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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARL8A Gene

protein-coding   GIFtS: 47
GCID: GC01M202102

ADP-ribosylation factor-like 8A

(Previous name: ADP-ribosylation factor-like 10B )
(Previous symbol: ARL10B)
  Search for ARL8A
in our new
 Human Malady Compendium 
Biological research products
for ARL8A
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
ADP-Ribosylation Factor-Like 8A1 2     FLJ451951
ARL10B1 2 3     Gie21
ADP-Ribosylation Factor-Like 10B1 2     ADP-Ribosylation Factor-Like Protein 8A2
Novel Small G Protein Indispensable For Equal Chromosome Segregation 22 3     ADP-Ribosylation Factor-Like Protein 10B3
GIE22 3     

External Ids:    HGNC: 251921   Entrez Gene: 1278292   Ensembl: ENSG000001438627   UniProtKB: Q96BM93   

Export aliases for ARL8A gene to outside databases

Previous GC identifers: GC01M198834 GC01M200368 GC01M173267


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ARL8A_HUMAN, Q96BM9
Function: May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By
similarity)

Gene Wiki entry for ARL8A


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARL8A gene promoter:
         E2F-4   E2F-3a   E2F-1   E2F   Hand1   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARL8A promoter sequence
   Search SABiosciences Chromatin IP Primers for ARL8A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL8A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

ARL8A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL8A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M202102:  view genomic region     (about GC identifiers)

Start:
202,101,977 bp from pter      End:
202,113,869 bp from pter
Size:
11,893 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ARL8A_HUMAN, Q96BM9 (See protein sequence)
Recommended Name: ADP-ribosylation factor-like protein 8A  
Size: 186 amino acids; 21416 Da
Subcellular location: Late endosome membrane. Lysosome membrane
2 PDB 3D structures from and Proteopedia for ARL8A:
1ZD9 (3D)        2H18 (3D)    
Secondary accessions: B3KXD0

Explore the universe of human proteins at neXtProt for ARL8A: NX_Q96BM9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96BM9

  • ARL8A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243058.1  NP_620150.1  

    ENSEMBL proteins: 
     ENSP00000272217  

    Human Recombinant Protein Products: 
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    Uscn Proteins for ARL8A

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA15331635
    GO:0005765lysosomal membrane IEA--
    GO:0030496midbody IDA15331635
    GO:0031902late endosome membrane IEA--
    GO:0051233spindle midzone IDA15331635


    ARL8A for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ARL8A for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF
     IPR005225 Small_GTP-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q96BM9

    ProtoNet protein and cluster: Q96BM9

    1 Blocks protein family: IPB006688 ADP-ribosylation factor

    UniProtKB/Swiss-Prot: ARL8A_HUMAN, Q96BM9
    Similarity: Belongs to the small GTPase superfamily. Arf family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ARL8A_HUMAN, Q96BM9
    Function: May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By
    similarity)

    miRNA
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    hsa-miR-4291 hsa-miR-330-5p hsa-miR-146a hsa-let-7a-2* hsa-miR-3916 hsa-miR-105 hsa-miR-1184 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidARL8A 3' UTR sequence
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity NAS15331635
    GO:0005525GTP binding IDA15331635
    GO:0043014alpha-tubulin binding ISS15331635
    GO:0048487beta-tubulin binding ISS15331635


    ARL8A for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ARL8A:
     Synthetic lethal with Ras 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARL8A

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for ARL8A (Q96BM93 ENSP000002722174) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP5J2P561343I2D: score=1 
    DLEU1O432613I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process NAS15331635
    GO:0007059chromosome segregation ISS14871887
    GO:0007067mitosis IEA--
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0051301cell division IEA--


    ARL8A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARL8A
    Search CenterWatch for drugs/clinical trials and news about ARL8A 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARL8A gene (2 alternative transcripts): 
    NM_001256129.1  NM_138795.3  

    Unigene Cluster for ARL8A:

    ADP-ribosylation factor-like 8A
    Hs.497399  [show with all ESTs]
    Unigene Representative Sequence: NM_138795
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000272217(uc001gxk.1) ENST00000491358 ENST00000486225

    miRNA
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    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate ARL8A (see all 46):
    hsa-miR-4291 hsa-miR-330-5p hsa-miR-146a hsa-let-7a-2* hsa-miR-3916 hsa-miR-105 hsa-miR-1184 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidARL8A 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AB118752.1 AK127138.1 AK313122.1 BC015408.1 BC053358.1 BC069053.1 

    10 DOTS entries:

    DT.100022265  DT.100777524  DT.100809776  DT.100777526  DT.92428943  DT.86846604  DT.95170644  DT.95211425 
    DT.99935739  DT.92428945 

    24/166 AceView cDNA sequences (see all 166):

    BQ639457 AW516069 T32205 BQ672070 AB118752 CA310243 AW138323 BU149918 
    BC015408 CR597275 BM999456 BF221924 BM548962 AI356608 AI968307 BG030253 
    NM_138795 BM693789 AI597717 BQ072223 BU738229 BM980443 CR624011 BQ898276 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARL8A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGGGTTGGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    ARL8A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeRetinaEye
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)

    See ARL8A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARL8A

    SOURCE GeneReport for Unigene cluster: Hs.497399

    UniProtKB/Swiss-Prot: ARL8A_HUMAN, Q96BM9
    Tissue specificity: Ubiquitously expressed

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARL8A gene from 8/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ARL8A1 ADP-ribosylation factor-like 8A 88.17(n)
    98.92(a)
      421175  NM_001012868.1  NP_001012886.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARL8A6
    --
    98(a)
    1 ↔ 1
    4(132567488-132624485)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BC061301.12   -- 81.28(n)    BC061301.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC056568.12   -- 84.39(n)    BC056568.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gie6
    GTPase indispensable for equal segregation of chro...
    87(a)
    1 → many
    3R(3952336-3954568)
    worm
    (Caenorhabditis elegans)
    Secernentea arl-81 Protein ARL-8 72.07(n)
    84.86(a)
      178405  NM_070390.5  NP_502791.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ARLA1D1 ADP-ribosylation factor-like A1D 62.64(n)
    63.74(a)
      836892  NM_126156.4  NP_569051.1 
    rice
    (Oryza sativa)
    Liliopsida AK111722.12   -- 73.61(n)    AK111722.1 


    ENSEMBL Gene Tree for ARL8A (if available)
    TreeFam Gene Tree for ARL8A (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARL8A gene
    ARL152  ARL22  ARL8B2  ARL32  
    18/28 SIMAP similar genes for ARL8A using alignment to 1 protein entry:     ARL8A_HUMAN(see all similar genes):
    ARL8B    ARL6    ARL15    ARL4A    SAR1B    ARF3
    ARL3    SAR1A    ARF5    ARL2    ARL4D    SARA1
    ARF1    ARF4    ARF6    ARL14    ARL1    ARL11

    ARL8A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/186 NCBI SNPs in ARL8A are shown (see all 186    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1456324161,2
    --202102097(+) GGGACA/GGGGTT 2 -- int10--------
    rs585302581,2
    C,--202102164(+) TGAGGC/ACTGAA 2 -- int12Minor allele frequency- A:0.12WA 120
    rs168497071,2
    C,F,H,--202102378(+) AGGCCG/ATTTTG 2 -- int1 ese37Minor allele frequency- A:0.01NA NS EA 558
    rs412709671,2
    C,F,--202102392(+) AGCGCC/TATTGT 2 -- int12Minor allele frequency- T:0.06WA NA 238
    rs598506711,2
    C,--202102408(+) CCGGGC/TGGGCA 2 -- int12Minor allele frequency- T:0.04WA 120
    rs1430375691,2
    --202102539(+) CAACAC/TAAAAC 2 -- ut310--------
    rs1910519181,2
    --202102803(+) CCCTGA/GGGAGG 2 -- ut310--------
    rs75201591,2
    C,F,H,--202102824(+) GGGAGC/TCAGGA 2 -- ut31 ese35Minor allele frequency- T:0.04NS EA WA 536
    rs1434110331,2
    --202102860(+) ATGGAC/TGCTGG 2 -- ut310--------
    rs1153415301,2
    C,F,--202102939(+) GGGGTC/TGAGGG 2 -- ut311Minor allele frequency- T:0.09WA 118

    HapMap Linkage Disequilibrium report for ARL8A (202101977 - 202113869 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ARL8A: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARL8A gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with ARL8A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility. (PubMed id 16537643)1, 2, 9 Hofmann I. and Munro S. (2006)
    2. Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation. (PubMed id 15331635)1, 2, 9 Okai T.... Katada T. (2004)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1, 3 Bonaldo M.F.... Soares M.B. (1996)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 127829 HGNC: 25192 AceView: ARL10B Ensembl:ENSG00000143862 euGenes: HUgn127829
    ECgene: ARL8A H-InvDB: ARL8A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARL8A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARL8A gene:
    Search GeneIP for patents involving ARL8A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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