Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARL5B Gene

protein-coding   GIFtS: 55
GCID: GC10P018948

ADP-Ribosylation Factor-Like 5B

(Previous name: ADP-ribosylation factor-like 8)
(Previous symbol: ARL8)
Alzheimer's & Parkinson's Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ADP-Ribosylation Factor-Like 5B1 2
ARL81 2 3
ADP-Ribosylation Factor-Like 81 2
ADP-Ribosylation Factor-Like Protein 82 3
ADP-Ribosylation Factor-Like Protein 5B2
ADP-Ribosylation-Like Factor 82

External Ids:    HGNC: 230521   Entrez Gene: 2210792   Ensembl: ENSG000001659977   OMIM: 6089095   UniProtKB: Q96KC23   

Export aliases for ARL5B gene to outside databases

Previous GC identifers: GC10P018989 GC10P018608


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARL5B Gene:
ARL5B (ARL8) belongs to a family of proteins that are structurally similar to ADP-ribosylation factors (ARFs; see
MIM 103180). ARLs and ARFs are part of the RAS superfamily of regulatory GTPases.(supplied by OMIM, Nov 2010)

GeneCards Summary for ARL5B Gene: 
ARL5B (ADP-ribosylation factor-like 5B) is a protein-coding gene. Diseases associated with ARL5B include alzheimer's disease. GO annotations related to this gene include GTP binding. An important paralog of this gene is ARL5C.

UniProtKB/Swiss-Prot: ARL5B_HUMAN, Q96KC2
Function: Binds and exchanges GTP and GDP




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_008705.16  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARL5B gene promoter:
         Oct-B1   oct-B3   oct-B2   AML1a   p53   CREB   POU2F1   deltaCREB   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARL5B promoter sequence
   Search SABiosciences Chromatin IP Primers for ARL5B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.31   Ensembl cytogenetic band:  10p12.31   HGNC cytogenetic band: 10p13

ARL5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL5B gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P018948:  view genomic region     (about GC identifiers)

Start:
18,948,313 bp from pter      End:
18,970,568 bp from pter
Size:
22,256 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARL5B_HUMAN, Q96KC2 (See protein sequence)
Recommended Name: ADP-ribosylation factor-like protein 5B  
Size: 179 amino acids; 20375 Da
1 PDB 3D structure from and Proteopedia for ARL5B:
1YZG (3D)    

Explore the universe of human proteins at neXtProt for ARL5B: NX_Q96KC2

Explore proteomics data for ARL5B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96KC2

  • ARL5B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARL5B Protein Expression
    REFSEQ proteins: NP_848930.1  
    ENSEMBL proteins: 
     ENSP00000366487  

    Human Recombinant Protein Products for ARL5B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ARL5B
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ARL5B
    GenScript Custom Purified and Recombinant Proteins Services for ARL5B
    Novus Biologicals ARL5B Proteins
    Novus Biologicals ARL5B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for ARL5B
    Cloud-Clone Corp. Proteins for ARL5B 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----

    ARL5B for ontologies           About GeneDecksing



    ARL5B Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ARL5B
    OriGene Custom Antibody Services for ARL5B
    GenScript Custom Superior Antibodies Services for ARL5B
    Novus Biologicals ARL5B Antibodies
    Abcam antibodies for ARL5B
    Cloud-Clone Corp. Antibodies for ARL5B 
    ThermoFisher Antibodies for ARL5B
    LSBio Antibodies in human, mouse, rat for ARL5B 

    Assay Products for ARL5B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ARL5B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ARL5B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ARL5B 
    Cloud-Clone Corp. CLIAs for ARL5B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ARL: ADP-ribosylation factors-like

    4 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF
     IPR005225 Small_GTP-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q96KC2

    ProtoNet protein and cluster: Q96KC2

    1 Blocks protein domain: IPB006688 ADP-ribosylation factor

    UniProtKB/Swiss-Prot: ARL5B_HUMAN, Q96KC2
    Similarity: Belongs to the small GTPase superfamily. Arf family


    ARL5B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARL5B_HUMAN, Q96KC2
    Function: Binds and exchanges GTP and GDP

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0004871signal transducer activity ----
    GO:0005525GTP binding IEA--
    GO:0019001guanyl nucleotide binding ----
    GO:0031683G-protein beta/gamma-subunit complex binding ----
         
    ARL5B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ARL5B:
     Decreased viability of wild-ty 

         1 MGI phenotypic allele for Arl5b (no phenotypes)

    ARL5B for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ARL5B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ARL5B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARL5B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARL5B 

    miRNA
    Products:
        
    miRTarBase miRNAs that target ARL5B:
    hsa-mir-155 (MIRT001567)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARL5B
    8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate ARL5B (see all 54):
    hsa-miR-4291 hsa-miR-607 hsa-miR-4328 hsa-miR-188-5p hsa-miR-15a hsa-miR-503 hsa-miR-624 hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidARL5B 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ARL5B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARL5B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ARL5B
    Sirion Biotech Customized adenovirus for overexpression of ARL5B

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ARL5B (see all 8)
    OriGene ORF clones in mouse, rat for ARL5B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARL5B (NM_178815)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARL5B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL5B
    Sirion Biotech Customized lentivirus for stable overexpression of ARL5B 
                         Customized lentivirus expression plasmids for stable overexpression of ARL5B 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ARL5B
    Search LifeMap BioReagents cell lines for ARL5B
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL5B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARL5B

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ARL5B (Q96KC23 ENSP000003664874) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD4Q134853, ENSP000003415514I2D: score=3 STRING: ENSP00000341551
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport ----
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007264small GTPase mediated signal transduction IEA--

    ARL5B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARL5B

    1 HMDB Compound for ARL5B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    1 DrugBank Compound for ARL5B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Guanosine-5'-Diphosphate-- 146-91-8target--10592235

    Search CenterWatch for drugs/clinical trials and news about ARL5B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARL5B gene: 
    NM_178815.3  

    Unigene Cluster for ARL5B:

    ADP-ribosylation factor-like 5B
    Hs.25362  [show with all ESTs]
    Unigene Representative Sequence: BC024163
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000377275(uc001iqd.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARL5B
    8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate ARL5B (see all 54):
    hsa-miR-4291 hsa-miR-607 hsa-miR-4328 hsa-miR-188-5p hsa-miR-15a hsa-miR-503 hsa-miR-624 hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidARL5B 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ARL5B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARL5B
    Clone
    Products:
         
    OriGene clones in human, mouse for ARL5B (see all 8)
    OriGene ORF clones in mouse, rat for ARL5B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARL5B (NM_178815)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARL5B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL5B
    Sirion Biotech Customized lentivirus for stable overexpression of ARL5B 
                         Customized lentivirus expression plasmids for stable overexpression of ARL5B 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ARL5B
    OriGene qSTAR qPCR primer pairs in human, mouse for ARL5B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARL5B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARL5B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARL5B

    Additional mRNA sequence: 

    AF494061.1 AK027275.1 BC024163.1 

    5 DOTS entries:

    DT.99942558  DT.99947259  DT.100686322  DT.121242623  DT.109194 

    24/127 AceView cDNA sequences (see all 127):

    AW270158 AV682739 AA743511 AF494061 BM352510 AW511402 BU521422 AL133611 
    CB528484 BX095548 CR625971 BQ777949 AI373429 CD677990 BX103047 AI378883 
    CA773268 CB123865 R46424 BU607841 CA315068 BM791146 AL700055 AI539336 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARL5B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTGGTTAG
    ARL5B Expression
    About this image


    See ARL5B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARL5B

    SOURCE GeneReport for Unigene cluster: Hs.25362
        SABiosciences Custom PCR Arrays for ARL5B
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ARL5B
    OriGene qSTAR qPCR primer pairs in human, mouse for ARL5B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARL5B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARL5B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARL5B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL5B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARL5B gene from 8/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arl5b1 , 5 ADP-ribosylation factor-like 5B1, 5 92.36(n)1
    100(a)1
      2 (10.98 cM)5
    758691  NM_029466.41  NP_083742.21 
     150493955 
    chicken
    (Gallus gallus)
    Aves ARL5B1 ADP-ribosylation factor-like 5B 85.29(n)
    98.32(a)
      420513  NM_001143969.1  NP_001137441.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARL5B6
    Uncharacterized protein
    99(a)
    1 ↔ 1
    6(17680690-17698645)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.52032 Xenopus laevis transcribed sequence with moderate similarity more 80.68(n)    CB591931.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi17a052 wufi17a05 81.32(n)   327551  BC052766.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG71976
    --
    71(a)
    1 → many
    3L(8291601-8292939)
    worm
    (Caenorhabditis elegans)
    Secernentea arl-56
    ADP-ribosylation factor-like protein 5
    52(a)
    1 → many
    III(9823235-9824134)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARL16
    Soluble GTPase with a role in regulation of membra...
    44(a)
    1 → many
    II(567875-568426)


    ENSEMBL Gene Tree for ARL5B (if available)
    TreeFam Gene Tree for ARL5B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARL5B gene
    ARL5C2  ARL62  ARL5A2  ARL12  
    18/30 SIMAP similar genes for ARL5B using alignment to 2 protein entries:     ARL5B_HUMAN (see all proteins) (see all similar genes):
    ARL5A    ARL5C    ARF1    ARL14    ARL17A    ARL17B
    ARF4    ARL1    ARF3    TRIM23    ARF5    ARF6
    ARL2    ARL3    ARL9    ARL10    ARL4A    ARL6

    ARL5B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ARL5B
    PGOHUM00000242062


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/434 SNPs in ARL5B are shown (see all 434)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1895210551,2
    --18950334(+) CATCCA/GGTGGC 1 -- int10--------
    rs1397182241,2
    --18950420(+) TTCCTC/GTTGGA 1 -- int10--------
    rs1810216071,2
    --18950474(+) TTCATA/GCAGCC 1 -- int10--------
    rs108291561,2
    C,F,A,H--18950555(+) AAGTAC/TTCAAA 1 -- int133Minor allele frequency- T:0.17NS EA NA WA CSA 3197
    rs1858582271,2
    --18950636(+) ATAACA/GTTGGC 1 -- int10--------
    rs1893392761,2
    --18950664(+) TTGGAA/CGTAAT 1 -- int10--------
    rs122586881,2
    C,F--18950787(+) ACTTTT/CAGGGA 1 -- int11Minor allele frequency- C:0.14WA 118
    rs775628321,2
    C--18950820(+) CTGTGC/TGTTAG 1 -- int10--------
    rs1819553021,2
    --18950824(+) GTGTTA/CGTTTG 1 -- int10--------
    rs127627521,2
    C,F--18950859(+) AGATTG/CGAAAG 1 -- int18Minor allele frequency- C:0.22NA WA EA 368

    HapMap Linkage Disequilibrium report for ARL5B (18948313 - 18970568 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ARL5B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv466762CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ARL5B
    DNA2.0 Custom Variant and Variant Library Synthesis for ARL5B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608909    OMIM disorders: --

    2 diseases for ARL5B:    About MalaCards
    alzheimer's disease    


    ARL5B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): ARL5B
    Human Genome Epidemiology (HuGE) Navigator: ARL5B (2 documents)

    Export disorders for ARL5B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARL5B gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with ARL5B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a new member of the ADP-ribosylation like factor gene family, ARL8, from a cartilage cDNA library. (PubMed id 12853149)1, 2, 3 Sebald E.... Krakow D. (2003)
    2. GWAS for discovery and replication of genetic loci as sociated with sudden cardiac arrest in patients with coronary artery disease. (PubMed id 21658281)1, 4 Aouizerat B.E....Tseng Z.H. (2011)
    3. Genome-wide association reveals genetic effects on hu man AI^42 and I8 protein levels in cerebrospinal fluids: a case control study. (PubMed id 20932310)1, 4 Han M.R....Wang L.S. (2010)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Arl5b is a Golgi-localised small G protein involved in the regulation of retrograde transport. (PubMed id 22245584)1 Houghton F.J....Gleeson P.A. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 221079 HGNC: 23052 AceView: ARL8 Ensembl:ENSG00000165997 euGenes: HUgn221079
    ECgene: ARL5B H-InvDB: ARL5B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARL5B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARL5B gene:
    Search GeneIP for patents involving ARL5B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ARL5B   OriGene RNAi products in human, mouse, rat for ARL5B  
     OriGene qPCR primer pairs and template standards for ARL5B   OriGene Protein Over-expression Lysate for ARL5B  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ARL5B  
     OriGene qSTAR qPCR primer pairs in human, mouse for ARL5B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ARL5B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ARL5B   OriGene Custom Protein Services for ARL5B  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARL5B
     QIAGEN SeqTarget long-range PCR primers for resequencing ARL5B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL5B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARL5B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARL5B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARL5B
     GenScript Custom Purified and Recombinant Proteins Services for ARL5B GenScript cDNA clones with any tag delivered in your preferred vector for ARL5B
     GenScript Custom Assay Services for ARL5B GenScript Custom Superior Antibodies Services for ARL5B
     GenScript Custom overexpressing Cell Line Services for ARL5B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ARL5B promoter
     Search Chromatin IP Primers for ARL5B
     RT2 qPCR Primer Assay in human, mouse, rat ARL5B
     Search GNC Networks for ARL5B
     SABiosciences Custom PCR Arrays for ARL5B
     Search Tocris compounds for ARL5B
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ARL5B antibodies
     ARL5B proteins
     ARL5B lysates
     Antibodies for ARL5B
     See all of Abcam's Antibodies, Kits and Proteins for ARL5B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for ARL5B




     Proteins for ARL5B
     Antibodies for ARL5B
     ELISAs for ARL5B
     CLIAs for ARL5B
     Search LifeMap BioReagents cell lines for ARL5B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL5B
     SwitchGear 3'UTR luciferase reporter plasmids for ARL5B
     SwitchGear Promoter luciferase reporter plasmids for ARL5B
     ThermoFisher Antibodies for ARL5B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL5B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ARL5B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ARL5B
    Customized:
     lentivirus for stable overexpression of ARL5B
     lentivirus expression plasmids for stable overexpression of ARL5B
     adenovirus for overexpression of ARL5B
     LSBio Antibodies in human, mouse, rat for ARL5B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ARL5B gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4