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Aliases for ARL6IP5 Gene

Aliases for ARL6IP5 Gene

  • ADP-Ribosylation Factor-Like 6 Interacting Protein 5 2 3
  • ADP-Ribosylation Factor-Like Protein 6-Interacting Protein 5 3 4
  • Cytoskeleton-Related Vitamin A-Responsive Protein 3 4
  • Glutamate Transporter EAAC1-Interacting Protein 3 4
  • Putative MAPK-Activating Protein PM27 3 4
  • Dermal Papilla-Derived Protein 11 3 4
  • Prenylated Rab Acceptor Protein 2 3 4
  • ARL-6-Interacting Protein 5 3 4
  • PRA1 Domain Family 3 2 3
  • Protein JWa 3 4
  • GTRAP3-18 3 4
  • DERP11 3 4
  • Aip-5 3 4
  • PRAF3 3 4
  • JM5 3 4
  • JWA 3 4
  • ADP-Ribosylation-Like Factor 6 Interacting Protein 5 3
  • Cytoskeleton Related Vitamin A Responsive Protein 3
  • Glutamate Transporter EEAC1-Associated Protein 3
  • Putative MAPK Activating Protein PM27 3
  • Dermal Papilla Derived Protein 11 3
  • PRA1 Family Protein 3 3
  • Addicsin 3
  • HSPC127 3
  • Hp22 3
  • PRA2 4
  • Jmx 3

External Ids for ARL6IP5 Gene

Summaries for ARL6IP5 Gene

Entrez Gene Summary for ARL6IP5 Gene

  • Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARL6IP5 Gene

ARL6IP5 (ADP-Ribosylation Factor-Like 6 Interacting Protein 5) is a Protein Coding gene. GO annotations related to this gene include protein C-terminus binding.

UniProtKB/Swiss-Prot for ARL6IP5 Gene

  • Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate. May be involved in membrane traffic (By similarity).

Gene Wiki entry for ARL6IP5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL6IP5 Gene

Genomics for ARL6IP5 Gene

Genomic Location for ARL6IP5 Gene

Start:
69,084,939 bp from pter
End:
69,106,088 bp from pter
Size:
21,150 bases
Orientation:
Plus strand

Genomic View for ARL6IP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARL6IP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL6IP5 Gene

Regulatory Elements for ARL6IP5 Gene

Proteins for ARL6IP5 Gene

  • Protein details for ARL6IP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75915-PRAF3_HUMAN
    Recommended name:
    PRA1 family protein 3
    Protein Accession:
    O75915
    Secondary Accessions:
    • B2R6V5
    • Q53ES3
    • Q5KU08

    Protein attributes for ARL6IP5 Gene

    Size:
    188 amino acids
    Molecular mass:
    21615 Da
    Quaternary structure:
    • Forms multimers. Binds to prenylated RAB1A and RAB3A, to the neuronal glutamate transporter SLC1A1/EAAC1, and to the ADP-ribosylation like factor ARL6, a member of the Ras superfamily. Does not bind to VAMP2 (By similarity).
    SequenceCaution:
    • Sequence=BAD97286.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ARL6IP5 Gene

Proteomics data for ARL6IP5 Gene at MOPED

Post-translational modifications for ARL6IP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARL6IP5 Gene

No data available for DME Specific Peptides for ARL6IP5 Gene

Domains for ARL6IP5 Gene

Protein Domains for ARL6IP5 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

PRAF3_HUMAN
Family:
  • Belongs to the PRA1 family.:
    • O75915
genes like me logo Genes that share domains with ARL6IP5: view

No data available for Gene Families for ARL6IP5 Gene

Function for ARL6IP5 Gene

Molecular function for ARL6IP5 Gene

UniProtKB/Swiss-Prot Function: Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate. May be involved in membrane traffic (By similarity).
UniProtKB/Swiss-Prot Induction: By methyl-beta-cyclodextrin (By similarity). Up-regulated upon induced differentiation and in heat stress.

Gene Ontology (GO) - Molecular Function for ARL6IP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
GO:0008022 protein C-terminus binding IEA --
genes like me logo Genes that share ontologies with ARL6IP5: view
genes like me logo Genes that share phenotypes with ARL6IP5: view

Animal Models for ARL6IP5 Gene

MGI Knock Outs for ARL6IP5:

miRNA for ARL6IP5 Gene

miRTarBase miRNAs that target ARL6IP5

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ARL6IP5 Gene

Localization for ARL6IP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL6IP5 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasm. Note=Also exists as a soluble form in the cytoplasm. Associated with microtubules (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARL6IP5 Gene COMPARTMENTS Subcellular localization image for ARL6IP5 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
extracellular 2
golgi apparatus 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ARL6IP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ARL6IP5: view

Pathways for ARL6IP5 Gene

SuperPathways for ARL6IP5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL6IP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IDA 18387645
GO:0010917 negative regulation of mitochondrial membrane potential IMP 18387645
GO:0015813 L-glutamate transport ISS --
GO:0032874 positive regulation of stress-activated MAPK cascade IMP 18387645
GO:0043065 positive regulation of apoptotic process IMP 18387645
genes like me logo Genes that share ontologies with ARL6IP5: view

No data available for Pathways by source for ARL6IP5 Gene

Compounds for ARL6IP5 Gene

(2) Novoseek inferred chemical compound relationships for ARL6IP5 Gene

Compound -log(P) Hits PubMed IDs
glutamate 49.8 9
retinoic acid 34.8 3
genes like me logo Genes that share compounds with ARL6IP5: view

Transcripts for ARL6IP5 Gene

Unigene Clusters for ARL6IP5 Gene

ADP-ribosylation-like factor 6 interacting protein 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARL6IP5 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4
SP1: - -
SP2:
SP3: -

Relevant External Links for ARL6IP5 Gene

GeneLoc Exon Structure for
ARL6IP5
ECgene alternative splicing isoforms for
ARL6IP5

Expression for ARL6IP5 Gene

mRNA expression in normal human tissues for ARL6IP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ARL6IP5 Gene

SOURCE GeneReport for Unigene cluster for ARL6IP5 Gene Hs.518060

genes like me logo Genes that share expressions with ARL6IP5: view

Orthologs for ARL6IP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARL6IP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARL6IP5 36
  • 99.65 (n)
  • 100 (a)
ARL6IP5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARL6IP5 36
  • 88.48 (n)
  • 93.62 (a)
ARL6IP5 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARL6IP5 36
  • 90.43 (n)
  • 94.68 (a)
ARL6IP5 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arl6ip5 36
  • 87.41 (n)
  • 90.43 (a)
Arl6ip5 16
Arl6ip5 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARL6IP5 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARL6IP5 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arl6ip5 36
  • 86.88 (n)
  • 92.02 (a)
chicken
(Gallus gallus)
Aves ARL6IP5 36
  • 76.95 (n)
  • 77.66 (a)
ARL6IP5 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARL6IP5 37
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arl6ip5 36
  • 70.74 (n)
  • 72.87 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10349 36
zebrafish
(Danio rerio)
Actinopterygii arl6ip5 36
arl6ip5a 36
  • 65.41 (n)
  • 65.05 (a)
arl6ip5a 37
  • 63 (a)
OneToMany
arl6ip5b 37
  • 61 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005121 36
  • 52.98 (n)
  • 38.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta Jwa 36
  • 53.33 (n)
  • 41.76 (a)
Jwa 37
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea praf-3 36
  • 46.46 (n)
  • 37.58 (a)
praf-3 37
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9659 37
  • 40 (a)
OneToMany
Species with no ortholog for ARL6IP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARL6IP5 Gene

ENSEMBL:
Gene Tree for ARL6IP5 (if available)
TreeFam:
Gene Tree for ARL6IP5 (if available)

Paralogs for ARL6IP5 Gene

genes like me logo Genes that share paralogs with ARL6IP5: view

No data available for Paralogs for ARL6IP5 Gene

Variants for ARL6IP5 Gene

Sequence variations from dbSNP and Humsavar for ARL6IP5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs7038 -- 69,104,703(+) CCTAT(G/T)TTCTG utr-variant-3-prime
rs7039 -- 69,105,192(+) ACTTC(C/G)TTTAC utr-variant-3-prime
rs10406 -- 69,105,379(+) AAAAA(A/T)AAAAC utr-variant-3-prime
rs10489 -- 69,102,001(+) CTTAT(A/C)TCCAT synonymous-codon, reference
rs937861 -- 69,094,080(+) CTGAT(G/T)CACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARL6IP5 Gene

Variant ID Type Subtype PubMed ID
nsv876933 CNV Loss 21882294
nsv876934 CNV Gain 21882294

Relevant External Links for ARL6IP5 Gene

HapMap Linkage Disequilibrium report
ARL6IP5
Human Gene Mutation Database (HGMD)
ARL6IP5

Disorders for ARL6IP5 Gene

Relevant External Links for ARL6IP5

Genetic Association Database (GAD)
ARL6IP5
Human Genome Epidemiology (HuGE) Navigator
ARL6IP5
genes like me logo Genes that share disorders with ARL6IP5: view

No data available for UniProtKB/Swiss-Prot for ARL6IP5 Gene

Publications for ARL6IP5 Gene

  1. Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18. (PMID: 11242046) Lin C.I. … Rothstein J.D. (Nature 2001) 2 3 23
  2. JM4 is a four-transmembrane protein binding to the CCR5 receptor. (PMID: 15757671) Schweneker M. … Moelling K. (FEBS Lett. 2005) 3 4 23
  3. Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2). (PMID: 16481131) Fo C.S. … Bachmann A.S. (Gene 2006) 3 4 23
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  5. Identification of addicsin/GTRAP3-18 as a chronic morphine-augumented gene in amygdala. (PMID: 12438930) Ikemoto M.J. … Ohtomi M. (NeuroReport 2002) 3 4

Products for ARL6IP5 Gene

Sources for ARL6IP5 Gene

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