Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ARMC8 Gene

Aliases for ARMC8 Gene

  • Armadillo Repeat Containing 8 2 3
  • GID Complex Subunit 5, VID28 Homolog 3
  • VID28 Homolog (S. Cerevisiae) 2
  • GID Complex Subunit 5 2
  • HSPC056 3
  • S863-2 3
  • VID28 3
  • GID5 3

External Ids for ARMC8 Gene

Previous GeneCards Identifiers for ARMC8 Gene

  • GC03P139389
  • GC03P137906
  • GC03P135282

Summaries for ARMC8 Gene

GeneCards Summary for ARMC8 Gene

ARMC8 (Armadillo Repeat Containing 8) is a Protein Coding gene. GO annotations related to this gene include binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARMC8 Gene

Genomics for ARMC8 Gene

Regulatory Elements for ARMC8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARMC8 Gene

138,187,248 bp from pter
138,298,389 bp from pter
111,142 bases
Plus strand

Genomic View for ARMC8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARMC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARMC8 Gene

Proteins for ARMC8 Gene

  • Protein details for ARMC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Armadillo repeat-containing protein 8
    Protein Accession:
    Secondary Accessions:
    • A8K0L2
    • B7Z441
    • B7Z453
    • D3DNE6
    • F5GWK4
    • Q6PIL2
    • Q96D19
    • Q96HZ5
    • Q9NV02
    • Q9NV94
    • Q9Y4R9

    Protein attributes for ARMC8 Gene

    673 amino acids
    Molecular mass:
    75509 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91861.1; Type=Frameshift; Positions=468; Evidence={ECO:0000305}; Sequence=BAA91959.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAB46423.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARMC8 Gene

neXtProt entry for ARMC8 Gene

Proteomics data for ARMC8 Gene at MOPED

Post-translational modifications for ARMC8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARMC8 Gene

Domains & Families for ARMC8 Gene

Gene Families for ARMC8 Gene

Protein Domains for ARMC8 Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 14 ARM repeats.
  • Contains 14 ARM repeats.
genes like me logo Genes that share domains with ARMC8: view

Function for ARMC8 Gene

Gene Ontology (GO) - Molecular Function for ARMC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ARMC8: view

Phenotypes for ARMC8 Gene

MGI mutant phenotypes for ARMC8:
inferred from 1 alleles
GenomeRNAi human phenotypes for ARMC8:
genes like me logo Genes that share phenotypes with ARMC8: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARMC8

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ARMC8 Gene

Localization for ARMC8 Gene

Subcellular locations from

Jensen Localization Image for ARMC8 Gene COMPARTMENTS Subcellular localization image for ARMC8 gene
Compartment Confidence
cytosol 2
nucleus 2
endosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ARMC8 Gene

Pathways & Interactions for ARMC8 Gene

SuperPathways for ARMC8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARMC8 Gene


No data available for Pathways by source and SIGNOR curated interactions for ARMC8 Gene

Drugs & Compounds for ARMC8 Gene

No Compound Related Data Available

Transcripts for ARMC8 Gene

Unigene Clusters for ARMC8 Gene

Armadillo repeat containing 8:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARMC8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARMC8 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^
SP1: - - - - - - - - - -
SP2: -
SP3: - - - -
SP4: -
SP5: - -
SP6: - - -
SP7: - - -
SP8: - -
SP9: - - - - - -

ExUns: 15 ^ 16

Relevant External Links for ARMC8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARMC8 Gene

mRNA expression in normal human tissues for ARMC8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARMC8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.2), Testis (8.5), and Heart (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ARMC8 Gene

SOURCE GeneReport for Unigene cluster for ARMC8 Gene Hs.744868

genes like me logo Genes that share expression patterns with ARMC8: view

Protein tissue co-expression partners for ARMC8 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARMC8 Gene

Orthologs for ARMC8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARMC8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARMC8 35
  • 95.8 (n)
  • 99.24 (a)
ARMC8 36
  • 97 (a)
(Canis familiaris)
Mammalia ARMC8 35
  • 96.35 (n)
  • 99.7 (a)
ARMC8 36
  • 97 (a)
(Mus musculus)
Mammalia Armc8 35
  • 92.96 (n)
  • 98.78 (a)
Armc8 16
Armc8 36
  • 97 (a)
(Pan troglodytes)
Mammalia ARMC8 35
  • 99.82 (n)
  • 99.73 (a)
ARMC8 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Armc8 35
  • 92.15 (n)
  • 98.63 (a)
(Monodelphis domestica)
Mammalia ARMC8 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia ARMC8 36
  • 98 (a)
(Gallus gallus)
Aves ARMC8 35
  • 84.5 (n)
  • 94.83 (a)
ARMC8 36
  • 93 (a)
(Anolis carolinensis)
Reptilia ARMC8 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia armc8 35
  • 79.32 (n)
  • 94.28 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3735 35
(Danio rerio)
Actinopterygii armc8 35
  • 74.06 (n)
  • 86.63 (a)
armc8 36
  • 85 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006626 35
  • 50.34 (n)
  • 43.86 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G51350 35
  • 42.36 (n)
  • 29.64 (a)
(Oryza sativa)
Liliopsida Os11g0638900 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2222 36
  • 39 (a)
Species with no ortholog for ARMC8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARMC8 Gene

Gene Tree for ARMC8 (if available)
Gene Tree for ARMC8 (if available)

Paralogs for ARMC8 Gene Pseudogenes for ARMC8 Gene

genes like me logo Genes that share paralogs with ARMC8: view

No data available for Paralogs for ARMC8 Gene

Variants for ARMC8 Gene

Sequence variations from dbSNP and Humsavar for ARMC8 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs3597 -- 138,245,642(-) GCACA(G/T)TAGCA intron-variant, utr-variant-3-prime
rs167908 -- 138,185,650(+) TTCGT(A/T)CAACA upstream-variant-2KB
rs170652 -- 138,194,244(+) ttcac(C/T)gtgtt intron-variant
rs329387 -- 138,186,011(+) TAGTT(A/G)ATGTG upstream-variant-2KB
rs434009 -- 138,195,746(-) TTCAG(G/T)GAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARMC8 Gene

Variant ID Type Subtype PubMed ID
nsv428422 CNV Gain+Loss 18775914
dgv1511e1 CNV Complex 17122850
dgv1512e1 CNV Complex 17122850
nsv877536 CNV Gain 21882294
nsv4030 CNV Insertion 18451855
nsv877537 CNV Gain 21882294
nsv822263 CNV Loss 20364138
nsv822264 CNV Loss 20364138

Variation tolerance for ARMC8 Gene

Residual Variation Intolerance Score: 12.36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARMC8 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARMC8 Gene

Disorders for ARMC8 Gene

Relevant External Links for ARMC8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ARMC8: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARMC8 Gene

Publications for ARMC8 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Armc8 expression was elevated during atypia-to-carcinoma progression and associated with cancer development of breast carcinoma. (PMID: 25119601) Fan C. … Wang E. (Tumour Biol. 2014) 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. ARMC8I+ promotes proliferation and invasion of non-small cell lung cancer cells by activating the canonical Wnt signaling pathway. (PMID: 24894675) Xie C. … Wang E. (Tumour Biol. 2014) 67

Products for ARMC8 Gene

Sources for ARMC8 Gene

Back to Top