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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARMCX2 Gene

protein-coding   GIFtS: 53
GCID: GC0XM100910

armadillo repeat containing, X-linked 2

 Explore 4 diseases affiliated with
ARMCX2 via our new
 Human Malady Compendium 
Biological research products
for ARMCX2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Armadillo Repeat Containing, X-Linked 21 2     Arm Protein Lost In Epithelial Cancers, X Chromosome, 22
ALEX21 2 3 5     Armadillo Repeat Protein ALEX22
KIAA05121 3 5     Armadillo Repeat-Containing X-Linked Protein 22
ARM Protein Lost In Epithelial Cancers On Chromosome X 22 3     Protein ALEX23

External Ids:    HGNC: 168691   Entrez Gene: 98232   Ensembl: ENSG000001848677   OMIM: 3003635   UniProtKB: Q7L3113   

Export aliases for ARMCX2 gene to outside databases

Previous GC identifers: GC0XM099683 GC0XM100716 GC0XM100796 GC0XM090717


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARMCX2:
This gene encodes a member of the ALEX family of proteins and may play a role in tumor suppression. The encoded protein
contains a potential N-terminal transmembrane domain and a single Armadillo (arm) repeat. Other proteins containing
the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely
localized with other family members, including ALEX1 and ALEX3, on the X chromosome. Two alternative transcripts that
encode the same protein but differ in the 5' UTR have been described. Additional alternative transcripts may exist but
their full length natures have not been determined. A pseudogene for this locus is located on chromosome 7. (provided
by RefSeq, Jul 2008)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011651.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARMCX2 gene promoter:
         HFH-3   GATA-3   Tal-1   GATA-2   E47   Evi-1   FOXI1   POU2F1   POU2F1a   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARMCX2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARMCX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARMCX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq21.33-q22.2   Ensembl cytogenetic band:  Xq22.1   HGNC cytogenetic band: Xq21.33-q22.2

ARMCX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARMCX2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM100910:  view genomic region     (about GC identifiers)

Start:
100,910,267 bp from pter      End:
100,914,876 bp from pter
Size:
4,610 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ARMX2_HUMAN, Q7L311 (See protein sequence)
Recommended Name: Armadillo repeat-containing X-linked protein 2  
Size: 632 amino acids; 65683 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=BAA25438.2; Type=Erroneous initiation;
Secondary accessions: O60267 Q5H9D9

Explore the universe of human proteins at neXtProt for ARMCX2: NX_Q7L311

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7L311

  • ARMCX2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_055597.1  NP_808818.1  

    ENSEMBL proteins: 
     ENSP00000328631   ENSP00000331662   ENSP00000349281   ENSP00000412481   ENSP00000410151  
     ENSP00000393778   ENSP00000415490   ENSP00000405376  

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    Novus Biologicals ARMCX2 Lysates
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    Uscn Proteins for ARMCX2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    ARMCX2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ARMCX2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR006911 ARM-rpt_dom
     IPR011989 ARM-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q7L311

    ProtoNet protein and cluster: Q7L311

    UniProtKB/Swiss-Prot: ARMX2_HUMAN, Q7L311
    Similarity: Contains 3 ARM repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARMCX2

    1 GenomeRNAi human phenotype for ARMCX2:
     Increased G2M DNA content 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARMCX2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for ARMCX2 (Q7L3112, 3 ENSP000003286314) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VIMP086702, 3, ENSP000002242374MINT-3980387 I2D: score=3 STRING: ENSP00000224237
    HTTP428583, ENSP000003471844I2D: score=1 STRING: ENSP00000347184
    ARMCX2Q7L3112MINT-3980506
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARMCX2
    Search CenterWatch for drugs/clinical trials and news about ARMCX2 / ARMX2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARMCX2 gene (2 alternative transcripts): 
    NM_014782.5  NM_177949.2  

    Unigene Cluster for ARMCX2:

    Armadillo repeat containing, X-linked 2
    Hs.48924  [show with all ESTs]
    Unigene Representative Sequence: BC052628
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330154(uc004eid.2) ENST00000328766(uc004eie.3 uc004eif.3 uc004eig.3 uc010nnt.2)
    ENST00000356824 ENST00000413506 ENST00000433318 ENST00000440675 ENST00000458024
    ENST00000467416 ENST00000431597 ENST00000479333 ENST00000496581 ENST00000488982
    ENST00000475854

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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate ARMCX2 (see all 28):
    hsa-miR-320a hsa-miR-323-3p hsa-miR-218-2* hsa-miR-15a hsa-miR-522 hsa-miR-1297 hsa-miR-9 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidARMCX2 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AB011084.1 AK291342.1 BC012541.1 BC015926.1 BC052628.1 BX648494.1 

    13 DOTS entries:

    DT.95167731  DT.413593  DT.91754527  DT.95167730  DT.102823085  DT.100789182  DT.102823082  DT.75142113 
    DT.121279918  DT.100650107  DT.100789178  DT.102823084  DT.95167729 

    24/142 AceView cDNA sequences (see all 142):

    AL043997 CB111511 BM423413 AI471110 BE765439 CK905922 AI753648 BQ272202 
    BF345499 CA436689 AI659709 AA947030 CA392294 BP378853 AB011084 BX473058 
    NM_177949 CA391302 AW262761 BC052628 AI915723 NM_014782 AA666339 BF590275 

    GeneLoc Exon Structure

    5/29 Alternative Splicing Database (ASD) splice patterns (SP) for ARMCX2 (see all 29)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8a · 8b · 8c · 8d ·
    SP1:              -     -     -     -     -     -     -                 -     -                 -     -     -     -                                             
    SP2:                                            -     -                 -     -                 -     -     -     -                                             
    SP3:                                -     -     -     -                 -     -                 -     -     -     -                                             
    SP4:                                            -                       -     -                 -     -     -     -                                             
    SP5:                                            -     -           -     -     -                 -     -     -     -                                             

    ExUns: 8e · 8f · 8g · 8h · 8i · 8j · 8k · 8l · 8m · 8n · 8o · 8p · 8q · 8r · 8s
    SP1:                                                                                          
    SP2:                                                                                          
    SP3:                                                                                          
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for ARMCX2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARMCX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTTTGCAGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    ARMCX2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    N2/LSB induced-cells (Generation of midbra...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ARMCX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARMCX2

    SOURCE GeneReport for Unigene cluster: Hs.48924

    UniProtKB/Swiss-Prot: ARMX2_HUMAN, Q7L311
    Tissue specificity: Expressed at high levels ovary, heart, testis, prostate, brain, spleen and colon. Expressed at very
    low levels in liver and thymus. Not expressed in peripheral blood leukocytes. Not expressed in pancreas and ovarian
    carcinomas

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARMCX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ARMCX2 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ARMC106
    Uncharacterized protein
    35(a)
    1 → many
    1(13884450-13891606)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    37(a)
    1 → many
    5(95306234-95312068)
    zebrafish
    (Danio rerio)
    Actinopterygii CR391963.36
    --
    26(a)
    1 → many
    25(19368324-19378456)


    ENSEMBL Gene Tree for ARMCX2 (if available)
    TreeFam Gene Tree for ARMCX2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARMCX2 gene
    ARMCX42  GPRASP22  ARMCX12  BHLHB92  GPRASP12  ARMCX52  ARMCX62  ARMC102  
    ARMCX32  
    2 SIMAP similar genes for ARMCX2 using alignment to 5 protein entries:     ARMX2_HUMAN (see all proteins):
    ARMCX3    ARMCX1

    ARMCX2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ARMCX2
    PGOHUM00000232992


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/86 NCBI SNPs in ARMCX2 are shown (see all 86    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs31776131,2
    C,F,H--90717791(-) ACTGAC/AAAAAA 2 -- ut31 ese32Minor allele frequency- A:0.01NS NA 174
    rs20717531,2
    C,F,H,--90720589(+) ATCAAG/AAGCAG 2 -- ut51 ese37Minor allele frequency- A:0.01NS EA NA 576
    rs454691911,2
    C,--90720718(+) TTTGGA/GCCCCT 2 -- int12Minor allele frequency- G:0.33WA CSA 3
    rs1119216351,2
    --90721328(+) GAGCGA/GGGCGA 2 -- int11Minor allele frequency- G:0.00CSA 1
    rs23621611,2
    C,F,O,H,--90723851(+) ACCACT/CTGGCC 2 -- us2k123Minor allele frequency- C:0.79NS EA NA WA CSA 2553
    rs126883941,2
    H--90724312(+) AAACAA/TTAAGG 2 -- us2k1 tfbs30--------
    rs1859834061,2
    --100909854(+) TGGCTC/TGGGGT 2 -- ds50010--------
    rs1896553441,2
    --100909999(+) TCTCCA/GAAGCA 2 -- ds50010--------
    rs1822765611,2
    --100910120(+) TATATC/TTGACA 2 -- ds50010--------
    rs1880437421,2
    --100910266(+) AACGAC/TTTTTT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for ARMCX2 (100910267 - 100914876 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ARMCX2: --
    Locus Specific Mutation Databases (LSDB): ARMCX2

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARMCX2
    DNA2.0 Custom Variant and Variant Library Synthesis for ARMCX2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ARMCX2 for disorders           About GeneDecksing

    OMIM gene information: 300363    OMIM disorders: --

    4 diseases for ARMCX2:    About MalaCards
    huntington's disease    ovarian carcinoma    carcinoma    prostatitis


    Export disorders for ARMCX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARMCX2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ARMCX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas. (PubMed id 11162520)1, 2, 3, 9 Kurochkin I.V....Nomura H. (2001)
    2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2, 3 Nagase T....Ohara O. (1998)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Candidate DNA methylation drivers of acquired cisplati n resistance in ovarian cancer identified by methylome and expression profiling. (PubMed id 22249249)1 Zeller C....Brown R. (2012)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. (PubMed id 15383276)1 Goehler H....Wanker E.E. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9823 HGNC: 16869 AceView: ARMCX2 Ensembl:ENSG00000184867 euGenes: HUgn9823
    ECgene: ARMCX2 H-InvDB: ARMCX2

    (According to HUGE)
    About This Section
    HUGE: KIAA0512

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARMCX2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ARMCX2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARMCX2 gene:
    Search GeneIP for patents involving ARMCX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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