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ARL8B Gene

protein-coding   GIFtS: 51
GCID: GC03P005163

ADP-Ribosylation Factor-Like 8B

(Previous name: ADP-ribosylation factor-like 10C)
(Previous symbol: ARL10C)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADP-Ribosylation Factor-Like 8B1 2     ADP-Ribosylation Factor-Like Protein 10C2 3
ARL10C1 2 3     Gie12
ADP-Ribosylation Factor-Like 10C1 2     ADP-Ribosylation Factor-Like Protein 8B2
Novel Small G Protein Indispensable For Equal Chromosome Segregation 12 3     GIE13

External Ids:    HGNC: 255641   Entrez Gene: 552072   Ensembl: ENSG000001341087   UniProtKB: Q9NVJ23   

Export aliases for ARL8B gene to outside databases

Previous GC identifers: GC03P005139 GC03P005096


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ARL8B Gene:
ARL8B (ADP-ribosylation factor-like 8B) is a protein-coding gene. GO annotations related to this gene include GDP binding and GTP binding. An important paralog of this gene is ARL15.

UniProtKB/Swiss-Prot: ARL8B_HUMAN, Q9NVJ2
Function: May play a role in lysosome motility (PubMed:16537643). May play a role in chromosome segregation
(PubMed:15331635)

Gene Wiki entry for ARL8B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARL8B gene promoter:
         C/EBPbeta   Pbx1a   Meis-1a   POU3F2   LyF-1   Meis-1   Meis-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARL8B promoter sequence
   Search Chromatin IP Primers for ARL8B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARL8B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p26.1   Ensembl cytogenetic band:  3p26.1   HGNC cytogenetic band: 3p26.1

ARL8B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL8B gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P005163:  view genomic region     (about GC identifiers)

Start:
5,163,905 bp from pter      End:
5,222,601 bp from pter
Size:
58,697 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ARL8B_HUMAN, Q9NVJ2 (See protein sequence)
Recommended Name: ADP-ribosylation factor-like protein 8B  
Size: 186 amino acids; 21539 Da
Subunit: Interacts with tubulin
1 PDB 3D structure from and Proteopedia for ARL8B:
2AL7 (3D)    

Explore the universe of human proteins at neXtProt for ARL8B: NX_Q9NVJ2

Explore proteomics data for ARL8B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys141, Lys146, Lys182
  • Modification sites at PhosphoSitePlus

  • See ARL8B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060654.1  
    ENSEMBL proteins: 
     ENSP00000256496   ENSP00000405196   ENSP00000400831   ENSP00000402996  

    ARL8B Human Recombinant Protein Products:

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    antibodies-online proteins for ARL8B (4 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARL: ADP-ribosylation factors-like
    ARF: ADP-ribosylation factors

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR027417 P-loop_NTPase
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF

    Graphical View of Domain Structure for InterPro Entry Q9NVJ2

    ProtoNet protein and cluster: Q9NVJ2

    1 Blocks protein domain: IPB006688 ADP-ribosylation factor

    UniProtKB/Swiss-Prot: ARL8B_HUMAN, Q9NVJ2
    Similarity: Belongs to the small GTPase superfamily. Arf family


    Find genes that share domains with ARL8B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARL8B_HUMAN, Q9NVJ2
    Function: May play a role in lysosome motility (PubMed:16537643). May play a role in chromosome segregation
    (PubMed:15331635)

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity NAS15331635
    GO:0004871signal transducer activity ----
    GO:0005525GTP binding IDA15331635
    GO:0019001guanyl nucleotide binding ----
    GO:0019003GDP binding IDA15331635
         
    Find genes that share ontologies with ARL8B           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Arl8b (no phenotypes)

    Find genes that share phenotypes with ARL8B           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ARL8B

    miRNA
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    miRTarBase miRNAs that target ARL8B:
    hsa-mir-26b-5p (MIRT029716), hsa-mir-148b-3p (MIRT019388), hsa-mir-155-5p (MIRT020834)

    Block miRNA regulation of human, mouse, rat ARL8B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARL8B (see all 15):
    hsa-miR-320a hsa-miR-549 hsa-miR-4291 hsa-miR-1283 hsa-miR-148b hsa-miR-539 hsa-miR-320d hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidARL8B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARL8B

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    Addgene plasmids for ARL8B 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARL8B_HUMAN, Q9NVJ2: Late endosome membrane. Lysosome membrane. Cytoplasm, cytoskeleton, spindle. Note=According
    to PubMed:15331635, it localizes with microtubules at the spindle mid-zone during mitosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    endosome5
    lysosome5
    vacuole5
    cytosol3
    nucleus2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm IDA15331635
    GO:0005765lysosomal membrane IEA--
    GO:0016020membrane ----

    Find genes that share ontologies with ARL8B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARL8B
    Interactions:

        Search GeneGlobe Interaction Network for ARL8B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARL8B (Q9NVJ22, 3 ENSP000002564964) via UniProtKB, MINT, STRING, and/or I2D (see all 93)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP5J2P561342, 3MINT-63900 I2D: score=4 
    DLEU1O432612, 3MINT-63128 I2D: score=2 
    ENSG00000232575P074373, ENSP000004100714I2D: score=1 STRING: ENSP00000410071
    ENSG00000183311P074373I2D: score=1 
    ENSG00000224156P074373I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process NAS15331635
    GO:0006886intracellular protein transport ----
    GO:0007049cell cycle IEA--
    GO:0007059chromosome segregation IMP14871887
    GO:0007165signal transduction ----

    Find genes that share ontologies with ARL8B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARL8B



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARL8B gene: 
    NM_018184.2  

    Unigene Cluster for ARL8B:

    ADP-ribosylation factor-like 8B
    Hs.250009  [show with all ESTs]
    Unigene Representative Sequence: BC063125
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256496(uc003bqg.3 uc011asx.2 uc011asy.2) ENST00000429403
    ENST00000444332 ENST00000455168 ENST00000419534 ENST00000468010 ENST00000476343

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    Selected qRT-PCR Assays for microRNAs that regulate ARL8B (see all 15):
    hsa-miR-320a hsa-miR-549 hsa-miR-4291 hsa-miR-1283 hsa-miR-148b hsa-miR-539 hsa-miR-320d hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidARL8B 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB118751.1 AF086108.1 AK001564.1 AK295465.1 AK298951.1 AK303872.1 AL110242.1 BC013131.1 
    BC063125.1 CR457264.1 

    19 DOTS entries:

    DT.100825344  DT.215120  DT.100825334  DT.100825340  DT.100008153  DT.95234674  DT.95155769  DT.97848315 
    DT.120888905  DT.75147555  DT.95245129  DT.120888903  DT.120888910  DT.120888974  DT.120888984  DT.95157694 
    DT.95234631  DT.95303440  DT.100719150 

    Selected AceView cDNA sequences (see all 389):

    BM554268 BP354946 N41716 BG776804 BM831976 CD676374 CB217012 CR610251 
    BX330117 CB996478 BM919609 BQ718928 BM549262 BP366068 AW189339 CA435773 
    CR602370 CB997373 BG403322 BM764887 BM126873 AI567812 AI276494 AA227124 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARL8B (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b
    SP1:                                -                       -                                                                     
    SP2:                                -                       -                                                                     
    SP3:                                -           -     -     -                                                                     
    SP4:                                -                 -     -                                                                     
    SP5:                                -                       -                       -     -     -     -     -     -               


    ECgene alternative splicing isoforms for ARL8B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARL8B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGAAGGTG
    ARL8B Expression
    About this image


    ARL8B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Thyroid (Endocrine System)
     
     Esophagus (Gastrointestinal Tract)
    ARL8B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARL8B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.250009

    UniProtKB/Swiss-Prot: ARL8B_HUMAN, Q9NVJ2
    Tissue specificity: Ubiquitously expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL8B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARL8B gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arl8b1 , 5 ADP-ribosylation factor-like 8B1, 5 94.62(n)1
    100(a)1
      6 (49.87 cM)5
    671661  NM_026011.31  NP_080287.11 
     1087830595 
    chicken
    (Gallus gallus)
    Aves ARL8B1 ADP-ribosylation factor-like 8B 89.61(n)
    98.39(a)
      416109  XM_414440.4  XP_414440.3 
    lizard
    (Anolis carolinensis)
    Reptilia ARL8B6
    ADP-ribosylation factor-like 8B
    98(a)
    1 ↔ 1
    2(172906470-172936153)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA982693.12   -- 81.03(n)    CA982693.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.197642 Danio rerio cDNA clone IMAGE5604898 78.25(n)    BC052221.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gie6
    GTPase indispensable for equal segregation of chro...
    87(a)
    1 → many
    3R(3952336-3954568)
    worm
    (Caenorhabditis elegans)
    Secernentea arl-86
    Protein ARL-8 (arl-8) mRNA, complete cds
    85(a)
    1 → many
    IV(14798149-14799310) WBGene00000192
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ARLA1A1 ARLA1A 62.27(n)
    64.29(a)
      833747  NM_123127.3  NP_568553.1 
    rice
    (Oryza sativa)
    Liliopsida Os.92842 Oryza sativa (japonica cultivar-group) cDNA clone0 more 71.51(n)    AK112007.1 


    ENSEMBL Gene Tree for ARL8B (if available)
    TreeFam Gene Tree for ARL8B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARL8B gene
    ARL152  ARL92  ARL62  ARL8A2  ARL102  ARL12  
    Selected SIMAP similar genes for ARL8B using alignment to 4 protein entries:     ARL8B_HUMAN (see all proteins) (see all similar genes):
    ARL8A    ARL6    ARF3    ARL3    SAR1A    ARF5
    ARL14    ARL15    ARL4A    SARA1    ARF1    ARL10
    ARL11    ARF4    ARF6    ARL2    ARL1    ARL4D

    Find genes that share paralogs with ARL8B           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for ARL8B
    PGOHUM00000234352 PGOHUM00000263024 PGOHUM00000263124 PGOHUM00000236731


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARL8B (see all 1391)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1404884681,2
    C--5161933(+) AACCCC/TGTCTC 1 -- us2k10--------
    rs1872580491,2
    C--5161977(+) GGCGGA/GCGCCT 1 -- us2k10--------
    rs1115908201,2
    C,F--5161992(+) TCCCAG/ACTACT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1920075551,2
    C--5162022(+) AATGGC/TGTGAA 1 -- us2k10--------
    rs1122348891,2
    C,F--5162058(+) CCGAGG/ATCGCA 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs612595541,2
    C--5162106(+) AAAAA-/AA    
       AAAAA
    GAAAG
    1 -- us2k10--------
    rs755449741,2
    C--5162136(+) AAACAA/GCAAAC 1 -- us2k13Minor allele frequency- G:0.12CSA WA EA 239
    rs1858686541,2
    --5162402(+) CAAGAG/TACTGA 1 -- us2k10--------
    rs1900815031,2
    --5162518(+) GTCTCC/GCTCTG 1 -- us2k10--------
    rs1826876371,2
    --5162537(+) GCTGGC/TGTGCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARL8B (5163905 - 5222601 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ARL8B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2484755CNV Deletion19546169
    esv2671785CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARL8B
    DNA2.0 Custom Variant and Variant Library Synthesis for ARL8B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARL8B gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with ARL8B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility. (PubMed id 16537643)1, 2, 9 Hofmann I. and Munro S. (J. Cell Sci. 2006)
    2. Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation. (PubMed id 15331635)1, 2, 9 Okai T.... Katada T. (J. Cell Sci. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects. (PubMed id 22993228)1 Williams F.M....Spector T.D. (Ann. Rheum. Dis. 2013)
    7. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    10. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55207 HGNC: 25564 AceView: ARL10C Ensembl:ENSG00000134108 euGenes: HUgn55207
    ECgene: ARL8B H-InvDB: ARL8B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ARL8B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ARL8B gene:
    Search GeneIP for patents involving ARL8B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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