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Aliases for ARL9 Gene

Aliases for ARL9 Gene

  • ADP Ribosylation Factor Like GTPase 9 2 3 5
  • ADP-Ribosylation Factor Like GTPase 9 2

External Ids for ARL9 Gene

Previous GeneCards Identifiers for ARL9 Gene

  • GC00U914119
  • GC04P057287
  • GC04P057212
  • GC04P057066
  • GC04P057371
  • GC04P053325

Summaries for ARL9 Gene

Entrez Gene Summary for ARL9 Gene

  • ARL9 is a member of the small GTPase protein family with a high degree of similarity to ARF (MIM 103180) proteins of the RAS superfamily.[supplied by OMIM, Nov 2008]

GeneCards Summary for ARL9 Gene

ARL9 (ADP Ribosylation Factor Like GTPase 9) is a Protein Coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is ARL10.

Additional gene information for ARL9 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL9 Gene

Genomics for ARL9 Gene

Regulatory Elements for ARL9 Gene

Enhancers for ARL9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H056530 0.8 ENCODE 19.1 +25.8 25761 0.8 TBP BMI1 BRCA1 EGR1 SCRT2 ZHX1 SP3 SMAD5 REST SP1 SRP72 ARL9 THEGL ENSG00000251799 SPINK2 GLDCP1
GH04H056459 0.7 dbSUPER 20.1 -44.9 -44886 1.6 PAF1 CEBPB ZEB2 CEBPG ZBTB40 ZNF518A POLR2A ZSCAN5C SCRT2 ZNF24 ARL9 SRP72 PAICS PPAT AASDH ENSG00000251799 SPINK2 GC04P056465 GC04P056436 GC04P056437
GH04H056465 1.3 ENCODE dbSUPER 8.1 -38.1 -38059 4.3 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 YY1 FOS SP3 SP5 SRP72 AASDH PAICS PPAT SPINK2 ENSG00000251799 ARL9 GC04M056462
GH04H056433 1.1 ENCODE 7.7 -69.3 -69347 4.8 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 SRP72 AASDH CEP135 RN7SKP30 POLR2B ENSG00000269921 ARL9 PAICS GC04P056437 GC04P056436
GH04H056544 1.3 Ensembl ENCODE 5.8 +39.6 39586 1.2 ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 SP3 MXD4 REST SMARCB1 ENSG00000251799 SPINK2 AASDH ARL9 THEGL GLDCP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARL9 on UCSC Golden Path with GeneCards custom track

Promoters for ARL9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000168662 491 1001 ZNF687 MAX ZBTB33 PRDM1 EZH2

Genomic Locations for ARL9 Gene

Genomic Locations for ARL9 Gene
19,240 bases
Plus strand

Genomic View for ARL9 Gene

Genes around ARL9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL9 Gene

Proteins for ARL9 Gene

  • Protein details for ARL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP-ribosylation factor-like protein 9
    Protein Accession:

    Protein attributes for ARL9 Gene

    187 amino acids
    Molecular mass:
    20755 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ARL9 Gene


neXtProt entry for ARL9 Gene

Post-translational modifications for ARL9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARL9 Gene

No data available for DME Specific Peptides for ARL9 Gene

Domains & Families for ARL9 Gene

Gene Families for ARL9 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARL9 Gene

Suggested Antigen Peptide Sequences for ARL9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Arf family.
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL9: view

Function for ARL9 Gene

Phenotypes From GWAS Catalog for ARL9 Gene

Gene Ontology (GO) - Molecular Function for ARL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with ARL9: view
genes like me logo Genes that share phenotypes with ARL9: view

Animal Models for ARL9 Gene

MGI Knock Outs for ARL9:
  • Arl9 tm1.1(KOMP)Vlcg

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARL9 Gene

Localization for ARL9 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL9 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with ARL9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARL9 Gene

Pathways & Interactions for ARL9 Gene

No Data Available

Interacting Proteins for ARL9 Gene

Gene Ontology (GO) - Biological Process for ARL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with ARL9: view

No data available for Pathways by source and SIGNOR curated interactions for ARL9 Gene

Drugs & Compounds for ARL9 Gene

No Compound Related Data Available

Transcripts for ARL9 Gene

mRNA/cDNA for ARL9 Gene

Unigene Clusters for ARL9 Gene

ADP-ribosylation factor-like 9:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL9 Gene

No ASD Table

Relevant External Links for ARL9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARL9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARL9 Gene

mRNA differential expression in normal tissues according to GTEx for ARL9 Gene

This gene is overexpressed in Testis (x10.4).

NURSA nuclear receptor signaling pathways regulating expression of ARL9 Gene:


SOURCE GeneReport for Unigene cluster for ARL9 Gene:

genes like me logo Genes that share expression patterns with ARL9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL9 Gene

Orthologs for ARL9 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARL9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARL9 33 34
  • 99.46 (n)
(Canis familiaris)
Mammalia ARL9 33 34
  • 90.24 (n)
(Bos Taurus)
Mammalia ARL9 33 34
  • 89.89 (n)
(Mus musculus)
Mammalia Arl9 33 16 34
  • 86.98 (n)
(Rattus norvegicus)
Mammalia Arl9 33
  • 83.61 (n)
(Monodelphis domestica)
Mammalia ARL9 34
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia ARL9 34
  • 40 (a)
(Gallus gallus)
Aves ARL9 33 34
  • 71.82 (n)
(Anolis carolinensis)
Reptilia ARL9 34
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arl9 33
  • 63.66 (n)
Str.15113 33
(Danio rerio)
Actinopterygii arl9 33 34
  • 55.65 (n)
fruit fly
(Drosophila melanogaster)
Insecta Gie 34
  • 18 (a)
(Caenorhabditis elegans)
Secernentea arl-8 34
  • 19 (a)
Species where no ortholog for ARL9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARL9 Gene

Gene Tree for ARL9 (if available)
Gene Tree for ARL9 (if available)

Paralogs for ARL9 Gene

Paralogs for ARL9 Gene

(19) SIMAP similar genes for ARL9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARL9: view

Variants for ARL9 Gene

Sequence variations from dbSNP and Humsavar for ARL9 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs192226722 Likely benign 56,503,625(+) TATGG(A/G)TACAT upstream-variant-2KB, utr-variant-3-prime
rs886059503 Uncertain significance 56,503,539(+) TTCCT(C/T)TTTTG upstream-variant-2KB, utr-variant-3-prime
rs886059504 Uncertain significance 56,503,630(+) ATACA(G/T)CCATT upstream-variant-2KB, utr-variant-3-prime
rs1142851 Benign 56,503,464(+) CAACT(A/G)AAACT upstream-variant-2KB, utr-variant-3-prime
rs1000146355 -- 56,518,944(+) ATGCT(A/G)TATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARL9 Gene

Variant ID Type Subtype PubMed ID
nsv829941 CNV loss 17160897
nsv1161086 CNV duplication 26073780
esv3600576 CNV loss 21293372
esv2657721 CNV deletion 23128226
dgv5213n100 CNV gain 25217958

Variation tolerance for ARL9 Gene

Residual Variation Intolerance Score: 75.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARL9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL9 Gene

Disorders for ARL9 Gene

Relevant External Links for ARL9

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARL9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL9 Gene

Publications for ARL9 Gene

  1. RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors. (PMID: 15033445) Louro R … Reis EM (Biochemical and biophysical research communications 2004) 3 4 60
  2. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H … Espeseth AS (Cell host & microbe 2008) 3 60
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 60
  4. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh JH … Kim NS (Mammalian genome : official journal of the International Mammalian Genome Society 2005) 4 60

Products for ARL9 Gene

Sources for ARL9 Gene

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