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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARMC6 Gene

protein-coding   GIFtS: 46
GCID: GC19P019144

armadillo repeat containing 6

 Explore 2 diseases affiliated with
ARMC6 via our new
 Human Malady Compendium 
Biological research products
for ARMC6
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Armadillo Repeat Containing 61 2
MGC195951
R30923_12
Armadillo Repeat-Containing Protein 62

External Ids:    HGNC: 250491   Entrez Gene: 934362   Ensembl: ENSG000001056767   UniProtKB: Q6NXE63   

Export aliases for ARMC6 gene to outside databases

Previous GC identifers: GC19P019006 GC19P018708


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARMC6:
The function of this gene's protein product has not been determined. A related protein in mouse suggests that this
protein has a conserved function. Two transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Nov 2010)

Gene Wiki entry for ARMC6


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARMC6 gene promoter:
         NF-1/L   NF-1   Pax-5   GCNF   IRF-1   Gfi-1   YY1   C/EBPalpha   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARMC6 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARMC6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARMC6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13

ARMC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARMC6 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P019144:  view genomic region     (about GC identifiers)

Start:
19,144,384 bp from pter      End:
19,170,563 bp from pter
Size:
26,180 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ARMC6_HUMAN, Q6NXE6 (See protein sequence)
Recommended Name: Armadillo repeat-containing protein 6  
Size: 501 amino acids; 54142 Da
Caution: It is uncertain whether Met-1 or Met-26 is the initiator
Sequence caution: Sequence=AAD03162.1; Type=Erroneous gene model prediction; Sequence=AAH67125.1; Type=Erroneous
initiation; Note=Translation N-terminally extended;
Secondary accessions: B4DI98 O94999 Q9BTH5
Alternative splicing: 2 isoforms:  Q6NXE6-1   Q6NXE6-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for ARMC6: NX_Q6NXE6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6NXE6

  • ARMC6 Protein expression data from MOPED and PaxDb:    About this image 
    ARMC6 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001186125.1  NP_219483.1  

    ENSEMBL proteins: 
     ENSP00000376147   ENSP00000444156   ENSP00000441948   ENSP00000442263   ENSP00000446209  
     ENSP00000269932   ENSP00000444341   ENSP00000439269   ENSP00000439038   ENSP00000446037  
     ENSP00000441420   ENSP00000439003   ENSP00000444317   ENSP00000437580   ENSP00000441583  
     ENSP00000438369   ENSP00000376148   ENSP00000444916   ENSP00000446234   ENSP00000444265  
     ENSP00000443719  

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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ARMC6 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011989 ARM-like
     IPR000225 Armadillo
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q6NXE6

    ProtoNet protein and cluster: Q6NXE6

    1 Blocks protein family: IPB000225 Armadillo repeat

    UniProtKB/Swiss-Prot: ARMC6_HUMAN, Q6NXE6
    Similarity: Belongs to the ARMC6 family
    Similarity: Contains 4 ARM repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ARMC6 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARMC6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/15 Interacting proteins for ARMC6 (Q6NXE63 ENSP000002699324) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AP1S1P619663, ENSP000003366664I2D: score=2 STRING: ENSP00000336666
    STK36Q9NRP73, ENSP000002957094I2D: score=2 STRING: ENSP00000295709
    WRAP73Q9P2S53, ENSP000002707084I2D: score=2 STRING: ENSP00000270708
    PSMD6Q150083, ENSP000002959014I2D: score=1 STRING: ENSP00000295901
    SAP18O004223, ENSP000003719734I2D: score=1 STRING: ENSP00000371973
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARMC6
    Search CenterWatch for drugs/clinical trials and news about ARMC6 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARMC6 gene (2 alternative transcripts): 
    NM_001199196.1  NM_033415.3  

    Unigene Cluster for ARMC6:

    Armadillo repeat containing 6
    Hs.77876  [show with all ESTs]
    Unigene Representative Sequence: NM_001199196
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000392335(uc002nlc.3) ENST00000535612(uc002nld.3 uc010xqm.2)
    ENST00000537263 ENST00000540707 ENST00000541725 ENST00000269932 ENST00000546344(uc010xql.2)
    ENST00000540792 ENST00000536098 ENST00000541898 ENST00000539985 ENST00000543877
    ENST00000545091 ENST00000535288 ENST00000545190 ENST00000538663 ENST00000392336
    ENST00000535758

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    Inhib. RNA
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    Additional cDNA sequence: 

    AK295488.1 AK303914.1 BC003700.1 BC056161.1 BC067125.1 BX648486.1 CR749678.1 Z36779.1 

    15 DOTS entries:

    DT.444151  DT.100812701  DT.91770965  DT.91770971  DT.95347755  DT.95327921  DT.100682839  DT.95347758 
    DT.121472250  DT.100812688  DT.97847966  DT.100812692  DT.86857160  DT.100812690  DT.100812695 

    24/317 AceView cDNA sequences (see all 317):

    BU624436 BU194051 BM021391 BM703787 CB150509 BQ045265 AI521751 BU849058 
    NM_033415 BI918170 BI966271 BQ229709 BG335225 BQ013126 BQ942317 H92780 
    CD672850 BM804237 BQ957756 AW235919 BQ012036 BU856340 CR610870 CB216136 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ARMC6 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a ·
    SP1:                                      -                 -     -                                                                                             
    SP2:                                      -                       -                                                                                             
    SP3:                                                        -                                                                                                   
    SP4:                                                                                                  -     -     -     -                                       
    SP5:                                      -     -     -     -     -                                                                                             

    ExUns: 12b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for ARMC6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARMC6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGGCCTCTG
    ARMC6 Expression
    About this image
    See ARMC6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARMC6

    SOURCE GeneReport for Unigene cluster: Hs.77876
        SABiosciences Custom PCR Arrays for ARMC6

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARMC6 gene from 7/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Armc61 , 5 armadillo repeat containing 61, 5 81.3(n)1
    83.94(a)1
      8 (34.15 cM)5
    768131  NM_133972.21  NP_598733.21 
     702201725 
    chicken
    (Gallus gallus)
    Aves ARMC61 armadillo repeat containing 6 67.37(n)
    65.4(a)
      420112  XM_001233054.2  XP_001233055.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.204872 Xenopus laevis transcribed sequence with weak similarity more 72.18(n)    CD360558.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5554251 armadillo repeat-containing protein 6-like 64.37(n)
    63.01(a)
      555425  XM_677924.5  XP_683016.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG57211 CG5721 46.59(n)
    34.67(a)
      37084  NM_137462.3  NP_611306.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G339451 armadillo/beta-catenin-like repeat-containing protein 39.04(n)
    28.54(a)
      829540  NM_119555.3  NP_567944.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g07612001 hypothetical protein 40.59(n)
    28.34(a)
      4330807  NM_001054730.1  NP_001048195.1 


    ENSEMBL Gene Tree for ARMC6 (if available)
    TreeFam Gene Tree for ARMC6 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/445 NCBI SNPs in ARMC6 are shown (see all 445    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1828399201,2
    --19146419(+) TCAGTC/TAGCTC 2 -- int10--------
    rs1889364771,2
    --19146505(+) AGGCAA/GCCACC 2 -- int10--------
    rs113768561,2
    C--19146575(+) CAATC-/AAGTTA 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs345351321,2
    C--19146576(+) AATCA-/AGTTAG 2 -- int10--------
    rs347504021,2
    C--19146577(+) ATCAAA/G/TTTAGA 2 -- int11NA 2
    rs621380921,2
    C--19146577(+) AATCAA/G/TTTAGA 2 -- int11NA 2
    rs2012844601,2
    --19146577(+) ATCAG-/TTTAGA 2 -- int10--------
    rs680148021,2
    C--19146578(+) AGTTAT/-GAAAG 2 -- int11Minor allele frequency- -:0.00NA 2
    rs1995330871,2
    --19146580(+) CAGTT-/AGAA  
            
    AGCTT
    2 -- int10--------
    rs730089281,2
    C--19146729(+) GGTCAC/TAGGTA 2 -- int12Minor allele frequency- T:0.07NA 122

    HapMap Linkage Disequilibrium report for ARMC6 (19144384 - 19170563 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ARMC6: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARMC6
    DNA2.0 Custom Variant and Variant Library Synthesis for ARMC6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ARMC6 for disorders           About GeneDecksing

    2 diseases for ARMC6:    About MalaCards
    pancreatic cancer    pancreatitis


    Export disorders for ARMC6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARMC6 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with ARMC6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 93436 HGNC: 25049 AceView: ARMC6 Ensembl:ENSG00000105676 euGenes: HUgn93436
    ECgene: ARMC6 H-InvDB: ARMC6

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for ARMC6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARMC6 gene:
    Search GeneIP for patents involving ARMC6

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