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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ARMC2 Gene

protein-coding GIFtS: 41
GCID: GC06P109169

armadillo repeat containing 2

Explore 4 diseases affiliated with
ARMC2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Armadillo Repeat Containing 2¹ ²
BA787I22.1¹
DKFZp434P0714¹
Armadillo Repeat-Containing Protein 2²

External Ids:	HGNC: 23045¹	Entrez Gene: 84071²	Ensembl: ENSG00000118690⁷	UniProtKB: Q8NEN0³

Export aliases for ARMC2 gene to outside databases

Previous GC identifers: GC06P109215 GC06P109276 GC06P106736

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ARMC2 gene promoter:
GR Pax-5 GATA-3 NRSF form 1 NF-kappaB NRSF form 2 MZF-1 NF-kappaB2 GR-alpha NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ARMC2 promoter sequence

Search SABiosciences Chromatin IP Primers for ARMC2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARMC2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21 Ensembl cytogenetic band: 6q21 HGNC cytogenetic band: 6q21

ARMC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARMC2 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P109169: view genomic region (about GC identifiers)

Start:	109,169,619 bp from pter	End:	109,295,352 bp from pter
Size:	125,734 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ARMC2_HUMAN, Q8NEN0 (See protein sequence)

Recommended Name: Armadillo repeat-containing protein 2

Size: 867 amino acids; 96867 Da

Sequence caution: Sequence=AAH30603.2; Type=Erroneous initiation; Sequence=BAF85188.1; Type=Erroneous initiation;

Sequence=CAI16717.2; Type=Erroneous gene model prediction;

Secondary accessions: A8K8Y4 Q5VVY8 Q9H0K9

Explore the universe of human proteins at neXtProt for ARMC2: NX_Q8NEN0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NEN0

ARMC2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_115507.4

ENSEMBL proteins:

ENSP00000376417 ENSP00000237512 ENSP00000393191 ENSP00000357968

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ARMC2 for domains About GeneDecksing

2 InterPro domains/families:

IPR011989 ARM-like

IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry Q8NEN0

ProtoNet protein and cluster: Q8NEN0

UniProtKB/Swiss-Prot: ARMC2_HUMAN, Q8NEN0

Similarity: Contains 12 ARM repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARMC2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ARMC2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for ARMC2 (Q8NEN0³ ENSP00000376417⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IGHG1	P01857³, ENSP00000374990⁴	I2D: score=1 STRING: ENSP00000374990

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ARMC2
Search CenterWatch for drugs/clinical trials and news about ARMC2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ARMC2 gene:

NM_032131.4

Unigene Cluster for ARMC2:

Armadillo repeat containing 2

Hs.645481 [show with all ESTs]

Unigene Representative Sequence: NM_032131

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000392644(uc003pss.4 uc011eao.2) ENST00000237512 ENST00000414610

ENST00000481850 ENST00000368972

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Additional cDNA sequence:

AK095234.1 AK292499.1 AK294574.1 AK309813.1 AK311225.1 AL136754.1 BC030603.2

6 DOTS entries:

DT.86836291 DT.95159388 DT.91737286 DT.121392464 DT.86859729 DT.95299634

24/45 AceView cDNA sequences (see all 45):

NM_032131 AL136754 CB850597 AI336234 AA782532 AI924642 AI878960 AW662841

AI014535 BC030603 BI596500 BX089804 AK095234 AW269841 BI830553 AA324735

BG720375 N48808 BG722130 AI187699 BG723214 BM480242 AW512878 AA922043

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ARMC2 (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c	·	7d	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^
SP1:									-		-		-		-																				-
SP2:									-		-		-		-												-
SP3:															-
SP4:											-		-		-
SP5:									-		-		-

ExUns:	16	^	17	^	18	^	19	^	20
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for ARMC2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ARMC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

ARMC2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Antral Follicle

Secondary Oocyte

Female Gametocytes, Germ Cells

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

See ARMC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARMC2

SOURCE GeneReport for Unigene cluster: Hs.645481

SABiosciences Custom PCR Arrays for ARMC2

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ARMC2 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Armc2^{1 , 5}	armadillo repeat containing 2^{1, 5}	77.48(n)¹ 74(a)¹		10 (22.77 cM)⁵ 213402¹ NM_001034858.3¹ NP_001030030.2¹ 41914990⁵
chicken (Gallus gallus)	Aves	ARMC2¹	armadillo repeat containing 2	66.96(n) 60.42(a)		421767 XM_419797.3 XP_419797.3
lizard (Anolis carolinensis)	Reptilia	ARMC2⁶	--	60(a)	1 ↔ 1	1(190862665-190901600)
zebrafish (Danio rerio)	Actinopterygii	armc2¹	armadillo repeat containing 2	52.89(n) 47(a)		555846 XM_678490.3 XP_683582.3
fruit fly (Drosophila melanogaster)	Insecta	CG32668¹	CG32668	43.5(n) 33.59(a)		318147 NM_167275.1 NP_727502.1

ENSEMBL Gene Tree for ARMC2 (if available)
TreeFam Gene Tree for ARMC2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12199292^1,2	H	--	106764968(+)	`TGCCCG/AGTTCA`	1	--	us2k¹		4		NS EA	418
rs17316075^1,2	H	--	106765123(+)	`TTAGCT/CGAACC`	1	--	us2k¹		7		NA NS EA	562
rs77448216^1,2	F,	--	106765167(+)	`ACACAT/CACGGA`	1	--	us2k¹		1		WA	118
rs9480892^1,2	H	--	106766419(+)	`ACAAAG/TTATCA`	1	--	nc-transcript-variant		4		NS EA	418
rs76988911^1,2	F,	--	106766476(+)	`ACACTG/CTCAAG`	1	--	nc-transcript-variant		1		WA	118
rs74982130^1,2		--	106766562(+)	`AGGTCC/TGGCAG`	1	--	nc-transcript-variant		0	--	--	--	--
rs74460361^1,2	F,	--	106766659(+)	`TGTATT/GCTCCA`	1	--	nc-transcript-variant		1		WA	118
rs79278509^1,2	F,	--	106766706(+)	`GCCATC/TGACAT`	1	--	nc-transcript-variant		1		WA	118
rs72933320^1,2	C,	--	106766870(+)	`CCCACC/GCATCT`	1	--	nc-transcript-variant		0	--	--	--	--
rs76986668^1,2		--	106767471(+)	`GTAAAC/TGTTCA`	1	--	nc-transcript-variant		0	--	--	--	--

HapMap Linkage Disequilibrium report for ARMC2 (109169619 - 109295352 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ARMC2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARMC2

DNA2.0 Custom Variant and Variant Library Synthesis for ARMC2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ARMC2 for disorders About GeneDecksing

4 diseases for ARMC2: About MalaCards

cleft lip/palate cleft lip prostate cancer prostatitis

Human Genome Epidemiology (HuGE) Navigator: ARMC2 (3 documents)

Export disorders for ARMC2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ARMC2 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with ARMC2)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)
Genome-wide association and large-scale follow up iden tifies 16 new loci influencing lung function. (PubMed id 21946350)¹ Soler Artigas M....Tobin M.D. (2011)
Inherited genetic variant predisposes to aggressive b ut not indolent prostate cancer. (PubMed id 20080650)¹ Xu J....Isaacs W.B. (2010)
Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)¹ Vieira A.R....Marazita M.L. (2008)
The LIFEdb database in 2006. (PubMed id 16381901)¹ Mehrle A....Wiemann S. (2006)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)¹ Wiemann S....Poustka A. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)² Mungall A.J.... Beck S. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 84071	HGNC: 23045	AceView: ARMC2	Ensembl:ENSG00000118690	euGenes: HUgn84071
ECgene: ARMC2	H-InvDB: ARMC2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ARMC2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ARMC2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ARMC2 gene:
Search GeneIP for patents involving ARMC2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ARMC2 gene at Home site.

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ARMC2 Gene

armadillo repeat containing 2

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ARMC2 Gene

armadillo repeat containing 2

Aliasesfor ARMC2 gene

Summariesfor ARMC2 gene

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Protein Domains /Familiesfor ARMC2 gene

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