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ARL5B Gene

protein-coding   GIFtS: 55
GCID: GC10P018948

ADP-Ribosylation Factor-Like 5B

(Previous name: ADP-ribosylation factor-like 8)
(Previous symbol: ARL8)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADP-Ribosylation Factor-Like 5B1 2
ARL81 2 3 5
ADP-Ribosylation Factor-Like 81 2
ADP-Ribosylation Factor-Like Protein 82 3
ADP-Ribosylation Factor-Like Protein 5B2
ADP-Ribosylation-Like Factor 82

External Ids:    HGNC: 230521   Entrez Gene: 2210792   Ensembl: ENSG000001659977   OMIM: 6089095   UniProtKB: Q96KC23   

Export aliases for ARL5B gene to outside databases

Previous GC identifers: GC10P018989 GC10P018608


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARL5B Gene:
ARL5B (ARL8) belongs to a family of proteins that are structurally similar to ADP-ribosylation factors (ARFs; see
MIM 103180). ARLs and ARFs are part of the RAS superfamily of regulatory GTPases.(supplied by OMIM, Nov 2010)

GeneCards Summary for ARL5B Gene:
ARL5B (ADP-ribosylation factor-like 5B) is a protein-coding gene. Diseases associated with ARL5B include coronary artery disease, and alzheimer's disease. GO annotations related to this gene include GTP binding. An important paralog of this gene is ARL2.

UniProtKB/Swiss-Prot: ARL5B_HUMAN, Q96KC2
Function: Binds and exchanges GTP and GDP




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_008705.17  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARL5B gene promoter:
         Oct-B1   oct-B3   oct-B2   AML1a   p53   CREB   POU2F1   deltaCREB   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARL5B promoter sequence
   Search Chromatin IP Primers for ARL5B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARL5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.31   Ensembl cytogenetic band:  10p12.31   HGNC cytogenetic band: 10p13

ARL5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL5B gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P018948:  view genomic region     (about GC identifiers)

Start:
18,948,313 bp from pter      End:
18,970,568 bp from pter
Size:
22,256 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARL5B_HUMAN, Q96KC2 (See protein sequence)
Recommended Name: ADP-ribosylation factor-like protein 5B  
Size: 179 amino acids; 20375 Da
1 PDB 3D structure from and Proteopedia for ARL5B:
1YZG (3D)    

Explore the universe of human proteins at neXtProt for ARL5B: NX_Q96KC2

Explore proteomics data for ARL5B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys103
  • Modification sites at PhosphoSitePlus

  • See ARL5B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_848930.1  
    ENSEMBL proteins: 
     ENSP00000366487  

    ARL5B Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARL: ADP-ribosylation factors-like
    ARF: ADP-ribosylation factors

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR027417 P-loop_NTPase
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF

    Graphical View of Domain Structure for InterPro Entry Q96KC2

    ProtoNet protein and cluster: Q96KC2

    1 Blocks protein domain: IPB006688 ADP-ribosylation factor

    UniProtKB/Swiss-Prot: ARL5B_HUMAN, Q96KC2
    Similarity: Belongs to the small GTPase superfamily. Arf family


    ARL5B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARL5B_HUMAN, Q96KC2
    Function: Binds and exchanges GTP and GDP

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0004871signal transducer activity ----
    GO:0005525GTP binding IEA--
    GO:0019001guanyl nucleotide binding ----
    GO:0031683G-protein beta/gamma-subunit complex binding ----
         
    ARL5B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ARL5B:
     Decreased viability of wild-ty 

         1 MGI phenotypic allele for Arl5b (no phenotypes)

    ARL5B for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARL5B
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    miRNA
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    miRTarBase miRNAs that target ARL5B:
    hsa-mir-155-5p (MIRT001567), hsa-mir-186-5p (MIRT044984), hsa-mir-335-5p (MIRT017382)

    Block miRNA regulation of human, mouse, rat ARL5B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARL5B (see all 54):
    hsa-miR-4291 hsa-miR-607 hsa-miR-4328 hsa-miR-188-5p hsa-miR-15a hsa-miR-503 hsa-miR-624 hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidARL5B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARL5B

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL5B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    extracellular2
    cytoskeleton1
    endosome1
    lysosome1
    mitochondrion1
    nucleus1
    vacuole1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----

    ARL5B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARL5B
    Interactions:

        Search GeneGlobe Interaction Network for ARL5B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for ARL5B (Q96KC23 ENSP000003664874) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD4Q134853, ENSP000003415514I2D: score=3 STRING: ENSP00000341551
    UBCENSP000003448184STRING: ENSP00000344818
    ARF4ENSP000003060104STRING: ENSP00000306010
    ARF5ENSP000000002334STRING: ENSP00000000233
    ARL3ENSP000002607464STRING: ENSP00000260746
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport ----
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007264small GTPase mediated signal transduction IEA--

    ARL5B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARL5B

    1 HMDB Compound for ARL5B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    1 DrugBank Compound for ARL5B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Guanosine-5'-Diphosphate-- 146-91-8target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARL5B gene: 
    NM_178815.3  

    Unigene Cluster for ARL5B:

    ADP-ribosylation factor-like 5B
    Hs.25362  [show with all ESTs]
    Unigene Representative Sequence: BC024163
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000377275(uc001iqd.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ARL5B (see all 54):
    hsa-miR-4291 hsa-miR-607 hsa-miR-4328 hsa-miR-188-5p hsa-miR-15a hsa-miR-503 hsa-miR-624 hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidARL5B 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL5B
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARL5B
      QuantiTect SYBR Green Assays in human, mouse, rat ARL5B
      QuantiFast Probe-based Assays in human, mouse, rat ARL5B

    Additional mRNA sequence: 

    AF494061.1 AK027275.1 BC024163.1 

    5 DOTS entries:

    DT.99942558  DT.99947259  DT.100686322  DT.121242623  DT.109194 

    Selected AceView cDNA sequences (see all 127):

    AI373429 BM995598 AW511402 CA315068 BM352510 AF494061 CA773268 AI378883 
    CD677990 BQ286688 AL133611 AA743511 BU607841 BX103047 BU521422 AW270158 
    CB123865 CR625971 AV682739 BQ777949 CB528484 R46424 AI277332 AW440353 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARL5B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTGGTTAG
    ARL5B Expression
    About this image

    ARL5B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARL5B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.25362
        Custom PCR Arrays for ARL5B
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARL5B gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arl5b1 , 5 ADP-ribosylation factor-like 5B1, 5 92.36(n)1
    100(a)1
      2 (10.98 cM)5
    758691  NM_029466.41  NP_083742.21 
     150493955 
    chicken
    (Gallus gallus)
    Aves ARL5B1 ADP-ribosylation factor-like 5B 85.29(n)
    98.32(a)
      420513  NM_001143969.1  NP_001137441.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARL5B6
    ADP-ribosylation factor-like 5B
    99(a)
    1 ↔ 1
    6(17680690-17698645)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.52032 Xenopus laevis transcribed sequence with moderate similarity more 80.68(n)    CB591931.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi17a052 wufi17a05 81.32(n)   327551  BC052766.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG71976
    --
    71(a)
    1 → many
    3L(8291601-8292939)
    worm
    (Caenorhabditis elegans)
    Secernentea arl-56
    Protein ARL-5 (arl-5) mRNA, complete cds
    52(a)
    1 → many
    III(9823235-9824134) WBGene00000189


    ENSEMBL Gene Tree for ARL5B (if available)
    TreeFam Gene Tree for ARL5B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARL5B gene
    ARL22  ENSG000002730032  ARL5C2  ARF42  ENSG000002728222  ARF52  ARF12  ARL32  
    ARL5A2  ARF32  ARF62  TRIM232  
    Selected SIMAP similar genes for ARL5B using alignment to 2 protein entries:     ARL5B_HUMAN (see all proteins) (see all similar genes):
    ARL5A    ARL5C    ARF1    ARL14    ARL17A    ARL17B
    ARF4    ARL1    TRIM23    ARF5    ARF6    ARL2
    ARL3    ARL9    ARF3    ARL10    ARL4A    ARL6

    ARL5B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ARL5B
    PGOHUM00000242062


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARL5B (see all 434)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1895210551,2
    --18950334(+) CATCCA/GGTGGC 1 -- int10--------
    rs1397182241,2
    --18950420(+) TTCCTC/GTTGGA 1 -- int10--------
    rs1810216071,2
    --18950474(+) TTCATA/GCAGCC 1 -- int10--------
    rs108291561,2
    C,F,A,H--18950555(+) AAGTAC/TTCAAA 1 -- int133Minor allele frequency- T:0.17NS EA NA WA CSA 3197
    rs1858582271,2
    --18950636(+) ATAACA/GTTGGC 1 -- int10--------
    rs1893392761,2
    --18950664(+) TTGGAA/CGTAAT 1 -- int10--------
    rs122586881,2
    C,F--18950787(+) ACTTTT/CAGGGA 1 -- int11Minor allele frequency- C:0.14WA 118
    rs775628321,2
    C--18950820(+) CTGTGC/TGTTAG 1 -- int10--------
    rs1819553021,2
    --18950824(+) GTGTTA/CGTTTG 1 -- int10--------
    rs127627521,2
    C,F--18950859(+) AGATTG/CGAAAG 1 -- int18Minor allele frequency- C:0.22NA WA EA 368

    HapMap Linkage Disequilibrium report for ARL5B (18948313 - 18970568 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ARL5B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv466762CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARL5B
    DNA2.0 Custom Variant and Variant Library Synthesis for ARL5B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608909    OMIM disorders: --

    2 diseases for ARL5B:    
    About MalaCards
    coronary artery disease    alzheimer's disease


    ARL5B for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARL5B
    Human Genome Epidemiology (HuGE) Navigator: ARL5B (2 documents)

    Export disorders for ARL5B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARL5B gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with ARL5B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a new member of the ADP-ribosylation like factor gene family, ARL8, from a cartilage cDNA library. (PubMed id 12853149)1, 2, 3 Sebald E.... Krakow D. (Gene 2003)
    2. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PubMed id 21658281)1, 4 Aouizerat B.E....Tseng Z.H. (BMC Cardiovasc Disord 2011)
    3. Genome-wide association reveals genetic effects on human AI^42 and I8 protein levels in cerebrospinal fluids: a case control study. (PubMed id 20932310)1, 4 Han M.R....Wang L.S. (BMC Neurol 2010)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Arl5b is a Golgi-localised small G protein involved in the regulation of retrograde transport. (PubMed id 22245584)1 Houghton F.J....Gleeson P.A. (Exp. Cell Res. 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 221079 HGNC: 23052 AceView: ARL8 Ensembl:ENSG00000165997 euGenes: HUgn221079
    ECgene: ARL5B H-InvDB: ARL5B

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARL5B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARL5B gene:
    Search GeneIP for patents involving ARL5B

    GeneCards and IP:
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