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Aliases for ARMCX1 Gene

Aliases for ARMCX1 Gene

  • Armadillo Repeat Containing, X-Linked 1 2 3 5
  • ARM Protein Lost In Epithelial Cancers On Chromosome X 1 3 4
  • ALEX1 3 4
  • Arm Protein Lost In Epithelial Cancers, X Chromosome, 1 3
  • Armadillo Repeat-Containing X-Linked Protein 1 3
  • Protein ALEX1 4
  • GASP7 3

External Ids for ARMCX1 Gene

Previous GeneCards Identifiers for ARMCX1 Gene

  • GC0XP099578
  • GC0XP100611
  • GC0XP100692
  • GC0XP100805
  • GC0XP090613

Summaries for ARMCX1 Gene

Entrez Gene Summary for ARMCX1 Gene

  • This gene encodes a member of the ALEX family of proteins and may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and two Armadillo (arm) repeats. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members, including ALEX2 and ALEX3, on the X chromosome. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARMCX1 Gene

ARMCX1 (Armadillo Repeat Containing, X-Linked 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is ARMCX2.

UniProtKB/Swiss-Prot for ARMCX1 Gene

  • Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with MIRO1.

Gene Wiki entry for ARMCX1 Gene

Additional gene information for ARMCX1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARMCX1 Gene

Genomics for ARMCX1 Gene

GeneHancer (GH) Regulatory Elements for ARMCX1 Gene

Promoters and enhancers for ARMCX1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI101549 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 550.8 +0.4 415 2.5 ZNF687 PKNOX1 USF1 RFX1 BHLHE40 MAX SIN3A USF2 MNT ZBTB7B ARMCX1 ARMCX4 ARMCX7P
GH0XI101406 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.6 -141.8 -141804 5 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 GLA HNRNPH2 PPIAP90 ARMCX4 RPL36A ARMCX1 ENSG00000261101 RPL36A-HNRNPH2
GH0XI101596 Enhancer 0.7 ENCODE 0.2 +45.7 45697 0.1 CTCF BMI1 RAD21 RELA GATA3 ZNF143 SMC3 IKZF2 RUNX3 ZNF654 ARMCX7P RNU6-30P ARMCX1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ARMCX1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ARMCX1 gene promoter:

Genomic Locations for ARMCX1 Gene

Genomic Locations for ARMCX1 Gene
chrX:101,550,531-101,554,700
(GRCh38/hg38)
Size:
4,170 bases
Orientation:
Plus strand
chrX:100,805,514-100,809,683
(GRCh37/hg19)

Genomic View for ARMCX1 Gene

Genes around ARMCX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARMCX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARMCX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARMCX1 Gene

Proteins for ARMCX1 Gene

  • Protein details for ARMCX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P291-ARMX1_HUMAN
    Recommended name:
    Armadillo repeat-containing X-linked protein 1
    Protein Accession:
    Q9P291
    Secondary Accessions:
    • Q53HK2
    • Q9H2Q0

    Protein attributes for ARMCX1 Gene

    Size:
    453 amino acids
    Molecular mass:
    49180 Da
    Quaternary structure:
    • Interacts with MIRO1.
    SequenceCaution:
    • Sequence=AAG44561.1; Type=Frameshift; Positions=357, 370; Evidence={ECO:0000305};

neXtProt entry for ARMCX1 Gene

Post-translational modifications for ARMCX1 Gene

No Post-translational modifications

Other Protein References for ARMCX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARMCX1 Gene

Domains & Families for ARMCX1 Gene

Gene Families for ARMCX1 Gene

Protein Domains for ARMCX1 Gene

Suggested Antigen Peptide Sequences for ARMCX1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P291

UniProtKB/Swiss-Prot:

ARMX1_HUMAN :
  • Belongs to the eutherian X-chromosome-specific Armcx family.
Family:
  • Belongs to the eutherian X-chromosome-specific Armcx family.
genes like me logo Genes that share domains with ARMCX1: view

Function for ARMCX1 Gene

Molecular function for ARMCX1 Gene

UniProtKB/Swiss-Prot Function:
Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with MIRO1.

Gene Ontology (GO) - Molecular Function for ARMCX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ARMCX1: view

Phenotypes for ARMCX1 Gene

genes like me logo Genes that share phenotypes with ARMCX1: view

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ARMCX1 Gene

Localization for ARMCX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARMCX1 Gene

Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARMCX1 gene
Compartment Confidence
mitochondrion 4
endoplasmic reticulum 2
cytosol 2
extracellular 1
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARMCX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ARMCX1: view

Pathways & Interactions for ARMCX1 Gene

SuperPathways for ARMCX1 Gene

No Data Available

Interacting Proteins for ARMCX1 Gene

Gene Ontology (GO) - Biological Process for ARMCX1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ARMCX1 Gene

Drugs & Compounds for ARMCX1 Gene

No Compound Related Data Available

Transcripts for ARMCX1 Gene

mRNA/cDNA for ARMCX1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(117) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARMCX1 Gene

Armadillo repeat containing, X-linked 1:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARMCX1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - -
SP2: - - -
SP3: - -
SP4: - - - -
SP5: - -
SP6: -
SP7: -

Relevant External Links for ARMCX1 Gene

GeneLoc Exon Structure for
ARMCX1
ECgene alternative splicing isoforms for
ARMCX1

Expression for ARMCX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARMCX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARMCX1 Gene

This gene is overexpressed in Bone (13.1), Lymph node (10.9), Pancreatic juice (8.9), and Ovary (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARMCX1 Gene



NURSA nuclear receptor signaling pathways regulating expression of ARMCX1 Gene:

ARMCX1

SOURCE GeneReport for Unigene cluster for ARMCX1 Gene:

Hs.9728

mRNA Expression by UniProt/SwissProt for ARMCX1 Gene:

Q9P291-ARMX1_HUMAN
Tissue specificity: Expressed at high levels ovary, heart, testis, prostate, brain, spleen and colon. Expressed at very low levels in liver and thymus. Not expressed in peripheral blood leukocytes. Not or reduced expressed in lung, prostate, colon, pancreas and ovarian carcinomas.

Evidence on tissue expression from TISSUES for ARMCX1 Gene

  • Adrenal gland(4.3)
  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with ARMCX1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARMCX1 Gene

Orthologs for ARMCX1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ARMCX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARMCX1 33 34
  • 99.85 (n)
dog
(Canis familiaris)
Mammalia ARMCX1 33 34
  • 88.05 (n)
cow
(Bos Taurus)
Mammalia ARMCX1 33 34
  • 87.93 (n)
mouse
(Mus musculus)
Mammalia Armcx1 33 16 34
  • 83.75 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 45 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 38 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 35 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ARMCX3 34
  • 29 (a)
OneToMany
Species where no ortholog for ARMCX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARMCX1 Gene

ENSEMBL:
Gene Tree for ARMCX1 (if available)
TreeFam:
Gene Tree for ARMCX1 (if available)

Paralogs for ARMCX1 Gene

Paralogs for ARMCX1 Gene

(5) SIMAP similar genes for ARMCX1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARMCX1: view

Variants for ARMCX1 Gene

Sequence variations from dbSNP and Humsavar for ARMCX1 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000683827 -- 101,552,196(+) A/G intron_variant
rs1000709469 -- 101,554,625(+) A/G 3_prime_UTR_variant
rs1001011875 -- 101,552,493(+) A/C intron_variant
rs1001442610 -- 101,554,230(+) C/T coding_sequence_variant, synonymous_variant
rs1001512758 -- 101,553,492(+) C/T coding_sequence_variant, missense_variant

Variation tolerance for ARMCX1 Gene

Residual Variation Intolerance Score: 12.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ARMCX1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARMCX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARMCX1 Gene

Disorders for ARMCX1 Gene

Additional Disease Information for ARMCX1

No disorders were found for ARMCX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARMCX1 Gene

Publications for ARMCX1 Gene

  1. ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas. (PMID: 11162520) Kurochkin IV … Nomura H (Biochemical and biophysical research communications 2001) 2 3 4 22 58
  2. The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2. (PMID: 22569362) López-Doménech G … Soriano E (Nature communications 2012) 2 3 58
  3. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter EE … Ponting CP (BMC evolutionary biology 2005) 2 3 58
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for ARMCX1 Gene

Sources for ARMCX1 Gene

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