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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARL9 Gene

protein-coding   GIFtS: 40
GCID: GC04P057371

ADP-Ribosylation Factor-Like 9

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ADP-Ribosylation Factor-Like 91 2
ADP-Ribosylation Factor-Like Protein 92

External Ids:    HGNC: 235921   Entrez Gene: 1329462   Ensembl: ENSG000001965037   OMIM: 6124055   UniProtKB: Q6T3113   

Export aliases for ARL9 gene to outside databases

Previous GC identifers: GC00U914119 GC04P057287 GC04P057212 GC04P057066 GC04P053325


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARL9 Gene:
ARL9 is a member of the small GTPase protein family with a high degree of similarity to ARF (MIM 103180) proteins
of the RAS superfamily.(supplied by OMIM, Nov 2008)

GeneCards Summary for ARL9 Gene: 
ARL9 (ADP-ribosylation factor-like 9) is a protein-coding gene. Diseases associated with ARL9 include prostatitis. GO annotations related to this gene include GTP binding. An important paralog of this gene is ARL15.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_022853.15  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARL9 gene promoter:
         E2F-3a   E2F-4   E2F-5   AP-4   E2F-2   RORalpha2   YY1   E2F-1   E2F   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARL9 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARL9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12   Ensembl cytogenetic band:  4q12   HGNC cytogenetic band: 4q12

ARL9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL9 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P057371:  view genomic region     (about GC identifiers)

Start:
57,371,375 bp from pter      End:
57,390,614 bp from pter
Size:
19,240 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARL9_HUMAN, Q6T311 (See protein sequence)
Recommended Name: ADP-ribosylation factor-like protein 9  
Size: 187 amino acids; 20755 Da

Explore the universe of human proteins at neXtProt for ARL9: NX_Q6T311

Explore proteomics data for ARL9 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6T311

  • ARL9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARL9 Protein Expression
    REFSEQ proteins: NP_996802.1  
    ENSEMBL proteins: 
     ENSP00000353210  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--

    ARL9 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ARL: ADP-ribosylation factors-like

    4 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF
     IPR005225 Small_GTP-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q6T311

    ProtoNet protein and cluster: Q6T311

    UniProtKB/Swiss-Prot: ARL9_HUMAN, Q6T311
    Similarity: Belongs to the small GTPase superfamily. Arf family


    ARL9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005525GTP binding IEA--
         
    ARL9 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARL9

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264small GTPase mediated signal transduction IEA--

    ARL9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARL9

    Search CenterWatch for drugs/clinical trials and news about ARL9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for ARL9 gene: 
    NM_206919.1  

    Unigene Cluster for ARL9:

    ADP-ribosylation factor-like 9
    Hs.444449  [show with all ESTs]
    Unigene Representative Sequence: AY439003
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000360096(uc003hby.1)
    miRNA
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    Additional mRNA sequence: AY439003.1 

    2 DOTS entries:

    DT.100734466  DT.92068835 

    24/32 AceView cDNA sequences (see all 32):

    BU101774 AA425698 AW594395 AY439003 AA234274 BX103554 NM_206919 BE463997 
    BM854066 BE552080 CB123729 AA428548 N78781 AI656595 AI150007 BF059732 
    AW207074 AA620971 AI992069 AA927415 AA778704 AI686633 AI208738 AI377529 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARL9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ARL9 Expression
    About this image


    See ARL9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARL9

    SOURCE GeneReport for Unigene cluster: Hs.444449
        SABiosciences Custom PCR Arrays for ARL9
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ARL9 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arl91 , 5 ADP-ribosylation factor-like 91, 5 86.98(n)1
    89.06(a)1
      5 (41.45 cM)5
    3841851  NM_206935.11  NP_996818.11 
     770040555 
    chicken
    (Gallus gallus)
    Aves ARL91 ADP-ribosylation factor-like 9 71.82(n)
    67.48(a)
      771078  XM_001234379.2  XP_001234380.2 
    lizard
    (Anolis carolinensis)
    Reptilia ARL96
    Uncharacterized protein
    43(a)
    1 ↔ 1
    GL343257.1(1708844-1713601)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.151132 Transcribed sequence with weak similarity to protein more 70.74(n)    142031563 
    zebrafish
    (Danio rerio)
    Actinopterygii arl91 ADP-ribosylation factor-like 9 55.65(n)
    52.07(a)
      751670  NM_001045387.1  NP_001038852.1 


    ENSEMBL Gene Tree for ARL9 (if available)
    TreeFam Gene Tree for ARL9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARL9 gene
    ARL152  ARL22  ARL32  ARL102  
    18/19 SIMAP similar genes for ARL9 using alignment to 1 protein entry:     ARL9_HUMAN(see all similar genes):
    ARL2    ARL3    ARL5B    ARL10    ARF3    ARF1
    ARL14    ARF6    ARF5    ARL13B    ARF4    ARL1
    ARL5A    ARL4C    ARL7    ARL4D    ARL6    ARL8A

    ARL9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/440 SNPs in ARL9 are shown (see all 440)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1928220201,2
    C--57370388(+) GCTACA/GTGCGA 1 -- us2k10--------
    rs48651081,2
    C,F--57370474(+) CCTGGG/ACAACA 1 -- us2k14Minor allele frequency- A:0.25NA WA 8
    rs1830472701,2
    --57370493(+) ACTCCA/GTCTCA 1 -- us2k10--------
    rs1386713391,2
    C--57370501(+) ATAAT-/AATTGTGC 1 -- cds10--------
    rs1871353281,2
    --57370518(+) TGGACA/GGGTGC 1 -- us2k10--------
    rs100020451,2
    C,F--57370566(+) ccaatC/Taggcg 1 -- us2k11Minor allele frequency- T:0.11WA 118
    rs1497736691,2
    --57370617(+) ATGGTA/GAAACT 1 -- us2k10--------
    rs1919008041,2
    --57370721(+) AACCCA/GGGAGG 1 -- us2k10--------
    rs585917201,2
    C--57370776(+) GGCCGA/CCAGAG 1 -- us2k10--------
    rs1489028631,2
    --57370892(+) GAAACA/GATACC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARL9 (57371375 - 57390614 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ARL9:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2657721CNV Deletion23128226
    nsv829941CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612405    OMIM disorders: --

    2 diseases for ARL9:    About MalaCards
    prostatitis    


    ARL9 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARL9

    Export disorders for ARL9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed article for ARL9 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ARL9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Rasl11a, member of a novel small monomeric GTPase gene family, is differentially expressed in prostate tumors. (PubMed id 15033445)1, 2 Louro R.... Reis E.M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 132946 HGNC: 23592 AceView: ARL9 Ensembl:ENSG00000196503 euGenes: HUgn132946
    ECgene: ARL9 H-InvDB: ARL9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARL9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARL9 gene:
    Search GeneIP for patents involving ARL9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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