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Aliases for ARL5A Gene

Aliases for ARL5A Gene

  • ADP-Ribosylation Factor-Like 5A 2 3
  • ARL5 3 4 6
  • ADP-Ribosylation Factor-Like 5 2 3
  • ARFLP5 3 4
  • ADP-Ribosylation Factor-Like Protein 5A 3
  • ADP-Ribosylation Factor-Like Protein 5 3

External Ids for ARL5A Gene

Previous Symbols for ARL5A Gene

  • ARL5

Summaries for ARL5A Gene

Entrez Gene Summary for ARL5A Gene

  • The protein encoded by this gene belongs to the ARF family of GTP-binding proteins. With its distinctive nuclear/nucleolar localization and interaction with HP1alpha, the protein is developmentally regulated and may play a role(s) in nuclear dynamics and/or signaling cascades during embryonic development. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARL5A Gene

ARL5A (ADP-Ribosylation Factor-Like 5A) is a Protein Coding gene. Diseases associated with ARL5A include prostate carcinoma in situ. GO annotations related to this gene include GTP binding. An important paralog of this gene is ENSG00000272822.

UniProtKB/Swiss-Prot for ARL5A Gene

  • Lacks ADP-ribosylation enhancing activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL5A Gene

Genomics for ARL5A Gene

Genomic Location for ARL5A Gene

Start:
151,788,984 bp from pter
End:
151,828,495 bp from pter
Size:
39,512 bases
Orientation:
Minus strand

Genomic View for ARL5A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARL5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL5A Gene

Regulatory Elements for ARL5A Gene

Proteins for ARL5A Gene

  • Protein details for ARL5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y689-ARL5A_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 5A
    Protein Accession:
    Q9Y689
    Secondary Accessions:
    • Q580I5

    Protein attributes for ARL5A Gene

    Size:
    179 amino acids
    Molecular mass:
    20728 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ARL5A Gene

    Alternative splice isoforms for ARL5A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARL5A Gene

Proteomics data for ARL5A Gene at MOPED

Post-translational modifications for ARL5A Gene

No Post-translational modifications

Other Protein References for ARL5A Gene

No data available for DME Specific Peptides for ARL5A Gene

Domains for ARL5A Gene

Gene Families for ARL5A Gene

HGNC:
  • ARL :ADP-ribosylation factors-like
  • ARF :ADP-ribosylation factors

Protein Domains for ARL5A Gene

UniProtKB/Swiss-Prot:

ARL5A_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Arf family.:
    • Q9Y689
genes like me logo Genes that share domains with ARL5A: view

Function for ARL5A Gene

Molecular function for ARL5A Gene

UniProtKB/Swiss-Prot Function: Lacks ADP-ribosylation enhancing activity.

Gene Ontology (GO) - Molecular Function for ARL5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity --
GO:0004871 signal transducer activity --
GO:0005525 GTP binding IEA --
GO:0019001 guanyl nucleotide binding --
GO:0031683 G-protein beta/gamma-subunit complex binding --
genes like me logo Genes that share ontologies with ARL5A: view

miRNA for ARL5A Gene

miRTarBase miRNAs that target ARL5A

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARL5A Gene

Localization for ARL5A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARL5A Gene COMPARTMENTS Subcellular localization image for ARL5A gene
Compartment Confidence
cytosol 3
cytoskeleton 1
endosome 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ARL5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with ARL5A: view

Pathways for ARL5A Gene

SuperPathways for ARL5A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with ARL5A: view

No data available for Pathways by source for ARL5A Gene

Compounds for ARL5A Gene

(1) Drugbank Compounds for ARL5A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Guanosine-5'-Diphosphate
146-91-8 target
genes like me logo Genes that share compounds with ARL5A: view

Transcripts for ARL5A Gene

Unigene Clusters for ARL5A Gene

ADP-ribosylation factor-like 5A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARL5A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: -
SP3: -
SP4:

Relevant External Links for ARL5A Gene

GeneLoc Exon Structure for
ARL5A
ECgene alternative splicing isoforms for
ARL5A

Expression for ARL5A Gene

mRNA expression in normal human tissues for ARL5A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARL5A Gene

SOURCE GeneReport for Unigene cluster for ARL5A Gene Hs.470233

genes like me logo Genes that share expressions with ARL5A: view

Orthologs for ARL5A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARL5A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARL5A 36
  • 99.63 (n)
  • 100 (a)
ARL5A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARL5A 36
  • 96.46 (n)
  • 99.44 (a)
ARL5A 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARL5A 36
  • 96.95 (n)
  • 100 (a)
ARL5A 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arl5a 36
  • 90.88 (n)
  • 98.88 (a)
Arl5a 16
Arl5a 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARL5A 37
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARL5A 37
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arl5a 36
  • 92.36 (n)
  • 99.44 (a)
chicken
(Gallus gallus)
Aves ARL5A 37
  • 89 (a)
OneToOne
LOC100857935 36
  • 85.16 (n)
  • 97.56 (a)
lizard
(Anolis carolinensis)
Reptilia ARL5A 37
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490823 36
  • 80.63 (n)
  • 92.74 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1360 36
zebrafish
(Danio rerio)
Actinopterygii arl5a 36
  • 78.4 (n)
  • 92.18 (a)
arl5a 37
  • 92 (a)
OneToOne
Dr.11356 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011254 36
  • 64.57 (n)
  • 73.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7197 36
  • 64.97 (n)
  • 72.88 (a)
CG7197 37
  • 72 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea arl-5 37
  • 50 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5206 36
thale cress
(Arabidopsis thaliana)
eudicotyledons ARFC1 36
  • 61.55 (n)
  • 57.39 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.1404 36
rice
(Oryza sativa)
Liliopsida Os11g0586900 36
  • 55.49 (n)
  • 57.39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 37 (a)
ManyToMany
Species with no ortholog for ARL5A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARL5A Gene

ENSEMBL:
Gene Tree for ARL5A (if available)
TreeFam:
Gene Tree for ARL5A (if available)

Paralogs for ARL5A Gene

Selected SIMAP similar genes for ARL5A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARL5A: view

Variants for ARL5A Gene

Sequence variations from dbSNP and Humsavar for ARL5A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1054883 -- 151,801,335(-) CTTGG(A/T)TTACT utr-variant-3-prime
rs1357468 -- 151,827,217(+) ATAAG(C/T)ATCCA intron-variant
rs1523181 -- 151,822,948(+) TAATA(C/T)ATATT intron-variant
rs1568674 -- 151,820,291(+) TAAAT(A/C)TTTCT intron-variant
rs2030588 -- 151,812,236(+) TGGCC(A/C)GCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARL5A Gene

Variant ID Type Subtype PubMed ID
esv34659 CNV Loss 17911159
nsv820167 CNV Loss 19587683

Relevant External Links for ARL5A Gene

HapMap Linkage Disequilibrium report
ARL5A

Disorders for ARL5A Gene

(1) University of Copenhagen DISEASES for ARL5A Gene

genes like me logo Genes that share disorders with ARL5A: view

No data available for UniProtKB/Swiss-Prot for ARL5A Gene

Publications for ARL5A Gene

  1. A developmentally regulated ARF-like 5 protein (ARL5), localized to nuclei and nucleoli, interacts with heterochromatin protein 1. (PMID: 12414990) Lin C.Y. … Lee F.J. (J. Cell. Sci. 2002) 3 23
  2. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  3. Identification and characterization of nine novel human small GTPases showing variable expressions in liver cancer tissues. (PMID: 12450215) He H. … Zhao S.Y. (Gene Expr. 2002) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. 2.0 A crystal structure of human ARL5-GDP3'P, a novel member of the small GTP-binding proteins. (PMID: 15896705) Wang Z.-X. … Liang D.-C. (Biochem. Biophys. Res. Commun. 2005) 3 4

Products for ARL5A Gene

  • Addgene plasmids for ARL5A

Sources for ARL5A Gene

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