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Aliases for ARMC3 Gene

Aliases for ARMC3 Gene

  • Armadillo Repeat Containing 3 2 3 5
  • Cancer/Testis Antigen 81 2 3 4
  • Beta-Catenin-Like Protein 3 4
  • KU-CT-1 3 4
  • CT81 3 4

External Ids for ARMC3 Gene

Previous GeneCards Identifiers for ARMC3 Gene

  • GC00U913740
  • GC10P023221
  • GC10P023256

Summaries for ARMC3 Gene

Entrez Gene Summary for ARMC3 Gene

  • Armadillo/beta-catenin (CTNNB1; MIM 116806)-like (ARM) domains are imperfect 45-amino acid repeats involved in protein-protein interactions. ARM domain-containing proteins, such as ARMC3, function in signal transduction, development, cell adhesion and mobility, and tumor initiation and metastasis (Li et al., 2006 [PubMed 16915934]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARMC3 Gene

ARMC3 (Armadillo Repeat Containing 3) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is ARMC4.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARMC3 Gene

Genomics for ARMC3 Gene

Regulatory Elements for ARMC3 Gene

Promoters for ARMC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARMC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARMC3 Gene

Chromosome:
10
Start:
22,928,024 bp from pter
End:
23,038,523 bp from pter
Size:
110,500 bases
Orientation:
Plus strand

Genomic View for ARMC3 Gene

Genes around ARMC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARMC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARMC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARMC3 Gene

Proteins for ARMC3 Gene

  • Protein details for ARMC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5W041-ARMC3_HUMAN
    Recommended name:
    Armadillo repeat-containing protein 3
    Protein Accession:
    Q5W041
    Secondary Accessions:
    • A0PG76
    • A6NH64
    • B4DZL3
    • B7ZBN6
    • B7ZBN7
    • Q8IXS5
    • Q8N7B0
    • Q96M49

    Protein attributes for ARMC3 Gene

    Size:
    872 amino acids
    Molecular mass:
    96405 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05389.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ARMC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARMC3 Gene

Proteomics data for ARMC3 Gene at MOPED

Post-translational modifications for ARMC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ARMC3

No data available for DME Specific Peptides for ARMC3 Gene

Domains & Families for ARMC3 Gene

Gene Families for ARMC3 Gene

Protein Domains for ARMC3 Gene

Suggested Antigen Peptide Sequences for ARMC3 Gene

Graphical View of Domain Structure for InterPro Entry

Q5W041

UniProtKB/Swiss-Prot:

ARMC3_HUMAN :
  • Contains 12 ARM repeats.
Similarity:
  • Contains 12 ARM repeats.
genes like me logo Genes that share domains with ARMC3: view

Function for ARMC3 Gene

Phenotypes for ARMC3 Gene

GenomeRNAi human phenotypes for ARMC3:
genes like me logo Genes that share phenotypes with ARMC3: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ARMC3 Gene

Localization for ARMC3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARMC3 Gene COMPARTMENTS Subcellular localization image for ARMC3 gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for ARMC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with ARMC3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARMC3 Gene

Pathways & Interactions for ARMC3 Gene

SuperPathways for ARMC3 Gene

No Data Available

Interacting Proteins for ARMC3 Gene

Gene Ontology (GO) - Biological Process for ARMC3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ARMC3 Gene

Drugs & Compounds for ARMC3 Gene

No Compound Related Data Available

Transcripts for ARMC3 Gene

Unigene Clusters for ARMC3 Gene

Armadillo repeat containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARMC3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - -
SP7:
SP8:
SP9:

ExUns: 21 ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ARMC3 Gene

GeneLoc Exon Structure for
ARMC3
ECgene alternative splicing isoforms for
ARMC3

Expression for ARMC3 Gene

mRNA expression in normal human tissues for ARMC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARMC3 Gene

This gene is overexpressed in Testis (x21.5), Brain - Hypothalamus (x4.1), and Brain - Caudate (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for ARMC3 Gene

This gene is overexpressed in Blymphocyte (36.4) and Testis (20.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARMC3 Gene



SOURCE GeneReport for Unigene cluster for ARMC3 Gene Hs.659807

mRNA Expression by UniProt/SwissProt for ARMC3 Gene

Q5W041-ARMC3_HUMAN
Tissue specificity: Isoform 1 is expressed in skeletal muscle, brain, lung, kidney, prostate and testis. Isoform 3 is mainly expressed in skeletal muscle, liver, spleen and thymus. Expressed in many cancer tissues and cell lines.
genes like me logo Genes that share expression patterns with ARMC3: view

Protein tissue co-expression partners for ARMC3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for ARMC3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARMC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARMC3 35
  • 98.28 (n)
  • 97.72 (a)
ARMC3 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARMC3 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARMC3 36
  • 86 (a)
OneToOne
ARMC3 35
  • 87.32 (n)
  • 86.71 (a)
mouse
(Mus musculus)
Mammalia Armc3 16
Armc3 35
  • 79.64 (n)
  • 82.62 (a)
Armc3 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARMC3 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARMC3 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Armc3 35
  • 80.19 (n)
  • 84.82 (a)
chicken
(Gallus gallus)
Aves ARMC3 35
  • 69.92 (n)
  • 65.42 (a)
ARMC3 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARMC3 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia armc3 35
  • 64.12 (n)
  • 61.97 (a)
zebrafish
(Danio rerio)
Actinopterygii BX469922.1 36
  • 49 (a)
OneToOne
armc3 35
  • 55.5 (n)
  • 51.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5155 36
  • 14 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VAC8 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.852 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToOne
Species with no ortholog for ARMC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARMC3 Gene

ENSEMBL:
Gene Tree for ARMC3 (if available)
TreeFam:
Gene Tree for ARMC3 (if available)

Paralogs for ARMC3 Gene

Paralogs for ARMC3 Gene

genes like me logo Genes that share paralogs with ARMC3: view

Variants for ARMC3 Gene

Sequence variations from dbSNP and Humsavar for ARMC3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_050669 -
rs11013233 - 23,006,974(+) GTAAA(C/T)CTTAC reference, missense
rs10828395 - 23,008,323(+) TGGAC(A/G)AAGTA reference, missense
rs899376 -- 23,032,018(+) AGGCC(A/G)AGATG intron-variant
rs1148299 -- 22,942,345(-) AGAAT(A/C)CATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARMC3 Gene

Variant ID Type Subtype PubMed ID
esv2734006 CNV Deletion 23290073
esv2662526 CNV Deletion 23128226

Variation tolerance for ARMC3 Gene

Residual Variation Intolerance Score: 76.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.89; 87.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARMC3 Gene

HapMap Linkage Disequilibrium report
ARMC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARMC3 Gene

Disorders for ARMC3 Gene

Relevant External Links for ARMC3

Genetic Association Database (GAD)
ARMC3
Human Genome Epidemiology (HuGE) Navigator
ARMC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARMC3

No disorders were found for ARMC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARMC3 Gene

Publications for ARMC3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 3
  3. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3
  5. Cloning and expression of ARMC3_v2, a novel splicing variant of the human ARMC3 gene. (PMID: 16915934) Li X. … Mao Y. (Genetika 2006) 3

Products for ARMC3 Gene

Sources for ARMC3 Gene

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