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Aliases for ARL8B Gene

Aliases for ARL8B Gene

  • ADP Ribosylation Factor Like GTPase 8B 2 3 5
  • Novel Small G Protein Indispensable For Equal Chromosome Segregation 1 3 4
  • ADP-Ribosylation Factor-Like Protein 10C 3 4
  • ADP-Ribosylation Factor-Like 10C 2 3
  • ADP-Ribosylation Factor-Like 8B 2 3
  • ARL10C 3 4
  • Gie1 3 4
  • ADP-Ribosylation Factor-Like Protein 8B 3

External Ids for ARL8B Gene

Previous HGNC Symbols for ARL8B Gene

  • ARL10C

Previous GeneCards Identifiers for ARL8B Gene

  • GC03P005139
  • GC03P005163
  • GC03P005096

Summaries for ARL8B Gene

GeneCards Summary for ARL8B Gene

ARL8B (ADP Ribosylation Factor Like GTPase 8B) is a Protein Coding gene. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is ARL8A.

UniProtKB/Swiss-Prot for ARL8B Gene

  • May play a role in lysosome motility (PubMed:16537643, PubMed:25898167). May play a role in chromosome segregation (PubMed:15331635).

Gene Wiki entry for ARL8B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL8B Gene

Genomics for ARL8B Gene

Regulatory Elements for ARL8B Gene

Enhancers for ARL8B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F005180 1.8 FANTOM5 Ensembl ENCODE 34.5 +68.4 68418 20.6 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ARL8B EDEM1 BHLHE40 ENSG00000268509 PIR54874
GH03F005136 1.6 FANTOM5 Ensembl ENCODE 33.7 +16.6 16582 5.2 HDGF PKNOX1 FEZF1 ZNF121 FOS PPARG TBX21 KAT8 SSRP1 ZNF585B ARL8B EDEM1 ENSG00000233912 BHLHE40
GH03F004866 1.8 FANTOM5 Ensembl ENCODE 28.4 -254.1 -254071 4.0 HDGF PKNOX1 CREB3L1 SIN3A FEZF1 YY1 CBX5 ZNF143 FOS KLF13 ARL8B EGOT BHLHE40 EDEM1 ITPR1 ENSG00000235978
GH03F004717 1.7 FANTOM5 Ensembl ENCODE 21.7 -400.9 -400864 6.9 HDGF PKNOX1 ATF1 ARNT MLX ARID4B SIN3A ZNF48 YY1 ZNF766 ARL8B BHLHE40 EGOT BHLHE40-AS1 ENSG00000235978 EDEM1 ENSG00000275981 LOC105376933
GH03F005009 1.9 FANTOM5 Ensembl ENCODE 17.3 -103.4 -103420 18.4 CREB3L1 MLX ZFP64 DMAP1 FEZF1 YBX1 SLC30A9 ZNF143 ZNF263 SP3 BHLHE40 ARL8B EDEM1 LOC105376934 BHLHE40-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARL8B on UCSC Golden Path with GeneCards custom track

Promoters for ARL8B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001476181 780 2401 HDGF CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143

Genomic Location for ARL8B Gene

Chromosome:
3
Start:
5,122,220 bp from pter
End:
5,180,916 bp from pter
Size:
58,697 bases
Orientation:
Plus strand

Genomic View for ARL8B Gene

Genes around ARL8B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL8B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL8B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL8B Gene

Proteins for ARL8B Gene

  • Protein details for ARL8B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVJ2-ARL8B_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 8B
    Protein Accession:
    Q9NVJ2
    Secondary Accessions:
    • B4DI85

    Protein attributes for ARL8B Gene

    Size:
    186 amino acids
    Molecular mass:
    21539 Da
    Quaternary structure:
    • Interacts with tubulin (PubMed:15331635, Ref.16). Interacts with BORCS5; recruits ARL8B to lysosomes (PubMed:25898167).

    Three dimensional structures from OCA and Proteopedia for ARL8B Gene

    Alternative splice isoforms for ARL8B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARL8B Gene

Post-translational modifications for ARL8B Gene

  • Ubiquitination at Lys 141 and Lys 146
  • Modification sites at PhosphoSitePlus

Other Protein References for ARL8B Gene

No data available for DME Specific Peptides for ARL8B Gene

Domains & Families for ARL8B Gene

Gene Families for ARL8B Gene

Graphical View of Domain Structure for InterPro Entry

Q9NVJ2

UniProtKB/Swiss-Prot:

ARL8B_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL8B: view

Function for ARL8B Gene

Molecular function for ARL8B Gene

UniProtKB/Swiss-Prot Function:
May play a role in lysosome motility (PubMed:16537643, PubMed:25898167). May play a role in chromosome segregation (PubMed:15331635).

Gene Ontology (GO) - Molecular Function for ARL8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 15331635
GO:0005515 protein binding IPI 25898167
GO:0005525 GTP binding IDA 15331635
GO:0019003 GDP binding IDA 15331635
GO:0043014 alpha-tubulin binding IDA 15331635
genes like me logo Genes that share ontologies with ARL8B: view
genes like me logo Genes that share phenotypes with ARL8B: view

Animal Models for ARL8B Gene

MGI Knock Outs for ARL8B:

Animal Model Products

miRNA for ARL8B Gene

miRTarBase miRNAs that target ARL8B

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ARL8B

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARL8B Gene

Localization for ARL8B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL8B Gene

Late endosome membrane. Lysosome membrane. Cytoplasm, cytoskeleton, spindle. Note=Localizes with microtubules at the spindle mid-zone during mitosis. {ECO:0000269 PubMed:15331635}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL8B gene
Compartment Confidence
extracellular 5
cytoskeleton 5
lysosome 4
endosome 4
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ARL8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA,IDA 15331635
GO:0005764 lysosome IEA --
GO:0005765 colocalizes_with lysosomal membrane IEA,IDA 25898167
GO:0005768 endosome IEA --
genes like me logo Genes that share ontologies with ARL8B: view

Pathways & Interactions for ARL8B Gene

SuperPathways for ARL8B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007059 chromosome segregation IMP 14871887
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0032418 lysosome localization IMP 25898167
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with ARL8B: view

No data available for Pathways by source and SIGNOR curated interactions for ARL8B Gene

Transcripts for ARL8B Gene

Unigene Clusters for ARL8B Gene

ADP-ribosylation factor-like 8B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ARL8B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL8B Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b
SP1: - -
SP2: - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - - -
SP6: -
SP7: - - -
SP8: - - - - - -
SP9: -

Relevant External Links for ARL8B Gene

GeneLoc Exon Structure for
ARL8B
ECgene alternative splicing isoforms for
ARL8B

Expression for ARL8B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARL8B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARL8B Gene



Protein tissue co-expression partners for ARL8B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARL8B Gene:

ARL8B

SOURCE GeneReport for Unigene cluster for ARL8B Gene:

Hs.250009

mRNA Expression by UniProt/SwissProt for ARL8B Gene:

Q9NVJ2-ARL8B_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with ARL8B: view

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for ARL8B Gene

Orthologs for ARL8B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARL8B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARL8B 34 35
  • 100 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ARL8B 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARL8B 34 35
  • 96.59 (n)
dog
(Canis familiaris)
Mammalia ARL8B 34 35
  • 96.59 (n)
mouse
(Mus musculus)
Mammalia Arl8b 34 16 35
  • 94.62 (n)
oppossum
(Monodelphis domestica)
Mammalia ARL8B 35
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arl8b 34
  • 93.91 (n)
chicken
(Gallus gallus)
Aves ARL8A 35
  • 98 (a)
OneToOne
ARL8B 34
  • 89.61 (n)
lizard
(Anolis carolinensis)
Reptilia ARL8B 35
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arl8b 34
  • 81.36 (n)
zebrafish
(Danio rerio)
Actinopterygii arl8ba 35
  • 97 (a)
OneToMany
arl8bb 34 35
  • 78.85 (n)
Dr.19764 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5047 34
fruit fly
(Drosophila melanogaster)
Insecta Gie 35
  • 87 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea arl-8 35
  • 85 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ARLA1A 34
  • 62.27 (n)
rice
(Oryza sativa)
Liliopsida Os02g0732500 34
  • 60.87 (n)
Os.9284 34
barley
(Hordeum vulgare)
Liliopsida Hv.9524 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4095 35
  • 85 (a)
OneToOne
Species where no ortholog for ARL8B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARL8B Gene

ENSEMBL:
Gene Tree for ARL8B (if available)
TreeFam:
Gene Tree for ARL8B (if available)

Paralogs for ARL8B Gene

Paralogs for ARL8B Gene

Pseudogenes.org Pseudogenes for ARL8B Gene

genes like me logo Genes that share paralogs with ARL8B: view

Variants for ARL8B Gene

Sequence variations from dbSNP and Humsavar for ARL8B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10428135 -- 5,153,395(+) tctct(A/G)cacaa intron-variant
rs10428151 -- 5,153,970(+) tttga(C/T)tgttt intron-variant
rs10552472 -- 5,173,714(+) TGTCT(-/CAAA)CAAAC intron-variant
rs10575722 -- 5,169,306(+) GTGTT(-/TG)TGTGT intron-variant
rs111243101 -- 5,151,029(+) ATGTC(A/G)GTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARL8B Gene

Variant ID Type Subtype PubMed ID
nsv966985 CNV duplication 23825009
nsv1002376 CNV gain 25217958
esv3595125 CNV loss 21293372
esv3595124 CNV loss 21293372
esv2671785 CNV deletion 23128226
esv2484755 CNV deletion 19546169

Variation tolerance for ARL8B Gene

Residual Variation Intolerance Score: 57.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARL8B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARL8B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL8B Gene

Disorders for ARL8B Gene

Relevant External Links for ARL8B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARL8B

No disorders were found for ARL8B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL8B Gene

Publications for ARL8B Gene

  1. An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility. (PMID: 16537643) Hofmann I. … Munro S. (J. Cell Sci. 2006) 3 4 22 64
  2. Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation. (PMID: 15331635) Okai T. … Katada T. (J. Cell Sci. 2004) 3 4 22 64
  3. BORC, a multisubunit complex that regulates lysosome positioning. (PMID: 25898167) Pu J. … Bonifacino J.S. (Dev. Cell 2015) 3 4 64
  4. Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity. (PMID: 24088571) Tuli A. … Brenner M.B. (Mol. Biol. Cell 2013) 2 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for ARL8B Gene

Sources for ARL8B Gene

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