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ARL3 Gene

protein-coding   GIFtS: 63
GCID: GC10M104423

ADP-Ribosylation Factor-Like 3

  See ARL3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADP-Ribosylation Factor-Like 31 2
ARFL32 3 5
ADP-Ribosylation Factor-Like Protein 32
ARF-Like 32

External Ids:    HGNC: 6941   Entrez Gene: 4032   Ensembl: ENSG000001381757   OMIM: 6046955   UniProtKB: P364053   

Export aliases for ARL3 gene to outside databases

Previous GC identifers: GC10M103329 GC10M103669 GC10M104567 GC10M104100 GC10M104098 GC10M098068


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARL3 Gene:
ADP-ribosylation factor-like 3 is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL3
binds guanine nucleotides but lacks ADP-ribosylation factor activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for ARL3 Gene:
ARL3 (ADP-ribosylation factor-like 3) is a protein-coding gene. Diseases associated with ARL3 include retinitis pigmentosa 2. GO annotations related to this gene include microtubule binding and GTP binding. An important paralog of this gene is ARL2.

UniProtKB/Swiss-Prot: ARL3_HUMAN, P36405
Function: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and
the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins
(GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins
(GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for
targeting proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo
adapter into the cilium. Does not act as an allosteric activator of the cholera toxin catalytic subunit

Gene Wiki entry for ARL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARL3 gene promoter:
         TBP   NF-1/L   NF-1   Cdc5   Egr-4   GATA-2   Egr-2   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARL3 promoter sequence
   Search Chromatin IP Primers for ARL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.3   Ensembl cytogenetic band:  10q24.32   HGNC cytogenetic band: 10q23.3

ARL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL3 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M104423:  view genomic region     (about GC identifiers)

Start:
104,433,484 bp from pter      End:
104,474,190 bp from pter
Size:
40,707 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ARL3_HUMAN, P36405 (See protein sequence)
Recommended Name: ADP-ribosylation factor-like protein 3  
Size: 182 amino acids; 20456 Da
Subunit: Interacts with RP2. The GTP-bound form interacts with PDE6D. Found in a complex with ARL3, RP2 and UNC119
(or UNC119B); RP2 induces hydrolysis of GTP ARL3 in the complex, leading to the release of UNC119 (or UNC119B).
Interacts with SYS1. The GTP-bound form interacts with ARL2BP and PDE6D. Interacts with RP2; interaction is
direct and stimulated with the activated GTP-bound form of ARL3. Microtubule-associated protein. Does not
interact with TBCC. May interact with GOLGA4
Secondary accessions: B2R6C7 Q53X83 Q5JSM2

Explore the universe of human proteins at neXtProt for ARL3: NX_P36405

Explore proteomics data for ARL3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys35, Lys54
  • Modification sites at PhosphoSitePlus

  • See ARL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004302.1  
    ENSEMBL proteins: 
     ENSP00000260746  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARL: ADP-ribosylation factors-like
    ARF: ADP-ribosylation factors

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR027417 P-loop_NTPase
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF

    Graphical View of Domain Structure for InterPro Entry P36405

    ProtoNet protein and cluster: P36405

    2 Blocks protein domains:
    IPB001019 Alpha G-protein (transducin) signature
    IPB006688 ADP-ribosylation factor


    UniProtKB/Swiss-Prot: ARL3_HUMAN, P36405
    Similarity: Belongs to the small GTPase superfamily. Arf family


    Find genes that share domains with ARL3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARL3_HUMAN, P36405
    Function: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and
    the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins
    (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins
    (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for
    targeting proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo
    adapter into the cilium. Does not act as an allosteric activator of the cholera toxin catalytic subunit

         Genatlas biochemistry entry for ARL3:
    ADP-ribosylation factor-like 3,21kDa,low molecular weight GTP binding protein without intrinsic or ARF stimulated
    GTPase activity,ubiquitously expressed in normal tissues,also in tumor cell lines

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0004871signal transducer activity ----
    GO:0005515protein binding IPI11847227
    GO:0005524ATP binding ----
    GO:0005525GTP binding IDA18588884
         
    Find genes that share ontologies with ARL3           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Arl3):
     endocrine/exocrine gland  growth/size/body  immune system  liver/biliary system  mortality/aging 
     nervous system  renal/urinary system  vision/eye 

    Find genes that share phenotypes with ARL3           About GenesLikeMe

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARL3
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    miRNA
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    hsa-mir-16-5p (MIRT031723), hsa-mir-103a-3p (MIRT027108)

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    Selected qRT-PCR Assays for microRNAs that regulate ARL3 (see all 99):
    hsa-miR-3678-3p hsa-miR-607 hsa-miR-642a hsa-miR-1224-3p hsa-miR-15a hsa-miR-1260b hsa-miR-138-2* hsa-miR-4275
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARL3_HUMAN, P36405: Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm,
    cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm.
    Cell projection, cilium. Note=Detected predominantly in the photoreceptor connecting cilium. Present on the
    mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    golgi apparatus5
    nucleus5
    plasma membrane4
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005622intracellular ----
    GO:0005634nucleus IDA16525022
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus IDA16525022

    Find genes that share ontologies with ARL3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARL3
    Interactions:

        GeneGlobe Interaction Network for ARL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARL3 (P364051, 2, 3 ENSP000002607464) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UNC119Q134321, 2, 3, ENSP000003370404EBI-712710,EBI-711260 MINT-6602347 MINT-6602360 MINT-6602369 MINT-63696 MINT-6602233 I2D: score=5 STRING: ENSP00000337040
    TBCDQ9BTW92, 3, ENSP000003477194MINT-6602333 I2D: score=1 STRING: ENSP00000347719
    TP53P046372, 3MINT-63694 I2D: score=5 
    UBR1Q8IWV72, 3MINT-63697 I2D: score=5 
    LRIF1Q5T3J32, 3MINT-63698 I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis IMP16525022
    GO:0001822kidney development ISS--
    GO:0006184GTP catabolic process ----
    GO:0006886intracellular protein transport ----
    GO:0006892post-Golgi vesicle-mediated transport IMP--

    Find genes that share ontologies with ARL3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARL3

    2 DrugBank Compounds for ARL3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-(N-Morpholino)-Ethanesulfonic Acid-- --target--10592235
    Guanosine-5'-Diphosphate-- 146-91-8target--10592235

    1 Novoseek inferred chemical compound relationship for ARL3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 40.9 7 10518933 (5)



    Find genes that share compounds with ARL3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARL3 gene: 
    NM_004311.3  

    Unigene Cluster for ARL3:

    ADP-ribosylation factor-like 3
    Hs.182215  [show with all ESTs]
    Unigene Representative Sequence: NM_004311
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000260746(uc001kwa.3)
    miRNA
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    hsa-miR-3678-3p hsa-miR-607 hsa-miR-642a hsa-miR-1224-3p hsa-miR-15a hsa-miR-1260b hsa-miR-138-2* hsa-miR-4275
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    Additional mRNA sequence: 

    AF038193.1 AF493889.1 AK312525.1 BC008032.1 BC009841.2 CR407637.1 U07151.1 

    6 DOTS entries:

    DT.447982  DT.40205222  DT.443911  DT.97844780  DT.95366499  DT.314537 

    Selected AceView cDNA sequences (see all 320):

    AA046366 Z44075 BM699974 AF038193 CN480805 AA825177 BF446732 BM661686 
    BM313005 BF114876 AU151056 AA365672 AA127576 BU187912 F12876 AA099603 
    AA988568 BC008032 CF528781 CF530067 AA112245 BM835801 AI669044 AF493889 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ARL3    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:                                                
    SP2:                          -                     


    ECgene alternative splicing isoforms for ARL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTGGGTCT
    ARL3 Expression
    About this image


    ARL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    ARL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.182215

    UniProtKB/Swiss-Prot: ARL3_HUMAN, P36405
    Tissue specificity: Expressed in the retina. Strongly expressed in connecting cilium, the myoid region of the
    inner segments (IS) and in cone photoreceptors (at protein level)

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARL3 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arl31 , 5 ADP-ribosylation factor-like 31, 5 89.74(n)1
    98.35(a)1
      19 (38.94 cM)5
    563501  NM_019718.21  NP_062692.11 
     465311095 
    chicken
    (Gallus gallus)
    Aves ARL31 ADP-ribosylation factor-like 3 83.7(n)
    96.7(a)
      423865  XM_421730.4  XP_421730.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARL36
    ADP-ribosylation factor-like 3
    75(a)
    1 ↔ 1
    3(40061205-40102966)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.173882 Xenopus laevis ADP-ribosylation factor-like protein more 82.19(n)    AF467986.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc730492 hypothetical protein MGC73049 74.77(n)   393666  BC059431.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG65603
    dnd1
    ARF small monomeric GTPase3
    dead end1
    57(a)3
    64.41(n)1
    65.54(a)1
      93F93
    425801  NM_142738.31  NP_650995.11 
    worm
    (Caenorhabditis elegans)
    Secernentea arl-31 , 3 ADP-ribosylation factors (Arf family)
    (contains more3
    arl-31
    63(a)3
    60.81(n)1
    63.74(a)1
      II(14602843-14603996)3
    1751211  NM_064636.11  NP_497037.11 


    ENSEMBL Gene Tree for ARL3 (if available)
    TreeFam Gene Tree for ARL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARL3 gene
    ARL22  ARL5B2  ENSG000002730032  ARL5C2  ARF42  ENSG000002728222  ARF52  ARF12  
    ARL5A2  ARF32  ARF62  TRIM232  
    Selected SIMAP similar genes for ARL3 using alignment to 1 protein entry:     ARL3_HUMAN(see all similar genes):
    ARL2    ARF5    ARL11    ARL1    ARF1    ARL14
    ARF4    ARF6    ARL10    ARL5A    ARL5B    ARL6
    ARL8B    ARL9    ARL8A    ARF3    ARL4D    ARL15

    Find genes that share paralogs with ARL3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARL3 (see all 719)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1427030991,2
    --104433000(+) ACCACA/GCCCGG 1 -- ds50010--------
    rs1469223161,2
    C--104433066(+) TGAACG/TCCTGA 1 -- ds50010--------
    rs42887001,2
    C,F,H--104433308(+) TATCTA/GAAGTG 1 -- ds500122Minor allele frequency- G:0.05NS EA NA WA CSA 1604
    rs1393729131,2
    --104433321(+) CGGCAC/TGTAGG 1 -- ds50010--------
    rs1494390031,2
    C--104433466(+) AAAGAA/GCACAA 1 -- ds50010--------
    rs1857014891,2
    --104433693(+) CTGGTC/TCCCGA 1 -- ut310--------
    rs1893012711,2
    --104433699(+) CCCGAC/GAAGGA 1 -- ut310--------
    rs590448881,2
    C,F--104433838(+) GCACAG/AAAATA 1 -- ut311Minor allele frequency- A:0.50WA 2
    rs1481517941,2
    --104433939(+) AGGACC/TATGTC 1 -- ut310--------
    rs70884701,2
    C,F,A,H--104434194(+) CCCACA/GACTGG 1 -- ut3111Minor allele frequency- G:0.18NS EA NA WA CSA 656

    HapMap Linkage Disequilibrium report for ARL3 (104433484 - 104474190 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ARL3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2668455CNV Deletion23128226
    nsv895980CNV Loss21882294
    nsv831969CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for ARL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604695    OMIM disorders: --

    1 disease for ARL3:    
    About MalaCards
    retinitis pigmentosa 2

    1 disease from the University of Copenhagen DISEASES database for ARL3:
    Retinitis pigmentosa

    Find genes that share disorders with ARL3           About GenesLikeMe

    Genetic Association Database (GAD): ARL3
    Human Genome Epidemiology (HuGE) Navigator: ARL3 (1 document)

    Export disorders for ARL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARL3 gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with ARL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ADP-ribosylation factor (ARF)-like 3, a new member of the ARF family of GTP-binding proteins cloned from human and rat tissues. (PubMed id 8034651)1, 2, 3 Cavenagh M.A.... Kahn R.A. (J. Biol. Chem. 1994)
    2. ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins. (PubMed id 11303027)1, 2, 9 Van Valkenburgh H.... Kahn R.A. (J. Biol. Chem. 2001)
    3. Assignment of the human ADP-ribosylation factor-like 3 (ARL3) gene to chromosome 10 band q23.3 by radiation hybrid mapping. (PubMed id 10072593)1, 3, 9 Kim H.S. (Cytogenet. Cell Genet. 1998)
    4. Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3. (PubMed id 12417528)1, 2, 9 Grayson C.... Cheetham M.E. (Hum. Mol. Genet. 2002)
    5. Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3- effector-GAP complex. (PubMed id 18588884)1, 2 Veltel S.... Wittinghofer A. (FEBS Lett. 2008)
    6. Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3. (PubMed id 16472755)1, 2 Kuehnel K.... Wittinghofer A. (Structure 2006)
    7. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    8. Arl2 and Arl3 regulate different microtubule-dependent processes. (PubMed id 16525022)1, 2 Zhou C.... Kahn R.A. (Mol. Biol. Cell 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C. (PubMed id 11847227)1, 2 Bartolini F....Cowan N.J. (J. Biol. Chem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 403 HGNC: 694 AceView: ARL3 Ensembl:ENSG00000138175 euGenes: HUgn403
    ECgene: ARL3 H-InvDB: ARL3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARL3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ARL3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARL3 gene:
    Search GeneIP for patents involving ARL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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