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Aliases for ARMC10 Gene

Aliases for ARMC10 Gene

  • Armadillo Repeat Containing 10 2 3 5
  • Specific Splicing Variant Involved In Hepatocarcinogenesis 2 3
  • Splicing Variant Involved In Hepatocarcinogenesis Protein 3 4
  • SVH 3 4
  • Armadillo Repeat-Containing Protein 10 3
  • PNAS-112 3
  • PSEC0198 3
  • PNAS112 3

External Ids for ARMC10 Gene

Previous GeneCards Identifiers for ARMC10 Gene

  • GC07P102503
  • GC07P102715
  • GC07P097078

Summaries for ARMC10 Gene

Entrez Gene Summary for ARMC10 Gene

  • This gene encodes a protein that contains an armadillo repeat and transmembrane domain. The encoded protein decreases the transcriptional activity of the tumor suppressor protein p53 through direct interaction with the DNA-binding domain of p53, and may play a role in cell growth and survival. Upregulation of this gene may play a role in hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Sep 2011]

GeneCards Summary for ARMC10 Gene

ARMC10 (Armadillo Repeat Containing 10) is a Protein Coding gene. Diseases associated with ARMC10 include Lateral Medullary Syndrome and Cloacogenic Carcinoma. GO annotations related to this gene include binding and hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances. An important paralog of this gene is ARMCX3.

UniProtKB/Swiss-Prot for ARMC10 Gene

  • May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53.

Additional gene information for ARMC10 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARMC10 Gene

Genomics for ARMC10 Gene

Regulatory Elements for ARMC10 Gene

Enhancers for ARMC10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H102987 1.6 Ensembl ENCODE dbSUPER 10.9 -83.4 -83363 6.9 HDGF PKNOX1 FOXA2 ARNT FEZF1 ZNF2 ZNF766 CBX5 FOS DEK PRKRIP1 ENSG00000213385 CRYZP1 ENSG00000239486 DNAJC2 PMPCB ALKBH4 DPY19L2P2 LRRC17 ARMC10
GH07H102870 1.8 FANTOM5 Ensembl ENCODE dbSUPER 6.2 -200.7 -200734 6.3 PKNOX1 FOXA2 SIN3A ATF7 FOS RUNX3 JUNB PPARG ZNF592 NFIL3 LRRC17 CRYZP1 FAM185A ENSG00000213385 POLR2J3 UPK3BL1 ARMC10 ORAI2 LRWD1 RN7SKP198
GH07H103073 1.1 ENCODE 10.1 +0.4 369 2.7 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF143 ZNF207 SP3 ENSG00000213385 CRYZP1 PRKRIP1 PMPCB FAM185A DNAJC2 NAPEPLD ARMC10 FBXL13 GC07M103088
GH07H102912 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6.5 -159.4 -159420 6 ELF3 CTCF PKNOX1 JUN RAD21 ZNF316 ZNF366 ZNF547 PATZ1 FOS RNU6-1136P FBXL13 DPY19L2P2 ARMC10 LRRC17 RASA4 RPL23AP95 NFE4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARMC10 on UCSC Golden Path with GeneCards custom track

Promoters for ARMC10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000216192 473 2001 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF143 ZNF207 SP3

Genomic Locations for ARMC10 Gene

Genomic Locations for ARMC10 Gene
25,038 bases
Plus strand

Genomic View for ARMC10 Gene

Genes around ARMC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARMC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARMC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARMC10 Gene

Proteins for ARMC10 Gene

  • Protein details for ARMC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Armadillo repeat-containing protein 10
    Protein Accession:
    Secondary Accessions:
    • A8K703
    • B4DWJ8
    • F5GX65
    • Q75K91
    • Q75MG6
    • Q75ML8
    • Q8IZC1
    • Q8IZC2
    • Q8IZC3
    • Q9BTM6

    Protein attributes for ARMC10 Gene

    343 amino acids
    Molecular mass:
    37540 Da
    Quaternary structure:
    • Interacts with the DNA-binding domain of p53/TP53.
    • Depletion of isoform 2 results in cell apoptosis while its overexpression in cells leads to accelerated growth rate and tumorogenicity.
    • Sequence=AAS07482.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ARMC10 Gene

neXtProt entry for ARMC10 Gene

Post-translational modifications for ARMC10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARMC10 Gene

Domains & Families for ARMC10 Gene

Gene Families for ARMC10 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ARMC10 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARMC10: view

No data available for UniProtKB/Swiss-Prot for ARMC10 Gene

Function for ARMC10 Gene

Molecular function for ARMC10 Gene

UniProtKB/Swiss-Prot Function:
May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53.

Phenotypes From GWAS Catalog for ARMC10 Gene

Phenotypes for ARMC10 Gene

GenomeRNAi human phenotypes for ARMC10:
genes like me logo Genes that share phenotypes with ARMC10: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARMC10 Gene

Localization for ARMC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARMC10 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARMC10 gene
Compartment Confidence
mitochondrion 4
endoplasmic reticulum 3
extracellular 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ARMC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IEA,IDA 12839973
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ARMC10: view

Pathways & Interactions for ARMC10 Gene

SuperPathways for ARMC10 Gene

No Data Available

Interacting Proteins for ARMC10 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000319412 Q8N2F6-ARM10_HUMAN for ARMC10 Gene via STRING IID

Gene Ontology (GO) - Biological Process for ARMC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0040008 regulation of growth IEA --
genes like me logo Genes that share ontologies with ARMC10: view

No data available for Pathways by source and SIGNOR curated interactions for ARMC10 Gene

Drugs & Compounds for ARMC10 Gene

No Compound Related Data Available

Transcripts for ARMC10 Gene

Unigene Clusters for ARMC10 Gene

Armadillo repeat containing 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARMC10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - - -
SP2: -
SP3: - - - -
SP4: - -
SP5: - - - - -
SP6: - -
SP8: - - - - - -
SP9: - -

Relevant External Links for ARMC10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARMC10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARMC10 Gene

Protein differential expression in normal tissues from HIPED for ARMC10 Gene

This gene is overexpressed in Nasal epithelium (18.7) and Serum (17.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARMC10 Gene

Protein tissue co-expression partners for ARMC10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARMC10 Gene:


SOURCE GeneReport for Unigene cluster for ARMC10 Gene:


mRNA Expression by UniProt/SwissProt for ARMC10 Gene:

Tissue specificity: Expressed in all tissues tested with higher expression in placenta, liver, kidney, heart and brain.

Evidence on tissue expression from TISSUES for ARMC10 Gene

  • Liver(4.2)
  • Eye(4.1)
  • Nervous system(2.5)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with ARMC10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARMC10 Gene

Orthologs for ARMC10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ARMC10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARMC10 33 34
  • 99.42 (n)
(Canis familiaris)
Mammalia ARMC10 33 34
  • 85.84 (n)
(Bos Taurus)
Mammalia ARMC10 33 34
  • 84.58 (n)
(Mus musculus)
Mammalia Armc10 33 16 34
  • 81.26 (n)
(Rattus norvegicus)
Mammalia Armc10 33
  • 80.83 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 53 (a)
(Monodelphis domestica)
Mammalia ARMC10 34
  • 52 (a)
(Gallus gallus)
Aves ARMC10 33
  • 60.93 (n)
-- 34
  • 43 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia armc10 33
  • 54.7 (n)
(Danio rerio)
Actinopterygii LOC557740 33
  • 47.63 (n)
  • 31 (a)
Species where no ortholog for ARMC10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARMC10 Gene

Gene Tree for ARMC10 (if available)
Gene Tree for ARMC10 (if available)

Paralogs for ARMC10 Gene

Paralogs for ARMC10 Gene

(4) SIMAP similar genes for ARMC10 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ARMC10: view

Variants for ARMC10 Gene

Sequence variations from dbSNP and Humsavar for ARMC10 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000349097 -- 103,075,119(+) TTTCC(A/G)GGAGG upstream-variant-2KB, utr-variant-5-prime
rs1000421039 -- 103,075,219(+) GCTGG(A/C)CCCCG upstream-variant-2KB, utr-variant-5-prime
rs1000483619 -- 103,096,998(+) CAATA(C/T)TCTCT intron-variant
rs1000496598 -- 103,073,466(+) TGGCA(A/G)ACCAA intron-variant, upstream-variant-2KB
rs1000605143 -- 103,096,634(+) GTGCA(A/G)TGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARMC10 Gene

Variant ID Type Subtype PubMed ID
nsv981565 CNV duplication 23825009
nsv526764 CNV loss 19592680
esv3614369 CNV loss 21293372
esv3614368 CNV loss 21293372
esv2752138 CNV loss 17911159
esv2674575 CNV deletion 23128226

Variation tolerance for ARMC10 Gene

Residual Variation Intolerance Score: 73.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.69; 66.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARMC10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARMC10 Gene

Disorders for ARMC10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ARMC10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
lateral medullary syndrome
  • posterior inferior cerebellar artery syndrome
cloacogenic carcinoma
  • cloacogenic anal carcinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ARMC10

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ARMC10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARMC10 Gene

Publications for ARMC10 Gene

  1. A specific splicing variant of SVH, a novel human armadillo repeat protein, is up-regulated in hepatocellular carcinomas. (PMID: 12839973) Huang R … Hu G (Cancer research 2003) 2 3 4 22 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  4. SVH-B interacts directly with p53 and suppresses the transcriptional activity of p53. (PMID: 17904127) Zhou X … Hu G (FEBS letters 2007) 3 4 60
  5. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 60

Products for ARMC10 Gene

Sources for ARMC10 Gene

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