ARMCX1 Gene
protein-coding GIFtS: 47
GCID: GC0XP100805
|
|
armadillo repeat containing, X-linked 1
| |
Aliases
for ARMCX1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Armadillo Repeat Containing, X-Linked 11 2 | | ALEX11 2 3 5 | | ARM Protein Lost In Epithelial Cancers On Chromosome X 12 3 | | Arm Protein Lost In Epithelial Cancers, X Chromosome, 12 | | Armadillo Repeat-Containing X-Linked Protein 12 | | Protein ALEX13 |
Export aliases for ARMCX1 gene to outside databasesPrevious GC identifers: GC0XP099578 GC0XP100611 GC0XP100692 GC0XP090613 |
Summaries
for ARMCX1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ARMCX1:
This gene encodes a member of the ALEX family of proteins and may play a role in tumor suppression. The encoded proteincontains a potential N-terminal transmembrane domain and two Armadillo (arm) repeats. Other proteins containing thearm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closelylocalized with other family members, including ALEX2 and ALEX3, on the X chromosome. (provided by RefSeq, Jul 2008)
Gene Wiki entry for ARMCX1
|
Genomic Views
for ARMCX1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011651.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ARMCX1 gene promoter:
GR C/EBPbeta STAT1 AML1a Nkx2-5 MZF-1 Pax-3 SRY POU2F1a GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARMCX1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARMCX1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq21.33-q22.2 Ensembl cytogenetic band: Xq22.1 HGNC cytogenetic band: Xq21.33-q22.2ARMCX1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP100805: view genomic region
(about GC identifiers)
Start:
|
100,805,514 bp from pter |
End:
|
100,809,683 bp from pter |
Size:
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4,170 bases |
Orientation:
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plus strand |
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Proteins
for ARMCX1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ARMX1_HUMAN, Q9P291 (See
protein sequence)Recommended Name: Armadillo repeat-containing X-linked protein 1 Size: 453 amino acids; 49180 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=AAG44561.1; Type=Frameshift; Positions=357, 370;
Secondary accessions: Q53HK2 Q9H2Q0Explore the universe of human proteins at neXtProt for ARMCX1: NX_Q9P291
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9P291
ARMCX1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057692.1
ENSEMBL proteins: ENSP00000361917
Human Recombinant Protein Products for ARMCX1:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
ARMCX1 for ontologies About GeneDecksing
ARMCX1 Antibody Products:
Assay Products for ARMCX1: |
Protein
Domains /
Families
for ARMCX1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARMCX1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9P291ProtoNet protein and cluster: Q9P291 UniProtKB/Swiss-Prot: ARMX1_HUMAN, Q9P291Similarity: Contains 3 ARM repeats |
Function
for ARMCX1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARMCX1 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARMCX1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARMCX1 |
|
Pathways & Interactions
for ARMCX1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARMCX1
|
Drugs & Compounds
for ARMCX1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ARMCX1
Search CenterWatch for drugs/clinical trials and news about ARMCX1 / ARMX1
|
Transcripts
for ARMCX1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ARMCX1 gene: NM_016608.1 Unigene Cluster for ARMCX1: Armadillo repeat containing, X-linked 1 Hs.9728 [show with all ESTs]Unigene Representative Sequence: AB0396701 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000372829(uc004ehv.3 uc004ehw.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARMCX1 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARMCX1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ARMCX1 (NM_016608) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARMCX1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARMCX1 |
Additional cDNA sequence: AB039670.1 AF248963.1 AK074785.1 AK222578.1 BC002691.2 CR749609.1 8 DOTS entries: DT.413312 DT.121279997 DT.121280005 DT.95265219 DT.100747808 DT.121280044 DT.121280046 DT.121280048 24/117 AceView cDNA sequences (see all 117): BM922285 BU741213 AI949956 BQ894066 AV706716 AA666418 AI951939 BC002691 AA227428 AA886403 H04746 BP380387 BM679530 F10236 AB039670 BQ018891 BM726945 AW952052 CR616090 CR749609 T65040 BQ772949 AA348461 Z40853
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ARMCX1 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f |
|---|
|
| SP1: | | | | | | | | | - | | | | - | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ARMCX1
|
Expression
for ARMCX1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARMCX1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATAAGCTAC
About this image
See ARMCX1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARMCX1
SOURCE GeneReport for Unigene cluster: Hs.9728
UniProtKB/Swiss-Prot: ARMX1_HUMAN, Q9P291Tissue specificity: Expressed at high levels ovary, heart, testis, prostate, brain, spleen and colon. Expressed at verylow levels in liver and thymus. Not expressed in peripheral blood leukocytes. Not or reduced expressed in lung,prostate, colon, pancreas and ovarian carcinomas
SABiosciences Custom PCR Arrays for ARMCX1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARMCX1
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARMCX1 |
Orthologs
for ARMCX1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ARMCX1 gene from 3/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ARMC106 |
Uncharacterized protein |
38(a) |
1 → many |
1(13884450-13891606) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
40(a) |
1 → many |
5(95306234-95312068) |
zebrafish
(Danio rerio) |
Actinopterygii |
CR391963.36 |
-- |
27(a) |
1 → many |
25(19368324-19378456) |
ENSEMBL Gene Tree for ARMCX1 (if available)
TreeFam Gene Tree for ARMCX1 (if available) |
Paralogs
for ARMCX1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ARMCX1 gene
- ARMCX42 GPRASP22 BHLHB92 ARMCX22 GPRASP12 ARMCX52 ARMCX62 ARMC102
- ARMCX32
5 SIMAP similar genes for ARMCX1 using alignment to 1 protein entry: ARMX1_HUMAN:DKFZp686P06199 ARMC10 ARMCX2 ARMCX3 ARMCX4
ARMCX1 for paralogs About GeneDecksing
|
Genomic Variants
for ARMCX1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ARMCX1 (100805514 - 100809683 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ARMCX1
1 CNV: 96857
Locus Specific Mutation Databases (LSDB): ARMCX1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARMCX1 |
|
Disorders
/ Diseases
for ARMCX1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ARMCX1 for disorders About GeneDecksing
OMIM gene information: 300362
OMIM disorders: --
3  diseases for ARMCX1: About MalaCardsovarian carcinoma carcinoma prostatitis
Export disorders for ARMCX1 gene to outside databases
|
Publications
for ARMCX1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARMCX1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ARMCX1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas. (PubMed id 11162520)1, 2, 3, 9 Kurochkin I.V....Nomura H. (2001)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Human Arm protein lost in epithelial cancers, on chro mosome X 1 (ALEX1) gene is transcriptionally regulated by CREB and Wnt/beta-cat enin signaling. (PubMed id 20398052)1 Iseki H....Koyama I. (2010)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
|
External Searches for ARMCX1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ARMCX1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ARMCX1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ARMCX1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ARMCX1 gene:
Search GeneIP for patents involving ARMCX1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ARMCX1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARMCX1 |
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