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ARL4C Gene

protein-coding   GIFtS: 53
GCID: GC02M235401

ADP-Ribosylation Factor-Like 4C

(Previous name: ADP-ribosylation factor-like 7)
(Previous symbol: ARL7)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
ADP-Ribosylation Factor-Like 4C1 2     ADP-Ribosylation Factor-Like Protein LAK2 3
ARL71 2 3 5     LAK2
ADP-Ribosylation Factor-Like 71 2     ADP Ribosylation Factor-Like Protein 72
ADP-Ribosylation Factor-Like Protein 72 3     ADP-Ribosylation Factor-Like Protein 4C2

External Ids:    HGNC: 6981   Entrez Gene: 101232   Ensembl: ENSG000001880427   OMIM: 6047875   UniProtKB: P565593   
ORGUL members:         

Export aliases for ARL4C gene to outside databases

Previous GC identifers: GC02M235184 GC02M235066 GC02M227201


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARL4C Gene:
ADP-ribosylation factor-like 4C is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4C
is closely similar to ARL4A and ARL4D and each has a nuclear localization signal and an unusually high guanine
nucleotide exchange rate. This protein may play a role in cholesterol transport. (provided by RefSeq, Jul 2008)

GeneCards Summary for ARL4C Gene:
ARL4C (ADP-ribosylation factor-like 4C) is a protein-coding gene. Diseases associated with ARL4C include cholera, and pancreatic cancer. GO annotations related to this gene include alpha-tubulin binding and GTP binding. An important paralog of this gene is ARL4D.

UniProtKB/Swiss-Prot: ARL4C_HUMAN, P56559
Function: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and
the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins
(GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit.
May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the
ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in
the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to
recycling endosome process




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARL4C gene promoter:
         Nkx3-1   HOXA9B   HOXA9   Nkx3-1 v1   POU6F1 (c2)   Meis-1b   c-Ets-1   HSF2   ATF   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARL4C promoter sequence
   Search Chromatin IP Primers for ARL4C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARL4C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.2

ARL4C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL4C gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M235401:  view genomic region     (about GC identifiers)

Start:
235,401,685 bp from pter      End:
235,405,697 bp from pter
Size:
4,013 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ARL4C_HUMAN, P56559 (See protein sequence)
Recommended Name: ADP-ribosylation factor-like protein 4C  
Size: 192 amino acids; 21487 Da
Subunit: Interacts with CYTH2. Interacts with alpha tubulin; interaction is independent on the ARL4C GTP or GDP
binding status
Sequence caution: Sequence=BAA75473.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q53R10 Q9BVN1 Q9UQ34

Explore the universe of human proteins at neXtProt for ARL4C: NX_P56559

Explore proteomics data for ARL4C at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys181
  • Modification sites at PhosphoSitePlus

  • See ARL4C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001269360.1  NP_005728.2  

    ENSEMBL proteins: 
     ENSP00000375057   ENSP00000339754  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARL: ADP-ribosylation factors-like
    ARF: ADP-ribosylation factors

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR027417 P-loop_NTPase
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF

    Graphical View of Domain Structure for InterPro Entry P56559

    ProtoNet protein and cluster: P56559

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB006688 ADP-ribosylation factor


    UniProtKB/Swiss-Prot: ARL4C_HUMAN, P56559
    Similarity: Belongs to the small GTPase superfamily. Arf family


    ARL4C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARL4C_HUMAN, P56559
    Function: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and
    the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins
    (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit.
    May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the
    ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in
    the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to
    recycling endosome process
    Induction: By liver X-receptor/retinoid X receptor agonists or cholesterol loading

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS10462049
    GO:0005515protein binding IPI17398095
    GO:0005525GTP binding IEA--
    GO:0043014alpha-tubulin binding IDA19409876
         
    ARL4C for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARL4C:
     Decreased POU5F1-GFP protein e  Decreased substrate adherent c 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARL4C
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    miRNA
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    miRTarBase miRNAs that target ARL4C:
    hsa-mir-103a-3p (MIRT027059), hsa-mir-26a-5p (MIRT006712), hsa-mir-192-5p (MIRT026645), hsa-mir-26b-5p (MIRT006715), hsa-mir-27a-3p (MIRT028730), hsa-mir-215-5p (MIRT024270)

    Block miRNA regulation of human, mouse, rat ARL4C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARL4C (see all 101):
    hsa-miR-579 hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-219-5p hsa-miR-3653 hsa-miR-30d hsa-miR-4315
    SwitchGear 3'UTR luciferase reporter plasmidARL4C 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARL4C

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    GenScript: all cDNA clones in your preferred vector: ARL4C (NM_005737)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL4C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARL4C_HUMAN, P56559: Cell projection, filopodium. Cell membrane. Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus4
    cytosol3
    endosome1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus TAS10462049
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--
    GO:0030175filopodium IEA--

    ARL4C for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARL4C
    Interactions:

        Search GeneGlobe Interaction Network for ARL4C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for ARL4C (P565592, 3 ENSP000003750574) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2867972 I2D: score=2 STRING: ENSP00000357292
    PIGTENSP000002790364STRING: ENSP00000279036
    POLR3EENSP000002998534STRING: ENSP00000299853
    STX16ENSP000003601834STRING: ENSP00000360183
    GBF1ENSP000003590004STRING: ENSP00000359000
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS10462049
    GO:0006886intracellular protein transport ----
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport ----
    GO:0032456endocytic recycling IDA19409876

    ARL4C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARL4C

    1 HMDB Compound for ARL4C    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARL4C gene (2 alternative transcripts): 
    NM_001282431.1  NM_005737.3  

    Unigene Cluster for ARL4C:

    ADP-ribosylation factor-like 4C
    Hs.111554  [show with all ESTs]
    Unigene Representative Sequence: AJ579850
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000390645(uc002vvn.3) ENST00000339728(uc002vvm.4)
    miRNA
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    Block miRNA regulation of human, mouse, rat ARL4C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARL4C (see all 101):
    hsa-miR-579 hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-219-5p hsa-miR-3653 hsa-miR-30d hsa-miR-4315
    SwitchGear 3'UTR luciferase reporter plasmidARL4C 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ARL4C
      QuantiFast Probe-based Assays in human, mouse, rat ARL4C

    Additional mRNA sequence: AJ579850.1 

    5 DOTS entries:

    DT.449758  DT.97847337  DT.97861457  DT.91745110  DT.100661299 

    Selected AceView cDNA sequences (see all 333):

    AA349786 F09688 BF434134 BM717241 BM876208 CB140646 CR623190 AA582631 
    AW079738 CA441253 AF493892 AI491793 W73356 BE463417 AI299654 AI424298 
    BQ008563 BU737368 CD358707 BF062935 BE675520 BU074136 AI423698 BM876467 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARL4C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAGGTCAT
    ARL4C Expression
    About this image


    ARL4C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
     
     Neural Ectoderm (Nervous System)
             Neural ectoderm cells
     
     Blood (Hematopoietic System)
             Plasmacytoid Dendritic cells Peripheral Blood
     
     Neural Tube (Nervous System)
             Floor plate-like cells
    ARL4C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARL4C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.111554

    UniProtKB/Swiss-Prot: ARL4C_HUMAN, P56559
    Tissue specificity: Expressed in several tumor cell lines (at protein level). Expressed in lung, brain, leukocytes
    and placenta

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARL4C gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arl4c1 , 5 ADP-ribosylation factor-like 4C1, 5 95.49(n)1
    100(a)1
      1 (44.85 cM)5
    3209821  NM_177305.41  NP_796279.21 
     886731255 
    chicken
    (Gallus gallus)
    Aves ARL4C1 ADP-ribosylation factor-like 4C 93.4(n)
    97.92(a)
      424026  XM_001237034.3  XP_001237035.2 
    lizard
    (Anolis carolinensis)
    Reptilia ARL4C6
    ADP-ribosylation factor-like 4C
    98(a)
    1 ↔ 1
    1(119149092-119149670)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.177652 Transcribed sequence with moderate similarity to protein more 82.26(n)    141993947 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc01g112 Danio rerio cDNA clone MGC77633 IMAGE6996875, complete more 78.63(n)    BC062829.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG22196
    --
    36(a)
    1 → many
    4(198064-200015)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARF36
    Glucose-repressible ADP-ribosylation factor, GTPas...
    39(a)
    1 → many
    XV(502795-503346) YOR094W


    ENSEMBL Gene Tree for ARL4C (if available)
    TreeFam Gene Tree for ARL4C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARL4C gene
    ARL4D2  ARL142  ARL4A2  ARL112  
    Selected SIMAP similar genes for ARL4C using alignment to 1 protein entry:     ARL4C_HUMAN(see all similar genes):
    ARL7    ARL4A    ARL4D    ARF5    ARL14    ARF6
    ARF1    ARF4    TRIM23    ARF3    ARL11    ARL3
    ARL10    ARL2    SAR1A    SAR1B    ARL5A    ARL1

    ARL4C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARL4C (see all 137)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1158968281,2
    C,F--235401221(+) GGACTC/TAGCCC 1 -- ds50011Minor allele frequency- T:0.05NA 120
    rs1811369681,2
    --235401229(+) CCCAGA/GTACTG 1 -- ds50010--------
    rs31153591,2
    C,F,A,H--235401375(-) TCCTCA/GGCACT 1 -- ds500128Minor allele frequency- N:0.00EA NA NS WA CSA 2965
    rs1848581931,2
    C--235401424(+) AATGAC/TGCAGT 1 -- ds50010--------
    rs1436081401,2
    C--235401514(+) CCACCA/GTTCAC 1 -- ds50010--------
    rs1142091671,2
    C,F--235401562(+) TGATAT/CACCGA 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs762755521,2
    C,F--235401563(+) GATATA/GCCGAC 1 -- ds50011Minor allele frequency- G:0.05WA 118
    rs1901459231,2
    --235401564(+) ATATAA/CCGACT 1 -- ds50010--------
    rs1818575511,2
    --235401641(+) CAATGC/TCAAAA 1 -- ds50010--------
    rs113864011,2
    C--235401642(+) AAAAAA/-CAAAC 1 -- ds50011Minor allele frequency- -:0.00CSA 2

    HapMap Linkage Disequilibrium report for ARL4C (235401685 - 235405697 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ARL4C: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARL4C
    DNA2.0 Custom Variant and Variant Library Synthesis for ARL4C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604787    OMIM disorders: --

    5 diseases for ARL4C:    
    About MalaCards
    cholera    pancreatic cancer    ataxia    pancreatitis
    cerebritis


    ARL4C for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARL4C

    Export disorders for ARL4C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARL4C gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with ARL4C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ADP-ribosylation factor like 7 (ARL7) interacts with alpha-tubulin and modulates intracellular vesicular transport. (PubMed id 19409876)1, 2, 9 Wei S.M.... Cai J.T. (Biochem. Biophys. Res. Commun. 2009)
    2. Genome-wide association study of pancreatic cancer in Japanese population. (PubMed id 20686608)1, 4 Low S.K....Sakamoto H. (PLoS ONE 2010)
    3. The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. (PubMed id 17398095)1, 2 Hofmann I.... Munro S. (Curr. Biol. 2007)
    4. ADP-ribosylation factor (ARF)-like 7 (ARL7) is induced by cholesterol loading and participates in apolipoprotein AI-dependent cholesterol export. (PubMed id 15147902)1, 2 Engel T.... Seedorf U. (FEBS Lett. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal. (PubMed id 10462049)1, 2 Jacobs S....Joost H.-G. (FEBS Lett. 1999)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. (PubMed id 21187453)1 Hong C....Tontonoz P. (J. Lipid Res. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10123 HGNC: 698 AceView: ARL7 Ensembl:ENSG00000188042 euGenes: HUgn10123
    ECgene: ARL4C H-InvDB: ARL4C

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARL4C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ARL4C gene:
    Search GeneIP for patents involving ARL4C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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