ARMC5 Gene
protein-coding GIFtS: 40
GCID: GC16P031473
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|
armadillo repeat containing 5
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Aliases
for ARMC5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Armadillo Repeat Containing 51 2 | | FLJ130631 | | Armadillo Repeat-Containing Protein 52 |
Export aliases for ARMC5 gene to outside databasesPrevious GC identifers: GC16P031507 GC16P031377 GC16P029030 |
Summaries
for ARMC5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ARMC5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ARMC5 gene promoter:
COUP-TF1 COUP-TF COUP HNF-4alpha2 HNF-4alpha1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARMC5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARMC5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11ARMC5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P031473: view genomic region
(about GC identifiers)
Start:
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31,469,401 bp from pter |
End:
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31,478,488 bp from pter |
Size:
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9,088 bases |
Orientation:
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plus strand |
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Proteins
for ARMC5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ARMC5_HUMAN, Q96C12 (See
protein sequence)Recommended Name: Armadillo repeat-containing protein 5 Size: 935 amino acids; 97682 Da
Sequence caution: Sequence=BAB15720.1; Type=Erroneous initiation;
Secondary accessions: Q86WM9 Q9H7P8 Q9H925Alternative splicing: 4 isoforms: Q96C12-1 Q96C12-2 Q96C12-3 Q96C12-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ARMC5: NX_Q96C12
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96C12
ARMC5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001098717.1 NP_079018.1
ENSEMBL proteins: ENSP00000386125 ENSP00000399561 ENSP00000456877 ENSP00000456571 ENSP00000454430 ENSP00000443995 ENSP00000268314 ENSP00000400183
Human Recombinant Protein Products:
ARMC5 Antibody Products:
Assay Products for ARMC5: |
Protein
Domains /
Families
for ARMC5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARMC5 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96C12ProtoNet protein and cluster: Q96C12 1 Blocks protein family: IPB000210 BTB/POZ domain
UniProtKB/Swiss-Prot: ARMC5_HUMAN, Q96C12Similarity: Contains 7 ARM repeatsSimilarity: Contains 1 BTB (POZ) domain |
Function
for ARMC5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARMC5 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARMC5 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ARMC5 (NM_024742) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARMC5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARMC5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARMC5 |
|
Pathways & Interactions
for ARMC5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARMC5
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ARMC5 (ENSP000002683144) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for ARMC5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ARMC5
Search CenterWatch for drugs/clinical trials and news about ARMC5
|
Transcripts
for ARMC5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ARMC5 gene (2 alternative transcripts): NM_001105247.1 NM_024742.2 Unigene Cluster for ARMC5: Armadillo repeat containing 5 Hs.732945 [show with all ESTs]Unigene Representative Sequence: NM_0247429 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000408912(uc010vfn.2) ENST00000457010(uc002ecb.2 uc010vfo.2 uc002ecc.3 uc002eca.4 uc010vfp.2)
ENST00000563544 ENST00000564900 ENST00000564514 ENST00000570119 ENST00000538189
ENST00000268314 ENST00000412665
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARMC5 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARMC5 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ARMC5 (NM_024742) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARMC5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARMC5 |
Additional cDNA sequence: AK023125.1 AK024430.1 AK294897.1 AK295790.1 AK297115.1 AY217348.1 BC014945.1 6 DOTS entries: DT.101047 DT.100813679 DT.100813677 DT.95265857 DT.120681368 DT.95176214 24/63 AceView cDNA sequences (see all 63): BM967236 AK023125 BQ006285 BE794733 BQ054371 AA777368 AY217348 BC014945 AI400328 BF476125 CB155857 BQ052601 CK823492 NM_024742 AK024430 AI268225 BU615458 BG393524 AU130928 CF125621 BI522787 BU556955 BQ332313 BF315879
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ARMC5 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c |
|---|
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| SP1: | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ARMC5
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Expression
for ARMC5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARMC5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAACCGGACT
About this image
See ARMC5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARMC5
SOURCE GeneReport for Unigene cluster: Hs.732945
SABiosciences Custom PCR Arrays for ARMC5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARMC5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARMC5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARMC5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARMC5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARMC5 |
Orthologs
for ARMC5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ARMC5 gene from 4/14 species (see all 14) About this table
ENSEMBL Gene Tree for ARMC5 (if available)
TreeFam Gene Tree for ARMC5 (if available) |
Paralogs
for ARMC5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ARMC5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ARMC5 (31469401 - 31478488 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ARMC5: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARMC5 |
|
Disorders
/ Diseases
for ARMC5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ARMC5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARMC5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ARMC5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)1 Hattori A.... Ohara O. (2000)
|
External Searches for ARMC5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ARMC5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ARMC5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ARMC5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ARMC5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ARMC5 gene:
Search GeneIP for patents involving ARMC5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ARMC5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ARMC5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARMC5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARMC5 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ARMC5 | | OriGene 3'-UTR Clone for ARMC5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARMC5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARMC5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ARMC5 | | OriGene Custom Protein Services for ARMC5 | | | OriGene Custom Immunoassay Development | | |
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 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARMC5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARMC5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARMC5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARMC5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARMC5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARMC5 |
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| | | | Search Tocris compounds for ARMC5 |
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 | | | ARMC5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARMC5 |
|  |  |  | | | | ThermoFisher Antibody for ARMC5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARMC5 |
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