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ARL6IP5 Gene

protein-coding   GIFtS: 54
GCID: GC03P069216

ADP-Ribosylation-Like Factor 6 Interacting Protein 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADP-Ribosylation-Like Factor 6 Interacting Protein 51 2     ADP-Ribosylation Factor-Like Protein 6-Interacting Protein 52 3
PRA1 Domain Family 31 2     ARL-6-Interacting Protein 52 3
Cytoskeleton-Related Vitamin A-Responsive Protein2 3     addicsin2
Dermal Papilla-Derived Protein 112 3     aip-52
Glutamate Transporter EAAC1-Interacting Protein2 3     Cytoskeleton Related Vitamin A Responsive Protein2
Prenylated Rab Acceptor Protein 22 3     Dermal Papilla Derived Protein 112
Protein JWa2 3     Glutamate Transporter EEAC1-Associated Protein2
Putative MAPK-Activating Protein PM272 3     hp222
DERP112 3     jmx2
GTRAP3-182 3     PRA1 Family Protein 32
JM52 3     Putative MAPK Activating Protein PM272
JWA2 3     Aip-53
PRAF32 3     PRA23

External Ids:    HGNC: 169371   Entrez Gene: 105502   Ensembl: ENSG000001447467   OMIM: 6057095   UniProtKB: O759153   

Export aliases for ARL6IP5 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARL6IP5 Gene:
Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the
cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat
protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is
upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport.
(provided by RefSeq, Jul 2008)

GeneCards Summary for ARL6IP5 Gene:
ARL6IP5 (ADP-ribosylation-like factor 6 interacting protein 5) is a protein-coding gene. Diseases associated with ARL6IP5 include esophageal squamous cell carcinoma, and neuronal ceroid lipofuscinosis. GO annotations related to this gene include protein C-terminus binding. An important paralog of this gene is PRAF2.

UniProtKB/Swiss-Prot: PRAF3_HUMAN, O75915
Function: Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1
glutamate transport activity by decreasing its affinity for glutamate. May be involved in membrane traffic (By
similarity)

Gene Wiki entry for ARL6IP5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARL6IP5 gene promoter:
         MEF-2A   RFX1   p53   MEF-2   aMEF-2   YY1   GATA-2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARL6IP5 promoter sequence
   Search Chromatin IP Primers for ARL6IP5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARL6IP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14   Ensembl cytogenetic band:  3p14.1   HGNC cytogenetic band: 3p14

ARL6IP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL6IP5 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P069216:  view genomic region     (about GC identifiers)

Start:
69,134,090 bp from pter      End:
69,155,239 bp from pter
Size:
21,150 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PRAF3_HUMAN, O75915 (See protein sequence)
Recommended Name: PRA1 family protein 3  
Size: 188 amino acids; 21615 Da
Subunit: Forms multimers. Binds to prenylated RAB1A and RAB3A, to the neuronal glutamate transporter SLC1A1/EAAC1,
and to the ADP-ribosylation like factor ARL6, a member of the Ras superfamily. Does not bind to VAMP2 (By
similarity)
Sequence caution: Sequence=BAD97286.1; Type=Erroneous initiation;
Secondary accessions: B2R6V5 Q53ES3 Q5KU08

Explore the universe of human proteins at neXtProt for ARL6IP5: NX_O75915

Explore proteomics data for ARL6IP5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARL6IP5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006398.1  
    ENSEMBL proteins: 
     ENSP00000273258   ENSP00000419374   ENSP00000420138   ENSP00000419021  

    ARL6IP5 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004895 Prenylated_rab_accept_PRA1

    Graphical View of Domain Structure for InterPro Entry O75915

    ProtoNet protein and cluster: O75915

    UniProtKB/Swiss-Prot: PRAF3_HUMAN, O75915
    Similarity: Belongs to the PRA1 family


    ARL6IP5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRAF3_HUMAN, O75915
    Function: Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1
    glutamate transport activity by decreasing its affinity for glutamate. May be involved in membrane traffic (By
    similarity)
    Induction: By methyl-beta-cyclodextrin (By similarity). Up-regulated upon induced differentiation and in heat
    stress

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
    GO:0008022protein C-terminus binding IEA--
         
    ARL6IP5 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Arl6ip5):
     behavior/neurological  cellular  growth/size/body  homeostasis/metabolism  immune system 
     integument  nervous system  normal  skeleton  tumorigenesis 

    ARL6IP5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Arl6ip5tm1Tnkk for ARL6IP5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARL6IP5
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARL6IP5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARL6IP5

    miRNA
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    miRTarBase miRNAs that target ARL6IP5:
    hsa-mir-155-5p (MIRT021065), hsa-mir-31-3p (MIRT038939), hsa-mir-145-5p (MIRT021502)

    Block miRNA regulation of human, mouse, rat ARL6IP5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARL6IP5 (see all 11):
    hsa-miR-3163 hsa-miR-607 hsa-miR-520d-5p hsa-miR-181a-2* hsa-miR-4282 hsa-miR-570 hsa-miR-138 hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidARL6IP5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARL6IP5

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    Sino Biological Human cDNA Clone for ARL6IP5
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL6IP5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRAF3_HUMAN, O75915: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Cytoplasm (By
    similarity). Note=Also exists as a soluble form in the cytoplasm. Associated with microtubules (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane3
    extracellular2
    golgi apparatus1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    ARL6IP5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARL6IP5
    Interactions:

        GeneGlobe Interaction Network for ARL6IP5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for ARL6IP5 (O759152, 3 ENSP000002732584) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRAF2O608312, 3, ENSP000003655704MINT-58206 MINT-58200 MINT-58205 MINT-58202 I2D: score=3 STRING: ENSP00000365570
    CCR5P516812, 3, ENSP000002923034MINT-58208 I2D: score=2 STRING: ENSP00000292303
    SLC1A1P430053, ENSP000002623524I2D: score=3 STRING: ENSP00000262352
    XRCC1P188873, ENSP000002628874I2D: score=1 STRING: ENSP00000262887
    ARL6Q9H0F73, ENSP000003377224I2D: score=3 STRING: ENSP00000337722
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008631intrinsic apoptotic signaling pathway in response to oxidative stress IDA18387645
    GO:0010917negative regulation of mitochondrial membrane potential IMP18387645
    GO:0015813L-glutamate transport ISS--
    GO:0032874positive regulation of stress-activated MAPK cascade IMP18387645
    GO:0043065positive regulation of apoptotic process IMP18387645

    ARL6IP5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARL6IP5 (PRAF3)

    2 Novoseek inferred chemical compound relationships for ARL6IP5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamate 49.8 11 12562531 (4), 17646425 (2), 11242046 (2), 15757671 (1)
    retinoic acid 34.8 4 12562531 (2), 11242046 (1)



    ARL6IP5 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARL6IP5 gene: 
    NM_006407.3  

    Unigene Cluster for ARL6IP5:

    ADP-ribosylation-like factor 6 interacting protein 5
    Hs.518060  [show with all ESTs]
    Unigene Representative Sequence: NM_006407
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273258(uc003dnr.3) ENST00000484921 ENST00000478935 ENST00000470936
    ENST00000485444
    miRNA
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    Block miRNA regulation of human, mouse, rat ARL6IP5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARL6IP5 (see all 11):
    hsa-miR-3163 hsa-miR-607 hsa-miR-520d-5p hsa-miR-181a-2* hsa-miR-4282 hsa-miR-570 hsa-miR-138 hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidARL6IP5 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ARL6IP5
      QuantiFast Probe-based Assays in human, mouse, rat ARL6IP5

    Additional mRNA sequence: 

    AB014765.1 AB052638.1 AB097051.1 AF070523.1 AF115965.1 AF125530.1 AF161476.1 AK074612.1 
    AK223566.1 AK301637.1 AK303148.1 AK312731.1 AY102608.1 BC005143.2 BC020797.1 

    Selected DOTS entries (see all 26):

    DT.91908849  DT.455983  DT.100888798  DT.100888794  DT.100888799  DT.120878674  DT.100888804  DT.120878723 
    DT.95172185  DT.100888792  DT.100888810  DT.97862271  DT.92409302  DT.100888793  DT.100888806  DT.97826315 
    DT.100888801  DT.120878687  DT.120878690  DT.120878709  DT.91679713  DT.91907694  DT.92456835  DT.95172194 

    Selected AceView cDNA sequences (see all 806):

    CR609765 AA889947 D80224 AA257039 AW444946 BP343060 BU149264 NM_006407 
    BM702082 AA721775 BQ775048 CR606544 BG540098 BE780157 BQ433571 BQ940901 
    BU579664 BI333200 BU167157 CD724143 BF000793 BE855418 AA843980 AF125530 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ARL6IP5    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4
    SP1:              -                 -         
    SP2:                                          
    SP3:              -                           


    ECgene alternative splicing isoforms for ARL6IP5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARL6IP5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTAGAATC
    ARL6IP5 Expression
    About this image


    ARL6IP5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Oviduct
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    ARL6IP5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARL6IP5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.518060
        Custom PCR Arrays for ARL6IP5
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    QuantiFast Probe-based Assays in human, mouse, rat ARL6IP5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL6IP5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARL6IP5 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arl6ip51 , 5 ADP-ribosylation factor-like 6 interacting protein more1, 5 87.41(n)1
    90.43(a)1
      6 (44.91 cM)5
    651061  NM_022992.21  NP_075368.11 
     972106895 
    chicken
    (Gallus gallus)
    Aves ARL6IP51 ADP-ribosylation-like factor 6 interacting protein more 76.95(n)
    77.66(a)
      426074  NM_001012605.1  NP_001012623.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARL6IP56
    ADP-ribosylation-like factor 6 interacting protein...
    76(a)
    1 ↔ 1
    2(182319021-182337589)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia arl6ip51 ADP-ribosylation-like factor 6 interacting protein more 70.74(n)
    72.87(a)
      100151730  NM_001127430.1  NP_001120902.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arl6ip52 ADP-ribosylation factor-like 6 interacting protein more 74.36(n)   386771  AI877919.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Jwa1 Jwa ortholog 53.33(n)
    41.76(a)
      35128  NM_136057.1  NP_609901.4 
    worm
    (Caenorhabditis elegans)
    Secernentea praf-31 praf-3 46.46(n)
    37.58(a)
      177637  NM_001027933.2  NP_001023104.1 


    ENSEMBL Gene Tree for ARL6IP5 (if available)
    TreeFam Gene Tree for ARL6IP5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARL6IP5 gene
    PRAF22  
    Selected SIMAP similar genes for ARL6IP5 using alignment to 4 protein entries:     PRAF3_HUMAN (see all proteins) (see all similar genes):
    EIF3G    pp12301    EIF3K    ZNF66    ZNF85    ARIH1
    C12orf76    HDGFRP2    TNNT1    VPS33A    ZNF211    C14orf105
    C1orf143    CALCOCO2    NDC80    SNRPF    TMX3    ZNF799

    ARL6IP5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARL6IP5 (see all 479)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1843036641,2
    --69132124(+) TGACCA/CAGATG 1 -- us2k10--------
    rs1904275321,2
    --69132128(+) CAAGAC/TGATTT 1 -- us2k10--------
    rs98347951,2
    C,F,H--69132272(+) TTAACT/GAGTGT 1 -- us2k14Minor allele frequency- G:0.01NS EA 416
    rs1150788751,2
    C,F--69132297(+) AGAAGT/CTTTGA 1 -- us2k11Minor allele frequency- C:0.02NA 120
    rs38663291,2
    C,F--69132341(+) AAAAAA/GAAAAG 1 -- us2k1 trp37Minor allele frequency- G:0.23NA WA EA 366
    rs2004544041,2
    --69132341(+) AAAAA-/GAAAAG 1 -- us2k10--------
    rs1398219331,2
    --69132399(+) AACTCA/GAAATA 1 -- us2k10--------
    rs106176661,2
    C--69132494(+) AAAGTTAG/-TAGAT 1 -- us2k1 tfbs31Minor allele frequency- -:0.50CSA 2
    rs67875691,2
    C,F,A,H--69132554(+) TAGCAA/GACAAG 1 -- us2k1 tfbs3104Minor allele frequency- G:0.25NS EA NA PA EU CA WA CSA 6330
    rs1817328731,2
    C--69132642(+) CTATAC/TATTCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARL6IP5 (69134090 - 69155239 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ARL6IP5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876933CNV Loss21882294
    nsv876934CNV Gain21882294

    Human Gene Mutation Database (HGMD): ARL6IP5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARL6IP5
    DNA2.0 Custom Variant and Variant Library Synthesis for ARL6IP5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605709    OMIM disorders: --

    14 diseases for ARL6IP5:    
    About MalaCards
    esophageal squamous cell carcinoma    neuronal ceroid lipofuscinosis    alcohol dependence    esophagitis
    squamous cell carcinoma    tonsillitis    hypertension    myeloid leukemia
    leukemia    neuronitis    malaria    cerebritis
    thyroiditis    prostatitis


    ARL6IP5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARL6IP5
    Human Genome Epidemiology (HuGE) Navigator: ARL6IP5 (5 documents)

    Export disorders for ARL6IP5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARL6IP5 gene, integrated from 10 sources (see all 60):
    (articles sorted by number of sources associating them with ARL6IP5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    2. Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18. (PubMed id 11242046)1, 3, 9 Lin C.I....Rothstein J.D. (Nature 2001)
    3. JM4 is a four-transmembrane protein binding to the CCR5 receptor. (PubMed id 15757671)1, 2, 9 Schweneker M.... Moelling K. (FEBS Lett. 2005)
    4. Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2). (PubMed id 16481131)1, 2, 9 Fo C.S.... Bachmann A.S. (Gene 2006)
    5. Functional polymorphisms of JWA gene are associated with risk of bladder cancer. (PubMed id 17479401)1, 4 Li C.P....Zhou J.W. (J. Toxicol. Environ. Health Part A 2007)
    6. Identification and functional characterization of JWA polymorphisms and their association with risk of gastric cancer and esophageal squamous cell carcinoma in a Chinese population. (PubMed id 17479402)1, 4 Tang W.Y....Zhou J.W. (J. Toxicol. Environ. Health Part A 2007)
    7. Single nucleotide polymorphism of the JWA gene is associated with risk of leukemia: a case-control study in a Chinese population. (PubMed id 17479403)1, 4 Zhu Y.J....Zhou J.W. (J. Toxicol. Environ. Health Part A 2007)
    8. [A case-control study on JWA promoter -76G--&gt;C polymorphism and the susceptibility of bladder cancer]. (PubMed id 16331563)1, 4 Wu W....Zhou J.W. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10550 HGNC: 16937 AceView: ARL6IP5 Ensembl:ENSG00000144746 euGenes: HUgn10550
    ECgene: ARL6IP5 H-InvDB: ARL6IP5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARL6IP5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARL6IP5 gene:
    Search GeneIP for patents involving ARL6IP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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