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ARMC2 Gene

protein-coding   GIFtS: 45
GCID: GC06P109169

Armadillo Repeat Containing 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Armadillo Repeat Containing 21 2
Armadillo Repeat-Containing Protein 22
bA787I22.12

External Ids:    HGNC: 230451   Entrez Gene: 840712   Ensembl: ENSG000001186907   UniProtKB: Q8NEN03   

Export aliases for ARMC2 gene to outside databases

Previous GC identifers: GC06P109215 GC06P109276 GC06P106736


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ARMC2 Gene:
ARMC2 (armadillo repeat containing 2) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARMC2 gene promoter:
         GR   Pax-5   GATA-3   NRSF form 1   NF-kappaB   NRSF form 2   MZF-1   NF-kappaB2   GR-alpha   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARMC2 promoter sequence
   Search Chromatin IP Primers for ARMC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARMC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

ARMC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARMC2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P109169:  view genomic region     (about GC identifiers)

Start:
109,169,619 bp from pter      End:
109,295,352 bp from pter
Size:
125,734 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ARMC2_HUMAN, Q8NEN0 (See protein sequence)
Recommended Name: Armadillo repeat-containing protein 2  
Size: 867 amino acids; 96867 Da
Sequence caution: Sequence=AAH30603.2; Type=Erroneous initiation; Sequence=BAF85188.1; Type=Erroneous initiation;
Sequence=CAI16717.2; Type=Erroneous gene model prediction;
Secondary accessions: A8K8Y4 Q5VVY8 Q9H0K9

Explore the universe of human proteins at neXtProt for ARMC2: NX_Q8NEN0

Explore proteomics data for ARMC2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARMC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001273538.1  NP_115507.4  

    ENSEMBL proteins: 
     ENSP00000376417   ENSP00000237512   ENSP00000393191   ENSP00000357968  

    ARMC2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ARMC2

     
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    Cloud-Clone Corp. ELISAs for ARMC2
    Cloud-Clone Corp. CLIAs for ARMC2
    Search eBioscience for ELISAs for ARMC2 
    antibodies-online kits for ARMC2 (30 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARMC: Armadillo repeat containing

    2 InterPro protein domains:
     IPR011989 ARM-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q8NEN0

    ProtoNet protein and cluster: Q8NEN0

    UniProtKB/Swiss-Prot: ARMC2_HUMAN, Q8NEN0
    Similarity: Contains 12 ARM repeats


    Find genes that share domains with ARMC2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
         
    Find genes that share ontologies with ARMC2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ARMC2

    miRNA
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    miRTarBase miRNAs that target ARMC2:
    hsa-mir-155-5p (MIRT020851), hsa-mir-335-5p (MIRT018174)

    Block miRNA regulation of human, mouse, rat ARMC2 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate ARMC2:
    hsa-miR-579 hsa-miR-607 hsa-miR-664 hsa-miR-3680
    SwitchGear 3'UTR luciferase reporter plasmidARMC2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ARMC2
    Predesigned siRNA for gene silencing in human, mouse, rat ARMC2

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    GenScript: all cDNA clones in your preferred vector: ARMC2 (NM_032131)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARMC2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    endoplasmic reticulum1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARMC2
    Interactions:

        Search GeneGlobe Interaction Network for ARMC2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ARMC2 (Q8NEN03 ENSP000003764174) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IGHG1P018573, ENSP000003749904I2D: score=1 STRING: ENSP00000374990
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARMC2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARMC2 gene (2 alternative transcripts): 
    NM_001286609.1  NM_032131.5  

    Unigene Cluster for ARMC2:

    Armadillo repeat containing 2
    Hs.645481  [show with all ESTs]
    Unigene Representative Sequence: NM_032131
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392644(uc003pss.4 uc011eao.2) ENST00000237512 ENST00000414610
    ENST00000481850 ENST00000368972
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate ARMC2:
    hsa-miR-579 hsa-miR-607 hsa-miR-664 hsa-miR-3680
    SwitchGear 3'UTR luciferase reporter plasmidARMC2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ARMC2
    Predesigned siRNA for gene silencing in human, mouse, rat ARMC2
    Clone
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    OriGene ORF clones in mouse, rat for ARMC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARMC2 (NM_032131)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARMC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARMC2
    Primer
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    OriGene qPCR primer pairs and template standards for ARMC2
    OriGene qSTAR qPCR primer pairs in human, mouse for ARMC2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARMC2
      QuantiTect SYBR Green Assays in human, mouse, rat ARMC2
      QuantiFast Probe-based Assays in human, mouse, rat ARMC2

    Additional mRNA sequence: 

    AK095234.1 AK292499.1 AK294574.1 AK309813.1 AK311225.1 AL136754.1 BC030603.2 

    6 DOTS entries:

    DT.86836291  DT.95159388  DT.91737286  DT.121392464  DT.86859729  DT.95299634 

    Selected AceView cDNA sequences (see all 45):

    NM_032131 AI878960 CB850597 AI014535 AI336234 AW662841 AL136754 AI924642 
    BC030603 AA782532 AW269841 AA324735 BG723214 BG720375 BX089804 AK095234 
    BI915280 AI187699 AI187700 CA312750 N48808 BX116058 BG722130 CB266924 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARMC2 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
    SP1:                          -     -     -     -                                                           -                                                   
    SP2:                          -     -     -     -                                   -                                                                           
    SP3:                                            -                                                                                                               
    SP4:                                -     -     -                                                                                                               
    SP5:                          -     -     -                                                                                                                     

    ExUns: 16 ^ 17 ^ 18 ^ 19 ^ 20
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for ARMC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARMC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ARMC2 Expression
    About this image


    ARMC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Secondary Oocyte Antral Follicle
     
     Gonad
             Secondary Oocyte Antral Follicle
    ARMC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARMC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.645481
        Custom PCR Arrays for ARMC2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARMC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARMC2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Armc21 , 5 armadillo repeat containing 21, 5 77.4(n)1
    74(a)1
      10 (22.77 cM)5
    2134021  NM_001034858.31  NP_001030030.21 
     419149905 
    chicken
    (Gallus gallus)
    Aves ARMC21 armadillo repeat containing 2 65.93(n)
    58.36(a)
      421767  XM_419797.4  XP_419797.4 
    lizard
    (Anolis carolinensis)
    Reptilia ARMC26
    armadillo repeat containing 2
    60(a)
    1 ↔ 1
    1(190862665-190904735)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia armc21 armadillo repeat containing 2 60.55(n)
    53.32(a)
      100496180  XM_002940547.2  XP_002940593.2 
    zebrafish
    (Danio rerio)
    Actinopterygii armc21 armadillo repeat containing 2 53.07(n)
    48.13(a)
      555846  XM_678490.4  XP_683582.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG326686
    --
    24(a)
    1 ↔ 1
    X(11050793-11053793)


    ENSEMBL Gene Tree for ARMC2 (if available)
    TreeFam Gene Tree for ARMC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARMC2 (see all 2503)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1508485681,2
    --109167694(+) ATGTTC/TCCACT 1 -- us2k10--------
    rs117541741,2
    C,H--109167774(+) GAAACC/TTAAAA 1 -- us2k10--------
    rs77690801,2
    C,F--109167775(+) AAACCT/CAAAAC 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1851905481,2
    --109167817(+) AAATAA/CGGGGT 1 -- us2k10--------
    rs1144870501,2
    F--109168055(+) TCAGAA/GTCACT 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1894050711,2
    --109168226(+) AACCAG/TAAGCC 1 -- us2k10--------
    rs13274701,2
    C,F,O,A,H--109168234(-) GCTGTA/C/G/
            
    CTGGC
    1 -- us2k127EA NA NS WA 2980
    rs1814401371,2
    --109168278(+) CTCCAA/TCTCCT 1 -- us2k10--------
    rs1865381941,2
    --109168301(+) TCCTCC/TTCACT 1 -- us2k10--------
    rs1915967401,2
    --109168322(+) TCCAAA/GCTGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARMC2 (109169619 - 109295352 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ARMC2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673947CNV Deletion23128226
    esv2656715CNV Deletion23128226
    nsv886532CNV Loss21882294
    nsv830768CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARMC2
    DNA2.0 Custom Variant and Variant Library Synthesis for ARMC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ARMC2           About GenesLikeMe

    Genetic Association Database (GAD): ARMC2
    Human Genome Epidemiology (HuGE) Navigator: ARMC2 (3 documents)

    Export disorders for ARMC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARMC2 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with ARMC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PubMed id 21946350)1, 4 Soler Artigas M....Tobin M.D. (Nat. Genet. 2011)
    2. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PubMed id 20080650)1, 4 Xu J....Isaacs W.B. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    3. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (Genet. Med. 2008)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)
    8. Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. (PubMed id 23284291)1 Hancock D.B....London S.J. (PLoS Genet. 2012)
    9. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (Nucleic Acids Res. 2006)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84071 HGNC: 23045 AceView: ARMC2 Ensembl:ENSG00000118690 euGenes: HUgn84071
    ECgene: ARMC2 H-InvDB: ARMC2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARMC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARMC2 gene:
    Search GeneIP for patents involving ARMC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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