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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARL6IP4 Gene

protein-coding   GIFtS: 47
GCID: GC12P123464

ADP-ribosylation-like factor 6 interacting protein 4

 Explore 2 diseases affiliated with
ARL6IP4 via our new
 Human Malady Compendium 
Biological research products
for ARL6IP4
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
ADP-Ribosylation-Like Factor 6 Interacting Protein 41 2     HSVI-Binding Protein2 3
SR-251 2 3     ADP-Ribosylation Factor-Like Protein 6-Interacting Protein 42
SRp251 2 3     Aip-43
SFRS201 2     HSVI Binding Protein2
SRrp371 2     Splicing Factor, Arginine/Serine-Rich 202
HSP-9752 3     Splicing Regulator SRrp382
SR-152 3     SRp25 Nuclear Protein2
ARL-6-Interacting Protein 42 3     Aip-43

External Ids:    HGNC: 180761   Entrez Gene: 513292   Ensembl: ENSG000001821967   OMIM: 6076685   UniProtKB: Q66PJ33   

Export aliases for ARL6IP4 gene to outside databases

Previous GC identifers: GC12P122165 GC12P123161 GC12P123273 GC12P121902 GC12P121989 GC12P122030 GC12P120426


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: AR6P4_HUMAN, Q66PJ3
Function: In case of infection by Herpes simplex virus (HSVI), may act as a splicing inhibitor of HSVI pre-mRNA

Gene Wiki entry for ARL6IP4


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009755.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARL6IP4 gene promoter:
         Sp1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARL6IP4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARL6IP4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL6IP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

ARL6IP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL6IP4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P123464:  view genomic region     (about GC identifiers)

Start:
123,464,333 bp from pter      End:
123,467,460 bp from pter
Size:
3,128 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AR6P4_HUMAN, Q66PJ3 (See protein sequence)
Recommended Name: ADP-ribosylation factor-like protein 6-interacting protein 4  
Size: 360 amino acids; 38395 Da
Subunit: Interacts with ARL6 (By similarity)
Developmental stage: Expressed only in G1/S phase
Rna editing: Modified_positions=225; Note=Partially edited. In the brain, edited at about 7%
Sequence caution: Sequence=AAF76892.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAF76892.1; Type=Frameshift; Positions=244; Sequence=AAH01958.1; Type=Erroneous initiation;
Sequence=AAH15569.1; Type=Erroneous initiation; Sequence=BAA94744.1; Type=Erroneous initiation;
Secondary accessions: A4UCR8 Q4F966 Q504R8 Q96BI2 Q9NR05 Q9P2R9
Alternative splicing: 6 isoforms:  Q66PJ3-1   Q66PJ3-2   Q66PJ3-3   Q66PJ3-4   Q66PJ3-5   Q66PJ3-6   

Explore the universe of human proteins at neXtProt for ARL6IP4: NX_Q66PJ3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q66PJ3

  • ARL6IP4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001002251.1  NP_001002252.1  NP_057722.2  NP_061164.2  

    ENSEMBL proteins: 
     ENSP00000445309   ENSP00000442718   ENSP00000313422   ENSP00000438969   ENSP00000442200  
     ENSP00000376230   ENSP00000441406   ENSP00000406036   ENSP00000414847   ENSP00000396723  
     ENSP00000413132   ENSP00000396365   ENSP00000391598   ENSP00000350532  

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    Novus Biologicals ARL6IP4 Lysates
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    Uscn Proteins for ARL6IP4

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10708573


    ARL6IP4 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ARL6IP4 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR019532 Nucl_RNA-splicing_assoc_SR-25

    Graphical View of Domain Structure for InterPro Entry Q66PJ3

    ProtoNet protein and cluster: Q66PJ3

    UniProtKB/Swiss-Prot: AR6P4_HUMAN, Q66PJ3
    Similarity: Belongs to the ARL6IP4 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: AR6P4_HUMAN, Q66PJ3
    Function: In case of infection by Herpes simplex virus (HSVI), may act as a splicing inhibitor of HSVI pre-mRNA
    Induction: In case of Herpes simplex virus (HSVI)-binding to cells

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    Inhib. RNA
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--


    ARL6IP4 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARL6IP4

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/6 Interacting proteins for ARL6IP4 (Q66PJ31, 3 ENSP000003134224) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IKBKGQ9Y6K91, 3, ENSP000003586224EBI-2683099,EBI-356130 I2D: score=1 STRING: ENSP00000358622
    ARL6Q9H0F73, ENSP000003377224I2D: score=3 STRING: ENSP00000337722
    ETS1P149213I2D: score=1 
    FOSP011003I2D: score=1 
    STX11O755583I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008380RNA splicing TAS10708573


    ARL6IP4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ARL6IP4
    Search CenterWatch for drugs/clinical trials and news about ARL6IP4 / AR6P4 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARL6IP4 gene (4 alternative transcripts): 
    NM_001002251.1  NM_001002252.1  NM_016638.2  NM_018694.2  

    Unigene Cluster for ARL6IP4:

    ADP-ribosylation-like factor 6 interacting protein 4
    Hs.103561  [show with all ESTs]
    Unigene Representative Sequence: BM907906
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000544323 ENST00000543566 ENST00000315580(uc001ued.3) ENST00000539770
    ENST00000542099 ENST00000392435 ENST00000413381 ENST00000426960 ENST00000453766(uc001uec.3 uc001uee.3 uc001ueg.3 uc001uei.3)
    ENST00000454885(uc009zxt.3) ENST00000539576 ENST00000442210 ENST00000412505
    ENST00000540708 ENST00000536502 ENST00000540382 ENST00000439686 ENST00000392433


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    hsa-miR-4271
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    Inhib. RNA
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    Additional cDNA sequence: 

    AB035384.1 AF267748.1 AK315759.1 BC001958.1 BC015569.2 BC015909.1 BC094839.1 DQ099385.1 
    EF036485.1 EU624490.1 EU624491.1 

    24/38 DOTS entries (see all 38):

    DT.455815  DT.100667623  DT.99996054  DT.97860690  DT.75114915  DT.100667608  DT.100842040  DT.100856913 
    DT.92445018  DT.100807989  DT.100667620  DT.100730966  DT.100667613  DT.100772752  DT.100802813  DT.95087149 
    DT.95087153  DT.100031635  DT.100667621  DT.100848747  DT.121179386  DT.92415351  DT.92445015  DT.97860698 

    5 AceView cDNA sequences:

    NM_001002252 BG109619 NM_018694 NM_016638 NM_001002251 

    GeneLoc Exon Structure

    5/24 Alternative Splicing Database (ASD) splice patterns (SP) for ARL6IP4 (see all 24)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a ·
    SP1:                                                  -     -     -     -                       -                                         -                     
    SP2:                                                  -     -     -     -                       -     -                 -     -           -                     
    SP3:                                                  -     -     -     -                 -     -                                         -                     
    SP4:                                                        -     -     -                 -     -                       -     -           -                     
    SP5:                                                        -     -     -                 -     -                                         -                     

    ExUns: 10b · 10c · 10d · 10e · 10f
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for ARL6IP4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARL6IP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCAAGGAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ARL6IP4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARL6IP4

    SOURCE GeneReport for Unigene cluster: Hs.103561
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ARL6IP4 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arl6ip41 , 5 ADP-ribosylation factor-like 6 interacting protein more1, 5 84.67(n)1
    85.71(a)1
      5 (63.39 cM)5
    651051  NM_144509.21  NP_653092.11 
     1241160895 
    chicken
    (Gallus gallus)
    Aves ARL6IP41 ADP-ribosylation-like factor 6 interacting protein more 66.37(n)
    65.32(a)
      427695  NM_001031470.1  NP_001026641.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARL6IP46
    --
    55(a)
    1 ↔ 1
    LGb(2017170-2021336)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.261352 Transcribed sequence with weak similarity to protein more 77.29(n)    BM530019.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG184281 CG18428 57.67(n)
    54.76(a)
      42857  NM_142956.2  NP_651213.1 


    ENSEMBL Gene Tree for ARL6IP4 (if available)
    TreeFam Gene Tree for ARL6IP4 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARL6IP4 gene
    1 SIMAP similar gene for ARL6IP4 using alignment to 8 protein entries:     AR6P4_HUMAN (see all proteins):
    FLJ00169

    ARL6IP4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ARL6IP4
    PGOHUM00000258690


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/88 NCBI SNPs in ARL6IP4 are shown (see all 88    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1177725291,2
    C,F,--123462949(+) GCCCAC/TGGCCA 5 -- int1 us2k11Minor allele frequency- T:0.03EA 120
    rs606418611,2
    C,F,--123462962(+) TTCAGG/ACCAAC 5 -- int1 us2k13Minor allele frequency- A:0.01WA EU 1423
    rs2018651281,2
    --123463134(+) TGGCCA/GGTGGC 5 -- us2k1 int10--------
    rs2006662981,2
    --123463148(+) GGAGGA/GGGTGG 5 -- int1 us2k10--------
    rs1843380171,2
    --123463199(+) TGCCTG/TCCCGG 5 -- int1 us2k10--------
    rs2004824381,2
    --123463600(+) TGTGAG/TTGCCC 5 -- us2k1 int10--------
    rs1890820921,2
    C,--123463908(+) GGCCCA/GGTGTG 5 -- us2k1 ut310--------
    rs615462411,2
    C,F,--123463999(+) CTCAAC/GGGTGT 5 -- ut31 us2k14Minor allele frequency- G:0.17WA CSA 123
    rs1810266641,2
    --123464262(+) TGAATA/GACTTC 5 -- ut31 us2k10--------
    rs1856622151,2
    --123464275(+) AGACAC/TTTATC 5 -- ut31 us2k10--------

    HapMap Linkage Disequilibrium report for ARL6IP4 (123464333 - 123467460 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for ARL6IP4
         3 CNVs: 48972 4790 48973

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ARL6IP4 for disorders           About GeneDecksing

    OMIM gene information: 607668    OMIM disorders: --

    2 diseases for ARL6IP4:    About MalaCards
    herpes simplex    melanoma


    Export disorders for ARL6IP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARL6IP4 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with ARL6IP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An SR-protein induced by HSVI binding to cells functioning as a splicing inhibitor of viral pre-mRNA. (PubMed id 11884129)1, 2, 3 Li Q.... Liu L. (2002)
    2. Molecular cloning and expression analysis of a putative nuclear protein, SR-25. (PubMed id 10708573)1, 2, 3 Sasahara K.... Itakura M. (2000)
    3. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    6. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    7. Expanding the substantial interactome of NEMO using p rotein microarrays. (PubMed id 20098747)1 Fenner B.J....Prehn J.H. (2010)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    9. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
    10. Screening of human SNP database identifies recoding sites of A-to-I RNA editing. (PubMed id 18772245)2 Gommans W.M.... Maas S. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51329 HGNC: 18076 AceView: ARL6IP4 Ensembl:ENSG00000182196 euGenes: HUgn51329
    ECgene: ARL6IP4 H-InvDB: ARL6IP4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARL6IP4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARL6IP4 gene:
    Search GeneIP for patents involving ARL6IP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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