Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ARL8A Gene

protein-coding   GIFtS: 50
GCID: GC01M202102

ADP-Ribosylation Factor-Like 8A

(Previous name: ADP-ribosylation factor-like 10B)
(Previous symbol: ARL10B)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
ADP-Ribosylation Factor-Like 8A1 2     GIE22 3
ARL10B1 2 3     ADP-Ribosylation Factor-Like Protein 8A2
ADP-Ribosylation Factor-Like 10B1 2     ADP-Ribosylation Factor-Like Protein 10B3
Novel Small G Protein Indispensable For Equal Chromosome Segregation 22 3     

External Ids:    HGNC: 251921   Entrez Gene: 1278292   Ensembl: ENSG000001438627   UniProtKB: Q96BM93   

Export aliases for ARL8A gene to outside databases

Previous GC identifers: GC01M198834 GC01M200368 GC01M173267


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for ARL8A Gene:
ARL8A (ADP-ribosylation factor-like 8A) is a protein-coding gene. Diseases associated with ARL8A include cervicitis. GO annotations related to this gene include GTP binding and beta-tubulin binding. An important paralog of this gene is ARL15.

UniProtKB/Swiss-Prot: ARL8A_HUMAN, Q96BM9
Function: May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By
similarity)

Gene Wiki entry for ARL8A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARL8A gene promoter:
         E2F-4   E2F-3a   E2F-1   E2F   Hand1   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARL8A promoter sequence
   Search Chromatin IP Primers for ARL8A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARL8A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

ARL8A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL8A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M202102:  view genomic region     (about GC identifiers)

Start:
202,101,977 bp from pter      End:
202,113,869 bp from pter
Size:
11,893 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ARL8A_HUMAN, Q96BM9 (See protein sequence)
Recommended Name: ADP-ribosylation factor-like protein 8A  
Size: 186 amino acids; 21416 Da
3 PDB 3D structures from and Proteopedia for ARL8A:
1ZD9 (3D)        2H18 (3D)        4ILE (3D)    
Secondary accessions: B3KXD0

Explore the universe of human proteins at neXtProt for ARL8A: NX_Q96BM9

Explore proteomics data for ARL8A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys68, Lys182
  • Modification sites at PhosphoSitePlus

  • See ARL8A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243058.1  NP_620150.1  

    ENSEMBL proteins: 
     ENSP00000272217  

    ARL8A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ARL8A
    OriGene Protein Over-expression Lysate for ARL8A
    OriGene MassSpec for ARL8A
    OriGene Custom Protein Services for ARL8A
    GenScript Custom Purified and Recombinant Proteins Services for ARL8A
    Novus Biologicals ARL8A Proteins
    Novus Biologicals ARL8A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ARL8A

    ARL8A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ARL8A
    Novus Biologicals ARL8A Antibodies
    Abcam antibodies for ARL8A
    Cloud-Clone Corp. Antibodies for ARL8A
    ThermoFisher Antibody for ARL8A
    LSBio Antibodies in human, mouse, rat for ARL8A

    ARL8A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ARL8A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ARL8A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ARL8A
    Cloud-Clone Corp. CLIAs for ARL8A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ARL: ADP-ribosylation factors-like
    ARF: ADP-ribosylation factors

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR027417 P-loop_NTPase
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF

    Graphical View of Domain Structure for InterPro Entry Q96BM9

    ProtoNet protein and cluster: Q96BM9

    1 Blocks protein domain: IPB006688 ADP-ribosylation factor

    UniProtKB/Swiss-Prot: ARL8A_HUMAN, Q96BM9
    Similarity: Belongs to the small GTPase superfamily. Arf family


    ARL8A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARL8A_HUMAN, Q96BM9
    Function: May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By
    similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity NAS15331635
    GO:0004871signal transducer activity ----
    GO:0005525GTP binding IDA15331635
    GO:0019001guanyl nucleotide binding ----
    GO:0031683G-protein beta/gamma-subunit complex binding ----
         
    ARL8A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ARL8A:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARL8A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARL8A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARL8A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARL8A

    miRNA
    Products:
        
    miRTarBase miRNAs that target ARL8A:
    hsa-mir-103a-3p (MIRT027168), hsa-mir-331-3p (MIRT019232)

    Block miRNA regulation of human, mouse, rat ARL8A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARL8A (see all 46):
    hsa-miR-4291 hsa-miR-330-5p hsa-miR-146a hsa-let-7a-2* hsa-miR-3916 hsa-miR-105 hsa-miR-1184 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidARL8A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ARL8A
    Predesigned siRNA for gene silencing in human, mouse, rat ARL8A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ARL8A

    Clone
    Products:
         
    OriGene clones in human, mouse for ARL8A (see all 7)
    OriGene ORF clones in mouse, rat for ARL8A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARL8A (NM_138795)
    Sino Biological Human cDNA Clone for ARL8A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARL8A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL8A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ARL8A
    Browse ESI BIO Cell Lines and PureStem Progenitors for ARL8A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL8A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ARL8A_HUMAN, Q96BM9: Late endosome membrane. Lysosome membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    endosome5
    lysosome5
    vacuole5
    cytosol3
    nucleus2
    plasma membrane2
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm IDA15331635
    GO:0005765lysosomal membrane IDA17897319
    GO:0030496midbody IDA15331635

    ARL8A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARL8A
    Interactions:

        Search GeneGlobe Interaction Network for ARL8A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARL8A (Q96BM93 ENSP000002722174) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP5J2P561343I2D: score=1 
    DLEU1O432613I2D: score=1 
    AHSA1ENSP000002164794STRING: ENSP00000216479
    SSR2ENSP000002957024STRING: ENSP00000295702
    ARF4ENSP000003060104STRING: ENSP00000306010
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process NAS15331635
    GO:0006886intracellular protein transport ----
    GO:0007059chromosome segregation ISS14871887
    GO:0007067mitosis IEA--
    GO:0007186G-protein coupled receptor signaling pathway ----

    ARL8A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARL8A



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ARL8A gene (2 alternative transcripts): 
    NM_001256129.1  NM_138795.3  

    Unigene Cluster for ARL8A:

    ADP-ribosylation factor-like 8A
    Hs.497399  [show with all ESTs]
    Unigene Representative Sequence: NM_138795
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000272217(uc001gxk.1) ENST00000491358 ENST00000486225
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ARL8A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARL8A (see all 46):
    hsa-miR-4291 hsa-miR-330-5p hsa-miR-146a hsa-let-7a-2* hsa-miR-3916 hsa-miR-105 hsa-miR-1184 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidARL8A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ARL8A
    Predesigned siRNA for gene silencing in human, mouse, rat ARL8A
    Clone
    Products:
         
    OriGene clones in human, mouse for ARL8A (see all 7)
    OriGene ORF clones in mouse, rat for ARL8A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARL8A (NM_138795)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARL8A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL8A
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ARL8A
    OriGene qSTAR qPCR primer pairs in human, mouse for ARL8A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARL8A
      QuantiTect SYBR Green Assays in human, mouse, rat ARL8A
      QuantiFast Probe-based Assays in human, mouse, rat ARL8A

    Additional mRNA sequence: 

    AB118752.1 AK127138.1 AK313122.1 BC015408.1 BC053358.1 BC069053.1 

    10 DOTS entries:

    DT.100022265  DT.100777524  DT.100809776  DT.100777526  DT.92428943  DT.86846604  DT.95170644  DT.95211425 
    DT.99935739  DT.92428945 

    Selected AceView cDNA sequences (see all 166):

    BQ898276 CF128459 BQ009124 AW516069 AI582546 CR597275 CA310243 AW138323 
    BC069053 BQ672070 BM999456 BG030253 AI356608 AB118752 BU149918 BC015408 
    BM980443 BF221924 AI968307 NM_138795 BM693789 AI866625 BM548962 AI597717 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ARL8A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGGTTGGT
    ARL8A Expression
    About this image


    ARL8A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Eye (Sensory Organs)
             Retina
     
     Brain (Nervous System)
             Cerebral Cortex
    ARL8A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARL8A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.497399

    UniProtKB/Swiss-Prot: ARL8A_HUMAN, Q96BM9
    Tissue specificity: Ubiquitously expressed

        Custom PCR Arrays for ARL8A
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ARL8A
    OriGene qSTAR qPCR primer pairs in human, mouse for ARL8A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARL8A
    QuantiTect SYBR Green Assays in human, mouse, rat ARL8A
    QuantiFast Probe-based Assays in human, mouse, rat ARL8A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL8A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARL8A gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arl8a1 , 5 ADP-ribosylation factor-like 8A1, 5 92.47(n)1
    99.46(a)1
      1 (58.24 cM)5
    687241  NM_026823.21  NP_081099.11 
     1351468245 
    chicken
    (Gallus gallus)
    Aves ARL8A1 ADP-ribosylation factor-like 8A 88.17(n)
    98.92(a)
      421175  NM_001012868.1  NP_001012886.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    98(a)
    many ↔ many
    4(132533452-132624497)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BC061301.12   -- 81.28(n)    BC061301.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC056568.12   -- 84.39(n)    BC056568.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gie6
    GTPase indispensable for equal segregation of chro...
    87(a)
    1 → many
    3R(3952336-3954568)
    worm
    (Caenorhabditis elegans)
    Secernentea arl-81 arl-8 72.07(n)
    84.86(a)
      178405  NM_070390.6  NP_502791.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ARLA1D1 ARLA1D 62.64(n)
    63.74(a)
      836892  NM_126156.4  NP_569051.1 
    rice
    (Oryza sativa)
    Liliopsida AK111722.12   -- 73.61(n)    AK111722.1 


    ENSEMBL Gene Tree for ARL8A (if available)
    TreeFam Gene Tree for ARL8A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ARL8A gene
    ARL152  ARL92  ARL62  ARL8B2  ARL102  ARL12  
    Selected SIMAP similar genes for ARL8A using alignment to 1 protein entry:     ARL8A_HUMAN(see all similar genes):
    ARL8B    ARL6    ARL15    ARL4A    SAR1B    ARL3
    SAR1A    ARF3    ARF5    ARL2    ARL4D    SARA1
    ARF1    ARF4    ARF6    ARL14    ARL1    ARL11

    ARL8A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ARL8A (see all 246)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1456324161,2
    --202102097(+) GGGACA/GGGGTT 2 -- int10--------
    rs585302581,2
    C--202102164(+) TGAGGC/ACTGAA 2 -- int12Minor allele frequency- A:0.12WA 120
    rs168497071,2
    C,F,H--202102378(+) AGGCCG/ATTTTG 2 -- int1 ese37Minor allele frequency- A:0.01NA NS EA 558
    rs412709671,2
    C,F--202102392(+) AGCGCC/TATTGT 2 -- int12Minor allele frequency- T:0.06WA NA 238
    rs598506711,2
    C,F--202102408(+) CCGGGC/TGGGCA 2 -- int12Minor allele frequency- T:0.04WA 120
    rs1430375691,2
    --202102539(+) CAACAC/TAAAAC 2 -- ut310--------
    rs1910519181,2
    --202102803(+) CCCTGA/GGGAGG 2 -- ut310--------
    rs75201591,2
    C,F,H--202102824(+) GGGAGC/TCAGGA 2 -- ut31 ese35Minor allele frequency- T:0.04NS EA WA 536
    rs1434110331,2
    --202102860(+) ATGGAC/TGCTGG 2 -- ut310--------
    rs1153415301,2
    C,F--202102939(+) GGGGTC/TGAGGG 2 -- ut311Minor allele frequency- T:0.09WA 118

    HapMap Linkage Disequilibrium report for ARL8A (202101977 - 202113869 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ARL8A: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARL8A
    DNA2.0 Custom Variant and Variant Library Synthesis for ARL8A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    1 disease for ARL8A:    
    About MalaCards
    cervicitis


    ARL8A for disorders           About GeneDecksing


    Export disorders for ARL8A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ARL8A gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with ARL8A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility. (PubMed id 16537643)1, 2, 9 Hofmann I. and Munro S. (J. Cell Sci. 2006)
    2. Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation. (PubMed id 15331635)1, 2, 9 Okai T.... Katada T. (J. Cell Sci. 2004)
    3. Integral and associated lysosomal membrane proteins. (PubMed id 17897319)1, 2 Schroeder B.... Hasilik A. (Traffic 2007)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1, 3 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)
    7. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 127829 HGNC: 25192 AceView: ARL10B Ensembl:ENSG00000143862 euGenes: HUgn127829
    ECgene: ARL8A H-InvDB: ARL8A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ARL8A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ARL8A gene:
    Search GeneIP for patents involving ARL8A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ARL8A  
     OriGene qPCR primer pairs and template standards for ARL8A   OriGene Protein Over-expression Lysate for ARL8A  
     OriGene MassSpec something-or-other for ARL8A   OriGene clones in human, mouse for ARL8A  
     OriGene qSTAR qPCR primer pairs in human, mouse for ARL8A   OriGene Purified Protein for ARL8A  
     OriGene ORF clones in mouse, rat for ARL8A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ARL8A   OriGene Custom Protein Services for ARL8A  

     
     
     Block miRNA regulation of human, mouse, rat ARL8A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ARL8A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARL8A Predesigned siRNA for gene silencing in human, mouse, rat ARL8A
     QuantiFast Probe-based Assays in human, mouse, rat ARL8A QuantiTect SYBR Green Assays in human, mouse, rat ARL8A
     Custom PCR Arrays for ARL8A Search Chromatin IP Primers for ARL8A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARL8A  Search GeneGlobe Interaction Network for ARL8A
     Regulatory tfbs in ARL8A promoter
     GenScript Custom Purified and Recombinant Proteins Services for ARL8A GenScript cDNA clones with any tag delivered in your preferred vector for ARL8A
     GenScript Custom Assay Services for ARL8A GenScript Custom overexpressing Cell Line Services for ARL8A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ARL8A
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for ARL8A
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ARL8A antibodies
     ARL8A proteins
     ARL8A lysates
     Antibodies for ARL8A
     See all of Abcam's Antibodies, Kits and Proteins for ARL8A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ARL8A
     Antibodies for ARL8A
     ELISAs for ARL8A
     CLIAs for ARL8A



     Browse ESI BIO Cell Lines and PureStem Progenitors for ARL8A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL8A
     SwitchGear 3'UTR luciferase reporter plasmids for ARL8A
     SwitchGear Promoter luciferase reporter plasmids for ARL8A
     ThermoFisher Antibody for ARL8A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL8A
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARL8A
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARL8A
     LSBio Antibodies in human, mouse, rat for ARL8A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ARL8A gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4