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Aliases for ARMC2 Gene

Aliases for ARMC2 Gene

  • Armadillo Repeat Containing 2 2 3 5
  • Armadillo Repeat-Containing Protein 2 3
  • BA787I22.1 3

External Ids for ARMC2 Gene

Previous GeneCards Identifiers for ARMC2 Gene

  • GC06P109215
  • GC06P109276
  • GC06P106736
  • GC06P109169

Summaries for ARMC2 Gene

GeneCards Summary for ARMC2 Gene

ARMC2 (Armadillo Repeat Containing 2) is a Protein Coding gene. GO annotations related to this gene include binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARMC2 Gene

Genomics for ARMC2 Gene

Regulatory Elements for ARMC2 Gene

Enhancers for ARMC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F108871 1.4 FANTOM5 Ensembl ENCODE 26.7 +25.4 25387 4.4 SOX13 TFAP4 TBL1XR1 SAP130 TEAD4 ASH2L BMI1 RAD21 ZIC2 CBX5 ARMC2 RNU6-653P ARMC2-AS1 ZBTB24 SESN1 RPS12P13 ATP5J2P2
GH06F108895 1.4 FANTOM5 Ensembl ENCODE 26.6 +48.2 48157 2.9 ZNF76 KLF17 RAD21 ZEB1 YY1 FOS KLF7 ZNF280D SP3 YY2 ARMC2 RNU6-653P ARMC2-AS1 OSTM1-AS1 FOXO3 CD164 ATP5J2P2 RPS12P13
GH06F108900 1.1 Ensembl ENCODE 24.7 +55.1 55148 6.7 PKNOX1 ATF1 CBX3 TBL1XR1 ZNF133 GATA4 RCOR1 CREM MIXL1 HMG20B ARMC2 ARMC2-AS1 RNU6-653P ATP5J2P2 RPS12P13
GH06F108781 1.2 Ensembl ENCODE 15 -66.1 -66113 2.2 ATF1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 ZNF121 ZNF143 KLF7 FOS ARMC2 ARMC2-AS1 CCDC162P ZNF259P1 LINC00222
GH06F108920 1 Ensembl ENCODE 13.9 +72.9 72887 2.2 PKNOX1 CREB3L1 CEBPG ZNF316 POLR2A FOXK2 NFIA L3MBTL2 CEBPB ZEB2 ARMC2 ARMC2-AS1 ENSG00000228834
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARMC2 on UCSC Golden Path with GeneCards custom track

Promoters for ARMC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001224058 186 1601 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF2 SLC30A9 GLIS2 SP3 MXD4

Genomic Location for ARMC2 Gene

Chromosome:
6
Start:
108,848,414 bp from pter
End:
108,998,506 bp from pter
Size:
150,093 bases
Orientation:
Plus strand

Genomic View for ARMC2 Gene

Genes around ARMC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARMC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARMC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARMC2 Gene

Proteins for ARMC2 Gene

  • Protein details for ARMC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEN0-ARMC2_HUMAN
    Recommended name:
    Armadillo repeat-containing protein 2
    Protein Accession:
    Q8NEN0
    Secondary Accessions:
    • A8K8Y4
    • B4DGF5
    • G5E993
    • Q5VVY8
    • Q9H0K9

    Protein attributes for ARMC2 Gene

    Size:
    867 amino acids
    Molecular mass:
    96867 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH30603.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAF85188.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI16717.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ARMC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARMC2 Gene

Post-translational modifications for ARMC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARMC2 Gene

Domains & Families for ARMC2 Gene

Gene Families for ARMC2 Gene

Protein Domains for ARMC2 Gene

Suggested Antigen Peptide Sequences for ARMC2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NEN0

UniProtKB/Swiss-Prot:

ARMC2_HUMAN :
  • Contains 12 ARM repeats.
Similarity:
  • Contains 12 ARM repeats.
genes like me logo Genes that share domains with ARMC2: view

Function for ARMC2 Gene

Gene Ontology (GO) - Molecular Function for ARMC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24407287
genes like me logo Genes that share ontologies with ARMC2: view
genes like me logo Genes that share phenotypes with ARMC2: view

Animal Model Products

miRNA for ARMC2 Gene

miRTarBase miRNAs that target ARMC2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARMC2 Gene

Localization for ARMC2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARMC2 gene
Compartment Confidence
nucleus 2
cytosol 2
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ARMC2 Gene

Pathways & Interactions for ARMC2 Gene

SuperPathways for ARMC2 Gene

No Data Available

Interacting Proteins for ARMC2 Gene

Selected Interacting proteins: Q8NEN0-ARMC2_HUMAN for ARMC2 Gene via IID

Symbol External ID(s) Details
IGHG1
PYCARD

Gene Ontology (GO) - Biological Process for ARMC2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ARMC2 Gene

Transcripts for ARMC2 Gene

Unigene Clusters for ARMC2 Gene

Armadillo repeat containing 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARMC2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
SP1: - - - - -
SP2: - - - - -
SP3: -
SP4: - - -
SP5: - - -
SP6: - - - - - - -
SP7: - - - - - -
SP8:

ExUns: 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for ARMC2 Gene

GeneLoc Exon Structure for
ARMC2
ECgene alternative splicing isoforms for
ARMC2

Expression for ARMC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARMC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARMC2 Gene

This gene is overexpressed in Testis (x5.4).

Protein differential expression in normal tissues from HIPED for ARMC2 Gene

This gene is overexpressed in Plasma (46.9) and Serum (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARMC2 Gene



Protein tissue co-expression partners for ARMC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARMC2 Gene:

ARMC2

SOURCE GeneReport for Unigene cluster for ARMC2 Gene:

Hs.645481
genes like me logo Genes that share expression patterns with ARMC2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ARMC2 Gene

Orthologs for ARMC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARMC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARMC2 34 35
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia ARMC2 34 35
  • 88.47 (n)
cow
(Bos Taurus)
Mammalia ARMC2 34 35
  • 87.17 (n)
mouse
(Mus musculus)
Mammalia Armc2 34 16 35
  • 77.4 (n)
rat
(Rattus norvegicus)
Mammalia Armc2 34
  • 76.92 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 76 (a)
OneToMany
-- 35
  • 76 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ARMC2 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARMC2 34 35
  • 65.93 (n)
lizard
(Anolis carolinensis)
Reptilia ARMC2 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia armc2 34
  • 60.55 (n)
zebrafish
(Danio rerio)
Actinopterygii armc2 34 35
  • 53.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32668 35
  • 24 (a)
OneToOne
Species where no ortholog for ARMC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARMC2 Gene

ENSEMBL:
Gene Tree for ARMC2 (if available)
TreeFam:
Gene Tree for ARMC2 (if available)

Paralogs for ARMC2 Gene

No data available for Paralogs for ARMC2 Gene

Variants for ARMC2 Gene

Sequence variations from dbSNP and Humsavar for ARMC2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1040848 -- 108,926,104(-) TCCCC(A/T)CATCT intron-variant
rs1040849 -- 108,921,883(-) GCAAT(C/T)ATCTG intron-variant
rs10456861 -- 108,861,967(+) TTGGG(C/T)TAAGA intron-variant
rs10456862 -- 108,977,886(+) ttctc(G/T)ttatt intron-variant
rs10456863 -- 108,977,889(+) tcttt(A/T)ttctt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARMC2 Gene

Variant ID Type Subtype PubMed ID
esv2656715 CNV deletion 23128226
esv2673947 CNV deletion 23128226
esv3610328 CNV loss 21293372
esv3610329 CNV loss 21293372
esv3610330 CNV loss 21293372
esv3610331 CNV loss 21293372
esv3610332 CNV loss 21293372
nsv604483 CNV gain 21841781
nsv830768 CNV gain 17160897

Variation tolerance for ARMC2 Gene

Residual Variation Intolerance Score: 56.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.96; 49.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARMC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARMC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARMC2 Gene

Disorders for ARMC2 Gene

Relevant External Links for ARMC2

Genetic Association Database (GAD)
ARMC2
Human Genome Epidemiology (HuGE) Navigator
ARMC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARMC2

No disorders were found for ARMC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARMC2 Gene

Publications for ARMC2 Gene

  1. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PMID: 21946350) Soler Artigas M. … Tobin M.D. (Nat. Genet. 2011) 3 46 64
  2. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PMID: 20080650) Xu J. … Isaacs W.B. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 46 64
  3. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira A.R. … Marazita M.L. (Genet. Med. 2008) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64

Products for ARMC2 Gene

Sources for ARMC2 Gene

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