ARL8A Gene
protein-coding GIFtS : 47
GCID: GC01 M202102
ADP-ribosylation factor-like 8A (Previous name: ADP-ribosylation factor-like 10B ) (Previous symbol: ARL10B )
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Aliasesfor ARL8A gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases ADP-Ribosylation Factor-Like 8A 1 2 FLJ451951 ARL10B1 2 3 Gie21 ADP-Ribosylation Factor-Like 10B1 2 ADP-Ribosylation Factor-Like Protein 8A2 Novel Small G Protein Indispensable For Equal Chromosome Segregation 22 3 ADP-Ribosylation Factor-Like Protein 10B3 GIE22 3
Export aliases for ARL8A gene to outside databases Previous GC identifers: GC01M198834 GC01M200368 GC01M173267
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Summariesfor ARL8A gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: ARL8A_HUMAN, Q96BM9 Function : May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (Bysimilarity) Gene Wiki entry for ARL8A
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Genomic Viewsfor ARL8A gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_004487.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ARL8A gene promoter: E2F-4 E2F-3a E2F-1 E2F Hand1 E2F-2 Other transcription factors Search SABiosciences Chromatin IP Primers for ARL8A Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL8A
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1q32.1 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32.1 ARL8A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M202102: view genomic region
(about GC identifiers )
Start:
202,101,977 bp from pter
End:
202,113,869 bp from pter
Size:
11,893 bases
Orientation:
minus strand
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Proteinsfor ARL8A gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ARL8A_HUMAN, Q96BM9 (See
protein sequence )Recommended Name: ADP-ribosylation factor-like protein 8A Size : 186 amino acids; 21416 Da
Subcellular location : Late endosome membrane. Lysosome membrane
2 PDB 3D structures from and Proteopedia for ARL8A :1ZD9 (3D)
  2H18 (3D)
 
Secondary accessions : B3KXD0Explore the universe of human proteins at neXtProt for ARL8A: NX_Q96BM9 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q96BM9 ARL8A Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001243058.1 NP_620150.1 ENSEMBL proteins: ENSP00000272217 Human Recombinant Protein Products: Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view) : About this table
ARL8A for ontologies About GeneDecksing ARL8A Antibody Products: Assay Products for ARL8A:
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Protein
Domains / Familiesfor ARL8A gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ARL8A for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q96BM9 ProtoNet protein and cluster: Q96BM9
1 Blocks protein family : IPB006688 ADP-ribosylation factor UniProtKB/Swiss-Prot: ARL8A_HUMAN, Q96BM9 Similarity : Belongs to the small GTPase superfamily. Arf family
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Functionfor ARL8A gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ARL8A_HUMAN, Q96BM9 Function : May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (Bysimilarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ARL8A (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ARL8A (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ARL8A (NM_138795 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARL8A Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ARL8A
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL8A
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
ARL8A for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for ARL8A :
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Pathways & Interactionsfor ARL8A gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARL8A STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)3 Interacting proteins for ARL8A (Q96BM9 3 ENSP00000272217 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 5 biological process terms (GO ID links to tree view) : About this table
ARL8A for ontologies About GeneDecksing
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Drugs & Compoundsfor ARL8A gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for ARL8A Search CenterWatch for drugs/clinical trials and news about ARL8A
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Transcriptsfor ARL8A gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ARL8A gene (2 alternative transcripts): NM_001256129.1 NM_138795.3 Unigene Cluster for ARL8A:
ADP-ribosylation factor-like 8A Hs.497399 [show with all ESTs ] Unigene Representative Sequence: NM_138795 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000272217 (uc001gxk.1 ) ENST00000491358 ENST00000486225 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ARL8A (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ARL8A (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ARL8A (NM_138795 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARL8A Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ARL8A
Additional cDNA sequence: AB118752.1 AK127138.1 AK313122.1 BC015408.1 BC053358.1 BC069053.1
10 DOTS entries : DT.100022265 DT.100777524
DT.100809776 DT.100777526 DT.92428943 DT.86846604 DT.95170644 DT.95211425 DT.99935739 DT.92428945 24/166 AceView cDNA sequences (see all 166 ):
BQ639457 AW516069 T32205 BQ672070 AB118752 CA310243 AW138323 BU149918 BC015408 CR597275 BM999456 BF221924 BM548962 AI356608 AI968307 BG030253 NM_138795 BM693789 AI597717 BQ072223 BU738229 BM980443 CR624011 BQ898276 GeneLoc Exon Structure
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Expression for ARL8A gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ARL8A expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GGGGGTTGGT
About this image ARL8A expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Eye Retina Eye Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell Name Category Definitive endoderm-like cells (A scalable, suspensi... )
See ARL8A Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ARL8A SOURCE GeneReport for Unigene cluster: Hs.497399 UniProtKB/Swiss-Prot: ARL8A_HUMAN, Q96BM9 Tissue specificity : Ubiquitously expressed SABiosciences Custom PCR Arrays for ARL8A Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ARL8ABrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ARL8A QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ARL8A QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ARL8A In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL8A
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Orthologsfor ARL8A gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for ARL8A gene from 8/24 species (see all 24 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
ARL8A1
ADP-ribosylation factor-like 8A
88.17(n) 98.92(a)
 
421175 NM_001012868.1 NP_001012886.1
lizard (Anolis carolinensis)
Reptilia
ARL8A6
--
98(a)
1 ↔ 1
4(132567488-132624485)
tropical clawed frog (Xenopus tropicalis)
Amphibia
BC061301.12
--
81.28(n)
 
BC061301.1
zebrafish (Danio rerio)
Actinopterygii
BC056568.12
--
84.39(n)
 
BC056568.1
fruit fly (Drosophila melanogaster)
Insecta
Gie6
GTPase indispensable for equal segregation of chro...
87(a)
1 → many
3R(3952336-3954568)
worm (Caenorhabditis elegans)
Secernentea
arl-81
Protein ARL-8
72.07(n) 84.86(a)
 
178405 NM_070390.5 NP_502791.1
thale cress (Arabidopsis thaliana)
eudicotyledons
ARLA1D1
ADP-ribosylation factor-like A1D
62.64(n) 63.74(a)
 
836892 NM_126156.4 NP_569051.1
rice (Oryza sativa)
Liliopsida
AK111722.12
--
73.61(n)
 
AK111722.1
ENSEMBL Gene Tree for ARL8A (if available)TreeFam Gene Tree for ARL8A (if available)
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Paralogsfor ARL8A gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ARL8A gene ARL15 2 ARL2 2 ARL8B 2 ARL3 2 18/28 SIMAP similar genes for ARL8A using alignment to 1 protein entry: ARL8A_HUMAN (see all similar genes ):ARL8B ARL6 ARL15 ARL4A SAR1B ARF3 ARL3 SAR1A ARF5 ARL2 ARL4D SARA1 ARF1 ARF4 ARF6 ARL14 ARL1 ARL11
ARL8A for paralogs About GeneDecksing
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Genomic Variantsfor ARL8A gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ARL8A (202101977 - 202113869 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ARL8A: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ARL8A
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Disorders
/ Diseasesfor ARL8A gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section --
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Publicationsfor ARL8A gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ARL8A gene, integrated from 9 sources (see all 16 ): (articles sorted by number of sources associating them with ARL8A) Utopia : connect your pdf to the dynamic world of online information
An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility. (PubMed id 16537643) 1 , 2 , 9 Hofmann I. and Munro S. (2006) Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation. (PubMed id 15331635) 1 , 2 , 9 Okai T.... Katada T. (2004) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 1 , 2 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548) 1 , 3 Bonaldo M.F.... Soares M.B. (1996) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473) 1 Wagner S.A....Choudhary C. (2011) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007)
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External Searches for ARL8A gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ARL8A gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ARL8A gene
(According to HUGE )
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Specialized Databases showing ARL8A gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ARL8A Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ARL8A gene: Search GeneIP for patents involving ARL8A GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ARL8A gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for ARL8A OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ARL8A OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ARL8A OriGene Protein Over-expression Lysate for ARL8A Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ARL8A OriGene 3'-UTR Clone for ARL8A OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ARL8A OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ARL8A Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for ARL8A OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ARL8A OriGene Custom Protein Services for ARL8A OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARL8A QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ARL8A QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL8A QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ARL8A QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ARL8A QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ARL8A
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ARL8A Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL8A
ThermoFisher Antibody for ARL8A
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ARL8A
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Aliases for ARL8A
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