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Aliases for ARMCX1 Gene

Aliases for ARMCX1 Gene

  • Armadillo Repeat Containing, X-Linked 1 2 3 5
  • ARM Protein Lost In Epithelial Cancers On Chromosome X 1 3 4
  • ALEX1 3 4
  • Arm Protein Lost In Epithelial Cancers, X Chromosome, 1 3
  • Protein ALEX1 4
  • GASP7 3

External Ids for ARMCX1 Gene

Previous GeneCards Identifiers for ARMCX1 Gene

  • GC0XP099578
  • GC0XP100611
  • GC0XP100692
  • GC0XP100805
  • GC0XP090613

Summaries for ARMCX1 Gene

Entrez Gene Summary for ARMCX1 Gene

  • This gene encodes a member of the ALEX family of proteins and may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and two Armadillo (arm) repeats. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members, including ALEX2 and ALEX3, on the X chromosome. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARMCX1 Gene

ARMCX1 (Armadillo Repeat Containing, X-Linked 1) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is ARMCX6.

Gene Wiki entry for ARMCX1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARMCX1 Gene

Genomics for ARMCX1 Gene

Regulatory Elements for ARMCX1 Gene

Enhancers for ARMCX1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARMCX1 on UCSC Golden Path with GeneCards custom track

Promoters for ARMCX1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARMCX1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARMCX1 Gene

101,550,531 bp from pter
101,554,700 bp from pter
4,170 bases
Plus strand

Genomic View for ARMCX1 Gene

Genes around ARMCX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARMCX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARMCX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARMCX1 Gene

Proteins for ARMCX1 Gene

  • Protein details for ARMCX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Armadillo repeat-containing X-linked protein 1
    Protein Accession:
    Secondary Accessions:
    • Q53HK2
    • Q9H2Q0

    Protein attributes for ARMCX1 Gene

    453 amino acids
    Molecular mass:
    49180 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG44561.1; Type=Frameshift; Positions=357, 370; Evidence={ECO:0000305};

neXtProt entry for ARMCX1 Gene

Proteomics data for ARMCX1 Gene at MOPED

Post-translational modifications for ARMCX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARMCX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARMCX1 Gene

Domains & Families for ARMCX1 Gene

Gene Families for ARMCX1 Gene

Protein Domains for ARMCX1 Gene

Suggested Antigen Peptide Sequences for ARMCX1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 ARM repeats.
  • Contains 3 ARM repeats.
genes like me logo Genes that share domains with ARMCX1: view

Function for ARMCX1 Gene

Phenotypes for ARMCX1 Gene

genes like me logo Genes that share phenotypes with ARMCX1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ARMCX1 Gene

Localization for ARMCX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARMCX1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ARMCX1 Gene COMPARTMENTS Subcellular localization image for ARMCX1 gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 2
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ARMCX1 Gene

Pathways & Interactions for ARMCX1 Gene

SuperPathways for ARMCX1 Gene

No Data Available

Interacting Proteins for ARMCX1 Gene

Selected Interacting proteins: Q9P291-ARMX1_HUMAN for ARMCX1 Gene via UniProtKB

Gene Ontology (GO) - Biological Process for ARMCX1 Gene


No data available for Pathways by source and SIGNOR curated interactions for ARMCX1 Gene

Drugs & Compounds for ARMCX1 Gene

No Compound Related Data Available

Transcripts for ARMCX1 Gene

mRNA/cDNA for ARMCX1 Gene

Unigene Clusters for ARMCX1 Gene

Armadillo repeat containing, X-linked 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARMCX1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - -
SP2: - - -
SP3: - -
SP4: - - - -
SP5: - -
SP6: -
SP7: -

Relevant External Links for ARMCX1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARMCX1 Gene

mRNA expression in normal human tissues for ARMCX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARMCX1 Gene

This gene is overexpressed in Bone (13.1), Lymph node (10.9), Pancreatic juice (8.9), and Ovary (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ARMCX1 Gene

SOURCE GeneReport for Unigene cluster for ARMCX1 Gene Hs.9728

mRNA Expression by UniProt/SwissProt for ARMCX1 Gene

Tissue specificity: Expressed at high levels ovary, heart, testis, prostate, brain, spleen and colon. Expressed at very low levels in liver and thymus. Not expressed in peripheral blood leukocytes. Not or reduced expressed in lung, prostate, colon, pancreas and ovarian carcinomas.
genes like me logo Genes that share expression patterns with ARMCX1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for ARMCX1 Gene

Orthologs for ARMCX1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ARMCX1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARMCX1 35
  • 87.93 (n)
  • 85.42 (a)
  • 86 (a)
(Canis familiaris)
Mammalia ARMCX1 35
  • 88.05 (n)
  • 88.36 (a)
  • 87 (a)
(Mus musculus)
Mammalia Armcx1 35
  • 83.75 (n)
  • 84.51 (a)
Armcx1 16
Armcx1 36
  • 84 (a)
(Pan troglodytes)
Mammalia ARMCX1 35
  • 99.85 (n)
  • 99.56 (a)
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 45 (a)
(Gallus gallus)
Aves -- 36
  • 38 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 35 (a)
(Danio rerio)
Actinopterygii ARMCX3 36
  • 29 (a)
Species with no ortholog for ARMCX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARMCX1 Gene

Gene Tree for ARMCX1 (if available)
Gene Tree for ARMCX1 (if available)

Paralogs for ARMCX1 Gene

Paralogs for ARMCX1 Gene

(5) SIMAP similar genes for ARMCX1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARMCX1: view

Variants for ARMCX1 Gene

Sequence variations from dbSNP and Humsavar for ARMCX1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1044275 -- 101,553,239(+) GGTGG(C/T)CTAGA reference, synonymous-codon
rs5951352 -- 101,554,962(+) TGGGA(A/C)TCCTT downstream-variant-500B
rs5991945 -- 101,552,243(-) ATCAT(A/C/G/T)GAAGG intron-variant
rs6616255 -- 101,552,926(+) CAGCT(A/G)TACCA utr-variant-5-prime
rs6621104 -- 101,548,729(+) atggc(A/G)tttta upstream-variant-2KB

Variation tolerance for ARMCX1 Gene

Residual Variation Intolerance Score: 12.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.13% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ARMCX1 Gene

Disorders for ARMCX1 Gene

Relevant External Links for ARMCX1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARMCX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARMCX1 Gene

Publications for ARMCX1 Gene

  1. ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas. (PMID: 11162520) Kurochkin I.V. … Nomura H. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 23 67
  2. The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2. (PMID: 22569362) LA^pez-DomAcnech G. … Soriano E. (Nat Commun 2012) 2 3
  3. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter E.E. … Ponting C.P. (BMC Evol. Biol. 2005) 2 3
  4. ALEX1 Regulates Proliferation and Apoptosis in Breast Cancer Cells. (PMID: 25921134) Gao Y. … Song F.Z. (Asian Pac. J. Cancer Prev. 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for ARMCX1 Gene

Sources for ARMCX1 Gene