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Aliases for ARL4D Gene

Aliases for ARL4D Gene

  • ADP Ribosylation Factor Like GTPase 4D 2 3 5
  • ADP-Ribosylation Factor-Like Protein 4L 3 4
  • ADP-Ribosylation Factor-Like 4D 2 3
  • ARF4L 3 4
  • ADP-Ribosylation Factor-Like Protein 4D 3
  • ADP-Ribosylation Factor 4-Like 2
  • ADP-Ribosylation Factor-Like 6 3
  • ARL6 3

External Ids for ARL4D Gene

Previous HGNC Symbols for ARL4D Gene

  • ARF4L

Previous GeneCards Identifiers for ARL4D Gene

  • GC17P038832
  • GC17P041476
  • GC17P037238

Summaries for ARL4D Gene

Entrez Gene Summary for ARL4D Gene

  • ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4D is closely similar to ARL4A and ARL4C and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in membrane-associated intracellular trafficking. Mutations in this gene have been associated with Bardet-Biedl syndrome (BBS). [provided by RefSeq, Jul 2008]

GeneCards Summary for ARL4D Gene

ARL4D (ADP Ribosylation Factor Like GTPase 4D) is a Protein Coding gene. Diseases associated with ARL4D include Bardet-Biedl Syndrome. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is ARL4A.

UniProtKB/Swiss-Prot for ARL4D Gene

  • Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.

Gene Wiki entry for ARL4D Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL4D Gene

Genomics for ARL4D Gene

Regulatory Elements for ARL4D Gene

Enhancers for ARL4D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G043455 1.6 Ensembl ENCODE dbSUPER 11.5 +58.4 58435 4.4 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF207 DHX8 ETV4 MIR2117HG RNU6-470P ARL4D RNU6-1137P LINC00910 RNU2-4P MEOX1 GC17P043466
GH17G043448 1 dbSUPER 10.7 +50.6 50591 1.8 PKNOX1 FOXA2 MLX SIN3A ARID4B YY1 SP3 SP5 MXD4 KAT8 DHX8 RETREG3 ASB16-AS1 HMGN1P29 NBR2 ARL4D PSME3 VPS25 ETV4 CNTNAP1
GH17G043428 0.9 dbSUPER 11.6 +30.6 30556 1.2 FOXA2 PKNOX1 ZFP64 FOS ZNF280D CEBPB ELF4 JUNB ELF1 ZNF592 MIR2117HG ARL4D RNU6-1137P DHX8 MEOX1 LINC00910 GC17M043406 GC17P043413
GH17G043562 1 VISTA ENCODE 10.2 +164.2 164198 0.8 DRAP1 ZNF792 FEZF1 ZIC2 ZNF335 ZSCAN5C ZNF600 TCF7L2 ZBTB20 ZNF263 DHX8 MEOX1 RNU6-1137P SOST ARL4D RNU6-406P MIR2117 RAMP2 ENSG00000267747 ETV4
GH17G043465 0.9 ENCODE 11 +67.3 67282 0.9 MLX ARID4B DMAP1 ZNF48 YY1 ZNF121 SLC30A9 SP5 MXD4 MIER2 RNU6-1137P ARL4D RNU6-406P MIR2117 MIR2117HG ETV4 GC17P043466 GC17P043475
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARL4D on UCSC Golden Path with GeneCards custom track

Promoters for ARL4D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000283465 241 1201 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF263 SP3 SP5
ENSR00000094565 1741 201 KLF4

Genomic Location for ARL4D Gene

Chromosome:
17
Start:
43,398,959 bp from pter
End:
43,401,137 bp from pter
Size:
2,179 bases
Orientation:
Plus strand

Genomic View for ARL4D Gene

Genes around ARL4D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL4D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL4D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL4D Gene

Proteins for ARL4D Gene

  • Protein details for ARL4D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49703-ARL4D_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 4D
    Protein Accession:
    P49703
    Secondary Accessions:
    • B2RC59
    • D3DX43

    Protein attributes for ARL4D Gene

    Size:
    201 amino acids
    Molecular mass:
    22156 Da
    Quaternary structure:
    • Interacts with CYTH2; the interaction is direct and ARL4D GTP-dependent. Does not interact with ARL4D.

neXtProt entry for ARL4D Gene

Post-translational modifications for ARL4D Gene

  • Ubiquitination at Lys44
  • Modification sites at PhosphoSitePlus

Other Protein References for ARL4D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARL4D Gene

Domains & Families for ARL4D Gene

Gene Families for ARL4D Gene

Suggested Antigen Peptide Sequences for ARL4D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49703

UniProtKB/Swiss-Prot:

ARL4D_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL4D: view

Function for ARL4D Gene

Molecular function for ARL4D Gene

UniProtKB/Swiss-Prot Function:
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.

Gene Ontology (GO) - Molecular Function for ARL4D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 7590735
GO:0005515 protein binding IPI 17398095
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with ARL4D: view
genes like me logo Genes that share phenotypes with ARL4D: view

Animal Models for ARL4D Gene

MGI Knock Outs for ARL4D:

Animal Model Products

  • Taconic Biosciences Mouse Models for ARL4D

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ARL4D

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARL4D Gene

Localization for ARL4D Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL4D Gene

Nucleus, nucleolus. Cell membrane. Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL4D gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 3

Gene Ontology (GO) - Cellular Components for ARL4D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IDA,IEA 17398095
GO:0005886 plasma membrane IEA,IDA 17398095
genes like me logo Genes that share ontologies with ARL4D: view

Pathways & Interactions for ARL4D Gene

SuperPathways for ARL4D Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL4D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0009306 protein secretion TAS 7590735
genes like me logo Genes that share ontologies with ARL4D: view

No data available for Pathways by source and SIGNOR curated interactions for ARL4D Gene

Transcripts for ARL4D Gene

mRNA/cDNA for ARL4D Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(255) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARL4D Gene

ADP-ribosylation factor-like 4D:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ARL4D

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL4D Gene

No ASD Table

Relevant External Links for ARL4D Gene

GeneLoc Exon Structure for
ARL4D
ECgene alternative splicing isoforms for
ARL4D

Expression for ARL4D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARL4D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARL4D Gene

This gene is overexpressed in Esophagus - Mucosa (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of ARL4D Gene:

ARL4D

SOURCE GeneReport for Unigene cluster for ARL4D Gene:

Hs.183153

Evidence on tissue expression from TISSUES for ARL4D Gene

  • Eye(4.7)
  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with ARL4D: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL4D Gene

Orthologs for ARL4D Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARL4D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARL4D 34 35
  • 99.67 (n)
dog
(Canis familiaris)
Mammalia ARL4D 34 35
  • 91.21 (n)
oppossum
(Monodelphis domestica)
Mammalia ARL4D 35
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARL4D 34 35
  • 89.83 (n)
mouse
(Mus musculus)
Mammalia Arl4d 34 16 35
  • 86.24 (n)
rat
(Rattus norvegicus)
Mammalia Arl4d 34
  • 86.24 (n)
lizard
(Anolis carolinensis)
Reptilia ARL4D 35
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii arl4d 34 35
  • 69.33 (n)
wufc03d05 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1686 34
fruit fly
(Drosophila melanogaster)
Insecta CG2219 35
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARF3 35
  • 38 (a)
OneToMany
Species where no ortholog for ARL4D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARL4D Gene

ENSEMBL:
Gene Tree for ARL4D (if available)
TreeFam:
Gene Tree for ARL4D (if available)

Paralogs for ARL4D Gene

Paralogs for ARL4D Gene

(28) SIMAP similar genes for ARL4D Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARL4D: view

Variants for ARL4D Gene

Sequence variations from dbSNP and Humsavar for ARL4D Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1001571192 -- 43,397,145(+) CTGTA(C/T)TAAAA upstream-variant-2KB
rs1002576957 -- 43,400,217(+) CACTC(C/T)CACTC reference, missense
rs1003500315 -- 43,398,278(+) GCACC(A/C)GCCAC upstream-variant-2KB
rs1003582316 -- 43,398,959(+) CACGC(A/G)GGTTT upstream-variant-2KB
rs1004125418 -- 43,397,890(+) CAACC(C/T)CCGCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ARL4D Gene

Variant ID Type Subtype PubMed ID
esv2761959 CNV gain 21179565
esv3640625 CNV gain 21293372
nsv1060861 CNV gain 25217958
nsv1065802 CNV gain 25217958
nsv1146669 OTHER inversion 26484159
nsv470588 CNV gain 18288195
nsv833451 CNV loss 17160897
nsv833452 CNV loss 17160897

Variation tolerance for ARL4D Gene

Residual Variation Intolerance Score: 32.5% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARL4D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARL4D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL4D Gene

Disorders for ARL4D Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARL4D Gene - From: GeneCards

Disorder Aliases PubMed IDs
bardet-biedl syndrome
  • biedl-bardet syndrome
- elite association - COSMIC cancer census association via MalaCards
Search ARL4D in MalaCards View complete list of genes associated with diseases

Relevant External Links for ARL4D

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARL4D
genes like me logo Genes that share disorders with ARL4D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARL4D Gene

Publications for ARL4D Gene

  1. Isolation and mapping of a gene encoding a novel human ADP- ribosylation factor on chromosome 17q12-q21. (PMID: 7590735) Smith S.A. … Albertsen H. (Genomics 1995) 2 3 4 64
  2. GTP-binding-defective ARL4D alters mitochondrial morphology and membrane potential. (PMID: 22927989) Li C.C. … Lee F.J. (PLoS ONE 2012) 2 3 64
  3. The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. (PMID: 17398095) Hofmann I. … Munro S. (Curr. Biol. 2007) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Recognition of ADP-ribosylation factor 4-like by HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes from patients with brain tumors. (PMID: 12472661) Nonaka Y. … Itoh K. (Tissue Antigens 2002) 3 22 64

Products for ARL4D Gene

Sources for ARL4D Gene

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