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Aliases for ARMC10 Gene

Aliases for ARMC10 Gene

  • Armadillo Repeat Containing 10 2 3
  • SVH 3 4 6
  • Specific Splicing Variant Involved In Hepatocarcinogenesis 2 3
  • Splicing Variant Involved In Hepatocarcinogenesis Protein 3 4
  • Armadillo Repeat-Containing Protein 10 3
  • PNAS-112 3
  • PSEC0198 3
  • PNAS112 3

External Ids for ARMC10 Gene

Summaries for ARMC10 Gene

Entrez Gene Summary for ARMC10 Gene

  • This gene encodes a protein that contains an armadillo repeat and transmembrane domain. The encoded protein decreases the transcriptional activity of the tumor suppressor protein p53 through direct interaction with the DNA-binding domain of p53, and may play a role in cell growth and survival. Upregulation of this gene may play a role in hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Sep 2011]

GeneCards Summary for ARMC10 Gene

ARMC10 (Armadillo Repeat Containing 10) is a Protein Coding gene. Diseases associated with ARMC10 include hepatocellular carcinoma and cloacogenic carcinoma. An important paralog of this gene is ARMCX6.

UniProtKB/Swiss-Prot for ARMC10 Gene

  • May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARMC10 Gene

Genomics for ARMC10 Gene

Genomic Location for ARMC10 Gene

Start:
103,074,727 bp from pter
End:
103,099,764 bp from pter
Size:
25,038 bases
Orientation:
Plus strand

Genomic View for ARMC10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARMC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARMC10 Gene

Regulatory Elements for ARMC10 Gene

Proteins for ARMC10 Gene

  • Protein details for ARMC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N2F6-ARM10_HUMAN
    Recommended name:
    Armadillo repeat-containing protein 10
    Protein Accession:
    Q8N2F6
    Secondary Accessions:
    • A8K703
    • B4DWJ8
    • F5GX65
    • Q75K91
    • Q75MG6
    • Q75ML8
    • Q8IZC1
    • Q8IZC2
    • Q8IZC3
    • Q9BTM6

    Protein attributes for ARMC10 Gene

    Size:
    343 amino acids
    Molecular mass:
    37540 Da
    Quaternary structure:
    • Interacts with the DNA-binding domain of p53/TP53.
    Miscellaneous:
    • Depletion of isoform 2 results in cell apoptosis while its overexpression in cells leads to accelerated growth rate and tumorogenicity
    SequenceCaution:
    • Sequence=AAS07482.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ARMC10 Gene

neXtProt entry for ARMC10 Gene

Proteomics data for ARMC10 Gene at MOPED

Post-translational modifications for ARMC10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARMC10 Gene

Domains for ARMC10 Gene

Gene Families for ARMC10 Gene

HGNC:
  • ARMC :Armadillo repeat containing

Protein Domains for ARMC10 Gene

UniProtKB/Swiss-Prot:

ARM10_HUMAN
Similarity:
  • Contains 1 ARM repeat.:
    • Q8N2F6
genes like me logo Genes that share domains with ARMC10: view

Function for ARMC10 Gene

Molecular function for ARMC10 Gene

UniProtKB/Swiss-Prot Function: May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53.

Gene Ontology (GO) - Molecular Function for ARMC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances --
genes like me logo Genes that share ontologies with ARMC10: view

miRNA for ARMC10 Gene

miRTarBase miRNAs that target ARMC10

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARMC10 Gene

Localization for ARMC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARMC10 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARMC10 Gene COMPARTMENTS Subcellular localization image for ARMC10 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 3
extracellular 2
lysosome 1

Gene Ontology (GO) - Cellular Components for ARMC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain --
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ARMC10: view

Pathways for ARMC10 Gene

SuperPathways for ARMC10 Gene

No Data Available

Interacting Proteins for ARMC10 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000319412%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000319412 Q8N2F6-ARM10_HUMAN for ARMC10 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for ARMC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015991 ATP hydrolysis coupled proton transport --
GO:0040008 regulation of growth IEA --
genes like me logo Genes that share ontologies with ARMC10: view

No data available for Pathways by source for ARMC10 Gene

Transcripts for ARMC10 Gene

Unigene Clusters for ARMC10 Gene

Armadillo repeat containing 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARMC10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - - -
SP2: -
SP3: - - - -
SP4: - -
SP5: - - - - -
SP6: - -
SP7:
SP8: - - - - - -
SP9: - -

Relevant External Links for ARMC10 Gene

GeneLoc Exon Structure for
ARMC10
ECgene alternative splicing isoforms for
ARMC10

Expression for ARMC10 Gene

mRNA expression in normal human tissues for ARMC10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ARMC10 Gene

SOURCE GeneReport for Unigene cluster for ARMC10 Gene Hs.287412

mRNA Expression by UniProt/SwissProt for ARMC10 Gene

Q8N2F6-ARM10_HUMAN
Tissue specificity: Expressed in all tissues tested with higher expression in placenta, liver, kidney, heart and brain.
genes like me logo Genes that share expressions with ARMC10: view

Orthologs for ARMC10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ARMC10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARMC10 36
  • 99.42 (n)
  • 99.13 (a)
ARMC10 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARMC10 36
  • 84.58 (n)
  • 81.11 (a)
ARMC10 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARMC10 36
  • 85.84 (n)
  • 80.72 (a)
ARMC10 37
  • 52 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Armc10 36
  • 81.26 (n)
  • 79.74 (a)
Armc10 16
Armc10 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARMC10 37
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 53 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Armc10 36
  • 80.83 (n)
  • 77.45 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 43 (a)
OneToMany
ARMC10 36
  • 60.93 (n)
  • 45.88 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 44 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia armc10 36
  • 54.7 (n)
  • 42.62 (a)
zebrafish
(Danio rerio)
Actinopterygii ARMCX3 37
  • 31 (a)
OneToMany
LOC557740 36
  • 47.63 (n)
  • 36.63 (a)
Species with no ortholog for ARMC10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARMC10 Gene

ENSEMBL:
Gene Tree for ARMC10 (if available)
TreeFam:
Gene Tree for ARMC10 (if available)

Paralogs for ARMC10 Gene

Paralogs for ARMC10 Gene

Selected SIMAP similar genes for ARMC10 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ARMC10: view

Variants for ARMC10 Gene

Sequence variations from dbSNP and Humsavar for ARMC10 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs14029 -- 103,098,415(-) TGCAC(A/G)GCTAA synonymous-codon, reference
rs1061844 -- 103,098,741(+) AAGAG(C/T)TTGTA utr-variant-3-prime
rs1524419 -- 103,079,372(-) CTGCA(A/G)GTTTT intron-variant
rs1861728 -- 103,097,953(-) TCATT(A/T)TTTCA intron-variant
rs1861729 -- 103,097,753(-) GCTTC(A/G)TGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARMC10 Gene

Variant ID Type Subtype PubMed ID
esv2752138 CNV Loss 17911159
nsv526764 CNV Loss 19592680
esv2674575 CNV Deletion 23128226

Relevant External Links for ARMC10 Gene

HapMap Linkage Disequilibrium report
ARMC10

Disorders for ARMC10 Gene

(1) University of Copenhagen DISEASES for ARMC10 Gene

Relevant External Links for ARMC10

Genetic Association Database (GAD)
ARMC10
Human Genome Epidemiology (HuGE) Navigator
ARMC10
genes like me logo Genes that share disorders with ARMC10: view

No data available for UniProtKB/Swiss-Prot for ARMC10 Gene

Publications for ARMC10 Gene

  1. A specific splicing variant of SVH, a novel human armadillo repeat protein, is up-regulated in hepatocellular carcinomas. (PMID: 12839973) Huang R. … Hu G. (Cancer Res. 2003) 2 3 4 23
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  5. SVH-B interacts directly with p53 and suppresses the transcriptional activity of p53. (PMID: 17904127) Zhou X. … Hu G. (FEBS Lett. 2007) 3 4

Products for ARMC10 Gene

Sources for ARMC10 Gene

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