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Aliases for ARL4A Gene

Aliases for ARL4A Gene

  • ADP Ribosylation Factor Like GTPase 4A 2 3 5
  • ADP-Ribosylation Factor-Like 4A 2 3
  • ADP-Ribosylation Factor-Like 4 2 3
  • ARL4 3 4
  • ADP-Ribosylation Factor-Like Protein 4A 3

External Ids for ARL4A Gene

Previous HGNC Symbols for ARL4A Gene

  • ARL4

Previous GeneCards Identifiers for ARL4A Gene

  • GC07P012471
  • GC07P012499
  • GC07P012693
  • GC07P012726

Summaries for ARL4A Gene

Entrez Gene Summary for ARL4A Gene

  • ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guaninine nucleotide exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARL4A Gene

ARL4A (ADP Ribosylation Factor Like GTPase 4A) is a Protein Coding gene. Among its related pathways are Mesodermal Commitment Pathway. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is ARL4C.

UniProtKB/Swiss-Prot for ARL4A Gene

  • Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.

Gene Wiki entry for ARL4A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL4A Gene

Genomics for ARL4A Gene

Regulatory Elements for ARL4A Gene

Enhancers for ARL4A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G012721 1.4 Ensembl ENCODE dbSUPER 4.9 +36.0 35979 1.6 HDAC1 HDGF ATF1 TBL1XR1 ARNT NFRKB TCF12 ZNF766 GATA2 ZBTB2 ARL4A GC07M012701 LOC105375161
GH07G012717 1.7 FANTOM5 Ensembl ENCODE dbSUPER 3.6 +32.7 32740 3.5 PKNOX1 NFRKB EGR1 FOS CREM SMARCC1 CEBPB ZNF592 CREB3 ZNF589 ARL4A GC07M012701 ENSG00000199470 GC07M012700
GH07G012951 1.2 Ensembl ENCODE 5.1 +264.9 264940 1.0 PKNOX1 ATF1 ARNT ZNF133 SIN3A TCF12 GATA2 FOS JUNB NCOA1 TMEM106B ARL4A GC07M012931 LOC105375158
GH07G012709 2 FANTOM5 Ensembl ENCODE dbSUPER 2.9 +26.9 26877 7.9 FOXA2 ARNT SIN3A FEZF1 ZNF2 ZNF766 FOS KLF13 DEK REST VWDE ARL4A GC07M012701 ENSG00000199470 GC07M012700
GH07G012669 1.1 Ensembl ENCODE 5.2 -16.1 -16083 1.8 FOXA2 FEZF1 THRB RARA ZSCAN5C CREM CEBPB TSHZ1 ZNF843 PRDM6 ARL4A LOC105375157 ENSG00000229233
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARL4A on UCSC Golden Path with GeneCards custom track

Promoters for ARL4A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000208526 1673 4601 CREB3L1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC MEF2D GLIS1

Genomic Location for ARL4A Gene

Chromosome:
7
Start:
12,686,827 bp from pter
End:
12,690,934 bp from pter
Size:
4,108 bases
Orientation:
Plus strand

Genomic View for ARL4A Gene

Genes around ARL4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL4A Gene

Proteins for ARL4A Gene

  • Protein details for ARL4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40617-ARL4A_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 4A
    Protein Accession:
    P40617
    Secondary Accessions:
    • A4D119
    • P80418
    • Q49AF5

    Protein attributes for ARL4A Gene

    Size:
    200 amino acids
    Molecular mass:
    22615 Da
    Quaternary structure:
    • Interacts with CYTH2. Interacts with KPNA2; the interaction is direct. Does not interacts with ARL4A.

neXtProt entry for ARL4A Gene

Post-translational modifications for ARL4A Gene

Antibody Products

  • Abcam antibodies for ARL4A
  • Santa Cruz Biotechnology (SCBT) Antibodies for ARL4A

No data available for DME Specific Peptides for ARL4A Gene

Domains & Families for ARL4A Gene

Gene Families for ARL4A Gene

Suggested Antigen Peptide Sequences for ARL4A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P40617

UniProtKB/Swiss-Prot:

ARL4A_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL4A: view

Function for ARL4A Gene

Molecular function for ARL4A Gene

UniProtKB/Swiss-Prot Function:
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.

Gene Ontology (GO) - Molecular Function for ARL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10980193
GO:0005525 GTP binding IDA 10980193
genes like me logo Genes that share ontologies with ARL4A: view
genes like me logo Genes that share phenotypes with ARL4A: view

Animal Models for ARL4A Gene

MGI Knock Outs for ARL4A:

Animal Model Products

CRISPR Products

miRNA for ARL4A Gene

miRTarBase miRNAs that target ARL4A

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ARL4A

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARL4A Gene

Localization for ARL4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL4A Gene

Cell membrane. Cytoplasm. Nucleus, nucleolus. Note=Localization in the nucleolus is dependent by nucleotide binding.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL4A gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ARL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 10980193
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IEA,IDA 10980193
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ARL4A: view

Pathways & Interactions for ARL4A Gene

SuperPathways for ARL4A Gene

SuperPathway Contained pathways
1 Mesodermal Commitment Pathway
genes like me logo Genes that share pathways with ARL4A: view

Pathways by source for ARL4A Gene

1 BioSystems pathway for ARL4A Gene

Gene Ontology (GO) - Biological Process for ARL4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0050873 brown fat cell differentiation IEA --
genes like me logo Genes that share ontologies with ARL4A: view

No data available for SIGNOR curated interactions for ARL4A Gene

Transcripts for ARL4A Gene

Unigene Clusters for ARL4A Gene

ADP-ribosylation factor-like 4A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ARL4A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL4A Gene

No ASD Table

Relevant External Links for ARL4A Gene

GeneLoc Exon Structure for
ARL4A
ECgene alternative splicing isoforms for
ARL4A

Expression for ARL4A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARL4A Gene

mRNA differential expression in normal tissues according to GTEx for ARL4A Gene

This gene is overexpressed in Testis (x5.6).

Protein differential expression in normal tissues from HIPED for ARL4A Gene

This gene is overexpressed in Ovary (46.9) and Spleen (22.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARL4A Gene



Protein tissue co-expression partners for ARL4A Gene

NURSA nuclear receptor signaling pathways regulating expression of ARL4A Gene:

ARL4A

SOURCE GeneReport for Unigene cluster for ARL4A Gene:

Hs.245540

Evidence on tissue expression from TISSUES for ARL4A Gene

  • Nervous system(4.5)
  • Heart(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with ARL4A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL4A Gene

Orthologs for ARL4A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARL4A Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ARL4A 35
  • 100 (a)
OneToOne
LOC100684100 34
  • 94.67 (n)
chimpanzee
(Pan troglodytes)
Mammalia ARL4A 34 35
  • 99.5 (n)
cow
(Bos Taurus)
Mammalia ARL4A 34 35
  • 94.5 (n)
rat
(Rattus norvegicus)
Mammalia Arl4a 34
  • 93.33 (n)
mouse
(Mus musculus)
Mammalia Arl4a 34 16 35
  • 92.5 (n)
oppossum
(Monodelphis domestica)
Mammalia ARL4A 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARL4A 34 35
  • 80.83 (n)
lizard
(Anolis carolinensis)
Reptilia ARL4A 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arl4a 34
  • 79.33 (n)
Str.10753 34
zebrafish
(Danio rerio)
Actinopterygii arl4ab 34 35
  • 69.83 (n)
zgc77800 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6635 34
fruit fly
(Drosophila melanogaster)
Insecta CG2219 34 35
  • 60.16 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARF3 35
  • 40 (a)
OneToMany
Species where no ortholog for ARL4A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARL4A Gene

ENSEMBL:
Gene Tree for ARL4A (if available)
TreeFam:
Gene Tree for ARL4A (if available)

Paralogs for ARL4A Gene

Paralogs for ARL4A Gene

Pseudogenes.org Pseudogenes for ARL4A Gene

genes like me logo Genes that share paralogs with ARL4A: view

Variants for ARL4A Gene

Sequence variations from dbSNP and Humsavar for ARL4A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000324874 -- 12,690,015(+) GGAAG(A/C)AATGG utr-variant-3-prime
rs1001298906 -- 12,686,843(+) CGGGC(A/G)GCGCG upstream-variant-2KB, utr-variant-5-prime
rs1001548547 -- 12,685,775(+) CATTG(C/G)AGCAA upstream-variant-2KB
rs1002062919 -- 12,690,732(+) CTGTG(G/T)ATCAA utr-variant-3-prime
rs1002498737 -- 12,690,444(+) GAAAT(A/G)TGGAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ARL4A Gene

Variant ID Type Subtype PubMed ID
nsv830907 CNV loss 17160897
nsv830908 CNV gain 17160897
nsv970447 CNV duplication 23825009

Variation tolerance for ARL4A Gene

Residual Variation Intolerance Score: 52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARL4A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARL4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL4A Gene

Disorders for ARL4A Gene

Relevant External Links for ARL4A

Genetic Association Database (GAD)
ARL4A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARL4A

No disorders were found for ARL4A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL4A Gene

Publications for ARL4A Gene

  1. ARL4A acts with GCC185 to modulate Golgi complex organization. (PMID: 22159419) Lin Y.C. … Lee F.J. (J. Cell. Sci. 2011) 2 3 64
  2. The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. (PMID: 17398095) Hofmann I. … Munro S. (Curr. Biol. 2007) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  5. ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli. (PMID: 10980193) Lin C.Y. … Lee F.J. (J. Biol. Chem. 2000) 3 4 64

Products for ARL4A Gene

Sources for ARL4A Gene

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