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Aliases for ARL5A Gene

Aliases for ARL5A Gene

  • ADP Ribosylation Factor Like GTPase 5A 2 3 5
  • ADP-Ribosylation Factor-Like 5A 2 3
  • ADP-Ribosylation Factor-Like 5 2 3
  • ARFLP5 3 4
  • ARL5 3 4
  • ADP-Ribosylation Factor Like GTPase 5A 3
  • ADP-Ribosylation Factor-Like Protein 5 3

External Ids for ARL5A Gene

Previous HGNC Symbols for ARL5A Gene

  • ARL5

Previous GeneCards Identifiers for ARL5A Gene

  • GC02M152485
  • GC02M152365
  • GC02M152645
  • GC02M144543

Summaries for ARL5A Gene

Entrez Gene Summary for ARL5A Gene

  • The protein encoded by this gene belongs to the ARF family of GTP-binding proteins. With its distinctive nuclear/nucleolar localization and interaction with HP1alpha, the protein is developmentally regulated and may play a role(s) in nuclear dynamics and/or signaling cascades during embryonic development. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARL5A Gene

ARL5A (ADP Ribosylation Factor Like GTPase 5A) is a Protein Coding gene. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is ENSG00000272822.

UniProtKB/Swiss-Prot for ARL5A Gene

  • Lacks ADP-ribosylation enhancing activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL5A Gene

Genomics for ARL5A Gene

Regulatory Elements for ARL5A Gene

Promoters for ARL5A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARL5A on UCSC Golden Path with GeneCards custom track

Genomic Location for ARL5A Gene

Chromosome:
2
Start:
151,788,984 bp from pter
End:
151,828,495 bp from pter
Size:
39,512 bases
Orientation:
Minus strand

Genomic View for ARL5A Gene

Genes around ARL5A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL5A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL5A Gene

Proteins for ARL5A Gene

  • Protein details for ARL5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y689-ARL5A_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 5A
    Protein Accession:
    Q9Y689
    Secondary Accessions:
    • Q580I5

    Protein attributes for ARL5A Gene

    Size:
    179 amino acids
    Molecular mass:
    20728 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ARL5A Gene

    Alternative splice isoforms for ARL5A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARL5A Gene

Proteomics data for ARL5A Gene at MOPED

Post-translational modifications for ARL5A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARL5A Gene

No data available for DME Specific Peptides for ARL5A Gene

Domains & Families for ARL5A Gene

Gene Families for ARL5A Gene

Protein Domains for ARL5A Gene

Suggested Antigen Peptide Sequences for ARL5A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y689

UniProtKB/Swiss-Prot:

ARL5A_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL5A: view

Function for ARL5A Gene

Molecular function for ARL5A Gene

UniProtKB/Swiss-Prot Function:
Lacks ADP-ribosylation enhancing activity.
genes like me logo Genes that share phenotypes with ARL5A: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL5A Gene

Localization for ARL5A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARL5A Gene COMPARTMENTS Subcellular localization image for ARL5A gene
Compartment Confidence
cytosol 3
endosome 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ARL5A Gene

Pathways & Interactions for ARL5A Gene

SuperPathways for ARL5A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL5A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ARL5A Gene

Drugs & Compounds for ARL5A Gene

(1) Drugs for ARL5A Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma Target 0
genes like me logo Genes that share compounds with ARL5A: view

Transcripts for ARL5A Gene

Unigene Clusters for ARL5A Gene

ADP-ribosylation factor-like 5A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL5A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: -
SP3: -
SP4:

Relevant External Links for ARL5A Gene

GeneLoc Exon Structure for
ARL5A
ECgene alternative splicing isoforms for
ARL5A

Expression for ARL5A Gene

mRNA expression in normal human tissues for ARL5A Gene

Protein differential expression in normal tissues from HIPED for ARL5A Gene

This gene is overexpressed in Bone (41.7) and Oral epithelium (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARL5A Gene



SOURCE GeneReport for Unigene cluster for ARL5A Gene Hs.470233

genes like me logo Genes that share expression patterns with ARL5A: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ARL5A Gene

Orthologs for ARL5A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARL5A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARL5A 35
  • 96.46 (n)
  • 99.44 (a)
ARL5A 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARL5A 35
  • 96.95 (n)
  • 100 (a)
ARL5A 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arl5a 35
  • 90.88 (n)
  • 98.88 (a)
Arl5a 16
Arl5a 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARL5A 35
  • 99.63 (n)
  • 100 (a)
ARL5A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arl5a 35
  • 92.36 (n)
  • 99.44 (a)
oppossum
(Monodelphis domestica)
Mammalia ARL5A 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARL5A 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857935 35
  • 85.16 (n)
  • 97.56 (a)
ARL5A 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARL5A 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490823 35
  • 80.63 (n)
  • 92.74 (a)
zebrafish
(Danio rerio)
Actinopterygii arl5a 35
  • 78.4 (n)
  • 92.18 (a)
Dr.11356 35
arl5a 36
  • 92 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1360 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011254 35
  • 64.57 (n)
  • 73.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7197 35
  • 64.97 (n)
  • 72.88 (a)
CG7197 36
  • 72 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea arl-5 36
  • 50 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ARFC1 35
  • 61.55 (n)
  • 57.39 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5206 35
barley
(Hordeum vulgare)
Liliopsida Hv.1404 35
rice
(Oryza sativa)
Liliopsida Os11g0586900 35
  • 55.49 (n)
  • 57.39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
ManyToMany
Species with no ortholog for ARL5A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARL5A Gene

ENSEMBL:
Gene Tree for ARL5A (if available)
TreeFam:
Gene Tree for ARL5A (if available)

Paralogs for ARL5A Gene

(27) SIMAP similar genes for ARL5A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARL5A: view

Variants for ARL5A Gene

Sequence variations from dbSNP and Humsavar for ARL5A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1054883 -- 151,801,335(-) CTTGG(A/T)TTACT utr-variant-3-prime
rs1357468 -- 151,827,217(+) ATAAG(C/T)ATCCA intron-variant
rs1568674 -- 151,820,291(+) TAAAT(A/C)TTTCT intron-variant
rs1523181 -- 151,822,948(+) TAATA(C/T)ATATT intron-variant
rs2272126 -- 151,815,285(+) TCTCA(C/G)CCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARL5A Gene

Variant ID Type Subtype PubMed ID
esv34659 CNV Loss 17911159
nsv820167 CNV Loss 19587683

Variation tolerance for ARL5A Gene

Residual Variation Intolerance Score: 43.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARL5A Gene

HapMap Linkage Disequilibrium report
ARL5A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL5A Gene

Disorders for ARL5A Gene

Relevant External Links for ARL5A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARL5A

No disorders were found for ARL5A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL5A Gene

Publications for ARL5A Gene

  1. 2.0 A crystal structure of human ARL5-GDP3'P, a novel member of the small GTP-binding proteins. (PMID: 15896705) Wang Z.-X. … Liang D.-C. (Biochem. Biophys. Res. Commun. 2005) 2 3 4 67
  2. A developmentally regulated ARF-like 5 protein (ARL5), localized to nuclei and nucleoli, interacts with heterochromatin protein 1. (PMID: 12414990) Lin C.Y. … Lee F.J. (J. Cell. Sci. 2002) 3 23
  3. microRNA-202-3p inhibits cell proliferation by targeting ADP-ribosylation factor-like 5A in human colorectal carcinoma. (PMID: 24327274) Wang Q. … Du X. (Clin. Cancer Res. 2014) 3
  4. Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation. (PMID: 25496667) Landi A. … Verhasselt B. (Retrovirology 2014) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for ARL5A Gene

Sources for ARL5A Gene

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