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Aliases for ARL5C Gene

Aliases for ARL5C Gene

  • ADP Ribosylation Factor Like GTPase 5C 2 3 5
  • ADP-Ribosylation Factor-Like Protein 12 3 4
  • ADP-Ribosylation Factor-Like 12 2 3
  • ADP-Ribosylation Factor-Like 5C 2 3
  • ARL12 3 4
  • Putative ADP-Ribosylation Factor-Like Protein 5C 3

External Ids for ARL5C Gene

Previous HGNC Symbols for ARL5C Gene

  • ARL12

Previous GeneCards Identifiers for ARL5C Gene

  • GC17M034563
  • GC17U900719
  • GC17M037313
  • GC17M033108

Summaries for ARL5C Gene

GeneCards Summary for ARL5C Gene

ARL5C (ADP Ribosylation Factor Like GTPase 5C) is a Protein Coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is ARL5B.

UniProtKB/Swiss-Prot for ARL5C Gene

  • Binds and exchanges GTP and GDP.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL5C Gene

Genomics for ARL5C Gene

Regulatory Elements for ARL5C Gene

Enhancers for ARL5C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F039056 0.9 ENCODE 11.2 +110.5 110454 1.3 PKNOX1 ARID4B FEZF1 ZNF48 ZNF2 ZNF207 KLF7 KLF13 ZNF263 SP3 PLXDC1 LOC100131347 ARL5C LINC00672 PIR45010
GH17F039013 1.1 Ensembl ENCODE 10.5 +150.8 150808 5.4 PKNOX1 ATF1 ELK1 GATA2 FOS KLF13 TSHZ1 ZNF518A CREB3 MEF2D FBXO47 ARL5C CACNB1 RPL19 CWC25 ENSG00000266588 GC17M039013 ENSG00000277426
GH17F039164 0.7 ENCODE 10.2 +2.3 2306 1.5 HDGF PKNOX1 ZNF76 SIN3A ZNF2 RAD21 ZNF121 GLIS2 ZNF366 ZNF143 ARL5C ENSG00000280177
GH17F039165 0.2 ENCODE 10.1 +0.4 392 2.3 ZMYM3 MAX ZNF16 TBX21 ZNF121 GATA3 POLR2A SMARCA4 IKZF1 PRDM10 ARL5C MRPL45 ENSG00000280177
GH17F039174 1.3 Ensembl ENCODE 5.6 -7.4 -7410 1.6 CTCF ZFP64 KLF17 ZNF140 ZNF266 ZNF48 RAD21 ZNF101 HIC1 ZBTB48 ENSG00000275665 CDK12 ENSG00000266469 MED1 ENSG00000275532 RPL19 SNORA21 CACNB1 LOC100287808 RPL23
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ARL5C on UCSC Golden Path with GeneCards custom track

Genomic Location for ARL5C Gene

39,156,894 bp from pter
39,167,484 bp from pter
10,591 bases
Minus strand

Genomic View for ARL5C Gene

Genes around ARL5C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL5C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL5C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL5C Gene

Proteins for ARL5C Gene

  • Protein details for ARL5C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative ADP-ribosylation factor-like protein 5C
    Protein Accession:

    Protein attributes for ARL5C Gene

    179 amino acids
    Molecular mass:
    20591 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARL5C Gene

Post-translational modifications for ARL5C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARL5C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARL5C Gene

Domains & Families for ARL5C Gene

Gene Families for ARL5C Gene

Protein Domains for ARL5C Gene

Suggested Antigen Peptide Sequences for ARL5C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Arf family.
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL5C: view

Function for ARL5C Gene

Molecular function for ARL5C Gene

UniProtKB/Swiss-Prot Function:
Binds and exchanges GTP and GDP.

Gene Ontology (GO) - Molecular Function for ARL5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with ARL5C: view
genes like me logo Genes that share phenotypes with ARL5C: view

Animal Models for ARL5C Gene

MGI Knock Outs for ARL5C:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARL5C Gene

Localization for ARL5C Gene

Subcellular locations from

Jensen Localization Image for ARL5C Gene COMPARTMENTS Subcellular localization image for ARL5C gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ARL5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with ARL5C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARL5C Gene

Pathways & Interactions for ARL5C Gene

SuperPathways for ARL5C Gene

No Data Available

Interacting Proteins for ARL5C Gene

Gene Ontology (GO) - Biological Process for ARL5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with ARL5C: view

No data available for Pathways by source and SIGNOR curated interactions for ARL5C Gene

Drugs & Compounds for ARL5C Gene

(1) Drugs for ARL5C Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARL5C: view

Transcripts for ARL5C Gene

Unigene Clusters for ARL5C Gene

ADP-ribosylation factor-like 5C:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL5C Gene

No ASD Table

Relevant External Links for ARL5C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARL5C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARL5C Gene

mRNA differential expression in normal tissues according to GTEx for ARL5C Gene

This gene is overexpressed in Pancreas (x7.2) and Brain - Putamen (basal ganglia) (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of ARL5C Gene:


SOURCE GeneReport for Unigene cluster for ARL5C Gene:

genes like me logo Genes that share expression patterns with ARL5C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ARL5C Gene

Orthologs for ARL5C Gene

This gene was present in the common ancestor of animals.

Orthologs for ARL5C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARL5C 34 35
  • 99.44 (n)
(Canis familiaris)
Mammalia ARL5C 34 35
  • 86.59 (n)
(Bos Taurus)
Mammalia LOC787781 34
  • 85.47 (n)
ARL5C 35
  • 78 (a)
(Mus musculus)
Mammalia Arl5c 34 16 35
  • 82.5 (n)
(Rattus norvegicus)
Mammalia Arl5c 34
  • 81.19 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 36 (a)
(Anolis carolinensis)
Reptilia ARL5C 35
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arl5b 34
  • 70.58 (n)
(Danio rerio)
Actinopterygii arl5c 34 35
  • 68.34 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7197 35
  • 58 (a)
(Caenorhabditis elegans)
Secernentea arl-5 34 35
  • 52.71 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10998 35
  • 31 (a)
Species where no ortholog for ARL5C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARL5C Gene

Gene Tree for ARL5C (if available)
Gene Tree for ARL5C (if available)

Paralogs for ARL5C Gene

Paralogs for ARL5C Gene

(20) SIMAP similar genes for ARL5C Gene using alignment to 2 proteins: Pseudogenes for ARL5C Gene

genes like me logo Genes that share paralogs with ARL5C: view

Variants for ARL5C Gene

Sequence variations from dbSNP and Humsavar for ARL5C Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs111367073 -- 39,160,774(+) TCAGC(C/G)TGCTA intron-variant
rs111588569 -- 39,159,304(+) TTTTT(C/T)TTTTT intron-variant
rs111699605 -- 39,159,695(+) TTGCT(C/T)GCTGC intron-variant
rs111803680 -- 39,163,504(+) TCTCC(C/T)GCCTC intron-variant, upstream-variant-2KB
rs111805003 -- 39,159,385(+) TCCGC(C/T)TCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARL5C Gene

Variant ID Type Subtype PubMed ID
esv2671727 CNV deletion 23128226
esv3640539 CNV loss 21293372
esv3893011 CNV loss 25118596
nsv1146669 OTHER inversion 26484159
nsv833440 CNV loss 17160897
nsv833441 CNV loss 17160897

Variation tolerance for ARL5C Gene

Gene Damage Index Score: 13.81; 95.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARL5C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL5C Gene

Disorders for ARL5C Gene

Relevant External Links for ARL5C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARL5C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL5C Gene

Publications for ARL5C Gene

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 3 4 64
  2. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3 64

Products for ARL5C Gene

Sources for ARL5C Gene

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