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Aliases for ARL5B Gene

Aliases for ARL5B Gene

  • ADP-Ribosylation Factor-Like 5B 2 3
  • ARL8 3 4 6
  • ADP-Ribosylation Factor-Like Protein 8 3 4
  • ADP-Ribosylation Factor-Like 8 2 3
  • ADP-Ribosylation Factor-Like Protein 5B 3
  • ADP-Ribosylation-Like Factor 8 3

External Ids for ARL5B Gene

Previous Symbols for ARL5B Gene

  • ARL8

Summaries for ARL5B Gene

Entrez Gene Summary for ARL5B Gene

  • ARL5B (ARL8) belongs to a family of proteins that are structurally similar to ADP-ribosylation factors (ARFs; see MIM 103180). ARLs and ARFs are part of the RAS superfamily of regulatory GTPases.[supplied by OMIM, Nov 2010]

GeneCards Summary for ARL5B Gene

ARL5B (ADP-Ribosylation Factor-Like 5B) is a Protein Coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is ENSG00000272822.

UniProtKB/Swiss-Prot for ARL5B Gene

  • Binds and exchanges GTP and GDP

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL5B Gene

Genomics for ARL5B Gene

Genomic Location for ARL5B Gene

Start:
18,659,335 bp from pter
End:
18,681,639 bp from pter
Size:
22,305 bases
Orientation:
Plus strand

Genomic View for ARL5B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARL5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL5B Gene

Regulatory Elements for ARL5B Gene

Proteins for ARL5B Gene

  • Protein details for ARL5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KC2-ARL5B_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 5B
    Protein Accession:
    Q96KC2
    Secondary Accessions:

    Protein attributes for ARL5B Gene

    Size:
    179 amino acids
    Molecular mass:
    20375 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ARL5B Gene

neXtProt entry for ARL5B Gene

Proteomics data for ARL5B Gene at MOPED

Post-translational modifications for ARL5B Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys103

Other Protein References for ARL5B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARL5B Gene

Domains for ARL5B Gene

Gene Families for ARL5B Gene

HGNC:
  • ARL :ADP-ribosylation factors-like
  • ARF :ADP-ribosylation factors

Protein Domains for ARL5B Gene

Suggested Antigen Peptide Sequences for ARL5B Gene

Graphical View of Domain Structure for InterPro Entry

Q96KC2

UniProtKB/Swiss-Prot:

ARL5B_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Arf family.:
    • Q96KC2
genes like me logo Genes that share domains with ARL5B: view

Function for ARL5B Gene

Molecular function for ARL5B Gene

UniProtKB/Swiss-Prot Function: Binds and exchanges GTP and GDP

Gene Ontology (GO) - Molecular Function for ARL5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity --
GO:0004871 signal transducer activity --
GO:0005525 GTP binding IEA --
GO:0019001 guanyl nucleotide binding --
GO:0031683 G-protein beta/gamma-subunit complex binding --
genes like me logo Genes that share ontologies with ARL5B: view

Phenotypes for ARL5B Gene

genes like me logo Genes that share phenotypes with ARL5B: view

miRNA for ARL5B Gene

miRTarBase miRNAs that target ARL5B

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARL5B Gene

Localization for ARL5B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARL5B Gene COMPARTMENTS Subcellular localization image for ARL5B gene
Compartment Confidence
cytosol 2
extracellular 2
cytoskeleton 1
endosome 1
lysosome 1
mitochondrion 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ARL5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with ARL5B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARL5B Gene

Pathways for ARL5B Gene

SuperPathways for ARL5B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with ARL5B: view

No data available for Pathways by source for ARL5B Gene

Compounds for ARL5B Gene

(1) HMDB Compounds for ARL5B Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(1) Drugbank Compounds for ARL5B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Guanosine-5'-Diphosphate
146-91-8 target
genes like me logo Genes that share compounds with ARL5B: view

Transcripts for ARL5B Gene

mRNA/cDNA for ARL5B Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(127) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARL5B Gene

ADP-ribosylation factor-like 5B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARL5B Gene

No ASD Table

Relevant External Links for ARL5B Gene

GeneLoc Exon Structure for
ARL5B
ECgene alternative splicing isoforms for
ARL5B

Expression for ARL5B Gene

mRNA expression in normal human tissues for ARL5B Gene

mRNA differential expression in normal tissues according to GTEx for ARL5B Gene

This gene is overexpressed in Liver (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARL5B Gene

SOURCE GeneReport for Unigene cluster for ARL5B Gene Hs.25362

genes like me logo Genes that share expressions with ARL5B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ARL5B Gene

Orthologs for ARL5B Gene

This gene was present in the common ancestor of animals.

Orthologs for ARL5B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARL5B 35
  • 100 (n)
  • 100 (a)
ARL5B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARL5B 35
  • 96.46 (n)
  • 100 (a)
ARL5B 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARL5B 35
  • 95.53 (n)
  • 100 (a)
ARL5B 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arl5b 35
  • 92.36 (n)
  • 100 (a)
Arl5b 16
Arl5b 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARL5B 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARL5B 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARL5B 35
  • 85.29 (n)
  • 98.32 (a)
ARL5B 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARL5B 36
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5203 35
tropical clawed frog
(Silurana tropicalis)
Amphibia arl5a 35
  • 82.31 (n)
  • 94.41 (a)
zebrafish
(Danio rerio)
Actinopterygii arl8 35
  • 81.01 (n)
  • 94.97 (a)
arl8 36
  • 96 (a)
OneToOne
wufi17a05 35
fruit fly
(Drosophila melanogaster)
Insecta CG7197 36
  • 71 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea arl-5 36
  • 52 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11870 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
ManyToMany
Species with no ortholog for ARL5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARL5B Gene

ENSEMBL:
Gene Tree for ARL5B (if available)
TreeFam:
Gene Tree for ARL5B (if available)

Paralogs for ARL5B Gene

Pseudogenes.org Pseudogenes for ARL5B Gene

genes like me logo Genes that share paralogs with ARL5B: view

Variants for ARL5B Gene

Sequence variations from dbSNP and Humsavar for ARL5B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1055114 -- 18,677,812(+) TGTTT(C/T)ATATC utr-variant-3-prime
rs1055115 -- 18,677,878(+) ACCCA(A/C)CTACA utr-variant-3-prime
rs1055116 -- 18,677,938(+) AATTT(C/T)AACAG utr-variant-3-prime
rs1108851 -- 18,674,872(-) CTTAA(C/T)GACTG intron-variant
rs1626860 -- 18,664,548(+) ttctt(C/G)tgctt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARL5B Gene

Variant ID Type Subtype PubMed ID
nsv466762 CNV Gain 19166990

Relevant External Links for ARL5B Gene

HapMap Linkage Disequilibrium report
ARL5B
Human Gene Mutation Database (HGMD)
ARL5B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL5B Gene

Disorders for ARL5B Gene

Relevant External Links for ARL5B

Genetic Association Database (GAD)
ARL5B
Human Genome Epidemiology (HuGE) Navigator
ARL5B
genes like me logo Genes that share disorders with ARL5B: view

No data available for UniProtKB/Swiss-Prot for ARL5B Gene

Publications for ARL5B Gene

  1. Isolation of a new member of the ADP-ribosylation like factor gene family, ARL8, from a cartilage cDNA library. (PMID: 12853149) Sebald E. … Krakow D. (Gene 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat B.E. … Tseng Z.H. (BMC Cardiovasc Disord 2011) 3 48
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48

Products for ARL5B Gene

  • Addgene plasmids for ARL5B

Sources for ARL5B Gene

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