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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARL6IP1 Gene

protein-coding   GIFtS: 50
GCID: GC16M018802

ADP-ribosylation factor-like 6 interacting protein 1

(Previous name: ADP-ribosylation factor-like 6 interacting protein )
(Previous symbol: ARL6IP)
 Explore 5 diseases affiliated with
ARL6IP1 via our new
 Human Malady Compendium 
Biological research products
for ARL6IP1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
ADP-Ribosylation Factor-Like 6 Interacting Protein 11 2     ADP-Ribosylation Factor-Like 6 Interacting Protein1
ARL6IP1 2 3 5     ADP-Ribosylation Factor-Like Protein 6-Interacting Protein 12
KIAA00691 3 5     Aip-13
AIP11 2     Apoptotic Regulator In The Membrane Of The Endoplasmic Reticulum2
ARMER1 2     Aip-13
ARL-6-Interacting Protein 12 3     

External Ids:    HGNC: 6971   Entrez Gene: 232042   Ensembl: ENSG000001705407   OMIM: 6076695   UniProtKB: Q150413   

Export aliases for ARL6IP1 gene to outside databases

Previous GC identifers: GC16M018711 GC16M017345


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: AR6P1_HUMAN, Q15041
Function: May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation

Gene Wiki entry for ARL6IP1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARL6IP1 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-2   Tal-1beta   E47   YY1   E2F   E2F-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARL6IP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARL6IP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL6IP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12-p11.2   Ensembl cytogenetic band:  16p12.3   HGNC cytogenetic band: 16p12-p11.2

ARL6IP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL6IP1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M018802:  view genomic region     (about GC identifiers)

Start:
18,802,991 bp from pter      End:
18,813,000 bp from pter
Size:
10,010 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AR6P1_HUMAN, Q15041 (See protein sequence)
Recommended Name: ADP-ribosylation factor-like protein 6-interacting protein 1  
Size: 203 amino acids; 23363 Da
Subunit: Interacts with ARL6 (By similarity)
Subcellular location: Endomembrane system; Multi-pass membrane protein. Note=Predominantly localized to
intracytoplasmic membranes
Developmental stage: Down-regulated during myeloid differentiation
Sequence caution: Sequence=BAA06683.1; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for ARL6IP1: NX_Q15041

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15041

  • ARL6IP1 Protein expression data from MOPED and PaxDb:    About this image 
    ARL6IP1 Protein Expression
    REFSEQ proteins: NP_055976.1  
    ENSEMBL proteins: 
     ENSP00000306788   ENSP00000456596   ENSP00000440048   ENSP00000457372   ENSP00000455341  

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    Uscn Proteins for ARL6IP1

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005783endoplasmic reticulum IDA--
    GO:0005784Sec61 translocon complex IEA--
    GO:0005829cytosol IEA--
    GO:0012505endomembrane system ----

    ARL6IP1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ARL6IP1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR003388 Reticulon

    Graphical View of Domain Structure for InterPro Entry Q15041

    ProtoNet protein and cluster: Q15041

    UniProtKB/Swiss-Prot: AR6P1_HUMAN, Q15041
    Similarity: Belongs to the ARL6ip family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AR6P1_HUMAN, Q15041
    Function: May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19060904
         
    ARL6IP1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ARL6IP1 

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    SwitchGear 3'UTR luciferase reporter plasmidARL6IP1 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL6IP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARL6IP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/18 Interacting proteins for ARL6IP1 (Q150411, 2, 3 ENSP000003067884) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FXR2P511161, 2, 3, ENSP000002501134EBI-714543,EBI-740459 MINT-67910 I2D: score=5 STRING: ENSP00000250113
    INPP5KQ9BT402, 3, ENSP000002547124MINT-67457 I2D: score=5 STRING: ENSP00000254712
    HMGCLP359142, 3, ENSP000003636144MINT-8258175 I2D: score=2 STRING: ENSP00000363614
    FDFT1P372682, 3MINT-64198 I2D: score=5 
    NUDT3O959892, 3MINT-8264638 I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006613cotranslational protein targeting to membrane IEA--

    ARL6IP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARL6IP1
    Search CenterWatch for drugs/clinical trials and news about ARL6IP1 / AR6P1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARL6IP1 gene: 
    NM_015161.1  

    Unigene Cluster for ARL6IP1:

    ADP-ribosylation factor-like 6 interacting protein 1
    Hs.634882  [show with all ESTs]
    Unigene Representative Sequence: BC010281
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304414(uc010van.1 uc002dfl.1 uc010bvz.1) ENST00000563861
    ENST00000546206 ENST00000562819 ENST00000562234 ENST00000569976 ENST00000567969
    ENST00000566391

    miRNA
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    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate ARL6IP1 (see all 35):
    hsa-miR-328 hsa-miR-301a hsa-miR-1244 hsa-miR-3658 hsa-miR-3613-3p hsa-miR-23a hsa-miR-130b hsa-miR-301b
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARL6IP1 (see all 7)
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    Additional cDNA sequence: 

    AK291137.1 AK300825.1 AK300869.1 AK301636.1 AK307315.1 AK308092.1 AK308744.1 BC010281.1 
    BX648446.1 D31885.1 

    24/46 DOTS entries (see all 46):

    DT.100688565  DT.85104784  DT.100688547  DT.97860414  DT.95085005  DT.99954535  DT.100052005  DT.100640157 
    DT.100688560  DT.95085060  DT.95084950  DT.100688564  DT.120668717  DT.120668665  DT.100760637  DT.92415616 
    DT.92462781  DT.100688559  DT.100871273  DT.120668615  DT.100688553  DT.100688557  DT.100688558  DT.120668644 

    24/947 AceView cDNA sequences (see all 947):

    AU132094 BM748201 BE788626 AI076857 AA314834 BQ423201 BU521202 BQ647892 
    AI198549 BG340466 AA894651 BU674745 BM974471 BP373989 BQ051667 BM828975 
    BM090953 BU957349 AK023088 AU142725 BM786268 BU173158 BM856113 BM424111 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ARL6IP1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b
    SP1:                                -                 -           -                     
    SP2:                                -                 -                                 
    SP3:                                -                 -     -     -     -               
    SP4:                                -                                                   
    SP5:                                                                                    


    ECgene alternative splicing isoforms for ARL6IP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARL6IP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAGATAGTG
    ARL6IP1 Expression
    About this image
    See ARL6IP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARL6IP1

    SOURCE GeneReport for Unigene cluster: Hs.634882

    UniProtKB/Swiss-Prot: AR6P1_HUMAN, Q15041
    Tissue specificity: Expressed in all hematopoietic cell lineages, but the highest level of expression is found in early
    myeloid progenitor cells. Expressed in brain, bone marrow, thymus and lung. Expressed at low level in liver, kidney
    and spleen. Not detected in heart

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ARL6IP1 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arl6ip11 , 5 ADP-ribosylation factor-like 6 interacting protein more1, 5 91.3(n)1
    96.55(a)1
      7 (63.44 cM)5
    542081  NM_019419.21  NP_062292.11 
     1181188915 
    chicken
    (Gallus gallus)
    Aves ARL6IP11 ADP-ribosylation factor-like 6 interacting protein more 78.82(n)
    86.21(a)
      416604  NM_001006171.1  NP_001006171.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARL6IP16
    --
    85(a)
    1 → many
    GL343769.1(50126-66055)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.231612 Xenopus laevis transcribed sequence with moderate similarity more 76.75(n)    CF548200.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc565932 similar to ADP-ribosylation factor-like 6 interacting more 77.86(n)   394087  BC062864.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG103261 CG10326 44.75(n)
    29.28(a)
      42027  NM_142313.2  NP_650570.1 


    ENSEMBL Gene Tree for ARL6IP1 (if available)
    TreeFam Gene Tree for ARL6IP1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARL6IP1 gene
    ENSG000002603422  

    ARL6IP1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for ARL6IP1
    PGOHUM00000258514 PGOHUM00000258573 PGOHUM00000262888


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/186 NCBI SNPs in ARL6IP1 are shown (see all 186    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs559344641,2
    C--18803664(+) CTGGTC/TTCAAA 1 -- ut310--------
    rs1459424091,2
    --18803870(+) AAAAGC/GCTTTA 1 -- ut310--------
    rs1897054101,2
    --18803891(+) AACTTC/TGAGTC 1 -- ut310--------
    rs1481115151,2
    C--18803912(+) GGGACG/AAAAGC 1 -- ut311Minor allele frequency- A:0.01NS 150
    rs1856127411,2
    --18803936(+) ACATTC/GCTTTT 1 -- ut310--------
    rs1397885521,2
    --18804058(+) TCCCAC/TTGGAA 1 -- ut310--------
    rs1431610971,2
    --18804098(+) GGTCTC/GTTCAT 1 -- ut310--------
    rs1507031991,2
    --18804134(+) ATTCAC/GGAAGT 1 -- ut310--------
    rs1399694801,2
    --18804135(+) TTCACA/GAAGTC 1 -- ut310--------
    rs1498322331,2
    --18804163(+) GACTGC/TGGAAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ARL6IP1 (18802991 - 18813000 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for ARL6IP1
         3 CNVs: 3994 8816 3112

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ARL6IP1 for disorders           About GeneDecksing

    OMIM gene information: 607669    OMIM disorders: --

    5 diseases for ARL6IP1:    About MalaCards
    microphthalmia    cervical cancer    cervicitis    nasopharyngitis
    carcinoma

    Human Genome Epidemiology (HuGE) Navigator: ARL6IP1 (1 document)

    Export disorders for ARL6IP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARL6IP1 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with ARL6IP1)
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    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Characterization, chromosomal localization, and expression during hematopoietic differentiation of the gene encoding Arl6ip, ADP- ribosylation-like factor-6 interacting protein (ARL6). (PubMed id 10995579)1, 2 Pettersson M.... Jonsson J.I. (2000)
    3. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2 Nomura N....Tabata S. (1994)
    4. ARL6IP1 mediates cisplatin-induced apoptosis in CaSki cervical cancer cells. (PubMed id 20372863)1, 9 Guo F....Li G. (2010)
    5. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23204 HGNC: 697 AceView: RPS15AandARL6IP Ensembl:ENSG00000170540 euGenes: HUgn23204
    ECgene: ARL6IP1 H-InvDB: ARL6IP1

    (According to HUGE)
    About This Section
    HUGE: KIAA0069

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARL6IP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARL6IP1 gene:
    Search GeneIP for patents involving ARL6IP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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