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ARL4A Gene

protein-coding   GIFtS: 51
GCID: GC07P012726

ADP-Ribosylation Factor-Like 4A

(Previous name: ADP-ribosylation factor-like 4)
(Previous symbol: ARL4)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADP-Ribosylation Factor-Like 4A1 2
ARL41 2 3 5
ADP-Ribosylation Factor-Like 41 2
ADP-Ribosylation Factor-Like Protein 4A2

External Ids:    HGNC: 6951   Entrez Gene: 101242   Ensembl: ENSG000001226447   OMIM: 6047865   UniProtKB: P406173   

Export aliases for ARL4A gene to outside databases

Previous GC identifers: GC07P012471 GC07P012499 GC07P012693


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARL4A Gene:
ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A
is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guaninine
nucleotide exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple
transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for ARL4A Gene:
ARL4A (ADP-ribosylation factor-like 4A) is a protein-coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is ARL4D.

UniProtKB/Swiss-Prot: ARL4A_HUMAN, P40617
Function: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and
the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins
(GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit.
Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form

Gene Wiki entry for ARL4A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARL4A gene promoter:
         Oct-B1   oct-B2   oct-B3   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ARL4A promoter sequence
   Search Chromatin IP Primers for ARL4A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARL4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p21.3   Ensembl cytogenetic band:  7p21.3   HGNC cytogenetic band: 7p21.3

ARL4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL4A gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P012726:  view genomic region     (about GC identifiers)

Start:
12,726,452 bp from pter      End:
12,730,559 bp from pter
Size:
4,108 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 12,777,588-12,781,695     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ARL4A_HUMAN, P40617 (See protein sequence)
Recommended Name: ADP-ribosylation factor-like protein 4A  
Size: 200 amino acids; 22615 Da
Subunit: Interacts with CYTH2. Interacts with KPNA2; the interaction is direct. Does not interacts with ARL4A
Secondary accessions: A4D119 P80418 Q49AF5

Explore the universe of human proteins at neXtProt for ARL4A: NX_P40617

Explore proteomics data for ARL4A at MOPED

Post-translational modifications: 

  • Myristoylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARL4A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001032241.1  NP_001182325.1  NP_005729.1  NP_997625.1  

    ENSEMBL proteins: 
     ENSP00000379897   ENSP00000349250   ENSP00000379899   ENSP00000397651   ENSP00000385236  
     ENSP00000379898  

    ARL4A Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for ARL4A (8 products) 

     
    antibodies-online peptides for ARL4A

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARL: ADP-ribosylation factors-like
    ARF: ADP-ribosylation factors

    5 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF

    Graphical View of Domain Structure for InterPro Entry P40617

    ProtoNet protein and cluster: P40617

    1 Blocks protein domain: IPB006688 ADP-ribosylation factor

    UniProtKB/Swiss-Prot: ARL4A_HUMAN, P40617
    Similarity: Belongs to the small GTPase superfamily. Arf family


    Find genes that share domains with ARL4A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARL4A_HUMAN, P40617
    Function: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and
    the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins
    (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit.
    Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0005515protein binding IPI10980193
    GO:0005525GTP binding IDA10980193
         
    Find genes that share ontologies with ARL4A           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARL4A:
     Decreased melanin production  Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Arl4a):
     adipose tissue  endocrine/exocrine gland  homeostasis/metabolism  reproductive system 

    Find genes that share phenotypes with ARL4A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Arl4atm1Asch for ARL4A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARL4A
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    miRNA
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    miRTarBase miRNAs that target ARL4A:
    hsa-mir-26b-5p (MIRT030339)

    Block miRNA regulation of human, mouse, rat ARL4A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARL4A (see all 82):
    hsa-miR-579 hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-200a hsa-miR-30d hsa-miR-3653 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidARL4A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARL4A

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL4A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARL4A_HUMAN, P40617: Cell membrane. Cytoplasm. Nucleus, nucleolus. Note=Localization in the nucleolus is
    dependent by nucleotide binding
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytosol3
    extracellular1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA10980193
    GO:0005730nucleolus IDA10980193
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IDA17398095

    Find genes that share ontologies with ARL4A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARL4A
    Interactions:

        Search GeneGlobe Interaction Network for ARL4A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for ARL4A (P406173 ENSP000003492504) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KPNA2P522923, ENSP000003324554I2D: score=2 STRING: ENSP00000332455
    NKD1Q969G93I2D: score=1 
    PIGTENSP000002790364STRING: ENSP00000279036
    POLR3EENSP000002998534STRING: ENSP00000299853
    STX16ENSP000003601834STRING: ENSP00000360183
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0006886intracellular protein transport ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport ----

    Find genes that share ontologies with ARL4A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for ARL4A



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARL4A gene (4 alternative transcripts): 
    NM_001037164.2  NM_001195396.1  NM_005738.4  NM_212460.3  

    Unigene Cluster for ARL4A:

    ADP-ribosylation factor-like 4A
    Hs.245540  [show with all ESTs]
    Unigene Representative Sequence: NM_005738
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396662(uc003ssq.3) ENST00000356797 ENST00000396664 ENST00000439721
    ENST00000404894 ENST00000396663(uc003ssp.3 uc021zzq.1 uc003sss.3)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ARL4A (see all 82):
    hsa-miR-579 hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-200a hsa-miR-30d hsa-miR-3653 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidARL4A 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ARL4A
      QuantiFast Probe-based Assays in human, mouse, rat ARL4A

    Additional mRNA sequence: 

    AF493890.1 AK313233.1 BC001111.2 BC003027.1 U73960.1 

    6 DOTS entries:

    DT.113752  DT.121080158  DT.100792805  DT.100028464  DT.100028466  DT.121255341 

    Selected AceView cDNA sequences (see all 206):

    AA744367 AV715591 AA055537 BU784677 BM550177 CR598643 AF493890 AW780345 
    D79888 CA431200 AA083371 BU844544 BP376080 BM979023 NM_005738 BE272886 
    AI313467 AI224585 CA311435 BG575521 NM_212460 AI151110 AL539827 CA309708 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARL4A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATATGATCAT
    ARL4A Expression
    About this image


    ARL4A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte Precursor Cells Forebrain White Matter
             Midbrain dopaminergic-like neurons
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
    ARL4A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARL4A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.245540
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARL4A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arl4a1 , 5 ADP-ribosylation factor-like 4A1, 5 92.5(n)1
    99.5(a)1
      12 (18.06 cM)5
    118611  NM_001039515.11  NP_001034604.11 
     400054475 
    chicken
    (Gallus gallus)
    Aves ARL4A1 ADP-ribosylation factor-like 4A 80.83(n)
    96.5(a)
      420589  XM_418690.3  XP_418690.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARL4A6
    ADP-ribosylation factor-like 4A
    95(a)
    1 ↔ 1
    6(25852470-25857454)
    African clawed frog
    (Xenopus laevis)
    Amphibia AY009369.12   -- 79.28(n)    AY009369.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc778002 hypothetical protein MGC77800 76.66(n)   393834  BC050164.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG22191 CG2219 60.16(n)
    59.53(a)
      43771  NM_143648.3  NP_651905.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARF36
    Glucose-repressible ADP-ribosylation factor, GTPas...
    40(a)
    1 → many
    XV(502795-503346) YOR094W


    ENSEMBL Gene Tree for ARL4A (if available)
    TreeFam Gene Tree for ARL4A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARL4A gene
    ARL4D2  ARL142  ARL112  ARL4C2  
    Selected SIMAP similar genes for ARL4A using alignment to 2 protein entries:     ARL4A_HUMAN (see all proteins) (see all similar genes):
    ARL4C    ARL7    ARL4D    ARF4    ARF5    ARL14
    ARF3    ARL8A    ARF1    ARF6    ARL8B    ARL1
    ARL11    ARL5A    ARL5B    TRIM23    ARL2    SAR1A

    Find genes that share paralogs with ARL4A           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for ARL4A
    PGOHUM00000251260 PGOHUM00000251271 PGOHUM00000237557 PGOHUM00000250217 PGOHUM00000263316


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARL4A (see all 160)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1839776491,2
    C--12724463(+) AACCTC/GCGCCT 2 -- us2k10--------
    rs1434620191,2
    --12724464(+) ACCTCC/TGCCTC 2 -- us2k10--------
    rs20336031,2
    C,F,A--12724470(-) GCCCGG/AGAGGC 2 -- us2k16Minor allele frequency- A:0.17NA CSA WA EA 364
    rs1467368031,2
    --12724582(+) CCCACG/TTTGGC 2 -- us2k10--------
    rs1883106861,2
    --12724651(+) AGTCAC/TAAAAG 2 -- us2k10--------
    rs1392962801,2
    --12724680(+) ATAGCG/TGTCTT 2 -- us2k10--------
    rs1150178301,2
    C,F--12724693(+) GAAAAA/GCTAGG 2 -- us2k11Minor allele frequency- G:0.03WA 118
    rs20336021,2
    C,F,A,H--12724698(-) AATATC/GCTAGT 2 -- us2k123Minor allele frequency- G:0.15NA EA NS CSA WA 2596
    rs1440692721,2
    --12724699(+) CTAGGA/GTATTT 2 -- us2k10--------
    rs736785221,2
    C,F--12724742(+) AAAAAA/GGCACA 2 -- us2k12Minor allele frequency- G:0.22WA 120

    HapMap Linkage Disequilibrium report for ARL4A (12726452 - 12730559 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ARL4A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830907CNV Loss17160897
    nsv830908CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARL4A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604786    OMIM disorders: --


    Find genes that share disorders with ARL4A           About GenesLikeMe

    Genetic Association Database (GAD): ARL4A

    Export disorders for ARL4A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARL4A gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with ARL4A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. (PubMed id 17398095)1, 2 Hofmann I.... Munro S. (Curr. Biol. 2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    4. ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli. (PubMed id 10980193)1, 2 Lin C.Y.... Lee F.J. (J. Biol. Chem. 2000)
    5. ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal. (PubMed id 10462049)1, 2 Jacobs S....Joost H.-G. (FEBS Lett. 1999)
    6. ARL4A acts with GCC185 to modulate Golgi complex organization. (PubMed id 22159419)1 Lin Y.C....Lee F.J. (J. Cell. Sci. 2011)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family. (PubMed id 21930703)1 Patel M....CA'tAc J.F. (J. Biol. Chem. 2011)
    9. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PubMed id 21658281)4 Aouizerat B.E....Tseng Z.H. (BMC Cardiovasc Disord 2011)
    10. Increased expression of the glioma-associated antigen ARF4L after loss of the tumor suppressor PTEN. Laboratory investigation. (PubMed id 18240926)1 Chi J.H....Parsa A.T. (J. Neurosurg. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10124 HGNC: 695 AceView: ARL4A Ensembl:ENSG00000122644 euGenes: HUgn10124
    ECgene: ARL4A H-InvDB: ARL4A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ARL4A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARL4A gene:
    Search GeneIP for patents involving ARL4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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