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Aliases for ARL8A Gene

Aliases for ARL8A Gene

  • ADP Ribosylation Factor Like GTPase 8A 2 3 5
  • Novel Small G Protein Indispensable For Equal Chromosome Segregation 2 3 4
  • ADP-Ribosylation Factor-Like 10B 2 3
  • ADP-Ribosylation Factor-Like 8A 2 3
  • ARL10B 3 4
  • GIE2 3 4
  • ADP-Ribosylation Factor-Like Protein 10B 4
  • ADP-Ribosylation Factor Like GTPase 8A 3

External Ids for ARL8A Gene

Previous HGNC Symbols for ARL8A Gene

  • ARL10B

Previous GeneCards Identifiers for ARL8A Gene

  • GC01M198834
  • GC01M200368
  • GC01M202102
  • GC01M173267

Summaries for ARL8A Gene

GeneCards Summary for ARL8A Gene

ARL8A (ADP Ribosylation Factor Like GTPase 8A) is a Protein Coding gene. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is ARL1.

UniProtKB/Swiss-Prot for ARL8A Gene

  • May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity).

Gene Wiki entry for ARL8A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL8A Gene

Genomics for ARL8A Gene

Regulatory Elements for ARL8A Gene

Enhancers for ARL8A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARL8A on UCSC Golden Path with GeneCards custom track

Promoters for ARL8A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARL8A on UCSC Golden Path with GeneCards custom track

Genomic Location for ARL8A Gene

202,133,404 bp from pter
202,144,743 bp from pter
11,340 bases
Minus strand

Genomic View for ARL8A Gene

Genes around ARL8A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL8A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL8A Gene

Proteins for ARL8A Gene

  • Protein details for ARL8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP-ribosylation factor-like protein 8A
    Protein Accession:
    Secondary Accessions:
    • B3KXD0

    Protein attributes for ARL8A Gene

    186 amino acids
    Molecular mass:
    21416 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ARL8A Gene

neXtProt entry for ARL8A Gene

Proteomics data for ARL8A Gene at MOPED

Post-translational modifications for ARL8A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARL8A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARL8A Gene

Domains & Families for ARL8A Gene

Gene Families for ARL8A Gene

Protein Domains for ARL8A Gene

Suggested Antigen Peptide Sequences for ARL8A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Arf family.
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL8A: view

Function for ARL8A Gene

Molecular function for ARL8A Gene

UniProtKB/Swiss-Prot Function:
May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity).

Gene Ontology (GO) - Molecular Function for ARL8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24955142
genes like me logo Genes that share ontologies with ARL8A: view
genes like me logo Genes that share phenotypes with ARL8A: view

Animal Model Products

miRNA for ARL8A Gene

miRTarBase miRNAs that target ARL8A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL8A Gene

Localization for ARL8A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL8A Gene

Late endosome membrane. Lysosome membrane.

Subcellular locations from

Jensen Localization Image for ARL8A Gene COMPARTMENTS Subcellular localization image for ARL8A gene
Compartment Confidence
cytoskeleton 5
endosome 5
extracellular 5
lysosome 5
vacuole 5
cytosol 3
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ARL8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
GO:0016020 membrane IDA 19946888
GO:0031902 late endosome membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ARL8A: view

Pathways & Interactions for ARL8A Gene

SuperPathways for ARL8A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with ARL8A: view

No data available for Pathways by source and SIGNOR curated interactions for ARL8A Gene

Drugs & Compounds for ARL8A Gene

No Compound Related Data Available

Transcripts for ARL8A Gene

Unigene Clusters for ARL8A Gene

ADP-ribosylation factor-like 8A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARL8A Gene

No ASD Table

Relevant External Links for ARL8A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARL8A Gene

mRNA expression in normal human tissues for ARL8A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARL8A Gene

This gene is overexpressed in Nasal epithelium (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARL8A Gene

SOURCE GeneReport for Unigene cluster for ARL8A Gene Hs.497399

mRNA Expression by UniProt/SwissProt for ARL8A Gene

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with ARL8A: view

Protein tissue co-expression partners for ARL8A Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for ARL8A Gene

Orthologs for ARL8A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARL8A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARL8A 35
  • 92.7 (n)
  • 100 (a)
ARL8A 36
  • 99 (a)
(Mus musculus)
Mammalia Arl8a 35
  • 92.47 (n)
  • 99.46 (a)
Arl8a 16
Arl8a 36
  • 99 (a)
(Pan troglodytes)
Mammalia ARL8A 35
  • 98.1 (n)
  • 97.71 (a)
ARL8A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Arl8a 35
  • 93.01 (n)
  • 99.46 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia ARL8A 36
  • 78 (a)
(Gallus gallus)
Aves ARL8A 35
  • 88.17 (n)
  • 98.92 (a)
-- 36
  • 93 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arl8a 35
  • 81.54 (n)
  • 97.31 (a)
(Danio rerio)
Actinopterygii arl8a 35
  • 84.59 (n)
  • 97.31 (a)
arl8a 36
  • 96 (a)
fruit fly
(Drosophila melanogaster)
Insecta Gie 36
  • 87 (a)
(Caenorhabditis elegans)
Secernentea arl-8 35
  • 72.07 (n)
  • 84.86 (a)
arl-8 36
  • 85 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ARLA1D 35
  • 62.64 (n)
  • 63.74 (a)
(Oryza sativa)
Liliopsida Os03g0200800 35
  • 60.84 (n)
  • 61.75 (a)
(Triticum aestivum)
Liliopsida Ta.3262 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08618 35
  • 56.91 (n)
  • 54.14 (a)
Species with no ortholog for ARL8A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ARL8A Gene

Gene Tree for ARL8A (if available)
Gene Tree for ARL8A (if available)

Paralogs for ARL8A Gene

Paralogs for ARL8A Gene

(28) SIMAP similar genes for ARL8A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARL8A: view

Variants for ARL8A Gene

Sequence variations from dbSNP and Humsavar for ARL8A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs3820382 -- 202,133,981(+) CCCCA(A/G)GTCCA utr-variant-3-prime
rs4363479 -- 202,143,157(+) TCGAG(A/G)AAGGG intron-variant
rs3934809 -- 202,143,771(-) AGTTT(G/T)CAGGA intron-variant
rs4989100 -- 202,144,707(+) GCGGC(G/T)GCCGA utr-variant-5-prime
rs4342901 -- 202,134,674(+) CTCAG(A/G)TGAGA intron-variant

Variation tolerance for ARL8A Gene

Residual Variation Intolerance Score: 34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.88% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ARL8A Gene

Disorders for ARL8A Gene

Relevant External Links for ARL8A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARL8A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL8A Gene

Publications for ARL8A Gene

  1. An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility. (PMID: 16537643) Hofmann I. … Munro S. (J. Cell Sci. 2006) 3 4 23 67
  2. Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation. (PMID: 15331635) Okai T. … Katada T. (J. Cell Sci. 2004) 3 23
  3. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for ARL8A Gene

Sources for ARL8A Gene