Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ARL8B Gene

Aliases for ARL8B Gene

  • ADP Ribosylation Factor Like GTPase 8B 2 3 5
  • Novel Small G Protein Indispensable For Equal Chromosome Segregation 1 3 4
  • ADP-Ribosylation Factor-Like Protein 10C 3 4
  • ADP-Ribosylation Factor-Like 10C 2 3
  • ADP-Ribosylation Factor-Like 8B 2 3
  • ARL10C 3 4
  • Gie1 3 4
  • ADP-Ribosylation Factor Like GTPase 8B 3

External Ids for ARL8B Gene

Previous HGNC Symbols for ARL8B Gene

  • ARL10C

Previous GeneCards Identifiers for ARL8B Gene

  • GC03P005139
  • GC03P005163
  • GC03P005096

Summaries for ARL8B Gene

GeneCards Summary for ARL8B Gene

ARL8B (ADP Ribosylation Factor Like GTPase 8B) is a Protein Coding gene. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is ARL1.

UniProtKB/Swiss-Prot for ARL8B Gene

  • May play a role in lysosome motility (PubMed:16537643). May play a role in chromosome segregation (PubMed:15331635).

Gene Wiki entry for ARL8B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL8B Gene

Genomics for ARL8B Gene

Regulatory Elements for ARL8B Gene

Enhancers for ARL8B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARL8B on UCSC Golden Path with GeneCards custom track

Promoters for ARL8B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARL8B on UCSC Golden Path with GeneCards custom track

Genomic Location for ARL8B Gene

5,122,220 bp from pter
5,180,916 bp from pter
58,697 bases
Plus strand

Genomic View for ARL8B Gene

Genes around ARL8B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL8B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL8B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL8B Gene

Proteins for ARL8B Gene

  • Protein details for ARL8B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP-ribosylation factor-like protein 8B
    Protein Accession:
    Secondary Accessions:
    • B4DI85

    Protein attributes for ARL8B Gene

    186 amino acids
    Molecular mass:
    21539 Da
    Quaternary structure:
    • Interacts with tubulin.

    Three dimensional structures from OCA and Proteopedia for ARL8B Gene

    Alternative splice isoforms for ARL8B Gene


neXtProt entry for ARL8B Gene

Proteomics data for ARL8B Gene at MOPED

Post-translational modifications for ARL8B Gene

  • Ubiquitination at Lys 141 and Lys 146
  • Modification sites at PhosphoSitePlus

Other Protein References for ARL8B Gene

No data available for DME Specific Peptides for ARL8B Gene

Domains & Families for ARL8B Gene

Gene Families for ARL8B Gene

Protein Domains for ARL8B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Arf family.
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL8B: view

Function for ARL8B Gene

Molecular function for ARL8B Gene

UniProtKB/Swiss-Prot Function:
May play a role in lysosome motility (PubMed:16537643). May play a role in chromosome segregation (PubMed:15331635).

Phenotypes for ARL8B Gene

GenomeRNAi human phenotypes for ARL8B:
genes like me logo Genes that share phenotypes with ARL8B: view

Animal Model Products

miRNA for ARL8B Gene

miRTarBase miRNAs that target ARL8B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL8B Gene

Localization for ARL8B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL8B Gene

Late endosome membrane. Lysosome membrane. Cytoplasm, cytoskeleton, spindle. Note=According to PubMed:15331635, it localizes with microtubules at the spindle mid-zone during mitosis.

Subcellular locations from

Jensen Localization Image for ARL8B Gene COMPARTMENTS Subcellular localization image for ARL8B gene
Compartment Confidence
cytoskeleton 5
endosome 5
extracellular 5
lysosome 5
vacuole 5
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ARL8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,IDA 19946888
GO:0031902 late endosome membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ARL8B: view

Pathways & Interactions for ARL8B Gene

SuperPathways for ARL8B Gene

No Data Available

Interacting Proteins for ARL8B Gene

Gene Ontology (GO) - Biological Process for ARL8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with ARL8B: view

No data available for Pathways by source and SIGNOR curated interactions for ARL8B Gene

Drugs & Compounds for ARL8B Gene

No Compound Related Data Available

Transcripts for ARL8B Gene

Unigene Clusters for ARL8B Gene

ADP-ribosylation factor-like 8B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARL8B Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b
SP1: - -
SP2: - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - - -
SP6: -
SP7: - - -
SP8: - - - - - -
SP9: -

Relevant External Links for ARL8B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARL8B Gene

mRNA expression in normal human tissues for ARL8B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARL8B Gene

SOURCE GeneReport for Unigene cluster for ARL8B Gene Hs.250009

mRNA Expression by UniProt/SwissProt for ARL8B Gene

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with ARL8B: view

Protein tissue co-expression partners for ARL8B Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for ARL8B Gene

Orthologs for ARL8B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARL8B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARL8B 35
  • 96.59 (n)
  • 99.46 (a)
ARL8B 36
  • 100 (a)
(Canis familiaris)
Mammalia ARL8B 35
  • 96.59 (n)
  • 100 (a)
ARL8B 36
  • 100 (a)
(Mus musculus)
Mammalia Arl8b 35
  • 94.62 (n)
  • 100 (a)
Arl8b 16
Arl8b 36
  • 100 (a)
(Pan troglodytes)
Mammalia ARL8B 35
  • 100 (n)
  • 100 (a)
ARL8B 36
  • 78 (a)
(Rattus norvegicus)
Mammalia Arl8b 35
  • 93.91 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia ARL8B 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia ARL8B 36
  • 100 (a)
(Gallus gallus)
Aves ARL8B 35
  • 89.61 (n)
  • 98.39 (a)
ARL8A 36
  • 98 (a)
(Anolis carolinensis)
Reptilia ARL8B 36
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arl8b 35
  • 81.36 (n)
  • 96.24 (a)
(Danio rerio)
Actinopterygii arl8bb 35
  • 78.85 (n)
  • 94.09 (a)
Dr.19764 35
arl8ba 36
  • 97 (a)
arl8bb 36
  • 90 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5047 35
fruit fly
(Drosophila melanogaster)
Insecta Gie 36
  • 87 (a)
(Caenorhabditis elegans)
Secernentea arl-8 36
  • 85 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ARLA1A 35
  • 62.27 (n)
  • 64.29 (a)
(Hordeum vulgare)
Liliopsida Hv.9524 35
(Oryza sativa)
Liliopsida Os.9284 35
Os02g0732500 35
  • 60.87 (n)
  • 61.41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4095 36
  • 85 (a)
Species with no ortholog for ARL8B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARL8B Gene

Gene Tree for ARL8B (if available)
Gene Tree for ARL8B (if available)

Paralogs for ARL8B Gene

Paralogs for ARL8B Gene Pseudogenes for ARL8B Gene

genes like me logo Genes that share paralogs with ARL8B: view

Variants for ARL8B Gene

Sequence variations from dbSNP and Humsavar for ARL8B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs397188 -- 5,151,872(+) ggctc(A/G)cacga intron-variant
rs2291865 -- 5,138,766(+) GAGAA(A/G)TGTAC intron-variant
rs1137796 -- 5,152,582(-) gttta(A/G)gtcca intron-variant
rs564921 -- 5,135,303(+) tattt(A/T)ttttt intron-variant
rs865566 -- 5,141,216(+) CATCC(A/G)CAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARL8B Gene

Variant ID Type Subtype PubMed ID
esv2671785 CNV Deletion 23128226
esv2484755 CNV Deletion 19546169

Variation tolerance for ARL8B Gene

Residual Variation Intolerance Score: 57.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.36% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ARL8B Gene

Disorders for ARL8B Gene

Relevant External Links for ARL8B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARL8B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL8B Gene

Publications for ARL8B Gene

  1. An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility. (PMID: 16537643) Hofmann I. … Munro S. (J. Cell Sci. 2006) 3 4 23 67
  2. Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity. (PMID: 24088571) Tuli A. … Brenner M.B. (Mol. Biol. Cell 2013) 2 3
  3. Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation. (PMID: 15331635) Okai T. … Katada T. (J. Cell Sci. 2004) 3 23
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3

Products for ARL8B Gene

Sources for ARL8B Gene