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Aliases for ARL3 Gene

Aliases for ARL3 Gene

  • ADP-Ribosylation Factor-Like 3 2 3
  • ARFL3 3 4 6
  • ADP-Ribosylation Factor-Like Protein 3 3
  • ARF-Like 3 3

External Ids for ARL3 Gene

Previous GeneCards Identifiers for ARL3 Gene

  • GC10M103329
  • GC10M103669
  • GC10M104567
  • GC10M104100
  • GC10M104098
  • GC10M104423
  • GC10M098068

Summaries for ARL3 Gene

Entrez Gene Summary for ARL3 Gene

  • ADP-ribosylation factor-like 3 is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL3 binds guanine nucleotides but lacks ADP-ribosylation factor activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARL3 Gene

ARL3 (ADP-Ribosylation Factor-Like 3) is a Protein Coding gene. Diseases associated with ARL3 include retinitis pigmentosa 2 and retinitis pigmentosa. GO annotations related to this gene include GTP binding and microtubule binding. An important paralog of this gene is ENSG00000272822.

UniProtKB/Swiss-Prot for ARL3 Gene

  • Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium. Does not act as an allosteric activator of the cholera toxin catalytic subunit.

Gene Wiki entry for ARL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL3 Gene

Genomics for ARL3 Gene

Regulatory Elements for ARL3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARL3 Gene

Start:
102,673,727 bp from pter
End:
102,714,433 bp from pter
Size:
40,707 bases
Orientation:
Minus strand

Genomic View for ARL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL3 Gene

Proteins for ARL3 Gene

  • Protein details for ARL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36405-ARL3_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 3
    Protein Accession:
    P36405
    Secondary Accessions:
    • B2R6C7
    • Q53X83
    • Q5JSM2

    Protein attributes for ARL3 Gene

    Size:
    182 amino acids
    Molecular mass:
    20456 Da
    Quaternary structure:
    • Interacts with RP2. The GTP-bound form interacts with PDE6D. Found in a complex with ARL3, RP2 and UNC119 (or UNC119B); RP2 induces hydrolysis of GTP ARL3 in the complex, leading to the release of UNC119 (or UNC119B). Interacts with SYS1. The GTP-bound form interacts with ARL2BP and PDE6D. Interacts with RP2; interaction is direct and stimulated with the activated GTP-bound form of ARL3. Microtubule-associated protein. Does not interact with TBCC. May interact with GOLGA4.

neXtProt entry for ARL3 Gene

Proteomics data for ARL3 Gene at MOPED

Post-translational modifications for ARL3 Gene

  • Ubiquitination at Lys35 and Lys54
  • Modification sites at PhosphoSitePlus

Other Protein References for ARL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARL3 Gene

Domains for ARL3 Gene

Gene Families for ARL3 Gene

HGNC:
  • ARF :ADP-ribosylation factors
  • ARL :ADP-ribosylation factors-like

Suggested Antigen Peptide Sequences for ARL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P36405

UniProtKB/Swiss-Prot:

ARL3_HUMAN :
  • P36405
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL3: view

Function for ARL3 Gene

Molecular function for ARL3 Gene

GENATLAS Biochemistry: ADP-ribosylation factor-like 3,21kDa,low molecular weight GTP binding protein without intrinsic or ARF stimulated GTPase activity,ubiquitously expressed in normal tissues,also in tumor cell lines
UniProtKB/Swiss-Prot Function: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium. Does not act as an allosteric activator of the cholera toxin catalytic subunit.

Gene Ontology (GO) - Molecular Function for ARL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0004871 signal transducer activity --
GO:0005515 protein binding IPI 11847227
GO:0005524 ATP binding --
GO:0005525 GTP binding IDA 18588884
genes like me logo Genes that share ontologies with ARL3: view
genes like me logo Genes that share phenotypes with ARL3: view

Animal Model Products

CRISPR Products

miRNA for ARL3 Gene

miRTarBase miRNAs that target ARL3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARL3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARL3 Gene

Localization for ARL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL3 Gene

Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cell projection, cilium. Note=Detected predominantly in the photoreceptor connecting cilium. Present on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARL3 Gene COMPARTMENTS Subcellular localization image for ARL3 gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 5
nucleus 5
plasma membrane 4
cytosol 3

Gene Ontology (GO) - Cellular Components for ARL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005622 intracellular --
GO:0005634 nucleus IDA 16525022
GO:0005737 cytoplasm --
GO:0005794 Golgi apparatus IDA 16525022
genes like me logo Genes that share ontologies with ARL3: view

Pathways for ARL3 Gene

SuperPathways for ARL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis IMP 16525022
GO:0001822 kidney development ISS --
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport --
GO:0006892 post-Golgi vesicle-mediated transport IMP 20106869
genes like me logo Genes that share ontologies with ARL3: view

No data available for Pathways by source for ARL3 Gene

Compounds for ARL3 Gene

(2) Drugbank Compounds for ARL3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2-(N-Morpholino)-Ethanesulfonic Acid
target
Guanosine-5'-Diphosphate
146-91-8 target

(1) Novoseek inferred chemical compound relationships for ARL3 Gene

Compound -log(P) Hits PubMed IDs
gtp 40.9 5
genes like me logo Genes that share compounds with ARL3: view

Transcripts for ARL3 Gene

mRNA/cDNA for ARL3 Gene

(320) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARL3 Gene

ADP-ribosylation factor-like 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARL3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1:
SP2: -

Relevant External Links for ARL3 Gene

GeneLoc Exon Structure for
ARL3
ECgene alternative splicing isoforms for
ARL3

Expression for ARL3 Gene

mRNA expression in normal human tissues for ARL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARL3 Gene

SOURCE GeneReport for Unigene cluster for ARL3 Gene Hs.182215

mRNA Expression by UniProt/SwissProt for ARL3 Gene

P36405-ARL3_HUMAN
Tissue specificity: Expressed in the retina. Strongly expressed in connecting cilium, the myoid region of the inner segments (IS) and in cone photoreceptors (at protein level).
genes like me logo Genes that share expressions with ARL3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ARL3 Gene

Orthologs for ARL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARL3 35
  • 99.82 (n)
  • 100 (a)
ARL3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARL3 35
  • 95.24 (n)
  • 98.35 (a)
ARL3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARL3 35
  • 96.15 (n)
  • 98.35 (a)
ARL3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arl3 35
  • 89.74 (n)
  • 98.35 (a)
Arl3 16
Arl3 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARL3 36
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARL3 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arl3 35
  • 90.29 (n)
  • 97.25 (a)
chicken
(Gallus gallus)
Aves ARL3 35
  • 83.7 (n)
  • 96.7 (a)
ARL3 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARL3 36
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.17388 35
tropical clawed frog
(Silurana tropicalis)
Amphibia arl3 35
  • 82.6 (n)
  • 97.8 (a)
Str.11398 35
zebrafish
(Danio rerio)
Actinopterygii arl3 35
  • 79.85 (n)
  • 94.51 (a)
arl3 36
  • 95 (a)
OneToOne
zgc73049 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004496 35
  • 64.77 (n)
  • 73.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta dnd 35
  • 64.41 (n)
  • 65.54 (a)
dnd 36
  • 65 (a)
OneToOne
CG6560 37
  • 57 (a)
worm
(Caenorhabditis elegans)
Secernentea arl-3 35
  • 60.81 (n)
  • 63.74 (a)
arl-3 36
  • 63 (a)
OneToOne
arl-3 37
  • 63 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5648 36
  • 73 (a)
OneToOne
Species with no ortholog for ARL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARL3 Gene

ENSEMBL:
Gene Tree for ARL3 (if available)
TreeFam:
Gene Tree for ARL3 (if available)

Paralogs for ARL3 Gene

Selected SIMAP similar genes for ARL3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARL3: view

Variants for ARL3 Gene

Sequence variations from dbSNP and Humsavar for ARL3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs8354 -- 102,676,884(-) TAGAC(A/G)AATGG utr-variant-3-prime
rs884550 -- 102,676,856(+) GAATT(C/T)GGCTC utr-variant-3-prime
rs1043450 -- 102,674,452(-) TGATA(C/T)GTGCT utr-variant-3-prime
rs1141895 - 102,705,393(-) CTCTT(A/C)TGAAG missense, reference
rs2251772 -- 102,711,161(-) GAGAA(A/G)GAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARL3 Gene

Variant ID Type Subtype PubMed ID
nsv895980 CNV Loss 21882294
nsv831969 CNV Loss 17160897
esv2668455 CNV Deletion 23128226

Relevant External Links for ARL3 Gene

HapMap Linkage Disequilibrium report
ARL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL3 Gene

Disorders for ARL3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for ARL3 Gene including...

Search for ARL3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ARL3 Gene

Relevant External Links for ARL3

Genetic Association Database (GAD)
ARL3
Human Genome Epidemiology (HuGE) Navigator
ARL3
genes like me logo Genes that share disorders with ARL3: view

No data available for UniProtKB/Swiss-Prot for ARL3 Gene

Publications for ARL3 Gene

  1. Assignment of the human ADP-ribosylation factor-like 3 (ARL3) gene to chromosome 10 band q23.3 by radiation hybrid mapping. (PMID: 10072593) Kim H.S. (Cytogenet. Cell Genet. 1998) 2 3 23
  2. ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins. (PMID: 11303027) Van Valkenburgh H. … Kahn R.A. (J. Biol. Chem. 2001) 3 4 23
  3. Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3. (PMID: 12417528) Grayson C. … Cheetham M.E. (Hum. Mol. Genet. 2002) 3 4 23
  4. ADP-ribosylation factor (ARF)-like 3, a new member of the ARF family of GTP-binding proteins cloned from human and rat tissues. (PMID: 8034651) Cavenagh M.A. … Kahn R.A. (J. Biol. Chem. 1994) 2 3 4
  5. Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C. (PMID: 11847227) Bartolini F. … Cowan N.J. (J. Biol. Chem. 2002) 3 4

Products for ARL3 Gene

Sources for ARL3 Gene

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