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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ARMC10 Gene

protein-coding GIFtS: 48
GCID: GC07P102715

armadillo repeat containing 10

Explore 6 diseases affiliated with
ARMC10 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Armadillo Repeat Containing 10¹ ²		PNAS-112²
SVH¹ ² ³ ⁵		PNAS112²
Splicing Variant Involved In Hepatocarcinogenesis Protein² ³		Armadillo Repeat-Containing Protein 10²
MGC3195¹		Specific Splicing Variant Involved In Hepatocarcinogenesis²

External Ids:	HGNC: 21706¹	Entrez Gene: 83787²	Ensembl: ENSG00000170632⁷	OMIM: 611864⁵	UniProtKB: Q8N2F6³

Export aliases for ARMC10 gene to outside databases

Previous GC identifers: GC07P102503 GC07P097078

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARMC10:

This gene encodes a protein that contains an armadillo repeat and transmembrane domain. The encoded protein decreases

the transcriptional activity of the tumor suppressor protein p53 through direct interaction with the DNA-binding

domain of p53, and may play a role in cell growth and survival. Upregulation of this gene may play a role in

hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for

this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. (provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: ARM10_HUMAN, Q8N2F6

Function: May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ARMC10 gene promoter:
AREB6 IRF-2 PPAR-gamma1 Tal-1 AML1a Nkx2-2 FOXD1 PPAR-gamma2 LyF-1 E47
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ARMC10 promoter sequence

Search SABiosciences Chromatin IP Primers for ARMC10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARMC10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22.1

ARMC10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARMC10 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P102715: view genomic region (about GC identifiers)

Start:	102,715,328 bp from pter	End:	102,740,205 bp from pter
Size:	24,878 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 102,075,694-102,100,571

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ARM10_HUMAN, Q8N2F6 (See protein sequence)

Recommended Name: Armadillo repeat-containing protein 10

Size: 343 amino acids; 37540 Da

Subunit: Interacts with the DNA-binding domain of p53/TP53

Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein

Miscellaneous: Depletion of isoform 2 results in cell apoptosis while its overexpression in cells leads to accelerated

growth rate and tumorogenicity

Sequence caution: Sequence=AAS07482.1; Type=Erroneous gene model prediction;

Secondary accessions: A8K703 B4DWJ8 Q75K91 Q75MG6 Q75ML8 Q8IZC1 Q8IZC2 Q8IZC3 Q9BTM6

Alternative splicing: 5 isoforms: Q8N2F6-1 Q8N2F6-2 Q8N2F6-3 Q8N2F6-4 Q8N2F6-5 (No experimental confirmation available. Contains a phosphoserine at position 45. Contains a phosphothreonine at position 50)

Explore the universe of human proteins at neXtProt for ARMC10: NX_Q8N2F6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N2F6

ARMC10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_001154481.1 NP_001154482.1 NP_001154483.1 NP_001154484.1 NP_001154485.1 NP_114111.2

ENSEMBL proteins:

ENSP00000319412 ENSP00000396654 ENSP00000413619 ENSP00000405612 ENSP00000319798

ENSP00000305395 ENSP00000398201 ENSP00000406840 ENSP00000397969 ENSP00000440463

Human Recombinant Protein Products for ARMC10:

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	Uscn Proteins for ARMC10

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

ARMC10 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ARMC10 for domains About GeneDecksing

3 InterPro domains/families:

IPR006911 ARM-rpt_dom

IPR011989 ARM-like

IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry Q8N2F6

ProtoNet protein and cluster: Q8N2F6

UniProtKB/Swiss-Prot: ARM10_HUMAN, Q8N2F6

Similarity: Contains 1 ARM repeat

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ARM10_HUMAN, Q8N2F6

Function: May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ARMC10

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARMC10

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ARMC10

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

3 Interacting proteins for ARMC10 (Q8N2F6³ ENSP00000319412⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MME	P08473³	I2D: score=2
YWHAB	P31946³	I2D: score=1
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0040008	regulation of growth	IEA	--

ARMC10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ARMC10
Search CenterWatch for drugs/clinical trials and news about ARMC10 / ARM10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ARMC10 gene (6 alternative transcripts):

NM_001161009.2 NM_001161010.2 NM_001161011.2 NM_001161012.2 NM_001161013.2 NM_031905.4

Unigene Cluster for ARMC10:

Armadillo repeat containing 10

Hs.287412 [show with all ESTs]

Unigene Representative Sequence: NM_031905

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000323716(uc003vaw.2 uc003vay.2) ENST00000428183 ENST00000441711(uc003vax.2 uc011kli.2)

ENST00000454559(uc003vbb.2 uc010lis.2) ENST00000323735 ENST00000306450

ENST00000434153 ENST00000431642 ENST00000479145 ENST00000425331 ENST00000541300

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		6 QIAGEN miScript miRNA Assays for microRNAs that regulate ARMC10:
		hsa-miR-569 hsa-miR-3152-3p hsa-miR-561 hsa-miR-3148 hsa-miR-626 hsa-miR-452
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Additional cDNA sequence:

AF275808.1 AK075500.1 AK225082.1 AK291818.1 AK301565.1 AY150851.1 AY150852.1 AY150853.1

AY150854.1 BC003586.1

18 DOTS entries:

DT.99983730 DT.91756103 DT.100037463 DT.100037467 DT.121073730 DT.100819464 DT.95173889 DT.112333

DT.100819466 DT.100773669 DT.100819467 DT.100037468 DT.100819472 DT.120862279 DT.121073866 DT.121073875

DT.40125676 DT.100819469

24/195 AceView cDNA sequences (see all 195):

BI857038 BE018251 CR618507 CR591473 AL521585 BQ050556 AW875728 AW875869

BU169749 N92228 BM817562 BE018015 BM763136 BE887432 BM683212 CR613957

CD674017 CA396755 BM966819 CR603265 BE886952 CR620954 CR613788 AW875729

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ARMC10 (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8	^	9a	·	9b	·	9c
SP1:											-				-						-
SP2:															-
SP3:															-						-		-		-
SP4:															-						-
SP5:											-				-						-		-		-

ECgene alternative splicing isoforms for ARMC10

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ARMC10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGCAGAGGT

About this image
See ARMC10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARMC10

SOURCE GeneReport for Unigene cluster: Hs.287412

UniProtKB/Swiss-Prot: ARM10_HUMAN, Q8N2F6

Tissue specificity: Expressed in all tissues tested with higher expression in placenta, liver, kidney, heart and brain

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ARMC10 gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
chicken (Gallus gallus)	Aves	ARMC10¹	armadillo repeat containing 10	60.76(n) 45.82(a)	417720 XM_415964.3 XP_415964.3
tropical clawed frog (Xenopus tropicalis)	Amphibia	142013089²	--	72.54(n)	142013089
zebrafish (Danio rerio)	Actinopterygii	LOC557740¹	uncharacterized LOC557740	46.08(n) 35.11(a)	557740 XM_002666841.2 XP_002666887.2

ENSEMBL Gene Tree for ARMC10 (if available)
TreeFam Gene Tree for ARMC10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ARMC10 gene

ARMCX4² GPRASP2² ARMCX1² BHLHB9² ARMCX2² GPRASP1² ARMCX5² ARMCX6²

ARMCX3²

4 SIMAP similar genes for ARMC10 using alignment to 6 protein entries: ARM10_HUMAN (see all proteins):

ARMCX4 ARMCX1 DKFZp686P06199 ARMCX3

ARMC10 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1524419^1,2	C,A	--	97082876(-)	`CTGCAA/GGTTTT`	6	--	int¹		3		NA WA	122
rs73192045^1,2	C,F	--	102073742(+)	`CCAGAC/TGAAGT`	6	--	us2k¹		2		NA EA	240
rs73410133^1,2	C	--	102073928(+)	`GTTAGA/GATTCT`	6	--	us2k¹		2		WA	120
rs74542047^1,2	F	--	102074035(+)	`CACATA/GTATGT`	6	--	us2k¹		1		WA	118
rs74927973^1,2		--	102074076(+)	`CAAATA/GGACAG`	6	--	us2k¹		0	--	--	--	--
rs56703899^1,2	C	--	102074097(+)	`ATGGAC/AAGTTG`	6	--	us2k¹		2		WA	120
rs11976834^1,2	C,F,A,H	--	102075004(+)	`CCCTCC/AGCTAA`	6	--	us2k¹ trp³		16		NS EA NA WA	1724
rs7797873^1,2	C,F	--	102075716(+)	`TGCCAG/CGGGCG`	6	--	ut5¹ ese³		2		WA NA	238
rs111229327^1,2	C	--	102075984(+)	`GTGGCG/TTTTGC`	6	--	ut5¹		1		NA	2
rs62482903^1,2	C	--	102076781(+)	`AAAAGT/CTGATC`	6	--	int¹		2		NA	122

HapMap Linkage Disequilibrium report for ARMC10 (102715328 - 102740205 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ARMC10
2 CNVs: 9065 39503

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARMC10

DNA2.0 Custom Variant and Variant Library Synthesis for ARMC10

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ARMC10 for disorders           About GeneDecksing

OMIM gene information: 611864    OMIM disorders: --

6 diseases for ARMC10:    About MalaCards

hepatocellular carcinoma carcinoma cloacogenic carcinoma meniere's disease

menieres disease otosclerosis

Human Genome Epidemiology (HuGE) Navigator: ARMC10 (2 documents)

Export disorders for ARMC10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ARMC10 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with ARMC10)

Utopia: connect your pdf to the dynamic
world of online information

A specific splicing variant of SVH, a novel human armadillo repeat protein, is up-regulated in hepatocellular carcinomas. (PubMed id 12839973)^{1, 2, 3, 9} Huang R.... Hu G. (2003)
SVH-B interacts directly with p53 and suppresses the transcriptional activity of p53. (PubMed id 17904127)^{1, 2} Zhou X.... Hu G. (2007)
Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)^{1, 2} Otsuki T....Isogai T. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 83787	HGNC: 21706	AceView: SVH	Ensembl:ENSG00000170632	euGenes: HUgn83787
ECgene: ARMC10	H-InvDB: ARMC10

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ARMC10	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ARMC10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ARMC10 gene:
Search GeneIP for patents involving ARMC10

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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ARMC10 Gene

armadillo repeat containing 10

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ARMC10 Gene

armadillo repeat containing 10

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