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ARL9 Gene

protein-coding   GIFtS: 42
GCID: GC04P057371

ADP-Ribosylation Factor-Like 9

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADP-Ribosylation Factor-Like 91 2
ADP-Ribosylation Factor-Like Protein 92

External Ids:    HGNC: 235921   Entrez Gene: 1329462   Ensembl: ENSG000001965037   OMIM: 6124055   UniProtKB: Q6T3113   

Export aliases for ARL9 gene to outside databases

Previous GC identifers: GC00U914119 GC04P057287 GC04P057212 GC04P057066 GC04P053325


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARL9 Gene:
ARL9 is a member of the small GTPase protein family with a high degree of similarity to ARF (MIM 103180) proteins
of the RAS superfamily.(supplied by OMIM, Nov 2008)

GeneCards Summary for ARL9 Gene:
ARL9 (ADP-ribosylation factor-like 9) is a protein-coding gene. Diseases associated with ARL9 include prostatitis. GO annotations related to this gene include GTP binding. An important paralog of this gene is ARL15.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_022853.16  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARL9 gene promoter:
         E2F-3a   E2F-4   E2F-5   AP-4   E2F-2   RORalpha2   YY1   E2F-1   E2F   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARL9 promoter sequence
   Search Chromatin IP Primers for ARL9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARL9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12   Ensembl cytogenetic band:  4q12   HGNC cytogenetic band: 4q12

ARL9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL9 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P057371:  view genomic region     (about GC identifiers)

Start:
57,371,375 bp from pter      End:
57,390,614 bp from pter
Size:
19,240 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARL9_HUMAN, Q6T311 (See protein sequence)
Recommended Name: ADP-ribosylation factor-like protein 9  
Size: 187 amino acids; 20755 Da

Explore the universe of human proteins at neXtProt for ARL9: NX_Q6T311

Explore proteomics data for ARL9 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARL9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_996802.1  
    ENSEMBL proteins: 
     ENSP00000353210  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARL: ADP-ribosylation factors-like
    ARF: ADP-ribosylation factors

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR027417 P-loop_NTPase
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF

    Graphical View of Domain Structure for InterPro Entry Q6T311

    ProtoNet protein and cluster: Q6T311

    UniProtKB/Swiss-Prot: ARL9_HUMAN, Q6T311
    Similarity: Belongs to the small GTPase superfamily. Arf family


    ARL9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005525GTP binding IEA--
         
    ARL9 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--

    ARL9 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARL9
    Interactions:

        Search GeneGlobe Interaction Network for ARL9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for ARL9 (ENSP000003532104) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIGTENSP000002790364STRING: ENSP00000279036
    POLR3EENSP000002998534STRING: ENSP00000299853
    STX16ENSP000003601834STRING: ENSP00000360183
    GBF1ENSP000003590004STRING: ENSP00000359000
    CLTCENSP000002691224STRING: ENSP00000269122
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264small GTPase mediated signal transduction IEA--

    ARL9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARL9



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARL9 gene: 
    NM_206919.1  

    Unigene Cluster for ARL9:

    ADP-ribosylation factor-like 9
    Hs.444449  [show with all ESTs]
    Unigene Representative Sequence: AY439003
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000360096(uc003hby.1)
    miRNA
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    Additional mRNA sequence: AY439003.1 

    2 DOTS entries:

    DT.100734466  DT.92068835 

    Selected AceView cDNA sequences (see all 32):

    BE463997 AW594395 AA425698 BM854066 BX103554 NM_206919 AA234274 AY439003 
    BU101774 AA927415 AI992069 CB123729 AA778704 AI656595 BE552080 BF059732 
    N78781 AA428548 AW207074 AA620971 AI150007 AI377529 AW204927 BM930307 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARL9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ARL9 Expression
    About this image

    ARL9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARL9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.444449
        Custom PCR Arrays for ARL9
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARL9 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arl91 , 5 ADP-ribosylation factor-like 91, 5 86.98(n)1
    89.06(a)1
      5 (41.45 cM)5
    3841851  NM_206935.11  NP_996818.11 
     770040555 
    chicken
    (Gallus gallus)
    Aves ARL91 ADP-ribosylation factor-like 9 71.82(n)
    67.48(a)
      771078  XM_001234379.3  XP_001234380.3 
    lizard
    (Anolis carolinensis)
    Reptilia ARL96
    ADP-ribosylation factor-like 9
    43(a)
    1 ↔ 1
    GL343257.1(1708844-1713601)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.151132 Transcribed sequence with weak similarity to protein more 70.74(n)    142031563 
    zebrafish
    (Danio rerio)
    Actinopterygii arl91 ADP-ribosylation factor-like 9 55.65(n)
    52.07(a)
      751670  NM_001045387.1  NP_001038852.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gie6
    GTPase indispensable for equal segregation of chro...
    18(a)
    1 → many
    3R(3952336-3954568)
    worm
    (Caenorhabditis elegans)
    Secernentea arl-86
    Protein ARL-8 (arl-8) mRNA, complete cds
    19(a)
    1 → many
    IV(14798149-14799310) WBGene00000192


    ENSEMBL Gene Tree for ARL9 (if available)
    TreeFam Gene Tree for ARL9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARL9 gene
    ARL152  ARL62  ARL8A2  ARL8B2  ARL102  ARL12  
    Selected SIMAP similar genes for ARL9 using alignment to 1 protein entry:     ARL9_HUMAN(see all similar genes):
    ARL2    ARL3    ARL5B    ARL10    ARF1    ARF3
    ARL14    ARF6    ARF5    ARL13B    ARF4    ARL1
    ARL5A    ARL4C    ARL7    ARL4D    ARL6    ARL8A

    ARL9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARL9 (see all 440)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1928220201,2
    C--57370388(+) GCTACA/GTGCGA 1 -- us2k10--------
    rs48651081,2
    C,F--57370474(+) CCTGGG/ACAACA 1 -- us2k14Minor allele frequency- A:0.25NA WA 8
    rs1830472701,2
    --57370493(+) ACTCCA/GTCTCA 1 -- us2k10--------
    rs1386713391,2
    C--57370501(+) ATAAT-/AATTGTGC 1 -- cds10--------
    rs1871353281,2
    --57370518(+) TGGACA/GGGTGC 1 -- us2k10--------
    rs100020451,2
    C,F--57370566(+) ccaatC/Taggcg 1 -- us2k11Minor allele frequency- T:0.11WA 118
    rs1497736691,2
    --57370617(+) ATGGTA/GAAACT 1 -- us2k10--------
    rs1919008041,2
    --57370721(+) AACCCA/GGGAGG 1 -- us2k10--------
    rs585917201,2
    C--57370776(+) GGCCGA/CCAGAG 1 -- us2k10--------
    rs1489028631,2
    --57370892(+) GAAACA/GATACC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARL9 (57371375 - 57390614 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ARL9:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2657721CNV Deletion23128226
    nsv829941CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARL9
    DNA2.0 Custom Variant and Variant Library Synthesis for ARL9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612405    OMIM disorders: --

    1 disease for ARL9:    
    About MalaCards
    prostatitis


    ARL9 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARL9

    Export disorders for ARL9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARL9 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ARL9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Rasl11a, member of a novel small monomeric GTPase gene family, is differentially expressed in prostate tumors. (PubMed id 15033445)1, 2 Louro R.... Reis E.M. (Biochem. Biophys. Res. Commun. 2004)
    2. Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)1 Zhou H....Espeseth A.S. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 132946 HGNC: 23592 AceView: ARL9 Ensembl:ENSG00000196503 euGenes: HUgn132946
    ECgene: ARL9 H-InvDB: ARL9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARL9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARL9 gene:
    Search GeneIP for patents involving ARL9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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