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Aliases for ARL8A Gene

Aliases for ARL8A Gene

  • ADP Ribosylation Factor Like GTPase 8A 2 3 5
  • Novel Small G Protein Indispensable For Equal Chromosome Segregation 2 3 4
  • ADP-Ribosylation Factor-Like 10B 2 3
  • ADP-Ribosylation Factor-Like 8A 2 3
  • ARL10B 3 4
  • GIE2 3 4
  • ADP-Ribosylation Factor-Like Protein 10B 4
  • ADP-Ribosylation Factor-Like Protein 8A 3

External Ids for ARL8A Gene

Previous HGNC Symbols for ARL8A Gene

  • ARL10B

Previous GeneCards Identifiers for ARL8A Gene

  • GC01M198834
  • GC01M200368
  • GC01M202102
  • GC01M173267

Summaries for ARL8A Gene

GeneCards Summary for ARL8A Gene

ARL8A (ADP Ribosylation Factor Like GTPase 8A) is a Protein Coding gene. Among its related pathways are Immune System. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is ARL8B.

UniProtKB/Swiss-Prot for ARL8A Gene

  • May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity).

Gene Wiki entry for ARL8A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL8A Gene

Genomics for ARL8A Gene

Regulatory Elements for ARL8A Gene

Enhancers for ARL8A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F202233 0.8 Ensembl ENCODE 11.8 -90.6 -90622 4.1 HDGF SIN3A ZNF2 ZNF143 ZNF548 FOS ZNF263 MCM3 SP3 SMARCB1 IPO9 IPO9-AS1 ARL8A CYB5R1 RPS27P8 GPR37L1 LGR6 KDM5B PTPRVP GC01M202216
GH01F201954 0.8 ENCODE 11.7 +189.2 189223 2.5 HDGF PKNOX1 CREB3L1 ARNT MLX ARID4B SIN3A DMAP1 YBX1 ZNF2 TIMM17A IPO9 RNPEP IPO9-AS1 ARL8A GPR37L1 ENSG00000224818 ENSG00000273478 RPS27P8 GC01P201984
GH01F201911 1.2 FANTOM5 Ensembl ENCODE 11.7 +229.2 229155 7.6 HDGF ATF1 SIN3A FEZF1 ZNF48 YY1 GLIS2 ELK1 GATA2 FOS SHISA4 LMOD1 IPO9-AS1 ENSG00000223774 ARL8A RPL10P4 ENSG00000206637 RNPEP GPR37L1 IPO9
GH01F201282 1.1 Ensembl ENCODE 11.7 +857.6 857630 8.6 HDGF PKNOX1 YBX1 ZNF143 ZNF207 FOS DEK REST ZNF592 SREBF1 IPO9 IPO9-AS1 ARL8A GPR37L1 IGFN1 LAD1 ASCL5 LGR6 GC01P201285 GC01M201335
GH01F202213 0.2 ENCODE 11 -68.8 -68845 0.2 CTCF HES1 RAD21 TCF7L2 ZNF18 PTPRVP PTPN7 ARL8A LGR6 GC01M202216
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ARL8A on UCSC Golden Path with GeneCards custom track

Promoters for ARL8A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000550922 343 2401 HDGF PKNOX1 ZFP64 ARID4B SIN3A ETS1 YY1 GLIS2 ELK1 ZNF207

Genomic Location for ARL8A Gene

202,133,404 bp from pter
202,144,743 bp from pter
11,340 bases
Minus strand

Genomic View for ARL8A Gene

Genes around ARL8A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL8A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL8A Gene

Proteins for ARL8A Gene

  • Protein details for ARL8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP-ribosylation factor-like protein 8A
    Protein Accession:
    Secondary Accessions:
    • B3KXD0

    Protein attributes for ARL8A Gene

    186 amino acids
    Molecular mass:
    21416 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ARL8A Gene

neXtProt entry for ARL8A Gene

Post-translational modifications for ARL8A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARL8A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARL8A Gene

Domains & Families for ARL8A Gene

Gene Families for ARL8A Gene

Suggested Antigen Peptide Sequences for ARL8A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Arf family.
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL8A: view

Function for ARL8A Gene

Molecular function for ARL8A Gene

UniProtKB/Swiss-Prot Function:
May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity).

Gene Ontology (GO) - Molecular Function for ARL8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 15331635
GO:0005515 protein binding IPI 24955142
GO:0005525 GTP binding IEA,IDA 15331635
GO:0043014 alpha-tubulin binding ISS 15331635
GO:0048487 beta-tubulin binding ISS 15331635
genes like me logo Genes that share ontologies with ARL8A: view
genes like me logo Genes that share phenotypes with ARL8A: view

Animal Model Products

miRNA for ARL8A Gene

miRTarBase miRNAs that target ARL8A

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ARL8A

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL8A Gene

Localization for ARL8A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL8A Gene

Late endosome membrane. Lysosome membrane.

Subcellular locations from

Jensen Localization Image for ARL8A Gene COMPARTMENTS Subcellular localization image for ARL8A gene
Compartment Confidence
cytoskeleton 5
endosome 5
extracellular 5
lysosome 5
vacuole 5
cytosol 3
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ARL8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IDA 15331635
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IEA,IDA 17897319
GO:0005768 endosome IEA --
genes like me logo Genes that share ontologies with ARL8A: view

Pathways & Interactions for ARL8A Gene

SuperPathways for ARL8A Gene

SuperPathway Contained pathways
1 Immune System
genes like me logo Genes that share pathways with ARL8A: view

Pathways by source for ARL8A Gene

2 Reactome pathways for ARL8A Gene

Gene Ontology (GO) - Biological Process for ARL8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007059 chromosome segregation ISS 14871887
GO:0007067 mitotic nuclear division IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with ARL8A: view

No data available for SIGNOR curated interactions for ARL8A Gene

Transcripts for ARL8A Gene

Unigene Clusters for ARL8A Gene

ADP-ribosylation factor-like 8A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ARL8A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL8A Gene

No ASD Table

Relevant External Links for ARL8A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARL8A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARL8A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARL8A Gene

This gene is overexpressed in Nasal epithelium (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARL8A Gene

Protein tissue co-expression partners for ARL8A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARL8A Gene:


SOURCE GeneReport for Unigene cluster for ARL8A Gene:


mRNA Expression by UniProt/SwissProt for ARL8A Gene:

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with ARL8A: view

Primer Products

No data available for mRNA differential expression in normal tissues for ARL8A Gene

Orthologs for ARL8A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARL8A Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia -- 35
  • 99 (a)
(Pan troglodytes)
Mammalia ARL8A 34 35
  • 98.1 (n)
(Rattus norvegicus)
Mammalia Arl8a 34
  • 93.01 (n)
(Bos Taurus)
Mammalia ARL8A 34 35
  • 92.7 (n)
(Mus musculus)
Mammalia Arl8a 34 16 35
  • 92.47 (n)
(Ornithorhynchus anatinus)
Mammalia ARL8A 35
  • 78 (a)
(Gallus gallus)
Aves -- 35
  • 93 (a)
ARL8A 34
  • 88.17 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arl8a 34
  • 81.54 (n)
(Danio rerio)
Actinopterygii arl8a 34 35
  • 84.59 (n)
fruit fly
(Drosophila melanogaster)
Insecta Gie 35
  • 87 (a)
(Caenorhabditis elegans)
Secernentea arl-8 34 35
  • 72.07 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ARLA1D 34
  • 62.64 (n)
(Oryza sativa)
Liliopsida Os03g0200800 34
  • 60.84 (n)
(Triticum aestivum)
Liliopsida Ta.3262 34
bread mold
(Neurospora crassa)
Ascomycetes NCU08618 34
  • 56.91 (n)
Species where no ortholog for ARL8A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ARL8A Gene

Gene Tree for ARL8A (if available)
Gene Tree for ARL8A (if available)

Paralogs for ARL8A Gene

Paralogs for ARL8A Gene

(28) SIMAP similar genes for ARL8A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARL8A: view

Variants for ARL8A Gene

Sequence variations from dbSNP and Humsavar for ARL8A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10531175 -- 202,138,295(+) CCCCA(-/ACAC)ACACA intron-variant
rs10800815 -- 202,140,316(+) ttttg(G/T)atttt intron-variant
rs111812887 -- 202,141,938(+) TCTTA(A/T)CTCAC intron-variant
rs112126400 -- 202,133,952(+) CAGCC(C/T)GCACC downstream-variant-500B, utr-variant-3-prime
rs112249397 -- 202,141,936(+) ATCTT(-/AA)AACTC intron-variant

Variation tolerance for ARL8A Gene

Residual Variation Intolerance Score: 34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARL8A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARL8A Gene

Disorders for ARL8A Gene

Relevant External Links for ARL8A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARL8A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL8A Gene

Publications for ARL8A Gene

  1. An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility. (PMID: 16537643) Hofmann I. … Munro S. (J. Cell Sci. 2006) 3 4 22 64
  2. Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation. (PMID: 15331635) Okai T. … Katada T. (J. Cell Sci. 2004) 3 4 22 64
  3. Integral and associated lysosomal membrane proteins. (PMID: 17897319) Schroeder B. … Hasilik A. (Traffic 2007) 3 4 64
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ARL8A Gene

Sources for ARL8A Gene

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