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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARL3 Gene

protein-coding   GIFtS: 59
GCID: GC10M104423

ADP-ribosylation factor-like 3

 Explore 6 diseases affiliated with
ARL3 via our new
 Human Malady Compendium 
Biological research products
for ARL3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
ADP-Ribosylation Factor-Like 31 2
ARFL31 2 3 5
ADP-Ribosylation Factor-Like Protein 32
ARF-Like 32

External Ids:    HGNC: 6941   Entrez Gene: 4032   Ensembl: ENSG000001381757   OMIM: 6046955   UniProtKB: P364053   

Export aliases for ARL3 gene to outside databases

Previous GC identifers: GC10M103329 GC10M103669 GC10M104567 GC10M104100 GC10M104098 GC10M098068


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARL3:
ADP-ribosylation factor-like 3 is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL3 binds
guanine nucleotides but lacks ADP-ribosylation factor activity. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ARL3_HUMAN, P36405
Function: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the
rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP).
Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like
RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting
proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the
cilium. Does not act as an allosteric activator of the cholera toxin catalytic subunit

Gene Wiki entry for ARL3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARL3 gene promoter:
         TBP   NF-1/L   NF-1   Cdc5   Egr-4   GATA-2   Egr-2   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.3   Ensembl cytogenetic band:  10q24.32   HGNC cytogenetic band: 10q23.3

ARL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL3 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M104423:  view genomic region     (about GC identifiers)

Start:
104,433,488 bp from pter      End:
104,474,190 bp from pter
Size:
40,703 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ARL3_HUMAN, P36405 (See protein sequence)
Recommended Name: ADP-ribosylation factor-like protein 3  
Size: 182 amino acids; 20456 Da
Subunit: Interacts with RP2. The GTP-bound form interacts with PDE6D. Found in a complex with ARL3, RP2 and UNC119 (or
UNC119B); RP2 induces hydrolysis of GTP ARL3 in the complex, leading to the release of UNC119 (or UNC119B). Interacts
with SYS1. The GTP-bound form interacts with ARL2BP and PDE6D. Interacts with RP2; interaction is direct and
stimulated with the activated GTP-bound form of ARL3. Microtubule-associated protein. Does not interact with TBCC. May
interact with GOLGA4
Subcellular location: Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton,
spindle. Nucleus. Cytoplasm, cytoskeleton, centrosome. Cytoplasm. Cell projection, cilium. Note=Detected predominantly
in the photoreceptor connecting cilium. Present on the mitotic spindle. Centrosome-associated throughout the cell
cycle. Not detected to interphase microtubules
Secondary accessions: B2R6C7 Q53X83 Q5JSM2

Explore the universe of human proteins at neXtProt for ARL3: NX_P36405

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P36405

  • ARL3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004302.1  
    ENSEMBL proteins: 
     ENSP00000260746  

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    ProSpec Recombinant Protein for ARL3
    Uscn Proteins for ARL3

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--


    ARL3 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ARL3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF
     IPR005225 Small_GTP-bd_dom

    Graphical View of Domain Structure for InterPro Entry P36405

    ProtoNet protein and cluster: P36405

    2 Blocks protein families:
    IPB001019 Alpha G-protein (transducin) signature
    IPB006688 ADP-ribosylation factor


    UniProtKB/Swiss-Prot: ARL3_HUMAN, P36405
    Similarity: Belongs to the small GTPase superfamily. Arf family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ARL3_HUMAN, P36405
    Function: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the
    rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP).
    Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like
    RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting
    proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the
    cilium. Does not act as an allosteric activator of the cholera toxin catalytic subunit

         Genatlas biochemistry entry for ARL3:
    ADP-ribosylation factor-like 3,21kDa,low molecular weight GTP binding protein without intrinsic or ARF stimulated
    GTPase activity,ubiquitously expressed in normal tissues,also in tumor cell lines

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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005515protein binding IPI--
    GO:0005525GTP binding IDA--
    GO:0008017microtubule binding IDA12417528
    GO:0019003GDP binding IDA18588884


    ARL3 for ontologies           About GeneDecksing


    Animal Models:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Arl3):
     endocrine/exocrine gland  growth/size  immune system  liver/biliary system  mortality/aging 
     nervous system  renal/urinary system  vision/eye 

    ARL3 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/72 Interacting proteins for ARL3 (P364052, 3 ENSP000002607464) via UniProtKB, MINT, STRING, and/or I2D (see all 72)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UNC119Q134322, 3, ENSP000003370404MINT-6602347 MINT-6602360 MINT-6602369 MINT-63696 MINT-6602233 I2D: score=5 STRING: ENSP00000337040
    TBCDQ9BTW92, 3, ENSP000003477194MINT-6602333 I2D: score=1 STRING: ENSP00000347719
    TP53P046372, 3MINT-63694 I2D: score=5 
    UBR1Q8IWV72, 3MINT-63697 I2D: score=5 
    LRIF1Q5T3J32, 3MINT-63698 I2D: score=4 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis IMP16525022
    GO:0001822kidney development ISS--
    GO:0006184GTP catabolic process ----
    GO:0007049cell cycle IEA--
    GO:0007264small GTPase mediated signal transduction IDA--


    ARL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ARL3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ARL3

    2 DrugBank Compounds for ARL3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-(N-Morpholino)-Ethanesulfonic Acid-- --target--10592235
    Guanosine-5'-Diphosphate-- 146-91-8target--10592235

    1 Novoseek chemical compound relationship for ARL3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 40.9 7 10518933 (5)

    Search CenterWatch for drugs/clinical trials and news about ARL3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARL3 gene: 
    NM_004311.3  

    Unigene Cluster for ARL3:

    ADP-ribosylation factor-like 3
    Hs.182215  [show with all ESTs]
    Unigene Representative Sequence: NM_004311
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000260746(uc001kwa.3)

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    hsa-miR-3678-3p hsa-miR-607 hsa-miR-642a hsa-miR-1224-3p hsa-miR-15a hsa-miR-1260b hsa-miR-138-2* hsa-miR-4275
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARL3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARL3

    Additional cDNA sequence: 

    AF038193.1 AF493889.1 AK312525.1 BC008032.1 BC009841.2 CR407637.1 U07151.1 

    6 DOTS entries:

    DT.447982  DT.40205222  DT.443911  DT.97844780  DT.95366499  DT.314537 

    24/320 AceView cDNA sequences (see all 320):

    BQ772128 F13309 NM_004311 BF446732 BM681990 AW590103 CA421454 AA365672 
    AW276634 BQ071369 AI375900 CF528781 AU151056 F10907 AL134231 BC008032 
    AA099603 AF493889 Z44075 BU737600 AI669044 BM977908 CN480805 BM699974 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ARL3    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:                                                
    SP2:                          -                     


    ECgene alternative splicing isoforms for ARL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AACTGGGTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ARL3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARL3

    SOURCE GeneReport for Unigene cluster: Hs.182215

    UniProtKB/Swiss-Prot: ARL3_HUMAN, P36405
    Tissue specificity: Expressed in the retina. Strongly expressed in connecting cilium, the myoid region of the inner
    segments (IS) and in cone photoreceptors (at protein level)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ARL3 gene from 6/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ARL31 ADP-ribosylation factor-like 3 83.7(n)
    96.7(a)
      423865  XM_421730.3  XP_421730.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARL36
    --
    75(a)
    1 ↔ 1
    3(40061205-40076889)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.173882 Xenopus laevis ADP-ribosylation factor-like protein more 82.19(n)    AF467986.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc730492 hypothetical protein MGC73049 74.77(n)   393666  BC059431.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG65603
    dnd1
    ARF small monomeric GTPase3
    dead end1
    57(a)3
    64.41(n)1
    65.54(a)1
      93F93
    425801  NM_142738.21  NP_650995.11 
    worm
    (Caenorhabditis elegans)
    Secernentea arl-31 , 3 ADP-ribosylation factors (Arf family)
    (contains more3
    Protein ARL-31
    63(a)3
    60.81(n)1
    63.74(a)1
      II(14602843-14603996)3
    1751211  NM_064636.11  NP_497037.11 


    ENSEMBL Gene Tree for ARL3 (if available)
    TreeFam Gene Tree for ARL3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARL3 gene
    ARL152  ARL22  ARL8A2  ARL8B2  
    18/28 SIMAP similar genes for ARL3 using alignment to 1 protein entry:     ARL3_HUMAN(see all similar genes):
    ARF5    ARL11    ARL1    ARL2    ARF1    ARL14
    ARF4    ARF6    ARL10    ARF3    ARL5A    ARL5B
    ARL6    ARL8B    ARL9    ARL8A    ARL4D    ARL15

    ARL3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/676 NCBI SNPs in ARL3 are shown (see all 676    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs107089381,2
    C,--98080748(+) ATCAG-/AAAAAA 1 -- int1 trp32Minor allele frequency- A:0.00NA CSA 4
    rs1427030991,2
    --104433000(+) ACCACA/GCCCGG 1 -- ds50010--------
    rs1469223161,2
    --104433066(+) TGAACG/TCCTGA 1 -- ds50010--------
    rs42887001,2
    C,F,H,--104433308(+) TATCTA/GAAGTG 1 -- ds500122Minor allele frequency- G:0.05NS EA NA WA CSA 1604
    rs1393729131,2
    --104433321(+) CGGCAC/TGTAGG 1 -- ds50010--------
    rs1494390031,2
    --104433466(+) AAAGAA/GCACAA 1 -- ds50010--------
    rs1857014891,2
    --104433693(+) CTGGTC/TCCCGA 1 -- ut310--------
    rs1893012711,2
    --104433699(+) CCCGAC/GAAGGA 1 -- ut310--------
    rs590448881,2
    C,--104433838(+) GCACAG/AAAATA 1 -- ut311Minor allele frequency- A:0.50WA 2
    rs1481517941,2
    --104433939(+) AGGACC/TATGTC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ARL3 (104433488 - 104474190 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ARL3: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ARL3 for disorders           About GeneDecksing

    OMIM gene information: 604695    OMIM disorders: --

    6 diseases for ARL3:    About MalaCards
    retinitis pigmentosa-2    retinitis pigmentosa    retinitis    cholera
    alzheimer's disease    neuronitis

    1 disease from the University of Copenhagen DISEASES database for ARL3:
    Retinitis pigmentosa
    Human Genome Epidemiology (HuGE) Navigator: ARL3 (1 document)

    Export disorders for ARL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARL3 gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with ARL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ADP-ribosylation factor (ARF)-like 3, a new member of the ARF family of GTP-binding proteins cloned from human and rat tissues. (PubMed id 8034651)1, 2, 3 Cavenagh M.A.... Kahn R.A. (1994)
    2. ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins. (PubMed id 11303027)1, 2, 9 Van Valkenburgh H.... Kahn R.A. (2001)
    3. Assignment of the human ADP-ribosylation factor-like 3 (ARL3) gene to chromosome 10 band q23.3 by radiation hybrid mapping. (PubMed id 10072593)1, 3, 9 Kim H.S. (1998)
    4. Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3. (PubMed id 12417528)1, 2, 9 Grayson C....Cheetham M.E. (2002)
    5. Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3- effector-GAP complex. (PubMed id 18588884)1, 2 Veltel S.... Wittinghofer A. (2008)
    6. Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3. (PubMed id 16472755)1, 2 Kuehnel K.... Wittinghofer A. (2006)
    7. Arl2 and Arl3 regulate different microtubule-dependent processes. (PubMed id 16525022)1, 2 Zhou C.... Kahn R.A. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C. (PubMed id 11847227)1, 2 Bartolini F....Cowan N.J. (2002)
    10. The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE delta, interacts with the Arf-like protein Arl3 in a GTP specific manner. (PubMed id 10518933)1, 9 Linari M.... Becker J. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 403 HGNC: 694 AceView: ARL3 Ensembl:ENSG00000138175 euGenes: HUgn403
    ECgene: ARL3 H-InvDB: ARL3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARL3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ARL3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARL3 gene:
    Search GeneIP for patents involving ARL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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