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Aliases for ARL6IP6 Gene

Aliases for ARL6IP6 Gene

  • ADP-Ribosylation Factor-Like 6 Interacting Protein 6 2 3
  • Phosphonoformate Immuno-Associated Protein 1 3 4
  • ARL-6-Interacting Protein 6 3 4
  • PFAAP1 3 4
  • AIP-6 3 4
  • ADP-Ribosylation-Like Factor 6 Interacting Protein 6 3
  • Regulated By Phosphonoformate 3

External Ids for ARL6IP6 Gene

Previous GeneCards Identifiers for ARL6IP6 Gene

  • GC02P153400
  • GC02P153282
  • GC02P153574
  • GC02P145460

Summaries for ARL6IP6 Gene

GeneCards Summary for ARL6IP6 Gene

ARL6IP6 (ADP-Ribosylation Factor-Like 6 Interacting Protein 6) is a Protein Coding gene. Diseases associated with ARL6IP6 include cutis marmorata telangiectatica congenita.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL6IP6 Gene

Genomics for ARL6IP6 Gene

Regulatory Elements for ARL6IP6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARL6IP6 Gene

Chromosome:
2
Start:
152,717,893 bp from pter
End:
152,761,253 bp from pter
Size:
43,361 bases
Orientation:
Plus strand

Genomic View for ARL6IP6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARL6IP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL6IP6 Gene

Proteins for ARL6IP6 Gene

  • Protein details for ARL6IP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6S5-AR6P6_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 6-interacting protein 6
    Protein Accession:
    Q8N6S5
    Secondary Accessions:
    • B2RDS6
    • Q7Z4G7

    Protein attributes for ARL6IP6 Gene

    Size:
    226 amino acids
    Molecular mass:
    24676 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARL6IP6 Gene

Proteomics data for ARL6IP6 Gene at MOPED

Post-translational modifications for ARL6IP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARL6IP6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARL6IP6 Gene

Domains & Families for ARL6IP6 Gene

Protein Domains for ARL6IP6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ARL6IP6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N6S5

UniProtKB/Swiss-Prot:

AR6P6_HUMAN :
  • Belongs to the ARL6IP6 family.
Family:
  • Belongs to the ARL6IP6 family.
genes like me logo Genes that share domains with ARL6IP6: view

No data available for Gene Families for ARL6IP6 Gene

Function for ARL6IP6 Gene

Gene Ontology (GO) - Molecular Function for ARL6IP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ARL6IP6: view
genes like me logo Genes that share phenotypes with ARL6IP6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARL6IP6

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL6IP6 Gene

Localization for ARL6IP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL6IP6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARL6IP6 Gene COMPARTMENTS Subcellular localization image for ARL6IP6 gene
Compartment Confidence
cytoskeleton 2
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for ARL6IP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ARL6IP6: view

Pathways & Interactions for ARL6IP6 Gene

SuperPathways for ARL6IP6 Gene

No Data Available

Interacting Proteins for ARL6IP6 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000315357%0d%0a9606.ENSP00000337722%0d%0a
Selected Interacting proteins: Q8N6S5-AR6P6_HUMAN ENSP00000315357 for ARL6IP6 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for ARL6IP6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ARL6IP6 Gene

Drugs & Compounds for ARL6IP6 Gene

No Compound Related Data Available

Transcripts for ARL6IP6 Gene

Unigene Clusters for ARL6IP6 Gene

ADP-ribosylation-like factor 6 interacting protein 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARL6IP6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL6IP6 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
SP1: - -
SP2: - -
SP3: - - - - -
SP4: - - -
SP5: - - - -
SP6: -

Relevant External Links for ARL6IP6 Gene

GeneLoc Exon Structure for
ARL6IP6
ECgene alternative splicing isoforms for
ARL6IP6

Expression for ARL6IP6 Gene

mRNA expression in normal human tissues for ARL6IP6 Gene

Protein differential expression in normal tissues from HIPED for ARL6IP6 Gene

This gene is overexpressed in Monocytes (17.7), Lung (6.9), CD8 Tcells (6.2), and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ARL6IP6 Gene



SOURCE GeneReport for Unigene cluster for ARL6IP6 Gene Hs.744874

genes like me logo Genes that share expression patterns with ARL6IP6: view

Protein tissue co-expression partners for ARL6IP6 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARL6IP6 Gene

Orthologs for ARL6IP6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ARL6IP6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARL6IP6 35
  • 86.28 (n)
  • 86.73 (a)
ARL6IP6 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARL6IP6 35
  • 81.61 (n)
  • 78.48 (a)
ARL6IP6 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arl6ip6 35
  • 83.85 (n)
  • 83.56 (a)
Arl6ip6 16
Arl6ip6 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARL6IP6 35
  • 99.56 (n)
  • 99.12 (a)
ARL6IP6 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arl6ip6 35
  • 81.98 (n)
  • 80.63 (a)
oppossum
(Monodelphis domestica)
Mammalia ARL6IP6 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARL6IP6 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arl6ip6 35
  • 60.49 (n)
  • 56.95 (a)
Str.10183 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16810 35
zebrafish
(Danio rerio)
Actinopterygii arl6ip6 36
  • 46 (a)
OneToOne
Species with no ortholog for ARL6IP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARL6IP6 Gene

ENSEMBL:
Gene Tree for ARL6IP6 (if available)
TreeFam:
Gene Tree for ARL6IP6 (if available)

Paralogs for ARL6IP6 Gene

Pseudogenes.org Pseudogenes for ARL6IP6 Gene

genes like me logo Genes that share paralogs with ARL6IP6: view

No data available for Paralogs for ARL6IP6 Gene

Variants for ARL6IP6 Gene

Sequence variations from dbSNP and Humsavar for ARL6IP6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs139485672 -- 152,723,820(+) AGAAA(A/G)GATGT intron-variant
rs139444058 -- 152,728,249(+) CCCAG(C/G)ACTTG intron-variant
rs139413387 -- 152,733,039(+) TTTAT(C/T)TCTCC intron-variant
rs139095959 -- 152,751,846(+) TACAC(A/G)TATCT intron-variant
rs138994215 -- 152,746,271(+) ATCCA(C/T)CTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARL6IP6 Gene

Variant ID Type Subtype PubMed ID
esv34659 CNV Loss 17911159
nsv7331 OTHER Inversion 18451855
nsv834421 CNV Loss 17160897
esv996049 CNV Insertion 20482838
nsv875293 CNV Loss 21882294
nsv834422 CNV Gain 17160897
nsv875294 CNV Gain 21882294

Variation tolerance for ARL6IP6 Gene

Residual Variation Intolerance Score: 58.83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.81; 34.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARL6IP6 Gene

HapMap Linkage Disequilibrium report
ARL6IP6
Human Gene Mutation Database (HGMD)
ARL6IP6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL6IP6 Gene

Disorders for ARL6IP6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARL6IP6 Gene - From: GeneCards

Disorder Aliases PubMed IDs
cutis marmorata telangiectatica congenita
  • cmtc
- elite association

Relevant External Links for ARL6IP6

Genetic Association Database (GAD)
ARL6IP6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARL6IP6
genes like me logo Genes that share disorders with ARL6IP6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARL6IP6 Gene

Publications for ARL6IP6 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. ARL6IP6, a susceptibility locus for ischemic stroke, is mutated in a patient with syndromic Cutis Marmorata Telangiectatica Congenita. (PMID: 25957586) Abumansour I.S. … Alkuraya F.S. (Hum. Genet. 2015) 67
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 67
  4. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen J.V. … Mann M. (Sci. Signal. 2010) 67
  5. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PMID: 18691976) Daub H. … Mann M. (Mol. Cell 2008) 67

Products for ARL6IP6 Gene

Sources for ARL6IP6 Gene

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