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ARL6IP1 Gene

protein-coding   GIFtS: 52
GCID: GC16M018802

ADP-Ribosylation Factor-Like 6 Interacting Protein 1

(Previous name: ADP-ribosylation factor-like 6 interacting protein)
(Previous symbol: ARL6IP)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADP-Ribosylation Factor-Like 6 Interacting Protein 11 2     AIP12
ARL6IP1 2 3 5     ARMER2
ARL-6-Interacting Protein 12 3     ADP-Ribosylation Factor-Like Protein 6-Interacting Protein 12
SPG612 5     aip-12
KIAA00693 5     Apoptotic Regulator In The Membrane Of The Endoplasmic Reticulum2
ADP-Ribosylation Factor-Like 6 Interacting Protein1     Aip-13

External Ids:    HGNC: 6971   Entrez Gene: 232042   Ensembl: ENSG000001705407   OMIM: 6076695   UniProtKB: Q150413   

Export aliases for ARL6IP1 gene to outside databases

Previous GC identifers: GC16M018711 GC16M017345


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ARL6IP1 Gene:
ARL6IP1 (ADP-ribosylation factor-like 6 interacting protein 1) is a protein-coding gene. Diseases associated with ARL6IP1 include microphthalmia, and nasopharyngitis. An important paralog of this gene is ENSG00000260342.

UniProtKB/Swiss-Prot: AR6P1_HUMAN, Q15041
Function: May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic
maturation

Gene Wiki entry for ARL6IP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARL6IP1 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-2   Tal-1beta   E47   YY1   E2F   E2F-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARL6IP1 promoter sequence
   Search Chromatin IP Primers for ARL6IP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARL6IP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12-p11.2   Ensembl cytogenetic band:  16p12.3   HGNC cytogenetic band: 16p12-p11.2

ARL6IP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL6IP1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M018802:  view genomic region     (about GC identifiers)

Start:
18,802,991 bp from pter      End:
18,813,000 bp from pter
Size:
10,010 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: AR6P1_HUMAN, Q15041 (See protein sequence)
Recommended Name: ADP-ribosylation factor-like protein 6-interacting protein 1  
Size: 203 amino acids; 23363 Da
Subunit: Interacts with ARL6 (By similarity)
Developmental stage: Down-regulated during myeloid differentiation
Sequence caution: Sequence=BAA06683.1; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for ARL6IP1: NX_Q15041

Explore proteomics data for ARL6IP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys96, Lys114, Lys124
  • Modification sites at PhosphoSitePlus

  • See ARL6IP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055976.1  
    ENSEMBL proteins: 
     ENSP00000306788   ENSP00000456596   ENSP00000440048   ENSP00000457372   ENSP00000455341  

    ARL6IP1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003388 Reticulon

    Graphical View of Domain Structure for InterPro Entry Q15041

    ProtoNet protein and cluster: Q15041

    UniProtKB/Swiss-Prot: AR6P1_HUMAN, Q15041
    Similarity: Belongs to the ARL6ip family


    ARL6IP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AR6P1_HUMAN, Q15041
    Function: May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic
    maturation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    ARL6IP1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARL6IP1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARL6IP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARL6IP1

    miRNA
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    miRTarBase miRNAs that target ARL6IP1:
    hsa-mir-130b-3p (MIRT020234), hsa-mir-133a-3p (MIRT021699), hsa-let-7b-5p (MIRT052297), hsa-mir-19b-3p (MIRT031123), hsa-mir-1229-3p (MIRT036368), hsa-let-7c-5p (MIRT051826), hsa-mir-877-3p (MIRT036888), hsa-mir-27a-3p (MIRT028699), hsa-mir-423-5p (MIRT038159), hsa-let-7f-5p (MIRT051371)

    Block miRNA regulation of human, mouse, rat ARL6IP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARL6IP1 (see all 35):
    hsa-miR-328 hsa-miR-301a hsa-miR-1244 hsa-miR-3658 hsa-miR-3613-3p hsa-miR-23a hsa-miR-130b hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmidARL6IP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARL6IP1

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    GenScript: all cDNA clones in your preferred vector: ARL6IP1 (NM_015161)
    Sino Biological Human cDNA Clone for ARL6IP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARL6IP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL6IP1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL6IP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AR6P1_HUMAN, Q15041: Endomembrane system; Multi-pass membrane protein. Note=Predominantly localized to
    intracytoplasmic membranes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    plasma membrane3
    cytosol2
    peroxisome2
    golgi apparatus1
    lysosome1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005783endoplasmic reticulum ----
    GO:0005784Sec61 translocon complex IEA--
    GO:0005829cytosol IEA--
    GO:0016021integral component of membrane IEA--

    ARL6IP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ARL6IP1
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    PTEN Pathway
    Epithelial Adherens Junctions



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARL6IP1
    Interactions:

        Search GeneGlobe Interaction Network for ARL6IP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for ARL6IP1 (Q150411, 2, 3 ENSP000003067884) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FXR2P511161, 2, 3, ENSP000002501134EBI-714543,EBI-740459 MINT-67910 I2D: score=5 STRING: ENSP00000250113
    INPP5KQ9BT402, 3, ENSP000002547124MINT-67457 I2D: score=5 STRING: ENSP00000254712
    HMGCLP359142, 3, ENSP000003636144MINT-8258175 I2D: score=2 STRING: ENSP00000363614
    FDFT1P372682, 3MINT-64198 I2D: score=5 
    NUDT3O959892, 3MINT-8264638 I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006613cotranslational protein targeting to membrane IEA--

    ARL6IP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARL6IP1 (AR6P1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARL6IP1 gene: 
    NM_015161.1  

    Unigene Cluster for ARL6IP1:

    ADP-ribosylation factor-like 6 interacting protein 1
    Hs.634882  [show with all ESTs]
    Unigene Representative Sequence: BC010281
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304414(uc010van.1 uc002dfl.1 uc010bvz.1) ENST00000563861
    ENST00000546206 ENST00000562819 ENST00000562234 ENST00000569976 ENST00000567969
    ENST00000566391
    miRNA
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    Block miRNA regulation of human, mouse, rat ARL6IP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARL6IP1 (see all 35):
    hsa-miR-328 hsa-miR-301a hsa-miR-1244 hsa-miR-3658 hsa-miR-3613-3p hsa-miR-23a hsa-miR-130b hsa-miR-301b
    SwitchGear 3'UTR luciferase reporter plasmidARL6IP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ARL6IP1
    Predesigned siRNA for gene silencing in human, mouse, rat ARL6IP1
    Clone
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    OriGene ORF clones in mouse, rat for ARL6IP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARL6IP1 (NM_015161)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARL6IP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL6IP1
    Primer
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    OriGene qPCR primer pairs and template standards for ARL6IP1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARL6IP1
      QuantiTect SYBR Green Assays in human, mouse, rat ARL6IP1
      QuantiFast Probe-based Assays in human, mouse, rat ARL6IP1

    Additional mRNA sequence: 

    AK291137.1 AK300825.1 AK300869.1 AK301636.1 AK307315.1 AK308092.1 AK308744.1 BC010281.1 
    BX648446.1 D31885.1 

    Selected DOTS entries (see all 50):

    DT.100688565  DT.85104784  DT.100688547  DT.97860414  DT.95085005  DT.99954535  DT.100052005  DT.100640157 
    DT.100688560  DT.95084950  DT.95085060  DT.100688564  DT.120668717  DT.120668665  DT.100760637  DT.100718699 
    DT.92415616  DT.92462781  DT.100688559  DT.100871273  DT.120668615  DT.100688553  DT.100688558  DT.120668644 

    Selected AceView cDNA sequences (see all 947):

    BG034026 AJ713611 BP382911 BQ349090 AA669280 BM828034 BG178906 BE349126 
    AA327664 BM832708 AW273036 BE733322 AI565826 BU624254 BX488101 Z40172 
    AI093472 AL119666 CD358958 D31244 AI086887 BQ929778 BI850540 AI281400 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARL6IP1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b
    SP1:                                -                 -           -                     
    SP2:                                -                 -                                 
    SP3:                                -                 -     -     -     -               
    SP4:                                -                                                   
    SP5:                                                                                    


    ECgene alternative splicing isoforms for ARL6IP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARL6IP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGATAGTG
    ARL6IP1 Expression
    About this image


    ARL6IP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    ARL6IP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARL6IP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.634882

    UniProtKB/Swiss-Prot: AR6P1_HUMAN, Q15041
    Tissue specificity: Expressed in all hematopoietic cell lineages, but the highest level of expression is found in
    early myeloid progenitor cells. Expressed in brain, bone marrow, thymus and lung. Expressed at low level in
    liver, kidney and spleen. Not detected in heart

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    OriGene qSTAR qPCR primer pairs in human, mouse for ARL6IP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARL6IP1
    QuantiTect SYBR Green Assays in human, mouse, rat ARL6IP1
    QuantiFast Probe-based Assays in human, mouse, rat ARL6IP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL6IP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARL6IP1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arl6ip11 , 5 ADP-ribosylation factor-like 6 interacting protein more1, 5 91.3(n)1
    96.55(a)1
      7 (63.44 cM)5
    542081  NM_019419.21  NP_062292.11 
     1181188915 
    chicken
    (Gallus gallus)
    Aves ARL6IP11 ADP-ribosylation factor-like 6 interacting protein more 78.82(n)
    86.21(a)
      416604  NM_001006171.1  NP_001006171.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    85(a)
    1 → many
    GL343769.1(50126-66055)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.231612 Xenopus laevis transcribed sequence with moderate similarity more 76.75(n)    CF548200.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc565932 similar to ADP-ribosylation factor-like 6 interacting more 77.86(n)   394087  BC062864.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG103261 CG10326 44.57(n)
    29.28(a)
      42027  NM_001275718.1  NP_001262647.1 


    ENSEMBL Gene Tree for ARL6IP1 (if available)
    TreeFam Gene Tree for ARL6IP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARL6IP1 gene
    ENSG000002603422  

    ARL6IP1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for ARL6IP1
    PGOHUM00000258514 PGOHUM00000258573 PGOHUM00000262888


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARL6IP1 (see all 231)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs559344641,2
    C--18803664(+) CTGGTC/TTCAAA 1 -- ut310--------
    rs1459424091,2
    C--18803870(+) AAAAGC/GCTTTA 1 -- ut310--------
    rs1897054101,2
    --18803891(+) AACTTC/TGAGTC 1 -- ut310--------
    rs1481115151,2
    C--18803912(+) GGGACG/AAAAGC 1 -- ut311Minor allele frequency- A:0.01NS 150
    rs1856127411,2
    --18803936(+) ACATTC/GCTTTT 1 -- ut310--------
    rs1397885521,2
    C--18804058(+) TCCCAC/TTGGAA 1 -- ut310--------
    rs1431610971,2
    --18804098(+) GGTCTC/GTTCAT 1 -- ut310--------
    rs1507031991,2
    --18804134(+) ATTCAC/GGAAGT 1 -- ut310--------
    rs1399694801,2
    --18804135(+) TTCACA/GAAGTC 1 -- ut310--------
    rs1498322331,2
    C--18804163(+) GACTGC/TGGAAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ARL6IP1 (18802991 - 18813000 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ARL6IP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv428320CNV Loss18775914
    nsv833161CNV Loss17160897
    nsv1752CNV Loss18451855
    nsv469598CNV Gain16826518
    esv34419CNV Gain17911159
    esv587CNV CNV17122850
    dgv823e1CNV Complex17122850
    dgv822e1CNV Complex17122850
    dgv825e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607669   
    OMIM disorders: 615685  
    5 diseases for ARL6IP1:    
    About MalaCards
    microphthalmia    nasopharyngitis    cervical cancer    cervicitis
    cerebritis


    ARL6IP1 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: ARL6IP1 (1 document)

    Export disorders for ARL6IP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARL6IP1 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with ARL6IP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. (PubMed id 24482476)1, 3 Novarino G....Gleeson J.G. (Science 2014)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Characterization, chromosomal localization, and expression during hematopoietic differentiation of the gene encoding Arl6ip, ADP- ribosylation-like factor-6 interacting protein (ARL6). (PubMed id 10995579)1, 2 Pettersson M.... Jonsson J.I. (Genomics 2000)
    4. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2 Nomura N.... Tabata S. (DNA Res. 1994)
    5. ARL6IP1 mediates cisplatin-induced apoptosis in CaSki cervical cancer cells. (PubMed id 20372863)1, 9 Guo F....Li G. (Oncol. Rep. 2010)
    6. Determination of topological structure of ARL6ip1 in cells: identification of the essential binding region of ARL6ip1 for conophylline. (PubMed id 24076029)1 Kuroda M....Simizu S. (FEBS Lett. 2013)
    7. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 23204 HGNC: 697 AceView: RPS15AandARL6IP Ensembl:ENSG00000170540 euGenes: HUgn23204
    ECgene: ARL6IP1 H-InvDB: ARL6IP1

    (According to HUGE)
    About This Section

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    HUGE: KIAA0069

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ARL6IP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ARL6IP1 gene:
    Search GeneIP for patents involving ARL6IP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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