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Aliases for ARL8A Gene

Aliases for ARL8A Gene

  • ADP Ribosylation Factor Like GTPase 8A 2 3 5
  • Novel Small G Protein Indispensable For Equal Chromosome Segregation 2 3 4
  • ADP-Ribosylation Factor-Like 10B 2 3
  • ADP-Ribosylation Factor-Like 8A 2 3
  • ARL10B 3 4
  • GIE2 3 4
  • ADP-Ribosylation Factor-Like Protein 10B 4
  • ADP-Ribosylation Factor-Like Protein 8A 3

External Ids for ARL8A Gene

Previous HGNC Symbols for ARL8A Gene

  • ARL10B

Previous GeneCards Identifiers for ARL8A Gene

  • GC01M198834
  • GC01M200368
  • GC01M202102
  • GC01M173267

Summaries for ARL8A Gene

GeneCards Summary for ARL8A Gene

ARL8A (ADP Ribosylation Factor Like GTPase 8A) is a Protein Coding gene. Among its related pathways are Innate Immune System. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is ARL8B.

UniProtKB/Swiss-Prot for ARL8A Gene

  • May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity).

Gene Wiki entry for ARL8A Gene

Additional gene information for ARL8A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL8A Gene

Genomics for ARL8A Gene

Regulatory Elements for ARL8A Gene

Enhancers for ARL8A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H201954 1.2 ENCODE 11.7 +189.2 189223 2.5 HNRNPUL1 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 YBX1 ZNF2 RNPEP KDM5B ENSG00000273478 TIMM17A RPS27P8 LMOD1 ARL8A GPR37L1 LOC100506672 IPO9
GH01H201999 1 ENCODE dbSUPER 10.8 +145.0 144956 0.2 CTCF PKNOX1 ZNF2 THRB RAD21 CC2D1A POLR2A ZBTB48 SCRT2 SMC3 LMOD1 GPR37L1 TIMM17A ARL8A PTPN7 MIR6740 ENSG00000273478
GH01H202142 1.3 ENCODE dbSUPER 8.1 +0.6 588 3.2 FOXA2 PKNOX1 ZFP64 ARID4B SIN3A YY1 SP3 SP5 REST ZNF592 ENSG00000236390 LOC100506747 PTPRVP KDM5B ELF3-AS1 HNRNPA1P59 ARL8A GPR37L1 GC01P202132
GH01H202214 0.8 ENCODE dbSUPER 11.1 -68.8 -68845 0.2 CTCF RAD21 EZH2 TCF7L2 PTPRVP PTPN7 ARL8A LGR6 GC01M202216
GH01H201709 2 FANTOM5 Ensembl ENCODE dbSUPER 4.1 +431.4 431402 8.7 HDGF PKNOX1 SIN3A ZNF2 ZBTB7B ZNF143 ZNF548 FOS DEK SP3 NAV1 MIR1231 RPS27P8 ENSG00000236390 CSRP1 ENSG00000224536 PHLDA3 ENSG00000224818 ARL8A MIR5191
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARL8A on UCSC Golden Path with GeneCards custom track

Promoters for ARL8A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000018249 343 2001 FOXA2 PKNOX1 ZFP64 SIN3A YY1 ETS1 GLIS2 KLF7 ATF7 ZNF202

Genomic Locations for ARL8A Gene

Genomic Locations for ARL8A Gene
11,340 bases
Minus strand

Genomic View for ARL8A Gene

Genes around ARL8A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL8A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL8A Gene

Proteins for ARL8A Gene

  • Protein details for ARL8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP-ribosylation factor-like protein 8A
    Protein Accession:
    Secondary Accessions:
    • B3KXD0

    Protein attributes for ARL8A Gene

    186 amino acids
    Molecular mass:
    21416 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ARL8A Gene

neXtProt entry for ARL8A Gene

Post-translational modifications for ARL8A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARL8A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARL8A Gene

Domains & Families for ARL8A Gene

Gene Families for ARL8A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ARL8A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Arf family.
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL8A: view

Function for ARL8A Gene

Molecular function for ARL8A Gene

UniProtKB/Swiss-Prot Function:
May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity).

Phenotypes From GWAS Catalog for ARL8A Gene

Gene Ontology (GO) - Molecular Function for ARL8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 15331635
GO:0005515 protein binding IPI 24955142
GO:0005525 GTP binding IEA,IDA 15331635
GO:0043014 alpha-tubulin binding ISS 15331635
GO:0048487 beta-tubulin binding ISS 15331635
genes like me logo Genes that share ontologies with ARL8A: view
genes like me logo Genes that share phenotypes with ARL8A: view

miRNA for ARL8A Gene

miRTarBase miRNAs that target ARL8A

Clone Products

  • Addgene plasmids for ARL8A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL8A Gene

Localization for ARL8A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL8A Gene

Late endosome membrane. Lysosome membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL8A gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
lysosome 5
endosome 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for ARL8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IDA 15331635
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IDA,IEA 17897319
GO:0005768 endosome IEA --
genes like me logo Genes that share ontologies with ARL8A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ARL8A Gene

Pathways & Interactions for ARL8A Gene

genes like me logo Genes that share pathways with ARL8A: view

Pathways by source for ARL8A Gene

3 Reactome pathways for ARL8A Gene

Gene Ontology (GO) - Biological Process for ARL8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007059 chromosome segregation ISS 14871887
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0043312 neutrophil degranulation TAS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with ARL8A: view

No data available for SIGNOR curated interactions for ARL8A Gene

Drugs & Compounds for ARL8A Gene

No Compound Related Data Available

Transcripts for ARL8A Gene

Unigene Clusters for ARL8A Gene

ADP-ribosylation factor-like 8A:
Representative Sequences:

Clone Products

  • Addgene plasmids for ARL8A

Alternative Splicing Database (ASD) splice patterns (SP) for ARL8A Gene

No ASD Table

Relevant External Links for ARL8A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARL8A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARL8A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARL8A Gene

This gene is overexpressed in Nasal epithelium (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARL8A Gene

Protein tissue co-expression partners for ARL8A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARL8A Gene:


SOURCE GeneReport for Unigene cluster for ARL8A Gene:


mRNA Expression by UniProt/SwissProt for ARL8A Gene:

Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for ARL8A Gene

  • Nervous system(4.5)
  • Liver(4.3)
  • Muscle(2.5)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with ARL8A: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL8A Gene

Orthologs for ARL8A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARL8A Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia -- 34
  • 99 (a)
(Pan troglodytes)
Mammalia ARL8A 33 34
  • 98.1 (n)
(Rattus norvegicus)
Mammalia Arl8a 33
  • 93.01 (n)
(Bos Taurus)
Mammalia ARL8A 33 34
  • 92.7 (n)
(Mus musculus)
Mammalia Arl8a 33 16 34
  • 92.47 (n)
(Ornithorhynchus anatinus)
Mammalia ARL8A 34
  • 78 (a)
(Gallus gallus)
Aves -- 34
  • 93 (a)
ARL8A 33
  • 88.17 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arl8a 33
  • 81.54 (n)
(Danio rerio)
Actinopterygii arl8a 33 34
  • 84.59 (n)
fruit fly
(Drosophila melanogaster)
Insecta Gie 34
  • 87 (a)
(Caenorhabditis elegans)
Secernentea arl-8 33 34
  • 72.07 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ARLA1D 33
  • 62.64 (n)
(Oryza sativa)
Liliopsida Os03g0200800 33
  • 60.84 (n)
(Triticum aestivum)
Liliopsida Ta.3262 33
bread mold
(Neurospora crassa)
Ascomycetes NCU08618 33
  • 56.91 (n)
Species where no ortholog for ARL8A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ARL8A Gene

Gene Tree for ARL8A (if available)
Gene Tree for ARL8A (if available)

Paralogs for ARL8A Gene

Paralogs for ARL8A Gene

(28) SIMAP similar genes for ARL8A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARL8A: view

Variants for ARL8A Gene

Sequence variations from dbSNP and Humsavar for ARL8A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000012952 -- 202,143,583(+) ACACC(-/CAT)GGAGC intron-variant
rs1000299850 -- 202,133,299(+) CGCTC(C/T)GTGGC intron-variant, utr-variant-3-prime
rs1000415742 -- 202,133,576(+) CAAAC(A/G)GAACC utr-variant-3-prime
rs1000940744 -- 202,140,481(+) CAGGG(C/T)CTTAG intron-variant
rs1001718058 -- 202,134,700(+) AGGAG(G/T)GGAGT intron-variant

Variation tolerance for ARL8A Gene

Residual Variation Intolerance Score: 34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARL8A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARL8A Gene

Disorders for ARL8A Gene

Relevant External Links for ARL8A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARL8A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL8A Gene

Publications for ARL8A Gene

  1. An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility. (PMID: 16537643) Hofmann I … Munro S (Journal of cell science 2006) 3 4 22 60
  2. Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation. (PMID: 15331635) Okai T … Katada T (Journal of cell science 2004) 3 4 22 60
  3. Integral and associated lysosomal membrane proteins. (PMID: 17897319) Schröder B … Hasilik A (Traffic (Copenhagen, Denmark) 2007) 3 4 60
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for ARL8A Gene

  • Addgene plasmids for ARL8A

Sources for ARL8A Gene

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