n)
  • 87.54 (a)
ARMCX2 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Armcx2 36
  • 80.26 (n)
  • 78.75 (a)
Armcx2 16
Armcx2 37
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 42 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Armcx2 36
  • 82.53 (n)
  • 84.36 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 35 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 34 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ARMCX3 37
  • 27 (a)
OneToMany
Species with no ortholog for ARMCX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARMCX2 Gene

ENSEMBL:
Gene Tree for ARMCX2 (if available)
TreeFam:
Gene Tree for ARMCX2 (if available)

Paralogs for ARMCX2 Gene

Paralogs for ARMCX2 Gene

Selected SIMAP similar genes for ARMCX2 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ARMCX2 Gene

genes like me logo Genes that share paralogs with ARMCX2: view

Variants for ARMCX2 Gene

Sequence variations from dbSNP and Humsavar for ARMCX2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2071753 -- 101,658,083(+) ATCAA(A/G)AGCAG utr-variant-5-prime
rs2362161 -- 101,661,345(+) ACCAC(C/T)TGGCC upstream-variant-2KB
rs3177613 -- 101,655,286(-) ACTGA(A/C)AAAAA utr-variant-3-prime
rs3788820 -- 101,661,796(-) TTGAA(C/T)ATTTT upstream-variant-2KB
rs3850315 -- 101,656,080(+) AGGTG(C/T)TGGTA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ARMCX2 Gene

Variant ID Type Subtype PubMed ID
nsv522728 CNV Gain 19592680

Relevant External Links for ARMCX2 Gene

HapMap Linkage Disequilibrium report
ARMCX2
Locus Specific Mutation Databases (LSDB)
ARMCX2

Disorders for ARMCX2 Gene

Relevant External Links for ARMCX2

Genetic Association Database (GAD)
ARMCX2
genes like me logo Genes that share disorders with ARMCX2: view

No data available for UniProtKB/Swiss-Prot for ARMCX2 Gene

Publications for ARMCX2 Gene

  1. ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas. (PMID: 11162520) Kurochkin I.V. … Nomura H. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  5. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter E.E. … Ponting C.P. (BMC Evol. Biol. 2005) 2 3

Products for ARMCX2 Gene

Sources for ARMCX2 Gene

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