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Aliases for ARL5C Gene

Aliases for ARL5C Gene

  • ADP Ribosylation Factor Like GTPase 5C 2 3 5
  • ADP-Ribosylation Factor-Like Protein 12 3 4
  • ADP-Ribosylation Factor-Like 12 2 3
  • ADP-Ribosylation Factor-Like 5C 2 3
  • ARL12 3 4
  • ADP-Ribosylation Factor Like GTPase 5C 3

External Ids for ARL5C Gene

Previous HGNC Symbols for ARL5C Gene

  • ARL12

Previous GeneCards Identifiers for ARL5C Gene

  • GC17M034563
  • GC17U900719
  • GC17M037313
  • GC17M033108

Summaries for ARL5C Gene

GeneCards Summary for ARL5C Gene

ARL5C (ADP Ribosylation Factor Like GTPase 5C) is a Protein Coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is ENSG00000272822.

UniProtKB/Swiss-Prot for ARL5C Gene

  • Binds and exchanges GTP and GDP.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL5C Gene

Genomics for ARL5C Gene

Regulatory Elements for ARL5C Gene

Enhancers for ARL5C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARL5C on UCSC Golden Path with GeneCards custom track

Genomic Location for ARL5C Gene

39,156,894 bp from pter
39,167,484 bp from pter
10,591 bases
Minus strand

Genomic View for ARL5C Gene

Genes around ARL5C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL5C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL5C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL5C Gene

Proteins for ARL5C Gene

  • Protein details for ARL5C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative ADP-ribosylation factor-like protein 5C
    Protein Accession:

    Protein attributes for ARL5C Gene

    179 amino acids
    Molecular mass:
    20591 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARL5C Gene

Proteomics data for ARL5C Gene at MOPED

Post-translational modifications for ARL5C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARL5C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARL5C Gene

Domains & Families for ARL5C Gene

Gene Families for ARL5C Gene

Protein Domains for ARL5C Gene

Suggested Antigen Peptide Sequences for ARL5C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Arf family.
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL5C: view

Function for ARL5C Gene

Molecular function for ARL5C Gene

UniProtKB/Swiss-Prot Function:
Binds and exchanges GTP and GDP.

Phenotypes for ARL5C Gene

genes like me logo Genes that share phenotypes with ARL5C: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL5C Gene

Localization for ARL5C Gene

Subcellular locations from

Jensen Localization Image for ARL5C Gene COMPARTMENTS Subcellular localization image for ARL5C gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ARL5C Gene

Pathways & Interactions for ARL5C Gene

SuperPathways for ARL5C Gene

No Data Available

Interacting Proteins for ARL5C Gene

Gene Ontology (GO) - Biological Process for ARL5C Gene


No data available for Pathways by source and SIGNOR curated interactions for ARL5C Gene

Drugs & Compounds for ARL5C Gene

(1) Drugs for ARL5C Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARL5C: view

Transcripts for ARL5C Gene

Unigene Clusters for ARL5C Gene

ADP-ribosylation factor-like 5C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARL5C Gene

No ASD Table

Relevant External Links for ARL5C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARL5C Gene

mRNA expression in normal human tissues for ARL5C Gene

mRNA differential expression in normal tissues according to GTEx for ARL5C Gene

This gene is overexpressed in Pancreas (x7.2) and Brain - Putamen (basal ganglia) (x4.5).

SOURCE GeneReport for Unigene cluster for ARL5C Gene Hs.568007

genes like me logo Genes that share expression patterns with ARL5C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ARL5C Gene

Orthologs for ARL5C Gene

This gene was present in the common ancestor of animals.

Orthologs for ARL5C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC787781 35
  • 85.47 (n)
  • 79.21 (a)
ARL5C 36
  • 78 (a)
(Canis familiaris)
Mammalia ARL5C 35
  • 86.59 (n)
  • 82.68 (a)
ARL5C 36
  • 83 (a)
(Mus musculus)
Mammalia Arl5c 35
  • 82.5 (n)
  • 81.56 (a)
Arl5c 16
Arl5c 36
  • 82 (a)
(Pan troglodytes)
Mammalia ARL5C 35
  • 99.44 (n)
  • 98.88 (a)
ARL5C 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Arl5c 35
  • 81.19 (n)
  • 78.77 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 36 (a)
(Anolis carolinensis)
Reptilia ARL5C 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arl5b 35
  • 70.58 (n)
  • 71.51 (a)
(Danio rerio)
Actinopterygii arl5c 35
  • 68.34 (n)
  • 65.36 (a)
arl5c 36
  • 65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7197 36
  • 58 (a)
(Caenorhabditis elegans)
Secernentea arl-5 35
  • 52.71 (n)
  • 46.51 (a)
arl-5 36
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10998 36
  • 31 (a)
Species with no ortholog for ARL5C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARL5C Gene

Gene Tree for ARL5C (if available)
Gene Tree for ARL5C (if available)

Paralogs for ARL5C Gene

(20) SIMAP similar genes for ARL5C Gene using alignment to 2 proteins: Pseudogenes for ARL5C Gene

genes like me logo Genes that share paralogs with ARL5C: view

Variants for ARL5C Gene

Sequence variations from dbSNP and Humsavar for ARL5C Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs16519 -- 39,156,643(+) TCCCT(A/G)ACGTC downstream-variant-500B
rs16520 -- 39,156,736(+) AGCTT(C/G)TCAGC downstream-variant-500B
rs16521 -- 39,160,565(+) CCCTA(A/G)AGATC intron-variant
rs16522 -- 39,160,735(+) CATCC(C/T)GTAGA reference, missense
rs16523 -- 39,160,903(+) CAACC(A/G)TATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARL5C Gene

Variant ID Type Subtype PubMed ID
nsv833440 CNV Loss 17160897
dgv3161n71 CNV Loss 21882294
esv2671727 CNV Deletion 23128226
nsv833441 CNV Loss 17160897

Variation tolerance for ARL5C Gene

Gene Damage Index Score: 13.81; 95.84% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ARL5C Gene

Disorders for ARL5C Gene

Relevant External Links for ARL5C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARL5C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL5C Gene

Publications for ARL5C Gene

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 3 4 67
  2. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3

Products for ARL5C Gene

Sources for ARL5C Gene