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Aliases for ARL4A Gene

Aliases for ARL4A Gene

  • ADP Ribosylation Factor Like GTPase 4A 2 3 5
  • ADP-Ribosylation Factor-Like 4A 2 3
  • ADP-Ribosylation Factor-Like 4 2 3
  • ARL4 3 4
  • ADP-Ribosylation Factor Like GTPase 4A 3

External Ids for ARL4A Gene

Previous HGNC Symbols for ARL4A Gene

  • ARL4

Previous GeneCards Identifiers for ARL4A Gene

  • GC07P012471
  • GC07P012499
  • GC07P012693
  • GC07P012726

Summaries for ARL4A Gene

Entrez Gene Summary for ARL4A Gene

  • ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guaninine nucleotide exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARL4A Gene

ARL4A (ADP Ribosylation Factor Like GTPase 4A) is a Protein Coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is ARL11.

UniProtKB/Swiss-Prot for ARL4A Gene

  • Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.

Gene Wiki entry for ARL4A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL4A Gene

Genomics for ARL4A Gene

Regulatory Elements for ARL4A Gene

Promoters for ARL4A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARL4A on UCSC Golden Path with GeneCards custom track

Genomic Location for ARL4A Gene

Chromosome:
7
Start:
12,686,827 bp from pter
End:
12,690,934 bp from pter
Size:
4,108 bases
Orientation:
Plus strand

Genomic View for ARL4A Gene

Genes around ARL4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL4A Gene

Proteins for ARL4A Gene

  • Protein details for ARL4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40617-ARL4A_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 4A
    Protein Accession:
    P40617
    Secondary Accessions:
    • A4D119
    • P80418
    • Q49AF5

    Protein attributes for ARL4A Gene

    Size:
    200 amino acids
    Molecular mass:
    22615 Da
    Quaternary structure:
    • Interacts with CYTH2. Interacts with KPNA2; the interaction is direct. Does not interacts with ARL4A.

neXtProt entry for ARL4A Gene

Proteomics data for ARL4A Gene at MOPED

Post-translational modifications for ARL4A Gene

Antibody Products

No data available for DME Specific Peptides for ARL4A Gene

Domains & Families for ARL4A Gene

Gene Families for ARL4A Gene

Protein Domains for ARL4A Gene

Suggested Antigen Peptide Sequences for ARL4A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P40617

UniProtKB/Swiss-Prot:

ARL4A_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL4A: view

Function for ARL4A Gene

Molecular function for ARL4A Gene

UniProtKB/Swiss-Prot Function:
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.

Gene Ontology (GO) - Molecular Function for ARL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10980193
genes like me logo Genes that share ontologies with ARL4A: view
genes like me logo Genes that share phenotypes with ARL4A: view

Animal Models for ARL4A Gene

MGI Knock Outs for ARL4A:

Animal Model Products

CRISPR Products

miRNA for ARL4A Gene

miRTarBase miRNAs that target ARL4A

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARL4A Gene

Localization for ARL4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL4A Gene

Cell membrane. Cytoplasm. Nucleus, nucleolus. Note=Localization in the nucleolus is dependent by nucleotide binding.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARL4A Gene COMPARTMENTS Subcellular localization image for ARL4A gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 3
extracellular 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ARL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane IDA 17398095
genes like me logo Genes that share ontologies with ARL4A: view

Pathways & Interactions for ARL4A Gene

SuperPathways for ARL4A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with ARL4A: view

No data available for Pathways by source and SIGNOR curated interactions for ARL4A Gene

Drugs & Compounds for ARL4A Gene

No Compound Related Data Available

Transcripts for ARL4A Gene

Unigene Clusters for ARL4A Gene

ADP-ribosylation factor-like 4A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL4A Gene

No ASD Table

Relevant External Links for ARL4A Gene

GeneLoc Exon Structure for
ARL4A
ECgene alternative splicing isoforms for
ARL4A

Expression for ARL4A Gene

mRNA expression in normal human tissues for ARL4A Gene

mRNA differential expression in normal tissues according to GTEx for ARL4A Gene

This gene is overexpressed in Testis (x5.6).

Protein differential expression in normal tissues from HIPED for ARL4A Gene

This gene is overexpressed in Ovary (46.9) and Spleen (22.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARL4A Gene



SOURCE GeneReport for Unigene cluster for ARL4A Gene Hs.245540

genes like me logo Genes that share expression patterns with ARL4A: view

Protein tissue co-expression partners for ARL4A Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ARL4A Gene

Orthologs for ARL4A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARL4A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARL4A 35
  • 94.5 (n)
  • 99.5 (a)
ARL4A 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100684100 35
  • 94.67 (n)
  • 99.5 (a)
ARL4A 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arl4a 35
  • 92.5 (n)
  • 99.5 (a)
Arl4a 16
Arl4a 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARL4A 35
  • 99.5 (n)
  • 100 (a)
ARL4A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arl4a 35
  • 93.33 (n)
  • 99.5 (a)
oppossum
(Monodelphis domestica)
Mammalia ARL4A 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARL4A 35
  • 80.83 (n)
  • 96.5 (a)
ARL4A 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARL4A 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arl4a 35
  • 79.33 (n)
  • 89 (a)
Str.10753 35
zebrafish
(Danio rerio)
Actinopterygii arl4ab 35
  • 69.83 (n)
  • 80.5 (a)
zgc77800 35
arl4ab 36
  • 80 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6635 35
fruit fly
(Drosophila melanogaster)
Insecta CG2219 35
  • 60.16 (n)
  • 59.53 (a)
CG2219 36
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARF3 36
  • 40 (a)
OneToMany
Species with no ortholog for ARL4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARL4A Gene

ENSEMBL:
Gene Tree for ARL4A (if available)
TreeFam:
Gene Tree for ARL4A (if available)

Paralogs for ARL4A Gene

Paralogs for ARL4A Gene

genes like me logo Genes that share paralogs with ARL4A: view

Variants for ARL4A Gene

Sequence variations from dbSNP and Humsavar for ARL4A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_024367 -
rs14730 -- 12,689,072(+) CAAAT(C/T)TTTTG utr-variant-3-prime
rs1058268 -- 12,689,644(+) ACTTT(C/G)ACTTG utr-variant-3-prime
rs2033602 -- 12,685,073(-) AATAT(C/G)CTAGT upstream-variant-2KB
rs2033603 -- 12,684,845(-) GCCCG(A/G)GAGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ARL4A Gene

Variant ID Type Subtype PubMed ID
nsv830907 CNV Loss 17160897
nsv830908 CNV Gain 17160897

Variation tolerance for ARL4A Gene

Residual Variation Intolerance Score: 52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARL4A Gene

HapMap Linkage Disequilibrium report
ARL4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL4A Gene

Disorders for ARL4A Gene

Relevant External Links for ARL4A

Genetic Association Database (GAD)
ARL4A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARL4A

No disorders were found for ARL4A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL4A Gene

Publications for ARL4A Gene

  1. ARL4A acts with GCC185 to modulate Golgi complex organization. (PMID: 22159419) Lin Y.C. … Lee F.J. (J. Cell. Sci. 2011) 2 3 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family. (PMID: 21930703) Patel M. … CA'tAc J.F. (J. Biol. Chem. 2011) 3
  4. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (PMID: 19490893) Luo J. … Elledge S.J. (Cell 2009) 3
  5. Increased expression of the glioma-associated antigen ARF4L after loss of the tumor suppressor PTEN. Laboratory investigation. (PMID: 18240926) Chi J.H. … Parsa A.T. (J. Neurosurg. 2008) 3

Products for ARL4A Gene

Sources for ARL4A Gene

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