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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARMC5 Gene

protein-coding   GIFtS: 42
GCID: GC16P031473

Armadillo Repeat Containing 5

  Search for ARMC5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Armadillo Repeat Containing 51 2
Armadillo Repeat-Containing Protein 52

External Ids:    HGNC: 257811   Entrez Gene: 797982   Ensembl: ENSG000001406917   UniProtKB: Q96C123   

Export aliases for ARMC5 gene to outside databases

Previous GC identifers: GC16P031507 GC16P031377 GC16P029030


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ARMC5 Gene: 
ARMC5 (armadillo repeat containing 5) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARMC5 gene promoter:
         COUP-TF1   COUP-TF   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ARMC5 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARMC5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARMC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11

ARMC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARMC5 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P031473:  view genomic region     (about GC identifiers)

Start:
31,469,401 bp from pter      End:
31,478,488 bp from pter
Size:
9,088 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARMC5_HUMAN, Q96C12 (See protein sequence)
Recommended Name: Armadillo repeat-containing protein 5  
Size: 935 amino acids; 97682 Da
Sequence caution: Sequence=BAB15720.1; Type=Erroneous initiation;
Secondary accessions: Q86WM9 Q9H7P8 Q9H925
Alternative splicing: 4 isoforms:  Q96C12-1   Q96C12-2   Q96C12-3   Q96C12-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARMC5: NX_Q96C12

Explore proteomics data for ARMC5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96C12

  • ARMC5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARMC5 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001098717.1  NP_079018.1  

    ENSEMBL proteins: 
     ENSP00000386125   ENSP00000399561   ENSP00000456877   ENSP00000456571   ENSP00000454430  
     ENSP00000443995   ENSP00000268314   ENSP00000400183  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ARMC: Armadillo repeat containing

    5 InterPro protein domains:
     IPR011333 BTB/POZ_fold
     IPR011989 ARM-like
     IPR000225 Armadillo
     IPR016024 ARM-type_fold
     IPR000210 BTB/POZ-like

    Graphical View of Domain Structure for InterPro Entry Q96C12

    ProtoNet protein and cluster: Q96C12

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: ARMC5_HUMAN, Q96C12
    Similarity: Contains 7 ARM repeats
    Similarity: Contains 1 BTB (POZ) domain


    ARMC5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
         
    ARMC5 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARMC5

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ARMC5 (ENSP000002683144) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARMC5

    Search CenterWatch for drugs/clinical trials and news about ARMC5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARMC5 gene (2 alternative transcripts): 
    NM_001105247.1  NM_024742.2  

    Unigene Cluster for ARMC5:

    Armadillo repeat containing 5
    Hs.732945  [show with all ESTs]
    Unigene Representative Sequence: NM_024742
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000408912(uc010vfn.2) ENST00000457010(uc002ecb.2 uc010vfo.2 uc002ecc.3 uc002eca.4 uc010vfp.2)
    ENST00000563544 ENST00000564900 ENST00000564514 ENST00000570119 ENST00000538189
    ENST00000268314 ENST00000412665
    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate ARMC5:
    hsa-miR-1237 hsa-miR-767-3p hsa-miR-216a
    SwitchGear 3'UTR luciferase reporter plasmidARMC5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARMC5
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    GenScript: all cDNA clones in your preferred vector (see all 2): ARMC5 (NM_024742)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARMC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARMC5
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                         Customized lentivirus expression plasmids for stable overexpression of ARMC5 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARMC5

    Additional mRNA sequence: 

    AK023125.1 AK024430.1 AK294897.1 AK295790.1 AK297115.1 AY217348.1 BC014945.1 

    6 DOTS entries:

    DT.101047  DT.100813679  DT.100813677  DT.95265857  DT.120681368  DT.95176214 

    24/63 AceView cDNA sequences (see all 63):

    CK823492 BE794733 AY217348 NM_024742 BQ054371 CB155857 AI268225 BF476125 
    AK024430 BQ052601 BM967236 BQ006285 AK023125 BC014945 AA777368 AI400328 
    BM893922 BE889346 BU556955 BG393524 CD722223 AW007764 BM981201 BU615458 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ARMC5    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
    SP1:                    -                                               -               
    SP2:                    -                                                               
    SP3:                                            -     -                                 
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for ARMC5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARMC5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAACCGGACT
    ARMC5 Expression
    About this image


    See ARMC5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARMC5

    SOURCE GeneReport for Unigene cluster: Hs.732945
        SABiosciences Custom PCR Arrays for ARMC5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARMC5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ARMC5 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Armc51 , 5 armadillo repeat containing 51, 5 83.59(n)1
    87.34(a)1
      7 (70.06 cM)5
    2339121  NM_146205.21  NP_666317.21 
     1282373575 
    lizard
    (Anolis carolinensis)
    Reptilia ARMC56
    Uncharacterized protein
    50(a)
    1 ↔ 1
    GL343220.1(2513462-2522948)
    zebrafish
    (Danio rerio)
    Actinopterygii armc51 armadillo repeat containing 5 49.24(n)
    42.49(a)
      569910  XM_693324.4  XP_698416.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG78376
    --
    18(a)
    1 ↔ 1
    3R(25621419-25625055)


    ENSEMBL Gene Tree for ARMC5 (if available)
    TreeFam Gene Tree for ARMC5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/333 SNPs in ARMC5 are shown (see all 333)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1385522521,2
    --29028550(+) AAGGCA/CGGGGA 2 -- us2k10--------
    rs285330311,2
    C,F,H--31468438(+) AGGTTA/CGGAAT 2 -- us2k17Minor allele frequency- C:0.12NS NA CSA WA 910
    rs1825377791,2
    --31468439(+) GGTTAA/GGAATG 2 -- us2k10--------
    rs1873043711,2
    --31468603(+) AGGCAA/GCTGGG 2 -- us2k10--------
    rs1167306081,2
    C--31468691(+) CAAACC/GTAAGC 2 -- us2k10--------
    rs1917014531,2
    --31468767(+) TGGGGC/TTCCTT 2 -- us2k10--------
    rs1489104721,2
    --31468793(+) TTAAA-/TTTGTTA 2 -- us2k10--------
    rs1831090371,2
    --31468945(+) CGCCTA/GGCATT 2 -- us2k10--------
    rs1873986561,2
    --31468958(+) TTTTTA/TAGTAG 2 -- us2k10--------
    rs1925461151,2
    --31469022(+) GATCCA/GCTAAC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARMC5 (31469401 - 31478488 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ARMC5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833194CNV Loss17160897
    dgv2673n71CNV Loss21882294
    nsv905751CNV Loss21882294
    nsv905747CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARMC5 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ARMC5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    3. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    4. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    5. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    6. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    10. Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)1 Hattori A.... Ohara O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79798 HGNC: 25781 AceView: ARMC5 Ensembl:ENSG00000140691 euGenes: HUgn79798
    ECgene: ARMC5 H-InvDB: ARMC5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARMC5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARMC5 gene:
    Search GeneIP for patents involving ARMC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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