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Aliases for ARMC10 Gene

Aliases for ARMC10 Gene

  • Armadillo Repeat Containing 10 2 3 5
  • Specific Splicing Variant Involved In Hepatocarcinogenesis 2 3
  • Splicing Variant Involved In Hepatocarcinogenesis Protein 3 4
  • SVH 3 4
  • PNAS-112 3
  • PSEC0198 3
  • PNAS112 3

External Ids for ARMC10 Gene

Previous GeneCards Identifiers for ARMC10 Gene

  • GC07P102503
  • GC07P102715
  • GC07P097078

Summaries for ARMC10 Gene

Entrez Gene Summary for ARMC10 Gene

  • This gene encodes a protein that contains an armadillo repeat and transmembrane domain. The encoded protein decreases the transcriptional activity of the tumor suppressor protein p53 through direct interaction with the DNA-binding domain of p53, and may play a role in cell growth and survival. Upregulation of this gene may play a role in hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Sep 2011]

GeneCards Summary for ARMC10 Gene

ARMC10 (Armadillo Repeat Containing 10) is a Protein Coding gene. Diseases associated with ARMC10 include lateral medullary syndrome and cloacogenic carcinoma. GO annotations related to this gene include binding and hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances. An important paralog of this gene is ARMCX6.

UniProtKB/Swiss-Prot for ARMC10 Gene

  • May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARMC10 Gene

Genomics for ARMC10 Gene

Regulatory Elements for ARMC10 Gene

Enhancers for ARMC10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARMC10 on UCSC Golden Path with GeneCards custom track

Promoters for ARMC10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARMC10 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARMC10 Gene

Chromosome:
7
Start:
103,074,727 bp from pter
End:
103,099,764 bp from pter
Size:
25,038 bases
Orientation:
Plus strand

Genomic View for ARMC10 Gene

Genes around ARMC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARMC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARMC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARMC10 Gene

Proteins for ARMC10 Gene

  • Protein details for ARMC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N2F6-ARM10_HUMAN
    Recommended name:
    Armadillo repeat-containing protein 10
    Protein Accession:
    Q8N2F6
    Secondary Accessions:
    • A8K703
    • B4DWJ8
    • F5GX65
    • Q75K91
    • Q75MG6
    • Q75ML8
    • Q8IZC1
    • Q8IZC2
    • Q8IZC3
    • Q9BTM6

    Protein attributes for ARMC10 Gene

    Size:
    343 amino acids
    Molecular mass:
    37540 Da
    Quaternary structure:
    • Interacts with the DNA-binding domain of p53/TP53.
    Miscellaneous:
    • Depletion of isoform 2 results in cell apoptosis while its overexpression in cells leads to accelerated growth rate and tumorogenicity.
    SequenceCaution:
    • Sequence=AAS07482.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ARMC10 Gene

neXtProt entry for ARMC10 Gene

Proteomics data for ARMC10 Gene at MOPED

Post-translational modifications for ARMC10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARMC10 Gene

Domains & Families for ARMC10 Gene

Gene Families for ARMC10 Gene

Protein Domains for ARMC10 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N2F6

UniProtKB/Swiss-Prot:

ARM10_HUMAN :
  • Contains 1 ARM repeat.
Similarity:
  • Contains 1 ARM repeat.
genes like me logo Genes that share domains with ARMC10: view

Function for ARMC10 Gene

Molecular function for ARMC10 Gene

UniProtKB/Swiss-Prot Function:
May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53.

Phenotypes for ARMC10 Gene

GenomeRNAi human phenotypes for ARMC10:
genes like me logo Genes that share phenotypes with ARMC10: view

Animal Model Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARMC10 Gene

Localization for ARMC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARMC10 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARMC10 Gene COMPARTMENTS Subcellular localization image for ARMC10 gene
Compartment Confidence
mitochondrion 4
endoplasmic reticulum 3
extracellular 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ARMC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ARMC10: view

Pathways & Interactions for ARMC10 Gene

SuperPathways for ARMC10 Gene

No Data Available

Interacting Proteins for ARMC10 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000319412%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q8N2F6-ARM10_HUMAN ENSP00000319412 for ARMC10 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for ARMC10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ARMC10 Gene

Drugs & Compounds for ARMC10 Gene

No Compound Related Data Available

Transcripts for ARMC10 Gene

Unigene Clusters for ARMC10 Gene

Armadillo repeat containing 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARMC10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - - -
SP2: -
SP3: - - - -
SP4: - -
SP5: - - - - -
SP6: - -
SP7:
SP8: - - - - - -
SP9: - -

Relevant External Links for ARMC10 Gene

GeneLoc Exon Structure for
ARMC10
ECgene alternative splicing isoforms for
ARMC10

Expression for ARMC10 Gene

mRNA expression in normal human tissues for ARMC10 Gene

Protein differential expression in normal tissues from HIPED for ARMC10 Gene

This gene is overexpressed in Nasal epithelium (18.7) and Serum (17.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ARMC10 Gene



SOURCE GeneReport for Unigene cluster for ARMC10 Gene Hs.287412

mRNA Expression by UniProt/SwissProt for ARMC10 Gene

Q8N2F6-ARM10_HUMAN
Tissue specificity: Expressed in all tissues tested with higher expression in placenta, liver, kidney, heart and brain.
genes like me logo Genes that share expression patterns with ARMC10: view

Protein tissue co-expression partners for ARMC10 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ARMC10 Gene

Orthologs for ARMC10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ARMC10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARMC10 35
  • 84.58 (n)
  • 81.11 (a)
ARMC10 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARMC10 35
  • 85.84 (n)
  • 80.72 (a)
ARMC10 36
  • 52 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Armc10 35
  • 81.26 (n)
  • 79.74 (a)
Armc10 16
Armc10 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARMC10 35
  • 99.42 (n)
  • 99.13 (a)
ARMC10 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Armc10 35
  • 80.83 (n)
  • 77.45 (a)
oppossum
(Monodelphis domestica)
Mammalia ARMC10 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
OneToMany
chicken
(Gallus gallus)
Aves ARMC10 35
  • 60.93 (n)
  • 45.88 (a)
-- 36
  • 43 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 44 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia armc10 35
  • 54.7 (n)
  • 42.62 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC557740 35
  • 47.63 (n)
  • 36.63 (a)
ARMCX3 36
  • 31 (a)
OneToMany
Species with no ortholog for ARMC10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARMC10 Gene

ENSEMBL:
Gene Tree for ARMC10 (if available)
TreeFam:
Gene Tree for ARMC10 (if available)

Paralogs for ARMC10 Gene

Paralogs for ARMC10 Gene

(4) SIMAP similar genes for ARMC10 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ARMC10: view

Variants for ARMC10 Gene

Sequence variations from dbSNP and Humsavar for ARMC10 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs17849774 - 103,092,516(+) CTGGT(C/T)CTCTG intron-variant, reference, missense, utr-variant-3-prime
rs1061844 -- 103,098,741(+) AAGAG(C/T)TTGTA utr-variant-3-prime
rs6955354 -- 103,092,111(+) gcgga(A/T)cgcga intron-variant
rs6955481 -- 103,092,165(+) GTCTC(C/T)ACTAA intron-variant
rs6958836 -- 103,076,937(+) aggct(C/T)ggtgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARMC10 Gene

Variant ID Type Subtype PubMed ID
esv2752138 CNV Loss 17911159
nsv526764 CNV Loss 19592680
esv2674575 CNV Deletion 23128226

Variation tolerance for ARMC10 Gene

Residual Variation Intolerance Score: 73.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.69; 66.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARMC10 Gene

HapMap Linkage Disequilibrium report
ARMC10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARMC10 Gene

Disorders for ARMC10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ARMC10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
lateral medullary syndrome
  • vertebral artery syndrome
cloacogenic carcinoma
  • cloacogenic anal carcinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ARMC10

Genetic Association Database (GAD)
ARMC10
Human Genome Epidemiology (HuGE) Navigator
ARMC10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARMC10
genes like me logo Genes that share disorders with ARMC10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARMC10 Gene

Publications for ARMC10 Gene

  1. A specific splicing variant of SVH, a novel human armadillo repeat protein, is up-regulated in hepatocellular carcinomas. (PMID: 12839973) Huang R. … Hu G. (Cancer Res. 2003) 2 3 4 23 67
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3
  4. HSP27 and HSP70 interact with CD10 in C4-2 prostate cancer cells. (PMID: 17342744) Dall'Era M.A. … Liu A.Y. (Prostate 2007) 3
  5. SVH-B interacts directly with p53 and suppresses the transcriptional activity of p53. (PMID: 17904127) Zhou X. … Hu G. (FEBS Lett. 2007) 3

Products for ARMC10 Gene

Sources for ARMC10 Gene

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