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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARL8B Gene

protein-coding   GIFtS: 48
GCID: GC03P005163

ADP-ribosylation factor-like 8B

(Previous name: ADP-ribosylation factor-like 10C )
(Previous symbol: ARL10C)
  Search for ARL8B
in our new
 Human Malady Compendium 
Biological research products
for ARL8B
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
ADP-Ribosylation Factor-Like 8B1 2     ADP-Ribosylation Factor-Like Protein 10C2 3
ARL10C1 2 3     FLJ107021
Gie11 2     ADP-Ribosylation Factor-Like Protein 8B2
ADP-Ribosylation Factor-Like 10C1 2     GIE13
Novel Small G Protein Indispensable For Equal Chromosome Segregation 12 3     

External Ids:    HGNC: 255641   Entrez Gene: 552072   Ensembl: ENSG000001341087   UniProtKB: Q9NVJ23   

Export aliases for ARL8B gene to outside databases

Previous GC identifers: GC03P005139 GC03P005096


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ARL8B_HUMAN, Q9NVJ2
Function: May play a role in lysosome motility (PubMed:16537643). May play a role in chromosome segregation
(PubMed:15331635)

Gene Wiki entry for ARL8B


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARL8B gene promoter:
         C/EBPbeta   Pbx1a   Meis-1a   POU3F2   LyF-1   Meis-1   Meis-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARL8B promoter sequence
   Search SABiosciences Chromatin IP Primers for ARL8B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL8B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p26.1   Ensembl cytogenetic band:  3p26.1   HGNC cytogenetic band: 3p26.1

ARL8B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL8B gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P005163:  view genomic region     (about GC identifiers)

Start:
5,163,905 bp from pter      End:
5,222,601 bp from pter
Size:
58,697 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ARL8B_HUMAN, Q9NVJ2 (See protein sequence)
Recommended Name: ADP-ribosylation factor-like protein 8B  
Size: 186 amino acids; 21539 Da
Subunit: Interacts with tubulin
Subcellular location: Late endosome membrane. Lysosome membrane. Cytoplasm, cytoskeleton, spindle. Note=According to
PubMed:15331635, it localizes with microtubules at the spindle mid-zone during mitosis
1 PDB 3D structure from and Proteopedia for ARL8B:
2AL7 (3D)    

Explore the universe of human proteins at neXtProt for ARL8B: NX_Q9NVJ2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NVJ2

  • ARL8B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060654.1  
    ENSEMBL proteins: 
     ENSP00000256496   ENSP00000405196   ENSP00000400831   ENSP00000402996  

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    Uscn Proteins for ARL8B

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA15331635
    GO:0005765lysosomal membrane IEA--
    GO:0030496midbody IDA15331635
    GO:0031902late endosome membrane IEA--


    ARL8B for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ARL8B for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF
     IPR005225 Small_GTP-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q9NVJ2

    ProtoNet protein and cluster: Q9NVJ2

    1 Blocks protein family: IPB006688 ADP-ribosylation factor

    UniProtKB/Swiss-Prot: ARL8B_HUMAN, Q9NVJ2
    Similarity: Belongs to the small GTPase superfamily. Arf family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ARL8B_HUMAN, Q9NVJ2
    Function: May play a role in lysosome motility (PubMed:16537643). May play a role in chromosome segregation
    (PubMed:15331635)

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    hsa-miR-320a hsa-miR-549 hsa-miR-4291 hsa-miR-1283 hsa-miR-148b hsa-miR-539 hsa-miR-320d hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidARL8B 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity NAS15331635
    GO:0005525GTP binding IDA15331635
    GO:0019003GDP binding IDA15331635
    GO:0043014alpha-tubulin binding IDA15331635
    GO:0048487beta-tubulin binding IDA15331635


    ARL8B for ontologies           About GeneDecksing


    Animal Models:
         1 MGI phenotypic allele for Arl8b (no phenotypes)

    ARL8B for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARL8B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/45 Interacting proteins for ARL8B (Q9NVJ22, 3 ENSP000002564964) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP5J2P561342, 3MINT-63900 I2D: score=4 
    DLEU1O432612, 3MINT-63128 I2D: score=2 
    TUBB2AQ138853, ENSP000003697034I2D: score=1 STRING: ENSP00000369703
    ATP6V1AP386062, ENSP000002733984MINT-4054731 STRING: ENSP00000273398
    TGFBR1P368973, ENSP000003641334I2D: score=3 STRING: ENSP00000364133
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process NAS15331635
    GO:0007049cell cycle IEA--
    GO:0007059chromosome segregation IMP14871887
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0051301cell division IEA--


    ARL8B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARL8B
    Search CenterWatch for drugs/clinical trials and news about ARL8B 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARL8B gene: 
    NM_018184.2  

    Unigene Cluster for ARL8B:

    ADP-ribosylation factor-like 8B
    Hs.665686  [show with all ESTs]
    Unigene Representative Sequence: BC063125
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256496(uc003bqg.3 uc011asx.2 uc011asy.2) ENST00000429403
    ENST00000444332 ENST00000455168 ENST00000419534 ENST00000468010 ENST00000476343


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    hsa-miR-320a hsa-miR-549 hsa-miR-4291 hsa-miR-1283 hsa-miR-148b hsa-miR-539 hsa-miR-320d hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidARL8B 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AB118751.1 AF086108.1 AK001564.1 AK295465.1 AK298951.1 AK303872.1 AL110242.1 BC013131.1 
    BC063125.1 CR457264.1 

    19 DOTS entries:

    DT.100825344  DT.215120  DT.100825334  DT.100825340  DT.100008153  DT.95234674  DT.95155769  DT.97848315 
    DT.120888905  DT.75147555  DT.95245129  DT.120888903  DT.120888910  DT.120888974  DT.120888984  DT.95157694 
    DT.95234631  DT.100719150  DT.95303440 

    24/389 AceView cDNA sequences (see all 389):

    CR599429 CR606808 AI025558 AI191571 BM554268 BQ008167 N41716 AW189339 
    BQ718928 AB118751 BM919609 CB997373 AU132388 CB990281 AA227124 BF969208 
    BX330117 AI567812 AI090528 CB217012 AI003080 AI276494 BC013131 BE875258 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ARL8B (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b
    SP1:                                -                       -                                                                     
    SP2:                                -                       -                                                                     
    SP3:                                -           -     -     -                                                                     
    SP4:                                -                 -     -                                                                     
    SP5:                                -                       -                       -     -     -     -     -     -               


    ECgene alternative splicing isoforms for ARL8B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARL8B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGGAAGGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ARL8B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARL8B

    SOURCE GeneReport for Unigene cluster: Hs.665686

    UniProtKB/Swiss-Prot: ARL8B_HUMAN, Q9NVJ2
    Tissue specificity: Ubiquitously expressed

        SABiosciences Custom PCR Arrays for ARL8B
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARL8B gene from 8/32 species (see all 32)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ARL8B1 ADP-ribosylation factor-like 8B 89.61(n)
    98.39(a)
      416109  XM_414440.3  XP_414440.3 
    lizard
    (Anolis carolinensis)
    Reptilia ARL8B6
    --
    98(a)
    1 ↔ 1
    2(172906531-172936145)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA982693.12   -- 81.03(n)    CA982693.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.197642 Danio rerio cDNA clone IMAGE5604898 78.25(n)    BC052221.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gie6
    GTPase indispensable for equal segregation of chro...
    87(a)
    1 → many
    3R(3952336-3954568)
    worm
    (Caenorhabditis elegans)
    Secernentea arl-86
    ARF-Like family member (arl-8)
    85(a)
    1 → many
    IV(14798108-14799278)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ARLA1A1 ADP-ribosylation factor-like A1A 62.27(n)
    64.29(a)
      833747  NM_123127.3  NP_568553.1 
    rice
    (Oryza sativa)
    Liliopsida Os.92842 Oryza sativa (japonica cultivar-group) cDNA clone0 more 71.51(n)    AK112007.1 


    ENSEMBL Gene Tree for ARL8B (if available)
    TreeFam Gene Tree for ARL8B (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARL8B gene
    ARL152  ARL22  ARL8A2  ARL32  
    18/30 SIMAP similar genes for ARL8B using alignment to 4 protein entries:     ARL8B_HUMAN (see all proteins) (see all similar genes):
    ARL8A    ARL6    ARF3    ARL3    SAR1A    ARL2
    ARF5    ARL14    ARL15    ARL4A    SARA1    ARF1
    ARL10    ARL11    ARF4    ARF6    ARL1    ARL4D

    ARL8B for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for ARL8B
    PGOHUM00000234352 PGOHUM00000263024 PGOHUM00000263124 PGOHUM00000236731


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1179 NCBI SNPs in ARL8B are shown (see all 1179    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1404884681,2
    --5161933(+) AACCCC/TGTCTC 1 -- us2k10--------
    rs1872580491,2
    --5161977(+) GGCGGA/GCGCCT 1 -- us2k10--------
    rs1115908201,2
    C,--5161992(+) TCCCAG/ACTACT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1920075551,2
    --5162022(+) AATGGC/TGTGAA 1 -- us2k10--------
    rs1122348891,2
    C,--5162058(+) CCGAGG/ATCGCA 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs612595541,2
    C--5162106(+) AAAAA-/AA    
       AAAAA
    GAAAG
    1 -- us2k10--------
    rs755449741,2
    --5162136(+) AAACAA/GCAAAC 1 -- us2k13Minor allele frequency- G:0.12CSA WA EA 239
    rs1858686541,2
    --5162402(+) CAAGAG/TACTGA 1 -- us2k10--------
    rs1900815031,2
    --5162518(+) GTCTCC/GCTCTG 1 -- us2k10--------
    rs1826876371,2
    --5162537(+) GCTGGC/TGTGCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARL8B (5163905 - 5222601 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ARL8B
         1 CNV: 98219

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARL8B gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with ARL8B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility. (PubMed id 16537643)1, 2, 9 Hofmann I. and Munro S. (2006)
    2. Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation. (PubMed id 15331635)1, 2, 9 Okai T.... Katada T. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. Lysosomal trafficking, antigen presentation, and micr obial killing are controlled by the Arf-like GTPase Arl8b. (PubMed id 21802320)1 Garg S....Brenner M.B. (2011)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Salmonella exploits Arl8B-directed kinesin activity t o promote endosome tubulation and cell-to-cell transfer. (PubMed id 21824248)1 Kaniuk N.A....Brumell J.H. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55207 HGNC: 25564 AceView: ARL10C Ensembl:ENSG00000134108 euGenes: HUgn55207
    ECgene: ARL8B H-InvDB: ARL8B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARL8B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARL8B gene:
    Search GeneIP for patents involving ARL8B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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