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Aliases for ARMC2 Gene

Aliases for ARMC2 Gene

  • Armadillo Repeat Containing 2 2 3 5
  • BA787I22.1 3

External Ids for ARMC2 Gene

Previous GeneCards Identifiers for ARMC2 Gene

  • GC06P109215
  • GC06P109276
  • GC06P106736
  • GC06P109169

Summaries for ARMC2 Gene

GeneCards Summary for ARMC2 Gene

ARMC2 (Armadillo Repeat Containing 2) is a Protein Coding gene. GO annotations related to this gene include binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARMC2 Gene

Genomics for ARMC2 Gene

Regulatory Elements for ARMC2 Gene

Promoters for ARMC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARMC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARMC2 Gene

108,848,414 bp from pter
108,998,506 bp from pter
150,093 bases
Plus strand

Genomic View for ARMC2 Gene

Genes around ARMC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARMC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARMC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARMC2 Gene

Proteins for ARMC2 Gene

  • Protein details for ARMC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Armadillo repeat-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K8Y4
    • B4DGF5
    • G5E993
    • Q5VVY8
    • Q9H0K9

    Protein attributes for ARMC2 Gene

    867 amino acids
    Molecular mass:
    96867 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH30603.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAF85188.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI16717.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ARMC2 Gene


neXtProt entry for ARMC2 Gene

Proteomics data for ARMC2 Gene at MOPED

Post-translational modifications for ARMC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARMC2 Gene

No data available for DME Specific Peptides for ARMC2 Gene

Domains & Families for ARMC2 Gene

Gene Families for ARMC2 Gene

Protein Domains for ARMC2 Gene


Suggested Antigen Peptide Sequences for ARMC2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 12 ARM repeats.
  • Contains 12 ARM repeats.
genes like me logo Genes that share domains with ARMC2: view

Function for ARMC2 Gene

genes like me logo Genes that share phenotypes with ARMC2: view

Animal Model Products

miRNA for ARMC2 Gene

miRTarBase miRNAs that target ARMC2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARMC2 Gene

Localization for ARMC2 Gene

Subcellular locations from

Jensen Localization Image for ARMC2 Gene COMPARTMENTS Subcellular localization image for ARMC2 gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ARMC2 Gene

Pathways & Interactions for ARMC2 Gene

SuperPathways for ARMC2 Gene

No Data Available

Interacting Proteins for ARMC2 Gene

Selected Interacting proteins: Q8NEN0-ARMC2_HUMAN for ARMC2 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for ARMC2 Gene


No data available for Pathways by source and SIGNOR curated interactions for ARMC2 Gene

Drugs & Compounds for ARMC2 Gene

No Compound Related Data Available

Transcripts for ARMC2 Gene

Unigene Clusters for ARMC2 Gene

Armadillo repeat containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARMC2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
SP1: - - - - -
SP2: - - - - -
SP3: -
SP4: - - -
SP5: - - -
SP6: - - - - - - -
SP7: - - - - - -

ExUns: 16 ^ 17 ^ 18 ^ 19 ^ 20

Relevant External Links for ARMC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARMC2 Gene

mRNA expression in normal human tissues for ARMC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARMC2 Gene

This gene is overexpressed in Testis (x5.4).

Protein differential expression in normal tissues from HIPED for ARMC2 Gene

This gene is overexpressed in Plasma (46.9) and Serum (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARMC2 Gene

SOURCE GeneReport for Unigene cluster for ARMC2 Gene Hs.645481

genes like me logo Genes that share expression patterns with ARMC2: view

Protein tissue co-expression partners for ARMC2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ARMC2 Gene

Orthologs for ARMC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARMC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARMC2 35
  • 87.17 (n)
  • 83.24 (a)
ARMC2 36
  • 76 (a)
(Canis familiaris)
Mammalia ARMC2 35
  • 88.47 (n)
  • 85.8 (a)
ARMC2 36
  • 86 (a)
(Mus musculus)
Mammalia Armc2 35
  • 77.4 (n)
  • 74 (a)
Armc2 16
Armc2 36
  • 71 (a)
(Pan troglodytes)
Mammalia ARMC2 35
  • 99.46 (n)
  • 99.19 (a)
ARMC2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Armc2 35
  • 76.92 (n)
  • 74.15 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 76 (a)
-- 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia ARMC2 36
  • 55 (a)
(Gallus gallus)
Aves ARMC2 35
  • 65.93 (n)
  • 58.36 (a)
ARMC2 36
  • 57 (a)
(Anolis carolinensis)
Reptilia ARMC2 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia armc2 35
  • 60.55 (n)
  • 53.32 (a)
(Danio rerio)
Actinopterygii armc2 35
  • 53.07 (n)
  • 48.13 (a)
armc2 36
  • 44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32668 36
  • 24 (a)
Species with no ortholog for ARMC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARMC2 Gene

Gene Tree for ARMC2 (if available)
Gene Tree for ARMC2 (if available)

Paralogs for ARMC2 Gene

No data available for Paralogs for ARMC2 Gene

Variants for ARMC2 Gene

Sequence variations from dbSNP and Humsavar for ARMC2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs9386758 - 108,876,176(+) AGTTA(C/T)GATGG nc-transcript-variant, upstream-variant-2KB, reference, missense
VAR_031949 -
rs396575 -- 108,982,946(+) ctcca(A/G)agtaa intron-variant
rs434225 -- 108,962,925(+) gccca(A/G)aagtt intron-variant
rs445221 -- 108,968,389(-) TGCAC(A/G)AGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARMC2 Gene

Variant ID Type Subtype PubMed ID
nsv830768 CNV Gain 17160897
esv2673947 CNV Deletion 23128226
esv2656715 CNV Deletion 23128226
nsv886532 CNV Loss 21882294

Variation tolerance for ARMC2 Gene

Residual Variation Intolerance Score: 56.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.96; 49.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARMC2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARMC2 Gene

Disorders for ARMC2 Gene

Relevant External Links for ARMC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARMC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARMC2 Gene

Publications for ARMC2 Gene

  1. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PMID: 21946350) Soler Artigas M. … Tobin M.D. (Nat. Genet. 2011) 3 48 67
  2. Promyelocytic Leukemia protein (PML) interacts with ASC to limit Inflammasome Activation. (PMID: 24407287) Dowling J.K. … O'Neill L.A. (J. Biol. Chem. 2014) 3
  3. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3
  4. Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. (PMID: 23284291) Hancock D.B. … London S.J. (PLoS Genet. 2012) 3
  5. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PMID: 20080650) Xu J. … Isaacs W.B. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3

Products for ARMC2 Gene

Sources for ARMC2 Gene

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