ARL5C Gene
protein-coding GIFtS: 37
GCID: GC17M037313
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|
ADP-ribosylation factor-like 5C(Previous name: ADP-ribosylation factor-like 12 )
(Previous symbol: ARL12)
| |
Aliases
for ARL5C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ADP-Ribosylation Factor-Like 5C1 2 | | ARL121 2 3 | | ADP-Ribosylation Factor-Like 121 2 | | ADP-Ribosylation Factor-Like Protein 122 3 | | Putative ADP-Ribosylation Factor-Like Protein 5C2 |
Export aliases for ARL5C gene to outside databasesPrevious GC identifers: GC17M034563 GC17U900719 GC17M033108 |
Summaries
for ARL5C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ARL5C_HUMAN, A6NH57Function: Binds and exchanges GTP and GDP (By similarity)
|
Genomic Views
for ARL5C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ARL5C gene promoter:
AML1a Max POU2F1 FOXO4 COMP1 SEF-1 (1) Pax-4a c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARL5C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL5C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q12ARL5C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M037313: view genomic region
(about GC identifiers)
Start:
|
37,313,147 bp from pter |
End:
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37,324,102 bp from pter |
Size:
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10,956 bases |
Orientation:
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minus strand |
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Proteins
for ARL5C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ARL5C_HUMAN, A6NH57 (See
protein sequence)Recommended Name: Putative ADP-ribosylation factor-like protein 5C Size: 179 amino acids; 20591 DaExplore the universe of human proteins at neXtProt for ARL5C: NX_A6NH57
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6NH57
ARL5C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001137440.1
ENSEMBL proteins: ENSP00000269586 ENSP00000466347 ENSP00000387615
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
ARL5C for ontologies About GeneDecksing
ARL5C Antibody Products:
Assay Products for ARL5C: |
Protein
Domains /
Families
for ARL5C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARL5C for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A6NH57ProtoNet protein and cluster: A6NH57 UniProtKB/Swiss-Prot: ARL5C_HUMAN, A6NH57Similarity: Belongs to the small GTPase superfamily. Arf family |
Function
for ARL5C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ARL5C_HUMAN, A6NH57Function: Binds and exchanges GTP and GDP (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARL5C (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARL5C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for ARL5C | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARL5C |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL5C |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005525 | GTP binding |
IEA | -- |
ARL5C for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for ARL5C:
|
Pathways & Interactions
for ARL5C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARL5C
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
IEA | -- |
ARL5C for ontologies About GeneDecksing
|
Drugs & Compounds
for ARL5C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ARL5C
1 HMDB Compound for ARL5C About this table
Search CenterWatch for drugs/clinical trials and news about ARL5C
|
Transcripts
for ARL5C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ARL5C gene: NM_001143968.1 Unigene Cluster for ARL5C: ADP-ribosylation factor-like 5C Hs.568007 [show with all ESTs]Unigene Representative Sequence: AK0937156 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000269586 ENST00000578912 ENST00000583123 ENST00000581255 ENST00000581554
ENST00000444555(uc010wea.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARL5C (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARL5C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ARL5C (NM_001143968) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARL5C | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARL5C |
Additional cDNA sequence: AK093715.1 AK310706.1 2 DOTS entries: DT.99929716 DT.100724417 24/111 AceView cDNA sequences (see all 111): AW630186 AI759004 BC036059 AW028265 AF378753 AW027021 NM_020405 AI681339 BM695280 AA366440 BX642578 AF070526 AF279144 AK093589 AX748217 BM695263 BQ015491 BM998120 N93789 BM992185 CA489322 F17685 AI567729 BV178998
GeneLoc Exon Structure
|
Expression
for ARL5C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARL5C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGATGGTGG
About this image
See ARL5C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARL5C
SOURCE GeneReport for Unigene cluster: Hs.568007
SABiosciences Custom PCR Arrays for ARL5C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARL5C
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARL5C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARL5C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARL5C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL5C |
Orthologs
for ARL5C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ARL5C gene from 7/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
ARL5C6 |
-- |
65(a) |
1 ↔ 1 |
6(78630714-78643644) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BJ619479.12 |
-- |
76.54(n) |
|
BJ619479.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
arl5c1 |
ADP-ribosylation factor-like 5C |
68.34(n)
65.36(a) |
|
393819 NM_200846.1 NP_957140.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG71976 |
-- |
58(a) |
1 → many |
3L(8291601-8292939) |
worm
(Caenorhabditis elegans) |
Secernentea |
arl-56 |
ADP-ribosylation factor-like protein 5 |
44(a) |
1 → many |
III(9823148-9824047) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ARFC16 |
ADP-ribosylation factor C1 |
44(a) |
1 → many |
3(8136181-8138084) |
rice
(Oryza sativa) |
Liliopsida |
-- |
ADP-ribosylation factor, putative, expressed |
45(a) |
1 → many |
11(21749662-21752992) |
ENSEMBL Gene Tree for ARL5C (if available)
TreeFam Gene Tree for ARL5C (if available) |
Paralogs
for ARL5C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ARL5C gene
- ARL5B2 ARL162 ARL62 ARL5A2 ARL12
18/20 SIMAP similar genes for ARL5C using alignment to 2 protein entries: ARL5C_HUMAN (see all proteins)
(see all similar genes):ARL5A ARL5B ARF1 ARF6 ARF3 ARF4
ARF5 ARL14 ARL3 ARL1 ARL6 ARL11
ARL8B ARL2 ARL8A ARFRP1 ARL4A ARL4C
ARL5C for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ARL5C
PGOHUM00000238606
|
Genomic Variants
for ARL5C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ARL5C (37313147 - 37324102 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ARL5C
1 CNV: 5006 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARL5C |
|
Disorders
/ Diseases
for ARL5C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ARL5C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARL5C gene integrated from 9 sources:
(articles sorted by number of sources associating them with ARL5C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)1, 2 Zody M.C.... Nusbaum C. (2006)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
|
External Searches for ARL5C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ARL5C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ARL5C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ARL5C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ARL5C | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ARL5C gene:
Search GeneIP for patents involving ARL5C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ARL5C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ARL5C | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARL5C | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARL5C | | | OriGene Protein Over-expression Lysate for ARL5C | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ARL5C | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARL5C | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARL5C | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | | Search Tocris compounds for ARL5C |
| |  |  |  |  | | | | |
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 | | | ARL5C Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL5C |
|  |  |  | | | | Search ThermoFisher Antibodies for ARL5C |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARL5C |
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