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Aliases for ARMC12 Gene

Aliases for ARMC12 Gene

  • Armadillo Repeat Containing 12 2 3 5
  • C6orf81 3 4
  • Armadillo Repeat-Containing Protein 12 3
  • Chromosome 6 Open Reading Frame 81 2

External Ids for ARMC12 Gene

Previous HGNC Symbols for ARMC12 Gene

  • C6orf81

Previous GeneCards Identifiers for ARMC12 Gene

  • GC06P035705
  • GC06P035821
  • GC06P036312
  • GC06P037299
  • GC06P036829
  • GC06P036910
  • GC06P037773
  • GC06P038397

Summaries for ARMC12 Gene

GeneCards Summary for ARMC12 Gene

ARMC12 (Armadillo Repeat Containing 12) is a Protein Coding gene. GO annotations related to this gene include binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARMC12 Gene

Genomics for ARMC12 Gene

Regulatory Elements for ARMC12 Gene

Enhancers for ARMC12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F035689 0.4 ENCODE 13.1 -43.9 -43927 0.2 THRAP3 ZMYM3 ZBTB33 MLLT1 FKBP5 ARMC12 ENSG00000232909 ENSG00000212579 ENSG00000237719 ENSG00000219023 FANCE SRPK1 MAPK14 RPL10A
GH06F035686 0.2 ENCODE 13.1 -46.0 -45988 3.6 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 ENSG00000272374 FKBP5 ARMC12 ENSG00000232909 ENSG00000212579 ENSG00000237719 ENSG00000219023 FANCE SRPK1 MAPK14
GH06F035690 0.9 Ensembl ENCODE 12.8 -42.1 -42061 2.1 TGIF2 ATF3 CEBPA MAX ZBTB33 FOXP2 RAD21 YY1 FKBP5 ARMC12 ENSG00000232909 ENSG00000212579 ZNF76 MIR5690
GH06F035676 1.1 Ensembl ENCODE 12.6 -56.1 -56069 2.7 PKNOX1 CEBPB MAFG MNT SCRT2 NFE2 ZBTB33 EMSY PRDM1 SP7 ENSG00000212579 FKBP5 ARMC12 ENSG00000232909 MIR5690
GH06F035675 0.5 Ensembl 12.6 -58.3 -58305 0.2 BCOR ZMYM3 EMSY ENSG00000212579 FKBP5 ARMC12 ENSG00000232909 MIR5690
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ARMC12 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARMC12 Gene

Chromosome:
6
Start:
35,733,805 bp from pter
End:
35,749,079 bp from pter
Size:
15,275 bases
Orientation:
Plus strand

Genomic View for ARMC12 Gene

Genes around ARMC12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARMC12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARMC12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARMC12 Gene

Proteins for ARMC12 Gene

  • Protein details for ARMC12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T9G4-ARM12_HUMAN
    Recommended name:
    Armadillo repeat-containing protein 12
    Protein Accession:
    Q5T9G4
    Secondary Accessions:
    • Q8NEB2
    • Q96LL8

    Protein attributes for ARMC12 Gene

    Size:
    340 amino acids
    Molecular mass:
    38632 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ARMC12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARMC12 Gene

Post-translational modifications for ARMC12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARMC12 Gene

Domains & Families for ARMC12 Gene

Gene Families for ARMC12 Gene

Protein Domains for ARMC12 Gene

Graphical View of Domain Structure for InterPro Entry

Q5T9G4

UniProtKB/Swiss-Prot:

ARM12_HUMAN :
  • Contains 3 ARM repeats.
Similarity:
  • Contains 3 ARM repeats.
genes like me logo Genes that share domains with ARMC12: view

No data available for Suggested Antigen Peptide Sequences for ARMC12 Gene

Function for ARMC12 Gene

genes like me logo Genes that share phenotypes with ARMC12: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARMC12 Gene

Localization for ARMC12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARMC12 Gene COMPARTMENTS Subcellular localization image for ARMC12 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ARMC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
genes like me logo Genes that share ontologies with ARMC12: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARMC12 Gene

Pathways & Interactions for ARMC12 Gene

SuperPathways for ARMC12 Gene

No Data Available

Interacting Proteins for ARMC12 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000288065%0d%0a9606.ENSP00000363822%0d%0a9606.ENSP00000381891%0d%0a
Selected Interacting proteins: ENSP00000288065 Q5T9G4-ARM12_HUMAN for ARMC12 Gene via STRING IID

Gene Ontology (GO) - Biological Process for ARMC12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ARMC12 Gene

Transcripts for ARMC12 Gene

Unigene Clusters for ARMC12 Gene

Armadillo repeat containing 12:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARMC12 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - -
SP2:
SP3: -

Relevant External Links for ARMC12 Gene

GeneLoc Exon Structure for
ARMC12
ECgene alternative splicing isoforms for
ARMC12

Expression for ARMC12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARMC12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARMC12 Gene

This gene is overexpressed in Testis (x17.9).

Protein differential expression in normal tissues from HIPED for ARMC12 Gene

This gene is overexpressed in Testis (26.5), Fetal gut (16.9), Spleen (13.4), and Ovary (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARMC12 Gene



Protein tissue co-expression partners for ARMC12 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARMC12 Gene:

ARMC12

SOURCE GeneReport for Unigene cluster for ARMC12 Gene:

Hs.533066
genes like me logo Genes that share expression patterns with ARMC12: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ARMC12 Gene

Orthologs for ARMC12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ARMC12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARMC12 34 35
  • 98.79 (n)
dog
(Canis familiaris)
Mammalia ARMC12 34 35
  • 89.55 (n)
cow
(Bos Taurus)
Mammalia ARMC12 34 35
  • 87.5 (n)
mouse
(Mus musculus)
Mammalia Armc12 34 16 35
  • 84.12 (n)
rat
(Rattus norvegicus)
Mammalia Armc12 34
  • 81.67 (n)
oppossum
(Monodelphis domestica)
Mammalia ARMC12 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARMC12 35
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 54 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
Species where no ortholog for ARMC12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ARMC12 Gene

ENSEMBL:
Gene Tree for ARMC12 (if available)
TreeFam:
Gene Tree for ARMC12 (if available)

Paralogs for ARMC12 Gene

No data available for Paralogs for ARMC12 Gene

Variants for ARMC12 Gene

Sequence variations from dbSNP and Humsavar for ARMC12 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs193921111 Uncertain significance 35,747,417(+) AGTCA(G/T)ACTAC reference, missense
rs386352286 Uncertain significance 35,737,299(+) GAGGG(C/T)TCTGC intron-variant, upstream-variant-2KB, reference, missense
rs1075091 -- 35,745,710(-) agcga(C/G)gtccc intron-variant
rs1075092 -- 35,745,649(-) taata(G/T)caaaa intron-variant
rs10947566 -- 35,734,291(+) aatag(C/T)tggga intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ARMC12 Gene

Variant ID Type Subtype PubMed ID
esv2759420 CNV gain 17122850
esv3608689 CNV gain 21293372
esv3608690 CNV gain 21293372
esv3890842 CNV gain 25118596
nsv1028947 CNV gain 25217958
nsv428143 CNV gain 18775914
nsv602924 CNV gain 21841781
nsv821646 CNV loss 15273396

Variation tolerance for ARMC12 Gene

Residual Variation Intolerance Score: 79.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARMC12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARMC12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARMC12 Gene

Disorders for ARMC12 Gene

Relevant External Links for ARMC12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARMC12

No disorders were found for ARMC12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARMC12 Gene

Publications for ARMC12 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 64

Products for ARMC12 Gene

Sources for ARMC12 Gene

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