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ARL5C Gene

protein-coding   GIFtS: 38
GCID: GC17M037313

ADP-Ribosylation Factor-Like 5C

(Previous name: ADP-ribosylation factor-like 12)
(Previous symbol: ARL12)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADP-Ribosylation Factor-Like 5C1 2
ARL121 2 3
ADP-Ribosylation Factor-Like 121 2
ADP-Ribosylation Factor-Like Protein 122 3
Putative ADP-Ribosylation Factor-Like Protein 5C2

External Ids:    HGNC: 311111   Entrez Gene: 3907902   Ensembl: ENSG000001417487   UniProtKB: A6NH573   

Export aliases for ARL5C gene to outside databases

Previous GC identifers: GC17M034563 GC17U900719 GC17M033108


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ARL5C Gene:
ARL5C (ADP-ribosylation factor-like 5C) is a protein-coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is ARL2.

UniProtKB/Swiss-Prot: ARL5C_HUMAN, A6NH57
Function: Binds and exchanges GTP and GDP (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARL5C gene promoter:
         AML1a   Max   POU2F1   FOXO4   COMP1   SEF-1 (1)   Pax-4a   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ARL5C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARL5C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

ARL5C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL5C gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M037313:  view genomic region     (about GC identifiers)

Start:
37,313,147 bp from pter      End:
37,323,737 bp from pter
Size:
10,591 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARL5C_HUMAN, A6NH57 (See protein sequence)
Recommended Name: Putative ADP-ribosylation factor-like protein 5C  
Size: 179 amino acids; 20591 Da

Explore the universe of human proteins at neXtProt for ARL5C: NX_A6NH57

Explore proteomics data for ARL5C at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARL5C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001137440.1  
    ENSEMBL proteins: 
     ENSP00000269586   ENSP00000466347   ENSP00000387615  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARL: ADP-ribosylation factors-like
    ARF: ADP-ribosylation factors

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR027417 P-loop_NTPase
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF

    Graphical View of Domain Structure for InterPro Entry A6NH57

    ProtoNet protein and cluster: A6NH57

    UniProtKB/Swiss-Prot: ARL5C_HUMAN, A6NH57
    Similarity: Belongs to the small GTPase superfamily. Arf family


    Find genes that share domains with ARL5C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARL5C_HUMAN, A6NH57
    Function: Binds and exchanges GTP and GDP (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with ARL5C           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for ARL5C:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         1 MGI phenotypic allele for Arl5c (no phenotypes)

    Find genes that share phenotypes with ARL5C           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARL5C
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--

    Find genes that share ontologies with ARL5C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARL5C
    Interactions:

        Search GeneGlobe Interaction Network for ARL5C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for ARL5C (ENSP000002695864) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIGTENSP000002790364STRING: ENSP00000279036
    POLR3EENSP000002998534STRING: ENSP00000299853
    STX16ENSP000003601834STRING: ENSP00000360183
    GBF1ENSP000003590004STRING: ENSP00000359000
    CLTCENSP000002691224STRING: ENSP00000269122
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport ----
    GO:0007264small GTPase mediated signal transduction IEA--

    Find genes that share ontologies with ARL5C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARL5C

    1 HMDB Compound for ARL5C    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARL5C gene: 
    NM_001143968.1  

    Unigene Cluster for ARL5C:

    ADP-ribosylation factor-like 5C
    Hs.568007  [show with all ESTs]
    Unigene Representative Sequence: AK093715
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000269586 ENST00000578912 ENST00000583123 ENST00000581255 ENST00000581554
    ENST00000444555(uc010wea.2)
    miRNA
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    Additional mRNA sequence: 

    AK093715.1 AK310706.1 

    2 DOTS entries:

    DT.99929716  DT.100724417 

    Selected AceView cDNA sequences (see all 111):

    AF378753 BC036059 AW630186 AW027021 NM_020405 BM695280 BX642578 AW028265 
    AF279144 AI759004 AI681339 AK093589 BQ015491 BM695263 AX748217 AA366440 
    AF070526 CN480269 AA922709 BQ007112 CD242946 AI567729 AI806061 AA781163 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARL5C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGATGGTGG
    ARL5C Expression
    About this image

    ARL5C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARL5C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.568007
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARL5C gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arl5c1 , 5 ADP-ribosylation factor-like 5C1, 5 82.5(n)1
    81.56(a)1
      11 (61.47 cM)5
    2171511  NM_207231.11  NP_997114.11 
     979895785 
    lizard
    (Anolis carolinensis)
    Reptilia ARL5C6
    ADP-ribosylation factor-like 5C
    73(a)
    1 ↔ 1
    6(78621647-78644799)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ619479.12   -- 76.54(n)    BJ619479.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arl5c1 ADP-ribosylation factor-like 5C 68.34(n)
    65.36(a)
      393819  NM_200846.1  NP_957140.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG71976
    --
    58(a)
    1 → many
    3L(8291601-8292939)
    worm
    (Caenorhabditis elegans)
    Secernentea arl-51 arl-5 52.71(n)
    46.51(a)
      176392  NM_066777.3  NP_499178.1 


    ENSEMBL Gene Tree for ARL5C (if available)
    TreeFam Gene Tree for ARL5C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARL5C gene
    ARL22  ARL5B2  ENSG000002730032  ARF42  ENSG000002728222  ARF52  ARF12  ARL32  
    ARL5A2  ARF32  ARF62  TRIM232  
    Selected SIMAP similar genes for ARL5C using alignment to 2 protein entries:     ARL5C_HUMAN (see all proteins) (see all similar genes):
    ARL5A    ARL5B    ARF1    ARF6    ARF3    ARF4
    ARF5    ARL14    ARL3    ARL1    ARL2    ARL6
    ARL11    ARL8B    ARFRP1    ARL8A    ARL4A    ARL4C

    Find genes that share paralogs with ARL5C           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ARL5C
    PGOHUM00000238606


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARL5C (see all 284)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs352120221,2
    C--33115423(+) TTTGC-/T/TT  
            
    TTTTT
    1 -- int11NA 2
    rs356630961,2
    C--37312674(+) TTTCA-/CCGTGT 1 -- ds50011Minor allele frequency- C:0.00NA 2
    rs798173901,2
    C,F--37312699(+) TCCAAC/TTCCTG 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs6824161,2
    C--37312721(+) TCCTCC/TTGCCT 1 -- ds500110Minor allele frequency- T:0.06NA WA CSA 17
    rs359181121,2
    C--37312793(+) CCCCCC/-AACAC 1 -- ds50012Minor allele frequency- -:0.25NA CSA 4
    rs1926866891,2
    C--37312802(+) CCCCAA/GCACAC 1 -- ds50010--------
    rs165191,2
    C,F,H--37312896(+) TCCCTG/AACGTC 1 -- ds500118Minor allele frequency- A:0.05NA NS EA 2032
    rs1464721191,2
    --37312916(+) GATGCC/TTGCGG 1 -- ds50010--------
    rs1165569471,2
    F--37312927(+) CCATGG/AAGTGA 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1843670601,2
    --37312959(+) CTGTCC/TGCAGG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ARL5C (37313147 - 37323737 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ARL5C:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671727CNV Deletion23128226
    nsv833441CNV Loss17160897
    nsv833440CNV Loss17160897
    dgv3161n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARL5C gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ARL5C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)1, 2 Zody M.C.... Nusbaum C. (Nature 2006)
    2. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 390790 HGNC: 31111 AceView: PLXDC1andARL12 Ensembl:ENSG00000141748 euGenes: HUgn390790
    ECgene: ARL5C H-InvDB: ARL5C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARL5C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARL5C gene:
    Search GeneIP for patents involving ARL5C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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