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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARL4A Gene

protein-coding   GIFtS: 51
GCID: GC07P012726

ADP-ribosylation factor-like 4A

(Previous name: ADP-ribosylation factor-like 4 )
(Previous symbol: ARL4)
 Explore 2 diseases affiliated with
ARL4A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ARL4A    

Aliases
for ARL4A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ADP-Ribosylation Factor-Like 4A1 2
ARL41 2 3 5
ADP-Ribosylation Factor-Like 41 2
ADP-Ribosylation Factor-Like Protein 4A2

External Ids:    HGNC: 6951   Entrez Gene: 101242   Ensembl: ENSG000001226447   OMIM: 6047865   UniProtKB: P406173   

Export aliases for ARL4A gene to outside databases

Previous GC identifers: GC07P012471 GC07P012499 GC07P012693


Summaries
for ARL4A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ARL4A:
ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is
similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guaninine nucleotide
exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple transcript variants
encoding the same protein have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ARL4A_HUMAN, P40617
Function: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the
rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP).
GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits
CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form

Gene Wiki entry for ARL4A


Genomic Views
for ARL4A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARL4A gene promoter:
         Oct-B1   oct-B2   oct-B3   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ARL4A promoter sequence
   Search SABiosciences Chromatin IP Primers for ARL4A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p21.3   Ensembl cytogenetic band:  7p21.3   HGNC cytogenetic band: 7p21.3

ARL4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL4A gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P012726:  view genomic region     (about GC identifiers)

Start:
 12,726,481 bp from pter      End:
 12,730,559 bp from pter
Size:
 4,079 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 12,777,617-12,781,695     

Proteins
for ARL4A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ARL4A_HUMAN, P40617 (See protein sequence)
Recommended Name: ADP-ribosylation factor-like protein 4A  
Size: 200 amino acids; 22615 Da
Subunit: Interacts with CYTH2. Interacts with KPNA2; the interaction is direct. Does not interacts with ARL4A
Subcellular location: Cell membrane. Cytoplasm. Nucleus, nucleolus. Note=Localization in the nucleolus is dependent by
nucleotide binding
Secondary accessions: A4D119 P80418 Q49AF5

Explore the universe of human proteins at neXtProt for ARL4A: NX_P40617

Post-translational modifications:

  • Myristoylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P40617

    • ARL4A Protein expression data from MOPED and PaxDb:    About this image 
    ARL4A Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001032241.1  NP_001182325.1  NP_005729.1  NP_997625.1  

    ENSEMBL proteins: 
     ENSP00000379897   ENSP00000349250   ENSP00000379899   ENSP00000397651   ENSP00000385236  
     ENSP00000379898  

    Human Recombinant Protein Products for ARL4A: 
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    Novus Biologicals ARL4A Proteins
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    Uscn Proteins for ARL4A

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10980193
    GO:0005730nucleolus IDA10980193
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IDA17398095

    ARL4A for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ARL4A

    Protein Domains /
    Families
    for ARL4A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ARL4A for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase

    Graphical View of Domain Structure for InterPro Entry P40617

    ProtoNet protein and cluster: P40617

    1 Blocks protein family: IPB006688 ADP-ribosylation factor

    UniProtKB/Swiss-Prot: ARL4A_HUMAN, P40617
    Similarity: Belongs to the small GTPase superfamily. Arf family


    Function
    for ARL4A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARL4A_HUMAN, P40617
    Function: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the
    rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP).
    GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits
    CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17398095
    GO:0005525GTP binding IDA10980193
         
    ARL4A for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARL4A:
     Decreased melanin production  Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Arl4a):
     adipose tissue  endocrine/exocrine gland  homeostasis/metabolism  reproductive system 

    ARL4A for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Arl4atm1Asch for ARL4A
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ARL4A 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARL4A
    8/82 QIAGEN miScript miRNA Assays for microRNAs that regulate ARL4A (see all 82):
    hsa-miR-579 hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-200a hsa-miR-30d hsa-miR-3653 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmid: ARL4A 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARL4A (see all 7)
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    OriGene siRNA: ARL4A
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of ARL4A 
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL4A


    Pathways & Interactions
    for ARL4A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARL4A

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for ARL4A (P406173 ENSP000003492504) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KPNA2P522923, ENSP000003324554I2D: score=2 STRING: ENSP00000332455
    NKD1Q969G93I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0050873brown fat cell differentiation IEA--

    ARL4A for ontologies           About GeneDecksing



    Drugs & Compounds
    for ARL4A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARL4A
    Search CenterWatch for drugs/clinical trials and news about ARL4A 

    Transcripts
    for ARL4A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ARL4A gene (4 alternative transcripts): 
    NM_001037164.2  NM_001195396.1  NM_005738.4  NM_212460.3  

    Unigene Cluster for ARL4A:

    ADP-ribosylation factor-like 4A
    Hs.245540  [show with all ESTs]
    Unigene Representative Sequence: NM_005738
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396662(uc003ssq.3) ENST00000356797 ENST00000396664 ENST00000439721
    ENST00000404894 ENST00000396663(uc003ssp.3 uc021zzq.1 uc003sss.3)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARL4A
    8/82 QIAGEN miScript miRNA Assays for microRNAs that regulate ARL4A (see all 82):
    hsa-miR-579 hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-200a hsa-miR-30d hsa-miR-3653 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmid: ARL4A 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARL4A (see all 7)
    OriGene shRNA RFP: ARL4A
    OriGene siRNA: ARL4A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARL4A
    Sirion Biotech Custom design and validation of potent shRNA sequences against ARL4A 
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): ARL4A (NM_001037164)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARL4A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARL4A

    Additional cDNA sequence: 

    AF493890.1 AK313233.1 BC001111.2 BC003027.1 U73960.1 

    6 DOTS entries:

    DT.113752  DT.121080158  DT.100792805  DT.100028464  DT.100028466  DT.121255341 

    24/206 AceView cDNA sequences (see all 206):

    D79888 CA431200 AV715591 AI151110 BM802164 BM550177 AA083371 AL539827 
    AI313467 CD367268 BM979023 BU844544 BP376080 AA744367 BG575521 AF493890 
    CR614654 AW780345 CA309708 AW083580 AA055537 BE272886 BM832972 NM_005738 

    GeneLoc Exon Structure


    Expression
    for ARL4A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARL4A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATATGATCAT
    ARL4A Expression
    About this image

    ARL4A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyInterstitial StromaKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)
    Posterior foregut-like cells (A scalable, suspensi...)

    See ARL4A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARL4A

    SOURCE GeneReport for Unigene cluster: Hs.245540
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    In Situ
    Assay Products:     
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    Orthologs
    for ARL4A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ARL4A gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ARL4A1 ADP-ribosylation factor-like 4A 80.83(n)
    96.5(a)    		   420589  XM_418690.2  XP_418690.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ARL4A6
    		 --
    		 95(a)
    		 1 ↔ 1
    		 6(25854417-25855019)
    African clawed frog
    (Xenopus laevis)    		 Amphibia AY009369.12   -- 79.28(n)    AY009369.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc778002 hypothetical protein MGC77800 76.66(n)   393834  BC050164.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG22191 CG2219 58.03(n)
    56.82(a)    		   43771  NM_143648.2  NP_651905.1 


    ENSEMBL Gene Tree for ARL4A (if available)
    TreeFam Gene Tree for ARL4A (if available) 

    Paralogs
    for ARL4A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARL4A gene
    ARL112  ARF42  ARF52  ARF12  ARF32  ARL4D2  ARL142  ARF62  
    ARL92  ARL17B2  ARL4C2  TRIM232  ARL102  
    18/28 SIMAP similar genes for ARL4A using alignment to 2 protein entries:     ARL4A_HUMAN (see all proteins) (see all similar genes):
    ARL4C    ARL7    ARL4D    ARF4    ARF5    ARF3
    ARL14    ARL8A    ARF1    ARF6    ARL8B    ARL1
    ARL11    ARL5A    ARL5B    TRIM23    ARL2    SAR1A

    ARL4A for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for ARL4A
    PGOHUM00000251260 PGOHUM00000251271 PGOHUM00000237557 PGOHUM00000250217 PGOHUM00000263316


    Genomic Variants
    for ARL4A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/142 NCBI SNPs in ARL4A are shown (see all 142)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1839776491,2
    		--12724463(+) AACCTC/GCGCCT 2 -- us2k10--------
    rs1434620191,2
    		--12724464(+) ACCTCC/TGCCTC 2 -- us2k10--------
    rs20336031,2
    		C,F,A--12724470(-) GCCCGG/AGAGGC 2 -- us2k16Minor allele frequency- A:0.17NA CSA WA EA 364
    rs1467368031,2
    		--12724582(+) CCCACG/TTTGGC 2 -- us2k10--------
    rs1883106861,2
    		--12724651(+) AGTCAC/TAAAAG 2 -- us2k10--------
    rs1392962801,2
    		--12724680(+) ATAGCG/TGTCTT 2 -- us2k10--------
    rs1150178301,2
    		C,F--12724693(+) GAAAAA/GCTAGG 2 -- us2k11Minor allele frequency- G:0.03WA 118
    rs20336021,2
    		C,F,A,H--12724698(-) AATATC/GCTAGT 2 -- us2k123Minor allele frequency- G:0.15NA EA NS CSA WA 2596
    rs1440692721,2
    		--12724699(+) CTAGGA/GTATTT 2 -- us2k10--------
    rs736785221,2
    		C--12724742(+) AAAAAA/GGCACA 2 -- us2k12Minor allele frequency- G:0.22WA 120

    HapMap Linkage Disequilibrium report for ARL4A (12726481 - 12730559 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ARL4A
         1 CNV: 94382

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    Disorders / Diseases
    for ARL4A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ARL4A for disorders           About GeneDecksing

    OMIM gene information: 604786    OMIM disorders: --

    2 diseases for ARL4A:    About MalaCards
    cholera    malaria


    Export disorders for ARL4A gene to outside databases

    Publications
    for ARL4A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARL4A gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with ARL4A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. (PubMed id 17398095)1, 2 Hofmann I....Munro S. (2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    4. ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli. (PubMed id 10980193)1, 2 Lin C.Y....Lee F.J. (2000)
    5. ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal. (PubMed id 10462049)1, 2 Jacobs S....Joost H.-G. (1999)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. The Arf family GTPase Arl4A complexes with ELMO prote ins to promote actin cytoskeleton remodeling and reveals a versatile Ras-bindin g domain in the ELMO proteins family. (PubMed id 21930703)1 Patel M....CA'tAc J.F. (2011)
    8. ARL4A acts with GCC185 to modulate Golgi complex organ ization. (PubMed id 22159419)1 Lin Y.C....Lee F.J. (2011)
    9. Increased expression of the glioma-associated antigen ARF4L after loss of the tumor suppressor PTEN. Laboratory investigation. (PubMed id 18240926)1 Chi J.H....Parsa A.T. (2008)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    External Searches for ARL4A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing ARL4A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10124 HGNC: 695 AceView: ARL4A Ensembl:ENSG00000122644 euGenes: HUgn10124
    ECgene: ARL4A H-InvDB: ARL4A

    Other Databases showing ARL4A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ARL4A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARL4A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ARL4A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ARL4A gene:
    Search GeneIP for patents involving ARL4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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