ARL4D Gene
protein-coding GIFtS : 51
GCID: GC17 P041476
ADP-ribosylation factor-like 4D (Previous name: ADP-ribosylation factor 4-like ) (Previous symbol: ARF4L )
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Aliasesfor ARL4D gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases ADP-Ribosylation Factor-Like 4D 1 2 ARL62 ARF4L1 2 3 5 ADP-Ribosylation Factor-Like 62 ADP-Ribosylation Factor-Like Protein 4L2 3 ADP-Ribosylation Factor-Like Protein 4D2 ADP-Ribosylation Factor 4-Like1
Export aliases for ARL4D gene to outside databases Previous GC identifers: GC17P038832 GC17P037238
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Summariesfor ARL4D gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ARL4D : ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4D is closely similar to ARL4A and ARL4C and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in membrane-associated intracellular trafficking. Mutations in this gene have been associated with Bardet-Biedl syndrome (BBS). (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: ARL4D_HUMAN, P49703 Function : Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and therate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form Gene Wiki entry for ARL4D
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Genomic Viewsfor ARL4D gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000017.10 NC_018928.1 NT_010783.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ARL4D gene promoter: USF1 AML1a Pax-5 ATF-2 NF-kappaB Nkx5-1 FOXJ2 (long isoform) USF-1 c-Jun NF-kappaB1 Other transcription factors Search SABiosciences Chromatin IP Primers for ARL4D Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ARL4D
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 17q21.31 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21.31 ARL4D Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17P041476: view genomic region
(about GC identifiers )
Start:
41,476,327 bp from pter
End:
41,478,504 bp from pter
Size:
2,178 bases
Orientation:
plus strand
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Proteinsfor ARL4D gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ARL4D_HUMAN, P49703 (See
protein sequence )Recommended Name: ADP-ribosylation factor-like protein 4D Size : 201 amino acids; 22156 Da
Subunit : Interacts with CYTH2; the interaction is direct and ARL4D GTP-dependent. Does not interact with ARL4D
Subcellular location : Nucleus, nucleolus (By similarity). Cell membrane. Nucleus. Cytoplasm
Secondary accessions : B2RC59 D3DX43Explore the universe of human proteins at neXtProt for ARL4D: NX_P49703 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P49703 ARL4D Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_001652.2 ENSEMBL proteins: ENSP00000322628 Human Recombinant Protein Products: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
ARL4D for ontologies About GeneDecksing ARL4D Antibody Products: Assay Products for ARL4D:
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Protein
Domains / Familiesfor ARL4D gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ARL4D for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P49703 ProtoNet protein and cluster: P49703
2 Blocks protein families : IPB001806 Transforming protein P21 RAS signature IPB006688 ADP-ribosylation factor UniProtKB/Swiss-Prot: ARL4D_HUMAN, P49703 Similarity : Belongs to the small GTPase superfamily. Arf family
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Functionfor ARL4D gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ARL4D_HUMAN, P49703 Function : Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and therate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ARL4D (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ARL4DOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ARL4D (NM_001661 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARL4D Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ARL4D
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL4D
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
ARL4D for ontologies About GeneDecksing Animal Models: 6 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Arl4d) :
ARL4D for phenotypes About GeneDecksing
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Pathways & Interactionsfor ARL4D gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARL4D STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)5/39 Interacting proteins for ARL4D (P49703 2 , 3 ENSP00000322628 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 39 )About this table Gene Ontology (GO): 3 biological process terms (GO ID links to tree view) : About this table
ARL4D for ontologies About GeneDecksing
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Drugs & Compoundsfor ARL4D gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for ARL4D Search CenterWatch for drugs/clinical trials and news about ARL4D
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Transcriptsfor ARL4D gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ARL4D gene: NM_001661.3 Unigene Cluster for ARL4D:
ADP-ribosylation factor-like 4D Hs.183153 [show with all ESTs ] Unigene Representative Sequence: NM_001661 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000320033 (uc002idt.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ARL4D (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ARL4DOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ARL4D (NM_001661 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARL4D Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ARL4D
Additional cDNA sequence: AB060692.1 AK314951.1 BC000043.2 L38490.1
8 DOTS entries : DT.454552 DT.100858256
DT.91697259 DT.121004471 DT.70100473 DT.95378306 DT.100646816 DT.121004472 24/255 AceView cDNA sequences (see all 255 ):
BU161968 AB060692 CR594484 BU634103 BM851892 BQ637194 BX954349 CB240699 CA413969 AA954565 CA390191 AA558481 BQ232628 CR599185 BF109597 AA588192 BE255225 CF528695 BU192649 BX101486 AU099266 BQ720144 BI823575 NM_001661 GeneLoc Exon Structure
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Expression for ARL4D gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ARL4D expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ACCCTTTTTA
About this image ARL4D expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See ARL4D Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ARL4D SOURCE GeneReport for Unigene cluster: Hs.183153 SABiosciences Custom PCR Arrays for ARL4D Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ARL4DBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat ARL4D QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ARL4D QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ARL4D In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL4D
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Orthologsfor ARL4D gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for ARL4D gene from 3/15 species (see all 15 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
lizard (Anolis carolinensis)
Reptilia
ARL4D6
--
77(a)
1 ↔ 1
6(62927852-62928445)
zebrafish (Danio rerio)
Actinopterygii
wufc03d052
wufc03d05
76.01(n)
 
323573 BC062847.1
fruit fly (Drosophila melanogaster)
Insecta
CG22196
--
35(a)
1 → many
4(198064-200015)
ENSEMBL Gene Tree for ARL4D (if available)TreeFam Gene Tree for ARL4D (if available)
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Paralogsfor ARL4D gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ARL4D gene ARL4A 2 ARL11 2 ARF4 2 ARF5 2 ARF1 2 ARL14 2 ARF3 2 ARF6 2 ARL9 2 ARL17B 2 ARL4C 2 TRIM23 2 ARL10 2 18/28 SIMAP similar genes for ARL4D using alignment to 1 protein entry: ARL4D_HUMAN (see all similar genes ):ARL4A ARL4C ARL7 ARF3 ARF5 ARF1 TRIM23 ARL14 ARF4 ARL8A ARF6 ARL10 ARL3 ARL8B ARL5B ARL11 ARL5A ARL6
ARL4D for paralogs About GeneDecksing
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Genomic Variantsfor ARL4D gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 17 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ARL4D (41476327 - 41478504 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ARL4D: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ARL4D
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Disorders
/ Diseasesfor ARL4D gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ARL4D for disorders About GeneDecksing
OMIM gene information: 600732
OMIM disorders : --5 diseases for ARL4D : About MalaCards bardet-biedl syndrome breast-ovarian cancer ovarian cancer cholera malaria Export disorders for ARL4D gene to outside databases
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Publicationsfor ARL4D gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ARL4D gene, integrated from 9 sources (see all 23 ): (articles sorted by number of sources associating them with ARL4D) Utopia : connect your pdf to the dynamic world of online information
Isolation and mapping of a gene encoding a novel human ADP- ribosylation factor on chromosome 17q12-q21. (PubMed id 7590735) 1 , 2 , 3 Smith S.A.... Albertsen H. (1995) The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. (PubMed id 17398095) 1 , 2 Hofmann I....Munro S. (2007) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Comparison of the positional cloning methods used to isolate the BRCA1 gene. (PubMed id 7581362) 1 , 2 Harshman K.... Kamb A. (1995) Recognition of ADP-ribosylation factor 4-like by HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes from patients with brain tumors. (PubMed id 12472661) 1 , 9 Nonaka Y....Itoh K. (2002) GTP-binding-defective ARL4D alters mitochondrial morph ology and membrane potential. (PubMed id 22927989) 1 Li C.C....Lee F.J. (2012) A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473) 1 Wagner S.A....Choudhary C. (2011) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070) 1 Stelzl U.... Wanker E.E. (2005)
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External Searches for ARL4D gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ARL4D gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ARL4D gene
(According to HUGE )
About This Section --
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Specialized Databases showing ARL4D gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ARL4D Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ARL4D gene: Search GeneIP for patents involving ARL4D GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ARL4D gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for ARL4D OriGene shRNA RFP for ARL4D OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ARL4D OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ARL4D OriGene Protein Over-expression Lysate for ARL4D Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ARL4D OriGene 3'-UTR Clone for ARL4D OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ARL4D OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ARL4D Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ARL4D OriGene Custom Protein Services for ARL4D OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARL4D QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ARL4D QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ARL4D QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ARL4D QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ARL4D QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ARL4D
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Recombinant Protein for ARL4D
ARL4D Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL4D
ThermoFisher Antibodies for ARL4D
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ARL4D
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