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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARL4C Gene

protein-coding   GIFtS: 52
GCID: GC02M235401

ADP-ribosylation factor-like 4C

(Previous name: ADP-ribosylation factor-like 7 )
(Previous symbol: ARL7)
 Explore 6 diseases affiliated with
ARL4C via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ARL4C    

Aliases
for ARL4C gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
ADP-Ribosylation Factor-Like 4C1 2     ADP-Ribosylation Factor-Like Protein 72 3
ARL71 2 3     ADP-Ribosylation Factor-Like Protein LAK2 3
LAK1 2     ADP Ribosylation Factor-Like Protein 72
ADP-Ribosylation Factor-Like 71 2     ADP-Ribosylation Factor-Like Protein 4C2

External Ids:    HGNC: 6981   Entrez Gene: 101232   Ensembl: ENSG000001880427   OMIM: 6047875   UniProtKB: P565593   
ORGUL members:         
NONCODE:n339176    

Export aliases for ARL4C gene to outside databases

Previous GC identifers: GC02M235184 GC02M235066 GC02M227201


Summaries
for ARL4C gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ARL4C:
ADP-ribosylation factor-like 4C is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4C is
closely similar to ARL4A and ARL4D and each has a nuclear localization signal and an unusually high guanine nucleotide
exchange rate. This protein may play a role in cholesterol transport. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ARL4C_HUMAN, P56559
Function: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the
rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP).
GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be
involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the
ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the
GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling
endosome process




Genomic Views
for ARL4C gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005120.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARL4C gene promoter:
         Nkx3-1   HOXA9B   HOXA9   Nkx3-1 v1   POU6F1 (c2)   Meis-1b   c-Ets-1   HSF2   ATF   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ARL4C promoter sequence
   Search SABiosciences Chromatin IP Primers for ARL4C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL4C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.2

ARL4C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL4C gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M235401:  view genomic region     (about GC identifiers)

Start:
 235,401,685 bp from pter      End:
 235,405,697 bp from pter
Size:
 4,013 bases      Orientation:
 minus strand

Proteins
for ARL4C gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ARL4C_HUMAN, P56559 (See protein sequence)
Recommended Name: ADP-ribosylation factor-like protein 4C  
Size: 192 amino acids; 21487 Da
Subunit: Interacts with CYTH2. Interacts with alpha tubulin; interaction is independent on the ARL4C GTP or GDP binding
status
Subcellular location: Cell projection, filopodium. Cell membrane. Cytoplasm
Sequence caution: Sequence=BAA75473.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q53R10 Q9BVN1 Q9UQ34

Explore the universe of human proteins at neXtProt for ARL4C: NX_P56559

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P56559

    • ARL4C Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005728.2  
    ENSEMBL proteins: 
     ENSP00000375057   ENSP00000339754  

    Human Recombinant Protein Products: 
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    Novus Biologicals ARL4C Protein
    Novus Biologicals ARL4C Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ARL4C

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10462049
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--
    GO:0030175filopodium IEA--


    ARL4C for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ARL4C gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ARL4C for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF
     IPR005225 Small_GTP-bd_dom

    Graphical View of Domain Structure for InterPro Entry P56559

    ProtoNet protein and cluster: P56559

    2 Blocks protein families:
    IPB001806 Transforming protein P21 RAS signature
    IPB006688 ADP-ribosylation factor


    UniProtKB/Swiss-Prot: ARL4C_HUMAN, P56559
    Similarity: Belongs to the small GTPase superfamily. Arf family


    Function
    for ARL4C gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ARL4C_HUMAN, P56559
    Function: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the
    rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP).
    GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be
    involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the
    ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the
    GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling
    endosome process
    Induction: By liver X-receptor/retinoid X receptor agonists or cholesterol loading

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARL4C
    8/101 QIAGEN miScript miRNA Assays for microRNAs that regulate ARL4C (see all 101):
    hsa-miR-579 hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-219-5p hsa-miR-3653 hsa-miR-30d hsa-miR-4315
    SwitchGear 3'UTR luciferase reporter plasmid: ARL4C 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARL4C (see all 4)
    OriGene shRNA RFP: ARL4C
    OriGene siRNA: ARL4C
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ARL4C

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARL4C (see all 2)
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    Cell Line
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    Search LifeMap BioReagents cell lines for ARL4C

    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS10462049
    GO:0005515protein binding IPI17398095
    GO:0005525GTP binding IEA--
    GO:0043014alpha-tubulin binding IDA19409876


    ARL4C for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ARL4C:
     Decreased POU5F1-GFP protein e  Decreased substrate adherent c 


    Pathways & Interactions
    for ARL4C gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARL4C

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ARL4C (P565592, 3 ENSP000003750574) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2867972 I2D: score=2 STRING: ENSP00000357292
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS10462049
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0032456endocytic recycling IDA19409876


    ARL4C for ontologies           About GeneDecksing



    Drugs & Compounds
    for ARL4C gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARL4C

    1 HMDB Compound for ARL4C    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Search CenterWatch for drugs/clinical trials and news about ARL4C 

    Transcripts
    for ARL4C gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ARL4C gene: 
    NM_005737.3  

    Unigene Clusters for ARL4C:

    ADP-ribosylation factor-like 4C
    Hs.111554  [show with all ESTs], Hs.730678  [show with all ESTs]
    Unigene Representative Sequences: AJ579850, NM_005737
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000390645(uc002vvn.3) ENST00000339728(uc002vvm.4)

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARL4C
    8/101 QIAGEN miScript miRNA Assays for microRNAs that regulate ARL4C (see all 101):
    hsa-miR-579 hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-219-5p hsa-miR-3653 hsa-miR-30d hsa-miR-4315
    SwitchGear 3'UTR luciferase reporter plasmid: ARL4C 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARL4C (see all 4)
    OriGene shRNA RFP: ARL4C
    OriGene siRNA: ARL4C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARL4C
    Clone
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    GenScript: all cDNA clones in your preferred vector: ARL4C (NM_005737)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARL4C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL4C 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARL4C
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARL4C

    Additional cDNA sequence: 

    AB016811.1 AF493892.1 AJ579851.1 AK314119.1 BC001051.2 BC089043.1 BT019378.1 BT019379.1 
    Y17804.1 

    6 DOTS entries:

    DT.449758  DT.97847337  DT.91745110  DT.97861457  DT.95101408  DT.100661299 

    24/333 AceView cDNA sequences (see all 333):

    AI524191 BF939959 W73356 CA441253 BM712863 AW079738 CA427195 AI097247 
    F09688 BM973816 AI096988 CB158690 BQ022453 BM931990 BX382329 BM726963 
    AI190178 BI496244 CA335601 AI868184 AA349786 BQ015167 BQ233326 BF514587 

    GeneLoc Exon Structure


    Expression
    for ARL4C gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARL4C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTAGGTCAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ARL4C expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 9 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ARL4C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARL4C

    SOURCE GeneReport for Unigene clusters: Hs.111554 Hs.730678

    UniProtKB/Swiss-Prot: ARL4C_HUMAN, P56559
    Tissue specificity: Expressed in several tumor cell lines (at protein level). Expressed in lung, brain, leukocytes and
    placenta

        SABiosciences Custom PCR Arrays for ARL4C
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL4C

    Orthologs
    for ARL4C gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ARL4C gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ARL4C1 ADP-ribosylation factor-like 4C 93.4(n)
    97.92(a)    		   424026  XM_001237034.2  XP_001237035.2 
    lizard
    (Anolis carolinensis)    		 Reptilia ARL4C6
    		 --
    		 98(a)
    		 1 ↔ 1
    		 1(119149092-119149670)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.177652 Transcribed sequence with moderate similarity to protein more 82.26(n)    141993947 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufc01g112 Danio rerio cDNA clone MGC77633 IMAGE6996875, complete more 78.63(n)    BC062829.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG22196
    		 --
    		 35(a)
    		 1 → many
    		 4(198064-200015)


    ENSEMBL Gene Tree for ARL4C (if available)
    TreeFam Gene Tree for ARL4C (if available) 

    Paralogs
    for ARL4C gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARL4C gene
    ARL4A2  ARL112  ARF42  ARF52  ARF12  ARL4D2  ARL142  ARF32  
    ARF62  ARL92  ARL17B2  TRIM232  ARL102  
    18/27 SIMAP similar genes for ARL4C using alignment to 1 protein entry:     ARL4C_HUMAN(see all similar genes):
    ARL7    ARL4A    ARL4D    ARF5    ARL14    ARF6
    ARF1    ARL2    ARF4    TRIM23    ARF3    ARL11
    ARL3    ARL10    SAR1A    SAR1B    ARL5A    ARL1

    ARL4C for paralogs           About GeneDecksing



    Genomic Variants
    for ARL4C gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/107 NCBI SNPs in ARL4C are shown (see all 107)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1158968281,2
    		C,F,--235401221(+) GGACTC/TAGCCC 1 -- ds50011Minor allele frequency- T:0.05NA 120
    rs1811369681,2
    		--235401229(+) CCCAGA/GTACTG 1 -- ds50010--------
    rs31153591,2
    		C,F,A,H,--235401375(-) TCCTCA/GGCACT 1 -- ds500128Minor allele frequency- N:0.00EA NA NS WA CSA 2965
    rs1848581931,2
    		--235401424(+) AATGAC/TGCAGT 1 -- ds50010--------
    rs1436081401,2
    		--235401514(+) CCACCA/GTTCAC 1 -- ds50010--------
    rs1142091671,2
    		F,--235401562(+) TGATAT/CACCGA 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs762755521,2
    		F,--235401563(+) GATATA/GCCGAC 1 -- ds50011Minor allele frequency- G:0.05WA 118
    rs1901459231,2
    		--235401564(+) ATATAA/CCGACT 1 -- ds50010--------
    rs1818575511,2
    		--235401641(+) CAATGC/TCAAAA 1 -- ds50010--------
    rs113864011,2
    		C,--235401642(+) ATGTCA/-AAAAA 1 -- ds50011Minor allele frequency- -:0.00CSA 2

    HapMap Linkage Disequilibrium report for ARL4C (235401685 - 235405697 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ARL4C: --

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    Disorders / Diseases
    for ARL4C gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ARL4C for disorders           About GeneDecksing

    OMIM gene information: 604787    OMIM disorders: --

    6 diseases for ARL4C:    About MalaCards
    cholesterol    cholera    pancreatic cancer    pancreatitis
    ataxia    malaria


    Export disorders for ARL4C gene to outside databases

    Publications
    for ARL4C gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARL4C gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with ARL4C)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. ADP-ribosylation factor like 7 (ARL7) interacts with alpha-tubulin and modulates intracellular vesicular transport. (PubMed id 19409876)1, 2, 9 Wei S.M....Cai J.T. (2009)
    2. The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. (PubMed id 17398095)1, 2 Hofmann I....Munro S. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. ADP-ribosylation factor (ARF)-like 7 (ARL7) is induced by cholesterol loading and participates in apolipoprotein AI-dependent cholesterol export. (PubMed id 15147902)1, 2 Engel T....Seedorf U. (2004)
    5. ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal. (PubMed id 10462049)1, 2 Jacobs S....Joost H.-G. (1999)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Constitutive activation of LXR in macrophages regulat es metabolic and inflammatory gene expression: identification of ARL7 as a dire ct target. (PubMed id 21187453)1 Hong C....Tontonoz P. (2011)
    8. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    9. Genome-wide association study of pancreatic cancer in Japanese population. (PubMed id 20686608)1 Low S.K....Sakamoto H. (2010)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

    External Searches for ARL4C gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing ARL4C gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10123 HGNC: 698 AceView: ARL7 Ensembl:ENSG00000188042 euGenes: HUgn10123
    ECgene: ARL4C H-InvDB: ARL4C

    Other Databases showing ARL4C gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ARL4C gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARL4C Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ARL4C gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ARL4C gene:
    Search GeneIP for patents involving ARL4C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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