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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARL5C Gene

protein-coding   GIFtS: 36
GCID: GC17M037313

ADP-Ribosylation Factor-Like 5C

(Previous name: ADP-ribosylation factor-like 12)
(Previous symbol: ARL12)
  Search for ARL5C
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ADP-Ribosylation Factor-Like 5C1 2
ARL121 2 3
ADP-Ribosylation Factor-Like 121 2
ADP-Ribosylation Factor-Like Protein 122 3
Putative ADP-Ribosylation Factor-Like Protein 5C2

External Ids:    HGNC: 311111   Entrez Gene: 3907902   Ensembl: ENSG000001417487   UniProtKB: A6NH573   

Export aliases for ARL5C gene to outside databases

Previous GC identifers: GC17M034563 GC17U900719 GC17M033108


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ARL5C Gene: 
ARL5C (ADP-ribosylation factor-like 5C) is a protein-coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is ARL5B.

UniProtKB/Swiss-Prot: ARL5C_HUMAN, A6NH57
Function: Binds and exchanges GTP and GDP (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARL5C gene promoter:
         AML1a   Max   POU2F1   FOXO4   COMP1   SEF-1 (1)   Pax-4a   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ARL5C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL5C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

ARL5C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL5C gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M037313:  view genomic region     (about GC identifiers)

Start:
37,313,147 bp from pter      End:
37,323,737 bp from pter
Size:
10,591 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARL5C_HUMAN, A6NH57 (See protein sequence)
Recommended Name: Putative ADP-ribosylation factor-like protein 5C  
Size: 179 amino acids; 20591 Da

Explore the universe of human proteins at neXtProt for ARL5C: NX_A6NH57

Explore proteomics data for ARL5C at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A6NH57

  • ARL5C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARL5C Protein Expression
    REFSEQ proteins: NP_001137440.1  
    ENSEMBL proteins: 
     ENSP00000269586   ENSP00000466347   ENSP00000387615  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--

    ARL5C for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ARL: ADP-ribosylation factors-like

    4 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF
     IPR005225 Small_GTP-bd_dom

    Graphical View of Domain Structure for InterPro Entry A6NH57

    ProtoNet protein and cluster: A6NH57

    UniProtKB/Swiss-Prot: ARL5C_HUMAN, A6NH57
    Similarity: Belongs to the small GTPase superfamily. Arf family


    ARL5C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARL5C_HUMAN, A6NH57
    Function: Binds and exchanges GTP and GDP (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005525GTP binding IEA--
         
    ARL5C for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ARL5C:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARL5C

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport ----
    GO:0007264small GTPase mediated signal transduction IEA--

    ARL5C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ARL5C

    1 HMDB Compound for ARL5C    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about ARL5C

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARL5C gene: 
    NM_001143968.1  

    Unigene Cluster for ARL5C:

    ADP-ribosylation factor-like 5C
    Hs.568007  [show with all ESTs]
    Unigene Representative Sequence: AK093715
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000269586 ENST00000578912 ENST00000583123 ENST00000581255 ENST00000581554
    ENST00000444555(uc010wea.2)
    miRNA
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Additional mRNA sequence: 

    AK093715.1 AK310706.1 

    2 DOTS entries:

    DT.99929716  DT.100724417 

    24/111 AceView cDNA sequences (see all 111):

    NM_020405 AX748217 BC036059 AW028265 AW027021 BX642578 AI759004 BM695280 
    AF070526 AW630186 BM695263 AF378753 AK093589 AI681339 BQ015491 AA366440 
    AF279144 AL833517 N93789 BM992185 BM998120 BM922940 CD242946 CA489322 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARL5C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGATGGTGG
    ARL5C Expression
    About this image


    See ARL5C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARL5C

    SOURCE GeneReport for Unigene cluster: Hs.568007
        SABiosciences Custom PCR Arrays for ARL5C
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL5C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARL5C gene from 7/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arl5c1 , 5 ADP-ribosylation factor-like 5C1, 5 82.5(n)1
    81.56(a)1
      11 (61.47 cM)5
    2171511  NM_207231.11  NP_997114.11 
     979895785 
    lizard
    (Anolis carolinensis)
    Reptilia ARL5C6
    ADP-ribosylation factor-like 5C
    73(a)
    1 ↔ 1
    6(78621647-78644799)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ619479.12   -- 76.54(n)    BJ619479.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arl5c1 ADP-ribosylation factor-like 5C 68.34(n)
    65.36(a)
      393819  NM_200846.1  NP_957140.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG71976
    --
    58(a)
    1 → many
    3L(8291601-8292939)
    worm
    (Caenorhabditis elegans)
    Secernentea arl-56
    ADP-ribosylation factor-like protein 5
    44(a)
    1 → many
    III(9823235-9824134)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARL16
    Soluble GTPase with a role in regulation of membra...
    39(a)
    1 → many
    II(567875-568426)


    ENSEMBL Gene Tree for ARL5C (if available)
    TreeFam Gene Tree for ARL5C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARL5C gene
    ARL5B2  ARL62  ARL5A2  ARL12  
    18/20 SIMAP similar genes for ARL5C using alignment to 2 protein entries:     ARL5C_HUMAN (see all proteins) (see all similar genes):
    ARL5A    ARL5B    ARF1    ARF6    ARF3    ARF4
    ARF5    ARL14    ARL3    ARL1    ARL2    ARL6
    ARL11    ARL8B    ARL8A    ARFRP1    ARL4A    ARL4C

    ARL5C for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ARL5C
    PGOHUM00000238606


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/284 SNPs in ARL5C are shown (see all 284)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs352120221,2
    C--33115423(+) TTTGC-/T/TT  
            
    TTTTT
    1 -- int11NA 2
    rs356630961,2
    C--37312674(+) TTTCA-/CCGTGT 1 -- ds50011Minor allele frequency- C:0.00NA 2
    rs798173901,2
    C,F--37312699(+) TCCAAC/TTCCTG 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs6824161,2
    C--37312721(+) TCCTCC/TTGCCT 1 -- ds500110Minor allele frequency- T:0.06NA WA CSA 17
    rs359181121,2
    C--37312793(+) CCCCCC/-AACAC 1 -- ds50012Minor allele frequency- -:0.25NA CSA 4
    rs1926866891,2
    C--37312802(+) CCCCAA/GCACAC 1 -- ds50010--------
    rs165191,2
    C,F,H--37312896(+) TCCCTG/AACGTC 1 -- ds500118Minor allele frequency- A:0.05NA NS EA 2032
    rs1464721191,2
    --37312916(+) GATGCC/TTGCGG 1 -- ds50010--------
    rs1165569471,2
    F--37312927(+) CCATGG/AAGTGA 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1843670601,2
    --37312959(+) CTGTCC/TGCAGG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ARL5C (37313147 - 37323737 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ARL5C:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2671727CNV Deletion23128226
    nsv833441CNV Loss17160897
    nsv833440CNV Loss17160897
    dgv3161n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARL5C gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ARL5C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)1, 2 Zody M.C.... Nusbaum C. (2006)
    2. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 390790 HGNC: 31111 AceView: PLXDC1andARL12 Ensembl:ENSG00000141748 euGenes: HUgn390790
    ECgene: ARL5C H-InvDB: ARL5C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARL5C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARL5C gene:
    Search GeneIP for patents involving ARL5C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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