ARL5A Gene
protein-coding GIFtS: 49
GCID: GC02M152645
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ADP-ribosylation factor-like 5A(Previous name: ADP-ribosylation factor-like 5 )
(Previous symbol: ARL5)
| |
Aliases
for ARL5A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ADP-Ribosylation Factor-Like 5A1 2 | | ARL51 2 3 5 | | ADP-Ribosylation Factor-Like 51 2 | | ARFLP52 3 | | ADP-Ribosylation Factor-Like Protein 52 | | ADP-Ribosylation Factor-Like Protein 5A2 |
Export aliases for ARL5A gene to outside databasesPrevious GC identifers: GC02M152485 GC02M152365 GC02M144543 |
Summaries
for ARL5A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ARL5A:
The protein encoded by this gene belongs to the ARF family of GTP-binding proteins. With its distinctivenuclear/nucleolar localization and interaction with HP1alpha, the protein is developmentally regulated and may play arole(s) in nuclear dynamics and/or signaling cascades during embryonic development. Alternative splicing results inmultiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: ARL5A_HUMAN, Q9Y689Function: Lacks ADP-ribosylation enhancing activity (By similarity)
|
Genomic Views
for ARL5A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ARL5A gene promoter:
TBP POU3F2 Evi-1 Pax-3 POU2F1 POU2F1a TFIID POU2F1b
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARL5A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL5A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q23.3 Ensembl cytogenetic band: 2q23.3 HGNC cytogenetic band: 2q23.3ARL5A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M152645: view genomic region
(about GC identifiers)
Start:
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152,645,498 bp from pter |
End:
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152,685,009 bp from pter |
Size:
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39,512 bases |
Orientation:
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minus strand |
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Proteins
for ARL5A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ARL5A_HUMAN, Q9Y689 (See
protein sequence)Recommended Name: ADP-ribosylation factor-like protein 5A Size: 179 amino acids; 20728 Da
4 PDB 3D structures from  and Proteopedia  for ARL5A:1Z6Y (3D)
1ZJ6 (3D)
2H16 (3D)
2H17 (3D)
Secondary accessions: Q580I5Alternative splicing: 2 isoforms: Q9Y689-1 Q9Y689-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ARL5A: NX_Q9Y689
ARL5A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001032251.1 NP_036229.1 NP_817114.2
ENSEMBL proteins: ENSP00000394626 ENSP00000295087 ENSP00000406276 ENSP00000393716 ENSP00000415950
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
ARL5A for ontologies About GeneDecksing
ARL5A Antibody Products:
Assay Products for ARL5A: |
Protein
Domains /
Families
for ARL5A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARL5A for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y689ProtoNet protein and cluster: Q9Y689 1 Blocks protein family: IPB006688 ADP-ribosylation factor
UniProtKB/Swiss-Prot: ARL5A_HUMAN, Q9Y689Similarity: Belongs to the small GTPase superfamily. Arf family |
Function
for ARL5A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ARL5A_HUMAN, Q9Y689Function: Lacks ADP-ribosylation enhancing activity (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARL5A (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARL5A (see all 3)
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Synthesis Service for ARL5A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL5A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL5A |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005525 | GTP binding |
IEA | -- |
ARL5A for ontologies About GeneDecksing
|
Pathways & Interactions
for ARL5A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARL5A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/9 Interacting proteins for ARL5A (Q9Y6893 ENSP000002950874) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
IEA | -- |
ARL5A for ontologies About GeneDecksing
|
Drugs & Compounds
for ARL5A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ARL5A
1 DrugBank Compound for ARL5A About this table
Search CenterWatch for drugs/clinical trials and news about ARL5A
|
Transcripts
for ARL5A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ARL5A gene (3 alternative transcripts): NM_001037174.1 NM_012097.3 NM_177985.2 Unigene Cluster for ARL5A: ADP-ribosylation factor-like 5A Hs.470233 [show with all ESTs]Unigene Representative Sequence: NM_0120978 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000495604 ENST00000446896(uc010zcc.2) ENST00000487818 ENST00000295087(uc002txx.1)
ENST00000452215(uc002txv.1) ENST00000458140 ENST00000487723 ENST00000428992(uc002txw.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARL5A (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARL5A (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): ARL5A (NM_012097) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARL5A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL5A |
Additional cDNA sequence: AF100740.1 AF493891.1 AK292714.1 AK298937.1 BC001254.1 BT009829.1 10 DOTS entries: DT.85105546 DT.95178012 DT.100799686 DT.100699574 DT.95178009 DT.95361835 DT.100799693 DT.306177 DT.92443320 DT.95076761 24/253 AceView cDNA sequences (see all 253): BG149727 BX103836 AF493891 BU521684 BF001635 AI492015 AF100740 BM069448 CA945136 CR613929 BQ024476 CD251039 BM800611 AA987360 CB069758 AI344473 BF149213 AI918813 AI472236 AW473831 NM_177985 AA361345 CD369499 BF477644
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for ARL5A About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c |
|---|
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| SP1: | | | | | | | - | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ARL5A
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Expression
for ARL5A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARL5A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGTGCTCTA
About this image
See ARL5A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARL5A
SOURCE GeneReport for Unigene cluster: Hs.470233
SABiosciences Custom PCR Arrays for ARL5A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARL5A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARL5A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARL5A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARL5A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL5A |
Orthologs
for ARL5A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ARL5A gene from 7/27 species (see all 27) About this table
ENSEMBL Gene Tree for ARL5A (if available)
TreeFam Gene Tree for ARL5A (if available) |
Paralogs
for ARL5A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ARL5A gene
- ARL5B2 ARL162 ARL5C2 ARL62 ARL12
18/27 SIMAP similar genes for ARL5A using alignment to 2 protein entries: ARL5A_HUMAN (see all proteins)
(see all similar genes):ARL5B ARL5C ARF1 ARL14 ARF6 ARF3
ARL1 ARF4 ARF5 ARL11 ARL3 ARL10
ARL4A ARFRP1 ARL17A ARL17B ARL6 ARL4C
ARL5A for paralogs About GeneDecksing
5 Pseudogenes.org Pseudogenes for ARL5A
PGOHUM00000238605 PGOHUM00000244062 PGOHUM00000246542 PGOHUM00000241514 PGOHUM00000241862
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Genomic Variants
for ARL5A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ARL5A (152645498 - 152685009 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for ARL5A
3 CNVs: 90079 8961 58924 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARL5A |
|
Disorders
/ Diseases
for ARL5A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ARL5A for disorders About GeneDecksing
OMIM gene information: 608960
OMIM disorders: --
5  diseases for ARL5A: About MalaCardsprostate carcinoma in situ prostate carcinoma liver cancer prostatitis
carcinoma
1 disease from the University of Copenhagen DISEASES database for ARL5A:Prostate carcinoma in situ Export disorders for ARL5A gene to outside databases
|
Publications
for ARL5A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARL5A gene integrated from 9 sources:
(articles sorted by number of sources associating them with ARL5A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- 2.0 A crystal structure of human ARL5-GDP3'P, a novel member of the small GTP-binding proteins. (PubMed id 15896705)1, 2 Wang Z.-X.... Liang D.-C. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification and characterization of nine novel human small GTPases showing variable expressions in liver cancer tissues. (PubMed id 12450215)1, 2 He H.... Zhao S.Y. (2002)
- Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
- A developmentally regulated ARF-like 5 protein (ARL5), localized to nuclei and nucleoli, interacts with heterochromatin protein 1. (PubMed id 12414990)1, 9 Lin C.Y....Lee F.J. (2002)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ARL5A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ARL5A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ARL5A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ARL5A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ARL5A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ARL5A gene:
Search GeneIP for patents involving ARL5A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ARL5A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ARL5A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARL5A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARL5A | | | OriGene Protein Over-expression Lysate for ARL5A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ARL5A | | OriGene 3'-UTR Clone for ARL5A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARL5A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARL5A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ARL5A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARL5A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARL5A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL5A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARL5A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARL5A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARL5A |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL5A |
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