ARMC3 Gene
protein-coding GIFtS : 45
GCID: GC10 P023256
armadillo repeat containing 3
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Aliasesfor ARMC3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Armadillo Repeat Containing 3 1 2 KU-CT-12 3 CT811 2 3 FLJ328271 Beta-Catenin-Like Protein2 3 Armadillo Repeat-Containing Protein 32 Cancer/Testis Antigen 812 3
Export aliases for ARMC3 gene to outside databases Previous GC identifers: GC00U913740 GC10P023221 GC10P022877
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Summariesfor ARMC3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ARMC3 : Armadillo/beta-catenin (CTNNB1; MIM 116806)-like (ARM) domains are imperfect 45-amino acid repeats involved in protein-protein interactions. ARM domain-containing proteins, such as ARMC3, function in signal transduction, development, cell adhesion and mobility, and tumor initiation and metastasis (Li et al., 2006 (PubMed 16915934)).(supplied by OMIM, Mar 2008)
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Genomic Viewsfor ARMC3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000010.10 NC_018921.1 NT_008705.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ARMC3 gene promoter: AML1a HNF-1A C/EBPalpha GATA-1 MEF-2A Ik-2 FOXJ2 (long isoform) HNF-1 aMEF-2 FOXJ2 Other transcription factors Search SABiosciences Chromatin IP Primers for ARMC3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARMC3
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 10p12.31 Ensembl cytogenetic band: 10p12.2 HGNC cytogenetic band: 10p12.31 ARMC3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 10 GeneLoc Exon Structure
GeneLoc location for GC10P023256: view genomic region
(about GC identifiers )
Start:
23,216,953 bp from pter
End:
23,326,518 bp from pter
Size:
109,566 bases
Orientation:
plus strand
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Proteinsfor ARMC3 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ARMC3_HUMAN, Q5W041 (See
protein sequence )Recommended Name: Armadillo repeat-containing protein 3 Size : 872 amino acids; 96405 Da
Sequence caution : Sequence=BAC05389.1; Type=Erroneous initiation;
Secondary accessions : A0PG76 A6NH64 B4DZL3 B7ZBN6 B7ZBN7 Q8IXS5 Q8N7B0 Q96M49Alternative splicing : 4 isoforms : Q5W041-2 Q5W041-3 Q5W041-4 Q5W041-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ARMC3: NX_Q5W041 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q5W041 ARMC3 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_775104.2 ENSEMBL proteins: ENSP00000298032 ENSP00000386943 ENSP00000365706 ENSP00000387288 ENSP00000396629 ENSP00000365711 Human Recombinant Protein Products: ARMC3 Antibody Products: Assay Products for ARMC3:
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Protein
Domains / Familiesfor ARMC3 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ARMC3 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q5W041 ProtoNet protein and cluster: Q5W041
1 Blocks protein family : IPB000225 Armadillo repeat UniProtKB/Swiss-Prot: ARMC3_HUMAN, Q5W041 Similarity : Contains 12 ARM repeats
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Functionfor ARMC3 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ARMC3 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ARMC3OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ARMC3 (NM_173081 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARMC3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ARMC3
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARMC3
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Pathways & Interactionsfor ARMC3 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARMC3 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)2 Interacting proteins for ARMC3 (ENSP00000298032 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor ARMC3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for ARMC3 Search CenterWatch for drugs/clinical trials and news about ARMC3
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Transcriptsfor ARMC3 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ARMC3 gene: NM_173081.3 Unigene Cluster for ARMC3:
Armadillo repeat containing 3 Hs.659807 [show with all ESTs ] Unigene Representative Sequence: NM_173081 14 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000298032 (uc001irm.4 uc010qcv.2 uc010qcw.2 ) ENST00000409983 ENST00000376523 ENST00000409049 ENST00000484642 ENST00000496741 ENST00000447081 ENST00000468003 ENST00000483596 ENST00000465729 ENST00000464017 (uc001irn.1 )ENST00000491803 ENST00000473919 ENST00000376528 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ARMC3 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ARMC3OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ARMC3 (NM_173081 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARMC3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ARMC3
Additional cDNA sequence: AK057389.1 AK090961.1 AK098711.1 AK302104.1 AK302985.1 AY436643.1 BC039312.1 DQ525422.1
8 DOTS entries : DT.40205056 DT.40122502
DT.99930775 DT.100745260 DT.100661077 DT.65287466 DT.95106967 DT.40304950 24/44 AceView cDNA sequences (see all 44 ):
BQ027437 AI920819 AW470041 AK098711 BC039312 BE043122 AW169364 AK057389 NM_173081 AI936559 AI628706 BG717245 BI767641 BU853516 AI313263 BG718829 BU568065 CA313097 AA383466 BG723884 AK090961 AI683856 BM976493 BG539428 GeneLoc Exon Structure 5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ARMC3 (see all 9 ) About this scheme ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ SP1 :       -   -         -   -   -                                 SP2 :       -   -         -   -   -                                 SP3 :     -   -   -   -         -     -           -   -                   SP4 :       -   -         -   -   -   -   -                             SP5 :       -   -         -   -   -   -   -   -   -   -                      
ExUns: 21 ^ 22 SP1 :     SP2 :     SP3 :     SP4 :     SP5 :    
ECgene alternative splicing isoforms for ARMC3
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Expression for ARMC3 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ARMC3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image ARMC3 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See ARMC3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ARMC3 SOURCE GeneReport for Unigene cluster: Hs.659807 UniProtKB/Swiss-Prot: ARMC3_HUMAN, Q5W041 Tissue specificity : Isoform 2 is expressed in skeletal muscle, brain, lung, kidney, prostate and testis. Isoform 3 ismainly expressed in skeletal muscle, liver, spleen and thymus. Expressed in many cancer tissues and cell lines SABiosciences Custom PCR Arrays for ARMC3 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ARMC3Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ARMC3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ARMC3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ARMC3 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARMC3
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Orthologsfor ARMC3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for ARMC3 gene from 7/25 species (see all 25 ) About this table
ENSEMBL Gene Tree for ARMC3 (if available)TreeFam Gene Tree for ARMC3 (if available)
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Paralogsfor ARMC3 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ARMC3 gene CTNNB1 2 JUP 2 ARMC4 2
ARMC3 for paralogs About GeneDecksing
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Genomic Variantsfor ARMC3 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 10 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ARMC3 (23216953 - 23326518 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ARMC3: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ARMC3
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Disorders
/ Diseasesfor ARMC3 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ARMC3 for disorders About GeneDecksing
OMIM gene information: 611226
OMIM disorders : --4 diseases for ARMC3 : About MalaCards endometrial cancer alzheimer's disease pancreatitis prostatitis Human Genome Epidemiology (HuGE) Navigator: ARMC3 (2 documents) Export disorders for ARMC3 gene to outside databases
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Publicationsfor ARMC3 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ARMC3 gene integrated from 9 sources : (articles sorted by number of sources associating them with ARMC3) Utopia : connect your pdf to the dynamic world of online information
Cloning and expression of ARMC3_v2, a novel splicing variant of the human ARMC3 gene. (PubMed id 16915934) 1 , 2 Li X.... Mao Y. (2006) A novel cancer testis antigen that is frequently expressed in pancreatic, lung, and endometrial cancers. (PubMed id 16397042) 1 , 2 Okada T.... Kawakami Y. (2006) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451) 1 Grupe A....Goate A. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054) 2 Deloukas P.... Rogers J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for ARMC3 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ARMC3 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ARMC3 gene
(According to HUGE )
About This Section --
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Specialized Databases showing ARMC3 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ARMC3 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ARMC3 gene: Search GeneIP for patents involving ARMC3 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ARMC3 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for ARMC3 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ARMC3 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ARMC3 OriGene Protein Over-expression Lysate for ARMC3 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ARMC3 OriGene 3'-UTR Clone for ARMC3 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ARMC3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ARMC3 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for ARMC3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ARMC3 OriGene Custom Protein Services for ARMC3 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARMC3 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ARMC3 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARMC3 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ARMC3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ARMC3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ARMC3
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ARMC3 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARMC3
ThermoFisher Antibodies for ARMC3
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ARMC3
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Aliases for ARMC3
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Disorders / Diseases for ARMC3
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Expression for ARMC3
Function for ARMC3
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