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Aliases for ARL8A Gene

Aliases for ARL8A Gene

  • ADP-Ribosylation Factor-Like 8A 2 3
  • Novel Small G Protein Indispensable For Equal Chromosome Segregation 2 3 4
  • ADP-Ribosylation Factor-Like 10B 2 3
  • ARL10B 3 4
  • GIE2 3 4
  • ADP-Ribosylation Factor-Like Protein 10B 4
  • ADP-Ribosylation Factor-Like Protein 8A 3

External Ids for ARL8A Gene

Previous HGNC Symbols for ARL8A Gene

  • ARL10B

Previous GeneCards Identifiers for ARL8A Gene

  • GC01M198834
  • GC01M200368
  • GC01M173267

Summaries for ARL8A Gene

GeneCards Summary for ARL8A Gene

ARL8A (ADP-Ribosylation Factor-Like 8A) is a Protein Coding gene. GO annotations related to this gene include GTP binding and beta-tubulin binding. An important paralog of this gene is ARL1.

UniProtKB/Swiss-Prot for ARL8A Gene

  • May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity).

Gene Wiki entry for ARL8A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL8A Gene

Genomics for ARL8A Gene

Regulatory Elements for ARL8A Gene

Genomic Location for ARL8A Gene

202,133,404 bp from pter
202,144,743 bp from pter
11,340 bases
Minus strand

Genomic View for ARL8A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARL8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL8A Gene

Proteins for ARL8A Gene

  • Protein details for ARL8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP-ribosylation factor-like protein 8A
    Protein Accession:
    Secondary Accessions:
    • B3KXD0

    Protein attributes for ARL8A Gene

    186 amino acids
    Molecular mass:
    21416 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ARL8A Gene

neXtProt entry for ARL8A Gene

Proteomics data for ARL8A Gene at MOPED

Post-translational modifications for ARL8A Gene

  • Ubiquitination at Lys68 and Lys182
  • Modification sites at PhosphoSitePlus

Other Protein References for ARL8A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ARL8A Gene

Domains for ARL8A Gene

Gene Families for ARL8A Gene

  • ARF :ADP-ribosylation factors
  • ARL :ADP-ribosylation factors-like

Protein Domains for ARL8A Gene

Suggested Antigen Peptide Sequences for ARL8A Gene

Graphical View of Domain Structure for InterPro Entry



  • Q96BM9
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL8A: view

Function for ARL8A Gene

Molecular function for ARL8A Gene

UniProtKB/Swiss-Prot Function:
May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity).

Gene Ontology (GO) - Molecular Function for ARL8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 15331635
GO:0004871 signal transducer activity --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IDA 15331635
GO:0019001 guanyl nucleotide binding --
genes like me logo Genes that share ontologies with ARL8A: view

Phenotypes for ARL8A Gene

GenomeRNAi human phenotypes for ARL8A:
genes like me logo Genes that share phenotypes with ARL8A: view

Animal Model Products

miRNA for ARL8A Gene

miRTarBase miRNAs that target ARL8A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARL8A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARL8A Gene

Localization for ARL8A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL8A Gene

Late endosome membrane. Lysosome membrane.

Subcellular locations from

Jensen Localization Image for ARL8A Gene COMPARTMENTS Subcellular localization image for ARL8A gene
Compartment Confidence
cytoskeleton 5
endosome 5
lysosome 5
vacuole 5
cytosol 3
nucleus 2
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ARL8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm IDA 15331635
GO:0005765 lysosomal membrane IDA 17897319
GO:0005768 endosome --
genes like me logo Genes that share ontologies with ARL8A: view

Pathways for ARL8A Gene

SuperPathways for ARL8A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport --
GO:0007059 chromosome segregation ISS 14871887
GO:0007067 mitotic nuclear division IEA --
GO:0007186 G-protein coupled receptor signaling pathway --
genes like me logo Genes that share ontologies with ARL8A: view

No data available for Pathways by source for ARL8A Gene

Transcripts for ARL8A Gene

Unigene Clusters for ARL8A Gene

ADP-ribosylation factor-like 8A:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARL8A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL8A Gene

No ASD Table

Relevant External Links for ARL8A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARL8A Gene

mRNA expression in normal human tissues for ARL8A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ARL8A Gene

This gene is overexpressed in Nasal epithelium (8.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARL8A Gene

SOURCE GeneReport for Unigene cluster for ARL8A Gene Hs.497399

mRNA Expression by UniProt/SwissProt for ARL8A Gene

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with ARL8A: view

Expression partners for ARL8A Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ARL8A Gene

Orthologs for ARL8A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARL8A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARL8A 35
  • 92.7 (n)
  • 100 (a)
ARL8A 36
  • 99 (a)
(Mus musculus)
Mammalia Arl8a 35
  • 92.47 (n)
  • 99.46 (a)
Arl8a 16
Arl8a 36
  • 99 (a)
(Pan troglodytes)
Mammalia ARL8A 35
  • 98.1 (n)
  • 97.71 (a)
ARL8A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Arl8a 35
  • 93.01 (n)
  • 99.46 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia ARL8A 36
  • 78 (a)
(Gallus gallus)
Aves ARL8A 35
  • 88.17 (n)
  • 98.92 (a)
-- 36
  • 93 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arl8a 35
  • 81.54 (n)
  • 97.31 (a)
(Danio rerio)
Actinopterygii arl8a 35
  • 84.59 (n)
  • 97.31 (a)
arl8a 36
  • 96 (a)
fruit fly
(Drosophila melanogaster)
Insecta Gie 36
  • 87 (a)
(Caenorhabditis elegans)
Secernentea arl-8 35
  • 72.07 (n)
  • 84.86 (a)
arl-8 36
  • 85 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ARLA1D 35
  • 62.64 (n)
  • 63.74 (a)
(Oryza sativa)
Liliopsida Os03g0200800 35
  • 60.84 (n)
  • 61.75 (a)
(Triticum aestivum)
Liliopsida Ta.3262 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08618 35
  • 56.91 (n)
  • 54.14 (a)
Species with no ortholog for ARL8A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ARL8A Gene

Gene Tree for ARL8A (if available)
Gene Tree for ARL8A (if available)

Paralogs for ARL8A Gene

Paralogs for ARL8A Gene

Selected SIMAP similar genes for ARL8A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARL8A: view

Variants for ARL8A Gene

Sequence variations from dbSNP and Humsavar for ARL8A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3820382 -- 202,133,981(+) CCCCA(A/G)GTCCA utr-variant-3-prime
rs3934809 -- 202,143,771(-) AGTTT(G/T)CAGGA intron-variant
rs4342901 -- 202,134,674(+) CTCAG(A/G)TGAGA intron-variant
rs4363479 -- 202,143,157(+) TCGAG(A/G)AAGGG intron-variant
rs4950771 -- 202,142,651(+) TGGGG(G/T)GCTTT intron-variant

Relevant External Links for ARL8A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARL8A Gene

Disorders for ARL8A Gene

No disorders were found for ARL8A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ARL8A Gene

Publications for ARL8A Gene

  1. Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation. (PMID: 15331635) Okai T. … Katada T. (J. Cell Sci. 2004) 3 4 23
  2. An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility. (PMID: 16537643) Hofmann I. … Munro S. (J. Cell Sci. 2006) 3 4 23
  3. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for ARL8A Gene

  • Addgene plasmids for ARL8A

Sources for ARL8A Gene

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