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ARL6IP6 Gene

protein-coding   GIFtS: 44
GCID: GC02P153574

ADP-Ribosylation-Like Factor 6 Interacting Protein 6

  Search for ARL6IP6
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
ADP-Ribosylation-Like Factor 6 Interacting Protein 61 2     AIP-62
Phosphonoformate Immuno-Associated Protein 12 3     ADP-Ribosylation Factor-Like Protein 6-Interacting Protein 62
PFAAP12 3     Regulated By Phosphonoformate2
ARL-6-Interacting Protein 62 3     Aip-63

External Ids:    HGNC: 240481   Entrez Gene: 1511882   Ensembl: ENSG000001779177   UniProtKB: Q8N6S53   
ORGUL members:         

Export aliases for ARL6IP6 gene to outside databases

Previous GC identifers: GC02P153400 GC02P153282 GC02P145460


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ARL6IP6 Gene:
ARL6IP6 (ADP-ribosylation-like factor 6 interacting protein 6) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ARL6IP6 gene promoter:
         AML1a   CUTL1   C/EBPalpha   GATA-1   HEN1   Max   POU2F1   POU2F1c   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARL6IP6 promoter sequence
   Search Chromatin IP Primers for ARL6IP6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARL6IP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q23.3   Ensembl cytogenetic band:  2q23.3   HGNC cytogenetic band: 2q23

ARL6IP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL6IP6 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P153574:  view genomic region     (about GC identifiers)

Start:
153,574,407 bp from pter      End:
153,617,767 bp from pter
Size:
43,361 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AR6P6_HUMAN, Q8N6S5 (See protein sequence)
Recommended Name: ADP-ribosylation factor-like protein 6-interacting protein 6  
Size: 226 amino acids; 24676 Da
Secondary accessions: B2RDS6 Q7Z4G7

Explore the universe of human proteins at neXtProt for ARL6IP6: NX_Q8N6S5

Explore proteomics data for ARL6IP6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARL6IP6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689735.1  
    ENSEMBL proteins: 
     ENSP00000315357   ENSP00000399141   ENSP00000395052  

    ARL6IP6 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ARL6IP6

    ARL6IP6 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ARL6IP6
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    LSBio Antibodies in human, mouse, rat for ARL6IP6

    ARL6IP6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for ARL6IP6
    Cloud-Clone Corp. CLIAs for ARL6IP6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q8N6S5

    UniProtKB/Swiss-Prot: AR6P6_HUMAN, Q8N6S5
    Similarity: Belongs to the ARL6IP6 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    ARL6IP6 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARL6IP6
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARL6IP6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARL6IP6

    miRNA
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    miRTarBase miRNAs that target ARL6IP6:
    hsa-mir-181a-5p (MIRT025048), hsa-let-7a-5p (MIRT052420), hsa-mir-132-3p (MIRT021716), hsa-mir-142-3p (MIRT021579)

    Block miRNA regulation of human, mouse, rat ARL6IP6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARL6IP6 (see all 41):
    hsa-miR-548j hsa-let-7d hsa-miR-16-1* hsa-miR-30d hsa-let-7g hsa-miR-30a hsa-let-7a hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidARL6IP6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ARL6IP6
    Predesigned siRNA for gene silencing in human, mouse, rat ARL6IP6

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for ARL6IP6

    Clone
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    OriGene clones in human, mouse for ARL6IP6 (see all 6)
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    GenScript: all cDNA clones in your preferred vector: ARL6IP6 (NM_152522)
    Sino Biological Human cDNA Clone for ARL6IP6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARL6IP6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL6IP6

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ARL6IP6 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL6IP6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AR6P6_HUMAN, Q8N6S5: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytoskeleton1
    cytosol1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    ARL6IP6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARL6IP6
    Interactions:

        Search GeneGlobe Interaction Network for ARL6IP6

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ARL6IP6 (Q8N6S53 ENSP000003153574) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARL6Q9H0F73, ENSP000003377224I2D: score=3 STRING: ENSP00000337722
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARL6IP6 (AR6P6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARL6IP6 gene: 
    NM_152522.5  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000495469 ENST00000326446(uc002tyn.3 uc002tym.3 uc002tyo.2)
    ENST00000455875 ENST00000425034 ENST00000463690
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ARL6IP6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARL6IP6 (see all 41):
    hsa-miR-548j hsa-let-7d hsa-miR-16-1* hsa-miR-30d hsa-let-7g hsa-miR-30a hsa-let-7a hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidARL6IP6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ARL6IP6
    Predesigned siRNA for gene silencing in human, mouse, rat ARL6IP6
    Clone
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    OriGene clones in human, mouse for ARL6IP6 (see all 6)
    OriGene ORF clones in mouse, rat for ARL6IP6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARL6IP6 (NM_152522)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARL6IP6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL6IP6
    Primer
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    OriGene qPCR primer pairs and template standards for ARL6IP6
    OriGene qSTAR qPCR primer pairs in human, mouse for ARL6IP6
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ARL6IP6
      QuantiTect SYBR Green Assays in human, mouse, rat ARL6IP6
      QuantiFast Probe-based Assays in human, mouse, rat ARL6IP6

    Selected AceView cDNA sequences (see all 112):

    BQ014874 BF222824 BC070140 AI457767 BQ027456 BE672136 AW009231 AI807108 
    AI953327 AI955090 BQ009462 R38845 CD743213 CR611032 CA941829 AW235205 
    CR600798 BQ071398 AI333127 BE514712 AI453208 BF667868 AI972628 AL559195 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARL6IP6 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
    SP1:                          -     -                                                         
    SP2:                                -           -                                             
    SP3:              -     -     -     -           -                                             
    SP4:                          -     -           -                                             
    SP5:                          -     -           -     -                                       


    ECgene alternative splicing isoforms for ARL6IP6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARL6IP6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTTTTGT
    ARL6IP6 Expression
    About this image

    ARL6IP6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARL6IP6 Protein Expression
        Custom PCR Arrays for ARL6IP6
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    QuantiFast Probe-based Assays in human, mouse, rat ARL6IP6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL6IP6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ARL6IP6 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arl6ip61 , 5 ADP-ribosylation factor-like 6 interacting protein more1, 5 83.85(n)1
    83.56(a)1
      2 (30.69 cM)5
    651031  NM_022989.41  NP_075365.31 
     531917265 
    lizard
    (Anolis carolinensis)
    Reptilia ARL6IP66
    ADP-ribosylation-like factor 6 interacting protein...
    46(a)
    1 ↔ 1
    GL343296.1(1004664-1016558)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.168102 Xenopus laevis transcribed sequences 80.53(n)    48052070 
    zebrafish
    (Danio rerio)
    Actinopterygii arl6ip66
    ADP-ribosylation-like factor 6 interacting protein...
    46(a)
    1 ↔ 1
    6(13254960-13286125) ENSDARG00000071013


    ENSEMBL Gene Tree for ARL6IP6 (if available)
    TreeFam Gene Tree for ARL6IP6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARL6IP6 gene

    ARL6IP6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ARL6IP6
    PGOHUM00000249722


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARL6IP6 (see all 871)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1418766311,2
    --153575987(+) TCGCAC/TAGTCC 2 -- int10--------
    rs1462336011,2
    --153575994(+) GTCCAA/GATTTC 2 -- int10--------
    rs37489371,2
    C,F,A,H--153576006(-) CCTATG/AAAAGA 2 -- int1 trp315Minor allele frequency- A:0.33EA NA WA CSA 2010
    rs1875525881,2
    --153576258(+) GCCAAA/GTTACT 2 -- int10--------
    rs113285531,2
    C--153576265(+) TACTG-/A/AAA 
            
    AAAAA
    3 -- int1 cds1 trp32NA CSA 4
    rs50118621,2
    --153576278(+) AAAAAA/CAAAAA 2 -- int1 trp31Minor allele frequency- C:0.00NA 2
    rs75943091,2
    C--153576279(+) AAAAAC/AAAAAA 2 -- int1 trp31Minor allele frequency- A:0.50WA 2
    rs1925959731,2
    --153576409(+) CTTCCA/CAGCGT 2 -- int10--------
    rs1440389381,2
    --153576426(+) GGCTAC/TAGATG 2 -- int10--------
    rs1836961011,2
    --153576489(+) GCCAGC/TTGATG 2 -- int10--------

    HapMap Linkage Disequilibrium report for ARL6IP6 (153574407 - 153617767 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ARL6IP6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv996049CNV Insertion20482838
    nsv875293CNV Loss21882294
    nsv834421CNV Loss17160897
    esv34659CNV Loss17911159
    nsv875294CNV Gain21882294
    nsv834422CNV Gain17160897
    nsv7331OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): ARL6IP6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARL6IP6
    DNA2.0 Custom Variant and Variant Library Synthesis for ARL6IP6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    ARL6IP6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARL6IP6

    Export disorders for ARL6IP6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARL6IP6 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with ARL6IP6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    3. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    4. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (Mol. Cell 2008)
    5. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    7. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
    8. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PubMed id 17903292)4 Hwang S.J....Fox C.S. (BMC Med. Genet. 2007)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 151188 HGNC: 24048 AceView: MGC33864 Ensembl:ENSG00000177917 euGenes: HUgn151188
    ECgene: ARL6IP6 H-InvDB: ARL6IP6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARL6IP6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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