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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ARMC9 Gene

protein-coding GIFtS: 46
GCID: GC02P232064

armadillo repeat containing 9

Explore 6 diseases affiliated with
ARMC9 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Armadillo Repeat Containing 9¹ ²		NS21² ³
ARM¹ ²		FLJ12584¹
KU-MEL-1¹ ²		Armadillo/Beta-Catenin-Like Repeats²
KIAA1868¹ ³		LisH Domain-Containing Protein ARMC9²
Melanoma/Melanocyte-Specific Tumor Antigen KU-MEL-1² ³		Melanoma/Melanocyte Specific Protein KU-MEL-1²

External Ids:	HGNC: 20730¹	Entrez Gene: 80210²	Ensembl: ENSG00000135931⁷	UniProtKB: Q7Z3E5³

Export aliases for ARMC9 gene to outside databases

Previous GC identifers: GC02P231889 GC02P231771 GC02P223905

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for ARMC9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ARMC9 gene promoter:
AhR TBP STAT1 GATA-3 STAT5A HNF-4alpha2 HNF-4alpha1 N-Myc FOXJ2 (long isoform) FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ARMC9 promoter sequence

Search SABiosciences Chromatin IP Primers for ARMC9

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARMC9

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1 Ensembl cytogenetic band: 2q37.1 HGNC cytogenetic band: 2q37.1

ARMC9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARMC9 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P232064: view genomic region (about GC identifiers)

Start:	232,063,260 bp from pter	End:	232,239,548 bp from pter
Size:	176,289 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ARMC9_HUMAN, Q7Z3E5 (See protein sequence)

Recommended Name: LisH domain-containing protein ARMC9

Size: 817 amino acids; 91762 Da

Sequence caution: Sequence=BAB14153.1; Type=Erroneous initiation;

Secondary accessions: Q53TI3 Q6P162 Q7L594 Q86WG2 Q96JF9 Q9H9R8

Alternative splicing: 2 isoforms: Q7Z3E5-1 Q7Z3E5-2

Explore the universe of human proteins at neXtProt for ARMC9: NX_Q7Z3E5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q7Z3E5

ARMC9 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001258395.1 NP_079415.3

ENSEMBL proteins:

ENSP00000258417 ENSP00000387391 ENSP00000407146 ENSP00000392086 ENSP00000413932

ENSP00000411778 ENSP00000388527

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ARMC9 for domains About GeneDecksing

3 InterPro domains/families:

IPR011989 ARM-like

IPR016024 ARM-type_fold

IPR006594 LisH_dimerisation

Graphical View of Domain Structure for InterPro Entry Q7Z3E5

ProtoNet protein and cluster: Q7Z3E5

1 Blocks protein family: IPB006594 Lissencephaly type-1-like homology motif

UniProtKB/Swiss-Prot: ARMC9_HUMAN, Q7Z3E5

Similarity: Contains 1 LisH domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ARMC9

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for ARMC9 gene (2 alternative transcripts):

NM_001271466.1 NM_025139.4

Unigene Cluster for ARMC9:

Armadillo repeat containing 9

Hs.471610 [show with all ESTs]

Unigene Representative Sequence: NM_001271466

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000349938(uc002vrq.4 uc002vrp.4) ENST00000482392 ENST00000440107

ENST00000483477(uc002vrr.1) ENST00000469789 ENST00000444285 ENST00000436339

ENST00000467698 ENST00000424740 ENST00000446447 ENST00000481520 ENST00000428662

ENST00000486787 ENST00000488821

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Additional cDNA sequence:

AB058771.1 AK022646.1 AK309395.1 AY219922.1 AY929062.1 BC004514.2 BC065271.1 BX537956.1

13 DOTS entries:

DT.87015163 DT.95210377 DT.86857823 DT.40207557 DT.105733 DT.100638454 DT.97858546 DT.120993262

DT.209017 DT.40129282 DT.100782611 DT.92424788 DT.99993407

24/117 AceView cDNA sequences (see all 117):

CA427360 BX111921 AI741507 AI274627 BC017229 AI342531 CN479949 Z38862

BM990717 BQ423528 BM723527 BM685292 AA309729 BM835538 BM988551 CR608697

AB058771 F05933 BX537956 BX103854 AK027163 BG766944 AA969954 BE874313

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ARMC9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCAACACGG

About this image
See ARMC9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARMC9

SOURCE GeneReport for Unigene cluster: Hs.471610

UniProtKB/Swiss-Prot: ARMC9_HUMAN, Q7Z3E5

Tissue specificity: Strongly expressed in most melanomas and melanocytes. Weakly expressed in the testis

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ARMC9 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Armc9^{1 , 5}	armadillo repeat containing 9^{1, 5}	87.32(n)¹ 92.33(a)¹		1 (43.94 cM)⁵ 78795¹ NM_030184.2¹ NP_084460.1¹ 86154780⁵
chicken (Gallus gallus)	Aves	ARMC9¹	armadillo repeat containing 9	75.6(n) 79.82(a)		424929 XM_422737.3 XP_422737.3
lizard (Anolis carolinensis)	Reptilia	ARMC9⁶	--	76(a)	1 ↔ 1	GL343433.1(647049-733312)
zebrafish (Danio rerio)	Actinopterygii	AL918635.1²	--	75.2(n)		AL918635.1
honey bee (Apis mellifera)	Insecta	--	--	25(a)	1 ↔ 1	GroupUn.222(16108-20885)
worm (Caenorhabditis elegans)	Secernentea	F59G1.4⁶	F59G1.4; Protein F59G1.4	16(a)	1 ↔ 1	II(5896147-5904565)

ENSEMBL Gene Tree for ARMC9 (if available)
TreeFam Gene Tree for ARMC9 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79536953^1,2	F,	--	232061311(+)	`GTTCAC/TGGCAG`	2	--	us2k¹		3		CSA WA	122
rs142286636^1,2		--	232061428(+)	`TCTTGC/TCAAAG`	2	--	us2k¹		0	--	--	--	--
rs62197322^1,2	C,F,	--	232061520(+)	`GGCAGA/GCTCAG`	2	--	us2k¹		7		WA NA CSA EA	366
rs192738727^1,2		--	232061538(+)	`GGAAAA/TGGTCT`	2	--	us2k¹		0	--	--	--	--
rs116703741^1,2		--	232061556(+)	`TCCTTG/ATCACA`	2	--	us2k¹		1		WA	118
rs184319203^1,2		--	232061692(+)	`TGGAGA/GATTTT`	2	--	us2k¹		0	--	--	--	--
rs146101005^1,2		--	232061780(+)	`AATTAC/TAACAT`	2	--	us2k¹		0	--	--	--	--
rs145723812^1,2		--	232061798(+)	`CAGTAA/TAATGC`	2	--	us2k¹		0	--	--	--	--
rs112007540^1,2		--	232061966(+)	`CTTCCG/CGAGTG`	2	--	us2k¹		1		CSA	2
rs6753393^1,2	C,A,	--	232061967(+)	`TTCCCG/CAGTGG`	2	--	us2k¹		4		NA EA	244

HapMap Linkage Disequilibrium report for ARMC9 (232063260 - 232239548 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ARMC9
1 Indel: 45961

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ARMC9 for disorders About GeneDecksing

6 diseases for ARMC9: About MalaCards

vogt-koyanagi-harada disease mucopolysaccharidosis iii melanoma mucopolysaccharidosis

lissencephaly vitiligo

1 disease from the University of Copenhagen DISEASES database for ARMC9:

Mucopolysaccharidosis III

Human Genome Epidemiology (HuGE) Navigator: ARMC9 (4 documents)

Export disorders for ARMC9 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ARMC9 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with ARMC9)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)^{1, 2, 3} Nagase T.... Ohara O. (2001)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Tumor antigens isolated from a patient with vitiligo and T-cell- infiltrated melanoma. (PubMed id 11691810)^{1, 2} Kiniwa Y.... Kawakami Y. (2001)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 80210	HGNC: 20730	AceView: FLJ12584	Ensembl:ENSG00000135931	euGenes: HUgn80210
ECgene: ARMC9	H-InvDB: ARMC9

(According to HUGE)
About This Section

HUGE: KIAA1868

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ARMC9	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ARMC9	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ARMC9 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ARMC9 gene:
Search GeneIP for patents involving ARMC9

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ARMC9 gene at Home site.

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ARMC9 Gene

armadillo repeat containing 9

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ARMC9 Gene

armadillo repeat containing 9

Aliasesfor ARMC9 gene

Summariesfor ARMC9 gene

Genomic Viewsfor ARMC9 gene

Proteinsfor ARMC9 gene

Protein Domains /Familiesfor ARMC9 gene

Functionfor ARMC9 gene

Pathways & Interactionsfor ARMC9 gene

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Specialized Databases showing ARMC9 gene

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for ARMC9 gene

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for ARMC9 gene

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for ARMC9 gene

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for ARMC9 gene

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