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Aliases for ARMC6 Gene

Aliases for ARMC6 Gene

  • Armadillo Repeat Containing 6 2 3 5
  • Armadillo Repeat-Containing Protein 6 3
  • R30923_1 3

External Ids for ARMC6 Gene

Previous GeneCards Identifiers for ARMC6 Gene

  • GC19P019144
  • GC19P018708

Summaries for ARMC6 Gene

Entrez Gene Summary for ARMC6 Gene

  • The function of this gene's protein product has not been determined. A related protein in mouse suggests that this protein has a conserved function. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for ARMC6 Gene

ARMC6 (Armadillo Repeat Containing 6) is a Protein Coding gene. GO annotations related to this gene include binding.

Gene Wiki entry for ARMC6 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARMC6 Gene

Genomics for ARMC6 Gene

Regulatory Elements for ARMC6 Gene

Enhancers for ARMC6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ARMC6 on UCSC Golden Path with GeneCards custom track

Promoters for ARMC6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ARMC6 Gene

19,033,575 bp from pter
19,060,311 bp from pter
26,737 bases
Plus strand

Genomic View for ARMC6 Gene

Genes around ARMC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARMC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARMC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARMC6 Gene

Proteins for ARMC6 Gene

  • Protein details for ARMC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Armadillo repeat-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • B4DI98
    • O94999
    • Q9BTH5

    Protein attributes for ARMC6 Gene

    501 amino acids
    Molecular mass:
    54142 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD03162.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAH67125.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARMC6 Gene


neXtProt entry for ARMC6 Gene

Post-translational modifications for ARMC6 Gene

  • Ubiquitination at Lys 125, Lys 134, Lys 208, Lys 274, Lys 284, Lys 345, Lys 361, Lys 422, Lys 432, and Lys 450
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARMC6 Gene

Domains & Families for ARMC6 Gene

Gene Families for ARMC6 Gene

Protein Domains for ARMC6 Gene

Suggested Antigen Peptide Sequences for ARMC6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ARMC6 family.
  • Contains 4 ARM repeats.
  • Belongs to the ARMC6 family.
  • Contains 4 ARM repeats.
genes like me logo Genes that share domains with ARMC6: view

Function for ARMC6 Gene

genes like me logo Genes that share phenotypes with ARMC6: view

Animal Model Products

CRISPR Products

miRNA for ARMC6 Gene

miRTarBase miRNAs that target ARMC6

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARMC6 Gene

Localization for ARMC6 Gene

Subcellular locations from

Jensen Localization Image for ARMC6 Gene COMPARTMENTS Subcellular localization image for ARMC6 gene
Compartment Confidence
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ARMC6 Gene

Pathways & Interactions for ARMC6 Gene

SuperPathways for ARMC6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARMC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
genes like me logo Genes that share ontologies with ARMC6: view

No data available for Pathways by source and SIGNOR curated interactions for ARMC6 Gene

Drugs & Compounds for ARMC6 Gene

No Compound Related Data Available

Transcripts for ARMC6 Gene

Unigene Clusters for ARMC6 Gene

Armadillo repeat containing 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARMC6 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a ·
SP1: - - -
SP2: - -
SP3: -
SP4: - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - -
SP8: -
SP9: - - - - - -

ExUns: 12b

Relevant External Links for ARMC6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARMC6 Gene

mRNA expression in normal human tissues for ARMC6 Gene

Protein differential expression in normal tissues from HIPED for ARMC6 Gene

This gene is overexpressed in Bone (56.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARMC6 Gene

Protein tissue co-expression partners for ARMC6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARMC6 Gene:


SOURCE GeneReport for Unigene cluster for ARMC6 Gene:

genes like me logo Genes that share expression patterns with ARMC6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARMC6 Gene

Orthologs for ARMC6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARMC6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARMC6 34
  • 85.11 (n)
  • 84.83 (a)
ARMC6 35
  • 84 (a)
(Canis familiaris)
Mammalia ARMC6 34
  • 84.01 (n)
  • 85.29 (a)
ARMC6 35
  • 84 (a)
(Mus musculus)
Mammalia Armc6 34
  • 81.3 (n)
  • 83.94 (a)
Armc6 16
Armc6 35
  • 83 (a)
(Pan troglodytes)
Mammalia ARMC6 34
  • 98.8 (n)
  • 98.8 (a)
ARMC6 35
  • 99 (a)
(Rattus norvegicus)
Mammalia Armc6 34
  • 80.57 (n)
  • 79.92 (a)
(Monodelphis domestica)
Mammalia ARMC6 35
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia ARMC6 35
  • 65 (a)
(Gallus gallus)
Aves ARMC6 34
  • 67.37 (n)
  • 65.4 (a)
ARMC6 35
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia armc6 34
  • 62.72 (n)
  • 66.67 (a)
Str.9830 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.20487 34
(Danio rerio)
Actinopterygii LOC555425 34
  • 64.52 (n)
  • 63.44 (a)
ARMC6 35
  • 57 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006617 34
  • 47.74 (n)
  • 33.63 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5721 34
  • 47.11 (n)
  • 34.89 (a)
CG5721 35
  • 32 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G33945 34
  • 39.53 (n)
  • 29.02 (a)
(Oryza sativa)
Liliopsida Os02g0761200 34
  • 40.67 (n)
  • 29.25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3480 35
  • 32 (a)
Species where no ortholog for ARMC6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARMC6 Gene

Gene Tree for ARMC6 (if available)
Gene Tree for ARMC6 (if available)

Paralogs for ARMC6 Gene

genes like me logo Genes that share paralogs with ARMC6: view

No data available for Paralogs for ARMC6 Gene

Variants for ARMC6 Gene

Sequence variations from dbSNP and Humsavar for ARMC6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3180531 -- 19,058,172(+) GTGAA(A/C)AGCGG utr-variant-3-prime
rs3209855 -- 19,051,772(+) CTGCC(A/T)GGAAG reference, missense
rs3214143 -- 19,042,992(+) AGGTG(-/C)CCATT intron-variant
rs3746260 -- 19,055,514(-) GCCCA(C/T)GACCC intron-variant, downstream-variant-500B
rs10661975 -- 19,046,942(+) TTTTT(-/TT/TTC/TTTC/TTTT)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARMC6 Gene

Variant ID Type Subtype PubMed ID
nsv1059305 CNV loss 25217958
nsv1151217 CNV deletion 26484159
nsv833778 CNV loss 17160897
nsv833779 CNV loss 17160897
nsv952424 CNV deletion 24416366

Variation tolerance for ARMC6 Gene

Residual Variation Intolerance Score: 48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.80; 33.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARMC6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARMC6 Gene

Disorders for ARMC6 Gene

Relevant External Links for ARMC6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARMC6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARMC6 Gene

Publications for ARMC6 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  4. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3 65
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 65

Products for ARMC6 Gene

Sources for ARMC6 Gene

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