Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ARL6IP4 Gene

Aliases for ARL6IP4 Gene

  • ADP Ribosylation Factor Like GTPase 6 Interacting Protein 4 2 3 5
  • ADP-Ribosylation-Like Factor 6 Interacting Protein 4 2 3
  • ADP-Ribosylation Factor-Like 6 Interacting Protein 4 2 3
  • Splicing Factor, Arginine/Serine-Rich 20 2 3
  • ARL-6-Interacting Protein 4 3 4
  • Splicing Factor SRrp37 3 4
  • SRp25 Nuclear Protein 2 3
  • HSP-975 3 4
  • Aip-4 3 4
  • SR-15 3 4
  • SR-25 3 4
  • SRp25 3 4
  • ADP-Ribosylation Factor-Like Protein 6-Interacting Protein 4 3
  • ADP-Ribosylation Factor GTPase 6 Interacting Protein 4 3
  • Splicing Regulator SRrp38 3
  • HSVI Binding Protein 3
  • HSVI-Binding Protein 4
  • SFRS20 3
  • SRrp37 3

External Ids for ARL6IP4 Gene

Previous GeneCards Identifiers for ARL6IP4 Gene

  • GC12P122165
  • GC12P123161
  • GC12P123273
  • GC12P121902
  • GC12P121989
  • GC12P122030
  • GC12P123464
  • GC12P120426

Summaries for ARL6IP4 Gene

GeneCards Summary for ARL6IP4 Gene

ARL6IP4 (ADP Ribosylation Factor Like GTPase 6 Interacting Protein 4) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for ARL6IP4 Gene

  • Involved in modulating alternative pre-mRNA splicing with either 5 distal site activation or preferential use of 3 proximal site. In case of infection by Herpes simplex virus (HSVI), may act as a splicing inhibitor of HSVI pre-mRNA.

Gene Wiki entry for ARL6IP4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL6IP4 Gene

Genomics for ARL6IP4 Gene

Regulatory Elements for ARL6IP4 Gene

Enhancers for ARL6IP4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F123139 1.7 FANTOM5 Ensembl ENCODE 11.2 +161.9 161897 5.3 ARID4B FEZF1 DMAP1 YY1 SLC30A9 GLIS2 FOS SP3 PPARG KAT8 CDK2AP1 VPS37B ENSG00000256092 ENSG00000256028 OGFOD2 ABCB9 ARL6IP4 MPHOSPH9 HIP1R C12orf65
GH12F122085 1.4 Ensembl ENCODE 13.4 -885.6 -885577 17.2 CREB3L1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 ZCCHC8 ENSG00000272849 LINC01089 SETD1B MLXIP LOC100506691 ARL6IP4 ANAPC5 LRRC43 B3GNT4
GH12F122879 1.5 FANTOM5 ENCODE 10.1 -97.5 -97502 6.1 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 EIF2B1 VPS37B ZCCHC8 RPL27P12 IL31 LOC100506691 TMED2 MLXIP C12orf65 OGFOD2
GH12F122061 1.4 Ensembl ENCODE 10 -916.6 -916592 4.6 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 MEF2D LOC100506691 ZCCHC8 PSMD9 IL31 ENSG00000258435 ENSG00000201945 ENSG00000223538 ENSG00000256963 SETD1B ANAPC5
GH12F122365 1.4 Ensembl ENCODE 10 -612.2 -612175 4.8 ARNT ARID4B FEZF1 DMAP1 ZNF2 FOS MEF2D ZNF610 SMARCA4 ZSCAN16 SETD1B CLIP1 VPS33A ZCCHC8 MLXIP C12orf65 LINC01089 DIABLO ENSG00000252192 ENSG00000256861
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARL6IP4 on UCSC Golden Path with GeneCards custom track

Promoters for ARL6IP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000438616 840 1801 HDGF CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 ETS1 GLIS2 ELK1

Genomic Location for ARL6IP4 Gene

Chromosome:
12
Start:
122,980,060 bp from pter
End:
122,982,913 bp from pter
Size:
2,854 bases
Orientation:
Plus strand

Genomic View for ARL6IP4 Gene

Genes around ARL6IP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL6IP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL6IP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL6IP4 Gene

Proteins for ARL6IP4 Gene

  • Protein details for ARL6IP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q66PJ3-AR6P4_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 6-interacting protein 4
    Protein Accession:
    Q66PJ3
    Secondary Accessions:
    • A4UCR8
    • B3V0L0
    • B3V0L1
    • Q4F966
    • Q504R8
    • Q96BI2
    • Q9NR05
    • Q9P2R9

    Protein attributes for ARL6IP4 Gene

    Size:
    421 amino acids
    Molecular mass:
    44915 Da
    Quaternary structure:
    • Interacts with ARL6 (By similarity). Interacts with ZCCHC17. Interacts with SRSF2.
    SequenceCaution:
    • Sequence=AAF76892.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH01958.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH15569.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH15909.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH94839.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=ACF07995.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA94744.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARL6IP4 Gene

neXtProt entry for ARL6IP4 Gene

Post-translational modifications for ARL6IP4 Gene

  • Ubiquitination at Lys 347, Lys 358, Lys 383, and Lys 395
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARL6IP4 Gene

Domains & Families for ARL6IP4 Gene

Protein Domains for ARL6IP4 Gene

Suggested Antigen Peptide Sequences for ARL6IP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q66PJ3

UniProtKB/Swiss-Prot:

AR6P4_HUMAN :
  • Belongs to the ARL6IP4 family.
Family:
  • Belongs to the ARL6IP4 family.
genes like me logo Genes that share domains with ARL6IP4: view

No data available for Gene Families for ARL6IP4 Gene

Function for ARL6IP4 Gene

Molecular function for ARL6IP4 Gene

UniProtKB/Swiss-Prot Function:
Involved in modulating alternative pre-mRNA splicing with either 5 distal site activation or preferential use of 3 proximal site. In case of infection by Herpes simplex virus (HSVI), may act as a splicing inhibitor of HSVI pre-mRNA.
UniProtKB/Swiss-Prot Induction:
In case of Herpes simplex virus (HSVI)-binding to cells.

Gene Ontology (GO) - Molecular Function for ARL6IP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20098747
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ARL6IP4: view

Phenotypes for ARL6IP4 Gene

GenomeRNAi human phenotypes for ARL6IP4:
genes like me logo Genes that share phenotypes with ARL6IP4: view

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL6IP4 Gene

Localization for ARL6IP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL6IP4 Gene

Nucleus, nucleolus. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL6IP4 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for ARL6IP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10708573
GO:0005730 nucleolus IEA --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with ARL6IP4: view

Pathways & Interactions for ARL6IP4 Gene

SuperPathways for ARL6IP4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL6IP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA,TAS --
genes like me logo Genes that share ontologies with ARL6IP4: view

No data available for Pathways by source and SIGNOR curated interactions for ARL6IP4 Gene

Transcripts for ARL6IP4 Gene

mRNA/cDNA for ARL6IP4 Gene

Unigene Clusters for ARL6IP4 Gene

ADP-ribosylation-like factor 6 interacting protein 4:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL6IP4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a ·
SP1: - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - - - - - -
SP8: - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - - - -
SP11: - - -
SP12: -
SP13: - - - - - - - - - -
SP14: - - - - -
SP15: - - - -
SP16: - - -
SP17: - - - -
SP18: - - - - -
SP19: -
SP20: - - -
SP21: - -
SP22:
SP23: -
SP24:

ExUns: 10b · 10c · 10d · 10e · 10f
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:

Relevant External Links for ARL6IP4 Gene

GeneLoc Exon Structure for
ARL6IP4
ECgene alternative splicing isoforms for
ARL6IP4

Expression for ARL6IP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARL6IP4 Gene

Protein differential expression in normal tissues from HIPED for ARL6IP4 Gene

This gene is overexpressed in Adrenal (30.3) and Peripheral blood mononuclear cells (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARL6IP4 Gene



Protein tissue co-expression partners for ARL6IP4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARL6IP4 Gene:

ARL6IP4

SOURCE GeneReport for Unigene cluster for ARL6IP4 Gene:

Hs.103561

mRNA Expression by UniProt/SwissProt for ARL6IP4 Gene:

Q66PJ3-AR6P4_HUMAN
Tissue specificity: Isoforms 3 and 7 were identified in brain, pancreas, prostate, and testis, but little or no message could be detected in other tissues.
genes like me logo Genes that share expression patterns with ARL6IP4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ARL6IP4 Gene

Orthologs for ARL6IP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARL6IP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARL6IP4 34 35
  • 98.96 (n)
cow
(Bos Taurus)
Mammalia ARL6IP4 34 35
  • 88.28 (n)
mouse
(Mus musculus)
Mammalia Arl6ip4 34 16 35
  • 83.85 (n)
rat
(Rattus norvegicus)
Mammalia Arl6ip4 34
  • 83.42 (n)
dog
(Canis familiaris)
Mammalia ARL6IP4 34 35
  • 82.41 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ARL6IP4 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARL6IP4 35
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARL6IP4 35
  • 58 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii arl6ip4 35
  • 44 (a)
OneToOne
Dr.26135 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4146 34
fruit fly
(Drosophila melanogaster)
Insecta CG18428 35
  • 45 (a)
OneToOne
Species where no ortholog for ARL6IP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARL6IP4 Gene

ENSEMBL:
Gene Tree for ARL6IP4 (if available)
TreeFam:
Gene Tree for ARL6IP4 (if available)

Paralogs for ARL6IP4 Gene

(1) SIMAP similar genes for ARL6IP4 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ARL6IP4: view

No data available for Paralogs for ARL6IP4 Gene

Variants for ARL6IP4 Gene

Sequence variations from dbSNP and Humsavar for ARL6IP4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs112360219 -- 122,982,173(+) TGGTG(A/C)CTGAA intron-variant
rs112696708 -- 122,982,540(+) CAAGG(A/T)GGGTG reference, missense, splice-donor-variant
rs112854578 -- 122,981,088(+) GCCGG(A/C)CTTGG intron-variant
rs112914776 -- 122,982,539(+) ACAAG(C/G)TGGGT reference, missense, splice-donor-variant
rs114459717 -- 122,982,115(+) CTGGG(A/G)GTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARL6IP4 Gene

Variant ID Type Subtype PubMed ID
nsv914 CNV insertion 18451855
nsv560493 CNV loss 21841781
nsv560492 CNV loss 21841781
nsv517200 CNV loss 19592680
nsv455732 CNV loss 19166990
dgv22n68 CNV loss 17160897

Variation tolerance for ARL6IP4 Gene

Gene Damage Index Score: 6.00; 74.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARL6IP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARL6IP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL6IP4 Gene

Disorders for ARL6IP4 Gene

Relevant External Links for ARL6IP4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARL6IP4

No disorders were found for ARL6IP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL6IP4 Gene

Publications for ARL6IP4 Gene

  1. An SR-protein induced by HSVI binding to cells functioning as a splicing inhibitor of viral pre-mRNA. (PMID: 11884129) Li Q. … Liu L. (J. Mol. Biol. 2002) 2 3 4 64
  2. Molecular cloning and expression analysis of a putative nuclear protein, SR-25. (PMID: 10708573) Sasahara K. … Itakura M. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 64
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 64
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for ARL6IP4 Gene

Sources for ARL6IP4 Gene

Content
Loading form....