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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARL4C Gene

protein-coding   GIFtS: 52
GCID: GC02M235401

ADP-Ribosylation Factor-Like 4C

(Previous name: ADP-ribosylation factor-like 7)
(Previous symbol: ARL7)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
ADP-Ribosylation Factor-Like 4C1 2     ADP-Ribosylation Factor-Like Protein LAK2 3
ARL71 2 3     LAK2
ADP-Ribosylation Factor-Like 71 2     ADP Ribosylation Factor-Like Protein 72
ADP-Ribosylation Factor-Like Protein 72 3     ADP-Ribosylation Factor-Like Protein 4C2

External Ids:    HGNC: 6981   Entrez Gene: 101232   Ensembl: ENSG000001880427   OMIM: 6047875   UniProtKB: P565593   
ORGUL members:         
NONCODE14:n339176      

Export aliases for ARL4C gene to outside databases

Previous GC identifers: GC02M235184 GC02M235066 GC02M227201


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARL4C Gene:
ADP-ribosylation factor-like 4C is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4C
is closely similar to ARL4A and ARL4D and each has a nuclear localization signal and an unusually high guanine
nucleotide exchange rate. This protein may play a role in cholesterol transport. (provided by RefSeq, Jul 2008)

GeneCards Summary for ARL4C Gene: 
ARL4C (ADP-ribosylation factor-like 4C) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with ARL4C include cholera, and pancreatic cancer. GO annotations related to this gene include alpha-tubulin binding and GTP binding. An important paralog of this gene is ARL4A.

UniProtKB/Swiss-Prot: ARL4C_HUMAN, P56559
Function: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and
the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins
(GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit.
May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the
ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in
the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to
recycling endosome process




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005120.16  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARL4C gene promoter:
         Nkx3-1   HOXA9B   HOXA9   Nkx3-1 v1   POU6F1 (c2)   Meis-1b   c-Ets-1   HSF2   ATF   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARL4C promoter sequence
   Search SABiosciences Chromatin IP Primers for ARL4C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL4C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.2

ARL4C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL4C gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M235401:  view genomic region     (about GC identifiers)

Start:
235,401,685 bp from pter      End:
235,405,697 bp from pter
Size:
4,013 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARL4C_HUMAN, P56559 (See protein sequence)
Recommended Name: ADP-ribosylation factor-like protein 4C  
Size: 192 amino acids; 21487 Da
Subunit: Interacts with CYTH2. Interacts with alpha tubulin; interaction is independent on the ARL4C GTP or GDP
binding status
Subcellular location: Cell projection, filopodium. Cell membrane. Cytoplasm
Sequence caution: Sequence=BAA75473.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q53R10 Q9BVN1 Q9UQ34

Explore the universe of human proteins at neXtProt for ARL4C: NX_P56559

Explore proteomics data for ARL4C at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P56559

  • ARL4C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARL4C Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001269360.1  NP_005728.2  

    ENSEMBL proteins: 
     ENSP00000375057   ENSP00000339754  

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    Cloud-Clone Corp. Proteins for ARL4C 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus TAS10462049
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--
    GO:0030175filopodium IEA--

    ARL4C for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ARL: ADP-ribosylation factors-like

    4 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF
     IPR005225 Small_GTP-bd_dom

    Graphical View of Domain Structure for InterPro Entry P56559

    ProtoNet protein and cluster: P56559

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB006688 ADP-ribosylation factor


    UniProtKB/Swiss-Prot: ARL4C_HUMAN, P56559
    Similarity: Belongs to the small GTPase superfamily. Arf family


    ARL4C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARL4C_HUMAN, P56559
    Function: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and
    the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins
    (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit.
    May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the
    ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in
    the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to
    recycling endosome process
    Induction: By liver X-receptor/retinoid X receptor agonists or cholesterol loading

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS10462049
    GO:0005515protein binding IPI17398095
    GO:0005525GTP binding IEA--
    GO:0043014alpha-tubulin binding IDA19409876
         
    ARL4C for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARL4C:
     Decreased POU5F1-GFP protein e  Decreased substrate adherent c 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ARL4C 
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    SwitchGear 3'UTR luciferase reporter plasmidARL4C 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARL4C

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ARL4C (P565592, 3 ENSP000003750574) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2867972 I2D: score=2 STRING: ENSP00000357292
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS10462049
    GO:0006886intracellular protein transport ----
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport ----
    GO:0032456endocytic recycling IDA19409876

    ARL4C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ARL4C

    1 HMDB Compound for ARL4C    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about ARL4C

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARL4C gene (2 alternative transcripts): 
    NM_001282431.1  NM_005737.3  

    Unigene Clusters for ARL4C:

    ADP-ribosylation factor-like 4C
    Hs.111554  [show with all ESTs], Hs.730678  [show with all ESTs]
    Unigene Representative Sequences: AJ579850, NM_005737
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000390645(uc002vvn.3) ENST00000339728(uc002vvm.4)
    miRNA
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    hsa-miR-579 hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-219-5p hsa-miR-3653 hsa-miR-30d hsa-miR-4315
    SwitchGear 3'UTR luciferase reporter plasmidARL4C 3' UTR sequence
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    Additional mRNA sequence: 

    AB016811.1 AF493892.1 AJ579851.1 AK314119.1 BC001051.2 BC089043.1 BT019378.1 BT019379.1 
    Y17804.1 

    6 DOTS entries:

    DT.449758  DT.97847337  DT.91745110  DT.97861457  DT.95101408  DT.100661299 

    24/333 AceView cDNA sequences (see all 333):

    AA349786 AW450363 BU738893 BQ020748 BM918203 AA722270 BM717241 AI147612 
    CA335601 AA843717 BQ015108 AI821520 BI496244 BF434134 BM876208 CB140646 
    BM973816 BQ015167 BM931990 F09688 AI190178 AI089967 AA283614 CA442858 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARL4C expression in normal human tissues (normalized intensities)      ARL4C embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAGGTCAT
    ARL4C Expression
    About this image


    ARL4C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 25 entries
             Thalamus
             Human Cerebellar Astrocytes   
             Vomeronasal organ   
     
     Uncategorized (Uncategorized)    fully expand to see all 4 entries
             PureStem Progenitor EN7
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Dorsal Horn   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Kidney (Urinary System)
             Human Renal Mesangial Cells (HRMC)   

    See ARL4C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARL4C

    SOURCE GeneReport for Unigene clusters: Hs.111554 Hs.730678

    UniProtKB/Swiss-Prot: ARL4C_HUMAN, P56559
    Tissue specificity: Expressed in several tumor cell lines (at protein level). Expressed in lung, brain, leukocytes
    and placenta

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ARL4C gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arl4c1 , 5 ADP-ribosylation factor-like 4C1, 5 95.49(n)1
    100(a)1
      1 (44.85 cM)5
    3209821  NM_177305.41  NP_796279.21 
     886731255 
    chicken
    (Gallus gallus)
    Aves ARL4C1 ADP-ribosylation factor-like 4C 93.4(n)
    97.92(a)
      424026  XM_001237034.2  XP_001237035.2 
    lizard
    (Anolis carolinensis)
    Reptilia ARL4C6
    Uncharacterized protein
    98(a)
    1 ↔ 1
    1(119149092-119149670)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.177652 Transcribed sequence with moderate similarity to protein more 82.26(n)    141993947 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc01g112 Danio rerio cDNA clone MGC77633 IMAGE6996875, complete more 78.63(n)    BC062829.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG22196
    CG178196
    --
    36(a)
    27(a)
    1 ↔ many
    possible ortholog
    4(198064-200015)
    3R(17710450-17711272)
    worm
    (Caenorhabditis elegans)
    Secernentea arc-16
    E3 ubiquitin-protein ligase arc-1
    11(a)
    possible ortholog
    II(9674975-9677205)


    ENSEMBL Gene Tree for ARL4C (if available)
    TreeFam Gene Tree for ARL4C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARL4C gene
    ARL4A2  ARF42  ARL112  ARF52  ARF12  ARL142  ARL4D2  ARF32  
    ARF62  ARL8A2  TRIM232  ARL8B2  
    18/27 SIMAP similar genes for ARL4C using alignment to 1 protein entry:     ARL4C_HUMAN(see all similar genes):
    ARL7    ARL4A    ARL4D    ARF5    ARL14    ARF6
    ARF1    ARF4    TRIM23    ARF3    ARL11    ARL3
    ARL10    ARL2    SAR1A    SAR1B    ARL5A    ARL1

    ARL4C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/137 SNPs in ARL4C are shown (see all 137)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1158968281,2
    C,F--235401221(+) GGACTC/TAGCCC 1 -- ds50011Minor allele frequency- T:0.05NA 120
    rs1811369681,2
    --235401229(+) CCCAGA/GTACTG 1 -- ds50010--------
    rs31153591,2
    C,F,A,H--235401375(-) TCCTCA/GGCACT 1 -- ds500128Minor allele frequency- N:0.00EA NA NS WA CSA 2965
    rs1848581931,2
    C--235401424(+) AATGAC/TGCAGT 1 -- ds50010--------
    rs1436081401,2
    C--235401514(+) CCACCA/GTTCAC 1 -- ds50010--------
    rs1142091671,2
    C,F--235401562(+) TGATAT/CACCGA 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs762755521,2
    C,F--235401563(+) GATATA/GCCGAC 1 -- ds50011Minor allele frequency- G:0.05WA 118
    rs1901459231,2
    --235401564(+) ATATAA/CCGACT 1 -- ds50010--------
    rs1818575511,2
    --235401641(+) CAATGC/TCAAAA 1 -- ds50010--------
    rs113864011,2
    C--235401642(+) AAAAAA/-CAAAC 1 -- ds50011Minor allele frequency- -:0.00CSA 2

    HapMap Linkage Disequilibrium report for ARL4C (235401685 - 235405697 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ARL4C: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ARL4C
    DNA2.0 Custom Variant and Variant Library Synthesis for ARL4C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604787    OMIM disorders: --

    3 diseases for ARL4C:    About MalaCards
    cholera    pancreatic cancer    pancreatitis


    ARL4C for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARL4C

    Export disorders for ARL4C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARL4C gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with ARL4C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ADP-ribosylation factor like 7 (ARL7) interacts with alpha-tubulin and modulates intracellular vesicular transport. (PubMed id 19409876)1, 2, 9 Wei S.M....Cai J.T. (2009)
    2. Genome-wide association study of pancreatic cancer in Japanese population. (PubMed id 20686608)1, 4 Low S.K....Sakamoto H. (2010)
    3. The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. (PubMed id 17398095)1, 2 Hofmann I....Munro S. (2007)
    4. ADP-ribosylation factor (ARF)-like 7 (ARL7) is induced by cholesterol loading and participates in apolipoprotein AI-dependent cholesterol export. (PubMed id 15147902)1, 2 Engel T....Seedorf U. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal. (PubMed id 10462049)1, 2 Jacobs S....Joost H.-G. (1999)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Constitutive activation of LXR in macrophages regulat es metabolic and inflammatory gene expression: identification of ARL7 as a dire ct target. (PubMed id 21187453)1 Hong C....Tontonoz P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10123 HGNC: 698 AceView: ARL7 Ensembl:ENSG00000188042 euGenes: HUgn10123
    ECgene: ARL4C H-InvDB: ARL4C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARL4C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARL4C gene:
    Search GeneIP for patents involving ARL4C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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