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Aliases for ARL5B Gene

Aliases for ARL5B Gene

  • ADP Ribosylation Factor Like GTPase 5B 2 3 5
  • ADP-Ribosylation Factor-Like Protein 8 3 4
  • ADP-Ribosylation Factor-Like 5B 2 3
  • ADP-Ribosylation Factor-Like 8 2 3
  • ARL8 3 4
  • ADP-Ribosylation Factor Like GTPase 5B 3
  • ADP-Ribosylation-Like Factor 8 3

External Ids for ARL5B Gene

Previous HGNC Symbols for ARL5B Gene

  • ARL8

Previous GeneCards Identifiers for ARL5B Gene

  • GC10P018989
  • GC10P018948

Summaries for ARL5B Gene

Entrez Gene Summary for ARL5B Gene

  • ARL5B (ARL8) belongs to a family of proteins that are structurally similar to ADP-ribosylation factors (ARFs; see MIM 103180). ARLs and ARFs are part of the RAS superfamily of regulatory GTPases.[supplied by OMIM, Nov 2010]

GeneCards Summary for ARL5B Gene

ARL5B (ADP Ribosylation Factor Like GTPase 5B) is a Protein Coding gene. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is ENSG00000272822.

UniProtKB/Swiss-Prot for ARL5B Gene

  • Binds and exchanges GTP and GDP.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL5B Gene

Genomics for ARL5B Gene

Regulatory Elements for ARL5B Gene

Enhancers for ARL5B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARL5B on UCSC Golden Path with GeneCards custom track

Promoters for ARL5B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARL5B on UCSC Golden Path with GeneCards custom track

Genomic Location for ARL5B Gene

18,659,335 bp from pter
18,681,639 bp from pter
22,305 bases
Plus strand

Genomic View for ARL5B Gene

Genes around ARL5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL5B Gene

Proteins for ARL5B Gene

  • Protein details for ARL5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP-ribosylation factor-like protein 5B
    Protein Accession:

    Protein attributes for ARL5B Gene

    179 amino acids
    Molecular mass:
    20375 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ARL5B Gene

neXtProt entry for ARL5B Gene

Proteomics data for ARL5B Gene at MOPED

Post-translational modifications for ARL5B Gene

  • Ubiquitination at Lys 103
  • Modification sites at PhosphoSitePlus

Other Protein References for ARL5B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARL5B Gene

Domains & Families for ARL5B Gene

Gene Families for ARL5B Gene

Protein Domains for ARL5B Gene

Suggested Antigen Peptide Sequences for ARL5B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Arf family.
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL5B: view

Function for ARL5B Gene

Molecular function for ARL5B Gene

UniProtKB/Swiss-Prot Function:
Binds and exchanges GTP and GDP.
genes like me logo Genes that share phenotypes with ARL5B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ARL5B

CRISPR Products

miRNA for ARL5B Gene

miRTarBase miRNAs that target ARL5B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL5B Gene

Localization for ARL5B Gene

Subcellular locations from

Jensen Localization Image for ARL5B Gene COMPARTMENTS Subcellular localization image for ARL5B gene
Compartment Confidence
cytosol 2
extracellular 2
cytoskeleton 1
endosome 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ARL5B Gene

Pathways & Interactions for ARL5B Gene

SuperPathways for ARL5B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL5B Gene


No data available for Pathways by source and SIGNOR curated interactions for ARL5B Gene

Drugs & Compounds for ARL5B Gene

(2) Drugs for ARL5B Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma Target 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARL5B: view

Transcripts for ARL5B Gene

mRNA/cDNA for ARL5B Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(127) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARL5B Gene

ADP-ribosylation factor-like 5B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARL5B Gene

No ASD Table

Relevant External Links for ARL5B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARL5B Gene

mRNA expression in normal human tissues for ARL5B Gene

mRNA differential expression in normal tissues according to GTEx for ARL5B Gene

This gene is overexpressed in Liver (x4.3).

Protein differential expression in normal tissues from HIPED for ARL5B Gene

This gene is overexpressed in Bone (40.0) and Plasma (22.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARL5B Gene

SOURCE GeneReport for Unigene cluster for ARL5B Gene Hs.25362

genes like me logo Genes that share expression patterns with ARL5B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ARL5B Gene

Orthologs for ARL5B Gene

This gene was present in the common ancestor of animals.

Orthologs for ARL5B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARL5B 35
  • 96.46 (n)
  • 100 (a)
ARL5B 36
  • 100 (a)
(Canis familiaris)
Mammalia ARL5B 35
  • 95.53 (n)
  • 100 (a)
ARL5B 36
  • 99 (a)
(Mus musculus)
Mammalia Arl5b 35
  • 92.36 (n)
  • 100 (a)
Arl5b 16
Arl5b 36
  • 99 (a)
(Pan troglodytes)
Mammalia ARL5B 35
  • 100 (n)
  • 100 (a)
ARL5B 36
  • 100 (a)
(Monodelphis domestica)
Mammalia ARL5B 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia ARL5B 36
  • 96 (a)
(Gallus gallus)
Aves ARL5B 35
  • 85.29 (n)
  • 98.32 (a)
ARL5B 36
  • 98 (a)
(Anolis carolinensis)
Reptilia ARL5B 36
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arl5a 35
  • 82.31 (n)
  • 94.41 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5203 35
(Danio rerio)
Actinopterygii arl8 35
  • 81.01 (n)
  • 94.97 (a)
wufi17a05 35
arl8 36
  • 96 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7197 36
  • 71 (a)
(Caenorhabditis elegans)
Secernentea arl-5 36
  • 52 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11870 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
Species with no ortholog for ARL5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARL5B Gene

Gene Tree for ARL5B (if available)
Gene Tree for ARL5B (if available)

Paralogs for ARL5B Gene Pseudogenes for ARL5B Gene

genes like me logo Genes that share paralogs with ARL5B: view

Variants for ARL5B Gene

Sequence variations from dbSNP and Humsavar for ARL5B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1626860 -- 18,664,548(+) ttctt(C/G)tgctt intron-variant
rs1687067 -- 18,673,877(-) CACTA(G/T)TATTT intron-variant
rs1687068 -- 18,673,225(-) AATTA(A/C)CCAGG intron-variant
rs1687071 -- 18,682,104(+) CCTGG(A/G)AAGGT downstream-variant-500B
rs1687084 -- 18,673,961(-) TATTT(A/C)TAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARL5B Gene

Variant ID Type Subtype PubMed ID
nsv466762 CNV Gain 19166990

Variation tolerance for ARL5B Gene

Residual Variation Intolerance Score: 40.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARL5B Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL5B Gene

Disorders for ARL5B Gene

Relevant External Links for ARL5B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARL5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL5B Gene

Publications for ARL5B Gene

  1. Isolation of a new member of the ADP-ribosylation like factor gene family, ARL8, from a cartilage cDNA library. (PMID: 12853149) Sebald E. … Krakow D. (Gene 2003) 2 3 4 67
  2. Arl5b is a Golgi-localised small G protein involved in the regulation of retrograde transport. (PMID: 22245584) Houghton F.J. … Gleeson P.A. (Exp. Cell Res. 2012) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation. (PMID: 25496667) Landi A. … Verhasselt B. (Retrovirology 2014) 3
  5. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat B.E. … Tseng Z.H. (BMC Cardiovasc Disord 2011) 3

Products for ARL5B Gene

Sources for ARL5B Gene